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Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society

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https://www.readbyqxmd.com/read/30230013/the-role-of-full-thickness-cartilage-defects-in-knee-osteoarthritis-oa-incidence-and-progression-data-from-the-oa-initiative
#1
Joshua S Everhart, Moneer M Abouljoud, David C Flanigan
The purpose of this study is to determine whether full-thickness tibiofemoral cartilage defects are predictive of incident radiographic OA, progression of radiographic OA, and progression to severe radiographic OA. Participants in the OA Initiative (n = 1317, 38.1% male, mean age 60.9 years SD 9.2) with baseline MRIs and Kellgren-Lawrence (KL) OA grade 0-3 (none to moderate OA) were included. All participants had follow-up radiographs at mean 4.9 years (max 8.0). The effect of full-thickness defect presence, size, and location on risk of incident OA (KL grade 2 +), overall progression of OA (increase in KL grade 1+ points), or compartment-specific OA progression was assessed with Cox proportional hazards modeling with adjustment for demographic factors, weight, and knee alignment...
September 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30230006/high-muscle-co-contraction-does-not-result-in-high-joint-forces-during-gait-in-anterior-cruciate-ligament-deficient-knees
#2
Ashutosh Khandha, Kurt Manal, Jacob Capin, Elizabeth Wellsandt, Adam Marmon, Lynn Snyder-Mackler, Thomas S Buchanan
The mechanism of knee osteoarthritis development after anterior cruciate ligament injuries is poorly understood. The objective of this study was to evaluate knee gait variables, muscle co-contraction indices and knee joint loading in young subjects with anterior cruciate ligament deficiency (ACLD, n = 36), versus control subjects (n = 12). A validated, electromyography-informed model was used to estimate joint loading. For the involved limb of ACLD subjects versus control, muscle co-contraction indices were higher for the medial (p = 0...
September 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30198576/the-origins-of-material-loss-in-highly-worn-acetabular-cups-of-metal-on-metal-total-hip-replacements
#3
Zhen Lu, Edward Ebramzadeh
Excessive wear has been one of the major failure modes of metal-on-metal hip implants. From a collection of 541 retrieved ASR metal-on-metal implants, we selected those head-cup pairs with combined wear >100mm3 , (N = 42) to assess the distributions of wear volume on cups, and non-conformance in the worn areas at the head-cup interfaces. All 42 had severe cup edge wear (average maximum wear depth 500µm). On average, 58% of wear volume of cups occurred at the edge areas, whereas 42% occurred well inside the socket, indicating that substantial wear volume of cups was generated well inside the socket...
September 10, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30183098/quantification-of-solute-diffusivity-in-osteoarthritic-human-femoral-cartilage-using-correlation-spectroscopy
#4
Brian T Graham, Alison D Wright, David L Burris, Michael J Axe, Leo W Raisis, Christopher Price
Osteoarthritis is a chronic joint disease characterized by articular cartilage degeneration, pain, and disability. As an avascular tissue, the movement of water and solutes through the tissue is critical to cartilage health and function, and early changes in solute diffusivity due to micro-scale changes in the properties of cartilage's extracellular matrix might precede clinical symptoms. A diagnostic technique for quantifying alteration to the diffusive environment of cartilage that precedes macroscopic changes may allow for the earlier identification of osteoarthritic disease, facilitating earlier intervention strategies...
September 5, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30175861/targeting-anti-chondrogenic-factors-for-the-stimulation-of-chondrogenesis-a-new-paradigm-in-cartilage-repair
#5
REVIEW
Andrea Lolli, Fabio Colella, Cosimo De Bari, Gerjo J V M van Osch
Trauma and age-related cartilage disorders represent a major global cause of morbidity, resulting in chronic pain and disability in patients. A lack of effective therapies, together with a rapidly aging population, creates an impressive clinical and economic burden on healthcare systems. In this scenario, experimental therapies based on transplantation or in situ stimulation of skeletal Mesenchymal Stem/progenitor Cells (MSCs) have raised great interest for cartilage repair. Nevertheless, the challenge of guiding MSC differentiation and preventing cartilage hypertrophy and calcification still needs to be overcome...
