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Diabetic Medicine: a Journal of the British Diabetic Association

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https://www.readbyqxmd.com/read/29791761/nerve-action-potential-amplitudes-a-robust-marker-of-diabetic-peripheral-neuropathy
#1
Marie Monlun, Marie Hugo, Laurence Blanco, Kamel Mohammedi, Ahdab Rechdi, Laure Alexandre, Stéphane Poirot-Mazeres, Kalina Rajaobelina, Vincent Rigalleau
We were interested in the recent publication of Peterson et al. (1) who reported a progressive reduction of sural nerve amplitudes from 10.9μV to 7.0μV, during a ten year follow-up of 87 people with varying degrees of glucose intolerance. This reduction was more pronounced for people whose glucose tolerance deteriorated during the follow-up period, and paralleled their increasing HbA1c. In contrast, nerve conduction velocities only decreased from 47.6 to 45.8 m/s, without any significant relation to HbA1c This article is protected by copyright...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29791054/incidence-of-childhood-type-1-diabetes-mellitus-in-crete
#2
D Mamoulakis, F Vrouvaki, V Louvari, E Galanakis
AIM: To investigate the epidemiology of childhood Type 1 diabetes mellitus in Crete over the last 25 years and to evaluate incidence trends over time. METHODS: The study included all children aged 0-14 years who live in Crete and were diagnosed during the 25-year period from 1 January 1992 to 31 December 2016. RESULTS: A total of 271 children were diagnosed with Type 1 diabetes during the 25-year period: 148 boys and 123 girls (boy:girl ratio 1...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29791040/presence-of-chronic-diabetic-foot-ulcers-is-associated-with-more-frequent-and-more-advanced-retinopathy
#3
A Sellman, P Katzman, S Andreasson, M Löndahl
AIMS: To clarify the frequency and severity of diabetic retinopathy in a group of people with Type 2 diabetes and chronic diabetic foot ulcers, and to compare visual acuity, levels of retinopathy and clinical significant macular oedema with a matched control group of people with Type 2 diabetes without a history of chronic diabetic foot ulcers. METHODS: Visual acuity and fundus imaging were evaluated in 90 white people with at least 3 months' duration of full-thickness diabetic foot ulcers below the ankle and the results compared with those in 180 white people with Type 2 diabetes without a history of chronic diabetic foot ulcers (control group)...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29791033/diabetes-related-lower-extremity-complications-are-a-leading-cause-of-the-global-burden-of-disability
#4
P A Lazzarini, R E Pacella, D G Armstrong, J J van Netten
Globally ~435 million people have diabetes [1], and an estimated 19-34% (~83-148 million people) of those will be expected to develop foot ulcers in their lifetime [2]. Foot ulcers are typically precipitated by other diabetes-related lower-extremity complications, (DRLECs) including peripheral neuropathy and peripheral vascular disease [2,3]. Collectively, DRLECs are a leading cause of infection, hospitalization and amputation outcomes [2-5], yet, these outcomes are readily preventable with evidence-based care [6,7]...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29790603/hyperkalaemia-in-people-with-diabetes-occurrence-risk-factors-and-outcomes-in-a-danish-population-based-cohort-study
#5
R W Thomsen, S K Nicolaisen, K Adelborg, E Svensson, P Hasvold, E Palaka, L Pedersen, H T Sørensen
AIMS: To examine the incidence, risk factors and clinical outcomes of hyperkalaemia in people with diabetes in a real-world setting. METHODS: Using Danish health registries, we identified a population-based cohort of people with first-time drug-treated diabetes, in the period 2000-2012. First, the cumulative incidence of hyperkalaemia, defined as first blood test with potassium level >5.0 mmol/l after diabetes treatment initiation, was ascertained. Second, in a case-control analysis, risk factors were compared in people with vs without hyperkalaemia...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29790596/rivaroxaban-for-stroke-prevention-in-people-with-atrial-fibrillation-and-diabetes-mellitus
