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Endocrine Research

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https://www.readbyqxmd.com/read/30198791/endocrine-complications-of-celiac-disease-a-case-report-and-review-of-the-literature
#1
Marcella D Walker, Haley M Zylberberg, Peter H R Green, Michael S Katz
PURPOSE: The purpose of this article is to review recent literature regarding endocrine disorders related to celiac disease (CD). METHODS: We describe a case report and review existing literature on the endocrine manifestations of CD. RESULTS: CD is an autoimmune disorder characterized by intestinal inflammation in response to gluten. CD can cause a wide range of extra-intestinal complications, including endocrine manifestations. Metabolic bone disease including osteoporosis and osteopenia, vitamin D deficiency, secondary hyperparathyroidism and less frequently osteomalacia can be seen...
September 10, 2018: Endocrine Research
https://www.readbyqxmd.com/read/30182761/a-subset-of-patients-with-acquired-partial-lipodystrophy-developing-severe-metabolic-abnormalities
#2
Basak Ozgen Saydam, Melda Sonmez, Ilgin Yildirim Simsir, Mehmet Sercan Erturk, Mustafa Kulaksizoglu, Tugba Arkan, Zeliha Hekimsoy, Umit Cavdar, Gulcin Akinci, Tevfik Demir, Canan Tuncer Altay, Ercan Mihci, Mustafa Secil, Baris Akinci
Purpose/Aim of the study: Acquired partial lipodystrophy (APL) is a rare disease characterized by selective loss of adipose tissue. In this study, we aimed to present a subset of patients with APL, who developed severe metabolic abnormalities, from our national lipodystrophy registry. MATERIALS AND METHODS: Severe metabolic abnormalities were defined as: poorly controlled diabetes (HbA1c above 7% despite treatment with insulin more than 1 unit/kg/day combined with oral antidiabetics), severe hypertriglyceridemia (triglycerides above 500 mg/dL despite treatment with lipid-lowering drugs), episodes of acute pancreatitis, or severe hepatic involvement (biopsy-proven non-alcoholic steatohepatitis (NASH))...
September 5, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29979896/growth-hormone-therapy-in-children-with-idiopathic-short-stature-the-effect-on-appetite-and-appetite-regulating-hormones-a-pilot-study
#3
Michal Yackobovitch-Gavan, Galia Gat-Yablonski, Biana Shtaif, Shir Hadani, Shiran Abargil, Moshe Phillip, Liora Lazar
AIM: To investigate the effect of growth hormone (GH) therapy on appetite-regulating hormones and to examine the association between these hormones and the response to GH, body composition, and resting energy expenditure (REE). METHODS: Nine pre-pubertal children with idiopathic short stature underwent a standard meal test before and 4 months following initiation of GH treatment. Ghrelin, GLP-1, leptin, and insulin levels were measured; area under the curve (AUC) was calculated...
July 6, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29652557/skeletal-response-to-treatment-with-teriparatide-tpd-after-bisphosphonate-in-post-menopausal-women-with-osteoporosis-and-a-high-prevalence-of-secondary-risk-factors-in-real-life-setting-of-a-metabolic-bone-clinic-effect-of-age-and-vitamin-d-status
#4
J Mok, C Brown, A E B Moore, S S Min, G Hampson
PURPOSE: Teriparatide (TPD) is a skeletal anabolic agent used in patients with severe post-menopausal osteoporosis (PMO) and steroid-induced osteoporosis who are at hish risk of fracture. Predictors of therapeutic response to teriparatide in real-life setting are not well characterised. We investigated potential factors associated with teriparatide response in post-menopausal women with established osteoporosis. METHODS: We carried out a retrospective survey of 48 women, aged 73...
August 2018: Endocrine Research
https://www.readbyqxmd.com/read/29624091/excess-visceral-adiposity-is-associated-with-diabetic-retinopathy-in-a-multiethnic-asian-cohort-with-longstanding-type-2-diabetes
#5
Angela Moh, Kumari Neelam, Xiao Zhang, Chee Fang Sum, Subramaniam Tavintharan, Keven Ang, Simon Biing Ming Lee, Wern Ee Tang, Su Chi Lim
Purpose/Aim: Diabetic retinopathy (DR) is the most common diabetic microvascular complication, and it typically develops after 10 years of diabetes diagnosis. The primary aim of this study was to evaluate the association between adiposity and DR susceptibility among individuals with longstanding type 2 diabetes mellitus (T2D). MATERIALS AND METHODS: In this cross-sectional study, DR was assessed by fundus photography in 953 T2D subjects. DR prevalence by categories of T2D duration was evaluated...
