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Journal of Leukocyte Biology

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https://www.readbyqxmd.com/read/29191867/editorial-countering-immune-regulation-stim-ulating-sle-disease-pathogenesis
#1
EDITORIAL
Kiera L Clayton, Mario M Ostrowski
No abstract text is available yet for this article.
December 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29191866/editorial-stressing-out-mast-cells-via-crf1
#2
EDITORIAL
Jonathan J Lyons, Helene F Rosenberg, Kirk M Druey
No abstract text is available yet for this article.
December 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29191865/editorial-on-matters-of-maturity-self-control-and-responsiveness-inhibitory-nk-receptors-in-the-driver-s-seat
#3
EDITORIAL
Michael G Brown, Awndre Gamache
No abstract text is available yet for this article.
December 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29030391/the-effect-of-plasma-auto-iggs-on-cd4-t-cell-apoptosis-and-recovery-in-hiv-infected-patients-under-antiretroviral-therapy
#4
Zhenwu Luo, Zejun Zhou, Elizabeth Ogunrinde, Tao Zhang, Zhen Li, Lisa Martin, Zhuang Wan, Hao Wu, Zhiqiang Qin, Tongwen Ou, Jiafeng Zhang, Lei Ma, Guoyang Liao, Sonya Heath, Lei Huang, Wei Jiang
Although effective antiretroviral therapy (ART) suppresses HIV viral replication, prevents AIDS-related complications, and prolongs life, a proportion of patients fails to restore the patients' CD4+ T cell number to the level of healthy individuals. Increased mortality and morbidity have been observed in these patients. In the current study, we have investigated the role of auto-IgGs in CD4+ T cell apoptosis and recovery in a cross-sectional study. All HIV+ subjects were on viral-suppressive ART treatment with a different degree of CD4+ T cell reconstitution...
December 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29018147/acute-lymphoblastic-leukemia-relapse-after-cd19-targeted-chimeric-antigen-receptor-t-cell-therapy
#5
REVIEW
Jiasheng Wang, Yongxian Hu, He Huang
CART19 therapy has revolutionized the treatment of CD19+ acute lymphoblastic leukemia, demonstrating an unprecedented complete remission rate; however, as follow-up prolongs, a high relapse rate after CART19 therapy has emerged as one of the major problems. Relapse can be attributed to the loss of leukemic cell immunogenicity, diminished function and amount of CART19 cells, and the inhibitory bone marrow microenvironment. Although studies to prevent and treat relapse have begun, some encouraging results have demonstrated the possibility of decreasing the relapse rate...
December 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28951421/differentiation-stage-specific-effect-of-histone-deacetylase-inhibitors-on-the-expression-of-ror%C3%AE-t-in-human-lymphocytes
#6
Anna Sałkowska, Kaja Karaś, Aurelia Walczak-Drzewiecka, Jarosław Dastych, Marcin Ratajewski
The role of epigenetic mechanisms in the regulation of the human RORγT gene, which encodes a Th17 lymphocyte signature transcription factor, remains largely unknown. We investigated the effect of histone deacetylase (HDAC) inhibition on RORγT and RORγT-dependent gene expression in human T lymphocytes. We found that, in Jurkat T cells and in in vitro-differentiated Th17 cells, treatment with 2 HDAC inhibitors, butyrate and apicidin, led to the induction of the RORγT gene, which was associated with an increase in histone H4 acetylation near the RORγT proximal promoter...
December 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29093133/editorial-gateway-to-monocyte-entry-into-the-brain-cxcr7-the-new-orchestra-conductor
#7
EDITORIAL
Steven D Douglas, Sergei Spitsin
No abstract text is available yet for this article.
November 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29093132/editorial-resolving-herpes-induced-ocular-pathology-can-fish-oil-really-do-that
#8
EDITORIAL
Anthony J St Leger
No abstract text is available yet for this article.
November 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28899907/a-novel-function-of-cxcl10-in-mediating-monocyte-production-of-proinflammatory-cytokines
#9
Qihong Zhao, Taeg Kim, Jian Pang, Wendy Sun, Xiaoxia Yang, Jinhong Wang, Yunling Song, Hongwei Zhang, Huadong Sun, Vangipuram Rangan, Shrikant Deshpande, Huaping Tang, Mary Ellen Cvijic, Richard Westhouse, Timothy Olah, Jenny Xie, Mary Struthers, Luisa Salter-Cid
IFN-γ-inducible protein 10 (CXCL10), a chemokine that is abundantly secreted in response to inflammatory stimuli, has been implicated in the pathogenesis of multiple inflammatory diseases, such as inflammatory bowel disease. Whereas CXCL10 is traditionally recognized for recruiting pathogenic T cells to inflamed sites, its nonchemotactic role during inflammation remains poorly defined. In this report, we identified a novel function of CXCL10 in the regulation of the inflammatory potential of human monocytes to produce cytokines...
