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Diabetic Medicine: a Journal of the British Diabetic Association

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https://www.readbyqxmd.com/read/28430381/continuous-subcutaneous-insulin-infusion-csii-therapy-at-derby-teaching-hospitals-sustained-benefits-in-glucose-control
#1
U Anyanwagu, H Olaoye, P Jennings, S Ashton-Cleary, S Sugunendran, D Hughes, I Idris, E G Wilmot
AIM: In the short term, continuous subcutaneous insulin infusion (CSII) has been associated with improved glycaemic control, reduced hypoglycaemia and improved quality of life (QOL). However, limited data are available on its long-term benefits, particularly in the UK. We aimed to assess the impact of CSII on longer term outcomes. METHOD: Patient-level data were obtained for CSII users at Derby Teaching Hospitals, UK. Patient confidence and satisfaction questionnaires using the Likert scale were used to assess confidence in self-management...
April 21, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28430377/exploring-why-young-people-with-type%C3%A2-1-diabetes-decline-structured-education-with-a-view-to-overcoming-barriers
#2
V E Coates, G Horigan, M Davies, M T Davies
AIMS: To identify factors that influence lack of engagement of young adults with Type 1 diabetes (aged 13-21 years) with structured diabetes education (SDE) to inform and broaden the reach of future SDE. METHODS: A quantitative, cross-sectional survey was undertaken of 227 young people with Type 1 diabetes drawn from 11 health trusts across Northern Ireland and England, deemed to be representative of the wider population. Participants were asked to complete a questionnaire exploring non-attendance, along with the Diabetes Care Profile, the Diabetes Empowerment Scale (Short Form), the Diabetes Knowledge Test and the 12-item General Health Questionnaire...
April 21, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28430372/retinal-nerve-fibre-layer-thickness-is-reduced-in-metabolic-syndrome
#3
R Zarei, P Anvari, Y Eslami, G Fakhraie, M Mohammadi, A Jamali, M Afarideh, A Ghajar, S Heydarzade, A Esteghamati, S Moghimi
AIMS: To investigate retinal nerve fibre layer (RNFL) thickness in people with metabolic syndrome (MetS) and healthy controls. METHODS: A cross-sectional study was performed from March 2014 to January 2016. All participants underwent anthropometric and serological biochemical measurements, ophthalmological examination, and spectral-domain optical coherence tomography (SD-OCT). Individuals with elevated intraocular pressure, glaucoma, diabetic retinopathy and other ocular disorders were excluded...
April 21, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28429491/bringing-the-human-pancreas-into-focus-new-paradigms-for-the-understanding-of-type-1-diabetes
#4
REVIEW
N G Morgan
Type 1 diabetes affects increasingly large numbers of people globally (including at least half a million children under the age of 14 years) and it remains an illness with life-long and often devastating consequences. It is surprising, therefore, that the underlying aetiology of Type 1 diabetes remains poorly understood. This is largely because the cellular and molecular processes leading to the loss of β cells in the pancreas have rarely been studied at, or soon after, the onset of disease. Where such studies have been undertaken, a number of surprises have emerged which serve to challenge conventional wisdom...
April 20, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28419565/evolution-of-silent-myocardial-ischaemia-prevalence-and-cardiovascular-disease-risk-factor-management-in-type-2-diabetes-over-a-10-year-period-an-observational-study
#5
A Sultan, F Perriard, V Macioce, D Mariano-Goulart, C Boegner, J-P Daures, A Avignon
AIMS: To assess the evolution of silent myocardial ischaemia prevalence and of cardiovascular disease risk factor management over 10 years in people with Type 2 diabetes. METHODS: This repeated cross-sectional study prospectively included 770 people with Type 2 diabetes who presented at our centre in the period 1999-2009. All had at least one additional cardiovascular disease risk factor, no history of coronary disease and were screened for silent myocardial ischaemia using myocardial perfusion imaging...