August 2018: Endocrine Research
https://www.readbyqxmd.com/read/29578828/the-cellular-and-molecular-effects-of-the-androgen-receptor-agonist-cl-4as-1-on-breast-cancer-cells
#6
Mamoun Ahram, Ebtihal Mustafa, Shatha Abu Hammad, Mariam Alhudhud, Randa Bawadi, Lubna Tahtamouni, Faisal Khatib, Malek Zihlif
PURPOSE: The androgen receptor (AR) has attracted attention in the treatment of breast cancer. Due to the undesirable side effects of AR agonists, attempts have been undertaken to develop selective AR modulators. One of these compounds is Cl-4AS-1. This study examined this compound more closely at the cellular and molecular levels. METHODS: Three different breast cancer cell lines were utilized, namely the luminal MCF-7 cells, the molecular apocrine MDA-MB-453 cells, and the triple negative, basal MDA-MB-231 cells...
August 2018: Endocrine Research
https://www.readbyqxmd.com/read/29528762/modifications-in-the-spectrum-of-bone-mass-predictive-factors-with-menopausal-status
#7
Stefana Catalina Bilha, Dumitru Branisteanu, Catalin Buzduga, Daniela Constantinescu, Petru Cianga, Ecaterina Anisie, Cristina Gavrilovici, Adrian Covic, Maria Christina Ungureanu
PURPOSE: Fat mass (FM) is a source of adipocytokines, with both positive and negative bone consequences. We aimed to investigate the role of body composition and adipokines as predictive factors for bone mass in women. METHODOLOGY: This cross-sectional study included 93 women (38 premenopausal and 55 postmenopausal). Bone mineral density (BMD) and body composition were assessed by dual-energy X-ray absorptiometry. Serum levels of leptin, adiponectin, resistin, and also of the phosphocalcic markers parathormone and vitamin D were measured...
August 2018: Endocrine Research
https://www.readbyqxmd.com/read/29528756/vasoactive-androgens-vasorelaxing-effects-and-their-potential-regulation-of-blood-pressure
#8
Lucía Isidoro, Mercedes Ferrer, Mercedes Perusquía
BACKGROUND: Testosterone, 5α- and 5β-dihydrotestosterone (-DHT) induce an acute in vitro vasorelaxation and in vivo vasodepressor, hypotensive and antihypertensive responses. Our aim was to study whether androgen-induced blood pressure (BP) reduction is involved with a blockade of Ca2+ influx through L-type voltage-operated calcium channels (L-VOCCs) and/or the signaling pathways of α1 -adrenoceptors to induce vasoconstriction, which are one of the major mechanisms of BP maintenance...
August 2018: Endocrine Research
https://www.readbyqxmd.com/read/29521566/diabetic-serum-from-older-women-increases-adipogenic-differentiation-in-mesenchymal-stem-cells
#9
Kendall F Moseley, Máire E Doyle, Suzanne M Jan De Beur
BACKGROUND: Paradoxically, elderly persons with type 2 diabetes mellitus (T2DM) fracture despite having higher bone density than nondiabetics. Systemic factors associated with aging and T2DM may have detrimental, local effects on the skeleton. One such factor could be by altering the microenvironment of the mesenchymal stem cells (MSCs), multipotent progenitors capable of differentiating into adipocytes or osteoblasts. METHODS: Sera were obtained from four participant groups (n = 40 total, 10 per group): (1) young women with normal glucose tolerance (NGTY), (2) postmenopausal women with NGT), (3) postmenopausal women with impaired glucose tolerance (IGT), and (4) postmenopausal women with T2DM...
August 2018: Endocrine Research
https://www.readbyqxmd.com/read/29461127/mibi-scintigraphy-of-parathyroid-adenomas-correlation-with-biochemical-and-histological-markers
#10
Michael Cordes, Otto Dworak, Thomas Papadopoulos, Stephan Coerper, Torsten Kuwert
PURPOSE: In this study, we tested the hypothesis that MIBI-positive and MIBI-negative adenomas of parathyroid glands (APGs) have distinct biochemical and histological markers that could help differentiate MIBI-positive from MIBI-negative APGs. PATIENTS AND METHODS: 40 patients with 41 APGs were included in the study. Patients were enrolled in the study after MIBI scintigraphy examinations had been carried out. Biochemical analyses included serum levels of calcium (Ca), intact parathyroid hormone (iPTH), and 25-hydroxyvitamin D3 (25-OH-D3)...
