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Journal of Perinatology: Official Journal of the California Perinatal Association

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https://www.readbyqxmd.com/read/30232377/analysis-of-peak-inflating-pressure-and-inflating-pressure-limit-during-neonatal-volume-guaranteed-ventilation
#1
Eniko Szakmar, Colin J Morley, Gusztav Belteki
OBJECTIVES: To report how peak inflating pressure (PIP), tidal volume (VT) and low-tidal volume alarms are affected by maximum allowed inflating pressure (Pmax ) during volume guarantee (VG) ventilation. STUDY DESIGN: Ventilation data were analysed with 1 Hz sampling rate from 25 neonates receiving synchronised intermittent positive pressure ventilation with VG for >12 h. RESULTS: The difference between Pmax and PIP (Pdiff ) ranged between 5 and 20 mbar (median = 11 mbar) despite a protocol to keep Pmax 5 mbar above the "working PIP"...
September 19, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30232376/correction-neonatal-resuscitation-and-adaptation-score-vs-apgar-newborn-assessment-and-predictive-ability
#2
Teresa J Witcher, Shadi Jurdi, Vidhya Kumar, Aditi Gupta, Russell R Moores, Joseph Khoury, Henry J Rozycki
Since the publication of the above article, the authors have noted that the name of the first Item in the NRAS scoring system in Figure 1 was omitted. It is Heart Rate (C1). The authors apologise for any inconvenience caused by this error. The html and online pdf versions have now been rectified and carry the corrected Figure.
September 19, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30214029/low-birthweight-in-second-children-after-nurse-home-visiting
#3
Margaret L Holland, Susan W Groth, Joyce A Smith, Ying Meng, Harriet Kitzman
OBJECTIVE: To examine low birthweight and preterm birth of second children born to home-visited first-time mothers. SUBJECTS: Women were previously recruited for a randomized controlled trial of the home visiting model disseminated as Nurse-Family Partnership. 512 of these women had second children within 18 years of the first child's birth, and were included in our sample. RESULTS: The intervention was associated with a lower likelihood of low birthweight for second children (odds ratio: 0...
September 13, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30209351/urinary-tract-infection-is-common-in-vlbw-infants
#4
Caitlin M Drumm, Javedan N Siddiqui, Sameer Desale, Jayashree Ramasethu
OBJECTIVE: Determine the significance of urinary tract infection (UTI) as a cause of late onset sepsis (LOS) in very low birth weight (VLBW) infants in the Neonatal Intensive Care Unit (NICU). STUDY DESIGN: Analysis of blood, cerebrospinal fluid and urine culture results in VLBW infants >72-h old, admitted to the Georgetown University Hospital NICU between 2005 and 2015. RESULT: Of 527 VLBW infants, 297 (56.4%) underwent 911 evaluations for LOS; only one-third included urine cultures...
September 12, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30206349/genetic-relatedness-of-gram-negative-bacteria-colonizing-gut-and-skin-of-neonates-and-mother-s-own-milk
#5
Lle Parm, Jelena Štšepetova, Imbi Eelmäe, Mirjam Merila, Mari-Liis Ilmoja, Tuuli Metsvaht, Irja Lutsar, Hiie Soeorg
OBJECTIVE: We described colonization of mother's own milk with Gram-negative bacteria and its relationship with neonatal colonization. STUDY DESIGN: Gram-negative bacteria isolated from weekly collected stool, skin and mother's own milk of hospitalized preterm (n = 49) and healthy term neonates (n = 20) were genotyped. Colonization-related factors were determined by logistic regression. RESULTS: Gram-negative bacteria were isolated from mother's own milk of 22...
