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Minerva Endocrinologica

Stergios A Polyzos, Jannis Kountouras, Christos S Mantzoros
The association of obesity with nonalcoholic fatty liver disease (NAFLD) has been established. Obesity has been linked not only to initial stages of the disease, i.e., simple steatosis (SS), but also to its severity. Form an epidemiologic point of view, both diseases has an increasing prevalence worldwide. From a pathogenetic point of view, obesity and its associate IR contribute to the initial fat accumulation in the hepatocyte (SS), but also to the progression of SS to nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis and hepatocellular carcinoma (HCC)...
October 6, 2016: Minerva Endocrinologica
Fabio Pagni, Giovanni Casella, Francesca M Bosisio, Marilena Costantini, Giannantonio Fioretta, Guglielmo Nicoletti, Vittorio Baldini, Camillo Di Bella
No abstract text is available yet for this article.
September 27, 2016: Minerva Endocrinologica
Gabriela Monroy, Diana Tundidor, Inmaculada Orellana, Apolonia García-Patterson, Juan M Adelantado, Rosa Corcoy
BACKGROUND: Numerous studies have evaluated the predictors of large-for-gestational- age newborns (LGA) as well as abnormal glucose tolerance (AGT) after delivery in women with gestatonal diabetes mellitus, one at a time. The present study assess the ability of glucose values on the antenatal oral glucose tolerance test (OGTT) to predict both outcomes. METHODS: Retrospective analysis of a prospectively collected database. Gestational diabetes was diagnosed with a two-step approach...
September 22, 2016: Minerva Endocrinologica
Roya Kolahdouz Mohammadi, Minoo Bagheri, Mina Kolahdouz Mohammadi, Farzad Shidfar
INTRODUCTION: R-TFA (ruminant trans-fatty acids) especially cis9, trans11-conjugated linoleic acid (c9,t11-CLA) and trans11-18:1 vaccenic acid (t11-18:1 VA) appear to have anticarcinogenic activity against breast cancer in animal and in vitro experiments. However, the results remain inconsistent. We therefore conducted a systematic review and meta- analysis to assess the association of c9,t11-CLA, and t11-18:1 VA (intake or serum levels) with breast cancer risk. EVIDENCE ACQUISITION: Relevant studies were identified by a search of PubMed, OVID, SCOPUS and Google scholar databases through 25 May 2015...
September 14, 2016: Minerva Endocrinologica
Marta Kiałka, Tomasz Milewicz, Sandra Mrozińska, Iwona Rogatko, Krystyna Sztefko, Renata Majewska
BACKGROUND: Despite some evidence that indicates that the evolution of PCOS is related to the activity of the endogenous opioid system, and that concentration of plasma β-endorphin levels can increase pain threshold, there are no studies which evaluate pressure pain threshold in the PCOS women population. METHODS: In 48 lean women with PCOS and 38 lean women without this disorder plasma β-endorphins and PPT were measured. RESULTS: The Beta-endorphins level was higher in the PCOS group compared to the controls (15...
September 7, 2016: Minerva Endocrinologica
Paolo Del Rio, Chiara Montana Montana, Giulia Mingardi, Giovanna Piva, Mario Sianesi, Luigi Corcione
BACKGROUND: The incidence of thyroid carcinoma goes from 0.5 to 10 cases on 100.000, depending on the country, the context and purpose of the study. The high incidence of differentiated thyroid tumor is continuously growing. While most malignant pathologies affect the adults, a proportion of 1-2 % of paediatric population is affected by solitary nodule, of which some are malignant cancers. Studying thyroid malignant cancer, the most sensitive and accurate imaging technique is the colorDoppler ultrasounds...