November 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28877954/suppression-of-toll-like-receptor-2-mediated-proinflammatory-responses-by-mycobacterium-tuberculosis-protein-rv3529c
#10
Upasana Bandyopadhyay, Attinder Chadha, Priya Gupta, Brijendra Tiwari, Kausik Bhattacharyya, Sonam Popli, Rajagopal Raman, Vani Brahamachari, Yogendra Singh, Pawan Malhotra, Krishnamurthy Natarajan
Microorganisms are known to devise various strategies to thwart protective responses by the host. One such strategy is to incorporate sequences and domains in their genes/proteins that have similarity to various domains of the host proteins. In this study, we report that Mycobacterium tuberculosis protein Rv3529c exhibits significant similarity to the death domain of the TLR pathway adaptor protein MyD88. Incubation of macrophages with Rv3529c specifically inhibited TLR2-mediated proinflammatory responses. This included attenuated oxidative burst, reduced phosphorylation of MAPK-ERK, reduced activation of transcription factor NF-κB and reduced secretion of proinflammatory cytokines IFN-γ, IL-6, and IL-17A with a concomitant increased secretion of suppressor cytokines IL-10 and TGF-β...
November 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28877953/anti-inflammatory-roles-of-p38%C3%AE-mapk-in-macrophages-are-context-dependent-and-require-il-10
#11
Abbas Raza, Jessica W Crothers, Mahalia M McGill, Gary M Mawe, Cory Teuscher, Dimitry N Krementsov
The p38 MAPK pathway was originally identified as a master regulator of proinflammatory cytokine production by myeloid cells. Numerous drugs targeting this kinase showed promise in preclinical models of inflammatory disease, but so far, none have shown efficacy in clinical trials. The reasons behind this are unclear, but may, in part, be explained by emerging anti-inflammatory functions of this kinase or overly refined selectivity of second-generation pharmacologic inhibitors. Here, we show that p38α signaling in macrophages plays pro- and anti-inflammatory functions in vivo and in vitro, with the outcome depending on the stimulus, output, kinetics, or mode of kinase inhibition (genetic vs...
November 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28848043/fatty-acid-synthase-regulates-the-pathogenicity-of-th17-cells
#12
Kathryne E Young, Stephanie Flaherty, Kaitlyn M Woodman, Neelam Sharma-Walia, Joseph M Reynolds
T cell activation and effector function is characterized by changes in metabolism. Altered metabolism is common to almost all types of activated T cells, but fatty acid synthesis seems to especially drive the formation of Th17 cells. Indeed, research has demonstrated that inhibition of early fatty acid synthesis through targeting of acetyl-CoA carboxylase (ACC1) can inhibit Th17 cell formation and instead promote the generation of regulatory T cells. Fatty acid synthase (FASN) is downstream of ACC, and previous studies have shown that FASN activity influences both cancer and inflammation...
November 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28848041/chemokines-encoded-by-herpesviruses
#13
REVIEW
Sergio M Pontejo, Philip M Murphy
Viruses use diverse strategies to elude the immune system, including copying and repurposing host cytokine and cytokine receptor genes. For herpesviruses, the chemokine system of chemotactic cytokines and receptors is a common source of copied genes. Here, we review the current state of knowledge about herpesvirus-encoded chemokines and discuss their possible roles in viral pathogenesis, as well as their clinical potential as novel anti-inflammatory agents or targets for new antiviral strategies.
November 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28811319/galectin-8-activates-dendritic-cells-and-stimulates-antigen-specific-immune-response-elicitation
#14
Julieta Carabelli, Valeria Quattrocchi, Alejandra D'Antuono, Patricia Zamorano, María Virginia Tribulatti, Oscar Campetella
Galectin-8 (Gal-8) is a mammalian β-galactoside-binding lectin, endowed with proinflammatory properties. Given its capacity to enhance antigen-specific immune responses in vivo, we investigated whether Gal-8 was also able to promote APC activation to sustain T cell activation after priming. Both endogenous [dendritic cells (DCs)] and bone marrow-derived DCs (BMDCs) treated with exogenous Gal-8 exhibited a mature phenotype characterized by increased MHC class II (MHCII), CD80, and CD86 surface expression. Moreover, Gal-8-treated BMDCs (Gal-8-BMDCs) stimulated antigen-specific T cells more efficiently than immature BMDCs (iBMDCs)...
