journal
MENU ▼
Read by QxMD icon Read
search

Clinical & Experimental Metastasis

journal
https://www.readbyqxmd.com/read/27888377/correlation-between-status-of-epidermal-growth-factor-receptor-mutation-and-distant-metastases-of-lung-adenocarcinoma-upon-initial-diagnosis-based-on-1063-patients-in-china
#1
Hongwei Li, Jianzhong Cao, Xiaqin Zhang, Xing Song, Weili Wang, Sufang Jia, Zhengran Li, Haixia Jia, Xing Cao, Wei Zhou, Jianhong Lian, Songye Han, Weihua Yang, Yanfen Xi, Shenming Lian, Haoxing Jing
The study aimed to explore the correlations between status of epidermal growth factor receptor (EGFR) mutations and distant metastases. A total of 1063 patients with lung adenocarcinoma indentified with status of EGFR mutations from August 2010 to May 2015 at Shanxi Cancer Hospital were enrolled. 456 patients were confirmed with EGFR mutations. The associations among EGFR mutations, clinical factors, and distant metastases at initial diagnosis were evaluated. Patients harboring EGFR mutation were more likely to be female (P < 0...
November 25, 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27885435/comparison-of-immunophenotypes-of-primary-breast-carcinomas-and-multiple-corresponding-distant-metastases-an-autopsy-study-of-25-patients
#2
B Szekely, Zs I Nagy, Zs Farago, O Kiss, G Lotz, K A Kovacs, L Madaras, N Udvarhelyi, M Dank, Gy Szentmartoni, Zs Baranyai, L Harsanyi, A M Tőkés, Jozsef Timar, A M Szasz, J Kulka
Phenotypical change in metastatic breast carcinoma has widely been accepted as an inherent biological feature rather than technical fault. We analyzed the immunohistochemical phenotype and histopathological features of 25 primary breast carcinomas and 90 corresponding distant metastases in 23 organs retrospectively. Histological slides were reviewed for prognostic and predictive factors. Overall, metastases were more similar to each other and often differed from the primary tumor. We created a 3-step grouping system based on the localization of metastases...
November 24, 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27885434/evaluation-of-mir-21-and-mir-375-as-prognostic-biomarkers-in-oesophageal-cancer-in-high-risk-areas-in-china
#3
Yutong He, Jing Jin, LiQun Wang, Yuejiao Hu, Di Liang, Huichai Yang, Yueping Liu, Baoen Shan
MicroRNAs have been associated with prognosis in oesophageal cancer (EC), suggesting that miRNAs could play a role in guiding treatment decisions. The aim of this study was to evaluate the prognostic potential of miRNAs found to be associated with zinc deficiency in a geographical area with a high incidence of EC. miRNAs found to be associated with zinc deficiency were isolated from EC cell lines cultured with various Zn levels. The expression levels of the miRNAs were quantified using qRT-PCR. The potential prognostic value of the selected miRNAs was assessed in a cohort study of 88 patients from an area in China with a high incidence of EC...
November 24, 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27812769/use-of-non-invasive-imaging-to-monitor-response-to-aflibercept-treatment-in-murine-models-of-colorectal-cancer-liver-metastases
#4
Karianne G Fleten, Kine M Bakke, Gunhild M Mælandsmo, Andreas Abildgaard, Kathrine Røe Redalen, Kjersti Flatmark
The liver is the most frequent metastatic site in colorectal cancer (CRC), and relevant orthotopic in vivo models are needed to study the efficacy of anticancer drugs in the metastatic setting. A challenge when utilizing such models is monitoring tumor growth during the experiments. In this study, experimental liver metastases were established in nude mice by splenic injection of the CRC cell lines HT29 and HCT116, and the mice were treated with the antiangiogenic drug aflibercept. Tumor growth was monitored using magnetic resonance imaging (MRI) and bioluminescence imaging (BLI)...
