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Aquatic Toxicology

Ranran Zhou, Guanghua Lu, Zhenhua Yan, Runren Jiang, Jie Shen, Xuhui Bao
Ethylhexyl methoxy cinnamate (EHMC) is one of the major organic ultraviolet (UV) filter pollutants in the environment. The purpose of this study was to investigate the parental transfer of EHMC and induced biochemical responses in zebrafish (Danio rerio). Zebrafish embryos were exposed to EHMC solution (1, 10, and 100 μg/L) for 4 months until sexual maturation. Then male and female parents were paired to lay eggs. F1 generations were divided into 2 categories: with and without continued EHMC exposure...
November 3, 2018: Aquatic Toxicology
Zhenhua Yan, Hongwei Sun, Runren Jiang, Huike Dong, Haohan Yang, Jianchao Liu, Guanghua Lu, Yong Ji
Studies on the bioavailability of organic contaminants adsorbed to nanomaterials are increasing. In this study, we investigated the interaction between fluoxetine (FLX) and three multiwalled carbon nanotubes (MWCNTs) with different functional groups in zebrafish (Danio rerio) embryos, focusing on the FLX accumulation, the formation of the metabolite norfluoxetine (NFLX), and the active defence system responses. The accumulation of FLX in zebrafish was intensified by MWCNTs (46-99%), which simultaneously facilitated the formation of the metabolite NFLX by 23-167%...
October 30, 2018: Aquatic Toxicology
Chao Shen, Yixi Zhou, Jinpeng Ruan, Yung-Jen Chuang, Chonggang Wang, Zhenghong Zuo
Dioxin-like compounds (DLCs) are extremely stable toxic organic compounds and can cause serious health risks. To develop a convenient biomonitoring tool for the detection of DLCs in the environment, we generated a transgenic line-Tg(cyp1a-12DRE:EGFP)-with a zebrafish cyp1a promoter recombined with multiple dioxin-responsive elements (DREs) that drive EGFP expression. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced EGFP expression was observed in the head cartilage (most sensitive), gut, otic vesicle, pectoral fin bud and eye of larvae...
October 30, 2018: Aquatic Toxicology
Jeong Wan Do, Md Niamul Haque, Hyun-Jeong Lim, Byung Hwa Min, Do-Hee Lee, Jung-Hoon Kang, Moonkoo Kim, Jee-Hyun Jung, Jae-Sung Rhee
Sea-Nine (4,5-dichloro-2-n-octyl-4-isothiazoline3-one; DCOIT) antifoulant has been widely used owing to its broad spectrum of biocide activity against major fouling organisms. In this study, several physiological parameters of a marine mysid were analyzed upon exposure to sublethal environmental concentrations (1 and 100 ng L-1 ) of Sea-Nine in two exposure conditions, intermittent (weekly; once per week) and constant (daily; once per 24 h) exposure, for 4 weeks. In both experimental conditions, growth retardation, acetylcholinesterase (AChE) activity, glutathione S-transferase (GST) activity, and number of newborn juveniles as second generation, together with their survival were measured...
October 29, 2018: Aquatic Toxicology
Marlyete Chagas Araújo, Caio Rodrigo Dias Assis, Kaline Catiely Campos Silva, Kelma Sirleide Souza, Rafael Souto Azevedo, Maria Helena Menezes Estevam Alves, Luciano Clemente Silva, Valdir Luna Silva, Mônica Lúcia Adam, Luiz Bezerra Carvalho Junior, Ranilson Souza Bezerra, Maria Betânia Melo Oliveira
Acetylcholinesterase (AChE; EC is a serine hydrolase, whose main function is to modulate neurotransmission at cholinergic synapses. It is, therefore, the primary target of some pesticides and heavy metals. Its inhibition in aquatic organisms has been used as an indicator of the presence of these pollutants in water bodies. The present study aimed to characterize physicochemical and kinetic parameters of brain AChE in the benthic fish Hoplosternum littorale and to analyze the in vitro effects of pesticides (dichlorvos, diazinon, chlorpyrifos, parathion-methyl, temephos, carbaryl, carbofuran, aldicarb, diflubenzuron, novaluron and pyriproxyfen) and metal ions (As3+ , Cd2+ , Cu2+ , Fe2+ , Mn2+ , Mg2+ , K+ , Pb2+ , Hg2+ , Zn2+ ) investigating the potential of this enzyme as environmental biomarker based on current regulations...
