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Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine

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https://www.readbyqxmd.com/read/30486767/total-cell-free-dna-carcinoembryonic-antigen-and-c-reactive-protein-for-assessment-of-prognosis-in-patients-with-metastatic-colorectal-cancer
#1
Karen-Lise Garm Spindler, Christina Demuth, Boe Sandahl Sorensen, Julia S Johansen, Dorte Nielsen, Niels Pallisgaard, Estrid Hoegdall, Per Pfeiffer, Benny Vittrup Jensen
In late-stage metastatic colorectal cancer, difficult treatment decisions should incorporate a thorough evaluation of the patient's general condition and subject for shared decision making. Assessment of the individual patients' prognosis is valuable in this setting. The aim was to analyze the prognostic value of plasma levels of total cell-free DNA, carcinoembryonic antigen and C-reactive protein in 97 heavily pretreated patients with metastatic colorectal cancer. Patients received irinotecan, cetuximab, and everolimus in a phase-2 clinical trial ( clinicaltrials...
November 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30486759/vdr-gene-foki-polymorphism-as-a-poor-prognostic-factor-for-papillary-thyroid-cancer
#2
Selvihan Beysel, Nilnur Eyerci, Ferda Alparslan Pinarli, Mahmut Apaydin, Muhammed Kizilgul, Mustafa Caliskan, Ozgur Ozcelik, Seyfullah Kan, Erman Cakal
This is the first study to investigate the effect of vitamin D receptor ( VDR) gene single-nucleotide polymorphisms on the clinicopathologic features of papillary thyroid cancer in Turkey. A total of 165 patients with papillary thyroid cancer and 172 controls were included in this case-control study. VDR gene single-nucleotide polymorphisms FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) were evaluated using reverse-transcription polymerase chain reaction. VDR gene polymorphisms BsmI, ApaI, and TaqI did not differ between the papillary thyroid cancer group and control group (p > 0...
November 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30486756/cell-adhesion-molecules-and-their-soluble-forms-promising-predictors-of-tumor-progression-and-relapse-in-leukemia
#3
Ieda Cristina Cunha Ferreira E Fonseca, Felipe Andrés Cordero da Luz, Isadora Akemi Uehara, Marcelo José Barbosa Silva
Some surface markers are used to discriminate certain leukemic subpopulations that retain a greater oncogenic potential than others, and, for this reason, they were termed as leukemic stem cells, similar to the concept of cancer stem cells in carcinoma. Among these surface markers are proteins involved in cell-cell adhesion or cell-matrix adhesion, and they may play a role in the relapse of leukemia, similar to metastasis in carcinomas. The most important are epithelial cadherin, neural cadherin, epithelial cell-adhesion molecule, and CD44, which can be cleaved and released, and their soluble forms were found increased in serum levels of cancer patients, being implicated, in some cases, with progression, metastases, and relapse...
November 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30486741/nivolumab-in-never-smokers-with-advanced-squamous-non-small-cell-lung-cancer-results-from-the-italian-cohort-of-an-expanded-access-program
#4
Marina Chiara Garassino, Lucio Crinò, Annamaria Catino, Andrea Ardizzoni, Enrico Cortesi, Federico Cappuzzo, Paola Bordi, Luana Calabrò, Fausto Barbieri, Antonio Santo, Giuseppe Altavilla, Francesca Ambrosio, Enrico Mini, Enrico Vasile, Floriana Morgillo, Alessandro Scoppola, Carmelo Bengala, Alessandro Follador, Natale Tedde, Diana Giannarelli, Giuseppe Lo Russo, Fabiana Vitiello
OBJECTIVES: Never-smokers may be a distinct subgroup among patients with advanced non-small cell lung cancer, appearing to benefit less from immunotherapy than smokers. We report results from never-smokers enrolled in the Italian cohort of the nivolumab expanded access program in pre-treated patients with advanced squamous non-small cell lung cancer. MATERIALS AND METHODS: Nivolumab (3 mg/kg every 2 weeks for ≤24 months) was available on physician request...
November 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30486739/b7-h3-and-b7-h4-expression-in-phyllodes-tumors-of-the-breast-detected-by-rna-in-situ-hybridization-and-immunohistochemistry-association-with-clinicopathological-features-and-t-cell-infiltration
#5
Ga-Eon Kim, Nah Ihm Kim, Min Ho Park, Ji Shin Lee
Phyllodes tumors are rare biphasic breast tumors with the potential for both local recurrence and distant metastasis. The aberrant expression of B7-H3 and B7-H4 B7 molecules could be potential targets for future development of immunotherapeutic approaches. This work was undertaken to evaluate the expression of B7-H3 and B7-H4 in phyllodes tumors and assess the association with the grade and clinical behavior of phyllodes tumors. In addition, the roles of B7-H3 and B7-H4 in the regulation of tumor immune surveillance were evaluated by assessing the relationship between B7-H3/B7-H4 expression and T-cell infiltration...