September 3, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30175859/promoting-effective-tendon-healing-and-remodeling
#6
Nelly Andarawis-Puri, Evan L Flatow
Daily activities subject our tendons to accumulation of sub-rupture fatigue injury which can lead to tendon rupture. Consequently, tendinopathies account for over 30% of musculoskeletal consultations. We adopted a multidisciplinary approach to determine the role of the extracellular matrix (ECM) in the pathogenesis of tendinopathy and impaired healing of ruptured tendons. We have been investigating three main areas: (i) the pathogenesis of tendon degeneration; (ii) approaches to promoting remodeling of sub-rupture fatigue injuries; and the (iii) role of the ECM in promoting scarless tendon healing...
September 3, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30175858/in-vivo-elongation-of-anterior-and-posterior-cruciate-ligament-in-bi-cruciate-retaining-total-knee-arthroplasty
#7
Tsung-Yuan Tsai, Ming H L Liow, Yun Peng, Paul Arauz, Guoan Li, Young-Min Kwon
Anterior and posterior cruciate ligament (ACL and PCL) sacrifice in contemporary total knee arthroplasty (TKA) has been considered a potential factor leading to abnormal knee kinematics. Bi-cruciate retaining (BCR) TKA design allows retention of both ACL and PCL. However, there is a limited data on the ACL/PCL in-vivo elongation characteristics of BCR TKA. The study aimed to evaluate and compare the in-vivo elongation patterns of ACL/PCL between BCR TKA and contralateral non-implanted knee and to explore potential factors leading to the changed elongation patterns between limbs...
September 3, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30175857/load-transfer-damage-and-failure-in-ligaments-and-tendons
#8
REVIEW
Jared L Zitnay, Jeffrey A Weiss
The function of ligaments and tendons is to support and transmit loads applied to the musculoskeletal system. These tissues are often able to perform their function for many decades; however, connective tissue disease and injury can compromise ligament and tendon integrity. A range of protein and non-protein constituents, combined in a complex structural hierarchy from the collagen molecule to the tissue and covering nanometer to centimeter length scales, govern tissue function, and impart characteristic non-linear material behavior...
September 3, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30175856/unravelling-the-hip-pistol-grip-cam-deformity-origins-to-joint-degeneration
#9
Paul E Beaulé, George Grammatopoulos, Andrew Speirs, K C Geoffrey Ng, Sasha Carsen, Hanspeter Frei, Gerd Melkus, Kawan Rakhra, Mario Lamontagne
This article reviews a body of work performed by the investigators over 9 years that has addressed the significance of cam morphology in the development of hip osteoarthritis (OA). Early hip joint degeneration is a common clinical presentation and preexisting abnormal joint morphology is a risk factor for its development. Interrogating Hill's criteria, we tested whether cam-type femoroacetabular impingement leads to hip OA. Strength of association was identified between cam morphology, reduced range-of-movement, hip pain, and cartilage degeneration...
September 3, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30175855/effect-of-structural-design-on-the-pullout-strength-of-suture-anchors-for-rotator-cuff-repair
#10
Soo-Won Chae, Ju-Yong Kang, Juneyoung Lee, Seung-Ho Han, Soung-Yon Kim
Various types of suture anchor designs are currently available for rotator cuff repair. The purpose of our study was to investigate the pullout strength of such anchors based on their structural design and the predominant geometric design factors affecting the pullout strength using finite element analysis. Finite element models were constructed using five cadaveric humeri and ten suture anchors with different designs. The pullout strength and distribution of bone stress around the anchor at three different directions of the applied force (0°, 45°, and 75°) were analyzed...
