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Neuro-ophthalmology

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https://www.readbyqxmd.com/read/29344076/response-to-dr-pellegrini-regarding-comments-on-bilateral-non-arteritic-anterior-ischaemic-optic-neuropathy-as-the-presentation-of-systemic-amyloidosis
#1
M Z Kanaan, R Pandit, Margaret Dayan
No abstract text is available yet for this article.
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344075/reply-to-bilateral-non-arteritic-anterior-ischaemic-optic-neuropathy-as-the-presentation-of-systemic-amyloidosis
#2
Francesco Pellegrini, Daniele Cirone, Luca De Simone, Luca Cimino, Cristina Ciabattoni
No abstract text is available yet for this article.
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344074/proceedings-of-the-38th-annual-upper-midwest-neuro-ophthalmology-group-meeting-july-28-2017-chicago-illinois-usa
#3
Jonathan D Trobe
No abstract text is available yet for this article.
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344073/bilateral-non-arteritic-anterior-ischaemic-optic-neuropathy-as-the-presentation-of-systemic-amyloidosis
#4
M Z Kanaan, A R Lorenzi, N Thampy, R Pandit, Margaret Dayan
A 75-year-old hypertensive female with stable idiopathic intermediate uveitis presented with bilateral sequential optic neuropathy with optic disc swelling. The optic neuropathy in the first affected eye (right) was thought to be due to non-arteritic anterior ischaemic optic neuropathy (NAION). Asymptomatic left optic disc swelling was found at routine review 2 months later, and a diagnosis of giant cell arteritis (GCA) was sought. Temporal artery duplex ultrasound showed the "halo sign," but a subsequent temporal artery biopsy showed light-chain (AL) amyloidosis with no signs of giant cell arteritis...
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344072/bilateral-compressive-optic-neuropathy-from-renal-osteodystrophy-caused-by-branchio-oto-renal-syndrome-stabilised-after-parathyroidectomy
#5
Arun N E Sundaram, Archana Abhayambika, Sunil Kumar
Renal osteodystrophy can cause calvarial hypertrophy and narrowing of the neural canals and foramina. Compressive optic neuropathy is extremely rare in renal osteodystrophy and was reported once only. The authors report bilateral, simultaneous compressive optic neuropathy secondary to renal osteodystrophy with features of uremic leontiasis ossea in chronic renal failure caused by branchio-oto-renal syndrome. Because of the extensive calvarial hypertrophy and the surgical difficulties envisaged with optic canal decompression, conservative approach was pursued...
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344071/acetazolamide-a-new-treatment-for-visual-vertigo
#6
Ilya M Sluch, Michael S Elliott, Justin Dvorak, Kai Ding, Bradley K Farris
Visual vertigo is a disorder characterised by symptoms of dizziness, vertigo, unsteadiness, disorientation, and general discomfort induced by visual triggers. It is currently treated with vestibular rehabilitation therapy, with no effective pharmacotherapy available for treatment-resistant cases. The objective of this study was to evaluate the efficacy of oral acetazolamide in improving symptoms of visual vertigo. A comparative case series of adult patients clinically diagnosed with visual vertigo was conducted from January 1992 to May 2015...
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344070/diffuse-colour-discrimination-as-marker-of-afferent-visual-system-dysfunction-in-amyotrophic-lateral-sclerosis
#7
Lindsay Boven, Qin Li Jiang, Heather E Moss
Abnormalities of the inner and intermediate retinal structures in patients with amyotrophic lateral sclerosis (ALS) have been described using optical coherence tomography and histopathology. Colour vision is a potential marker of these structural changes. The purpose of this study is to test the hypothesis that colour vision impairment is associated with ALS. Monocular (right eye) colour vision was assessed in subjects with definite or probable ALS (n = 25, aged 50-80 years) and control (n = 21, aged 46-89 years) subjects with corrected near visual acuity of at least 20/40 using the L'Anthony D15 color test (desaturated), scored by c-index, a measure of diffuse colour discrimination...