November 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30419802/the-relationship-between-chemokines-ccl2-ccl3-and-ccl4-with-the-tumor-microenvironment-and-tumor-associated-macrophage-markers-in-colorectal-cancer
#6
Marjorie De la Fuente López, Glauben Landskron, Daniela Parada, Karen Dubois-Camacho, Daniela Simian, Maripaz Martinez, Diego Romero, Juan Carlos Roa, Isidora Chahuán, Rocío Gutiérrez, Francisco Lopez-K, Karin Alvarez, Udo Kronberg, Sebastian López, Antonella Sanguinetti, Natalia Moreno, Mario Abedrapo, María-Julieta González, Rodrigo Quera, Marcela A Hermoso-R
A complex network of chemokines can influence cancer progression with the recruitment and activation of hematopoietic cells, including macrophages to the supporting tumor stroma promoting carcinogenesis and metastasis. The aim of this study was to investigate the relation between tissue and plasma chemokine levels involved in macrophage recruitment with tumor-associated macrophage profile markers and clinicopathological features such as tumor-node-metastases stage, desmoplasia, tumor necrosis factor-α, and vascular endothelial growth factor plasma content...
November 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30419801/dysregulated-cancer-cell-transdifferentiation-into-erythrocytes-is-an-additional-metabolic-stress-in-hepatocellular-carcinoma
#7
Abigail Hughes, Gurtej K Dhoot
A number of human and canine hepatocellular carcinoma tissues showed clear signs of hypoxia indicated by HIF1α-activation and the presence of large clusters of cells resembling erythrocytes at different stages of nuclear elimination without any defined endothelial cell lining or blood vessel walls. Differentiated erythrocytic identity of such cells in hepatocellular carcinoma tissues was apparent from their non-nucleated and evolving basophilic to eosinophilic staining characteristics. In addition to the fully differentiated non-nucleated mesenchymal cell clusters, the onset of erythroblastic transdifferentiation was apparent from the activation of Glycophorin A, a marker of erythrocytic progenitors, in some epithelial cancer cells...
November 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30400755/microrna-23b-and-microrna-27b-plus-flutamide-treatment-enhances-apoptosis-rate-and-decreases-ccng1-expression-in-a-castration-resistant-prostate-cancer-cell-line
#8
Ruan Ca Pimenta, Nayara I Viana, Gabriela Q Amaral, Rubens Park, Denis R Morais, José Pontes, Vanessa R Guimaraes, Juliana A Camargo, Kátia Rm Leite, William C Nahas, Miguel Srougi, Sabrina T Reis
The acquisition of a castration-resistant prostate cancer phenotype by prostate cancer cells is the alteration that has the worst prognosis for patients. The aim of this study was to evaluate the role of the microRNAs-23b/-27b as well as the possible CCNG1 target gene in tissue samples from patients with localized prostate cancer that progressed to castration-resistant prostate cancer and in a castration-resistant prostate cancer cell line (PC-3). The microRNAs and target gene expression levels of the surgical specimens were analyzed by quantitative real-time polymerase chain reaction...
November 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30375264/dual-loss-of-usp10-and-p14arf-protein-expression-is-associated-with-poor-prognosis-in-patients-with-small-intestinal-adenocarcinoma
#9
Joon Seon Song, Joo Mi Yi, Hanbyoul Cho, Chel Hun Choi, Yoonho Park, Eun Joo Chung, Jaewhan Song, Joon-Yong Chung, Seung-Mo Hong
Oncogene-induced senescence occurs following oncogene activation in normal cells and is considered as a critical tumor-suppressing mechanism. Ubiquitin-specific protease 10 (USP10) has been reported to play a vital role in oncogene-induced senescence via the deubiquitination-dependent stabilization of p14ARF. However, knowledge of the clinical significance of USP10 and p14ARF expression in patients with small intestinal adenocarcinoma is limited. To study the clinical significance of USP10 and p14ARF expression, we performed immunohistochemistry for USP10 and p14ARF on 195 surgically resected small intestinal adenocarcinoma specimens...
