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Minerva Endocrinologica

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https://www.readbyqxmd.com/read/28206728/laparoscopic-roux-en-y-gastric-bypass-vs-laparoscopic-sleeve-gastrectomy-for-morbid-obesity-a-systematic-review-and-meta-analysis-of-lipid-effects-at-one-year-post-surgery
#1
Elisenda Climent, David Benaiges, Juan Pedro-Botet, Albert Goday, Ivan Solà, José M Ramón, Juana A Flores-LE Roux, Miguel Á Checa
INTRODUCTION: Results of the effects of Roux-en-Y gastric bypass (GB) and sleeve gastrectomy (SG) on triglyceride and high-density lipoprotein (HDL) cholesterol levels are controversial. Moreover, previous meta-analyses focused on global dyslipidaemia remission, but did not include the separate remission rates of the different lipid fractions. Hence, the aim of the present meta-analysis was to compare the outcomes (concentration change and remission rates) of GB and SG on diverse lipid disorders one year post-bariatric surgery (BS)...
February 15, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28181781/thyroid-dysfunction-and-nonalcoholic-fatty-liver-disease
#2
Zoe A Efstathiadou, Marina D Kita, Stergios A Polyzos
Thyroid hormones are crucial for hepatic lipid and glucose metabolism. Nonalcoholic fatty liver disease (NAFLD), a very common and potentially serious disease of modern society, shares common clinical features with hypothyroidism, such as obesity, insulin resistance and dyslipidemia. Furthermore, in certain studies, increased prevalence of hypothyroidism was observed in patients with NAFLD. However, whether there is a linear relationship between thyroid hormone levels and NAFLD incidence and severity, including values within or in proximity to the reference range remains a contradictory subject in the literature...
February 9, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28181780/diagnosis-treatment-clinical-course-and-prognosis-of-childhood-onset-craniopharyngioma-patients
#3
Hermann L Müller
CONTEXT: For decades gross-total resection was the preferred treatment option in childhood-onset craniopharyngioma, assuming that radical strategies at the time of initial diagnosis and treatment would result in cure. Recent reports on long-term prognosis, novel treatment approaches, and molecular genetics provide new insights into more risk-adapted treatment strategies in order to prevent sequelae such as hypothalamic syndrome. EVIDENCE ACQUISITION: A search for original articles published between 2000 and 2016 was performed in PubMed, Science Citation Index Expanded, EMBASE and Scopus...
February 9, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28146141/type-1-diabetes-from-adolescence-to-adulthood-is-there-a-permanent-need-for-nutrition-education-and-reeducation
#4
Maja Baretić, Martina Matovinović Osvatić, Eva Pavić, Nada Rabađija, Valentina Uroić, Carolina Koletić, Nataša Rojnić Putarek, Ivana Pavlić Renar
BACKGROUND: The transition for type 1 diabetes patients from paediatric to adult diabetology care is challenging process for both medical team and patients. Adult diabetology usually insists on stricter goals and focuses on increased empowerment and self-care. We set to find a more practical and effective way to determine patient knowledge and skills during the transition. The aim of the study was to identify screening questions which best represent knowledge in management of type 1 diabetes and to explore the differences in the effect of a structured educational program for type 1 diabetes patient diagnosed in childhood versus adulthood...
January 31, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28146140/tumor-and-normal-thyroid-spheroids-from-tissues-to-zebrafish
#5
Valentina Cirello, Germano Gaudenzi, Elisa S Grassi, Carla Colombo, Leonardo Vicentini, Stefano Ferrero, Luca Persani, Giovanni Vitale, Laura Fugazzola
BACKGROUND: Multicellular spheroids represent an interesting experimental model with promising applications in the pre-clinical studies on anticancer drugs. We recently demonstrated that thyroid spheroids recapitulate the features of the original tissues, in either the differentiated and "stem-like" components. Here we were aimed to characterize thyroid spheroids and to investigate in vivo the proangiogenic potential of patient-derived xenografts (PDX) of spheroids obtained from papillary thyroid cancer (PTC) and the matched normal tissues...
January 31, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28146139/is-cardiovascular-risk-in-women-with-pcos-a-real-risk-current-insights
#6
Georgios Papadakis, Eleni Kandaraki, Olga Papalou, Andromachi Vryonidou, Evanthia Diamanti-Kandarakis
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive aged women. PCOS incorporates not only symptoms related to the reproductive system but also a clustering of systemic metabolic abnormalities that are linked with increased risk for cardiovascular disease (CVD). More specifically, metabolic aberrations such as impaired glucose and lipid metabolism, accompanied by increased low-grade inflammation as well as elevated coagulation factors appear to contribute to the increased cardiovascular risk...
