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Diabetic Medicine: a Journal of the British Diabetic Association

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https://www.readbyqxmd.com/read/27885717/salsalate-treatment-for-prediabetes-a-therapeutic-alternative
#1
S H Kim, G Reaven
Recent studies [1,2] in insulin-resistant individuals without diabetes have been unable to confirm previous findings [3] that salsalate, a non-steroidal, anti-inflammatory salicylate derivative can enhance insulin sensitivity; however, failure to improve insulin sensitivity in overweight/obese, insulin-resistant individuals without diabetes should not necessarily lead to the conclusion that salsalate is without therapeutic potential in this population. Indeed, an argument can be made that administration of salsalate may be of unique benefit to such individuals; that is, those who are overweight/obese and insulin-resistant before gross decompensation of glucose tolerance, but at increased risk of Type 2 diabetes and cardiovascular disease...
November 25, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27885706/insulin-pump-failures-in-italian-children-with-type%C3%A2-1-diabetes-retrospective-1-year-cohort-study
#2
I Rabbone, N Minuto, R Bonfanti, M Marigliano, F Cerutti, V Cherubini, G d'Annunzio, A Frongia, D Iafusco, G Ignaccolo, F Lombardo, R Schiaffini, S Toni, S Tumini, S Zucchini, A Pistorio, A E Scaramuzza
AIMS: Insulin pump failure and/or malfunction requiring replacement have not been thoroughly investigated. This study evaluated pump replacement in children and adolescents with Type 1 diabetes using insulin pump therapy. METHODS: Data were collected for all participants younger than 19 years, starting insulin pump therapy before 31 December 2013. For each child, age, disease duration, date of insulin pump therapy initiation, insulin pump model, failure/malfunction/replacement yes/no and reason were considered for the year 2013...
November 25, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27885698/long-term-excess-risk-of-stroke-in-people-with-type-2-diabetes-in-sweden-according-to-blood-pressure-level-a-population-based-case-control-study
#3
C H Stahl, M Lind, A-M Svensson, M Kosiborod, S Gudbjörnsdottir, A Pivodic, M Clements, A Rosengren
AIMS: To estimate the risk of stroke in people with Type 2 diabetes with different blood pressure levels compared with the risk in the general population in Sweden. METHODS: This prospective case-control study included 408 076 people with Type 2 diabetes, aged ≥18 years, and free of prior stroke, registered in the Swedish National Diabetes Register 1998-2011. Age- and sex-matched control subjects (n=1 913 507) without stroke from the general population were included...
November 25, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27862276/socio-economic-factors-influencing-the-development-of-end-stage-renal-disease-in-people-with-type%C3%A2-1-diabetes-a-longitudinal-population-study
#4
C Toppe, A Möllsten, S Schön, G Dahlquist
AIMS: The development of end-stage renal disease (ESRD) in Type 1 diabetes is multifactorial. Familial socio-economic factors may influence adherence to and understanding of diabetes treatment, and also general health behaviour. We investigate how parental and personal education level and exposure to low economic status, indicated by the need for income support, influence the development of ERSD caused by Type 1 diabetes. METHODS: Participants were retrieved from the nationwide Swedish Childhood Diabetes Registry, which was linked to the Swedish Renal Registry, to find people with ESRD caused by Type 1 diabetes, and to Statistic Sweden to retrieve longitudinal socio-economic data on participants and their parents...
November 18, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27862247/association-between-serum-25-oh-d3-and-cardiovascular-morbidity-and-mortality-in-people-with-type%C3%A2-2-diabetes-a-community-based-cohort-study
#5
M Samefors, R Scragg, T Länne, F H Nyström, C J Östgren
AIM: We aimed to explore the association between vitamin D and cardiovascular morbidity and mortality in people with Type 2 diabetes recruited from a community-based study because there is limited and inconsistent research of this group. METHODS: A prospective community-based cohort study among people aged 55-66 years with Type 2 diabetes as part of The Cardiovascular Risk in Type 2 Diabetes - A Prospective Study in Primary Care (CARDIPP). We analysed serum 25-hydroxyvitamin D3 [25(OH)D3 ] at baseline...
