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https://www.readbyqxmd.com/read/29331246/estimation-of-expected-dengue-seroprevalence-from-passive-epidemiological-surveillance-systems-in-selected-areas-of-argentina-a-proxy-to-evaluate-the-applicability-of-dengue-vaccination
#1
Pablo Orellano, Darío Vezzani, Nancy Quaranta, Julieta Reynoso, Oscar Daniel Salomón
BACKGROUND: Current recommendations about dengue vaccination by the World Health Organization depend on seroprevalence levels and serological status in populations and individuals. However, seroprevalence estimation may be difficult due to a diversity of factors. Thus, estimation through models using data from epidemiological surveillance systems could be an alternative procedure to achieve this goal. OBJECTIVE: To estimate the expected dengue seroprevalence in children of selected areas in Argentina, using a simple model based on data from passive epidemiological surveillance systems...
January 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29331245/outsmart-hpv-acceptability-and-short-term-effects-of-a-web-based-hpv-vaccination-intervention-for-young-adult-gay-and-bisexual-men
#2
Annie-Laurie McRee, Abigail Shoben, Jose A Bauermeister, Mira L Katz, Electra D Paskett, Paul L Reiter
BACKGROUND: Effective interventions to promote human papillomavirus (HPV) vaccination are needed, particularly among populations at increased risk of HPV-related disease. We developed and pilot tested a web-based intervention, Outsmart HPV, to promote HPV vaccination among young gay and bisexual men (YGBM). METHODS: In 2016, we recruited a national sample (n = 150) of YGBM ages 18-25 in the United States who had not received any doses of HPV vaccine. Participants were randomized to receive either standard HPV vaccination information (control) or population-targeted, individually-tailored content (Outsmart HPV intervention)...
January 10, 2018: Vaccine
https://www.readbyqxmd.com/read/29329685/association-of-provider-recommendation-and-offer-and-influenza-vaccination-among-adults-aged-%C3%A2-18%C3%A2-years-united-states
#3
Peng-Jun Lu, Anup Srivastav, Ashley Amaya, Jill A Dever, Jessica Roycroft, Marshica Stanley Kurtz, Alissa O'Halloran, Walter W Williams
BACKGROUND: Influenza vaccination has been recommended for all persons aged ≥6 months since 2010. METHODS: Data from the 2016 National Internet Flu Survey were analyzed to assess provider vaccination recommendations and early influenza vaccination during the 2016-17 season among adults aged ≥18 years. Predictive marginals from a multivariable logistic regression model were used to identify factors independently associated with early vaccine uptake by provider vaccination recommendation status...
January 9, 2018: Vaccine
https://www.readbyqxmd.com/read/29329684/impact-of-seasonal-influenza-vaccination-in-the-presence-of-vaccine-interference
#4
Eunha Shim, Kenneth J Smith, Mary Patricia Nowalk, Jonathan M Raviotta, Shawn T Brown, Jay DePasse, Richard K Zimmerman
BACKGROUND: Annual influenza vaccination is a key to preventing widespread influenza infections. Recent reports of influenza vaccine effectiveness (VE) indicate that vaccination in prior years may reduce VE in the current season, suggesting vaccine interference. The purpose of this study is to evaluate the potential effect of repeat influenza vaccinations in the presence of vaccine interference. METHODS: Using literature-based parameters, an age-structured influenza equation-based transmission model was used to determine the optimal vaccination strategy, while considering the effect of varying levels of interference...
January 9, 2018: Vaccine
https://www.readbyqxmd.com/read/29325822/parental-vaccine-hesitancy-in-italy-results-from-a-national-survey
#5
Cristina Giambi, Massimo Fabiani, Fortunato D'Ancona, Lorenza Ferrara, Daniel Fiacchini, Tolinda Gallo, Domenico Martinelli, Maria Grazia Pascucci, Rosa Prato, Antonietta Filia, Antonino Bella, Martina Del Manso, Caterina Rizzo, Maria Cristina Rota
In Italy, in 2016, we conducted a cross-sectional survey to estimate vaccine hesitancy and investigate its determinants among parents of children aged 16-36 months. Data on parental attitudes and beliefs about vaccinations were collected through a questionnaire administered online or self-administered at pediatricians' offices and nurseries. Parents were classified as pro-vaccine, vaccine-hesitant or anti-vaccine, according to self-reported tetanus and measles vaccination status of their child. Multivariable logistic regression was used to investigate factors associated with hesitancy...