January 31, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28146138/comparison-the-relationship-between-the-levels-of-insulin-resistance-hs-crp-percentage-of-body-fat-and-serum-osteoprotegerin-receptor-activator-of-nuclear-factor-%C3%AE%C2%BA%C3%AE-ligand-in-prediabetic-patients
#7
Oktay Bilgir, Mehmet Yavuz, Ferda Bilgir, Ozden Y Akan, Aslı G Bayindir, Mehmet Calan, Giray Bozkaya, Arif Yuksel
: BACKGROUND Receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin (OPN) are soluble members of the tumor necrosis factor superfamily. Growing evidence suggest that there is link between inflammation, insulin resistance and OPG, sRANKL. We aimed to ascertain whether OPG and sRANKL levels are altered in prediabetic subjects and there is association between OPG, sRANKL and metabolic parameters. MATERIAL AND METHODS: 40 prediabetic subjects and 40 age- and BMI-matched controls were recruited for this cross-sectional study...
January 31, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28092147/should-serum-calcitonin-be-routinely-measured-in-patients-presenting-with-thyroid-nodule
#8
William P Tormey, Brendan Byrne, Arnold D Hill, Mark Sherlock, Christopher J Thompson
BACKGROUND: The European Thyroid Association recommends serum calcitonin measurement in thyroid nodule cases. In contrast, the American Thyroid Association is ambivalent. In this institution, thyroid nodules cases are subject to a multidisciplinary evaluation of the clinical history and examination, ultrasound and scintigraphy, CT scan and sometimes MRI scan, biochemistry and histopathology of biopsies. We report on the current use of plasma calcitonin measurements in the context of changing practice which has not included screening of all thyroid nodules...
January 13, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28001017/improvement-of-bone-turnover-markers-and-bone-mineral-density-following-treatment-of-primary-aldosteronism
#9
Huai H Loh, Nor A Kamaruddin, Rozman Zakaria, Norlela Sukor
BACKGROUND: Recent studies showed association between hyperaldosteronism and low bone density among patients with primary aldosteronism (PA) due to secondary hyperparathyroidism. Our objective is to assess bone turnover markers (BTM) and bone mineral density (BMD) of PA patients compared to essential hypertension. METHODS: This was an open-label, prospective, case-controlled study, conducted over 12 months. Fifty-two consecutive patients referred for secondary hypertension were screened...
December 20, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28001016/effect-of-dapagliflozin-administration-on-metabolic-syndrome-insulin-sensitivity-and-insulin-secretion
#10
Manuel González-Ortiz, Miriam Méndez-Del Villar, Esperanza Martínez-Abundis, Alejandra M Ramírez-Rodríguez
AIM: To evaluate the effect of dapagliflozin on metabolic syndrome (MetS), insulin sensitivity and insulin secretion. METHODS: A randomized, double blind, placebo-controlled clinical trial was carried out in 24 patients with MetS. Glucose and insulin levels were measured every 30 min for 2-h after a 75-g dextrose load. Metabolic profile was also evaluated before and after the pharmacological intervention. Twelve patients received dapagliflozin (10 mg) before breakfast for 90 days...
December 20, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27990792/diabetes-mellitus-and-non-alcoholic-fatty-liver-disease-the-thread-of-ariadne
#11
Maria Kosmidou, Haralampos Milionis
Non alcoholic fatty liver disease (NAFLD, the hepatic fat accumulation) and non alcoholic steatohepatitis (NASH, the aggressive form of liver steatosis plus inflammation and hepatocyte necrosis) are reaching epidemic dimensions in subjects with diabetes mellitus (DM). Taking into account that the incidence of DM increases worldwide, these entities rerpresent major health problems. There is accumulating evidence that diabetic subjects with NASH are at increased risk not only for cardiovascular disease compications but also for cirrhosis and hepatocellular cancer...
December 16, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27973461/bone-metabolism-in-non-alcoholic-fatty-liver-disease-vitamin-d-status-and-bone-mineral-density
#12
Ahad Eshraghian
Non alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and liver enzymes abnormalities worldwide. NAFLD is reported to be associated with other extra-hepatic diseases including cardiovascular disease, diabetes mellites and thyroid gland abnormalities. Liver is also the source of many proteins involved in bone metabolism and is the regulator of several bone metabolism pathways. Although underlying pathogenesis is not clear, the association between NAFLD and low bone mineral density (BMD) in the forms of osteoporosis and osteopenia have been recently reported...
December 14, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27973460/adrenal-disorders-and-nonalcoholic-fatty-liver-disease
#13
Labrini Papanastasiou, Stelios Fountoulakis, Ioannis A Vatalas
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the developed world and its pathogenesis is complex and multifactorial. It is considered the hepatic manifestation of the metabolic syndrome and is the leading cause of hepatic cirrhosis. This review aims to present current knowledge on the involvement of the adrenal glands in the development of NAFLD. Clinical and animal studies have shown that excess glucocorticoids (GC) have been implicated in the pathogenesis of NAFLD. Patients with NAFLD seem to have a subtle chronic activation of the hypothalamic pituitary adrenal axis leading to a state of subclinical hypercortisolism...