November 18, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27859562/vitamin%C3%A2-c-deficiency-and-diabetes-mellitus-easily-missed
#6
D J Christie-David, J E Gunton
Scurvy and vitamin C deficiency are usually considered to be of only historical interest. Interestingly, most animals can synthesize vitamin C, but not humans, higher primates, guinea-pigs and some bats. Deficiency results in the defective formation of collagen and connective tissues; symptoms of deficiency may include bruising, bleeding gums, petechiae, arthralgia and impaired wound healing [1,2]. This article is protected by copyright. All rights reserved.
November 18, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27859559/fut2-non-secretor-status-is-associated-with-type-1-diabetes-susceptibility-in-japanese-children
#7
K Ihara, C Fukano, T Ayabe, M Fukami, T Ogata, T Kawamura, T Urakami, N Kikuchi, I Yokota, K Takemoto, T Mukai, A Nishii, T Kikuchi, T Mori, N Shimura, G Sasaki, R Kizu, N Takubo, S Soneda, T Fujisawa, R Takaya, Z Kizaki, S Kanzaki, K Hanaki, N Matsuura, Y Kasahara, K Kosaka, T Takahashi, K Minamitani, S Matsuo, H Mochizuki, K Kobayashi, A Koike, R Horikawa, S Teno, K Tsubouchi, T Mochizuki, Y Igarashi, S Amemiya, S Sugihara
AIM: To examine the contribution of the FUT2 gene and ABO blood type to the development of Type 1 diabetes in Japanese children. METHODS: We analysed FUT2 variants and ABO genotypes in a total of 531 Japanese children diagnosed with Type 1 diabetes and 448 control subjects. The possible association of FUT2 variants and ABO genotypes with the onset of Type 1 diabetes was statistically examined. RESULTS: The se2 genotype (c.385A>T) of the FUT2 gene was found to confer susceptibility to Type 1A diabetes in a recessive effects model [odds ratio for se2/se2, 1...
November 18, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27864988/time-to-question-diabetes-self-management-support-for-arabic-speaking-migrants-exploring-a-new-model-of-care
#8
H Alzubaidi, K McNamara, C Browning
AIM: The objective of this study was to explore a new model for diabetes self-management support in Arabic-speaking migrants. METHODS: Two qualitative methods were used: face-to-face semi-structured individual interviews and focus groups. Interviews were audio-taped, transcribed verbatim and coded thematically. Arabic-speaking migrants with Type 2 diabetes were recruited from several primary, secondary and tertiary healthcare settings in metropolitan Melbourne, Australia...
November 16, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27864886/perceptions-of-risks-for-diabetes-related-complications-in-type-2-diabetes-populations-a-systematic-review
#9
T Rouyard, S Kent, R Baskerville, J Leal, A Gray
AIM: In Type 2 diabetes, there is no clear understanding of how people perceive their risk of experiencing diabetes-related complications. To address this issue, we undertook an evidence-based synthesis of how people with Type 2 diabetes perceive their risk of complications. METHODS: We performed a systematic search of nine electronic databases for peer-reviewed articles published on or before 1 March 2016. Data from 18 studies reporting lay perceptions of risks for complications in Type 2 diabetes populations were included...
November 16, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27859570/diabetes-incidence-and-prevalence-in-hong-kong-china-during-2006-2014
#10
J Quan, T K Li, H Pang, C H Choi, S C Siu, S Y Tang, N M Wat, J Woo, J M Johnston, G M Leung
AIMS: To estimate recent secular changes in the incidence and prevalence of diabetes and pre-diabetes among Hong Kong Chinese adults, and thus show possible future trends for developing mainland China. METHODS: Based on a complete census of the public sector health records of 6.4 million people from 2006 to 2014, diabetes cases were ascertained using different methods including the World Health Organization (WHO) 2011 guidelines (HbA1c , fasting plasma glucose and glucose tolerance test), American Diabetes Association (ADA) 2015 guidelines (plus random plasma glucose), and additionally recorded diagnosis codes and medication dispensation...
