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Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine

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https://www.readbyqxmd.com/read/28513301/modern-strategies-and-capabilities-for-activation-of-the-immune-response-against-tumor-cells
#1
Sergey Vital'evich Sennikov, Julia Nikolaevna Khantakova, Ekaterina Vladimirovna Kulikova, Irina Alexandrovna Obleukhova, Julia Alexandrovna Shevchenko
Dendritic cells are professional antigen-presenting cells and the most potent stimulators of various immune responses, such as antitumor responses. Modern studies have not shown an effective antitumor immune response development in patients with malignant tumors. The major cause is the decrease in functional activity of dendritic cells in cancer patients through irregularities in the maturation process to a functionally active form and in the antigen presentation process to naive T lymphocytes. This review describes the main stages of cellular antitumor immune response induction in vitro, aimed at resolving the problems that are blocking the full functioning of dendritic cells, and additional stimulation of antitumor immune response...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28513300/s100a11-regulates-renal-carcinoma-cell-proliferation-invasion-and-migration-via-the-egfr-akt-signaling-pathway-and-e-cadherin
#2
Lin Liu, Long Miao, Yang Liu, Aihua Qi, Ping Xie, Jiacun Chen, Haitao Zhu
S100A11 is a S100 protein family member that contributes to cancer progression. Upregulated in human renal cancer tissues, S100A11 may be a prognostic marker for clear cell renal cell carcinoma, but how it functions in cancer is uncertain. Thus, we studied S100A11 and noted knockdown of S100A11 using short hairpin RNA, which inhibited proliferation, invasion, and migration of renal carcinoma cells as well as increased expression of E-cadherin and decreased expression of epidermal growth factor receptor/Akt in renal carcinoma cells...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28513299/anti-tumor-effect-of-cisplatin-in-human-oral-squamous-cell-carcinoma-was-enhanced-by-andrographolide-via-upregulation-of-phospho-p53-in-vitro-and-in-vivo
#3
Songjie Chen, Hui Hu, Shushu Miao, Jiayong Zheng, Zhijian Xie, Hui Zhao
Oral squamous cell carcinoma is one of the most common neoplasm in the world. Despite the improvements in diagnosis and treatment, the outcome is still poor now. Thus, the development of novel therapeuticapproaches is needed. The aim of this study is to assess the synergistic anti-tumor effect of andrographolide with cisplatin (DDP) in oral squamous cell carcinoma CAL-27 cells in vitro and in vivo. We performed Cell Counting Kit-8 proliferation assay, apoptosis assay, and western blotting on CAL-27 cells treated with andrographolide, DDP or the combination in vitro...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28488547/stimulatory-role-of-interleukin-10-in-cd8-t-cells-through-stats-in-gastric-cancer
#4
Jianjun Xi, Mingzheng Xu, Zongchang Song, Hongqiang Li, Shumin Xu, Chunmei Wang, Haihan Song, Jianwen Bai
CD8(+) T cells are considered to be critical in tumor surveillance and elimination. Increased CD8(+) T cell frequency and function is associated with better prognosis in cancer patients. Interleukin 10 is a cytokine with controversial roles in CD8(+) T cell-mediated anti-tumor immunity. We therefore examined the interleukin 10 expression and consumption in CD8(+) T cells harvested from the peripheral blood and resected tumors of gastric cancer patients of stages II-IV. We found that the gastric cancer patients presented significantly elevated frequencies of interleukin 10-expressing cells in both CD4(+) and CD8(+) T cells compared to healthy controls...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28488546/long-non-coding-rna-uca1-can-predict-tumor-lymph-node-metastasis
#5
Yuan-Hang Wang, Fang Wang, Lan Zhang, Jia-Chun Lu
Numerous studies suggested that long non-coding RNA UCA1 was highly expressed and played critical roles in the development and progression of various cancerous tissues and cells. However, little is known about the association between UCA1 and tumor lymph node metastasis. In our study, a systematic review was conducted to evaluate the association between UCA1 expression and tumor lymph node metastasis and explore whether UCA1 can be a potential molecular marker for predicting the multiple tumor lymph node metastasis...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28488545/determination-of-braf-v600e-ve1-protein-expression-and-braf-gene-mutation-status-in-codon-600-in-borderline-and-low-grade-ovarian-cancers
