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Clinical & Experimental Metastasis

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https://www.readbyqxmd.com/read/28317069/deciphering-the-role-of-ectosomes-in-cancer-development-and-progression-focus-on-the-proteome
#1
REVIEW
Magdalena Surman, Ewa Stępień, Dorota Hoja-Łukowicz, Małgorzata Przybyło
Ectosomes are small heterogeneous membrane vesicles generated by budding from the plasma membrane in a variety of cell types and, more frequently, in tumor cells. They are shed into the extracellular space and are proposed as a novel form of intracellular communication in which information is transmitted from the originating cell to recipient cells without direct cell-to-cell contact. This review focuses on a single population of extracellular vesicles-ectosomes. We summarize recent studies of tumor-derived ectosomes which examine their biogenesis and protein cargo, and their influence on different aspects of cancer progression...
March 19, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28289921/genome-wide-in-vivo-rnai-screen-identifies-itih5-as-a-metastasis-suppressor-in-pancreatic-cancer
#2
Ken Sasaki, Hiroshi Kurahara, Eric D Young, Shoji Natsugoe, Asami Ijichi, Tomoo Iwakuma, Danny R Welch
The overwhelming majority of pancreatic ductal adenocarcinoma (PDAC) is not diagnosed until the cancer has metastasized, leading to an abysmal average life expectancy (3-6 months post-diagnosis). Earlier detection and more effective treatments have been hampered by inadequate understanding of the underlying molecular mechanisms controlling metastasis. We hypothesized that metastasis suppressors are involved in controlling metastasis in pancreatic cancer. Using an unbiased genome-wide shRNA screen, an shRNA library was transduced into the non-metastatic PDAC line S2-028 followed by intrasplenic injection...
March 13, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28260197/meeting-report-metastasis-research-society-chinese-tumor-metastasis-society-joint-conference-on-metastasis
#3
Katherine Bankaitis, Lucia Borriello, Thomas Cox, Conor Lynch, Andries Zijlstra, Barbara Fingleton, Miodrag Gužvić, Robin Anderson, Josh Neman
During September 16th-20th 2016, metastasis experts from around the world convened for the 16th Biennial Congress of the Metastasis Research Society and 12th National Congress of the Chinese Tumor Metastasis Society in Chengdu, China to share most current data covering basic, translational, and clinical metastasis research. Presentations of the more than 40 invited speakers of the main congress and presentations from the associated Young Investigator Satellite Meeting are summarized in this report by session topic...
March 4, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28260196/a-reflection-and-a-look-forward-with-dr-sue-eccles-retired-editor-in-chief-of-clinical-and-experimental-metastasis
#4
Katherine V Bankaitis
After a lifetime's work devoted to metastasis research, Dr. Sue Eccles recently retired. She was a founding member the Metastasis Research Society in 1984, and has served as Editor-In-Chief of Clinical and Experimental Metastasis from its inception until her retirement, an amazing 32 years of service. Dr. Kate Bakaitis recently talked with Dr. Eccles about her experiences, memories and advice for young investigators.
March 4, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28210910/astrocyte-induced-reelin-expression-drives-proliferation-of-her2-breast-cancer-metastases
#5
Rahul Jandial, Cecilia Choy, Danielle M Levy, Mike Y Chen, Khairul I Ansari
Breast cancer metastasis to the brain develops after a clinical latency of years to even decades, suggesting that colonization of the brain is the most challenging step of the metastatic cascade. However, the underlying mechanisms used by breast cancer cells to successfully colonize the brain's microenvironment remain elusive. Reelin is an archetypal extracellular glycoprotein that regulates migration, proliferation, and lamination of neurons. It is epigenetically silenced in various cancers, and its expression in multiple myelomas is linked to poor patient survival...
