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Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society

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https://www.readbyqxmd.com/read/30024053/computational-simulation-of-medial-versus-anteromedial-tibial-tuberosity-transfer-for-patellar-instability
#1
John J Elias, Kerwyn C Jones, Andrew J Copa, Andrew J Cosgarea
The study utilizes dynamic simulation of knee function to determine how tibial tuberosity medialization and anteromedialization influence patellar tracking and contact pressures for knees with patellar instability. Dual limb squatting was simulated with six multibody dynamic simulation models representing knees being treated for patellar instability. Each knee exhibited lateral patellar maltracking in the pre-operative condition based on the bisect offset index. The patellar tendon attachment points on the tibia were medialized by 10 mm to represent tibial tuberosity medialization, with an additional 5 mm of anteriorization applied for anteromedialization...
July 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29999195/transforming-growth-factor-%C3%AE-mediates-communication-of-co-cultured-human-nucleus-pulposus-cells-and-mesenchymal-stem-cells
#2
Tomasz P Lehmann, Głowacki Jakub, Jerzy Harasymczuk, Paweł P Jagodziński
Intervertebral disc (IVD) consists of surrounding tissue annulus fibrosus and central nucleus pulposus, which are partially degenerative in scoliotic IVDs. Successful regeneration of scoliotic alterations requires cognition of critical paracrine mediators of cell-to-cell contact in the IVD. In this work, we hypothesized that transforming growth factor β (TGF-β) is involved in the intercellular communication of nucleus pulposus cells (NPCs) and mesenchymal stem cells (MSCs). We observed that in cultured NPCs TGF-β1 stimulated COL1A1 expression, encoding collagen I, and in MSCs stimulated COL1A1 and SOX9 expressions...
July 12, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29978918/effect-of-counterface-on-cartilage-boundary-lubricating-ability-by-proteoglycan-4-and-hyaluronan-cartilage-glass-vs-cartilage-cartilage
#3
Saleem Abubacker, Allison McPeak, Sam G Dorosz, Philip Egberts, Tannin A Schmidt
The objective of this study was to determine the effect of different sliding interface materials (counterface) on the cartilage lubricating ability of proteoglycan 4 (PRG4) and hyaluronan (HA) by measuring the kinetic coefficient of friction on cartilage-glass and cartilage-cartilage interfaces over a wide range of sliding velocities. The lubrication properties of PRG4 and HA were assessed at cartilage-glass and cartilage-cartilage interfaces using a previously described test setup with a stationary area of contact...
July 6, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29978908/the-role-of-corrosion-in-taper-failure-and-head-disassociation-in-total-hip-arthroplasty-of-a-single-design
#4
Audrey J Martin, Derek R Jenkins, Douglas W Van Citters
Modular junctions have been associated with corrosion in total hip arthroplasty. In a small number of cases, disassociation of the femoral head from the stem following gross wear of the taper has been reported. The purpose of this study was to investigate the role of corrosion in the development of mechanical changes leading to disassociation. Twenty-one retrieved stems and heads of one design previously reported with head disassociation were identified in an IRB-approved database. Components were scored for corrosion and measured for material loss...
July 6, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29978906/mechanical-behaviour-of-metastatic-vertebrae-are-influenced-by-tissue-architecture-mineral-content-and-organic-feature-alterations
#5
Mikhail Burke, Margarete Akens, Alex Kiss, Tom Willett, Cari Whyne
Diminished vertebral mechanical behaviour with metastatic involvement is typically attributed to modified architecture and trabecular bone content. Previous work has identified organic and mineral phase bone quality changes in the presence of metastases, yet limited work exists on the potential influence of such tissue level modifications on vertebral mechanical characteristics. This work seeks to determine correlations between features of bone (structural and tissue level) and mechanical behaviour in metastatically involved vertebral bone...
