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Journal of Environmental Pathology, Toxicology and Oncology

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https://www.readbyqxmd.com/read/29283339/kai1-cd82-metastasis-suppressor-gene-as-a-therapeutic-target-for-non-small-cell-lung-carcinoma
#1
Venugopal Vinod Prabhu, S Niranjali Devaraj
Lung cancer is the most frequent malignancy and the leading cause of cancer-related death worldwide; it is the second most common cancer, comprising 1.69 million deaths worldwide per year. Among these, 85% of lung cancers are non-small-cell lung carcinoma (NSCLC). Metastasis is common in NSCLC patients and are responsible for most deaths. Kang-Ai 1 (KAI1), a tumor metastasis suppressor gene also known as Cluster of Differentiation 82 (CD82), is a member of the membrane tetraspanin protein family, which are capable of inhibiting the metastatic process in NSCLC...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29283338/aqueous-extract-of-smokeless-tobacco-gutkha-deregulates-tumor-suppressor-and-dna-repair-response-in-a-murine-model-of-smokeless-tobacco-use
#2
Angom Ranjana Devi, Mahuya Sengupta, Yashmin Choudhury
The effect of smokeless tobacco (gutkha) was investigated by treating male and female Swiss Albino mice with an aqueous extract of smokeless tobacco (AEST). AEST was administered at a dose of 25 mg kg-1 body weight per day for different time periods (6, 12, 16, and 24 weeks), and control animals were provided only drinking water without AEST for the same period. Control and AEST-treated mice were observed for different oxidative stress parameters, nitric oxide (NO) release, and myeloperoxidase (MPO) release, and they were evaluated for alterations in tumor suppressor and DNA repair responses in the liver and spleen...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29283337/oncocytic-adreno-cortical-tumors-pathological-features-of-16-cases-and-review-of-the-literature
#3
Yesim Ertan, Asuman Argon, Murat Özdemir, Banu Pınar Sarer Yürekli, Zafer Dökümcü, Özer Makay
Oncocytic neoplasms of the adrenal gland are extremely rare tumors. These tumors differ from their nononcocytic counterparts in some respects. The aim of this study was to review and discuss the clinical, histological, and immunohistochemical features of as well as the prognosis for these rare tumors. In total, 16 cases diagnosed as adrenocortical oncocytic neoplasms between January 2011 and December 2016 were included in the study. The demographic data, gross characteristics, histological data, and immunohistochemical data (Chromogranin-A, Synaptophysin, α-Inhibin, Melan-A, Ki67, PHH3) were reevaluated...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29283336/photothermal-therapy-employing-gold-nanoparticle-loaded-macrophages-as-delivery-vehicles-comparing-the-efficiency-of-nanoshells-versus-nanorods
#4
Catherine Christie, Steen J Madsen, Qian Peng, Henry Hirschberg
Macrophages (Ma) loaded with gold based nanoparticles, which convert near infrared light to heat, have been studied as targeted transport vectors for photothermal therapy (PTT) of tumors. The purpose of the experiments reported here was to compare the efficacy of gold-silica nanoshells (AuNS) and gold nanorods (AuNR) in macrophage mediated PTT. PTT efficacy was evaluated in hybrid glioma spheroids consisting of human glioma cells and either AuNS or AuNR loaded Ma, designated MaNS and MaNR respectivly. Spheroids were irradiated for 10 min...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29283335/molecular-mechanisms-of-uva-induced-melanoma
#5
Xiao Pudroma, Gongsang Duoji, Mantas Grigalavicius, Duan Jie, Asta Juzeniene
Cutaneous melanoma is a deadly skin cancer, resulting from malignant transformation of melanocytes. Long-wave ultraviolet radiation (315-400 nm) is able to damage DNA, cause mutations, and induce melanoma. However, the exact mechanisms of UVA-induced cutaneous melanoma remain a matter of debate. In this review, we give a brief characterization of the most important elements in the photobiology of UVA in melanomagenesis.