November 12, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27770592/circulating-adiponectin-concentration-is-inversely-associated-with-glucose-tolerance-and-insulin-secretion-in-people-with-newly-diagnosed-diabetes
#11
K S Weber, K Strassburger, G Pacini, B Nowotny, K Müssig, J Szendroedi, C Herder, M Roden
AIMS: To examine the hypothesis that changes in serum adiponectin concentration inversely relate to changes in glucose tolerance and β-cell function already during the early stage of disease progression in recently diagnosed Type 1 and Type 2 diabetes mellitus. METHODS: Participants in the prospective observational German Diabetes Study (Type 2 diabetes, n = 94; Type 1 diabetes, n =42) underwent i.v. glucose tolerance and glucagon stimulation testing to assess pre-hepatic β-cell function, glucose tolerance index and C-peptide secretion within the first year of diabetes diagnosis and 2 years later...
October 22, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27770591/economic-evaluation-of-chronic-disease-self-management-for-people-with-diabetes-a-systematic-review
#12
C Teljeur, P S Moran, S Walshe, S M Smith, F Cianci, L Murphy, P Harrington, M Ryan
AIMS: To systematically review the evidence on the costs and cost-effectiveness of self-management support interventions for people with diabetes. BACKGROUND: Self-management support is the provision of education and supportive interventions to increase patients' skills and confidence in managing their health problems, potentially leading to improvements in HbA1c levels in people with diabetes. METHODS: Randomized controlled trials, observational studies or economic modelling studies were eligible for inclusion in the review...
October 22, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27770590/higher-skin-autofluorescence-in-young-people-with-type-1-diabetes-and-microvascular-complications
#13
Y H Cho, M E Craig, A S Januszewski, P Benitez-Aguirre, S Hing, A J Jenkins, K C Donaghue
AIM: To test the hypothesis that non-invasive skin autofluorescence, a measure of advanced glycation end products, would provide a surrogate measure of long-term glycaemia and be associated with early markers of microvascular complications in adolescents with Type 1 diabetes. METHODS: Forearm skin autofluorescence (arbitrary units) was measured in a cross-sectional study of 135 adolescents with Type 1 diabetes [mean ± sd age 15.6 ± 2.1 years, diabetes duration 8...
October 22, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27770589/factors-affecting-the-benefit-of-insulin-dose-intensification-in-people-with-type-2-diabetes-an-analysis-from-the-opt2mise-randomized-trial
#14
I Schütz-Fuhrmann, J Castañeda, Y Reznik, R Aronson, I Conget, S Liabat, S Runzis, S de Portu, O Cohen
The recent OpT2mise randomized trial compared the efficacy of insulin pump therapy and multiple daily injections (MDI) in people with Type 2 diabetes and HbA1c levels that remained ≥64 mmol/mol (8.0%) despite insulin dose optimization [1,2]. During the initial 6-month randomized phase of the study, pump therapy was shown to produce a significant improvement in glycaemic control and a 20% reduction in total daily insulin dose, compared with MDI therapy [1], and these benefits were sustained during the subsequent 6-month extension phase during which all participants received pump therapy [2]...
October 22, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27770582/rd-lawrence-lecture-2015-old-habits-are-hard-to-break-lessons-from-the-study-of-hypoglycaemia
#15
REVIEW
R J McCrimmon
Despite the introduction of newer technologies and improved insulin formulations, recurrent hypoglycaemia continues to affect the lives of many people with Type 1 and Type 2 diabetes. Developing strategies or therapies designed to prevent or minimize hypoglycaemia risk is of utmost importance to help individuals safely achieve glycaemic targets. Novel, educational or behavioural approaches need to be based on a clear understanding of the mechanisms underpinning both the detection of hypoglycaemia and why repeated exposure to hypoglycaemia leads to the development of a clinical syndrome referred to as impaired awareness of hypoglycaemia...