#6
Y-G Li, Daniele Pastori, G Y H Lip
Atrial fibrillation (AF) is associated with various cardiovascular comorbidities, such as hypertension, heart failure and diabetes mellitus, which increases not only the risk of ischaemic stroke but also of myocardial infarction and mortality. Oral anticoagulation for stroke prevention is the cornerstone of management for people with AF, both with vitamin K antagonists, or with non-vitamin K antagonist oral anticoagulants (NOACs), which show efficacy, safety and convenience compared with vitamin K antagonists [1]...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29790594/barriers-to-and-enablers-of-diabetic-retinopathy-screening-attendance-a-systematic-review-of-published-and-grey-literature
#7
E Graham-Rowe, F Lorencatto, J G Lawrenson, J M Burr, J M Grimshaw, N M Ivers, J Presseau, L Vale, T Peto, C Bunce, J J Francis
AIMS: To identify and synthesize studies reporting modifiable barriers/enablers associated with retinopathy screening attendance in people with Type 1 or Type 2 diabetes, and to identify those most likely to influence attendance. METHODS: We searched MEDLINE, EMBASE, PsycINFO, Cochrane Library and the 'grey literature' for quantitative and qualitative studies to February 2017. Data (i.e. participant quotations, interpretive summaries, survey results) reporting barriers/enablers were extracted and deductively coded into domains from the Theoretical Domains Framework; with domains representing categories of theoretical barriers/enablers proposed to mediate behaviour change...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29790218/lost-in-transition-finding-a-path-forward-for-young-adults-with-type-1-diabetes
#8
L Laffel
In this issue of Diabetic Medicine, Kellett and colleagues describe the experiences of young persons with Type 1 diabetes in the UK as their needs and self-care efforts for diabetes management evolve during the university years [1]. In the 21st century, the topic of transitions in care for young people with various chronic diseases, in general, and with Type 1 diabetes, in particular, has become a popular and appealing area for cross-sectional, observational and interventional research globally [2]. Similarly, a number of national and international organizations have published clinical guidelines related to transition, although many of the clinical recommendations are based upon expert consensus rather than empirical data [3-7]...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29790205/hyperkalaemia-in-diabetes-a-silent-risk-predicting-poor-outcomes
#9
F K Dojki, G L Bakris
Hyperkalaemia is traditionally defined as serum potassium levels >5.5 mmol/l and is associated with an elevated risk of adverse events and mortality. The renin angiotensin aldosterone system plays a pivotal role in potassium regulation [1,2], with aldosterone being a major regulator of potassium balance in the kidney.Potassium excretion and balance is primarily handled by the kidney (90%) and 10% by the colon [2]; thus, the risk of hyperkalaemia is linked to the following factors: level of kidney function; dietary potassium intake; concomitant diseases that affect potassium balance, such as diabetes; and use of medications that influence potassium excretion...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29782669/prevalence-of-active-charcot-disease-in-the-east-midlands-of-england
#10
L Metcalf, M Musgrove, J Bentley, R Berrington, D Bunting, M Mousley, J Thompson, M Sprengel, V Turtle-Savage, F Game, W Jeffcoate
AIMS: To undertake a prospective point prevalence study of the prevalence of active Charcot neuro-inflammatory osteoarthropathy (Charcot disease) in a circumscribed part of England and to audit the time elapsing between disease onset and first diagnosis. METHODS: The prevalence of active Charcot disease of the foot during a single month was assessed by specialist foot care teams at seven secondary care services in the East Midlands region of England. RESULTS: A total of 90 cases were identified, representing 4...
