Hongyu Yang, Faxing Zhang, Yingzhen Fan, Jian Zhang, Ting Fang, Dandan Xing, Yanli Zhen, Zhihao Nie, Yaming Liu, Dongkai Wang, Ji Li
PURPOSE: Traditional eye drops exhibit a modest bioavailability ranging from 1 to 5%, necessitating recurrent application. Thus, a contact lens-based drug delivery system presents substantial benefits. Nonetheless, pharmaceutical agents exhibiting poor solubility may compromise the quintessential characteristics of contact lenses and are, consequently, deemed unsuitable for incorporation. To address this issue, the present study has engineered a novel composite drug delivery system that amalgamates micellar technology with contact lenses, designed specifically for the efficacious conveyance of timolol and brinzolamide...
February 16, 2024: Pharmaceutical Research