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344069/pituitary-ring-sign-plus-sphenoid-sinus-mucosal-thickening-neuroimaging-signs-of-pituitary-apoplexy
#8
REVIEW
Michael S Vaphiades
Two magnetic resonance imaging (MRI) signs of pituitary apoplexy are the "pituitary ring sign" and "sphenoid sinus mucosal thickening". The occurrence of both these MRI signs together in patients with ischaemic pituitary apoplexy was investigated. A literature review searching the terms "pituitary ring sign" and "sphenoid sinus mucosal thickening" in the context of pituitary apoplexy from 1990 until present was performed. To be included in the study, each case had to have ischaemic pituitary apoplexy defined as acute expansion of a pituitary adenoma or, less commonly, in a non-adenomatous gland, from infarction without haemorrhage or very little haemorrhage and a T1-weighted MRI of the brain with contrast that displayed both "sphenoid sinus mucosal thickening" and a "pituitary ring sign" either on an actual study (the author's cases) or in a figure in an article from the literature that could be reviewed and clearly illustrate these two signs...
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344068/clinical-versus-evidence-based-rehabilitation-options-for-post-stroke-visual-impairment
#9
REVIEW
K L Hanna, F J Rowe
The aim of this study was to identify which treatments for post-stroke visual impairment have a supportive evidence base, and which are being used in practice without supportive evidence. A systematic review of the literature reporting on the available treatment options was compared against the visual treatments used in the Vision In Stroke (VIS) study. Treatments were identified for visual field, visual neglect, visual perception and ocular motility disorders. Visual scanning therapies for hemianopia and neglect have an established evidence base...
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29339965/bilateral-radiation-optic-neuropathy-following-concurrent-chemotherapy-and-radiation-in-glioblastoma
#10
Jigisha P Thakkar, John T Slevin, Charles D Smith, Padmaja Sudhakar, William St Clair, John L Villano
Radiation optic neuropathy (RON) is an iatrogenic complication that causes severe, irreversible vision loss within months to years following radiation to lesions close to the visual pathway. The authors describe a case of RON in glioblastoma after radio-sensitisation with temozolomide with sequential involvement of both optic nerves. This case provides a timeline for clinical and imaging findings with RON and specifically resolution of nerve enhancement. The authors also highlight the potential of an increase in incidence of RON in glioblastoma with advances in survival seen with greater use of second-line chemotherapy and even re-radiation...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29339964/cerebral-venous-thrombosis-with-papilloedema-secondary-to-skull-base-plasmacytoma
#11
Peter W MacIntosh, Amy Y Lin, Jin Suh Kim, Fernando D Testai, Heather E Moss
A 60-year-old woman with history of multiple myeloma was in remission after stem cell transplant 6 years prior. She was undergoing work-up for headaches that were thought to be secondary to a right mastoiditis seen on magnetic resonance imaging (MRI). On routine eye exam, papilloedema was noted. A lumbar puncture was performed, with elevated opening pressure with normal constituents. She was an atypical age for idiopathic intracranial hypertension, and her mastoiditis raised concern for secondary cerebral venous sinus thrombosis...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29339963/infiltrative-optic-neuropathies-opening-doors-to-sinister-pathologies
#12
Aastha Takkar, Darakshan Naheed, Mohit Dogra, Manoj K Goyal, Ramandeep Singh, Nalini Gupta, Kirti Gupta, B R Mittal, Vivek Lal
Optic disc edema may be caused by a number of conditions. A commonly ignored but important aspect is the presence of "infiltration" of disc; that may closely mimic disc edema. Disc edema, optic nerve dysfunction and a normal appearing disc in any combination may occur in infiltrative optic neuropathies. Identifying disc infiltration can aid in diagnosis of many sinister pathologies even in the absence of other specific clinical features. We describe two patients presenting with optic nerve dysfunction and infiltrated disc appearance, which on investigations were found to have underlying malignancies thereby underscoring the importance of detecting infiltrative optic neurpathies...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29339962/three-new-pax2-gene-mutations-in-patients-with-papillorenal-syndrome
#13
Alberto Galvez-Ruiz, Anthony J Lehner, Alicia Galindo-Ferreiro, Patrik Schatz
Papillorenal syndrome (PAPRS; Mendelian Inheritance in Man [MIM] 120330) is an autosomal dominant disease characterised by the presence of congenital renal and optic nerve abnormalities associated with mutations of the PAX2 gene. In this article, the authors present four patients with PAPRS who are carriers of three new PAX2 mutations, as well as another patient with a possible non-pathogenic variant of the PAX2 gene. All patients were given a full neurophthalmological examination, and all patients underwent a genetic test for PAX2...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29339961/skew-deviation-and-partial-ocular-tilt-reaction-due-to-intratympanic-gentamicin-injection-with-review-of-the-literature
