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Diabetic Medicine: a Journal of the British Diabetic Association

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https://www.readbyqxmd.com/read/30411402/evidence-based-diabetes-care-for-older-people-with-type-2-diabetes-a-critical-review
#1
A J Sinclair, A H Abdelhafiz, A Forbes, M Munshi
In our ageing society diabetes imposes a significant burden in terms of the numbers of people with the condition, diabetes-related complications including disability, and health and social care expenditure. Older people with diabetes can represent some of the more complex and difficult challenges facing the clinician working in different settings, and the recognition that we have only a relatively small (but increasing) evidence base to guide us in diabetes management is a limitation of our current approaches...
November 8, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30402933/prevalence-and-predictors-of-gestational-diabetes-mellitus-a-nationwide-multicentre-prospective-study
#2
H Aydın, Ö Çelik, D Yazıcı, Ç Altunok, Ö Tarçın, O Deyneli, S Sancak, S Kıyıcı, K Aydın, B Okan Yıldız
AIM: Prevalence rates of gestational diabetes mellitus (GDM) show considerable variation among different countries and regions of the world. The primary aim of this study was to determine the nationwide prevalence and predictors of GDM in Turkey. METHODS: We conducted prospective nationwide screening among pregnant women. Between August 2016 and November 2017, a total of 2643 pregnant women from 51 centres in 12 different regions were enrolled. A two-step screening method and Carpenter and Coustan criteria were used in the diagnosis of GDM...
November 7, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30402961/cardiovascular-disease-management-in-people-with-diabetes-outside-north-america-and-western-europe-in-2006-and-2015
#3
M Tabesh, D J Magliano, S K Tanamas, F Surmont, S Bahendeka, C-E Chiang, J F Elgart, J J Gagliardino, S Kalra, S Krishnamoorthy, A Luk, H Maegawa, A A Motala, F Pirie, A Ramachandran, K Tayeb, O Vikulova, J Wong, J E Shaw
AIM: Optimal treatment of cardiovascular disease is essential to decrease mortality among people with diabetes, but information is limited on how actual treatment relates to guidelines. We analysed changes in therapeutic approaches to anti-hypertensive and lipid-lowering medications in people with Type 2 diabetes from 2006 and 2015. METHODS: Summary data from clinical services in seven countries outside North America and Western Europe were collected for 39 684 people...
November 6, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30378713/changing-the-care-pathway-for-type-2-diabetes-at-the-time-of-diagnosis-the-role-of-the-multidisciplinary-team
#4
M B Whyte, N Munro
Conventionally, specialists become involved in the later stages of Type 2 diabetes mellitus, whereas evidence supports the role of time-limited specialist input at the start of treatment journey. The diagnosis of Type 2 diabetes should be seen as a key opportunity for multidisciplinary teams to intensify therapy aimed at quickly correcting underlying metabolic dysfunction. Insulin resistance can precede diabetes for a decade, during which time β-cell dysfunction and higher cardiovascular risk have accrued...
October 31, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30378706/can-type-2-diabetes-be-reversed-and-how-can-this-best-be-achieved-james-lind-alliance-research-priority-number-one
#5
R Taylor, A Barnes
The James Lind Alliance, in association with Diabetes UK, conducted a survey of people with Type 2 diabetes to establish their priorities for research. The number one research priority was found to be 'Can type 2 diabetes be cured or reversed, what is the best way to achieve this, and is there a point beyond which the condition cannot be reversed?'. The present review summarizes the current understanding of weight loss-induced reversal of type 2 diabetes. It considers the diagnostic criteria for remission and describes the clinical features of post-diabetes...
October 31, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30378166/written-communications-from-hospital-diabetes-departments-standards-required-to-mitigate-unintentional-harm
#6
L McMorrow, J Mullineaux, M Kendall, R Gregory
The importance of the words spoken by healthcare professionals when communicating to people with diabetes has been highlighted in the recent Position Statement of the English Advisory Group. The Working Group used a number of examples to illustrate both the potential positive and negative impact that language used by healthcare professionals can have on people with diabetes. The statement encouraged staff to be respectful, clear and understanding. The aim of this Letter is to use selected examples to raise awareness of the potential negative impact that written communications from hospital departments can have on people with diabetes, and to call for standards to be co-produced to drive improvements...