November 3, 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27770373/extracellular-matrix-1-ecm1-regulates-the-actin-cytoskeletal-architecture-of-aggressive-breast-cancer-cells-in-part-via-s100a4-and-rho-family-gtpases
#5
P Gómez-Contreras, J M Ramiro-Díaz, A Sierra, C Stipp, F E Domann, R J Weigel, G Lal
ECM1 overexpression is an independent predictor of poor prognosis in primary breast carcinomas, however the mechanisms by which ECM1 affects tumor progression have not been completely elucidated. ECM1 was silenced in the triple-negative breast cancer cell lines Hs578T and MDAMB231 using siRNA and the cells were evaluated for changes in morphology, migration, invasion and adhesion. Actin cytoskeleton alterations were evaluated by fluorescent staining and levels of activated Rho GTPases by pull down assays. ECM1 downregulation led to significantly diminished cell migration (p = 0...
October 21, 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27744579/melanoma-cell-metastasis-via-p-selectin-mediated-activation-of-acid-sphingomyelinase-in-platelets
#6
Katrin Anne Becker, Nadine Beckmann, Constantin Adams, Gabriele Hessler, Melanie Kramer, Erich Gulbins, Alexander Carpinteiro
Metastatic dissemination of cancer cells is one of the hallmarks of malignancy and accounts for approximately 90 % of human cancer deaths. Within the blood vasculature, tumor cells may aggregate with platelets to form clots, adhere to and spread onto endothelial cells, and finally extravasate to form metastatic colonies. We have previously shown that sphingolipids play a central role in the interaction of tumor cells with platelets; this interaction is a prerequisite for hematogenous tumor metastasis in at least some tumor models...
October 15, 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27730394/bif-1-promotes-tumor-cell-migration-and-metastasis-via-cdc42-expression-and-activity
#7
Cunzhen Zhang, Fenghua Liu, Haiyang Chen, Nan Li, Zaili Luo, Weixing Guo, Dandan Huang, Shanhua Tang, Honggang Wang, Shuqun Cheng, Zhong Li, Hongyang Wang
Tumor metastasis is the process by which tumor cells disseminate from tumors and enter nearby and distant microenvironments for new colonization. Bif-1 (BAX-interacting factor 1), which has a BAR domain and an SH3 domain, has been reported to be involved in cell growth, apoptosis and autophagy. However, the influence of Bif-1 on metastasis has been less studied. To understand the role of Bif-1 in metastasis, we studied the expression levels of Bif-1 in human HCC specimens using immunohistochemistry, a tissue microarray and quantitative PCR...
October 11, 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27718076/site-of-metastasis-and-breast-cancer-mortality-a-danish-nationwide-registry-based-cohort-study
#8
Anne Gulbech Ording, Uffe Heide-Jørgensen, Christian Fynbo Christiansen, Mette Nørgaard, John Acquavella, Henrik Toft Sørensen
Survival among patients with metastatic breast cancer may vary according to the site of metastasis and receptor status. We used Danish nationwide medical registries to establish a cohort of patients with metastatic breast cancer (870 with de novo metastatic disease and 3518 with recurrent disease with distant metastasis) diagnosed during 1997-2011. We examined 1-year and >1 to 5-year mortality associated with first site of metastasis and receptor expression status of the primary tumor. Cox proportional regression was used to compute confounder-adjusted mortality rate ratios (MRRs) associated with site of metastasis, stratified by receptor status...
October 7, 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27678280/introduction-of-revised-aims-and-scope-for-clinical-experimental-metastasis
#9
EDITORIAL
Jonathan P Sleeman
No abstract text is available yet for this article.
December 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27612856/mesothelial-cells-interact-with-tumor-cells-for-the-formation-of-ovarian-cancer-multicellular-spheroids-in-peritoneal-effusions
#10
Isabelle Matte, Clara Major Legault, Perrine Garde-Granger, Claude Laplante, Paul Bessette, Claudine Rancourt, Alain Piché
Epithelial ovarian cancer (EOC) dissemination is primarily mediated by the shedding of tumor cells from the primary site into ascites where they form multicellular spheroids that rapidly lead to peritoneal carcinomatosis. While the clinical importance and fundamental role of multicellular spheroids in EOC is increasingly appreciated, the mechanisms that regulate their formation and dictate their cellular composition remain poorly characterized. To investigate these important questions, we characterized spheroids isolated from ascites of women with EOC...