August 2018: Endocrine Research
https://www.readbyqxmd.com/read/29451987/association-of-adiponectin-leptin-ratio-with-carbohydrate-and-lipid-metabolism-parameters-in-hiv-infected-patients-during-antiretroviral-therapy
#11
Catalin Tiliscan, Victoria Arama, Raluca Mihailescu, Daniela Munteanu, Diana Gabriela Iacob, Cristina Popescu, Remulus Catana, Anca Negru, Alina Lobodan, Stefan Sorin Arama
BACKGROUND: Adiponectin and leptin are adipose tissue hormones that regulate important lipid and glucose metabolic pathways. Our objective was to evaluate the interplay of these hormones described by the adiponectin/leptin ratio (ALR) in correlation to lipid and carbohydrate metabolism parameters in nondiabetic HIV-infected patients during antiretroviral therapy (ART). MATERIALS AND METHODS: We enrolled consecutive nondiabetic patients with confirmed HIV infection, undergoing stable ART regimens for at least six months...
August 2018: Endocrine Research
https://www.readbyqxmd.com/read/29877745/osteoprotegerin-increases-parallel-to-insulin-resistance-in-obese-adolescents
#12
Eleni P Kotanidou, Christos P Kotanidis, Styliani Giza, Anastasios Serbis, Vasiliki-Regina Tsinopoulou, Paraskevi Karalazou, Georgios Tzimagiorgis, Assimina Galli-Tsinopoulou
Purpose/Aim of the Study: Osteoprotegerin (OPG) is an α tumor necrosis factor receptor superfamily glucoprotein that acts as a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL), exerting an antiresoptive bone effect. It was recently shown that OPG/RANKL axis is activated during vascular calcification, contributing to atherosclerotic lesions formation. Additionally, OPG levels are charachterized as an independent risk factor for overall vascular mortality in obese adults. We aimed to investigate OPG levels in children/adolescents with obesity and explore possible relations with obesity-related insulin resistance (IR)...
June 7, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29787340/correlation-between-thyroidal-and-peripheral-blood-total-t-cells-cd8-t-cells-and-cd8-t-regulatory-cells-and-t-cell-reactivity-to-calsequestrin-and-collagen-xiii-in-patients-with-graves-ophthalmopathy
#13
Farah Al-Ansari, Hooshang Lahooti, Leanne Stokes, Senarath Edirimanne, Jack Wall
Purpose/aim of the study: Graves' ophthalmopathy (GO) is closely related to the thyroid autoimmune disorder Graves' disease. Previous studies have suggested roles for thyroidal CD8+  T cells and autoimmunity against calsequestrin-1 (CASQ)-1 in the link between thyroidal and orbital autoimmune reactions in GO. A role for autoimmunity against CollXIII has also been suggested. In this study, we aimed to investigate correlations between some thyroidal and peripheral blood T-cell subsets and thyroidal T-cell reactivity against CASQ1 and CollXIII in patients with GO...
May 22, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29781744/endurance-training-alters-ykl40-perm1-and-hsp70-skeletal-muscle-protein-contents-in-men-with-type-2-diabetes-mellitus
#14
Christian Brinkmann, Anika Kuckertz, Thorsten Schiffer, Wilhelm Bloch, Hans-Georg Predel, Klara Brixius
BACKGROUND: The fight against type 2 diabetes mellitus (T2DM) is tremendously challenging. This pilot study investigates whether endurance training (3 times per week for 3 months, moderate intensity) can change the skeletal muscle protein contents of chitinase-3-like protein-1 (YKL40), peroxisome proliferator-activated receptor y coactivator-1 and estrogen-related receptor-induced regulator in muscle-1 (PERM1) and heat-shock protein-70 (HSP70), which have been discussed as novel therapeutically relevant targets...
May 21, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29768065/fibroblast-growth-factor-21-adiposity-and-macronutrient-balance-in-a-healthy-pregnant-population-with-overweight-and-obesity
#15
Elizabeth F Sutton, Christopher D Morrison, Jacqueline M Stephens, Leanne M Redman
AIM OF THE STUDY: The regulation and actions of fibroblast growth factor 21 (FGF21) are responsive to energy status and macronutrient balance, and investigations of FGF21 in normal pregnancy, which could be informative for FGF21 biology, are seldom. The goal of our study was to examine FGF21 levels in a contemporary healthy, pregnant population. METHODS: We phenotyped 43 women with overweight and obesity during pregnancy for weight, body composition, and fasting blood...
