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Minerva Endocrinologica

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https://www.readbyqxmd.com/read/28001017/improvement-of-bone-turnover-markers-and-bone-mineral-density-following-treatment-of-primary-aldosteronism
#1
Huai H Loh, Nor A Kamaruddin, Rozman Zakaria, Norlela Sukor
BACKGROUND: Recent studies showed association between hyperaldosteronism and low bone density among patients with primary aldosteronism (PA) due to secondary hyperparathyroidism. Our objective is to assess bone turnover markers (BTM) and bone mineral density (BMD) of PA patients compared to essential hypertension. METHODS: This was an open-label, prospective, case-controlled study, conducted over 12 months. Fifty-two consecutive patients referred for secondary hypertension were screened...
December 20, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28001016/effect-of-dapagliflozin-administration-on-metabolic-syndrome-insulin-sensitivity-and-insulin-secretion
#2
Manuel González-Ortiz, Miriam Méndez-Del Villar, Esperanza Martínez-Abundis, Alejandra M Ramírez-Rodríguez
AIM: To evaluate the effect of dapagliflozin on metabolic syndrome (MetS), insulin sensitivity and insulin secretion. METHODS: A randomized, double blind, placebo-controlled clinical trial was carried out in 24 patients with MetS. Glucose and insulin levels were measured every 30 min for 2-h after a 75-g dextrose load. Metabolic profile was also evaluated before and after the pharmacological intervention. Twelve patients received dapagliflozin (10 mg) before breakfast for 90 days...
December 20, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27990792/diabetes-mellitus-and-non-alcoholic-fatty-liver-disease-the-thread-of-ariadne
#3
Maria Kosmidou, Haralampos Milionis
Non alcoholic fatty liver disease (NAFLD, the hepatic fat accumulation) and non alcoholic steatohepatitis (NASH, the aggressive form of liver steatosis plus inflammation and hepatocyte necrosis) are reaching epidemic dimensions in subjects with diabetes mellitus (DM). Taking into account that the incidence of DM increases worldwide, these entities rerpresent major health problems. There is accumulating evidence that diabetic subjects with NASH are at increased risk not only for cardiovascular disease compications but also for cirrhosis and hepatocellular cancer...
December 16, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27973461/bone-metabolism-in-non-alcoholic-fatty-liver-disease-vitamin-d-status-and-bone-mineral-density
#4
Ahad Eshraghian
Non alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and liver enzymes abnormalities worldwide. NAFLD is reported to be associated with other extra-hepatic diseases including cardiovascular disease, diabetes mellites and thyroid gland abnormalities. Liver is also the source of many proteins involved in bone metabolism and is the regulator of several bone metabolism pathways. Although underlying pathogenesis is not clear, the association between NAFLD and low bone mineral density (BMD) in the forms of osteoporosis and osteopenia have been recently reported...
December 14, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27973460/adrenal-disorders-and-nonalcoholic-fatty-liver-disease
#5
Labrini Papanastasiou, Stelios Fountoulakis, Ioannis A Vatalas
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the developed world and its pathogenesis is complex and multifactorial. It is considered the hepatic manifestation of the metabolic syndrome and is the leading cause of hepatic cirrhosis. This review aims to present current knowledge on the involvement of the adrenal glands in the development of NAFLD. Clinical and animal studies have shown that excess glucocorticoids (GC) have been implicated in the pathogenesis of NAFLD. Patients with NAFLD seem to have a subtle chronic activation of the hypothalamic pituitary adrenal axis leading to a state of subclinical hypercortisolism...
December 14, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27901334/differential-efficacy-of-methylcobalamin-and-alpha-lipoic-acid-treatment-on-negative-and-positive-symptoms-of-type-2-diabetic-peripheral-neuropathy
#6
Yajuan Han, Min Wang, Jie Shen, Zhen Zhang, Min Zhao, Jing Huang, Youming Chen, Zhi Chen, Yulan Hu, Yubing Wang
BACKGROUND: Diabetic hyperglycemia damages peripheral nerves by triggering ischemia, oxidative stress, and inflammation. Alpha-lipoic acid (ALA) and methylcobalamin (MC) are known to improve signs of diabetic peripheral neuropathy (DPN), possibly by enhancing neural and vascular endothelial cell metabolism and antioxidant capacity. We evaluated differences in efficacy following short-term MC or ALA treatment on DPN symptoms to guide clinical drug selection. METHODS: Forty DPN patients were randomly divided into MC and ALA treatment groups (n=20/20) and assessed by the Toronto Clinical Neuropathy Scoring System (TCSS), total symptom score (TSS), visual analog scale (VAS) of positive symptoms, and easy sensory test (EST) for negative symptoms before and after 2 weeks of treatment...