April 18, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28393407/haemoglobin%C3%A2-a1c-interpretation-more-than-mean-blood-glucose-to-be-considered
#6
W G John
It is more than half a century since Kunkel and Wallenius described the occurrence of 'minor components' in normal adult haemoglobin in the absence of variants [1]; the major fraction of these components was identified as glucose attached to the haemoglobin molecule, and is now termed HbA1c . The importance of this HbA1c did not become fully apparent until 1969 when Rahbar and associates [2] described 'an abnormal fast moving haemoglobin fraction' in the erythrocytes of people with diabetes; hence the relationship of HbA1c to diabetes was established, and within 10 years, methods for measuring this fraction were being introduced into clinical laboratory practice [3]...
April 10, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28391607/children-s-experiences-of-managing-type%C3%A2-1-diabetes-in-everyday-life-a-thematic-synthesis-of-qualitative-studies
#7
D Rankin, J Harden, R Jepson, J Lawton
AIMS: To explore the everyday experiences of children (aged ≤ 12 years) with Type 1 diabetes to identify factors that help or hinder diabetes self-management practices. METHODS: Eight databases (Embase, Medline, CINAHL, Web of Science, PsychInfo, ASSIA, ERIC and ProQuest Dissertations) were searched in 2016 to identify qualitative studies exploring children's views about self-managing diabetes. Data were extracted, coded and analysed using thematic synthesis...
April 9, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28375568/fludrocortisone-therapy-for-persistent-hyperkalaemia
#8
S J H Dobbin, J R Petrie, M E J Lean, G A McKay
Hyperkalaemia is often seen in individuals with renal impairment and may be exacerbated, particularly in diabetic nephropathy, by hyporeninaemic aldosterone deficiency (type 4 renal tubular acidosis) which may, in turn, be caused or complicated by chronic interstitial nephritis or drug therapy (Table 1). Fludrocortisone is a synthetic corticosteroid with mineralocorticoid activity that increases sodium resorption and promotes potassium excretion in the distal convoluted renal tubule. It therefore seems a logical option to reverse hyperkalaemia in type 4 renal tubular acidosis; however, we can find no published guideline recommending this use [1,2]...
April 4, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28375555/associations-of-mortality-and-cardiovascular-disease-risks-with-diabetes-and-albuminuria-in-urban-indigenous-australians-the-druid-follow-up-study
#9
E L M Barr, J Cunningham, S Tatipata, T Dunbar, N Kangaharan, S Guthridge, S Qin Li, J R Condon, J E Shaw, K O'Dea, L J Maple-Brown
AIM: To assess the relationships of diabetes and albuminuria with all-cause mortality and cardiovascular disease outcomes in a population without prior cardiovascular disease using data from the Darwin Region Urban Indigenous Diabetes (DRUID) study. METHODS: We conducted a prospective cohort study of 706 participants (aged 15-81 years, 68% women) without prior cardiovascular disease who underwent a 75-g oral glucose tolerance test. Deaths and fatal or non-fatal cardiovascular disease were determined over 7 years, and hazard ratios with 95% CIs and population attributable risks were estimated for baseline glycaemia and albuminuria...
April 4, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28375545/screening-for-diabetic-retinopathy-in-children-and-young-people-in-the-uk-potential-gaps-in-ascertainment-of-those-at-risk
#10
M C Ibanez-Bruron, A L Solebo, P M Cumberland, J S Rahi
Guidelines in the UK recommend that children and young people living with Type 1 and Type 2 diabetes undergo annual screening for diabetic retinopathy from the age of 12 years [1]. This is currently delivered though a large number of regional diabetic eye screening programmes that are responsible for identifying eligible children and young people, and inviting them to a screening appointment (Fig. 1). In 2014/2015, the National Paediatric Diabetes Audit, based on secondary (hospital-based) care data for over 27 600 children, revealed that only 64% of eligible children and young people in England had been recorded as having undergone diabetic retinopathy screening during the last audit year; of whom, 13% were reported to have at least background diabetic retinopathy [2]...