January 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29325821/dna-vaccine-encoding-myristoylated-membrane-protein-mmp-of-rock-bream-iridovirus-rbiv-induces-protective-immunity-in-rock-bream-oplegnathus-fasciatus
#6
Myung-Hwa Jung, Chamilani Nikapitiya, Sung-Ju Jung
Rock bream iridovirus (RBIV) causes severe mass mortalities in rock bream (Oplegnathus fasciatus) in Korea. In this study, we investigated the potential of viral membrane protein to induce antiviral status protecting rock bream against RBIV infection. We found that fish administered with ORF008L (myristoylated membrane protein, MMP) vaccine exhibited significantly higher levels of survival compared to ORF007L (major capsid protein, MCP). Moreover, ORF008L-based DNA vaccinated fish showed significant protection at 4 and 8 weeks post vaccination (wpv) than non-vaccinated fish after infected with RBIV (6...
January 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29325820/an-assessment-of-shedding-with-the-oral-rabies-virus-vaccine-strain-spbn-gasgas-in-target-and-non-target-species
#7
Ad Vos, Conrad Freuling, Steffen Ortmann, Antje Kretzschmar, Dietmar Mayer, Annette Schliephake, Thomas Müller
A safety requirement for live vaccines is investigating possible shedding in recipients since the presence of replication competent vaccine in secretions could result in direct and indirect horizontal transmission. This is especially relevant for oral rabies vaccine baits that are deliberately distributed into the environment. In the current study, survival of an oral rabies virus vaccine, SPBN GASGAS, was examined in excretions from different target and non-target species; red fox, raccoon dog, small Indian mongoose, raccoon, striped skunk, domestic dog, domestic cat and domestic pig...
January 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29325819/explanations-for-the-high-potency-of-hpv-prophylactic-vaccines
#8
John Schiller, Doug Lowy
HPV L1 virus-like particle (VLP) vaccines administered in a prime/boost series of three injections over six months have demonstrated remarkable prophylactic efficacy in clinical trials and effectiveness in national immunization programs with high rates of coverage. There is mounting evidence that the vaccines have similar efficacy and effectiveness even when administered in a single dose. The unexpected potency of one dose of these VLP vaccines may largely be attributed to structural features of the particles, which lead to the efficient generation of long-lived antigen-specific antibody-producing cells and unique features of the virus life cycle that make the HPV virions highly susceptible to antibody-mediated inhibition of infection...
January 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29317118/safety-and-immunogenicity-of-single-dose-live-oral-cholera-vaccine-strain-cvd-103-hgr-in-healthy-adults-age-18-45
#9
James M McCarty, Michael D Lock, Kristin M Hunt, Jakub K Simon, Marc Gurwith
The attenuated recombinant Vibrio cholerae O1 vaccine strain CVD 103-HgR, re-developed as PXVX0200, elicits a rapid serum vibriocidal antibody (SVA) response and protects against cholera diarrhea in volunteer challenge studies. We performed a phase 3, placebo controlled, double blind, multi-center study to further assess the safety, immunogenicity, and lot-to-lot consistency of PXVX0200. Adult volunteers 18-45 years of age were randomized 8:1 to receive a single dose of 1 × 109 CFU of PXVX0200 from three production lots or saline placebo...
January 6, 2018: Vaccine
https://www.readbyqxmd.com/read/29317117/measles-mumps-and-rubella-antibody-patterns-of-persistence-and-rate-of-decline-following-the-second-dose-of-the-mmr-vaccine
#10
Emma E Seagle, Robert A Bednarczyk, Tenisha Hill, Amy Parker Fiebelkorn, Carole J Hickman, Joseph P Icenogle, Edward A Belongia, Huong Q McLean
BACKGROUND: Antibodies to measles, mumps, and rubella decline 3% per year on average, and have a high degree of individual variation. Yet, individual variations and differences across antigens are not well understood. To better understand potential implications on individual and population susceptibility, we reanalyzed longitudinal data to identify patterns of seropositivity and persistence. METHODS: Children vaccinated with the second dose of measles, mumps, rubella vaccine (MMR2) at 4-6 years of age were followed up to 12 years post-vaccination...