#6
Pawel Sadlecki, Pawel Walentowicz, Magdalena Bodnar, Andrzej Marszalek, Marek Grabiec, Malgorzata Walentowicz-Sadlecka
Epithelial ovarian tumors are a group of morphologically and genetically heterogeneous neoplasms. Based on differences in clinical phenotype and genetic background, ovarian neoplasms are classified as low-grade and high-grade tumor. Borderline ovarian tumors represent approximately 10%-20% of all epithelial ovarian masses. Various histological subtypes of ovarian malignancies differ in terms of their risk factor profiles, precursor lesions, clinical course, patterns of spread, molecular genetics, response to conventional chemotherapy, and prognosis...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28488544/a-long-non-coding-rna-lncrna-pe-promotes-invasion-and-epithelial-mesenchymal-transition-in-hepatocellular-carcinoma-through-the-mir-200a-b-zeb1-pathway
#7
Yuan Shen, Shanshan Liu, Hanyu Yuan, Xiaomin Ying, Hanjiang Fu, Xiaofei Zheng
Long non-coding RNAs have been revealed to play important roles in the progression of hepatocellular carcinoma. However, the detailed mechanisms underlying their activities are not fully understood. Using microarray technology, a number of long non-coding RNAs were previously identified to be aberrantly expressed in hepatocellular carcinoma. In this study, one of these long non-coding RNAs, designated lncRNA-PE (lncRNA promotes epithelial-mesenchymal transition), was further explored to study its expression profile and function...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28488543/the-transcription-factor-foxa1-induces-epithelial-ovarian-cancer-tumorigenesis-and-progression
#8
Li-Li Wang, Yin-Ling Xiu, Xi Chen, Kai-Xuan Sun, Shuo Chen, Dan-Dan Wu, Bo-Liang Liu, Yang Zhao
FOXA1 (forkhead box A1), a member of the FOXA transcription factor superfamily, plays an important role in tumor occurrence and development. However, the relationship between FOXA1 and ovarian cancer has not been reported. We examined normal ovarian tissue and ovarian cancer tissue and found increased FOXA1 expression in the cancer tissue. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and flow cytometry assays demonstrated that transfection with small interfering RNA to silence FOXA1 (si-FOXA1) in ovarian cancer cell lines decreased cell proliferation and induced apoptosis and S-phase arrest...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28488542/cxcl11-mediates-twist1-induced-angiogenesis-in-epithelial-ovarian-cancer
#9
Yu-Jin Koo, Tae-Jin Kim, Kyung-Jin Min, Kyeong-A So, Un-Suk Jung, Jin-Hwa Hong
To investigate the role of TWIST1 in tumor angiogenesis in epithelial ovarian cancer and to identify key molecules involved in angiogenesis. TWIST1 small interfering RNA was transfected into A2780 cells, while a complementary DNA vector was transfected into non-malignant human ovarian surface epithelial cells to generate a TWIST1-overexpressing cell line. To evaluate how this affects angiogenesis, human umbilical vein endothelial cell tube formation assays were performed using the control and transfected cell lines...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28488541/microrna-124-suppresses-proliferation-and-glycolysis-in-non-small-cell-lung-cancer-cells-by-targeting-akt-glut1-hkii
#10
Xiaojian Zhao, Caiping Lu, Weiwei Chu, Bing Zhang, Qiang Zhen, Renfeng Wang, Yaxiao Zhang, Zhe Li, Baolei Lv, Huixian Li, Jiabao Liu
Non-small cell lung cancer accounts for 85% of all types of lung cancer and is the leading cause of worldwide cancer-associated mortalities. MiR-124 is epigenetically silenced in various types of cancer and plays important roles in tumor development and progression. MiR-124 was also significantly downregulated in non-small cell lung cancer patients. Glycolysis has been considered as a feature of cancer cells; hypoxia-inducible factor 1-alpha/beta and Akt are key enzymes in the regulation of glycolysis and energy metabolism in cancer cells...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28488528/future-perspectives-of-circulating-tumor-dna-in-colorectal-cancer
#11
C Nadal, T Winder, A Gerger, David Tougeron