October 26, 2018: Aquatic Toxicology
Jovica Lončar, Tvrtko Smital
Zebrafish Mate7 belongs to solute carrier protein superfamily and specifically to subfamily of multidrug and toxin extruders. It is co-orthologous to mammalian Mates, and is ubiquitously expressed in zebrafish tissues with the highest expression in kidney. It has been shown to interact with both endogenous (steroid hormones) and xenobiotic compounds (pharmaceuticals), implying a role in efflux of toxic compounds. The objective of our study was to analyse interaction of environmental contaminants with zebrafish Mate7 using a newly developed high throughput screening (HTS) Mate7 assay...
October 25, 2018: Aquatic Toxicology
Daniel F Frank, Susanne M Brander, Simone Hasenbein, Danielle J Harvey, Pamela J Lein, Juergen Geist, Richard E Connon
Altered transcription of calcium-dependent signaling cascades involving the ryanodine receptor (RyR) and mechanistic target of rapamycin (mTOR) in response to environmental exposures have been described in model vertebrates, including zebrafish, while the relevance for wild fishes remains unknown. To address this knowledge gap, we exposed the euryhaline model species Menidia beryllina (inland silversides) to the insecticide bifenthrin, a known modulator of calcium signaling. The main objectives of this study were to determine: (1) whether exposure of developing silversides to environmentally relevant concentrations of bifenthrin alters their behavior; and (2) whether behavioral changes correlate with altered expression of genes involved in RyR and mTOR-dependent signaling pathways...
October 24, 2018: Aquatic Toxicology
YanJun Zhang, RuiTao Zhang, HaoJie Sun, Qi Chen, XueDong Yu, Ting Zhang, Ming Yi, Jing-Xia Liu
The copper ion (Cu2+ ) has been reported to suppress the hatching of fish. However, little is known about the underlying mechanism. In this study, copper nanoparticles (CuNPs) and Cu2+ were shown to significantly suppress hatching of zebrafish in a dosage-dependent manner, and reactive oxygen species (ROS) scavengers NAC (N-acetylcysteine) & GSH (reduced glutathione) and Wnt signaling agonist BIO (6-bromoindirubin-3'-oxime) significantly alleviated the suppressing effects of Cu2+ and CuNPs on egg hatching...
October 24, 2018: Aquatic Toxicology
Maurizio Lazzari, Simone Bettini, Liliana Milani, Maria Gabriella Maurizii, Valeria Franceschini
The olfactory epithelium of fish includes three main types of olfactory sensory neurons (OSNs). Whereas ciliated (cOSNs) and microvillous olfactory sensory neurons (mOSNs) are common to all vertebrates, a third, smaller group, the crypt cells, is exclusive for fish. Dissolved pollutants reach OSNs, thus resulting in impairment of the olfactory function with possible neurobehavioral damages, and nickel represents a diffuse olfactory toxicant. We studied the effects of three sublethal Ni2+ concentrations on the different OSN populations of zebrafish that is a widely used biological model...
October 23, 2018: Aquatic Toxicology
Ágnes Vehovszky, Anna Farkas, Vivien Csikós, András Székács, Mária Mörtl, János Győri
Mussels are among the most frequently used invertebrate animals in aquatic toxicology to detect toxic exposure in the environment. The presence and activity of a cellular defence system, the multixenobiotic resistance (MXR) mechanism, was also established in these organisms. In isolated gill tissues of dreissenid mussels (D. bugensis) the MXR activity was assayed after treatment by commercially available insecticides (formulated products) which contain neonicotinoids as their active ingredients: Actara (thiamethoxam), Apacs (clothianidin), Calypso (thiacloprid) and Kohinor (imidacloprid), respectively...