January 6, 2018: Vaccine
https://www.readbyqxmd.com/read/29310901/why-do-we-not-want-to-recommend-influenza-vaccination-to-young-children-a-qualitative-study-of-australian-parents-and-primary-care-providers
#11
Ruby Biezen, Danilla Grando, Danielle Mazza, Bianca Brijnath
INTRODUCTION: Influenza vaccination has been shown to be safe and effective against influenza and in the prevention of complicating secondary respiratory illnesses. However, its uptake in young children remains low. This study explored the views, attitudes and practices of parents and primary care providers (PCPs) on their knowledge and acceptance of influenza vaccination in children under 5. METHODS: Using a cross-sectional qualitative research design, we conducted 30 in-depth interviews with PCPs (i...
January 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29310900/immunogenicity-and-protective-efficacy-of-an-inactivated-cell-culture-derived-seneca-valley-virus-vaccine-in-pigs
#12
Fan Yang, Zixiang Zhu, Weijun Cao, Huanan Liu, Keshan Zhang, Hong Tian, Xiangtao Liu, Haixue Zheng
Seneca Valley virus (SVV) infection in pigs is associated with porcine idiopathic vesicular disease (PIVD). Outbreaks of SVV infection in pig herds have been reported in several Asia and Americas countries. Recently, a series of outbreaks of SVV infection occurred in China, Canada, Thailand and the United States. However, no available vaccines have been developed to limit the transmission of SVV. The SVV CH-FJ-2017 from Fujian province in China is a representative of the epidemic strains, and shows 98.5-99...
January 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29307477/enhancing-toxin-based-vaccines-against-botulism
#13
Amanda Przedpelski, William H Tepp, Madison Zuverink, Eric A Johnson, Sabine Pellet, Joseph T Barbieri
Botulinum neurotoxins (BoNT) are the most toxic proteins for humans. BoNTs are single chain proteins with an N-terminal light chain (LC) and a C-terminal heavy chain (HC). HC comprises a translocation domain (HCN) and a receptor binding domain (HCC). Currently, there are no approved vaccines against botulism. This study tests a recombinant, full-length BoNT/A1 versus LCHCN/A1 and HCC/A1 as vaccine candidates against botulism. Recombinant, full-length BoNT/A1 was detoxified by engineering 3-amino acid mutations (E224A/R363A/Y366F) (M-BoNT/A1) into the LC to eliminate catalytic activity, which reduced toxicity in a mouse model of botulism by >106-fold relative to native BoNT/A1...
January 4, 2018: Vaccine
https://www.readbyqxmd.com/read/29307476/occurrence-of-home-based-record-stock-outs-a-quiet-problem-for-national-immunization-programmes-continues
#14
David W Brown, Marta Gacic-Dobo
Home-based records (HBRs) provide an effective, inexpensive mechanism for recording and tracking infant vaccinations, yet stock-outs prevent HBRs from fulfilling their intended function. We describe the annual occurrence of HBR stock-outs during 2014-2016 reported by national immunization programmes to the WHO and UNICEF on the Joint Reporting Form on Immunization. During 2014-16, 48 countries reported at least one HBR stock-out. Thirteen countries reported HBR stock-outs for two of the three years. Forty-four countries reported two or more HBR funding sources in 2016...
January 4, 2018: Vaccine
https://www.readbyqxmd.com/read/29306509/the-associations-between-medical-allied-and-complementary-medicine-practitioner-visits-and-childhood-vaccine-uptake
#15
Jane E Frawley, Hope Foley, Erica McIntyre
BACKGROUND: Vaccination rates have remained steady for a number of years in Australia, however geographical areas of lower vaccine coverage remains a day-to-day challenge. The study explores parental attitudes, beliefs and intentions in relation to vaccination and examines the early effects of recent No Jab No Pay legislation. METHODS: A national survey of was conducted, using an online questionnaire. Parents from all states in Australia with at least one child aged <6 years were invited to participate...