April 4, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28370335/challenges-faced-by-physicians-when-discussing-the-type%C3%A2-2-diabetes-diagnosis-with-patients-insights-from-a-cross-national-study-introdia-%C3%A2
#11
M Capehorn, W H Polonsky, S Edelman, A Belton, S Down, V Gamerman, F Nagel, J Lee, A Alzaid
AIMS: To investigate physicians' recalled experiences of their conversations with patients at diagnosis of Type 2 diabetes, because physician-patient communication at that time may influence the patient's subsequent self-care and outcomes. METHODS: As part of a large cross-national study of physician-patient communication during early treatment of Novo 2017 Charles Fox v2 Type 2 diabetes (IntroDia(®) ), we conducted a cross-sectional survey of physicians treating people with Type 2 diabetes in 26 countries across Africa, Asia, Europe, Latin America, the Middle East, North America and Oceania...
March 28, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28370329/glutamic-acid-decarboxylase-and-islet-antigen%C3%A2-2-antibody-profiles-in-people-with-adult-onset-diabetes-mellitus-a-comparison-between-mixed-ethnic-populations-in-singapore-and-germany
#12
Y H Ong, W C A Koh, M L Ng, Z Y Tam, S C Lim, B O Boehm
AIM: To gain insight into the presence of islet cell autoimmunity in an ethnic Asian compared with a white European population. METHODS: For this cross-sectional study we recruited people with adult-onset diabetes (age of diagnosis 20-60 years), at tertiary referral centres in Germany (n=1020) and Singapore (n=1088). Glutamic acid decarboxylase and islet antigen 2 antibodies were measured according to Islet Autoantibody Standardization Program protocols. RESULTS: The prevalence of glutamic acid decarboxylase antibody positivity was 13...
March 28, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28370237/a-comparison-of-hba1c-concentration-in-people-with-type-2-diabetes-at-sea-level-and-high-altitude-in-china-an-observational-study
#13
L Zhou, L Yang, X Zhou, X Lv, J Song, S Meng, J Yue, S Yang, L Ji
Glucose combines with haemoglobin via a slow irreversible non-enzymatic reaction, and the rate of glycation is determined by serum glucose concentration; therefore, the percentage of HbA1c is used to monitor blood glucose control in diabetes [1]. The assumption, however, that HbA1c is equal to mean glucose concentration ignores the variation in erythrocyte levels among individuals. In addition to the rate of glycation, HbA1c also depends on the time taken for glycation, which in turn depends on the age of the red blood cells (RBCs) [2]...
March 28, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28326628/incidence-recurrence-and-cost-of-hyperglycaemic-crises-requiring-emergency-treatment-in-andalusia-spain
#14
R J Barranco, F Gomez-Peralta, C Abreu, M Delgado-Rodriguez, A Moreno-Carazo, F Romero, M A de la Cal, J M Barranco, F J Pasquel, G E Umpierrez
AIMS: Hyperglycaemic crises (diabetic ketoacidosis and hyperosmolar hyperglycaemic state) are medical emergencies in people with diabetes. We aimed to determine their incidence, recurrence and economic impact. METHODS: An observational study of hyperglycaemic crises cases using the database maintained by the out-of-hospital emergency service, the Healthcare Emergency Public Service (EPES) during 2012. The EPES provides emergency medical services to the total population of Andalusia, Spain (8...
March 22, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28326618/comparative-study-of-hba1c-and-fasting-plasma-glucose-vs-the-oral-glucose-tolerance-test-for-diagnosis-of-diabetes-in-people-with-tuberculosis
#15
H Aftab, A Ambreen, M Jamil, P Garred, J H Petersen, S D Nielsen, I C Bygbjerg, D L Christensen
AIM: To compare HbA1c and fasting plasma glucose assessment, with the 2-h oral glucose tolerance test as reference, in screening for diabetes in people with turberculosis. METHODS: Individuals (N=268) with newly diagnosed smear-positive tuberculosis were screened for diabetes at a tertiary hospital in Lahore, Pakistan. Diabetes diagnosis was based on WHO criteria: thresholds were ≥ 48 mmol/mol (≥6.5%) for HbA1c and ≥7.0mmol/l for fasting plasma glucose. RESULTS: The proportion of participants diagnosed with diabetes was 4...