October 23, 2018: Aquatic Toxicology
Silvana Manske Nunes, Marcelo Estrella Josende, Michael González-Durruthy, Caroline Pires Ruas, Marcos Alexandre Gelesky, Luis Alberto Romano, Daniele Fattorini, Francesco Regoli, José Maria Monserrat, Juliane Ventura-Lima
Although some studies have showed the effects of different crystalline structures of nTiO2 (anatase and rutile) and their applicability in several fields, few studies has analyzed the effect of coexposure with other environmental contaminants such as copper. Thus, the objective of this study was to evaluate if the coexposure to nTiO2 (nominal concentration of 1 mg/L; anatase or rutile) can increase the incorporation and toxic effect induced by Cu (nominal concentration of 56 μg/L) in different tissues of Linmoperna fortunei after 120 h of exposure...
October 22, 2018: Aquatic Toxicology
Ade Yamindago, Nayun Lee, Seonock Woo, Hyosun Choi, Ji Young Mun, Seok-Won Jang, Sung Ik Yang, Friederike Anton-Erxleben, Thomas C G Bosch, Seungshic Yum
Zinc oxide nanoparticles (ZnO NPs) are increasingly used in various products as coating and additive materials for household goods, personal-care products, and drug delivery systems. Because of their broad applications, the potential risks to nontarget organisms associated with their input into aquatic environments have generated much concern. We investigated the acute toxicity, morphological responses, and potential impact on physiology and metabolism in polyps exposed to spherical ZnO NPs of either 20 nm (ZnO NP20 ) or 100 nm (ZnO NP100 )...
October 21, 2018: Aquatic Toxicology
Gustavo Souza Santos, Giovano Neumann, Cristian Zwetzch do Nascimento, Cinthia Eloise Domingues, Sandro Xavier Campos, Robie Allan Bombardelli, Marta Margarete Cestari
The present work aimed to assess the genotoxic effects of intraperitoneally injected copper in males of O. niloticus, and to investigate its association with eventual changes in the quality of the gametes and in the generation of offspring abnormalities. Thus, to evaluate DNA damage, the alkaline comet assay was performed in sperm and blood; sperm parameters were analyzed to determine the quality of the gametes, and the incidence of morphological abnormalities of larvae, originated from eggs fertilized by males exposed to copper, was used as a measure of reproductive impairment...
October 21, 2018: Aquatic Toxicology
Lilah Glazer, Melissa C Kido Soule, Krista Longnecker, Elizabeth B Kujawinski, Neelakanteswar Aluru
Atlantic killifish inhabiting polluted sites along the east coast of the U.S. have evolved resistance to toxic effects of contaminants. One such contaminated site is the Acushnet River estuary, near New Bedford Harbor (NBH), Massachusetts, which is characterized by very high PCB concentrations in the sediments and in the tissues of resident killifish. Though killifish at this site appear to be thriving, the metabolic costs of survival in a highly contaminated environment are not well understood. In this study we compared the hepatic metabolite profiles of resistant (NBH) and sensitive populations (Scorton Creek (SC), Sandwich, MA) using a targeted metabolomics approach in which polar metabolites were extracted from adult fish livers and quantified...
October 16, 2018: Aquatic Toxicology
Mélodie Schmitz, Mahaut Beghin, Syaghalirwa N M Mandiki, Katherine Nott, Michaël Gillet, Sébastien Ronkart, Christelle Robert, Sébastien Baekelandt, Patrick Kestemont
Because of their intrinsic biological activity and ubiquitous environmental occurrence, human pharmaceutical compounds have received increasing attention from health and environmental agencies. In the present study, all-female juvenile rainbow trout (Oncorhynchus mykiss) were exposed to environmentally-realistic concentrations of a mixture of nonsteroidal pharmaceuticals for 42 days, and the effects on plasma levels of sex-steroids and the expression of genes encoding key proteins involved in ovarian development were assessed...