November 30, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27879963/hypogonadism-and-non-alcoholic-fatty-liver-disease
#7
Gesthimani Mintziori, Pavlos Poulakos, Christos Tsametis, Dimitrios G Goulis
Non-alcoholic fatty liver disease (NAFLD) is more common in men than in women. Thus, it has been suggested that sex steroids do have a role in the development of NAFLD. The aim of the current paper is to illustrate the association between NAFLD and hypogonadism, by reviewing data derived from both human and animal studies. The prevalence of NAFLD is high in men with hypogonadism, including those with idiopathic hypogonadotropic hypogonadism (IHH), as well as in women in post- menopause, those under estrogen receptor antagonist treatment or women with Turner syndrome...
November 23, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27879962/intestinal-hormones-gut-microbiota-and-nonalcoholic-fatty-liver-disease-nafld
#8
Nikolaos Koukias, Elena Buzzetti, Emmanuel A Tsochatzis
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and has a complex pathophysiology with multiple pathways of development and progression implicated. Intestinal hormones regulate multiple biological functions and may play a role in the pathogenesis of non alcoholic fatty liver disease (NAFLD) by affecting food intake, body weight and insulin resistance. Bacterial products can affect the secretion of these hormones and thus have an effect on metabolism. Gut microbiota are normally involved in the intestinal energy harvest and their role has been increasingly been implicated in the pathogenesis of obesity and NAFLD...
November 23, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27834478/iron-overload-and-nonalcoholic-fatty-liver-disease
#9
Christian Datz, Elena Müller, Elmar Aigner
Approximately one third of patients with non-alcoholic fatty liver disease (NAFLD) show signs of disturbed iron homeostasis as indicated by elevated serum ferritin with normal or mildly elevated transferrin saturation. Mild hepatic iron deposition is the typical histological finding in these subjects and the term "dysmetabolic iron overload syndrome (DIOS)" is now used to describe this syndrome. From a clinical point of view, excess iron likely aggravates the natural course of NAFLD with regard to liver-related endpoints and extrahepatic disease complications although sound evidence is still lacking...
November 11, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27824243/hypertriglyceridemic-waist-in-type-1-diabetes-patients-prevalence-and-related-factors
#10
Mercè Fernández-Miró, Juan J Chillarón, Mercè Albareda, Sara Fontserè, Cristina Colom, Lluís Vila, Juan Pedro-Botet, Juana A Flores LE-Roux
BACKGROUND: The hypertriglyceridemic waist has been linked to a higher number of cardiovascular risk factors and a greater probability of developing diabetes and cardiovascular disease. Around 50% of individuals with type 1 diabetes (T1D) are overweight or obese and triglyceridemia is associated with the onset of micro- and macrovascular complications. METHODS: A cross-sectional study was conducted in men with T1D to assess the association between the prevalence of hypertriglyceridemic waist and cardiovascular risk factors and hypogonadism...
November 8, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27808486/novel-acquisitions-in-the-diagnosis-of-medullary-thyroid-carcinoma
#11
Pierpaolo Trimboli, Anna Crescenzi, Enrico Saggiorato, Giorgio Treglia, Luca Giovanella
BACKGROUND: The correct identification of medullary thyroid carcinoma (MTC) has been a challenge since its first description. In the last years some advances in this context have been achieved. Here we aimed to review and discuss published data on the more recent acquisition in the diagnosis of MTC. METHODS: A literature search of the medical databases was conducted by searching papers reporting tool for diagnosis of MTC published in the last years. The search was updated until July 2016...
November 3, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27808485/concomitant-use-of-proton-pump-inhibitors-and-dual-antiplatelet-therapy-for-cardiovascular-outcomes
#12
Alessandro Mandurino-Mirizzi, Sergio Leonardi, Chiara Melloni
INTRODUCTION: The aim of this review is to discuss the consequences of potential pharmacokinetic interactions between proton pump inhibitors (PPIs) and antiplatelet therapy on cardiovascular (CV) outcomes and provide guidance on the management of concomitant use of PPIs in patients on dual antiplatelet therapy (DAPT). EVIDENCE ACQUISITION: DAPT combining aspirin and oral P2Y12 receptor inhibitors increases the risk of gastrointestinal (GI) bleeding, with higher rates of morbidity and mortality in patients undergoing percutaneous coronary intervention (PCI)...
November 3, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27792216/endocrine-and-metabolic-disorders-interplaying-with-nonalcoholic-fatty-liver-disease
#13
Stergios A Polyzos
No abstract text is available yet for this article.