March 22, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28326603/response-to-early-view-an-opportunity-for-enhanced-peer-review
#16
Tonja Nansel, Aiyi Liu, Benjamin Gee
We welcome the anonymous readers' interest in our advance-access manuscript, and appreciate the opportunity to respond to the Editor's comments on our article as it reaches the Journal's pages in print. First, the Editor suggests 'it may be incorrect to state that the intervention led to a reduction in hypoglycaemia rates' because the study did not report the change in hypoglycaemia rates from baseline. The aim of our study was to compare rates of adverse events between intervention and control groups during the course of the trial...
March 22, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28321905/differential-increments-of-basal-glucagon-like-1-peptide-concentration-among-slc47a1-rs2289669-genotypes-were-associated-with-inter-individual-variability-in-glycaemic-response-to-metformin-in-chinese-people-with-newly-diagnosed-type-2-diabetes
#17
H Liang, W Xu, L Zhou, W Yang, J Weng
AIM: To elucidate the effects of rs2289669, an intron variant of the SLC47A1 gene, on glucose response to metformin in Chinese people with newly diagnosed Type 2 diabetes. METHODS: Rs2289669 was genotyped, using Sequenom, in 291 participants receiving 48 weeks of metformin monotherapy. The changes in HbA1c were compared among rs2289669 genotypes, and associations with rs2289669 were evaluated using linear regression analysis. RESULTS: We found that, compared with participants with a homozygous G allele, those carrying the minor A allele had significantly greater HbA1c reduction and greater increases in basal glucagon-like peptide-1 concentration...
March 21, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28295529/factors-determining-uptake-of-diabetic-retinopathy-screening-in-oxfordshire
#18
R B R Moreton, I M Stratton, S J Chave, H Lipinski, P H Scanlon
AIMS: To investigate variables at the demographic and primary care practice levels that influence the uptake of diabetic retinopathy screening. METHODS: Data were extracted from the management software of one screening programme for 21 797 people registered with 79 general practices. Uptake was examined by gender, age group, modality of screening (mobile unit at general practice versus high-street optometrist), and by general practice. A telephone survey of high-street optometrists provided information on the availability of screening appointments...
March 11, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28294392/cost-effectiveness-of-population-based-community-workplace-and-individual-policies-for-diabetes-prevention-in-the-uk
#19
P R Breeze, C Thomas, H Squires, A Brennan, C Greaves, P Diggle, E Brunner, A Tabak, L Preston, J Chilcott
AIM: To analyse the cost-effectiveness of different interventions for Type 2 diabetes prevention within a common framework. METHODS: A micro-simulation model was developed to evaluate the cost-effectiveness of a range of diabetes prevention interventions including: (1) soft drinks taxation; (2) retail policy in socially deprived areas; (3) workplace intervention; (4) community-based intervention; and (5) screening and intensive lifestyle intervention in individuals with high diabetes risk...
March 10, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28294386/integrated-primary-care-is-this-the-solution-to-the-diabetes-epidemic
#20
S Seidu, M J Davies, A Farooqi, K Khunti
The prevalence of Type 2 diabetes mellitus is rising exponentially across the globe [1], mainly as a result of changes in lifestyle [2]. Other factors accounting for this rise include proactive screening, people with diabetes living longer and an ageing general population [3]. With the increasing age comes an increase in the prevalence of chronic diseases and multimorbidity [4]. People with diabetes not only develop complications directly related to the condition, but also often have multimorbidities in addition to their diabetes [4]...
March 10, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
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