journal
MENU ▼
Read by QxMD icon Read
search

Virus Research

journal
https://www.readbyqxmd.com/read/28916365/sodium-phenylbutyrate-abrogates-african-swine-fever-virus-replication-by-disrupting-the-virus-induced-hypoacetylation-status-of-histone-h3k9-k14
#1
Gonçalo Frouco, Ferdinando B Freitas, Carlos Martins, Fernando Ferreira
African swine fever virus (ASFV) causes a highly lethal disease in swine for which neither a vaccine nor treatment are available. Recently, a new class of drugs that inhibit histone deacetylases enzymes (HDACs) has received an increasing interest as antiviral agents. Considering studies by others showing that valproic acid, an HDAC inhibitor (HDACi), blocks the replication of enveloped viruses and that ASFV regulates the epigenetic status of the host cell by promoting heterochromatinization and recruitment of class I HDACs to viral cytoplasmic factories, the antiviral activity of four HDACi against ASFV was evaluated in this study...
September 12, 2017: Virus Research
https://www.readbyqxmd.com/read/28912070/recombinant-influenza-h7-hemagglutinin-containing-cfllc-minidomain-in-the-transmembrane-domain-showed-enhanced-cross-protection-in-mice
#2
Yang Wang, Yun Zhang, Jialing Wu, Ying Lin, Zhihui Wu, Ying Wei, Xiaona Wei, Jianru Qin, Chunyi Xue, George Dacai Liu, Yongchang Cao
Since February 2013, H7N9 influenza virus, causing human infections with high mortality in China, has been a potential pandemic threat. The H7N9 viruses are found to diverge into distinct genotypes as other influenza viruses; thus a vaccine that can provide sufficient cross-protection against different genotypes of H7N9 viruses is urgently needed. Our previous studies demonstrated that the HA-based structural design approach by introducing a CFLLC minidomain into transmembrane domain (TM) of H1, H5 or H9 hemagglutinin (HA) proteins by replacing with H3 subtype HA TM could enhance their cross-protection...
September 11, 2017: Virus Research
https://www.readbyqxmd.com/read/28912069/generation-of-a-novel-human-cytomegalovirus-bacterial-artificial-chromosome-tailored-for-transduction-of-exogenous-sequences
#3
William L Close, Amit Bhandari, Marwa Hojeij, Philip E Pellett
The study of herpesviruses, including human cytomegalovirus (HCMV), is complicated by viral genome complexity and inefficient methods for genetic manipulation in tissue culture. Reverse genetics of herpesviruses has been facilitated by propagating their genomes in E. coli as bacterial artificial chromosomes (BACs), which enables complex and precise genetic manipulation using bacterial recombinational systems. Internal capsid volume imposes a strict limit on the length of genome that can be packaged efficiently...
September 11, 2017: Virus Research
https://www.readbyqxmd.com/read/28899653/role-of-autophagy-in-zika-virus-infection-and-pathogenesis
#4
REVIEW
Abhilash I Chiramel, Sonja M Best
Autophagy is an evolutionarily conserved cellular pathway that culminates in lysosomal degradation of selected substrates. Autophagy can serve dual roles in virus infection with either pro- or antiviral functions depending on the virus and the stage of the viral replication cycle. Recent studies have suggested a role for autophagy in Zika virus (ZIKV) replication by demonstrating the accumulation of autophagic vesicles following ZIKV infection in both in vitro and in vivo models. In human fetal neural stem cells, ZIKV inhibits Akt-mTOR signaling to induce autophagy, increase virus replication and impede neurogenesis...
September 9, 2017: Virus Research
https://www.readbyqxmd.com/read/28893653/hepatitis-c-virus-induced-innate-immune-responses-in-human-ips-cell-derived-hepatocyte-like-cells
#5
Fuminori Sakurai, Takemaru Kunito, Kazuo Takayama, Rina Hashimoto, Masashi Tachibana, Naoya Sakamoto, Takaji Wakita, Hiroyuki Mizuguchi
Hepatitis C virus (HCV) infection is a major cause of liver-related morbidity and mortality. In order to develop effective remedies for hepatitis C, it is important to understand the HCV infection profile and host-HCV interaction. HCV-induced innate immune responses play a crucial role in spontaneous HCV clearance; however, HCV-induced innate immune responses have not been fully evaluated in hepatocytes, partly because there are few in vitro models of HCV-induced innate immunity. Recently, human induced pluripotent stem (iPS) cells have received much attention as an in vitro model of infection with various pathogens, including HCV...