May 21, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29781558/characteristics-of-high-and-low-risk-individuals-in-the-priority-study-urinary-proteomics-and-mineralocorticoid-receptor-antagonism-for-prevention-of-diabetic-nephropathy-in-type-2-diabetes
#11
N Tofte, M Lindhardt, K Adamova, J Beige, J W J Beulens, A L Birkenfeld, G Currie, C Delles, I Dimos, L Francová, M Frimodt-Møller, P Girman, R Göke, T Havrdova, A Kooy, H Mischak, G Navis, G Nijpels, M Noutsou, A Ortiz, A Parvanova, F Persson, P L Ruggenenti, F Rutters, I Rychlík, G Spasovski, M Speeckaert, M Trillini, H von der Leyen, P Rossing
AIM: To compare clinical baseline data in individuals with Type 2 diabetes and normoalbuminuria, who are at high or low risk of diabetic kidney disease based on the urinary proteomics classifier CKD273. METHODS: We conducted a prospective, randomized, double-blind, placebo-controlled international multicentre clinical trial and observational study in participants with Type 2 diabetes and normoalbuminuria, stratified into high- or low-risk groups based on CKD273 score...
May 21, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29766568/cord-blood-insulin-igf-i-igf-ii-leptin-adiponectin-and-ghrelin-and-their-associations-with-insulin-sensitivity-%C3%AE-cell-function-and-adiposity-in-infancy
#12
D L Zhang, Q Du, A Djemli, P Julien, W D Fraser, Z C Luo
AIM: Vulnerability to insulin resistance and Type 2 diabetes may originate in early life, but little is known about whether any perinatal biomarkers are predictive of later metabolic health. We sought to assess whether cord blood insulin, insulin-like growth factor (IGF)-I, IGF-II, leptin, adiponectin and ghrelin are associated with metabolic health indicators in infancy. METHODS: In a prospective singleton birth cohort, we assessed cord blood insulin, IGF-I, IGF-II, leptin, adiponectin and ghrelin concentrations in relation to the homeostasis model assessment of insulin resistance (HOMA-IR), β-cell function (HOMA-β), fasting proinsulin-to-insulin ratio, BMI z-score, and the sum of triceps and subscapular skinfold thickness (an indicator of adiposity) in infants at age 1 year (n = 185)...
May 15, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29766565/a-retrospective-observational-study-of-people-with-type-1-diabetes-with-self-reported-severe-hypoglycaemia-reveals-high-level-of-ambulance-attendance-but-low-levels-of-therapy-change-and-specialist-intervention
#13
B C T Field, R Nayar, A Kilvert, M Baxter, J Hickey, M Cummings, S C Bain
AIM: To evaluate the impact of severe hypoglycaemia on NHS resources and overall glycaemic control in adults with Type 1 diabetes. METHODS: An observational, retrospective study of adults (aged ≥ 18 years) with Type 1 diabetes reporting one or more episodes of severe hypoglycaemia during the preceding 24 months in 10 NHS hospital diabetes centres in England and Wales. The primary outcome was healthcare resource utilization associated with severe hypoglycaemia...
May 15, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29766563/the-effects-of-gestational-diabetes-mellitus-on-fetal-growth-and-neonatal-birth-measures-in-an-african-cohort
#14
S Macaulay, R J Munthali, D B Dunger, S A Norris
AIM: Fetal exposure to gestational diabetes mellitus (GDM) is said to alter fetal growth and increase the risk of macrosomia. However, little research on GDM exists in African populations. This study aimed to assess longitudinal fetal growth and neonatal birth measures among Black African babies exposed to GDM. METHODS: Pregnant women (Soweto, South Africa) enrolled into a cohort study were followed up with repeated fetal ultrasounds. At 24-28 weeks' gestation a 2-h 75 g oral glucose tolerance test was performed and GDM was diagnosed using the World Health Organization's 2013 criteria...
May 15, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29766560/further-options-for-treating-lipids-in-people-with-diabetes-targeting-ldl-cholesterol-and-beyond
#15
REVIEW
A S Wierzbicki
Diabetes is associated with increased cardiovascular disease (CVD) risk. Previous studies with statins have established that a 1 mmol/l reduction in LDL-cholesterol reduces CVD events by 21% over 5 years in people with diabetes. More recently, trials in people with acute coronary syndromes showed that ezetimibe reduced CVD events by 6% at 5 years and achieved a LDL-cholesterol of 1.6 mmol/l with better results in people with Type 2 diabetes. Several novel lipid-lowering therapies have recently been developed...