July 6, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29947434/using-the-scoring-hip-osteoarthritis-with-magnetic-resonance-imaging-shomri-system-to-assess-intra-articular-pathology-in-femoroacetabular-impingement
#6
Trevor Grace, Jan Neumann, Michael A Samaan, Richard B Souza, Sharmila Majumdar, Thomas M Link, Alan L Zhang
There is currently no widely accepted classification system of intra-articular damage in the setting of femoroacetabular impingement (FAI). The goal of this study is to correlate the Scoring Hip Osteoarthritis with Magnetic Resonance Imaging (SHOMRI) system with arthroscopic findings in symptomatic FAI patients to justify its use in this setting. Symptomatic FAI patients scheduled for hip arthroscopy were prospectively enrolled. Prior to surgery, radiographs and an MRI were obtained of the affected hip and all patients completed the Hip disability and Osteoarthritis Outcome Score (HOOS) questionnaire...
June 27, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29947128/trapeziometacarpal-stabilization-through-dorsoradial-ligament-reconstruction-an-early-post-surgery-in-vivo-biomechanical-analyses
#7
Faes D Kerkhof, Evie E Vereecke, Olivier Vanovermeire, Jeroen Vanhaecke, Maarten Vanneste, Filip Stockmans
Ligament reconstruction can provide pain relief in patients with a painful, unstable, pre-arthritic trapeziometacarpal (TMC) joint. Imbrication of the dorsoradial ligament (DRL) has been proposed as a minimal invasive stabilization technique. It requires less invasive surgery than an Eaton-Littler technique and shows promising long-term clinical outcome. We used dynamic CT to objectively review the effects of the imbrication. Four patients with pain and laxity at the TMC joint, but without radiographic signs of osteoarthritis, were recruited...
June 27, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29943463/osteochondral-resurfacing-implantation-angle-is-more-important-than-implant-material-stiffness
#8
A Heuijerjans, W Wilson, K Ito, C C van Donkelaar
Osteochondral resurfacing implants are a promising treatment for focal cartilage defects. Several implant-factors may affect the clinical outcome of this treatment, such as the implant material stiffness and the accuracy of implant placement, known to be challenging. In general, softer implants are expected to be more accommodating for implant misalignment than stiffer implants, and motion is expected to increase effects from implant misalignment and stiffness. 3D finite element models of cartilage/cartilage contact were employed in which implantation angle (0°, 5°, 10°) and implant material stiffness (E= 5 MPa, 100 MPa, 2 GPa) were varied...
June 25, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29926971/transcriptome-profiles-of-isolated-murine-achilles-tendon-proper-and-peritenon-derived-progenitor-cells
#9
Michael J Mienaltowski, Angela Cánovas, Valerie A Fates, Angela R Hampton, Monica Y Pechanec, Alma Islas-Trejo, Juan F Medrano
Progenitor cells of the tendon proper and peritenon have unique properties that could impact their utilization in tendon repair strategies. While a few markers have been found to aid in distinguishing progenitors cells from each region, there is great value in identifying more markers. In this study, we hypothesized that RNAseq could be used to improve our understanding of those markers that define these cell types. Transcriptome profiles were generated for pools of mouse Achilles tendon progenitor cells from both regions and catalogues of potential markers were generated...
June 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29926970/parathyroid-hormone-for-bone-regeneration
#10
REVIEW
Samantha J Wojda, Seth W Donahue
Delayed healing and/or non-union occur in approximately 5-10% of the fractures that occur annually in the United States. Segmental bone loss increases the probability of non-union. Though grafting can be an effective treatment for segmental bone loss, autografting is limited for large defects since a limited amount of bone is available for harvest. Parathyroid hormone (PTH) is a key regulator of calcium homeostasis in the body and plays an important role in bone metabolism. Presently PTH is FDA approved for use as an anabolic treatment for osteoporosis...
June 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29924414/reduction-in-pseudomonas-aeruginosa-and-staphylococcus-aureus-biofilms-from-implant-materials-in-a-diffusion-dominated-environment
#11
James P Moley, Mary S McGrath, Jeffrey F Granger, Paul Stoodley, Devendra H Dusane
Antibiotic-loaded calcium sulfate beads (CS-B) are used to treat biofilm-related periprosthetic joint infections (PJI). A previous study has shown that such beads are effective in reducing lawns biofilms grown on agar plates; however, the ability of CS-B to eradicate biofilms grown on solid orthopaedic material surfaces has not been investigated. We grew biofilms of bioluminescent strains of Pseudomonas aeruginosa Xen41 and a USA300 MRSA Staphylococcus aureus SAP231 on ultra-high molecular weight polyethylene (PE), hydroxyapatite (HA), and 316L stainless steel (SS) coupons for three days under static growth conditions, with daily nutrient exchange...