October 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30360692/tamoxifen-suppresses-paclitaxel-vincristine-and-bortezomib-induced-neuropathy-via-inhibition-of-the-protein-kinase-c-extracellular-signal-regulated-kinase-pathway
#10
Masanobu Tsubaki, Tomoya Takeda, Mikihiro Matsumoto, Natsuki Kato, Shota Yasuhara, Yu-Ichi Koumoto, Motohiro Imano, Takao Satou, Shozo Nishida
Chemotherapy-induced neuropathy is a highly problematic, dose-limiting effect of potentially curative regimens of cancer chemotherapy. When neuropathic pain is severe, patients often either switch to less-effective chemotherapy agents or choose to discontinue chemotherapy entirely. Conventional chemotherapy drugs used to treat lung and breast cancer, multiple myeloma, and lymphoma include paclitaxel, vincristine, and bortezomib. Approximately 68% of patients receiving these anticancer drugs develop neuropathy within the first month of treatment, and while strategies to prevent chemotherapy-induced neuropathy have been investigated, none have yet been proven as effective...
October 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30319054/assessment-of-the-clinicopathological-relevance-of-mesothelin-level-in-plasma-peritoneal-fluid-and-tumor-tissue-of-epithelial-ovarian-cancer-patients
#11
Karolina Okła, Justyna Surówka, Karolina Frąszczak, Arkadiusz Czerwonka, Katarzyna Kaławaj, Anna Wawruszak, Jan Kotarski, Iwona Wertel
Ovarian cancer remains the most lethal gynecologic malignancy. This is due to lack of effective screening, diagnosis predominance in late stage of disease, a high recurrence rate after primary therapy, and poor treatment response in platinum-resistant tumor. Thus, unique biomarkers, predictive of individual disease course, and prognosis are urgently needed. The aim of our study was to assess the clinicopathological significance of plasma, peritoneal fluid, and tumor tissue levels of mesothelin in epithelial ovarian cancer patients...
October 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30261823/deep-learning-approach-for-survival-prediction-for-patients-with-synovial-sarcoma
#12
Ilkyu Han, June Hyuk Kim, Heeseol Park, Han-Soo Kim, Sung Wook Seo
Synovial sarcoma is a rare disease with diverse progression characteristics. We developed a novel deep-learning-based prediction algorithm for survival rates of synovial sarcoma patients. The purpose of this study is to evaluate the performance of the proposed prediction model and demonstrate its clinical usage. The study involved 242 patients who were diagnosed with synovial sarcoma in three institutions between March 2001 and February 2013. The patients were randomly divided into a training set (80%) and a testing set (20%)...
September 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30261820/sequence-analysis-of-cell-free-dna-derived-from-cultured-human-bone-osteosarcoma-143b-cells
#13
Abel Jacobus Bronkhorst, Johannes F Wentzel, Vida Ungerer, Dimetrie L Peters, Janine Aucamp, Etienne Pierre de Villiers, Stefan Holdenrieder, Piet J Pretorius
The true importance of cell-free DNA in human biology, together with the potential scale of its clinical utility, is tarnished by a lack of understanding of its composition and origin. In investigating the cell-free DNA present in the growth medium of cultured 143B cells, we previously demonstrated that the majority of cell-free DNA is neither a product of apoptosis nor necrosis. In the present study, we investigated the composition and origin of this cell-free DNA population using next-generation sequencing...
September 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30246618/toll-like-receptor-2-and-toll-like-receptor-4-predict-favorable-prognosis-in-local-pancreatic-cancer
#14
Mira A Lanki, Hanna E Seppänen, Harri K Mustonen, Camilla Böckelman, Anne T Juuti, Jaana K Hagström, Caj H Haglund
Toll-like receptors play an essential role in our innate immune system and are a focus of interest in contemporary cancer research. Thus far, Toll-like receptors have shown promising prognostic value in carcinomas of the oral cavity, colon, and ovaries, but the prognostic role of Toll-like receptors in pancreatic ductal adenocarcinoma has not been established. We set out to investigate whether Toll-like receptor expression could serve in prognostic evaluation in pancreatic ductal adenocarcinoma, as well. Our study comprised 154 consecutive stage I-III pancreatic ductal adenocarcinoma patients surgically treated at Helsinki University Hospital between 2002 and 2011...
September 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30226114/effect-of-pseuderanthemum-palatiferum-nees-radlk-fresh-leaf-ethanolic-extract-on-human-breast-cancer-mda-mb-231-regulated-cell-death
#15
Phimphan Komonrit, Ratana Banjerdpongchai
Leaf extracts of Pseuderanthemum palatiferum (Nees) Radlk were investigated for their effects on human breast cancer MDA-MB-231 cell growth inhibition. Pseuderanthemum palatiferum (Nees) Radlk extracts were prepared using fresh or dried leaves and extracted by either water or 95% ethanol, respectively. Fresh leaf ethanolic extract was the most toxic to MDA-MB-231 cells measured by 3-(4,5-dimethyl)-2,5-diphenyl tetrazolium bromide assay. Fresh leaf ethanolic extract-treated MDA-MB-231 cell death was stained with propidium iodide and examined under fluorescence microscopy...