October 30, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30378165/a-systematic-review-of-observational-studies-of-the-association-between-pioglitazone-use-and-bladder-cancer
#7
E Ripamonti, L Azoulay, M Abrahamowicz, R W Platt, S Suissa
AIM: To conduct a systematic review of all observational studies on the effect of pioglitazone on the risk of bladder cancer. METHODS: The MEDLINE and EMBASE databases were queried for papers published between 1 January 2000 and 30 October 2017. We took into consideration observational studies (both retrospective and prospective) that included participants with Type 2 diabetes prescribed anti-hyperglycaemic drugs. RESULTS: While some studies reported an association, others did not, and meta-analyses of these studies showed a significantly increased risk; however, while meta-analysis is a powerful and practical statistical tool, its results should be considered with caution when applied to widely heterogeneous studies...
October 30, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30378161/recent-metformin-adherence-and-the-risk-of-hypoglycaemia-in-the-year-following-intensification-with-a-sulfonylurea
#8
J Y Min, M R Griffin, J Chipman, A J Hackstadt, R A Greevy, C G Grijalva, A M Hung, C L Roumie
AIM: To evaluate whether recent low adherence to metformin monotherapy is associated with hypoglycaemia after addition of a sulfonylurea. METHODS: We assembled a retrospective cohort of veterans who filled a new prescription for metformin between 2001 and 2011 and intensified treatment with a sulfonylurea after ≥1 year of metformin use. We calculated metformin adherence from pharmacy data using the proportion of days covered in the 180-day period before intensification...
October 30, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30368899/asymptomatic-hypoglycaemia-in-type-1-diabetes-incidence-and-risk-factors
#9
M M Henriksen, H U Andersen, B Thorsteinsson, U Pedersen-Bjergaard
AIM: The epidemiology of asymptomatic (silent) hypoglycaemia is not well-described. We investigated incidence and risk factors for asymptomatic hypoglycaemia in Type 1 diabetes. METHODS: A cohort of 153 people with Type 1 diabetes participated in 6 days of blinded continuous glucose monitoring (CGM) and recording of hypoglycaemia symptoms. At entry, hypoglycaemia awareness was classified (by three different methods) and HbA1c and C-peptide were measured. Hypoglycaemic episodes were defined as interstitial glucose ≤ 3...
October 27, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30368898/a-lifestyle-intervention-programme-for-the-prevention-of-type-2-diabetes-mellitus-among-south-asian-women-with-gestational-diabetes-mellitus-living-study-protocol-for-a-randomised-trial
#10
Yashdeep Gupta, Deksha Kapoor, Lakshmi K Josyula, Praveen Devarsetty, Aliya Naheed, Ankush K Desai, Arunasalam Pathmeswaran, Asita de Silva, Catherine B Lombard, Dewan Shamsul Alam, Prabhakaran Dorairaj, Helena J Teede, Laurent Billot, Neerja Bhatla, Rohina Joshi, Sophia Zoungas, Stephen Jan, Anushka Patel, Nikhil Tandon
AIM: The present study aims to determine whether a resource- and culturally-appropriate lifestyle intervention programme in South Asian countries, provided to women with GDM after childbirth, will reduce the incidence of worsening of glycaemic status in a manner that is affordable, acceptable, and scalable. METHODS: Women with GDM (diagnosed by oral glucose tolerance test [OGTT] using the IADPSG criteria) will be recruited from 16 hospitals in India, Sri Lanka, and Bangladesh...