September 11, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30206348/antenatal-steroids-and-thyroid-hormone-function-in-preterm-infants
#6
Dinushan C Kaluarachchi, Qianqian Zhao, Tarah T Colaizy
BACKGROUND: Antenatal steroids (ANS) are used widely for women at risk of preterm delivery. Evidence on the effects of ANS on thyroid hormone function in preterm infants is limited. OBJECTIVES: To determine effects of ANS on thyroid hormone function in preterm infants. METHODS: A retrospective cohort study of preterm infants born before 30 weeks of gestation. Infants were divided into no ANS, partial ANS, and complete ANS groups. Thyroid function tests at day of life 30 were compared...
September 11, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30206347/initial-hematocrit-values-after-birth-and-peri-intraventricular-hemorrhage-in-extremely-low-birth-weight-infants
#7
Stephanie Dekom, Avani Vachhani, Krishan Patel, Lorayne Barton, Rangasamy Ramanathan, Shahab Noori
OBJECTIVE: Ischemia followed by reperfusion plays a significant role in the pathogenesis of peri/intraventricular hemorrhage (P/IVH). Delayed cord clamping promotes placental transfusion to newborn and is associated with decreased P/IVH. We hypothesized that extremely low birth weight (ELBW) infants with higher initial hematocrit (Hct) after birth are less likely to develop P/IVH. STUDY DESIGN: Pre- and postnatal data on inborn ELBW infants over 7 years were reviewed...
September 11, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30206346/does-fluid-restriction-improve-outcomes-in-infants-with-hypoxic-ischemic-encephalopathy-a-pilot-randomized-controlled-trial
#8
Vasanthan Tanigasalam, Nishad Plakkal, B Vishnu Bhat, Palanivel Chinnakali
OBJECTIVE: To evaluate whether a strategy of restricted fluid intake in the first 4 days reduces mortality and morbidity among term neonates with moderate to severe hypoxic ischemic encephalopathy (HIE) treated with therapeutic hypothermia. STUDY DESIGN: Eighty neonates with HIE were randomized between January 2016 and February 2018 to receive normal fluid intake (n = 40) or restricted fluid intake (two-third of normal intake; n = 40) in the first 4 days of life...
September 11, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30206345/prevalence-and-safety-of-diazoxide-in-the-neonatal-intensive-care-unit
#9
Keyaria D Gray, Kathryn Dudash, Carla Escobar, Colman Freel, Tylah Harrison, Chandler McMillan, Mihai Puia-Dumitrescu, C Michael Cotten, Robert Benjamin, Reese H Clark, Daniel K Benjamin, Rachel G Greenberg
OBJECTIVE: Diazoxide is used to treat infants with persistent hypoglycemia, but the prevalence of its use and adverse effects are not well described. We report demographic and clinical characteristics of infants treated with diazoxide in neonatal intensive care units (NICUs). STUDY DESIGN: Retrospective cohort study of infants 24-41 weeks' gestation admitted to 392 NICUs from 1997-2016, comparing characteristics between hypoglycemic infants exposed/not exposed to diazoxide...
September 11, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30202046/in-utero-idiopathic-ductal-constriction-a-prenatal-manifestation-of-alagille-and-williams-syndrome-arteriopathy
#10
Shardha Srinivasan, Lisa W Howley, Bettina F Cuneo, Kathryn C Chatfield
OBJECTIVE: Williams and Alagille syndromes are genetic disorders associated with pathologic arterial narrowing. We hypothesized that fetal idiopathic ductus arteriosus (DA) constriction may represent a prenatal manifestation of the arteriopathy associated with these syndromes. METHODS: Multi-institutional case series review of the pre- and postnatal medical records, echocardiograms, and genetic test results of fetuses presenting with idiopathic DA constriction. RESULTS: We identified four cases of idiopathic fetal DA constriction at 21-36 weeks of gestation...