June 20, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29920765/gait-analysis-related-to-functional-outcome-in-patients-operated-for-ankle-fractures
#12
Sander van Hoeve, Michael Houben, Jan P A M Verbruggen, Paul Willems, Kenneth Meijer, Martijn Poeze
Ankle fractures are among the most common lower limb fractures. Associations between postoperative radiographic results and clinical outcome have been found, but less is known about the relevant ankle biomechanics. This study analysed ankle kinematics, radiographic findings and patient-reported outcome measures (PROM) in patients treated for ankle fractures. The hypothesis was that patients after ankle fracture surgery had less flexion/extension in the ankle compared to healthy subjects and that fracture severity had significant influence on kinematics and patient satisfaction...
June 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29917272/enhancing-the-effects-of-exfoliated-carbon-nanofibers-using-bone-morphogenetic-protein-in-a-rat-spinal-fusion-model
#13
Naoki Notani, Masashi Miyazaki, Masahiro Toyoda, Shozo Kanezaki, Toshinobu Ishihara, Hiroshi Tsumura
Exfoliated carbon nanofibers (ExCNFs) are expected to serve as excellent scaffolds for promoting and guiding bone-tissue regeneration. We aimed to enhance the effects of ExCNFs using bone morphogenetic proteins (BMPs) and examined their feasibility and safety in clinical applications using a rat spinal fusion model. Group I (n = 15) animals were implanted with the control carrier; Group II (n = 16) animals were implanted with carrier containing 1 μg ExCNFs; Group III (n = 16) animals were implanted with carrier containing 1 μg recombinant human (rh) BMP-2; and Group IV (n = 17) animals were implanted with carrier containing 1 μg rhBMP-2 and 1 μg ExCNFs...
June 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29917270/lagloc-a-new-surgical-technique-for-locking-plate-systems
#14
Miguel Triana, Boyko Gueorguiev, Christoph Sommer, Karl Stoffel, Yash Agarwal, Ivan Zderic, Tobias Helfen, James C Krieg, Fabian Krause, Matthias Knobe, R Geoff Richards, Mark Lenz
Treatment of oblique and spiral fractures remains challenging. The aim of this study was to introduce and investigate the new LagLoc technique for locked plating with generation of interfragmentary compression, combining the advantages of lag-screw and locking-head-screw techniques. Oblique fracture was simulated in artificial diaphyseal bones, assigned to three groups for plating with a 7-hole locking compression plate. Group I was plated with three locking screws in holes 1, 4 and 7. The central screw crossed the fracture line...
June 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29917267/investigating-gender-and-ethnicity-differences-in-proximal-humeral-morphology-using-a-statistical-shape-model
#15
Irene Sintini, William S Burton, Paul Sade, Jason M Chavarria, Peter J Laz
Morphological variability in the shoulder influences the joint biomechanics and is an important consideration in arthroplasty and implant design. The objectives of this study were to quantify cortical and cancellous proximal humeral morphology and to assess whether shape variation was influenced by gender and ethnicity, with the overarching goal of informing implant design and treatment. A statistical shape model of the proximal humeral cortical and cancellous regions was developed for a training set of 84 subjects of both genders and different ethnicities...
June 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29917265/multi-objective-design-optimization-of-high-tibial-osteotomy-for-improvement-of-biomechanical-effect-by-using-finite-element-analysis
#16
Yong-Gon Koh, Juhyun Son, Ho-Joong Kim, Sae Kwang Kwon, Oh-Ryong Kwon, Hyo Jeong Kim, Kyoung-Tak Kang
Medial opening wedge high tibial osteotomy (HTO) makes the proximal tibia a highly unstable structure and causes plates and screws to be the potential sources for mechanical failure. However, asymmetrical callus and incomplete bone formations underneath the plates (TomoFix) have been recent concerns in clinical and experimental studies related to HTO due to the high stiffness. The purpose of this study was to evaluate the biomechanical effect of the TomoFix plate system with respect to changes in design using a computational simulation...