October 27, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30362181/a-multicentre-uk-retrospective-observational-study-to-assess-the-effectiveness-of-insulin-glargine-300-units-ml-in-treating-people-with-type-1-diabetes-mellitus-in-routine-clinical-practice-sparta
#11
T Pang, S C Bain, R Neil A Black, J G Boyle, J Elliott, A Holcombe, K C S Lee, C Mulligan, L Saunders, A Yousseif, M Baxter
AIM: To conduct an open-label study to provide UK real-world evidence regarding the use of insulin glargine 300 units/ml (U300) in people with Type 1 diabetes mellitus. METHODS: People with Type 1 diabetes who had been prescribed U300 ≥6 months before data collection and had HbA1c levels recorded within 3 months prior to U300 (baseline) were included. The primary endpoint was change in HbA1c from baseline to month 6 after U300 initiation. Other endpoints included number of documented hypoglycaemic and ketoacidosis episodes, and change in daily basal insulin dose...
October 25, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30362180/the-ups-and-downs-of-low-carbohydrate-diets-in-the-management-of-type-1-diabetes-a-review-of-clinical-outcomes
#12
R Seckold, E Fisher, M deBock, B R King, C E Smart
Dietary management has been a mainstay of care in Type 1 diabetes since before the discovery of insulin when severe carbohydrate restriction was advocated. The use of insulin facilitated re-introduction of carbohydrate into the diet. Current management guidelines focus on a healthy and varied diet with consideration of glycaemic load, protein and fat. As a result of frustration with glycaemic outcomes, low-carbohydrate diets have seen a resurgence in popularity. To date, low-carbohydrate diets have not been well studied in the management of Type 1 diabetes...
October 25, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30362177/caudal-regression-syndrome-in-a-fetus-of-a-glucokinase-maturity-onset-diabetes-of-the-young-pregnancy
#13
R A M Taylor, A Mackie, R Mogra, J Pinner, S Rajendran, G P Ross
BACKGROUND: Glucokinase-maturity-onset diabetes of the young (GCK-MODY) is a form of diabetes caused by heterozygous inactivating mutations in the GCK gene. Affected individuals maintain their fasting glucose levels at a higher set point (5.4-8.3 mmol/l) than the general population. Hyperglycaemia in women with Type 1 or Type 2 diabetes is known to confer increased risk of fetal congenital abnormalities. The association between GCK-MODY and congenital abnormalities, however, remains uncertain...
October 25, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30362170/stem-cell-therapies-for-type-1-diabetes-current-status-and-proposed-road-map-to-guide-successful-clinical-trials
#14
P A Senior, J H Pettus
Many people with Type 1 diabetes struggle with the burden of self-management and are unable to achieve optimal glycaemic control without risk of hypoglycaemia. Future therapies with the potential to reduce the risk for short- and long-term complications while simultaneously reducing the burden of diabetes are therefore attractive. β-cell replacement is one strategy which might achieve this. Islet transplantation is limited by organ supply and the risks of long-term immunosuppression. Encapsulated stem-cell-derived β cells have the potential to address both of these issues and phase I/II clinical trials of encapsulated pancreatic progenitors have begun...
October 25, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30343524/pediatric-quality-of-life-inventory-pedsql-3-2-diabetes-module-for-youth-with-type-2-diabetes-reliability-and-validity
#15
J W Varni, A M Delamater, K K Hood, J K Raymond, N T Chang, K A Driscoll, J C Wong, J P Yi-Frazier, E K Grishman, M A Faith, S D Corathers, J C Kichler, J L Miller, E M Doskey, V P Aguirre, R W Heffer, D P Wilson
AIM: To test the measurement properties of the revised and updated Pediatric Quality of Life Inventory (PedsQL) 3.2 Diabetes Module originally developed in Type 1 diabetes in youth with Type 2 diabetes. METHODS: The PedsQL 3.2 Diabetes Module and PedsQL Generic Core Scales were administered in a field test study to 100 young people aged 9-25 years with Type 2 diabetes. Factor analysis was conducted to determine the factor structure of the items. RESULTS: The 15-item Diabetes Symptoms Summary Score and 12-item Type 2-specific Diabetes Management Summary Score were empirically derived through factor analysis...