December 14, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27901334/differential-efficacy-of-methylcobalamin-and-alpha-lipoic-acid-treatment-on-negative-and-positive-symptoms-of-type-2-diabetic-peripheral-neuropathy
#14
Yajuan Han, Min Wang, Jie Shen, Zhen Zhang, Min Zhao, Jing Huang, Youming Chen, Zhi Chen, Yulan Hu, Yubing Wang
BACKGROUND: Diabetic hyperglycemia damages peripheral nerves by triggering ischemia, oxidative stress, and inflammation. Alpha-lipoic acid (ALA) and methylcobalamin (MC) are known to improve signs of diabetic peripheral neuropathy (DPN), possibly by enhancing neural and vascular endothelial cell metabolism and antioxidant capacity. We evaluated differences in efficacy following short-term MC or ALA treatment on DPN symptoms to guide clinical drug selection. METHODS: Forty DPN patients were randomly divided into MC and ALA treatment groups (n=20/20) and assessed by the Toronto Clinical Neuropathy Scoring System (TCSS), total symptom score (TSS), visual analog scale (VAS) of positive symptoms, and easy sensory test (EST) for negative symptoms before and after 2 weeks of treatment...
November 30, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27600645/lifestyle-changes-in-the-management-of-adulthood-and-childhood-obesity
#15
Francesco Orio, Domenico Tafuri, Antonio Ascione, Francesca Marciano, Silvia Savastano, Giorgio Colarieti, Marcello Orio, Annamaria Colao, Stefano Palomba, Giovanna Muscogiuri
Adulthood and childhood obesity is rapidly becoming an epidemic problem and it has a short and long-term impact on health. Short-term consequences are mostly represented by psychological effects; in fact obese children have more chances to develop psychological or psychiatric problems than non-obese children. The main long-term effect is represented by the fact that childhood obesity continues into adulthood obesity and this results in negative effects in young adult life, since obesity increases the risk to develop morbidity and premature mortality...
December 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27600644/obesity-single-house-for-many-evils
#16
Ashwini Kumar, Bibhukalyan P Nayak, Awanish Kumar
World Health Organization (WHO) considers obesity as one of the fastest growing metabolic disorders other than diabetes. It is a complex interplay of lifestyle and associated genes. Obesity has been considered as a disease with multiple targets and very often compared in this sense with its sibling disease type 2 diabetes. The disease is pathology of the adipocytes and develops as a result of hypertrophy and hyperplasia of these cells, former being the major concern but its effects could be seen on various organs in the form of cardio-vascular disease, stroke, cancer, diabetes, sexual dysfunction, respiratory problems and many more...
December 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27600643/endoscopic-imaging-in-the-management-of-gastroenteropancreatic-neuroendocrine-tumors
#17
Rinaldo Pellicano, Sharmila Fagoonee, Fiorella Altruda, Mauro Bruno, Giorgio M Saracco, Claudio De Angelis
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors deriving from the gastrointestinal (GI) neuroendocrine system. Since these neoplasms are usually very small, located deeply within the retroperitoneum or into an extramucosal site of the GI tract and, lastly, because they may be multi-sited, radiological imaging modalities, in combination with endoscopy, are the diagnostic workhorses in patients with GEP-NETs. Endoscopic approach is useful for detection, bioptic diagnosis and curative resection of small GEP-NETs of stomach, duodenum, jejuno-ileum, and colon-rectum...
December 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27600642/type-ii-diabetes-patients-with-proteinuria-and-the-recovery-of-their-metabolic-parameters
#18
Ya Z Liu, Keqi Wang, Xiang Li, Bin Chen
BACKGROUND: The aim of this study was to provide reasonable guidelines for type II diabetes patients with proteinuria to recover their metabolic parameters. METHODS: A cross-sectional study was conducted in selected groups of type 2 diabetic patients. Hypoglycemic and antihypertensive drug use was recorded. Certain physical examinations were conducted including routine urine test, urinary albumin/creatinine ratio (ACR), metabolic parameters of blood glucose and lipid, and other biochemical indicators...
December 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27600641/fasting-glycemia-at-the-first-prenatal-visit-and-pregnancy-outcomes-in-russian-women
#19
Polina Popova, Alexandra Tkachuk, Alexandra Dronova, Andrey Gerasimov, Ekaterina Kravchuk, Maria Bolshakova, Olga Rozdestvenskaya, Ksenia Demidova, Alla Nikolaeva, Elena Grineva
BACKGROUND: The aim of this study was to evaluate the associations between fasting glycemia (FG) at the first prenatal visit and adverse pregnancy outcomes. METHODS: Medical records of 1584 pregnant women with a recorded level of FG <7 mmol/L before 24 weeks of gestation and delivery after 24 weeks were examined 823 of them underwent oral glucose tolerance test (OGTT) at 24-32 weeks of pregnancy. FG values were devided into five groups starting with <4.1 mmol/L as the first group, with subsequent increases of 0...
December 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27600640/diabetes-mellitus-and-cardiovascular-disease-strategies-for-prevention
#20
Elena Grineva
No abstract text is available yet for this article.
December 2016: Minerva Endocrinologica
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