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Diabetic Medicine: a Journal of the British Diabetic Association

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https://www.readbyqxmd.com/read/30019352/who-5-and-bdi-ii-are-acceptable-screening-instruments-for-depression-in-people-with-diabetes
#1
N L Rauwerda, K A Tovote, A C Peeters, R Sanderman, P M Emmelkamp, M J Schroevers, J Fleer
AIMS: To investigate the acceptability of two questionnaires, the five item WHO Well-being Index (WHO-5) and the Beck Depression Inventory II (BDI-II), which differ in length and focus, by comparing three screening groups: (1) WHO-5, (2) BDI-II and (3) WHO-5 and BDI-II. METHODS: A total of 699 individuals with diabetes were approached to participate in the study, of whom 95 completed the WHO-5, 254 completed the BDI-II and 350 completed both the WHO-5 and the BDI-II questionnaires...
July 17, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29999549/cardiovascular-autonomic-neuropathy-and-bone-metabolism-in-type-1-diabetes
#2
C S Hansen, S Theilade, M Lajer, T W Hansen, P Rossing
AIM: To investigate the association between cardiovascular autonomic neuropathy and bone metabolism in people with Type 1 diabetes. METHODS: We assessed cardiovascular autonomic neuropathy in 329 people with Type 1 diabetes according to heart rate response to deep breathing, to standing and to the Valsalva manoeuvre, and 2-min resting heart rate. More than one pathological non-resting test was defined as cardiovascular autonomic neuropathy. Bone mineral density of the femoral neck (BMDfn) was assessed by dual energy X-ray absorptiometry...
July 12, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29985535/interpretation-of-hba-1c-in-primary-care-and-potential-influence-of-anaemia-and-chronic-kidney-disease-an-analysis-from-the-copenhagen-primary-care-laboratory-coplab-database
#3
R Borg, F Persson, V Siersma, B Lind, N de Fine Olivarius, C L Andersen
AIMS: To investigate, in a large population in primary care, the relationship between fasting plasma glucose and HbA1c measurements, as well as the clinical implications of anaemia or chronic kidney disease for the interpretation of HbA1c values. METHODS: From a primary care resource, we examined HbA1c and fasting plasma glucose as well as haemoglobin and estimated GFR. We stratified observations by chronic kidney disease stage and anaemia level. The estimation of the mean fasting plasma glucose level from HbA1c alone, and from HbA1c , haemoglobin and estimated GFR, respectively, was estimated...
July 9, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29978499/determinants-of-20-year-non-progression-to-type-2-diabetes-in-women-at-very-high-risk-the-e3n-cohort-study
#4
G Fagherazzi, G Gusto, F Romana Mancini, C Dow, K Rajaobelina, B Balkau, M-C Boutron-Ruault, F Bonnet
AIMS: To identify the most important determinants associated with not developing Type 2 diabetes in women considered to be at very high risk. METHODS: Between 1995 and 2014, we followed 402 women from the E3N cohort study who were considered to be at very high risk of Type 2 diabetes based on the D.E.S.I.R. score. We then computed a classification and regression tree model to identify, among a large set of risk factors, the top risk factors associated with not having Type 2 diabetes at the end of the follow-up...
July 6, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29978496/differences-in-health-outcomes-associated-with-initial-adherence-to-oral-antidiabetes-medications-among-veterans-with-uncomplicated-type-2-diabetes-a-5-year-survival-analysis
#5
J D Gatwood, M Chisholm-Burns, R Davis, F Thomas, P Potukuchi, A Hung, C P Kovesdy
AIM: To determine the association of adherence to oral antidiabetes medication with macrovascular and microvascular complications, time to insulin therapy, revascularization, admissions, and death among veterans with uncomplicated diabetes. METHODS: This was a retrospective cohort study using the Veterans Affairs Corporate Data Warehouse to examine 159 032 veterans diagnosed with uncomplicated diabetes during 2002-2014 and starting oral antidiabetes therapy for the first time...