September 9, 2017: Virus Research
https://www.readbyqxmd.com/read/28893654/strain-specific-association-of-soybean-dwarf-virus-small-subgenomic-rna-with-virus-particles
#6
Thanuja Thekke-Veetil, Nancy K McCoppin, Leslie L Domier
Soybean dwarf virus (SbDV) produces a large subgenomic RNA (LsgRNA) for expression of structural and movement proteins and a small subgenomic RNA (SsgRNA) that does not contain an open reading frame. Sucrose gradient-purified SbDV virions from soybean plants systemically infected with SbDV by aphids and Nicotiana benthamiana leaves agroinfiltrated with infectious clones of two red clover SbDV isolates encapsidated genomic RNA and were associated with SsgRNA in a strain-specific manner. The LsgRNA was protected from RNase degradation, but not packaged into virions as indicated by its presence primarily in ELISA-negative fractions near the tops of sucrose gradients even in mutants that did not express coat protein...
September 8, 2017: Virus Research
https://www.readbyqxmd.com/read/28893652/a-new-threat-to-human-reproduction-system-posed-by-zika-virus-zikv-from-clinical-investigations-to-experimental-studies
#7
REVIEW
Xiangdong Li, Wenqiang Ma, Gary Wong, Shuoqian Ma, Shihua Li, Yuhai Bi, George F Gao
Zika virus (ZIKV) was first isolated in 1947 from a rhesus monkey in the Zika forest of Uganda. ZIKV has since been silently circulating in a number of equatorial countries for over 50 years. The largest outbreak in humans occurred in Brazil in 2015-2016. Unlike its flavivirus relatives, sexual and post-transfusion transmissions of ZIKV have been reported. In addition, fetal infection can result in microcephaly and congenital Zikv syndrome has been reported in neonates. Moreover, ZIKV RNA can persist for at least 6 months in semen and 11 weeks in vaginal secretions after the infection, suggesting potential tropism for the male and female genital tracts...
September 8, 2017: Virus Research
https://www.readbyqxmd.com/read/28870470/poliovirus-receptor-more-than-a-simple-viral-receptor
#8
REVIEW
Jonathan R Bowers, James M Readler, Priyanka Sharma, Katherine J D A Excoffon
The human poliovirus receptor (PVR) is a cell surface protein with a multitude of functions in human biology. PVR was initially identified as the receptor for the human poliovirus and recent discoveries have given a greater insight into both its morphology and its function. Alternative splicing of the PVR gene results in a total of 4 alternatively spliced isoforms. Two of these isoforms lack a complete transmembrane domain and are considered soluble and block viral infection; the remaining two transmembrane isoforms differ only at their extreme C-terminal domains resulting in differential localization in epithelia and polarity of viral infection...
September 7, 2017: Virus Research
https://www.readbyqxmd.com/read/28870469/first-demonstration-of-equid-gammaherpesviruses-within-the-gastric-mucosal-epithelium-of-horses
#9
Matthew R Pennington, Brieuc G A Cossic, Gillian A Perkins, Carol Duffy, Gerald E Duhamel, Gerlinde R Van de Walle
Horses commonly develop gastric mucosal ulcers, similar to humans, a condition known as equine gastric ulcer syndrome (EGUS) that can lead to poor performance and lost training time and care expenses. Unlike humans, however, an infectious bacterial cause of ulcers has not been conclusively identified. Herpesviruses, while well-established causative agents of diseases such as cold sores, genital lesions, and certain types of cancer, have also been implicated in the development of a subset of gastric ulcers in humans...
September 16, 2017: Virus Research
https://www.readbyqxmd.com/read/28867494/targeting-human-breast-cancer-cells-by-an-oncolytic-adenovirus-using-microrna-targeting-strategy
#10
Mohammad Shayestehpour, Sharareh Moghim, Vahid Salimi, Somayeh Jalilvand, Jila Yavarian, Bizhan Romani, Talat Mokhtari-Azad
MicroRNA-targeting strategy is a promising approach that enables oncolytic viruses to replicate in tumor cells but not in normal cells. In this study, we targeted adenoviral replication toward breast cancer cells by inserting ten complementary binding sites for miR-145-5p downstream of E1A gene. In addition, we evaluated the effect of increasing miR-145 binding sites on inhibition of virus replication. Ad5-control and adenoviruses carrying five or ten copies of miR145-5p target sites (Ad5-5miR145T, Ad5-10miR145T) were generated and inoculated into MDA-MB-453, BT-20, MCF-7 breast cancer cell lines and human mammary epithelial cells (HMEpC)...