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29283334/relationship-between-topoisomerase-ii-alpha-overexpression-and-prognosis-in-chinese-gastric-cancer-patients
#6
Fangchao Zheng, Jiuda Zhao, Feng Du, Junhui Zhao, Guoshuang Shen, Fei Ma, Xinfu Ma, Li Dong, Wei Ma, Cunfang Shen, Shuyan Wang, Jinhua Ma, Yang Luo, Ziyi Wang, Binghe Xu
The aim of this study was to investigate topoisomerase II alpha (TOP2α) overexpression and its association with clinicopathological features and prognosis in gastric cancer (GC) patients. All selected GC patients at Affiliated Hospital of Qinghai University and Cancer Hospital, Chinese Academy of Medical Sciences, between December 2009 and December 2011, had formalin-fixed and paraffin-embedded tumor tissues. The patients received a telephone follow-up or in-/outpatient review, and their clinicopathological features and prognoses were analyzed...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29283333/neurosteroids-and-ischemic-stroke-progesterone-a-promising-agent-in-reducing-the-brain-injury-in-ischemic-stroke
#7
REVIEW
Syed Suhail Andrabi, Suhel Parvez, Heena Tabassum
Progesterone (P4), a well-known neurosteroid, is produced by ovaries and placenta in females and by adrenal glands in both sexes. Progesterone is also synthesized by central nervous system (CNS) tissues to perform various vital neurological functions in the brain. Apart from performing crucial reproductive functions, it also plays a pivotal role in neurogenesis, regeneration, cognition, mood, inflammation, and myelination in the CNS. A substantial body of experimental evidence from animal models documents the neuroprotective role of P4 in various CNS injury models, including ischemic stroke...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29199597/hepatocellular-carcinoma-and-possible-chemical-and-biological-causes-a-review
#8
Pinar Erkekoglu, Didem Oral, Ming-Wei Chao, Belmar Kocer-Gumusel
The development of hepatocellular carcinoma (HCC) is a multistep process. In HCC, progressive and morphologically distinct preneoplastic lesions/alterations associated with chronic liver injury, inflammation, hepatocellular degeneration/regeneration, necrosis, and small-cell dysplasia can be observed. The incidence of HCC exhibits regional and ethnic differences. Several cytotoxic and DNA-damaging chemicals are suggested to be the underlying causes of HCC-for example, acrylamide, perfluorooctanoic acid (PFOA), polychlorinated biphenyls (PCBs), benzo(a)pyrene (BaP), perfluorinated chemicals (PFCs), vinyl chloride monomer (VCM), and dietary contaminants (aflatoxins, ochratoxins)...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29199596/insulin-combined-with-glucose-improves-spatial-learning-and-memory-in-aluminum-chloride-induced-dementia-in-rats
#9
Madhavan Nampoothiri, Grandhi Venkata Ramalingayya, Nampurath Gopalan Kutty, Nandakumar Krishnadas, Chamallamudi Mallikarjuna Rao
Therapeutic intervention using drugs against Alzheimer disease is curative clinically. At present, there are no reports on the curative role of insulin in chronic models of dementia. We evaluated the curative role of insulin and its combination with glucose in dementia. We also investigated the impact of treatments on blood glucose to correlate with cognitive deficit. Further, we analyzed the interaction of treatments with the cholinergic system and oxidative stress in memory centers (i.e., hippocampus and frontal cortex)...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29199595/epidermal-growth-factor-receptor-tyrosine-kinase-a-potential-target-in-treatment-of-non-small-cell-lung-carcinoma
#10
REVIEW
Venugopal Vinod Prabhu, Niranjali Devaraj
Lung cancer is responsible for 1.6 million deaths. Approximately 80%-85% of lung cancers are of the non-small-cell variety, which includes squamous cell carcinoma, adenocarcinoma, and large-cell carcinoma. Knowing the stage of cancer progression is a requisite for determining which management approach-surgery, chemotherapy, radiotherapy, and/or immunotherapy-is optimal. Targeted therapeutic approaches with antiangiogenic monoclonal antibodies or tyrosine kinase inhibitors are one option if tumors harbor oncogene mutations...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29199594/dna-double-strand-breaks-caused-by-different-microorganisms-a-special-focus-on-helicobacter-pylori
