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Vaccine

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https://www.readbyqxmd.com/read/30017148/dual-route-vaccination-for-plague-with-emergency-use-applications
#1
B D Moore, R R C New, W Butcher, R Mahood, J Steward, M Bayliss, C MacLeod, M Bogus, E D Williamson
Here, we report a dual-route vaccination approach for plague, able to induce a rapid response involving systemic and mucosal immunity, whilst also providing ease of use in those resource-poor settings most vulnerable to disease outbreaks. This novel vaccine (VypVaxDuo) comprises the recombinant F1 and V proteins in free association. VypVaxDuo has been designed for administration via a sub-cutaneous priming dose followed by a single oral booster dose and has been demonstrated to induce early onset immunity 14 days after the primary immunisation; full protective efficacy against live organism challenge was achieved in Balb/c mice exposed to 2 × 104 median lethal doses of Yersinia pestis Co92, by the sub-cutaneous route at 25 days after the oral booster immunisation...
July 14, 2018: Vaccine
https://www.readbyqxmd.com/read/30017147/immunization-regimen-in-asian-sea-bass-lates-calcarifer-broodfish-a-practical-strategy-to-control-vertical-transmission-of-nervous-necrosis-virus-during-seed-production
#2
Rolando Pakingking, Evelyn Grace de Jesus-Ayson, Ofelia Reyes, Norwell Brian Bautista
Outbreaks of viral nervous necrosis (VNN) in Asian sea bass (Lates calcarifer) at the larval stages via vertical transmission of nervous necrosis virus (NNV) from asymptomatic broodfish remain as a major deterrent during seed production. A five-year study was conducted to produce NNV-specific-free sea bass broodfish reared in land-based tanks through an annual immunization regimen with the formalin-inactivated NNV. We primarily immunized (intraperitoneal injection) sea bass juveniles (5 g) and monitored the neutralizing antibody (Nab) titers in the sera of these fish at scheduled intervals post-immunization...
July 14, 2018: Vaccine
https://www.readbyqxmd.com/read/30017146/cost-effectiveness-of-sex-neutral-hpv-vaccination-in-sweden-accounting-for-herd-immunity-and-sexual-behaviour
#3
Ellen Wolff, K Miriam Elfström, Hedda Haugen Cange, Sofie Larsson, Helene Englund, Pär Sparén, Adam Roth
INTRODUCTION: The aim was to assess cost-effectiveness of expanding the Swedish HPV-vaccination program to include preadolescent boys, by comparing health-effects and costs of HPV-related disease, with a sex-neutral vaccination program versus only vaccinating girls. METHODS: We used a dynamic compartmental model to simulate the burden of HPV16/18-related disease in Sweden, accounting for indirect effects of vaccination through herd-immunity. The model accounted for sexual behaviour, such as age preferences and men who have sex with men...
July 14, 2018: Vaccine
https://www.readbyqxmd.com/read/30017144/the-2015-2016-influenza-epidemic-in-beijing-china-unlike-elsewhere-circulation-of-influenza-a-h3n2-with-moderate-vaccine-effectiveness
#4
Li Zhang, Yang Pan, Volker Hackert, Wim van der Hoek, Adam Meijer, Thomas Krafft, Peng Yang, Quanyi Wang
BACKGROUND: While the 2015-2016 influenza season in the northern hemisphere was dominated by A(H1N1)pdm09 and B/Victoria viruses, in Beijing, China, there was also significant circulation of influenza A(H3N2) virus. In this report we estimate vaccine effectiveness (VE) against influenza A(H3N2) and other circulating viruses, and describe further characteristics of the 2015-2016 influenza season in Beijing. METHODS: We estimated VE of the 2015-2016 trivalent inactivated vaccine (TIV) against laboratory-confirmed influenza virus infection using the test-negative study design...
July 14, 2018: Vaccine
https://www.readbyqxmd.com/read/30017145/cost-effectiveness-of-an-adjuvanted-recombinant-zoster-vaccine-in-older-adults-in-the-united-states
#5
D Curran, B Patterson, L Varghese, D Van Oorschot, P Buck, J Carrico, K Hicks, B Lee, B Yawn
In the United States, herpes zoster (HZ) and related complications are estimated to result in approximately $1.3 billion in medical care costs and $1.7 billion in indirect costs annually. In this study, we compared the cost-effectiveness of a new Adjuvanted Recombinant Zoster Vaccine (RZV), containing recombinant varicella-zoster virus glycoprotein E and the AS01B Adjuvant System, versus No Vaccine, as well as versus the live attenuated HZ vaccine (Zoster Vaccine Live (ZVL)) in subjects aged 60+ years of age (YOA) and other age cohorts aged 50+ YOA...