September 3, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30144138/effects-of-cobalt-and-chromium-ions-on-oxidative-stress-and-energy-metabolism-in-macrophages-in-vitro
#11
Zeina Salloum, Eric A Lehoux, Mary-Ellen Harper, Isabelle Catelas
Cobalt and chromium ions released from cobalt-chromium-molybdenum (CoCrMo)-based implants are a potential health concern, especially since both ions have been shown to induce oxidative stress in macrophages, the predominant immune cells in periprosthetic tissues. Other transition metal ions (Cd2+ , Ni2+ ) have been reported to inhibit the activity of mitochondrial enzymes in the electron transport chain. However, the effects of Co and Cr ions on the energy metabolism of macrophages remain largely unknown. The objective of the present study was to analyze the effects of Co2+ and Cr3+ on oxidative stress and energy metabolism in macrophages in vitro...
August 25, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30144134/development-and-validation-of-a-muscle-wrapping-model-applied-to-intact-and-reverse-total-shoulder-arthroplasty-shoulders
#12
Josie A Elwell, George S Athwal, Ryan Willing
Assessment and optimization of procedural outcomes, namely joint replacement, that rely heavily on muscle action necessitates a model capable of accurately and reliably predicting muscle paths in an automated setting. In this study, such a model was developed and validated for the anatomic shoulder and one implanted with reverse total shoulder arthroplasty (rTSA), as these scenarios present particularly complex ranges of motion and wrapping geometries. A finite element (FE) element model included a "string-of-pearls" representation of the four rotator cuff muscles and the three deltoid muscle bundles...
August 25, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30129682/lower-risk-of-fractures-under-methylphenidate-treatment-for-adhd-a-dose-response-effect
#13
Haggai Schermann, Ron Gurel, Ran Ankory, Assaf Kadar, Victoria Yoffe, Nimrod Snir, Amir Sternheim, Isabella Karakis
Methylphenidate (MP), a widely used and abused stimulant medication for ADHD, negatively affects bone mass. However, previous epidemiological studies demonstrated that MP is not associated with increased incidence of fractures in children, and may even have a protective effect due to behavior modification. This study aimed to investigate the association between MP and fracture risk in a retrospective cohort of healthy military recruits, aged 18-25, with at least 1 year of service between 2008 and 2017. Subjects were divided into five groups: subjects without ADHD; untreated subjects with ADHD; and subjects with ADHD and prescriptions of 1-90, 91-180, or 181+ tablets during the study period...
August 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30129660/re-foresto-t-song-i-kim-bs-lim-th-2018-stabilization-of-the-lumbar-spine-by-spinal-muscle-forces-producing-compressive-follower-loads-3-dimensional-computational-study
#14
LETTER
Ian A F Stokes, Mack G Gardner-Morse
No abstract text is available yet for this article.
August 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30117192/improved-biomechanics-of-two-alternative-kyphoplasty-cementation-methods-limit-vertebral-recollapse
#15
Todd Alamin, John P Kleimeyer, James R Woodall, Vijay Agarwal, Angus Don, Derek Lindsey
The clinical efficacy of vertebral cement augmentation for compression fractures (VCFs) remains undetermined. Recent studies have shown that refracture and progression of deformity may occur after augmentation with significant clinical consequences. Vertebral body height loss following kyphoplasty has also been observed with cyclic loading. We hypothesized that height loss is partly due to lack of cement fill past the margin of cancellous bone created by balloon expansion with subsequent failure under load...
August 17, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30117189/local-delivery-of-a-zoledronate-solution-improves-osseointegration-of-titanium-implants-in-a-rat-distal-femur-model
#16
Samuel AbuMoussa, David S Ruppert, Christopher Lindsay, Laurence Dahners, Paul Weinhold
This study aimed to determine whether locally applied anti-resorptive agents acetazolamide or zoledronic acid would improve mechanical stability in implant osseointegration when applied as a solution within the medullary canal. Thirty-three rats received titanium-implants bilaterally in their intramedullary femoral canals. Prior to implantation, animals received 0.1 ml saline, 1 mM acetazolamide solution, or 0.7 mM zoledronic acid solution directly into the medullary cavity. The control group only received saline within the medullary canal while the treatment groups only received the respective treatment to which they were randomized...