February 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28168393/enhanced-colorectal-cancer-metastases-in-the-alcohol-injured-liver
#6
Ashley M Mohr, John J Gould, Jacy L Kubik, Geoffrey A Talmon, Carol A Casey, Peter Thomas, Dean J Tuma, Benita L McVicker
Metastatic liver disease is a major cause of mortality in colorectal cancer (CRC) patients. Alcohol consumption is a noted risk factor for secondary cancers yet the role of alcoholic liver disease (ALD) in colorectal liver metastases (CRLM) is not defined. This work evaluated tumor cell colonization in the alcoholic host liver using a novel preclinical model of human CRC liver metastases. Immunocompromised Rag1-deficient mice were fed either ethanol (E) or isocaloric control (C) diets for 4 weeks prior to intrasplenic injection of LS174T human CRC cells...
February 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28160109/antimetastatic-pectic-polysaccharide-from-decalepis-hamiltonii-galectin-3-inhibition-and-immune-modulation
#7
Sathisha U Venkateshaiah, Mallikarjuna S Eswaraiah, Harish Nayaka M Annaiah, Shylaja M Dharmesh
Melanoma is a malignant neoplasm of major concern because of its high mortality rate and failure of chemotherapy. Previously we have shown that galectin-3, a galactose specific lectin, plays a pivotal role in the initiation of metastasis. It was hypothesized that blocking galectin-3 with galactose rich dietary pectic polymer would inhibit metastasis. The current study analyzes the preventive effect and mode of action of a pectic polymer from Swallow Root (Decalepis hamiltonii) in a preventative study of B16F10 cells lung colonization...
February 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28124276/activated-thrombin-activatable-fibrinolysis-inhibitor-attenuates-the-angiogenic-potential-of-endothelial-cells-potential-relevance-to-the-breast-tumour-microenvironment
#8
Zainab A Bazzi, Jennifer Balun, Dora Cavallo-Medved, Lisa A Porter, Michael B Boffa
Thrombin-activatable fibrinolysis inhibitor (TAFI) is a basic carboxypeptidase zymogen present in blood plasma. Proteolytic activation of TAFI by thrombin, thrombin in complex with the endothelial cell cofactor thrombomodulin, or plasmin results in an enzyme (TAFIa) that removes carboxyl-terminal lysine residues from protein and peptide substrates, including cell-surface plasminogen receptors. TAFIa is therefore capable of inhibiting plasminogen activation in the pericellular milieu. Since plasminogen activation has been linked to angiogenesis, TAFIa could therefore have anti-angiogenic properties, and indeed TAFIa has been shown to inhibit endothelial tube formation in a fibrin matrix...
February 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28108861/in-vivo-magnetic-resonance-imaging-investigating-the-development-of-experimental-brain-metastases-due-to-triple-negative-breast-cancer
#9
Amanda M Hamilton, Paula J Foster
Triple negative breast cancer (TNBC), when associated with poor outcome, is aggressive in nature with a high incidence of brain metastasis and the shortest median overall patient survival after brain metastasis development compared to all other breast cancer subtypes. As therapies that control primary cancer and extracranial metastatic sites improve, the incidence of brain metastases is increasing and the management of patients with breast cancer brain metastases continues to be a significant clinical challenge...
February 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28101700/predicting-brain-metastases-for-non-small-cell-lung-cancer-based-on-magnetic-resonance-imaging
#10
Gang Yin, Churong Li, Heng Chen, Yangkun Luo, Lucia Clara Orlandini, Pei Wang, Jinyi Lang
In this study the relationship between brain structure and brain metastases (BM) occurrence was analyzed. A model for predicting the time of BM onset in patients with non-small cell lung cancer (NSCLC) was proposed. Twenty patients were used to develop the model, whereas the remaining 69 were used for independent validation and verification of the model. Magnetic resonance images were segmented into cerebrospinal fluid, gray matter (GM), and white matter using voxel-based morphometry. Automatic anatomic labeling template was used to extract 116 brain regions from the GM volume...
February 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28062976/the-predictive-accuracy-of-sentinel-nodes-mapping-in-the-setting-of-pulmonary-metastasectomy
#11
Hyun Koo Kim, Kwanghyoung Lee, Kook Nam Han, Jae Seon Eo, Sungeun Kim, Young Ho Choi
This is the first study to evaluate the feasibility of mediastinal lymph node dissection (MLND) based on sentinel lymph node (SLN) status during pulmonary metastasectomy. A total of 22 patients (16 men, 6 women; age 63.3 ± 7.01 years) who were candidates for metastasectomy through segmentectomy or lobectomy with MLND owing to cancers metastatic to the lung were enrolled in this study. Radiotracer was administered at the peritumoral region before surgery or soon after initiating surgery. During the operation, the radioactivity of the lymph nodes (ex vivo) was counted with a handheld gamma probe after MLND...