July 13, 2018: Vaccine
https://www.readbyqxmd.com/read/30017143/regulated-delayed-attenuation-enhances-the-immunogenicity-and-protection-provided-by-recombinant-salmonellaenterica-serovar-typhimurium-vaccines-expressing-serovar-choleraesuis-o-polysaccharides
#6
Xinxin Zhao, Sheng Liang, Qinlong Dai, Renyong Jia, Dekang Zhu, Mafeng Liu, Mingshu Wang, Shun Chen, Qiao Yang, Ying Wu, Shaqiu Zhang, Ling Zhang, Yunya Liu, Yanling Yu, Anchun Cheng
Regulated delayed attenuation is a well-studied strategy for retaining the immunogenicity of Salmonella-vectored vaccines. In this study, this strategy was used to optimize two previously constructed recombinant Salmonella enterica serovar Typhimurium vaccines expressing S. Choleraesuis O-polysaccharides (OPS). The novel vaccine strains SLT31 (Δasd ΔrmlB-rfbP ΔPcrp ::T araC PBAD ) and SLT33 (Δasd ΔrfbP ΔpagL::T araC PBAD rfbP ΔPcrp ::T araC PBAD ) were constructed by replacement of the native crp promoter with the arabinose-dependent araC PBAD promoter...
July 12, 2018: Vaccine
https://www.readbyqxmd.com/read/30017142/chitosan-alginate-microparticles-for-the-oral-delivery-of-fowl-typhoid-vaccine-innate-and-acquired-immunity
#7
Ebele Onuigbo, Joy Iseghohimhen, Kennedy Chah, Moses Gyang, Anthony Attama
Oral fowl typhoid (FT) vaccine is necessary for improved flock vaccinations and economic growth. This study was undertaken to evaluate the immune responses of birds given oral fowl typhoid vaccine coated with chitosan/alginate microparticles and comparing it with the conventional subcutaneous route of administration. Preliminary studies were done to evaluate the particle size, encapsulation efficiency and agglutination. Sixty day-old chicks were divided into three groups of twenty birds each. This comprised a negative control group NEG 451 (non-vaccinated and non-challenged used as control for cytokine quantification), SC 634 (live 9R vaccine by the injection route) and OCV 567 (live 9R vaccine coated with chitosan/alginate microparticles)...
July 12, 2018: Vaccine
https://www.readbyqxmd.com/read/30007826/effects-of-geographic-and-economic-heterogeneity-on-the-burden-of-rotavirus-diarrhea-and-the-impact-and-cost-effectiveness-of-vaccination-in-pakistan
#8
Richard Rheingans, John D Anderson, Karoun H Bagamian, Lindsey A Laytner, Clinton J Pecenka, Syed Saqlain Ahmad Gilani, Munir Ahmed
Globally, rotavirus is a leading cause of childhood diarrhea and related mortality. Although rotavirus vaccination has been introduced in many countries worldwide, there are numerous low- to middle-income countries that have not yet introduced. Pakistan is one of the countries with the highest number of rotavirus deaths in children under five years. Although rotavirus infection is almost universal among children, mortality is often a result of poor nutrition and lack of access to health care and other aspects of poverty...
July 12, 2018: Vaccine
https://www.readbyqxmd.com/read/30007825/novel-influenza-vaccine-m2sr-protects-against-drifted-h1n1-and-h3n2-influenza-virus-challenge-in-ferrets-with-pre-existing-immunity
#9
Yasuko Hatta, David Boltz, Sally Sarawar, Yoshihiro Kawaoka, Gabriele Neumann, Pamuk Bilsel
Current influenza vaccines do not provide effective protection against heterologous influenza viruses. The ability of the novel M2SR influenza vaccine to protect against drifted influenza viruses was evaluated in naïve ferrets and in ferrets with pre-existing immunity to influenza. In naïve ferrets, M2SR provided similar protection against drifted challenge viruses as the comparator vaccine, FluMist®. However, in ferrets with pre-existing immunity, M2SR provided superior protection than FluMist in two model systems...