September 1, 2017: Virus Research
https://www.readbyqxmd.com/read/28867492/7th-european-rotavirus-biology-conference-cork-ireland-18-21-june-2017
#11
Ulrich Desselberger
No abstract text is available yet for this article.
September 1, 2017: Virus Research
https://www.readbyqxmd.com/read/28867493/taking-the-defensive-immune-control-of-zika-virus-infection
#12
REVIEW
James R Bowen, Matthew G Zimmerman, Mehul S Suthar
ZIKV is a neurotropic mosquito-borne flavivirus that has recently emerged in the Americas and is a pathogen of significant public health concern across the world. ZIKV was first isolated in Uganda in 1947 and remained dormant in Africa and Asia for decades, with sporadic outbreaks characterized by a mild self-limiting disease in humans. The emergence of ZIKV in the Americas corresponded with enhanced disease severity and congenital Zika syndrome, a phenotype characterized by severe microcephaly, brain anomalies, ocular anomalies, congenital contractures and neurological impairments...
September 1, 2017: Virus Research
https://www.readbyqxmd.com/read/28864425/functional-rna-during-zika-virus-infection
#13
REVIEW
Giel P Göertz, Sandra R Abbo, Jelke J Fros, Gorben P Pijlman
Zika virus (ZIKV; family Flaviviridae; genus Flavivirus) is a pathogenic mosquito-borne RNA virus that currently threatens human health in the Americas, large parts of Asia and occasionally elsewhere in the world. ZIKV infection is often asymptomatic but can cause severe symptoms including congenital microcephaly and Guillain-Barré syndrome. The positive single-stranded RNA genome of the mosquito-borne ZIKV requires effective replication in two evolutionary distinct hosts - mosquitoes and primates. In addition to some of the viral proteins, the ZIKV genomic RNA and functional RNAs produced thereof aid in the establishment of productive infection and the evasion of host cell antiviral responses...
August 31, 2017: Virus Research
https://www.readbyqxmd.com/read/28864423/alpha-mangostin-inhibits-both-dengue-virus-production-and-cytokine-chemokine-expression
#14
Mayuri Tarasuk, Pucharee Songprakhon, Pattamawan Chimma, Panudda Sratongno, Kesara Na-Bangchang, Pa-Thai Yenchitsomanus
Since severe dengue virus (DENV) infection in humans associates with both high viral load and massive cytokine production - referred to as "cytokine storm", an ideal drug for treatment of DENV infection should efficiently inhibit both virus production and cytokine expression. In searching for such an ideal drug, we discovered that α-mangostin (α-MG), a major bioactive compound purified from the pericarp of the mangosteen fruit (Garcinia mangostana Linn), which has been used in traditional medicine for several conditions including trauma, diarrhea, wound infection, pain, fever, and convulsion, inhibits both DENV production in cultured hepatocellular carcinoma HepG2 and Huh-7 cells, and cytokine/chemokine expression in HepG2 cells...
August 31, 2017: Virus Research
https://www.readbyqxmd.com/read/28860099/analysis-of-stress-factors-associated-with-khv-reactivation-and-pathological-effects-from-khv-reactivation
#15
Lisa Lin, Sammi Chen, Duncan S Russell, Christiane V Löhr, Ruth Milston-Clements, Tiffany Song, Tim Miller-Morgan, Ling Jin
Koi herpesvirus (KHV) is a highly pathogenic virus of common carp and koi. KHV becomes latent in recovered koi or exposed koi without symptoms, and the latent infection can reactivate under stress conditions. KHV reactivation from latency often occurs when water temperature rapidly rises above 17°C. Dissolved O2 is lower at ≥17°C than at non-stress temperatures ≤15°C. To determine whether reduced dissolved O2 level has a role in KHV reactivation during temperature stress, KHV reactivation was investigated in KHV latently infected koi (KHV(+) koi) under stress temperatures by maintaining dissolved O2 consistent with the O2 level at 15°C...