September 2, 2016: Minerva Endocrinologica
Francesco Orio, Domenico Tafuri, Antonio Ascione, Francesca Marciano, Silvia Savastano, Giorgio Colarieti, Marcello Orio, Annamaria Colao, Stefano Palomba, Giovanna Muscogiuri
Adulthood and childhood obesity is rapidly becoming an epidemic problem and it has a short and long-term impact on health. Short-term consequences are mostly represented by psychological effects; in fact obese children have more chances to develop psychological or psychiatric problems than non-obese children. The main long-term effect is represented by the fact that childhood obesity continues into adulthood obesity and this results in negative effects in young adult life, since obesity increases the risk to develop morbidity and premature mortality...
December 2016: Minerva Endocrinologica
Ashwini Kumar, Bibhukalyan P Nayak, Awanish Kumar
World Health Organization (WHO) considers obesity as one of the fastest growing metabolic disorders other than diabetes. It is a complex interplay of lifestyle and associated genes. Obesity has been considered as a disease with multiple targets and very often compared in this sense with its sibling disease type 2 diabetes. The disease is pathology of the adipocytes and develops as a result of hypertrophy and hyperplasia of these cells, former being the major concern but its effects could be seen on various organs in the form of cardio-vascular disease, stroke, cancer, diabetes, sexual dysfunction, respiratory problems and many more...
December 2016: Minerva Endocrinologica
Rinaldo Pellicano, Sharmila Fagoonee, Fiorella Altruda, Mauro Bruno, Giorgio M Saracco, Claudio De Angelis
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors deriving from the gastrointestinal (GI) neuroendocrine system. Since these neoplasms are usually very small, located deeply within the retroperitoneum or into an extramucosal site of the GI tract and, lastly, because they may be multi-sited, radiological imaging modalities, in combination with endoscopy, are the diagnostic workhorses in patients with GEP-NETs. Endoscopic approach is useful for detection, bioptic diagnosis and curative resection of small GEP-NETs of stomach, duodenum, jejuno-ileum, and colon-rectum...
December 2016: Minerva Endocrinologica
Ya Z Liu, Keqi Wang, Xiang Li, Bin Chen
BACKGROUND: The aim of this study was to provide reasonable guidelines for type II diabetes patients with proteinuria to recover their metabolic parameters. METHODS: A cross-sectional study was conducted in selected groups of type 2 diabetic patients. Hypoglycemic and antihypertensive drug use was recorded. Certain physical examinations were conducted including routine urine test, urinary albumin/creatinine ratio (ACR), metabolic parameters of blood glucose and lipid, and other biochemical indicators...
December 2016: Minerva Endocrinologica
Polina Popova, Alexandra Tkachuk, Alexandra Dronova, Andrey Gerasimov, Ekaterina Kravchuk, Maria Bolshakova, Olga Rozdestvenskaya, Ksenia Demidova, Alla Nikolaeva, Elena Grineva
BACKGROUND: The aim of this study was to evaluate the associations between fasting glycemia (FG) at the first prenatal visit and adverse pregnancy outcomes. METHODS: Medical records of 1584 pregnant women with a recorded level of FG <7 mmol/L before 24 weeks of gestation and delivery after 24 weeks were examined 823 of them underwent oral glucose tolerance test (OGTT) at 24-32 weeks of pregnancy. FG values were devided into five groups starting with <4.1 mmol/L as the first group, with subsequent increases of 0...
December 2016: Minerva Endocrinologica
Elena Grineva
No abstract text is available yet for this article.
December 2016: Minerva Endocrinologica
Surendra Ugale, Deepa Agarwal, Vasisht Satwalekar, Nageswar Rao, Ayushka Ugale
Bariatric surgery has been found to be very useful in treating established type-2 diabetes in obese persons, as well as in borderline diabetics, besides giving a good weight loss. Various modifications of the primary bariatric procedures have been introduced, with differ advantages and better efficacy. Good incretin responses from the distal gut give the best results and combining medical treatment are helping patients to get very good glycemic control over a longer term.
December 2016: Minerva Endocrinologica
Kristin Castorino, Paige K Bradley, Lydia Truong, Jenny Martinez
Gestational diabetes affects up to one in five pregnancies and can have significant consequences for both mother and baby. There have been great efforts to identify strategies to prevent gestational diabetes during pregnancy. These efforts have been extended to the pre-pregnancy and postpartum periods to address limitations during pregnancy. In this review we explore how diet, exercise and lifestyle modification can be used to prevent gestational diabetes.