#11
Pinar Erkekoglu, Didem Oral, Belmar Kocer-Gumusel, Ming-Wei Chao
The association between inflammation and cancer has long been recognized. Several studies have found that different types of tumors develop at sites of chronic inflammation. It is stated that over 15%-20% of malignancies worldwide can be related to infections caused by viruses, bacteria, and schistosomes. Inflammatory conditions are characterized by overexpression of inducible nitric oxide synthase (iNOS) and overproduction of nitric oxide/reactive nitrogen species (ROSs/RNSs) in epithelial cells. Reactive oxygen species (ROSs) may also lead to cellular alterations and eventually to inflammation...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29199593/insulin-protects-against-brain-oxidative-stress-with-an-apparent-effect-on-episodic-memory-in-doxorubicin-induced-cognitive-dysfunction-in-wistar-rats
#12
Grandhi Venkata Ramalingayya, Vishwajeet Sonawane, Sri Pragnya Cheruku, Anoop Kishore, Pawan G Nayak, Nitesh Kumar, Rekha S Shenoy, Krishnadas Nandakumar
The present study was aimed at assessing the protective effect of insulin against doxorubicin (DOX)-induced cognitive dysfunction in Wistar rats. Cognitive function for episodic memory was assessed by a novel object recognition task (NORT) in male Wistar rats. Oxidative stress markers-SOD, catalase, glutathione, and lipid peroxidation-in the hippocampus and frontal cortex were assessed using colorimetric methods. Doxorubicin treatment (2.5 mg/kg, i.p., every 5 days for 50 days) reduced recognition and discriminative indices in NORT with increased oxidative stress in the brain...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29199592/nephrotoxicity-in-rats-exposed-to-paracetamol-the-protective-role-of-moralbosteroid-a-steroidal-glycoside
#13
Gaurav Gupta, Dinesh Kumar Chellappan, Irene Satiko Kikuchi, Terezinha de Jesus Andreoli Pinto, Kavita Pabreja, Mohit Agrawal, Yogendra Singh, Juhi Tiwari, Kamal Dua
Paracetamol (PCM) has an acceptable safety profile when used at prescribed doses. However, it is now understood that paracetamol can damage the kidneys when administered as an overdose. In addition, oxidative stress can play a major role in causing nephrotoxicity. This investigation studies the efficacy of moralbosteroid isolated from M. alba stem bark. Nephrotoxicity was induced with administration of paracetamol. Nephroprotection was studied using two doses of the extract. The experimental animals were divided into four groups (n = 6)...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29199591/copine-3-as-a-novel-potential-drug-target-for-non-small-cell-lung-carcinoma
#14
Kunnathur Murugesan Sakthivel, Venugopal Vinod Prabhu
Cancer originates from uncontrolled cell division in any part of the body. The universal burden of cancer continues to increase, and its treatment remains ever more challenging. Among several cancers, lung cancer is the second most common, causing 1.6 million deaths worldwide per year. Approximately 85% of lung cancers are non-small-cell lung carcinomas (NSCLCs), which are considerably more difficult to treat than other cancers. Although various imaging, biopsy, and histopathological analyses are widely used, there are no effective or reliable biomarkers for detecting early lung carcinoma, particularly NSCLC...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29199590/regulating-rna-binding-motif-5-gene-expression-a-novel-therapeutic-target-for-lung-cancer
#15
Venugopal Vinod Prabhu, Niranjali Devaraj
RNA-binding motif protein 5 (RBM5), also known as LUCA-15/H37, is a gene that maps to human chromosome 3p21.3, a critical region that is deleted in a large number of human cancers, of which the majority are lung cancers, and that is predicted to contain one or more tumor suppressor genes (TSGs). RBM5 is a tumor suppressor gene and is most frequently deleted at the earliest stage of lung cancer development. It represents a significant area of recent progress in cancer genomic, cytogenetic, and molecular biological research because of its role in the induction of cell cycle arrest and apoptosis and the regulation of inhibition of in lung cancer metastasis...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/28605333/prevention-of-polyphenols-against-carcinogenesis-induced-by-environmental-carcinogens