July 12, 2018: Vaccine
https://www.readbyqxmd.com/read/30007827/effects-of-geographic-and-economic-heterogeneity-on-rotavirus-diarrhea-burden-and-vaccination-impact-and-cost-effectiveness-in-the-lao-people-s-democratic-republic
#10
Richard Rheingans, John D Anderson, Karoun H Bagamian, Clinton J Pecenka
Rotavirus enteritis is responsible for nearly 200,000 child deaths worldwide in 2015. Globally, many low- and middle-income countries have introduced rotavirus vaccine, resulting in documented reductions in hospitalizations and child mortality. We examined the potential impact and cost-effectiveness of introducing rotavirus vaccination in Lao People's Democratic Republic using an Excel-based spreadsheet model. We estimated mortality risk factors, patterns of care seeking, and vaccination access to predict outcomes for regional, provincial, and socioeconomic subpopulations for one birth cohort through their first five years of life and life course in Disability-Adjusted Life Years estimates...
July 11, 2018: Vaccine
https://www.readbyqxmd.com/read/30007824/visual-vaccinology-changing-public-perception
#11
Dominik Dunsch, Sabine Wicker
No abstract text is available yet for this article.
July 11, 2018: Vaccine
https://www.readbyqxmd.com/read/30005948/safety-and-immunogenicity-of-the-cuban-heptavalent-pneumococcal-conjugate-vaccine-in-healthy-infants-results-from-a-double-blind-randomized-control-trial-phase-i
#12
Carlos P Dotres Martínez, Nivaldo Linares-Pérez, María E Toledo-Romaní, Yarisset Ricardo Delgado, Rinaldo Puga Gómez, Beatriz Paredes Moreno, Laura M Rodriguez-Noda, Mayelín Mirabal Sosa, Darielys Santana Mederos, Dagmar García-Rivera, Yury Valdés-Balbín, David Goldblatt, Vicente Vérez-Bencomo
BACKGROUND: Cuba has a new pneumococcal conjugate vaccine candidate (PCV7-TT). This study evaluates the safety and immunogenicity in healthy infants using 2p+1 vaccination schedule. METHODS: A phase I, controlled, randomized and double blind clinical trial was designed. 30 unvaccinated healthy infants were included. 20 subjects were assigned to study group (PCV7-TT) and 10 to control group (Synflorix®) to receive the vaccines at 7, 8 months of age (primary series) and 11 months (booster dose)...
July 10, 2018: Vaccine
https://www.readbyqxmd.com/read/30005947/mixing-is-required-for-uniform-reconstitution-of-filter-dried-protein-antigens-in-a-single-injection-vaccine-formulation
#13
Napawan Thangsupanimitchai, Alexander D Edwards
Ambient temperature filter dried vaccine formulations have been proposed to simultaneously achieve thermostability and offer a ready-to-use immunisation device that combines reconstitution and injection. Vaccine concentration should be uniform at the point of injection, but the uniformity following direct reconstitution of filter-dried vaccines has not been reported. We present here a study of vaccine mixing and release following dissolution of filter-dried model protein and toxoid antigens within a single syringe, filter and needle unit...
July 10, 2018: Vaccine
https://www.readbyqxmd.com/read/30005946/in-vivo-and-in-vitro-immunogenicity-of-novel-mhc-class-i-presented-epitopes-to-confer-protective-immunity-against-chronic-htlv-1-infection
#14
Ria Mulherkar, Aykan Karabudak, Rashida Ginwala, Xiaofang Huang, Aileen Rowan, Ramila Philip, Edward L Murphy, Danielle Clements, Lishomwa C Ndhlovu, Zafar K Khan, Pooja Jain
Human T-cell leukemia virus type 1 (HTLV-1) has infected as many as 10 million people worldwide. While 90% are asymptomatic, 5% develop severe diseases including adult T-cell leukemia/lymphoka (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). No vaccine against HTLV-1 exists, and screening programs are not universal. However, patients with chronic HTLV-1 infection have high frequencies of HTLV-1-activated CD8+ T cells, and the two main HLA alleles (A2, A24) are present in 88% of infected individuals...
July 10, 2018: Vaccine
https://www.readbyqxmd.com/read/30005949/streptococcus-pneumoniae-serotype-19a-in-latin-america-and-the-caribbean-2010-2015-a-systematic-review-and-a-time-series-analysis
#15
Clara Inés Agudelo, Rodrigo DeAntonio, Elizabeth Castañeda
BACKGROUND: This systematic review aims to describe the prevalence, trends, and antibiotic resistance of Streptococcus pneumoniae serotype 19A (Spn19A) that causes invasive and non-invasive diseases in children <5 years in Latin-American and Caribbean countries. METHODS: We searched for published (between January 2010 and February 2016) observational and clinical studies within the region including effectiveness and impact on Spn19A after pneumococcal conjugate vaccine (PCV) introduction...