December 2016: Minerva Endocrinologica
Natalia Rudovich, Olga Pivovarova, Wolfgang Bernigau, Andrea Sparwasser, Christopher Tacke, Veronica Murahovshi, Gabriele Mertes, Andreas L Birkenfeld, Andreas Bergmann, Martin O Weickert, Andreas F Pfeiffer
BACKGROUND: Acarbose, an alpha-glucosidase inhibitor, unexpectedly reduced the incidence of hypertension and cardiovascular endpoints in the STOP-NIDDM study. Based on the growing evidence of a link between vasoregulatory peptides and metabolic traits, we hypothesized that changes of the Glycemic Index by acarbose may modulate vasoregulatory peptide levels via regulation of postprandial metabolism. METHODS: Subjects with type 2 diabetes and with metabolic syndrome were treated with acarbose (12 weeks, 300mg/d) in a double-blind, placebo-controlled, cross-over intervention...
December 2016: Minerva Endocrinologica
Tatiana Y Kostrominova
Obesity is reaching epidemic proportions in developed countries and is on the rise in developing countries. Obesity-related changes in lipid and glucose metabolism predispose to the development of metabolic syndrome and type 2 diabetes. Skeletal muscle constitutes about 40 percent of total body weight and is unique compared to other muscle types since it is one of the most important organs for insulin-dependent glucose metabolism in humans. Abnormalities in skeletal muscle lipid and glucose metabolism as well as abnormal accumulation of intramyocellular lipids could predispose for the development of type 2 diabetes...
December 2016: Minerva Endocrinologica
Elzbieta Wierzbicka, Mieczyslaw Szalecki, Pawel Pludowski, Maciej Jaworski, Anna Brzozowska
BACKGROUND: High prevalence of vitamin D deficiency in adolescents with type 1 diabetes (T1DM) has been recorded but data focused on the relationship between vitamin D, glycemic control and body composition is limited in T1DM patients. The study was aimed to investigate vitamin D status in T1DM patients and its association with body composition (fat and lean body mass) and clinical data. METHODS: The study group comprised of 100 adolescents (15.3±1.9 yrs; 54 girls), including 60 T1DM patients (15...
December 2016: Minerva Endocrinologica
Ilan Shimon
No abstract text is available yet for this article.
September 2016: Minerva Endocrinologica
Andrea Glezer, Raquel S Jallad, Marcio C Machado, Maria C Fragoso, Marcello D Bronstein
Infertility is frequent in patients harboring pituitary adenomas. The mechanisms involved include hypogonadism secondary to hormonal hypersecretion (prolactin, growth hormone and cortisol), stalk disconnection and pituitary damage. With the improvement of clinical and surgical treatment, pregnancy in women harboring pituitary adenomas turned into a reality. Pituitary hormonal hyper- and hyposecretion influences pregnancy outcomes, as well as pregnancy can interfere on pituitary tumors, especially in prolactinomas...
September 2016: Minerva Endocrinologica
Daniel Cuevas-Ramos, Maria Fleseriu
Cushing's Syndrome (CS) is a serious endocrine disease that results from the adverse clinical consequences of chronic exposure to high levels of glucocorticoids. Most patients with endogenous CS have an adrenocorticotropin (ACTH)-secreting pituitary corticotroph adenoma, i.e. Cushing's Disease (CD). The first-line therapy for CD is transsphenoidal pituitary surgery. If tumor removal is incomplete or unsuccessful, persistent hypercortisolism will require further treatment. Repeat surgery, medical therapy, radiation and bilateral adrenalectomy are all second line therapy options; however, medical therapy can be also used as first line therapy in patients who cannot undergo surgery, or to decrease cortisol values and/or improve co-morbidities...
September 2016: Minerva Endocrinologica
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