May 15, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29763980/arterial-stiffness-in-people-with-type-2-diabetes-and-obstructive-sleep-apnoea
#16
M Hvelplund Kristiansen, A M Banghøj, E Laugesen, L Tarnow
AIMS: To examine whether people with Type 2 diabetes with concurrent obstructive sleep apnoea have increased arterial stiffness as compared with people with Type 2 diabetes without obstructive sleep apnoea. METHODS: In a study with a case-control design, 40 people with Type 2 diabetes and treatment-naïve moderate to severe obstructive sleep apnoea (Apnoea-Hypopnoea Index ≥15) and a control group of 31 people with Type 2 diabetes without obstructive sleep apnoea (Apnoea-Hypopnoea Index <5) were examined...
May 15, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29744920/diabetes-and-ischaemic-stroke-outcome
#17
E L MacDougal, W H Herman, J J Wing, L B Morgenstern, L D Lisabeth
AIM: To compare all-cause mortality, stroke recurrence and functional outcomes in people who have experienced stroke, with and without diabetes. METHODS: We captured data on population-based ischaemic strokes (2006-2012) in Nueces County, Texas. Data were collected from participant interviews and medical records. Differences in cumulative mortality and stroke recurrence risk by diabetes status were estimated at 30 days and 1 year using Cox models. Differences in 90-day functional outcomes (activities of daily living/instrumental activities of daily living score: range 1-4; higher scores worse) by diabetes status were assessed using Tobit regression...
May 9, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29738609/potential-of-electric-bicycles-to-improve-the-health-of-people-with-type-2-diabetes-a-feasibility-study
#18
A R Cooper, B Tibbitts, C England, D Procter, A Searle, S J Sebire, E Ranger, A S Page
AIM: To explore in a feasibility study whether 'e-cycling' was acceptable to, and could potentially improve the health of, people with Type 2 diabetes. METHODS: Twenty people with Type 2 diabetes were recruited and provided with an electric bicycle for 20 weeks. Participants completed a submaximal fitness test at baseline and follow-up to measure predicted maximal aerobic power, and semi-structured interviews were conducted to assess the acceptability of using an electric bicycle...
May 8, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29737587/the-glycaemic-benefits-of-a-very-low-carbohydrate-ketogenic-diet-in-adults-with-type-1-diabetes-mellitus-may-be-opposed-by-increased-hypoglycaemia-risk-and-dyslipidaemia
#19
Z Z X Leow, K J Guelfi, E A Davis, T W Jones, P A Fournier
AIMS: To investigate whether very-low-carbohydrate high-fat diets, typical of ketogenic diets, can improve glycaemic control without causing any ill health effects in adults with Type 1 diabetes. METHODS: In this observational study, 11 adults with Type 1 diabetes (seven men, four women, mean ± sd age 36.1± 6.8 years, mean ± sd duration of diabetes 12.8 ± 10.3 years), who followed a ketogenic diet (< 55 g carbohydrate per day) for a mean ± sd of 2.6 ± 3...
May 8, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29729055/younger-people-with-type-2-diabetes-have-poorer-self-care-practices-compared-with-older-people-results-from-the-australian-national-diabetes-audit
#20
N Nanayakkara, A J Pease, S Ranasinha, N Wischer, S Andrikopoulos, B de Courten, S Zoungas
AIM: This cross-sectional study compares the self-care practices of younger and older people with Type 2 diabetes. METHODS: Data were analysed from the Australian National Diabetes Audit (ANDA) including 2552 adults with Type 2 diabetes from Australian Diabetes Centres. Pre-specified demographic and clinical variables were obtained. Self-care variables (physical activity, following dietary recommendations, medication adherence and monitoring blood glucose levels) were compared in people ≤ 64 and > 64 years of age...
May 5, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
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