#14
Samuel M Dresner, Nathan H Kung, Joel R Palko, Jonathan L McJunkin, Joel A Goebel, Gregory P Van Stavern
Skew deviation is a rare side effect of intratympanic gentamicin injection for intractable Meniere's disease. When the skew deviation is accompanied by pathologic head tilt and ocular torsion, the result is an ocular tilt reaction (OTR). The authors report the case of a 56-year-old man with refractory Meniere's disease who developed binocular vertical diplopia following intratympanic gentamicin injection and was found to have skew deviation and a partial ocular tilt reaction. The authors also review the reported cases of skew deviation following intratympanic gentamicin and confirm this phenomenon, which has only rarely been reported in the literature...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29339960/which-differences-in-priming-effect-between-neglect-and-hemianopia-a-case-description-of-a-bilateral-brain-lesioned-patient
#15
Matteo Sozzi, Stefania Bianchi Marzoli, Lisa Melzi, Massimo Corbo, Irene Venturella, Michela Balconi
It is widely known that visuospatial neglect and hemianopia maybe superimposed. We considered the differences in implicit information processing which is effective in patients with neglect but not with hemianopia. We then hypothesize that a prime-word in the neglected field should determine a semantic activation effect but not in a blind hemifield. Moreover eye movements could provide further details. In this work we considered a patient with a bilateral with the presence of either a left visual neglect and a right homonymous hemianopia...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29339959/medical-cannabis-a-beneficial-high-in-treatment-of-blepharospasm-an-early-observation
#16
Phillip M Radke, Ali Mokhtarzadeh, Michael S Lee, Andrew R Harrison
The objective of this study was to observe the effect of medical cannabis in benign essential blepharospasm (BEB) as an adjunct to botulinum toxin. A retrospective chart review was performed on patients certified for medical cannabis use for BEB from September 2015 to May 2016. Patient demographics and responses, cannabis history, and severity indices were collected. Ten patients were certified for medical cannabis use. Five met the inclusion criteria, which was any patient with a diagnosis of BEB receiving standard botulinum toxin treatment who had started medical cannabis treatment by a registered distributor within the state, and was contactable by phone...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29339958/validation-of-simplified-visual-acuity-testing-protocols-in-amyotrophic-lateral-sclerosis
#17
Lindsay C Boven, Qin Li Jiang, Heather E Moss
High- and low-contrast visual acuity (HCVA, LCVA) are potential quantitative markers of neurological dysfunction in amyotrophic lateral sclerosis (ALS). The complex nature and duration of gold standard (GS) protocols precludes widespread use in neurology settings. This study compares simplified to GS visual acuity (VA) protocols. Monocular HCVA and LCVA were measured in ALS (n = 10) and control (n = 4) subjects using six protocols, varying by two chart and three refraction methods. Intraclass correlation coefficients between simplified and GS protocols ranged from 0...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29339957/a-case-of-synchronised-pupillary-and-nasal-cycling-evidence-for-a-central-autonomic-pendulum
#18
Fion D Bremner, Jonas Gälldin Nordström
We previously reported that some healthy individuals show alternating anisocoria. We now describe one such individual who also exhibits a classic nasal cycle (alternating periods of nasal congestion and decongestion). We made measurements of his pupil asymmetry and nasal asymmetry at 21 different time points and found that these variables were always synchronised such that greater nasal airflow was invariably found on the same side as the larger pupil. We hypothesise that a common central oscillator may be responsible for co-modulating the sympathetic outflow to both nasal vessels and iris dilator muscles in some healthy individuals...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344067/corrigendum
#19
(no author information available yet)
[This corrects the article DOI: 10.1080/01658107.2016.1263343.].
August 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344066/diagnostic-challenge-sequential-unilateral-cranial-neuropathies-due-to-perineural-spread-of-carcinoma
#20
Heather E Moss, Peter W MacIntosh, Konstantin V Slavin, John M Collins
An 86-year old man developed sequential dysfunction of trigeminal (V1), facial, abducens, trigeminal (v2), oculomotor, and hypoglossal cranial nerves on the right over 20 months. Magnetic resonance imaging (MRI) showed a lesion in the right cavernous sinus. Although there was clinical suspicion that this was related to perineural spread of an extracranial tumour, a primary lesion was not discovered. Stereotactic biopsies of the intracranial lesion were non-diagnostic, and the patient succumbed to his tumour following a period of rapid growth...
August 2017: Neuro-ophthalmology
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