September 10, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30202045/suspected-or-known-neonatal-sepsis-and-neurodevelopmental-delay-by-5-years
#11
Katrina Savioli, Christopher Rouse, Apryl Susi, Gregory Gorman, Elizabeth Hisle-Gorman
OBJECTIVE: Evaluate impact of known and suspected neonatal sepsis in the term and preterm infant on neurodevelopmental delay by 5 years. STUDY DESIGN: Included infants were born in 2009-2010 and followed for 5 years. Diagnostic codes and at least 5 days of antibiotic use identified suspected sepsis. Laboratory results confirmed known sepsis. Diagnostic codes stratified developmental delay by sub-type. Logistic regression analysis determined odds of developmental delay for sepsis and suspected sepsis...
September 10, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30185932/efficacy-of-daily-supplementation-of-800-iu-vitamin-d-on-vitamin-d-status-at-6-months-of-age-in-term-healthy-indian-infants
#12
Mayank Priyadarshi, Mari Jeeva Sankar, Nandita Gupta, Ramesh Agarwal, Vinod Paul, Ashok Deorari
OBJECTIVES: Most authorities recommend daily supplementation of 400 IU vitamin D for all term healthy neonates throughout infancy, however this dose was shown to be inadequate in an earlier study from our institution. We planned to evaluate if supplementation of 800 IU/day in term Indian infants would reduce the prevalence of vitamin D insufficiency (VDI) at 6 months of age. METHODS: In a prospective study, we supplemented 800 IU/day of vitamin D in 70 term infants from birth till 6 months of age...
September 5, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30185931/thyroid-function-in-neonates-of-women-with-subclinical-hypothyroidism-or-hypothyroxinemia
#13
Michael W Varner, Lisa Mele, Brian M Casey, Alan M Peaceman, Yoram Sorokin, Uma M Reddy, Ronald J Wapner, John M Thorp, George R Saade, Alan T N Tita, Dwight J Rouse, Baha Sibai, Jay D Iams, Brian M Mercer, Jorge Tolosa, Steve N Caritis
OBJECTIVE: To assess whether treatment of pregnant women with subclinical hypothyroidism or hypothyroxinemia alters neonatal TSH results. STUDY DESIGN: A planned secondary analysis of data from two multi-center randomized, double-masked, placebo-controlled thyroxine replacement trials in pregnant women with either subclinical hypothyroidism or hypothyroxinemia. Infant heel-stick specimens were obtained before discharge. We compared TSH levels between neonates born to mothers allocated to treatment or placebo within each trial and between neonates in the placebo groups...
September 5, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30177861/early-neonatal-morbidities-and-neurological-functioning-of-preterm-infants-2-weeks-after-birth
#14
Maaike A Hempenius, Elise A Verhagen, Jozien C Tanis, Christa Einspieler, Arend F Bos
OBJECTIVE: To determine the association between potential neonatal risk factors and the quality of general movements (GMs) in preterm infants. STUDY DESIGN: Prospective cohort study in 67 preterm infants. From video recordings made on Days 8 and 15, we scored the GMs as normal/abnormal and detailed aspects using the general movement optimality score (GMOS). Risk factors included respiratory insufficiency requiring mechanical ventilation, patent ductus arteriosus (PDA), and abnormal blood glucose levels...
September 3, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30177860/outcomes-of-extremely-premature-infants-with-twin-twin-transfusion-syndrome-treated-by-laser-therapy
#15
Julie Sommer, Anne-Monique Nuyt, François Audibert, Véronique Dorval, Sandrine Wavrant, Gabriel Altit, Anie Lapointe
OBJECTIVE: To compare short-term and long-term outcomes of preterm infants born at <29 weeks of gestational age (GA) with twin-twin transfusion syndrome (TTTS) treated with laser therapy to preterm twin infants without TTTS. DESIGN: Retrospective case-control study comparing 33 preterm TTTS twins to 101 preterm diamniotic-dichorionic (di-di) twins born at our institution between 2006 and 2015. RESULTS: GA at birth were 26.4 ± 1.4 weeks (TTTS) and 26...
