Fedor Simko, Olga Pechanova, Vaclav Pelouch, Kristina Krajcirovicova, Martina Mullerova, Kristina Bednarova, Michaela Adamcova, Ludovit Paulis
OBJECTIVE: Melatonin was shown to reduce blood pressure, oxidative load and to increase nitric oxide bioavailability predisposing melatonin to have antiremodelling potential. DESIGN: The aim of this study was to show whether melatonin can reverse left ventricular remodelling in spontaneously hypertensive rats (SHR) and to compare this potential protective effect with captopril, spironolactone, or simvastatin. METHODS: Six groups of 3-month old rats (eight per group) were treated for 5 weeks: control untreated Wistar rats, control SHR, SHR plus melatonin (10 mg/kg per 24 h), SHR plus captopril (100 mg/kg per 24 h), SHR plus spironolactone (200 mg/kg per 24 h) and SHR plus simvastatin (10 mg/kg per 24 h)...
August 2009: Journal of Hypertension. Supplement: Official Journal of the International Society of Hypertension