January 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29306508/a-virus-like-particle-vaccine-candidate-for-influenza-a-virus-based-on-multiple-conserved-antigens-presented-on-hepatitis-b-tandem-core-particles
#16
Alejandro Ramirez, Stephen Morris, Sophie Maucourant, Isabella D'Ascanio, Vincenzo Crescente, I-Na Lu, Sophie Farinelle, Claude P Muller, Michael Whelan, William Rosenberg
Existing Influenza A virus (IAV) vaccines target variable parts of the virus that may change between seasons. Vaccine design relies on predicting the predominant circulating influenza strains but when there is a mismatch between vaccine and circulating strains, efficacy is sub-optimal. Furthermore, current approaches provide limited protection against emerging influenza strains that may cause pandemics. One solution is to design vaccines that target conserved protein domains of influenza, which remain largely unchanged over time and are likely to be found in emergent variants...
January 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29306507/immunogenicity-and-safety-of-a-novel-tetanus-toxoid-conjugated-anti-gastrin-vaccine-in-balb-c-mice
#17
Qing He, Hua Gao, Meng Gao, Shengmei Qi, Kun Yang, Yingqi Zhang, Junzhi Wang
The objective of this study is to determine the immunogenicity and safety of our novel anti-gastrin vaccine that is composed of the common amino-terminal portions of human carboxy-amidated gastrin-17 (G17) and glycine-extended gastrin-17 (gly-G17) as well as the common carboxy-terminal portion of the gastrin precursor progastrin (in a 50:50 mixture) all covalently linked to tetanus toxoid (TT) via peptide spacers. The vaccine, or immunogen, was injected intramuscularly into the legs of BALB/c mice, which produced high serum titres of specific IgG antibodies and IFN-γ in their spleen cells, identifiable by enzyme-linked immunosorbent assay (ELISA) and enzyme-linked immunospot assay (ELISPOT), respectively...
January 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29306506/antibody-responses-among-adolescent-females-receiving-two-or-three-quadrivalent-human-papillomavirus-vaccine-doses-at-standard-and-prolonged-intervals
#18
Lea E Widdice, Elizabeth R Unger, Gitika Panicker, Rebecca Hoagland, S Todd Callahan, Lisa A Jackson, Andrea A Berry, Karen Kotloff, Sharon E Frey, Christopher J Harrison, Barbara A Pahud, Kathryn M Edwards, Mark J Mulligan, Jon Sudman, David I Bernstein
BACKGROUND: The originally recommended dosing schedule, 0, 2, 6 months, for the 3-dose quadrivalent human papillomavirus vaccine (4vHPV) was often not followed, resulting in longer than recommended intervals between doses and interest in the effect of prolonged intervals. Recent two-dose recommendations require investigations into the effect of delaying dose 2. METHODS: This multi-site, prospective study enrolled healthy 9-17 year old girls (n = 1321) on the day of or within 28 days following a third dose of 4vHPV vaccination...
January 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29306505/igg-antibody-prevalence-suggests-high-immunization-needs-in-newcomers-to-luxembourg-2012
#19
Judith M Hübschen, Emilie Charpentier, Pierre Weicherding, Claude P Muller
Vaccine coverage of the general population in Luxembourg is high, but refugees or asylum seekers may be incompletely vaccinated and susceptible to vaccine-preventable diseases. In order to assess protection rates, serum and oral fluid samples were collected from 406 newcomers aged between 13 and 70 years arriving between May and September 2012. Sera were screened for IgG antibodies against measles, rubella, mumps, hepatitis B, tetanus, diphtheria and pertussis. Oral fluid samples were screened for antibodies against measles, mumps and rubella virus to investigate their suitability for antibody prevalence studies...
January 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29306504/response-to-donahue-et-al-2017-in-press-article
#20
LETTER
Kevin A Ault, Laura E Riley
No abstract text is available yet for this article.
January 3, 2018: Vaccine
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