Tumor biopsy is currently the gold standard for diagnosis and in determining cell signaling pathways involved in the development of treatment resistance. However, there are major challenges with this technique, including the need for serial sampling to monitor treatment resistance, which is invasive and also has the potential for selection bias due to intra-tumoral and inter-tumoral heterogeneity. These challenges highlight the need for more effective methods for obtaining Tumor samples. Liquid biopsy analyzes genetic material or tumor cells shed into the blood from the primary tumor and metastatic sites and consequently provides a comprehensive, real-time picture of the tumor burden in an individual patient...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28488527/clinical-value-of-mir-452-5p-expression-in-lung-adenocarcinoma-a-retrospective-quantitative-real-time-polymerase-chain-reaction-study-and-verification-based-on-the-cancer-genome-atlas-and-gene-expression-omnibus-databases
#12
Xiao-Ning Gan, Jie Luo, Rui-Xue Tang, Han-Lin Wang, Hong Zhou, Hui Qin, Ting-Qing Gan, Gang Chen
The role and mechanism of miR-452-5p in lung adenocarcinoma remain unclear. In this study, we performed a systematic study to investigate the clinical value of miR-452-5p expression in lung adenocarcinoma. The expression of miR-452-5p in 101 lung adenocarcinoma patients was detected by quantitative real-time polymerase chain reaction. The Cancer Genome Atlas and Gene Expression Omnibus databases were joined to verify the expression level of miR-452-5p in lung adenocarcinoma. Via several online prediction databases and bioinformatics software, pathway and network analyses of miR-452-5p target genes were performed to explore its prospective molecular mechanism...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28488526/preliminary-evaluation-for-bit1-as-a-potential-biomarker-for-squamous-cell-carcinoma-and-adenocarcinoma-of-esophagus
#13
Jing Chen, Hongtao Liu, Pan Gao, Yiran Hui, Zhenzhen Yang, Xiaqing Zhang, Peirong Xu, Fang Tian, Tianli Fan
Mounting evidence has demonstrated that Bit1 has been investigated as an etiological factor for certain cancers, including esophageal squamous cell carcinoma reported in our previous study, but data regarding possible roles of Bit1 in esophageal squamous cell carcinoma and esophageal adenocarcinoma remain to be elucidated. The purpose of this study was to examine whether Bit1 can be a novel diagnostic marker for the patients with esophageal squamous cell carcinoma and esophageal adenocarcinoma. The results revealed that Bit1 level in esophageal squamous cell carcinoma was significantly higher than that in esophageal adenocarcinoma tissues ( p < 0...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28475017/hypoxia-induces-oncogene-yes-associated-protein-1-nuclear-translocation-to-promote-pancreatic-ductal-adenocarcinoma-invasion-via-epithelial-mesenchymal-transition
#14
Honglong Wei, Zongzhen Xu, Feng Liu, Fuhai Wang, Xin Wang, Xueying Sun, Jie Li
Pancreatic ductal adenocarcinoma is one of the most lethal cancers. The Hippo pathway is involved in tumorigenesis and remodeling of tumor microenvironments. Hypoxia exists in the microenvironment of solid tumors, including pancreatic ductal adenocarcinoma and plays a vital role in tumor progression and metastasis. However, it remains unclear how hypoxia interacts with the Hippo pathway to regulate these events. In this study, expressions of yes-associated protein 1 and hypoxia-inducible factor-1α were found to be elevated in pancreatic ductal adenocarcinoma samples compared with those in matched adjacent non-tumor samples...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28475016/dissecting-the-roles-of-the-androgen-receptor-in-prostate-cancer-from-molecular-perspectives
#15
Jieping Hu, Gongxian Wang, Ting Sun
Androgen receptor plays a pivotal role in prostate cancer progression, and androgen deprivation therapy to intercept androgen receptor signal pathway is an indispensable treatment for most advanced prostate cancer patients to delay cancer progression. However, the emerging of castration-resistant prostate cancer reminds us the alteration of androgen receptor, which includes androgen receptor mutation, the formation of androgen receptor variants, and androgen receptor distribution in cancer cells. In this review, we introduce the process of androgen receptor and also its variants' formation, translocation, and function alteration by protein modification or interaction with other pathways...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28475015/the-cngrcllii-klaklak-2-peptide-shows-cytotoxicity-against-huvecs-by-inducing-apoptosis-an-in-vitro-and-in-vivo-study