November 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28807929/human-mucosal-associated-invariant-t-mait-cells-possess-capacity-for-b-cell-help
#15
Michael S Bennett, Shubhanshi Trivedi, Anita S Iyer, J Scott Hale, Daniel T Leung
Mucosal-associated invariant T (MAIT) cells are an innate-like T cell subset, restricted by the nonclassic MHC class I-related protein MR1 and enriched at mucosal sites. Human studies have shown an association between MAIT cells and pathogen-specific antibody responses. In this study, we investigate the effect of human MAIT cells on B cells ex vivo. We found that supernatants from microbe- or cytokine-stimulated MAIT cells, when added to purified autologous B cells, increase frequencies of plasmablasts and promote IgA, IgG, and IgM production...
November 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28798144/frontline-science-leishmania-mexicana-amastigotes-can-replicate-within-neutrophils
#16
Benjamin P Hurrell, Manon Beaumann, Sandrina Heyde, Ivo B Regli, Andreas J Müller, Fabienne Tacchini-Cottier
Cutaneous leishmaniasis is a neglected tropical disease, causing a spectrum of clinical manifestations varying from self-healing to unhealing lesions that may be very difficult to treat. Emerging evidence points to a detrimental role for neutrophils during the first hours following infection with many distinct Leishmania species (spp.) at a time when the parasite is in its nonreplicative promastigote form. Neutrophils have also been detected at later stages of infection in unhealing chronic cutaneous lesions...
November 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28754798/frontline-science-cxcr7-mediates-cd14-cd16-monocyte-transmigration-across-the-blood-brain-barrier-a-potential-therapeutic-target-for-neuroaids
#17
Mike Veenstra, Dionna W Williams, Tina M Calderon, Kathryn Anastos, Susan Morgello, Joan W Berman
CD14(+)CD16(+) monocytes transmigrate into the CNS of HIV-positive people in response to chemokines elevated in the brains of infected individuals, including CXCL12. Entry of these cells leads to viral reservoirs, neuroinflammation, and neuronal damage. These may eventually lead to HIV-associated neurocognitive disorders. Although antiretroviral therapy (ART) has significantly improved the lives of HIV-infected people, the prevalence of cognitive deficits remains unchanged despite ART, still affecting >50% of infected individuals...
November 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28584076/frontline-science-aspirin-triggered-resolvin-d1-controls-herpes-simplex-virus-induced-corneal-immunopathology
#18
Naveen K Rajasagi, Siddheshvar Bhela, Siva Karthik Varanasi, Barry T Rouse
Stromal keratitis (SK) is a chronic immunopathological lesion of the eye, caused by HSV-1 infection, and a common cause of vision impairment in humans. The inflammatory lesions in the cornea are primarily caused by neutrophils with the active participation of CD4(+) T cells. Therefore, the targeting of these immune cell types and their products represents a potentially valuable form of therapy to reduce the severity of disease. Resolvin D1 (RvD1) and its epimer aspirin-triggered RvD1 (AT-RvD1) are lipid mediators derived from docosahexaenoic acid (DHA) and were shown to promote resolution in several inflammatory disease models...
November 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29021368/spontaneous-pmn-apoptosis-in-type-2-diabetes-and-the-impact-of-periodontitis
#19
Aggasit Manosudprasit, Alpdogan Kantarci, Hatice Hasturk, Danielle Stephens, Thomas E Van Dyke
The purpose of this study was to test the hypothesis that peripheral blood neutrophils (PMN) exhibit delayed spontaneous apoptosis in individuals with diabetes mellitus type 2 (T2DM) and that the delay is exacerbated further among people who coexpress chronic periodontitis (CP). Seventy-three individuals were enrolled, including those with T2DM (n = 16), CP (n = 15), T2DM + CP (n = 21), and healthy volunteers (n = 21). PMN apoptosis was determined by flow cytometry using TUNEL and Annexin V assays. The activity of caspase-3, -8, and -9 was measured by colorimetric assay...
October 11, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29021367/disruption-of-trim9-function-abrogates-macrophage-motility-in-vivo
#20
Debra A Tokarz, Amy K Heffelfinger, Dereje D Jima, Jamie Gerlach, Radhika N Shah, Ivan Rodriguez-Nunez, Amanda N Kortum, Ashley A Fletcher, Shila K Nordone, J McHugh Law, Steffen Heber, Jeffrey A Yoder
The vertebrate immune response comprises multiple molecular and cellular components that interface to provide defense against pathogens. Because of the dynamic complexity of the immune system and its interdependent innate and adaptive functionality, an understanding of the whole-organism response to pathogen exposure remains unresolved. Zebrafish larvae provide a unique model for overcoming this obstacle, because larvae are protected against pathogens while lacking a functional adaptive immune system during the first few weeks of life...
October 11, 2017: Journal of Leukocyte Biology
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