February 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27999982/the-prognostic-effect-of-ddx3-upregulation-in-distant-breast-cancer-metastases
#12
Marise R Heerma van Voss, Willemijne A M E Schrijver, Natalie D Ter Hoeve, Laurien D Hoefnagel, Quirine F Manson, Elsken van der Wall, Venu Raman, Paul J van Diest
Metastatic breast cancer remains one of the leading causes of death in women and identification of novel treatment targets is therefore warranted. Functional studies showed that the RNA helicase DDX3 promotes metastasis, but DDX3 expression was never studied in patient samples of metastatic cancer. In order to validate previous functional studies and to evaluate DDX3 as a potential therapeutic target, we investigated DDX3 expression in paired samples of primary and metastatic breast cancer. Samples from 79 breast cancer patients with distant metastases at various anatomical sites were immunohistochemically stained for DDX3...
January 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27988895/radiopharmaceuticals-for-metastatic-bone-pain-palliation-available-options-in-the-clinical-domain-and-their-comparisons
#13
REVIEW
Tapas Das, Sharmila Banerjee
Bone pain arising due to skeletal metastases is one of the common complications experienced by the majority of patients suffering from prostate, breast and lung cancer at the advanced stage of the disease. These patients are subjected to palliative care in order to improve the quality of their remaining life. With the gradually increasing number of cancer cases, palliation of metastatic bone pain is gaining importance. Bone-seeking radiopharmaceuticals play a pivotal role in the management of cancer pain, particularly in patients with multiple metastases, as these agents are proven to be effective in controlling the bone pain with minimum side effects...
January 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27888377/correlation-between-status-of-epidermal-growth-factor-receptor-mutation-and-distant-metastases-of-lung-adenocarcinoma-upon-initial-diagnosis-based-on-1063-patients-in-china
#14
Hongwei Li, Jianzhong Cao, Xiaqin Zhang, Xing Song, Weili Wang, Sufang Jia, Zhengran Li, Haixia Jia, Xing Cao, Wei Zhou, Jianhong Lian, Songye Han, Weihua Yang, Yanfen Xi, Shenming Lian, Haoxing Jing
The study aimed to explore the correlations between status of epidermal growth factor receptor (EGFR) mutations and distant metastases. A total of 1063 patients with lung adenocarcinoma indentified with status of EGFR mutations from August 2010 to May 2015 at Shanxi Cancer Hospital were enrolled. 456 patients were confirmed with EGFR mutations. The associations among EGFR mutations, clinical factors, and distant metastases at initial diagnosis were evaluated. Patients harboring EGFR mutation were more likely to be female (P < 0...
January 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27885435/comparison-of-immunophenotypes-of-primary-breast-carcinomas-and-multiple-corresponding-distant-metastases-an-autopsy-study-of-25-patients
#15
B Szekely, Zs I Nagy, Zs Farago, O Kiss, G Lotz, K A Kovacs, L Madaras, N Udvarhelyi, M Dank, Gy Szentmartoni, Zs Baranyai, L Harsanyi, A M Tőkés, Jozsef Timar, A M Szasz, J Kulka
Phenotypical change in metastatic breast carcinoma has widely been accepted as an inherent biological feature rather than technical fault. We analyzed the immunohistochemical phenotype and histopathological features of 25 primary breast carcinomas and 90 corresponding distant metastases in 23 organs retrospectively. Histological slides were reviewed for prognostic and predictive factors. Overall, metastases were more similar to each other and often differed from the primary tumor. We created a 3-step grouping system based on the localization of metastases...