August 17, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30117186/high-molecular-weight-hyaluronan-protects-cartilage-from-degradation-by-inhibiting-aggrecanase-expression
#17
Takashi Ohtsuki, Keiichi Asano, Junko Inagaki, Akira Shinaoka, Kanae Kumagishi-Shinaoka, Mehmet Zeynel Cilek, Omer Faruk Hatipoglu, Toshitaka Oohashi, Keiichiro Nishida, Issei Komatsubara, Satoshi Hirohata
Hyaluronan is an extracellular matrix component of articular cartilage and has been used to treat patients with osteoarthritis. A disintegrin and metalloproteinases with thrombospondin motifs (ADAMTSs) play an important role in cartilage degradation in osteoarthritis. We have previously reported that ADAMTS4 and ADAMTS9 were induced by cytokine stimulation. However, the effect of hyaluronan on the cytokine-inducible ADAMTS9 has never been investigated. Moreover, it is unclear whether hyaluronan protects cartilage by suppressing aggrecan degradation...
August 17, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30098226/effects-of-sclerotic-changes-on-stress-concentration-in-early-stage-osteonecrosis-a-patient-specific-3d-finite-element-analysis
#18
Takeshi Utsunomiya, Goro Motomura, Satoshi Ikemura, Yusuke Kubo, Kazuhiko Sonoda, Hiroyuki Hatanaka, Shoji Baba, Koichiro Kawano, Takuaki Yamamoto, Yasuharu Nakashima
Stress distribution remains unclear in early-stage osteonecrosis of the femoral head (ONFH). To clarify this issue, we generated patient-specific finite element models (FEMs) from 51 patients with ONFH. Patients' hips were classified into three groups: ONFH without a sclerotic boundary (Stage 1, n = 6), ONFH with a sclerotic boundary (Stage 2, n = 10), and ONFH with both a sclerotic boundary and <2 mm collapse (Stage 3, n = 35). Four hips without ONFH were used as controls. Stress distribution in each FEM was compared with magnetic resonance imaging (MRI) and computed tomography (CT) results...
August 11, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30095195/effect-of-culture-duration-on-chondrogenic-preconditioning-of-equine-bone-marrow-mesenchymal-stem-cells-in-self-assembling-peptide-hydrogel
#19
John D Kisiday, Aimee C Colbath, Suwimol Tangtrongsup
Ex vivo induction of chondrogenesis is a promising approach to improve upon the use of bone marrow mesenchymal stem cells (MSCs) for cartilage tissue engineering. This study evaluated the potential to induce chondrogenesis with days of culture in chondrogenic medium for MSCs encapsulated in self-assembling peptide hydrogel. To simulate the transition from preconditioning culture to implantation, MSCs were isolated from self-assembling peptide hydrogel into an individual cell suspension. Commitment to chondrogenesis was evaluated by seeding preconditioned MSCs into agarose and culturing in the absence of the chondrogenic cytokine transforming growth factor beta (TGFβ)...
August 10, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30084210/genetic-lineage-tracing-of-targeted-cell-populations-during-enthesis-healing
#20
Helen L Moser, Anton P Doe, Kristen Meier, Simon Garnier, Damien Laudier, Haruhiko Akiyama, Matthias A Zumstein, Leesa M Galatz, Alice H Huang
Rotator cuff supraspinatus tendon injuries are clinically challenging due to the high rates of failure after surgical repair. One key limitation to functional healing is the failure to regenerate the enthesis transition between tendon and bone, which heals by disorganized scar formation. Using two models of supraspinatus tendon injury in mouse (partial tear and full detachment/repair), the purpose of the study was to determine functional gait outcomes and identify the origin of the cells that mediate healing...
August 7, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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