December 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27604552/impact-of-disease-free-status-on-prognosis-in-metastatic-non-small-round-cell-soft-tissue-sarcomas
#11
Hiroshi Urakawa, Eiji Kozawa, Kunihiro Ikuta, Shunsuke Hamada, Naoki Ishiguro, Yoshihiro Nishida
The aim of this study is to examine the impact of disease free (DF) status on the prognosis in patients with metastatic non-small round cell soft tissue sarcoma (STS). We retrospectively reviewed 51 metastatic STS patients who were treated in Nagoya University Hospital from 2005 to 2015. The relation between various clinical factors and overall survival (OS) was analyzed. The log rank test and Cox's proportional hazards test were used to evaluate the differences between groups. p-values of <0.05 were considered to indicate significance...
December 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27568374/a-journey-beyond-apoptosis-new-enigma-of-controlling-metastasis-by-pro-apoptotic-par-4
#12
REVIEW
Reyaz Ur Rasool, Debasis Nayak, Souneek Chakraborty, Archana Katoch, Mir Mohd Faheem, Hina Amin, Anindya Goswami
Prostate apoptotic response 4 (Par-4) is coined as a therapeutic protein since owing to its diverse physiologically relevant properties, especially in the cancer perspective. Albeit, Par-4 expression is not restricted to any specific tissue/organ, apart from cell death promotion (due to challenging threats), the other biological role of Par-4 is convincingly emerging. In the recent years, several laboratories have intended to dissect the signaling or mechanisms involved in Par-4 activation to augment apoptosis cascades but new developments in Par-4 research have widened its therapeutic potential...
December 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27565163/expression-of-natural-killer-cell-regulatory-microrna-by-uveal-melanoma-cancer-stem-cells
#13
Powrnima Joshi, Mitra Kooshki, Wayne Aldrich, Daniel Varghai, Maciej Zborowski, Arun D Singh, Pierre L Triozzi
Natural killer (NK) cells are implicated in the control of metastasis in uveal melanoma, a process that has been ascribed to its cancer stem cell subpopulation. NK cell activation is regulated by specific microRNA (miR). The NK cell sensitivity and regulatory miR production of uveal melanoma cancer stem cells was examined. Cancer stem cells enriched from aggressively metastatic MUM2B uveal melanoma cells by selecting CD271(+) cells or propagating as non-adherent spheres in stem-cell supportive were more resistant to NK cell cytolysis than cancer stem cells enriched from less aggressively metastatic OCM1 uveal melanoma cells...
December 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27553616/postoperative-carcinoembryonic-antigen-level-has-a-prognostic-value-for-distant-metastasis-and-survival-in-rectal-cancer-patients-who-receive-preoperative-chemoradiotherapy-and-curative-surgery-a-retrospective-multi-institutional-analysis
#14
Songmi Jeong, Taek Keun Nam, Jae Uk Jeong, Sung Hwan Kim, Kyubo Kim, Hong Seok Jang, Bae Kwon Jeong, Jong Hoon Lee
The cut-off value and prognostic significance of postoperative carcinoembryonic antigen (CEA) level in rectal cancer after preoperative chemoradiotherapy (CRT) and curative surgery are still unclear. 1559 rectal cancer patients staged with cT3-4N0-2M0 received preoperative CRT and total mesorectal excision (TME). CEA levels were measured before CRT and 3-4 weeks after surgery. Clinicopathologic factors that could be associated with tumor recurrence and patient survival were analyzed. The cumulative probability of tumor recurrence showed a steep increase with a cutoff value of 2...
December 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27541751/liver-metastatic-disease-new-concepts-and-biomarker-panels-to-improve-individual-outcomes
#15
REVIEW
Olga Golubnitschaja, Krishna Chander Sridhar
Liver cancer, one of the leading causes of all cancer related deaths, belongs to the most malignant cancer types. In fact, the secondary hepatic malignancies (liver metastases) are more common than the primary ones. Almost all solid malignancies can metastasise to the liver. It is well justified that the "treat and wait" approach in the overall management of the liver cancer is not up-to-date and so creation of complex individual patient profiles is needed. This review is specifically focused on the liver metastases originating from the colorectum, breast and prostate cancer...