October 21, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30343522/population-general-practitioner-and-practice-characteristics-are-associated-with-screening-procedures-for-microvascular-complications-in-type-2-diabetes-care-in-norway
#16
Å Bakke, A T Tran, I Dalen, J G Cooper, K F Løvaas, A K Jenum, T J Berg, T V Madsen, K Nøkleby, B Gjelsvik, T Claudi, S Skeie, S Carlsen, S Sandberg, G Thue
AIMS: To assess population, general practitioner (GP) and practice characteristics associated with the performance of microvascular screening procedures and to propose strategies to improve Type 2 diabetes care. METHODS: A cross-sectional survey in Norway (281 GPs from 77 practices) identified 8246 people with a Type 2 diabetes duration of 1 year or more. We used multilevel regression models with either the recording of at least two of three recommended screening procedures (albuminuria, monofilament, eye examination) or each procedure separately as dependent variable (yes/no), and characteristics related to the person with diabetes, GP or practice as independent variables...
October 21, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30343492/long-term-comparative-safety-analysis-of-the-risks-associated-with-adding-or-switching-to-a-sulfonylurea-as-second-line-type-2-diabetes-mellitus-treatment-in-a-us-veterans-affairs-population
#17
W R Powell, C L Christiansen, D R Miller
AIM: To examine the risks of all-cause mortality and cardiovascular events associated with adding vs switching to second-line therapies in a comparative safety study of people with Type 2 diabetes mellitus. METHODS: We conducted a retrospective cohort study using an as-treated analysis of people served by the Veterans Health Administration who were on metformin and subsequently augmented this treatment or switched to other oral glucose-lowering treatments between 1998 and 2012...
October 21, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30343489/automated-symptom-and-treatment-side-effect-monitoring-for-improved-quality-of-life-among-adults-with-diabetic-peripheral-neuropathy-in-primary-care-a-pragmatic-cluster-randomized-controlled-trial
#18
A S Adams, J A Schmittdiel, A Altschuler, E A Bayliss, R Neugebauer, L Ma, W Dyer, J Clark, B Cook, D Willyoung, M Jaffe, J D Young, E Kim, J M Boggs, L Prosser, E Wittenberg, B Callaghan, M Shainline, R M Hippler, R W Grant
AIMS: To evaluate the effectiveness of automated symptom and side effect monitoring on quality of life among individuals with symptomatic diabetic peripheral neuropathy. METHODS: We conducted a pragmatic, cluster randomized controlled trial (July 2014 to July 2016) within a large healthcare system. We randomized 1834 primary care physicians and prospectively recruited from their lists 1270 individuals with neuropathy who were newly prescribed medications for their symptoms...
October 21, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30329176/learning-about-type-1-diabetes-and-learning-to-live-with-it-when-diagnosed-in-adulthood-two-distinct-but-inter-related-psychological-processes-of-adaptation-a-qualitative-longitudinal-study
#19
M Due-Christensen, I Willaing, K Ismail, A Forbes
AIM: To explore the experiences of adults with newly diagnosed Type 1 diabetes in order to understand the adaptive processes that occur in the early phase of the condition. METHODS: We conducted longitudinal semi-structured interviews with 30 adults newly diagnosed with Type 1 diabetes (age range 20-67 years; 16 men; median diabetes duration 23.5 months), recruited from hospitals in Denmark and the UK. The data were analysed using a narrative approach. RESULTS: The narratives could be grouped into three thematic areas: the diagnosis; learning about diabetes; and learning to live with diabetes...
October 17, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30320946/developing-a-foot-ulcer-risk-model-what-is-needed-to-do-this-in-a-real-world-primary-care-setting
#20
A Heald, M Lunt, M K Rutter, S G Anderson, G Cortes, M Edmonds, E Jude, A Boulton, G Dunn
AIM: To determine how routinely collected data can inform a risk model to predict de novo foot ulcer presentation in the primary care setting. METHODS: Data were available on 15 727 individuals without foot ulcers and 1125 individuals with new foot ulcers over a 12-year follow-up in UK primary care. We examined known risk factors and added putative risk factors in our logistic model. RESULTS: People with foot ulcers were 4.2 years older (95% CI 3...
October 15, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
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