September 3, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30171214/high-sensitivity-troponin-t-in-preterm-infants-with-a-hemodynamically-significant-patent-ductus-arteriosus
#16
Priyanka Asrani, Ashraf M Aly, Amyn K Jiwani, Bruce R Niebuhr, Robert H Christenson, Sunil K Jain
OBJECTIVE: To investigate if a hemodynamically significant patent ductus arteriosus (hsPDA) leads to elevated high-sensitivity troponin T (hsTnT) and NTproBNP levels in serum. STUDY DESIGN: Infants <34 weeks and <1500 g were prospectively enrolled, except those with major congenital or chromosomal anomalies. An echocardiogram (ECHO) was performed and hsTnT and NTproBNP were measured within 5 days of life and repeated after treatment of hsPDA. Clinical, ECHO, and hsTnT data were analyzed using Student t-test, two proportion z-test, and regression analysis...
August 31, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30171213/factors-associated-with-retinopathy-of-prematurity-ophthalmology-workload
#17
Jack Jacob, Zinnia Matrix, Debra Skopec, Benjamin Ticho, Robert W Arnold
OBJECTIVE: This article reports on retinopathy of prematurity (ROP) workload in the NICU related to severity of disease, gestational age at discharge, and practice variation. STUDY DESIGN: Data analysis on 1771 patients ≤ 30 weeks of gestation at birth from a de-identified data set of 13 NICUs. RESULTS: There was a positive relationship between the severity of ROP and (1) the number of exams per patient, (2) the severity of ROP, and (3) postmenstrual age at discharge...
August 31, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30166622/preterm-neuroimaging-and-neurodevelopmental-outcome-a-focus-on-intraventricular-hemorrhage-post-hemorrhagic-hydrocephalus-and-associated-brain-injury
#18
REVIEW
Rebecca A Dorner, Vera Joanna Burton, Marilee C Allen, Shenandoah Robinson, Bruno P Soares
Intraventricular hemorrhage in the setting of prematurity remains the most common cause of acquired hydrocephalus. Neonates with progressive post-hemorrhagic hydrocephalus are at risk for adverse neurodevelopmental outcomes. The goal of this review is to describe the distinct and often overlapping types of brain injury in the preterm neonate, with a focus on neonatal hydrocephalus, and to connect injury on imaging to neurodevelopmental outcome risk. Head ultrasound and magnetic resonance imaging findings are described separately...
August 30, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30166621/length-of-stay-and-cost-of-birth-hospitalization-effects-of-subfertility-and-art
#19
Dmitry Dukhovny, Sunah S Hwang, Daksha Gopal, Howard Cabral, Stacey Missmer, Hafsatou Diop, Eugene Declercq, Judy E Stern
OBJECTIVE: The objective of this study is to measure delivery length of stay (LOS) and cost as proxies for infant morbidity in assisted reproductive technology (ART) and subfertile deliveries. STUDY DESIGN: Massachusetts singleton births, ≥  23 weeks gestational age (GA) between 2004 and 2010, were linked with ART data, vital records, and hospital discharges. LOS and costs (2010 US dollars) of infants born to fertile (no ART or indicators of infertility), subfertile (indicators of infertility but no ART), and ART-treated (linked to ART data) deliveries were compared...
August 30, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30166620/respiratory-morbidities-in-late-preterm-and-term-infants-with-myelomeningocele
#20
María V Fraga, Annie Giaccone, N Scott Adzick
OBJECTIVE: To describe the incidence of respiratory morbidities in late preterm and term newborns with myelomeningocele (MMC) born by c-section. STUDY DESIGN: Single center retrospective cohort study of infants born between 34 0/7 and 40 6/7 weeks gestation with the diagnosis of MMC. The primary outcome was the incidence of respiratory morbidities and the secondary outcome was caffeine treatment for apnea at discharge. RESULTS: A total of  293 infants with MMC born by cesarean section were included in this cohort: 106 born late preterm, 120 early term, and 67 at term...
August 30, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
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