#16
Guanying Wang, Na Yuan, Shangke Huang, Lu Feng, Rui Han, Yujiao Zhang, Juan Ren, Min Meng, Xinhan Zhao
Fibrinogen Asn-Gly-Arg motif can specifically recognize and bind to Aminopeptidase N (CD13) on vascular endothelial cells in newly formed tumor vessels. Adipose-derived stem cells can serve as ideal vectors for gene therapy because of their ability of migrating to tumor tissues. First, this study was aimed to design a new peptide (CNGRCLLII(KLAKLAK)2) named CNAK which contains cyclic Asn-Gly-Arg motif and test its biological activity against human umbilical vein endothelial cells. Second, we aimed to construct stably transfected adipose-derived stem cells which express the CNAK peptide and investigate their anti-angiogenic activity in vivo...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28475014/ectopic-repression-of-receptor-tyrosine-kinase-like-orphan-receptor-2-inhibits-malignant-transformation-of-ovarian-cancer-cells-by-reversing-epithelial-mesenchymal-transition
#17
Ying Xu, Yan-Hui Ma, Ying-Xin Pang, Zhe Zhao, Jing-Jing Lu, Hong-Luan Mao, Pei-Shu Liu
Receptor tyrosine kinase-like orphan receptor 2 is an enzyme-linked receptor which specifically modulates WNT5A signaling and plays an important role in tumorigenesis, invasion, and metastasis; however, the precise role of receptor tyrosine kinase-like orphan receptor 2 in cancer is controversial. The purpose of this study was to investigate the expression and role of receptor tyrosine kinase-like orphan receptor 2 in ovarian carcinoma and clarify the biological functions and interactions of receptor tyrosine kinase-like orphan receptor 2 with non-canonical Wnt pathways in ovarian cancer...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28475013/evaluation-of-the-blood-supply-and-efficacy-of-transcatheter-arterial-chemoembolization-for-patients-with-liver-metastasis-using-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#18
Zu-Fei Wang, Xiao-Xi Fan, Min Xu, Min-Jiang Chen, Zhong-Wei Zhao, Jun-Dong Zhou, Jian-Fei Tu, Jing-Jing Song, Xiang-Hua Hu, Chen-Ying Lu, Fa-Zong Wu, Deng-Ke Zhang, Li Chen, Lu Liu, Xi-Hui Ying, Xiao-Fei Xu, Jian-Song Ji
Our study aims to evaluate the efficacy of transcatheter arterial chemoembolization in the treatment of patients with liver metastasis using integrated (18)F-fluorodeoxyglucose positron emission tomography/computed tomography. A total of 97 liver metastasis patients treated by transcatheter arterial chemoembolization were enrolled in this study. The (18)F-fluorodeoxyglucose positron emission tomography/computed tomography images of liver metastasis patients were collected before and after transcatheter arterial chemoembolization treatment...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28475012/the-role-of-sox6-and-netrin-1-in-ovarian-cancer-cell-growth-invasiveness-and-angiogenesis
#19
Yi Li, Ming Xiao, Fangchun Guo
SOX6 plays important roles in cell proliferation, differentiation, and cell fate determination. It has been confirmed that SOX6 is a tumor suppressor and downregulated in various cancers, including esophageal squamous cell carcinoma, hepatocellular carcinoma, and chronic myeloid leukemia. Netrin-1 is highly expressed in various human cancers and acts as an anti-apoptotic and proangiogenic factor to drive tumorigenesis. The role of SOX6 and netrin-1 in regulating the growth of ovarian tumor cells still remains unclear...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28475011/moschamine-inhibits-proliferation-of-glioblastoma-cells-via-cell-cycle-arrest-and-apoptosis
#20
George A Alexiou, Diamanto Lazari, Georgios Markopoulos, Evrysthenis Vartholomatos, Entela Hodaj, Vasiliki Galani, Athanasios P Kyritsis
Glioblastoma is the most common and most malignant primary brain tumor with a median survival of 15 months. Moschamine is an indole alkaloid that has a serotoninergic and cyclooxygenase inhibitory effect. In this study, we sought to determine whether moschamine could exert cytotoxic and cytostatic effects on glioma cells in vitro. Moschamine was tested for toxicity in zebrafish. We investigated the effect of moschamine on U251MG and T98G glioblastoma cell lines. Viability and proliferation of the cells were examined with trypan blue exclusion assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and the xCELLigence system...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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