#16
REVIEW
Marco Clementino, Xianglin Shi, Zhuo Zhang
Cancer is one of the major causes of death in humans. Of all cancers, 19% are attributed to exposure to environmental chemical carcinogens. Dietary polyphenols from teas, vegetables, fruits, and many others exhibit multiple activities against cancers. Exposure to environmental carcinogens such as ultraviolet B (UVB), polycyclic aromatic hydrocarbons (PAHs), and heavy metals has been demonstrated to cause cancer in humans. In this article, we specifically select UVB, PAHs, and metals as representative of three types of environmental carcinogens: physical, organic, and inorganic, respectively...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/28605332/protective-effect-of-curcumin-against-carbofuran-induced-toxicity-in-wistar-rats
#17
Binitha P Purushothaman, Ramadasan Kuttan
Pesticide carbofuran (Furadan) is known to be an inhibitor of nerve impulses by its inhibition of acetylcholinesterase. Oral administration of carbofuran also produced tissue damage as evidenced by the increased the activities of creatine kinase (CK), lactate dehydrogenase (LDH), and gamma glutamyl transferase (γ-GT) in tissues and serum. Against carbofuran, curcumin restored the activities of acetylcholinesterase, LDH, CK and γ- GT in animals. Curcumin also restored the reduced mitochondrial enzymes in rat liver caused by carbofuran...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/28605331/classification-source-and-effect-of-environmental-pollutants-and-their-biodegradation
#18
REVIEW
Blessy Baby Mathew, Himani Singh, Vinai George Biju, N B Krishnamurthy
Any foreign chemical substance that is unusually present within an organism or is unexpectedly found in the environment at a higher concentration than the permissible limits can be termed a xenobiotic or a pollutant. Such substances include carcinogens, drugs, food additives, hydrocarbons, dioxins, polychlorinated biphenyls, pesticides or even some natural compounds. Pollutants are known for their higher persistence and pervasiveness, and along with their transformed products, they can remain in and interact with the environment for prolonged periods...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/28605330/effect-of-antihypertensive-drug-treatment-on-oxidative-stress-markers-in-heart-of-spontaneously-hypertensive-rat-models
#19
Nik Syamimi Nik Yusoff, Zulkarnain Mustapha, Sharifah Emilia Tuan Sharif, Chandran Govindasamy, Kuttulebbai Nainamohamed Salam Sirajudeen
Oxidative stress has been suggested to play a role in hypertension- and hypertension-induced organ damage. The effect of antihypertensive drug treatments on oxidative stress markers has not been well assessed. Therefore, in this study we investigated the effect of enalapril on oxidative stress markers in hearts of hypertensive rat models such as spontaneously hypertensive rats (SHR) and SHRs administered N-nitro-L-arginine methyl ester (SHR+L-NAME rats). Male rats were divided into four groups: SHRs, SHR+enalapril (SHR-E) rats, SHR+L-NAME rats, SHR+enalapril+L-NAME (SHRE+L-NAME) rats...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/28605329/immunohistochemical-profile-of-tumor-pathways-and-prognostic-significance-in-colon-adenocarcinomas
#20
Serkan Senol, Ayse Bahar Ceyran, Duygu Kösemetin, Bengü Gobanoglu, Dincer Aydin, Esra Akdeniz Duran, Metin Leblebici
The current study examined the immunohistochemical expression levels of molecules on carcinogenesis pathway and evaluated their clinicopathologic significance in colorectal adenocarcinoma (CRA). A total of 189 CRA and 20 colonic mucosal tissue samples were evaluated by immunohistochemical staining using 38 antibodies targeting the known molecules that play roles in developmental pathways of various tumors. The immunoexpression data of the patients were compared to clinicopathologic parameters. Expression loss of MLH1, MSH2, MSH6, PMS2, PTEN, Smad4 and E-cadherin, and overexpression of ALDH1, CD44, CAIX, P504S (AMACR), TGFΒ, and ZEB1 were statistically significant in CRA compared to normal colon mucosa...
2017: Journal of Environmental Pathology, Toxicology and Oncology
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