October 13, 2018: Aquatic Toxicology
Ricardo Fernández-Cisnal, Miguel A García-Sevillano, Tamara García-Barrera, José L Gómez-Ariza, Nieves Abril
Soils contaminated by toxic metallic elements from agricultural activities raise grave concern about their potential risk to human health through direct intake, bioaccumulation through the food chain, and their impacts on ecological systems. We have measured here the lipid and protein oxidation status and used metabolomic methodologies to identify and characterize the changes caused by metal pollution exposure in the digestive glands and gills of Procambarus clarkii, the red swamp crayfish. Specimens captured at two sites with intensive agriculture practices using diverse types of agrochemicals, located in the borders of Doñana Natural Park, were compared to ones caught in the core of the Park, a proven non-polluted place...
October 13, 2018: Aquatic Toxicology
Xiao-Xiong Wang, Tian-Yuan Zhang, Guo-Hua Dao, Hong-Ying Hu
Isothiazolinones, such as 1,2-benzisothiazol-3(2H)-one (BIT), are widely used as biocides for bacterial growth control in many domestic and industrial processes. Despite their advantages as biocides, they are highly toxic and pose a potential risk to the environment. This study investigated the inhibition process and detoxification mechanism involved in microalgal survival and growth recovery after BIT poisoning. BIT could seriously inhibit the growth of Scenedesmus sp. LX1, Chlorella sp. HQ, and Chlamydomonas reinhardtii with half maximal effective concentrations at 72 h (72h-EC50 ) of 1...
October 10, 2018: Aquatic Toxicology
Erin Ussery, Kristin N Bridges, Zacharias Pandelides, Andrea E Kirkwood, Dario Bonetta, Barney J Venables, John Guchardi, Douglas Holdway
Metformin is one of the most prevalent pharmaceuticals in both surface and waste waters, yet little is known about the bioavailability and/or effects of developmental exposure on early life stage (ELS) fish. Here, we demonstrate that embryo-larval stages of medaka are capable of taking up metformin from the aquatic environment, provided exposure occurs prior to chorion hardening (∼6-hpf). Once transferred to clean water, ELS medaka are able to completely depurate metformin in <24-hours. Furthermore, ELS medaka exposed to a range of relevant concentrations of waterborne metformin (from 6 hpf through 28-days post hatch) had significantly reduced growth metrics, altered metabolomes, and changes in the expression of genes associated with cell growth...
October 9, 2018: Aquatic Toxicology
Qiaona Xue, Rui Wang, Wenjing Xu, Jiangtao Wang, Liju Tan
The allelopathic effects of extracts isolated from the culture filtrate of diatom Phaeodactylum triconutum Bohlin on typical marine microalgae Prorocentrum donghaiense Lu and Dunaliella salina Teodoresco were investigated by determining different physiological and biochemical parameters, such as growth rate, membrane systems and esterase activity under controlled laboratory conditions. The growth of P. donghaiense was significantly inhibited immediately after exposure to the allelochemicals, while the algae density of D...
October 9, 2018: Aquatic Toxicology
Palas Samanta, Sandipan Pal, Tarakeshwar Senapati, Aloke Kumar Mukherjee, Apurba Ratan Ghosh
Present study was designed to evaluate the adverse effect of glyphosate-based herbicide, Excel Mera 71 in Anabas testudineus on comparative basis under field and laboratory conditions. Field (750 g/acre) and laboratory (17.2 mg/L) experiments were performed for a period of 30 days. For field experiment special type of cages were prepared. Fish gill, liver, and kidney were analyzed for histology and ultrastructural responses. A significant increment in morphometric indices (DTC) was observed in gill, liver and kidney of A...
October 3, 2018: Aquatic Toxicology
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