October 28, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27792215/an-up-todate-on-the-methabolic-syndrome-s-epigenomic-risk
#14
Rosanna Perricone, Antonio Pizzuti
The primitive genome's and the individual phenotype's modifications by epygenesys surveyes are crucial to evaluate the methabolic syndrome risk and its prevention. Through the most recent surveys, this analysis is aimed to several processes by which the various epigenetic types who are different from one to another subject may act on the methabolism key-genes, like that they even indirectly arouse the straight onset of one or more methabolic syndromes: the risk of passing this syndrome to next offsprings is more or less high...
October 28, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27792214/prevalence-etiology-and-management-of-nonalcoholic-fatty-liver-disease-in-patients-with-polycystic-ovary-syndrome
#15
Evangelia Makri, Konstantinos Tziomalos
Obesity and insulin resistance (IR) are frequently present in patients with polycystic ovary syndrome (PCOS). Both disorders also play an important role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Accordingly, NAFLD is frequently present in patients with PCOS. In the present review, we summarize the findings of the major studies that assessed the prevalence of NAFLD in patients with PCOS. The factors driving the increased frequency of NAFLD in patients with PCOS are also analyzed. Finally, we discuss the management options of NAFLD in patients with PCOS...
October 28, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27792213/insulin-treatment-may-not-be-associated-with-worse-prognosis-in-acute-heart-failure-diabetic-patients
#16
Filipe M Cunha, Pedro Marques, Joana Pereira, Maria J Pinto, Pedro Rodrigues, Helena Moreira, Patrícia Lourenço, Paulo Bettencourt
BACKGROUND: Diabetic patients with heart failure (HF) treated with insulin appear to have a worse prognosis compared to oral anti-diabetic (OAD) agents. Whether insulin is a risk factor or a marker of disease severity is unknown. We studied the prognostic impact of insulin treatment in an acute HF diabetic population. METHODS: From a prospectively recruited population of hospital-admitted acute HF patients we retrospectively selected a convenience sample. Pair-matched analysis: each insulin-treated patient was matched with a diabetic patient with similar glycated haemoglobin (HbA1c±0...
October 28, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27600645/lifestyle-changes-in-the-management-of-adulthood-and-childhood-obesity
#17
Francesco Orio, Domenico Tafuri, Antonio Ascione, Francesca Marciano, Silvia Savastano, Giorgio Colarieti, Marcello Orio, Annamaria Colao, Stefano Palomba, Giovanna Muscogiuri
Adulthood and childhood obesity is rapidly becoming an epidemic problem and it has a short and long-term impact on health. Short-term consequences are mostly represented by psychological effects; in fact obese children have more chances to develop psychological or psychiatric problems than non-obese children. The main long-term effect is represented by the fact that childhood obesity continues into adulthood obesity and this results in negative effects in young adult life, since obesity increases the risk to develop morbidity and premature mortality...
December 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27600644/obesity-single-house-for-many-evils
#18
Ashwini Kumar, Bibhukalyan P Nayak, Awanish Kumar
World Health Organization (WHO) considers obesity as one of the fastest growing metabolic disorders other than diabetes. It is a complex interplay of lifestyle and associated genes. Obesity has been considered as a disease with multiple targets and very often compared in this sense with its sibling disease type 2 diabetes. The disease is pathology of the adipocytes and develops as a result of hypertrophy and hyperplasia of these cells, former being the major concern but its effects could be seen on various organs in the form of cardio-vascular disease, stroke, cancer, diabetes, sexual dysfunction, respiratory problems and many more...
December 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27600643/endoscopic-imaging-in-the-management-of-gastroenteropancreatic-neuroendocrine-tumors
#19
Rinaldo Pellicano, Sharmila Fagoonee, Fiorella Altruda, Mauro Bruno, Giorgio M Saracco, Claudio De Angelis
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors deriving from the gastrointestinal (GI) neuroendocrine system. Since these neoplasms are usually very small, located deeply within the retroperitoneum or into an extramucosal site of the GI tract and, lastly, because they may be multi-sited, radiological imaging modalities, in combination with endoscopy, are the diagnostic workhorses in patients with GEP-NETs. Endoscopic approach is useful for detection, bioptic diagnosis and curative resection of small GEP-NETs of stomach, duodenum, jejuno-ileum, and colon-rectum...
December 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27600642/type-ii-diabetes-patients-with-proteinuria-and-the-recovery-of-their-metabolic-parameters
#20
Ya Z Liu, Keqi Wang, Xiang Li, Bin Chen
BACKGROUND: The aim of this study was to provide reasonable guidelines for type II diabetes patients with proteinuria to recover their metabolic parameters. METHODS: A cross-sectional study was conducted in selected groups of type 2 diabetic patients. Hypoglycemic and antihypertensive drug use was recorded. Certain physical examinations were conducted including routine urine test, urinary albumin/creatinine ratio (ACR), metabolic parameters of blood glucose and lipid, and other biochemical indicators...
December 2016: Minerva Endocrinologica
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