August 30, 2017: Virus Research
https://www.readbyqxmd.com/read/28860098/monocyte-chemoattractant-protein-1-released-from-macrophages-induced-by-hepatitis-c-virus-promotes-monocytes-migration
#16
Yuan Liu, Wenbo Wang, Ziying Zou, Quanshui Fan, Zonghai Hu, Ziliang Feng, Bing Zhu, Jie Xiong
Hepatitis C Virus (HCV) infection usually progress to chronic liver disease and shows a significant increase in total monocyte/macrophages numbers in the liver. Monocyte chemoattractant protein-1 (MCP-1) plays a role in the recruitment of monocytes to the liver. In this study we found that MCP-1 were up-regulated in macrophages cultured with cell-culture derived infectious HCV particles (HCVcc) and promoted the migration of monocytes. IL1β, IL6 and TNFα were factors that induced MCP-1 expression, which were up-regulated in macrophages induced by HCV...
August 30, 2017: Virus Research
https://www.readbyqxmd.com/read/28864424/wheat-streak-mosaic-virus-coat-protein-is-a-host-specific-long-distance-transport-determinant-in-oats
#17
Satyanarayana Tatineni
Viral determinants involved in systemic infection of hosts by monocot-infecting plant viruses are poorly understood. Wheat streak mosaic virus (WSMV, genus Tritimovirus, family Potyviridae) exclusively infects monocotyledonous crops such as wheat, oat, barley, maize, triticale, and rye. Previously, we reported that WSMV CP amino acids 36 to 84 are expendable for systemic infection of wheat, maize, barley and rye. In this study, the role of coat protein (CP) in systemic infection of oat by WSMV was examined by using a series of viable deletion mutants...
August 29, 2017: Virus Research
https://www.readbyqxmd.com/read/28855097/genomes-of-viral-isolates-derived-from-different-mosquitos-species
#18
Mohammadreza Sadeghi, Vsevolod Popov, Hilda Guzman, Tung Gia Phan, Nikos Vasilakis, Robert Tesh, Eric Delwart
Eleven viral isolates derived mostly in Aedes cells from mosquito pools collected in Southeast Asia and the Americas between 1966 and 2014 contained particles with electron microscopy morphology typical of reoviruses. Metagenomics analysis yielded the near complete genomes of three novel reoviruses, Big Cypress orbivirus, Ninarumi virus, and High Island virus and a new tetravirus, Sarawak virus. Strains of previously characterized Sathuvarachi, Yunnan, Banna and Parry's Lagoon viruses (Reoviridae), Bontang virus (Mesoniviridae), and Culex theileri flavivirus (Flaviviridae) were also characterized...
August 27, 2017: Virus Research
https://www.readbyqxmd.com/read/28847699/molecular-characterization-of-canine-parvovirus-and-canine-enteric-coronavirus-in-diarrheic-dogs-on-the-island-of-st-kitts-first-report-from-the-caribbean-region
#19
Ryan Navarro, Rajeev Nair, Andrea Peda, Meiji Soe Aung, G S Ashwinie, Christa A Gallagher, Yashpal S Malik, Nobumichi Kobayashi, Souvik Ghosh
Although canine parvovirus (CPV) and canine enteric coronavirus (CCoV) are important enteric pathogens of dogs and have been studied extensively in different parts of the world, there are no reports on these viruses from the Caribbean region. During 2015-2016, a total of 104 diarrheic fecal samples were collected from puppies and adult dogs, with or without hemorrhagic gastroenteritis, on the Caribbean island of St. Kitts (KNA). By PCR, 25 (24%, n=104) samples tested positive for CPV. Based on analysis of the complete deduced VP2 amino acid sequences, 20 of the KNA CPV strains were assigned to new CPV-2a (also designated as CPV-2a-297A)...
August 26, 2017: Virus Research
https://www.readbyqxmd.com/read/28837817/polymorphisms-associated-with-resistance-to-protease-inhibitors-in-na%C3%A3-ve-patients-infected-with-hepatitis-c-virus-genotype-1-in-argentina-low-prevalence-of-q80k
#20
Alfredo P Martínez, Andrés C A Culasso, Paula S Pérez, Vanesa Romano, Rodolfo H Campos, Ezequiel Ridruejo, Gabriel García, Federico A Di Lello
Incorporation of direct acting antivirals (DAA) in the treatment of Hepatitis C Virus (HCV) significantly increases sustained virologic response rates. However, despite the greater potency offered by these antivirals, drug resistance plays a key role in patients with failure to DAA. Nevertheless, there is no information about the prevalence of resistance-associated substitutions (RASs) in Argentina. The aim of this study was to analyze HCV variants resistant to protease inhibitors (PI) in naïve patients infected with HCV genotype 1 from Argentina...
August 26, 2017: Virus Research
journal
journal
28879
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"