June 19, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29901247/joint-contracture-is-reduced-by-intra-articular-implantation-of-rosiglitazone-loaded-hydrogels-in-a-rabbit-model-of-arthrofibrosis
#17
Diren Arsoy, Christopher G Salib, William H Trousdale, Meagan E Tibbo, Afton K Limberg, Anthony Viste, Eric A Lewallen, Nicolas Reina, Michael J Yaszemski, Daniel J Berry, Andre J van Wijnen, Mark E Morrey, Joaquin Sanchez-Sotelo, Matthew P Abdel
Trauma, surgery, and other inflammatory conditions can lead to debilitating joint contractures. Adjunct pharmacologic modalities may permit clinical prevention and treatment of recalcitrant joint contractures. We investigated the therapeutic potential of rosiglitazone by intra-articular delivery via oligo[poly(ethylene glycol)fumarate] (OPF) hydrogels in an established rabbit model of arthrofibrosis. OPF hydrogels loaded with rosiglitazone were characterized for drug elution properties upon soaking in minimum essential media (MEM) with 10% fetal bovine serum and measurements of drug concentrations via High Performance Liquid Chromatography (HPLC)...
June 14, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29901228/ultrastructure-of-tendon-rupture-depends-on-strain-rate-and-tendon-type
#18
Neil C Chambers, Tyler W Herod, Samuel P Veres
Previous research has shown that both the mechanics and elongation mechanisms of tendon and ligament vary with strain rate during tensile loading. In this study, we sought to determine if the ultrastructural damage created during tendon rupture also varies with strain rate. A bovine forelimb model was used, allowing two anatomically proximate but physiologically distinct tendons to be studies: the positional common digital extensor tendon, and the energy storing superficial digital flexor tendon. Samples from the two tendon types were ruptured at rates of either 1%/s or 10%/s...
June 14, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29888808/changes-in-proinflammatory-cytokines-neuropeptides-and-microglia-in-an-animal-model-of-monosodium-iodoacetate-induced-hip-osteoarthritis
#19
Yuya Kawarai, Sumihisa Orita, Junichi Nakamura, Shuichi Miyamoto, Miyako Suzuki, Kazuhide Inage, Shigeo Hagiwara, Takane Suzuki, Takayuki Nakajima, Tsutomu Akazawa, Seiji Ohtori
The aim of this study was to investigate the local production of proinflammatory cytokines, pain-related sensory innervation of dorsal-root ganglia (DRG), and spinal changes in a rat model of induced hip osteoarthritis (OA). Seventy-five Sprague-Dawley rats were used, including 25 controls and 50 injected into the right hip joints (sham group, injected with 25 µl of sterile saline: N = 25; and monosodium iodoacetate (MIA) group, injected with 25 µl of sterile saline with 2 mg of MIA: N = 25)...
June 11, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29877577/osteoclast-related-markers-in-the-hip-joint-fluid-with-subchondral-insufficiency-fracture-of-the-femoral-head
#20
Yusuke Kubo, Goro Motomura, Satoshi Ikemura, Hiroyuki Hatanaka, Jun-Ichi Fukushi, Satoshi Hamai, Takuaki Yamamoto, Yasuharu Nakashima
Similar to the radiological findings in rapidly destructive arthrosis of the hip joint (RDA), subchondral insufficiency fracture of the femoral head (SIF) can result in progressive femoral head collapse of unknown etiology. We thus examined the osteoclast activity of hip joint fluid in SIF with progressive collapse in comparison with that in RDA. Twenty-nine hip joint fluid samples were obtained intraoperatively with whole femoral heads from 12 SIF patients and 17 RDA patients. SIF cases were classified into subgroups based on the presence of ≥2 mm collapse on preoperative radiographs: SIF with progressive collapse (n = 5) and SIF without progressive collapse (n = 7)...
June 7, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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