January 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27885434/evaluation-of-mir-21-and-mir-375-as-prognostic-biomarkers-in-oesophageal-cancer-in-high-risk-areas-in-china
#16
Yutong He, Jing Jin, LiQun Wang, Yuejiao Hu, Di Liang, Huichai Yang, Yueping Liu, Baoen Shan
MicroRNAs have been associated with prognosis in oesophageal cancer (EC), suggesting that miRNAs could play a role in guiding treatment decisions. The aim of this study was to evaluate the prognostic potential of miRNAs found to be associated with zinc deficiency in a geographical area with a high incidence of EC. miRNAs found to be associated with zinc deficiency were isolated from EC cell lines cultured with various Zn levels. The expression levels of the miRNAs were quantified using qRT-PCR. The potential prognostic value of the selected miRNAs was assessed in a cohort study of 88 patients from an area in China with a high incidence of EC...
January 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27812769/use-of-non-invasive-imaging-to-monitor-response-to-aflibercept-treatment-in-murine-models-of-colorectal-cancer-liver-metastases
#17
Karianne G Fleten, Kine M Bakke, Gunhild M Mælandsmo, Andreas Abildgaard, Kathrine Røe Redalen, Kjersti Flatmark
The liver is the most frequent metastatic site in colorectal cancer (CRC), and relevant orthotopic in vivo models are needed to study the efficacy of anticancer drugs in the metastatic setting. A challenge when utilizing such models is monitoring tumor growth during the experiments. In this study, experimental liver metastases were established in nude mice by splenic injection of the CRC cell lines HT29 and HCT116, and the mice were treated with the antiangiogenic drug aflibercept. Tumor growth was monitored using magnetic resonance imaging (MRI) and bioluminescence imaging (BLI)...
January 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27770373/extracellular-matrix-1-ecm1-regulates-the-actin-cytoskeletal-architecture-of-aggressive-breast-cancer-cells-in-part-via-s100a4-and-rho-family-gtpases
#18
P Gómez-Contreras, J M Ramiro-Díaz, A Sierra, C Stipp, F E Domann, R J Weigel, G Lal
ECM1 overexpression is an independent predictor of poor prognosis in primary breast carcinomas, however the mechanisms by which ECM1 affects tumor progression have not been completely elucidated. ECM1 was silenced in the triple-negative breast cancer cell lines Hs578T and MDAMB231 using siRNA and the cells were evaluated for changes in morphology, migration, invasion and adhesion. Actin cytoskeleton alterations were evaluated by fluorescent staining and levels of activated Rho GTPases by pull down assays. ECM1 downregulation led to significantly diminished cell migration (p = 0...
January 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27744579/melanoma-cell-metastasis-via-p-selectin-mediated-activation-of-acid-sphingomyelinase-in-platelets
#19
Katrin Anne Becker, Nadine Beckmann, Constantin Adams, Gabriele Hessler, Melanie Kramer, Erich Gulbins, Alexander Carpinteiro
Metastatic dissemination of cancer cells is one of the hallmarks of malignancy and accounts for approximately 90 % of human cancer deaths. Within the blood vasculature, tumor cells may aggregate with platelets to form clots, adhere to and spread onto endothelial cells, and finally extravasate to form metastatic colonies. We have previously shown that sphingolipids play a central role in the interaction of tumor cells with platelets; this interaction is a prerequisite for hematogenous tumor metastasis in at least some tumor models...
January 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27730394/bif-1-promotes-tumor-cell-migration-and-metastasis-via-cdc42-expression-and-activity
#20
Cunzhen Zhang, Fenghua Liu, Haiyang Chen, Nan Li, Zaili Luo, Weixing Guo, Dandan Huang, Shanhua Tang, Honggang Wang, Shuqun Cheng, Zhong Li, Hongyang Wang
Tumor metastasis is the process by which tumor cells disseminate from tumors and enter nearby and distant microenvironments for new colonization. Bif-1 (BAX-interacting factor 1), which has a BAR domain and an SH3 domain, has been reported to be involved in cell growth, apoptosis and autophagy. However, the influence of Bif-1 on metastasis has been less studied. To understand the role of Bif-1 in metastasis, we studied the expression levels of Bif-1 in human HCC specimens using immunohistochemistry, a tissue microarray and quantitative PCR...
January 2017: Clinical & Experimental Metastasis
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