July 6, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29943854/interindividual-differences-in-the-clinical-effectiveness-of-liraglutide-in-type-2-diabetes-a-real-world-retrospective-study-conducted-in-spain
#6
F Gomez-Peralta, A Lecube, A Fernández-Mariño, I Alonso Troncoso, C Morales, F M Morales-Pérez, I Guler, C Cadarso-Suárez
AIMS: To study the response of clinical variables (HbA1c , body weight, lipid profile and blood pressure) over 24 months of liraglutide treatment in a real-world clinical setting, and to describe the evolution of HbA1c and body weight reduction in response to liraglutide treatment by employing generalized additive mixed models (GAMMs). METHODS: We included people aged ≥ 18 years with Type 2 diabetes mellitus that initiated liraglutide treatment between November 2011 and May 2015...
June 26, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29939439/lessons-learned-from-lifestyle-prevention-trials-in-gestational-diabetes-mellitus
#7
REVIEW
A M Egan, D Simmons
Gestational diabetes mellitus (GDM) is associated with an increased risk of adverse outcomes for mother and infant both at birth and later in life. A large body of evidence is now available relating to antenatal prevention of GDM. Overall, despite some individual trials of a variety of lifestyle interventions revealing benefit, many more have shown no effect from the second trimester onwards, even with significant gestational weight gain limitation. At-risk women often seem reluctant to engage in lifestyle changes and frequently cannot adhere to recommended interventions even within a clinical trial setting...
June 25, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29939421/the-time-lag-prior-to-the-rise-in-glucose-requirements-to-maintain-stable-glycaemia-during-moderate-exercise-in-a-fasted-insulinaemic-state-is-of-short-duration-and-unaffected-by-the-level-at-which-glycaemia-is-maintained-in-type-1-diabetes
#8
V B Shetty, P A Fournier, R J Davey, A J Retterath, N Paramalingam, H C Roby, E A Davis, T W Jones
AIMS: To determine the duration of the low hypoglycaemia risk period after the start of moderate-intensity exercise performed under basal insulinaemic conditions and whether this period is affected by the level at which glycaemia is maintained under these conditions. METHODS: This was a prospective, randomized counterbalanced study. Eight participants with Type 1 diabetes (mean ± sd age 21.5 ± 4.0 years) underwent either a euglycaemic (5-6 mmol/l) or hyperglycaemic clamp (9-10 mmol/l) on separate days and were infused with insulin at basal rates and [6,6-2 H]glucose while cycling for 40 min at 50% maximum oxygen consumption rate...
June 25, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29938852/diurnal-profile-of-interstitial-glucose-following-dexamethasone-prophylaxis-for-chemotherapy-treatment-of-gynaecological-cancer
#9
M J Lyall, I Thethy, L Steven, M MacKean, F Nussey, M Sakala, T Rye, M W J Strachan, A R Dover
AIMS: Hyperglycaemia, a side-effect of acute glucocorticoid exposure, is associated with poor outcome in those undergoing chemotherapy. The incidence, risk factors and diurnal profile of glucocorticoid-induced glucose dysregulation in the context of chemotherapy treatment remain incompletely understood. METHODS: Blinded continuous interstitial glucose monitoring was performed on 16 women without diabetes for 24 h prior to and 5 days following carboplatin/paclitaxel chemotherapy combined with dexamethasone treatment for gynaecological cancer...
June 25, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29938825/maternal-insulin-resistance-triglycerides-and-cord-blood-insulin-are-not-determinants-of-offspring-growth-and-adiposity-up-to-5-years-a-follow-up-study
#10
D M Meyer, C Brei, L Stecher, S Brunner, H Hauner
AIMS: Metabolic dysregulation in utero may influence fetal metabolism and early growth. We previously investigated relationships between maternal indices of glucose homeostasis and triglycerides as well as cord blood insulin with offspring anthropometry up to 2 years. The aim of this analysis was to follow these relationships up to the age of 5 years. METHODS: Associations between maternal metabolic variables of glucose and lipid metabolism measured at 32 weeks' gestation and cord blood insulin with growth and body composition of 162 offspring aged 3-5 years were explored...