December 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27530648/impact-of-primary-para-aortic-lymphadenectomy-on-distant-failure-in-locally-advanced-cervical-cancer-patients-treated-in-the-era-of-image-guided-adaptive-brachytherapy
#16
Cyrus Chargari, Renaud Mazeron, Ariane Dunant, Sébastien Gouy, Claire Petit, Pierre Maroun, Catherine Uzan, Pierre Annede, Enrica Bentivegna, Corinne Balleyguier, Catherine Genestie, Patricia Pautier, Alexandra Leary, Catherine Lhomme, Eric Deutsch, Philippe Morice, Christine Haie-Meder
To investigate the impact of a primary para-aortic lymphadenectomy (PAL) in locally advanced cervical cancer patients receiving definitive chemoradiation, we reviewed the clinical records of consecutive patients treated in our Institution and receiving an external beam irradiation followed with an image-guided adaptive brachytherapy for a locally advanced cervical cancer. We examined the impact of performing a primary PAL as part of primary staging for guiding irradiation fields in patients without extra-pelvic PET uptake...
December 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27510563/ectopic-expression-of-mcam-muc18-increases-in-vitro-motility-and-invasiveness-but-decreases-in-vivo-tumorigenesis-and-metastasis-of-a-mouse-melanoma-k1735-9-subline-in-a-syngeneic-mouse-model
#17
Guang-Jer Wu
Ectopic expression of MCAM/MUC18, a cell adhesion molecule in the immunoglobulin-like gene superfamily, induces two moMCAM/MUC18-minus, non-metastatic mouse melanoma K1735 sublines, K3 (tumor(+)/met(low)) and K10 (tumor(-)/met(low)), to metastasize to lungs in a syngeneic C3H mouse model. In this report, we extended investigation of effects of moMCAM/MUC18 expression on tumorigenesis and metastasis in another lowly metastatic, however highly tumorigenic moMCAM/MUC18-minus mouse melanoma K1735 subline, K9 (tumor(+++)/met(low))...
December 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27485175/prognostic-value-of-5-microrna-based-signature-in-t2-t3n0-colon-cancer
#18
Maciej Bobowicz, Marcin Skrzypski, Piotr Czapiewski, Michał Marczyk, Agnieszka Maciejewska, Michał Jankowski, Anna Szulgo-Paczkowska, Wojciech Zegarski, Ryszard Pawłowski, Joanna Polańska, Wojciech Biernat, Janusz Jaśkiewicz, Jacek Jassem
The role of adjuvant chemotherapy in stage T2-T3N0 colon cancer (CC) is controversial and there are currently no reliable factors allowing for individual selection of patients with high risk of relapse for such therapy. We searched for microRNA-based signature with prognostic significance in this group. We assessed by qRT-PCR expression of 754 microRNAs (miRNAs) in tumour samples from 85 stage pT2-3N0 CC patients treated with surgery alone. MiRNA expression was compared between two groups of patients: 40 and 45 patients who did and did not develop distant metastases after resection, respectively...
December 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27475809/cd4-foxp3-t-regulatory-cells-decrease-and-cd3-cd8-t-cells-recruitment-in-tils-from-melanoma-metastases-after-electrochemotherapy
#19
P Di Gennaro, G Gerlini, C Urso, S Sestini, P Brandani, N Pimpinelli, L Borgognoni
Electrochemotherapy (ECT) represents an effective local treatment for skin unresectable melanoma metastases with high overall objective response rate. ECT is based on the combination of anti-neoplastic drugs administration and cancer cells electroporation. Whether ECT can also activate the immune system is a matter of debate, however a significant recruitment of dendritic cells in melanoma treated metastases has been described. Herein we investigated immediate and late effects of ECT treatment on T cell subsets in ECT-treated lesions by fluorescent immunohistochemistry...
December 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27449756/tumor-infiltrating-lymphocyte-subsets-and-tertiary-lymphoid-structures-in-pulmonary-metastases-from-colorectal-cancer
#20
Thomas Schweiger, Anna Sophie Berghoff, Christoph Glogner, Olaf Glueck, Orsolya Rajky, Denise Traxler, Peter Birner, Matthias Preusser, Walter Klepetko, Konrad Hoetzenecker
The presence of tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) reflects an active inflammatory tumor microenvironment. High density of TILs as well as presence of TLS is associated with improved survival in various solid cancer types. We aimed to describe the density and distribution of TILs and TLS in pulmonary metastases (PMs) from primary colorectal cancer (CRC) and its correlation with clinicopathological variables. Fifty-seven CRC pulmonary metastasectomy specimen (PM) and 31 matched primary CRC specimen were included...
October 2016: Clinical & Experimental Metastasis
journal
journal
28855
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"