May 16, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29733702/a-new-type-of-familial-partial-lipodystrophy-distinctive-fat-distribution-and-proteinuria
#16
Banu Yurekli, Nilufer Ozdemir Kutbay, Canan Altay, Sadiye Mehtat Unlu, Sait Sen, Huseyin Onay, Tahir Atik, Baris Akinci
PURPOSE: To describe an interesting subtype of familial partial lipodystrophy (FPLD). METHODS: The phenotype of this distinctive FPLD subtype was studied in three Turkish female siblings. RESULTS: Mutation testing was negative for the genes associated with lipodystrophy syndromes. In MRI studies, fat loss was prominent in the posterior aspects of the proximal lower limbs, whilst some fat was preserved in the anterior, medial and lateral aspects...
May 7, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29733698/age-associated-increase-of-thyroid-hormone-receptor-%C3%AE-gene-promoter-methylation-coexists-with-decreased-gene-expression
#17
Eliza Pawlik-Pachucka, Monika Budzinska, Zofia Wicik, Anna Domaszewska-Szostek, Magdalena Owczarz, Malgorzata Roszkowska-Gancarz, Magdalena Gewartowska, Monika Puzianowska-Kuznicka
PURPOSE: It is not established if healthy aging of the thyroid axis is associated with alterations other than changes in hormone secretion. METHODS: The expression of thyroid hormone receptor β gene (THRB) was analyzed in peripheral blood mononuclear cells (PBMC) obtained from young, elderly, and long-lived individuals. The interaction between the 3'UTR of TRβ1 mRNA and selected miRNAs was measured using pmirGLO reporter vector. Methylation of the THRB CpG island was analyzed using methylation-sensitive restriction/RT-PCR and bisulfite sequencing methods...
May 7, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29400579/occult-urolithiasis-in-asymptomatic-primary-hyperparathyroidism
#18
Yu-Kwang Donovan Tay, Minghao Liu, Leonardo Bandeira, Mariana Bucovsky, James A Lee, Shonni J Silverberg, Marcella D Walker
OBJECTIVE: Recent international guidelines suggest renal imaging to detect occult urolithiasis in all patients with asymptomatic primary hyperparathyroidism (PHPT), but data regarding their prevalence and associated risk factors are limited. We evaluated the prevalence and risk factors for occult urolithiasis. METHODS: Cross-sectional analysis of 96 asymptomatic PHPT patients from a university hospital in the United States with and without occult nephrolithiasis...
May 2018: Endocrine Research
https://www.readbyqxmd.com/read/29381079/impact-of-admission-serum-calcium-levels-on-mortality-in-hospitalized-patients
#19
Wisit Cheungpasitporn, Charat Thongprayoon, Michael A Mao, Wonngarm Kittanamongkolchai, Ankit Sakhuja, Stephen B Erickson
OBJECTIVES: To assess the relationship between admission serum calcium levels and in-hospital mortality in all hospitalized patients. METHODS: All adult hospitalized patients who had admission serum calcium levels available between years 2009 and 2013 were enrolled. Admission serum calcium was categorized based on its distribution into six groups (<7.9, 7.9 to <8.4, 8.4 to <9.0, 9.0 to <9.6, 9.6 to <10.1, and ≥10.1 mg/dL). The odds ratio (OR) of in-hospital mortality by admission serum calcium, using the calcium category of 9...
May 2018: Endocrine Research
https://www.readbyqxmd.com/read/29319359/secondary-and-tertiary-preventions-of-thyroid-disease
#20
Fereidoun Azizi, Ladan Mehran, Farhad Hosseinpanah, Hossein Delshad, Atieh Amouzegar
INTRODUCTION: Secondary and tertiary preventions are concerned with the recognition of the disease process in a very early stage and delay in progression to complete disease and minimization of complications and the impact of illness. METHODS: All articles related to secondary and tertiary prevention of thyroid diseases were reviewed. Using related key words, articles published between 2001 and 2015 were evaluated, categorized, and analyzed. RESULTS: In secondary prevention, congenital hypothyroidism and subclinical hypo and hyperthyroidism are equally important...
May 2018: Endocrine Research
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