June 25, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29932243/improving-outcomes-in-gestational-diabetes-does-gestational-weight-gain-matter
#11
C E M Aiken, L Hone, H R Murphy, C L Meek
AIM: Excessive gestational weight gain increases risk of gestational diabetes mellitus (GDM) but it remains unclear whether weight control after GDM diagnosis improves outcomes. We assessed whether: (1) total gestational weight gain during pregnancy (0-36 weeks); (2) early gestational weight gain (0-28 weeks, before GDM diagnosis); or (3) late gestational weight gain (28-36 weeks, after diagnosis) are associated with maternal-fetal outcomes. METHODS: Some 546 women with GDM who delivered viable singleton infants at a single UK obstetric centre (October 2014 to March 2017) were included in this retrospective observational study...
June 22, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29931809/sex-differences-in-coronary-plaque-composition-evaluated-by-coronary-computed-tomography-angiography-in-newly-diagnosed-type-2-diabetes-association-with-low-grade-inflammation
#12
M Mrgan, J Gram, M Hecht Olsen, D Dey, B Linde Nørgaard, J Gram, N P Rønnow Sand
AIM: To determine differences in coronary plaque composition and inflammatory biomarkers between men and women with newly diagnosed Type 2 diabetes without known cardiovascular disease. METHODS: A total of 88 people with newly diagnosed (<1 year) Type 2 diabetes underwent contrast-enhanced coronary computed tomography angiography. Advanced coronary plaque analysis was performed using semi-automated software. Plasma concentrations of inflammatory biomarkers were determined...
June 22, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29931731/variations-in-access-to-and-reimbursement-for-continuous-glucose-monitoring-systems-for-people-living-with-type-1-diabetes-across-england
#13
R Perera, N Oliver, E Wilmot, C Marriott
Since the introduction of real-time continuous glucose monitoring (CGM) systems more than 15 years ago and, more recently, flash glucose monitoring (Flash-GM), clinical studies have observed reductions in HbA1c , independent of insulin delivery method, with decreasing time spent in hypoglycaemia [1] and reduction in glycaemic variability [2]. CGM can improve quality of life and reduce diabetes-related distress [3], including fear of hypoglycaemia [4,5]. Despite these benefits, CGM has yet to be fully implemented as part of the standard of care for people living with Type 1 diabetes in England, and there is considerable variation in how it is funded through local payer organizations...
June 22, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29923215/self-management-of-diabetes-in-hospital-a-guideline-from-the-joint-british-diabetes-societies-jbds-for-inpatient-care-group
#14
D Flanagan, K Dhatariya, A Kilvert
The aims of these guidelines are to improve the inpatient experience and safety for people with diabetes through effective self-management. The guidelines are aimed primarily at healthcare professionals working in hospitals, although some aspects are relevant to staff involved in pre-admission preparation. The guidelines suggest an approach to providing patient information, the circumstances in which self-management is appropriate, the development of care plans and the elements needed for effective self-management...
June 19, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29908085/body-mass-index-and-the-risk-of-mortality-among-chinese-adults-with-type-2-diabetes
#15
H Xu, M Zhang, D Xu, F Zhang, B Yao, Y Yan, N Zhao, W Xu, G Qin
AIMS: To examine the associations between BMI and the risks of all-cause, cardiovascular disease (CVD)-specific and cancer-specific mortality among people with Type 2 diabetes, and thus provide recommendations for weight management in the population. METHODS: This retrospective cohort study was conducted among 52 763 people with newly diagnosed Type 2 diabetes between 1 January 2004 and 31 December 2014 in Shanghai, China. All cases of death were identified by linking to the Shanghai Vital Statistics...