July 6, 2018: Vaccine
https://www.readbyqxmd.com/read/29997035/spatial-and-temporal-risk-as-drivers-for-adoption-of-foot-and-mouth-disease-vaccination
#16
Ashley F Railey, Tiziana Lembo, Guy H Palmer, Gabriel M Shirima, Thomas L Marsh
Identifying the drivers of vaccine adoption decisions under varying levels of perceived disease risk and benefit provides insight into what can limit or enhance vaccination uptake. To address the relationship of perceived benefit relative to temporal and spatial risk, we surveyed 432 pastoralist households in northern Tanzania on vaccination for foot-and-mouth disease (FMD). Unlike human health vaccination decisions where beliefs regarding adverse, personal health effects factor heavily into perceived risk, decisions for animal vaccination focus disproportionately on dynamic risks to animal productivity...
July 6, 2018: Vaccine
https://www.readbyqxmd.com/read/29983258/national-cervical-cancer-prevention-program-in-the-arab-states-strategies-and-cost-minimization-study-of-the-tunisian-case
#17
R Gamaoun
BACKGROUND: The Arab states geographic region is marked by a low to moderate cervical cancer screening coverage rates and the absence of national human papillomavirus (HPV) vaccination programs, except for the United Arab Emirates. Knowing that the HPV prevalence among Tunisian woman is estimated to 4.9/100 000 according to the "HPV Center" data, this study aims to estimate the cost of a national cervical cancer prevention program in Tunisia using either the primary prevention method (the two-dose schedule anti-HPV vaccine according to the WHO recommendation for young adolescents) or the secondary prevention method (the Pap smear test according to three time-lapse periodicity)...
July 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29983257/an-environmental-scan-to-examine-stakeholder-perspectives-on-human-papillomavirus-vaccination-a-mixed-methods-study
#18
B A Paige Lake, Monica L Kasting, Teri Malo, Anna R Giuliano, Susan T Vadaparampil
PURPOSE: Human papillomavirus (HPV) vaccine series completion rates among females and males remain low in Florida (46.4% and 34.5%, respectively). Multiple stakeholders influence vaccination uptake, including health care providers (HCPs), public health professionals (PHPs), and members of professional organizations. We examined stakeholder efforts related to increasing vaccine uptake and education among parents/adolescents and HCPs. METHODS: We conducted an environmental scan of stakeholder efforts and identified stakeholders using our professional networks and a snowball sampling approach...
July 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29983256/response-to-pneumococcal-vaccine-in-interstitial-lung-disease-patients-influence-of-systemic-immunosuppressive-treatment
#19
Koji Kuronuma, Hiroyuki Honda, Tessei Mikami, Atsushi Saito, Kimiyuki Ikeda, Mitsuo Otsuka, Hirofumi Chiba, Gen Yamada, Toyotaka Sato, Shin-Ichi Yokota, Hiroki Takahashi
BACKGROUND: Interstitial lung diseases (ILD) are severe respiratory diseases, and ILD patients are treated with corticosteroid and immunosuppressive agents. However, it is unclear whether these medications influence the response of pneumococcal vaccine. OBJECTIVES: We examined the immunogenicity of pneumococcal vaccines (PPSV23 and PCV13) in ILD patients undergoing immunosuppressive treatment. METHODS: ILD patients who were regularly followed at the outpatient clinic were enrolled...
July 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29983255/the-use-of-ehealth-with-immunizations-an-overview-of-systematic-reviews
#20
REVIEW
Elsy Maria Dumit, David Novillo-Ortiz, Marcela Contreras, Martha Velandia, M Carolina Danovaro-Holliday
BACKGROUND: eHealth interventions may help increase vaccination uptake and health literacy related to immunization and improve immunization program efficiency. OBJECTIVES: To see where and how eHealth technologies have had a positive impact on immunization practices-using eHealth strategies to increase vaccination uptake, improve immunization program efficiency and advance heath literacy related to immunizations. METHODS: An overview of systematic reviews was conducted, searching PubMed, Scopus, Embase, and Web of Science for systematic reviews published through August 2017 for eHealth and immunizations (using pre-determined concepts for each)...
July 5, 2018: Vaccine
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