September 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30226113/targeted-next-generation-sequencing-of-50-cancer-related-genes-in-japanese-patients-with-oral-squamous-cell-carcinoma
#16
Takafumi Nakagaki, Miyuki Tamura, Kenta Kobashi, Akina Omori, Ryota Koyama, Masashi Idogawa, Kazuhiro Ogi, Hiroyoshi Hiratsuka, Takashi Tokino, Yasushi Sasaki
Somatic mutation analysis is a standard of practice for human cancers to identify therapeutic sensitization and resistance mutations. We performed a multigene sequencing screen to explore mutational hotspots in cancer-related genes using a semiconductor-based sequencer. DNA from oral squamous cell carcinoma samples was used as a template to amplify 207 regions from 50 cancer-related genes. Of the 80 oral squamous cell carcinoma specimens from Japanese patients, including formalin-fixed paraffin-embedded samples, 56 specimens presented at least one somatic mutation among the 50 investigated genes, and 17 of these samples showed multiple gene somatic mutations...
September 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30207200/acetylcholine-induces-stem-cell-properties-of-gastric-cancer-cells-of-diffuse-type
#17
Phu Hung Nguyen, Yann Touchefeu, Tony Durand, Philippe Aubert, Emilie Duchalais, Stanislas Bruley des Varannes, Christine Varon, Michel Neunlist, Tamara Matysiak-Budnik
Gastric cancer is the third leading cause of cancer-related death worldwide, but the mechanisms of gastric carcinogenesis are not completely understood. Recently, the role of cholinergic neuronal pathways in promoting this process has been demonstrated. Our aim was to extend these studies and to evaluate, using an in vitro model of tumorspheres, the effect of acetylcholine on human gastric cancer cells, and the role of acetylcholine receptors and of the nitric oxide pathway, in this effect. The gastric cancer cell line MKN-45 of the diffuse type of gastric cancer was cultured in the presence of acetylcholine, or different agonists or inhibitors of muscarinic and nicotinic acetylcholine receptors, or nitric oxide donor or inhibitor of the nitric oxide pathway, and the number and size of tumorspheres were assessed...
September 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30204063/are-localized-prostate-cancer-biomarkers-useful-in-the-clinical-practice
#18
REVIEW
Arie Carneiro, Paulo Priante Kayano, Álan Roger Gomes Barbosa, Marcelo Langer Wroclawski, Carolina Ko Chen, Giulio Costa Cavlini, Guilherme Jose Reche, Rafael Sanchez-Salas, Marcos Tobias-Machado, Adam G Sowalsky, Bianca Bianco
Prostate cancer presents itself in a heterogeneous way with both aggressive and indolent forms. Despite the controversy surrounding its use, prostate-specific antigen screening ultimately leads to a greater number of diagnosed patients. One of the biggest challenges in clinical practice is to select the right patients for biopsy and, among diagnosed patients, to differentiate tumors with an indolent course from those with an unfavorable prognosis, in order to determine the best therapeutic decision for each case, avoiding unnecessary interventions...
September 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30198422/lymph-node-cxcl17-messenger-rna-a-new-prognostic-biomarker-for-colon-cancer
#19
Yomna Rashad, Lina Olsson, Anne Israelsson, Åke Öberg, Gudrun Lindmark, Marie-Louise Hammarström, Sten Hammarström, Basel Sitohy
Lymph node metastasis is the most important prognostic characteristic of colorectal cancer. Carcinoembryonic antigen messenger RNA was shown to detect tumor cells that have disseminated to lymph nodes of colorectal cancer patients and to be at least as good as the hematoxylin and eosin method to predict survival in colorectal cancer patients. CXCL17 was recently shown to be ectopically expressed in colon cancer tumors. Therefore, CXCL17 may serve as prognostic marker alone or in combination with carcinoembryonic antigen...
September 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/30192208/clinically-relevant-radioresistant-cells-exhibit-resistance-to-h-2-o-2-by-decreasing-internal-h-2-o-2-and-lipid-peroxidation
#20
Kazuo Tomita, Yoshikazu Kuwahara, Yuko Takashi, Kento Igarashi, Taisuke Nagasawa, Hideki Nabika, Akihiro Kurimasa, Manabu Fukumoto, Yoshihiro Nishitani, Tomoaki Sato
Radiation therapy is one of the choices to treat malignant tumors. In radiation therapy, existence of radiation-resistant cell is a major problem to overcome. We established clinically relevant radioresistant cells that had been obtained by exposing to 2 Gy/day X-rays for more than 30 days. These cells are resistant to 2 Gy/day X-ray exposure and anticancer agents. However, the underlying resistance mechanism remains unclear. We investigated the resistance of clinically relevant radioresistant cells to hydrogen peroxide (H2 O2 ), confirming a degree of resistance...
September 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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