June 16, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29908078/ultrasound-detection-of-insulin-induced-lipohypertrophy-in-type-1-and-type-2-diabetes
#16
J E Kapeluto, B W Paty, S D Chang, G S Meneilly
AIMS: To define standard criteria for the detection of lipohypertrophy using ultrasonography and to determine the accuracy of this method. METHOD: Individuals using insulin therapy for ≥2 years with unknown lipohypertrophy status were enrolled at a diabetes education centre. A team of diabetes educator nurses performed a clinical examination for evidence of lipohypertrophy and a separate team of ultrasonographers examined participants in a blinded fashion. RESULTS: The echo signature for lipohypertrophy consisted of location in the subcutaneous layer and lesions that were 1) well circumscribed either by hyperechoic foci with defined borders or a nodular shape with a hypoechoic halo, 2) heterogeneous in echotexture compared with surrounding tissue, 3) associated with distortion of surrounding connective tissue with 4) absence of vascularity and 5) absence of capsule...
June 16, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29908076/diabetes-associated-with-immune-checkpoint-inhibition-presentation-and-management-challenges
#17
A Galligan, W Xu, S Fourlanos, A Nankervis, C Chiang, A M Mant, P Parente, D Rischin, B Krishnamurthy, S Sandhu, P G Colman
BACKGROUND: In recent years, immune checkpoint blockade has become a standard therapy for a wide range of cancers. Adverse events including endocrinopathies result from the induction of autoimmunity. CASE REPORT: We report a case series of nine individuals who presented with immunotherapy-induced type 1 diabetes between 2015-2017. DISCUSSION: Onset of diabetes occurred within 12 weeks of commencing therapy. Anti- GAD antibodies were present in six people...
June 16, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29908070/prediabetes-and-diabetes-are-both-risk-factors-for-adverse-outcomes-in-infective-endocarditis
#18
X-B Wei, Y-H Liu, J-L Huang, X-L Chen, D-Q Yu, N Tan, J-Y Chen, P-C He
AIM: Diabetes is a risk factor in infective endocarditis. However, few studies have focused on the prognostic value of prediabetes in infective endocarditis. This analysis aimed to explore the relationship between prediabetes and outcomes for people with infective endocarditis. METHODS: Diabetes and prediabetes definitions were based on the American Diabetes Association 2014 criteria. A total of 866 people who had been consecutively diagnosed with infective endocarditis between January 2009 and July 2015 were included in the analysis...
June 16, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29901829/the-relationship-of-type-1-diabetes-self-management-barriers-to-child-and-parent-quality-of-life-a-us-cross-sectional-study
#19
N Saoji, M Palta, H N Young, M A Moreno, V Rajamanickam, E D Cox
AIM: Families of children and adolescents with Type 1 diabetes experience self-management challenges that negatively impact diabetes control. This study assesses whether self-management challenges are also associated with quality of life (QOL) for children and adolescents with Type 1 diabetes and their parents. METHODS: Children aged 8-12 years (n = 135), adolescents aged 13-16 years (n = 132) and their parents completed QOL assessments (diabetes-specific QOL from the PedsQL Diabetes Module or the Family Impact Module, both scaled 0-100) and a validated survey of up to six self-management barriers [PRISM; scaled 1 (low) to 5 (high)]...
June 14, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29901826/use-of-point-of-care-hba-1c-measurement-to-estimate-the-level-of-undiagnosed-diabetes-mellitus-among-67-year-old-participants-in-a-cardiovascular-screening-programme-in-the-municipality-of-viborg-denmark
#20
J W Andersen, M Dahl, K B Yderstraede, A Hoegh
AIMS: To determine the prevalence of unidentified diabetes mellitus among 67-year-olds in Denmark participating in a screening programme focusing on cardiovascular disease and diabetes, and to describe glycaemic levels in individuals according to point-of-care HbA1c combined with self-reported diabetes status. METHODS: In this cross-sectional, retrospective, population-based study, all people aged 67 years living in the Viborg municipality were invited to take part in the Viborg Inter-sectorial Screening Programme (VISP), which focuses on cardiovascular disease and diabetes...
June 14, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
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