October 22, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27761951/a-systematic-review-of-interventions-to-improve-outcomes-for-young-adults-with-type-1-diabetes
#16
REVIEW
M C O'Hara, L Hynes, M O'Donnell, N Nery, M Byrne, S R Heller, S F Dinneen
BACKGROUND: Many young adults with Type 1 diabetes experience poor outcomes. The aim of this systematic review was to synthesize the evidence regarding the effectiveness of interventions aimed at improving clinical, behavioural or psychosocial outcomes for young adults with Type 1 diabetes. METHODS: Electronic databases were searched. Any intervention studies related to education, support, behaviour change or health service organizational change for young adults aged between 15-30 years with Type 1 diabetes were included...
October 20, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27761946/profile-of-diabetes-in-men-aged-79-97-years-the-western-australian-health-in-men-study
#17
M Henze, H Alfonso, L Flicker, J George, S A P Chubb, G J Hankey, O P Almeida, J Golledge, P E Norman, B B Yeap
AIMS: To investigate behavioural, physical and biochemical characteristics associated with diabetes in the oldest age group of elderly men. METHODS: We conducted a cross-sectional analysis of community-dwelling men aged 79-97 years from Perth, Western Australia. Lifestyle behaviours, self-rated health, physical function, and fasting glucose and HbA1c levels were assessed. RESULTS: Of 1426 men, 315 had diabetes (22%). Men with diabetes were of similar age to men without (84...
October 20, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27761942/effects-of-advanced-carbohydrate-counting-guided-by-an-automated-bolus-calculator-in-type-1-diabetes-mellitus-stenoabc-a-12-month-randomized-clinical-trial
#18
E Hommel, S Schmidt, D Vistisen, K Neergaard, M Gribhild, T Almdal, K Nørgaard
AIMS: To test whether concomitant use of an automated bolus calculator for people with Type 1 diabetes carrying out advanced carbohydrate counting would induce further improvements in metabolic control. METHODS: We conducted a 12-month, randomized, parallel-group, open-label, single-centre, investigator-initiated clinical study. We enrolled advanced carbohydrate counting-naïve adults with Type 1 diabetes and HbA1c levels 64-100 mmol/mol (8.0-11.3%), who were receiving multiple daily insulin injection therapy...
October 20, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27743404/impact-of-diabetes-mellitus-on-acute-outcomes-of-percutaneous-coronary-intervention-in-chronic-total-occlusions-insights-from-a-us-multicentre-registry
#19
J R Martinez-Parachini, A Karatasakis, D Karmpaliotis, K Alaswad, F A Jaffer, R W Yeh, M Patel, J Bahadorani, A Doing, P-K Nguyen-Trong, B A Danek, J Karacsonyi, A Alame, B V Rangan, C A Thompson, Subhash Banerjee, E S Brilakis
AIM: To examine the impact of diabetes mellitus on procedural outcomes of patients who underwent percutaneous coronary intervention for chronic total occlusion. METHODS: We assessed the impact of diabetes mellitus on the outcomes of percutaneous coronary intervention for chronic total occlusion among 1308 people who underwent such procedures at 11 US centres between 2012 and 2015. RESULTS: The participants' mean ± sd age was 66±10 years, 84% of the participants were men and 44...
October 15, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27743395/validation-of-administrative-and-clinical-case-definitions-for-gestational-diabetes-mellitus-against-laboratory-results
#20
S L Bowker, A Savu, L E Donovan, J A Johnson, P Kaul
AIM: To examine the validity of International Classification of Disease, version 10 (ICD-10) codes for gestational diabetes mellitus in administrative databases (outpatient and inpatient), and in a clinical perinatal database (Alberta Perinatal Health Program), using laboratory data as the 'gold standard'. METHODS: Women aged 12-54 years with in-hospital, singleton deliveries between 1 October 2008 and 31 March 2010 in Alberta, Canada were included in the study...
October 15, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
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