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Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society

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https://www.readbyqxmd.com/read/28731271/ultrasound-elastography-for-carpal-tunnel-pressure-measurement-a-cadaveric-validation-study
#1
Kazutoshi Kubo, Boran Zhou, Yu-Shiuan Cheng, Tai-Hua Yang, Bo Qiang, Kai-Nan An, Steven L Moran, Peter C Amadio, Xiaoming Zhang, Chunfeng Zhao
Carpal tunnel pressure is a key factor in the etiology of carpal tunnel syndrome. Numerous approaches have been conducted to measure carpal tunnel pressure. However, most techniques are invasive and take time and effort. We have developed an innovative approach to noninvasively assess the tunnel pressure by using the ultrasound surface wave elastography (USWE) technique. In a previous study it was shown that the shear wave speed in a tendon increased linearly with increasing tunnel pressure enclosed the tendon in a simple tendon model...
July 21, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28722281/collagen-organization-regulates-stretch-initiated-pain-related-neuronal-signals-in-vitro-implications-for-structure-function-relationships-in-innervated-ligaments
#2
Sijia Zhang, Sagar Singh, Beth A Winkelstein
Injury to the spinal facet capsule, an innervated ligament with heterogeneous collagen organization, produces pain. Although mechanical facet joint trauma activates embedded afferents, it is unclear if, and how, the varied extracellular microstructure of its ligament affects sensory transduction for pain from mechanical inputs. To investigate the effects of macroscopic deformations on afferents in collagen matrices with different organizations, an in vitro neuron-collagen construct (NCC) model was used. NCCs with either randomly organized or parallel aligned collagen fibers were used to mimic the varied microstructure in the facet capsular ligament...
July 19, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28722231/bacteria-antibiotic-resistance-new-challenges-and-opportunities-for-implant-associated-orthopaedic-infections
#3
Bingyun Li, Thomas J Webster
There has been a dramatic increase in the emergence of antibiotic resistant bacterial strains, which has made antibiotic choices for infection control increasingly limited and more expensive. In the U.S. alone, antibiotic resistant bacteria cause at least 2 million infections and 23,000 deaths a year resulting in a $55-70 billion per year economic impact. Antibiotics are critical to the success of surgical procedures including orthopaedic prosthetic surgeries, and antibiotic resistance is occurring in nearly all bacteria that infect people, including the most common bacteria that cause orthopaedic infections, such as Staphylococcus aureus (S...
July 19, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28718947/relevance-of-bioreactors-and-whole-tissue-cultures-for-the-translation-of-new-therapies-to-humans
#4
Marianna Peroglio, Diana Gaspar, Dimitrios I Zeugolis, Mauro Alini
The purpose of this review is to provide a brief overview of bioreactor-based culture systems as alternatives to conventional two- and three- dimensional counterparts. The role, challenges and future aspirations of bioreactors in the musculoskeletal field (e.g. cartilage, intervertebral disc, tendon and bone) are discussed. Bioreactors, by recapitulating physiological processes, can be used effectively as part of the initial in vitro screening, reducing that way the number of animal required for preclinical assessment, complying with the 3R principles and, in most cases, allowing working with human tissues...
July 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28708309/bone-healing-in-an-aged-murine-fracture-model-is-characterized-by-sustained-callus-inflammation-and-decreased-cell-proliferation
#5
John H Hebb, Jason W Ashley, Lee McDaniel, Luke A Lopas, John Tobias, Kurt D Hankenson, Jaimo Ahn
Geriatric fractures take longer to heal and heal with more complications than those of younger patients; however, the mechanistic basis for this difference in healing is not well understood. To improve this understanding, we investigated cell and molecular differences in fracture healing between 5 month-old (young adult) and 25 month-old (geriatric) mice healing utilizing high-throughput analysis of gene expression. Mice underwent bilateral tibial fractures and fracture calluses were harvested at 5, 10, and 20 days post fracture (DPF) for analysis...
July 14, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28708301/quantification-of-interfacial-motions-following-primary-and-revision-total-knee-arthroplasty-a-verification-study-versus-experimental-data
#6
Noel Conlisk, Colin R Howie, Pankaj Pankaj
Motion at the bone-implant interface, following primary or revision knee arthroplasty, can be detrimental to the long term survival of the implant. This study employs experimentally verified computational models of the distal femur to characterise the relative motion at the bone-implant interface for three different implant types; a posterior stabilising implant (PS), a total stabilising implant (TS) with short stem (12mm x 50mm), and a total stabilising implant (TS) with long offset stem (19mm x 150mm with a 4mm lateral offset)...
July 14, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28708287/regulation-of-rankl-induced-osteoclastogenesis-by-ring-finger-protein-rnf114
#7
Boren Lin, Qi Ke, Douglas W Leaman, Vijay Goel, Anand Agarwal
Normal bone remodeling is a continuous process orchestrated by bone-resorbing osteoclasts and bone-forming osteoblasts, which an imbalance in bone remodeling results in metabolic bone diseases. RANKL, a member of the TNF cytokine family, functions as a key stimulator for osteoclast differentiation and maturation. Here, we report that RNF114, previously identified as a psoriasis susceptibility gene, plays a regulatory role in the RANKL/RANK/TRAF6 signaling pathway that mediates osteoclastogenesis. Our results demonstrated that RNF114 expression was significantly down-regulated in mouse osteoclast precursor cells undergoing RANKL-induced osteoclast differentiation...
July 14, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28696002/mitochondrial-dysfunction-is-an-acute-response-of-articular-chondrocytes-to-mechanical-injury
#8
Michelle L Delco, Edward D Bonnevie, Lawrence J Bonassar, Lisa A Fortier
Mitochondrial (MT) dysfunction is known to occur in chondrocytes isolated from end-stage osteoarthritis (OA) patients, but the role of MT dysfunction in the initiation and early pathogenesis of post-traumatic OA (PTOA) remains unclear. The objective of this study was to investigate chondrocyte MT function immediately following mechanical injury in cartilage, and to determine if the response to injury differed between a weight bearing region (medial femoral condyle; MFC) and a non-weight bearing region (distal patellofemoral groove; PFG) of the same joint...
July 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28688215/alterations-in-structural-macromolecules-and-chondrocyte-deformations-in-lapine-retropatellar-cartilage-nine-weeks-after-anterior-cruciate-ligament-transection
#9
Sang-Kuy Han, Ari Ronkainen, Simo Saarakkala, Lassi Rieppo, Walter Herzog, Rami K Korhonen
The structural integrity and mechanical environment of the articular cartilage matrix directly affect chondrocyte deformations. Rabbit models of early osteoarthritis at nine weeks following anterior cruciate ligament transection (ACLT) have been shown to alter the deformation behaviour of superficial zone chondrocytes in mechanically loaded articular cartilage. However, it is not fully understood whether these changes in cell mechanics are caused by changes in structural macromolecules in the extracellular matrix...
July 8, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28688198/study-of-the-interactions-between-proximal-femur-3d-bone-shape-cartilage-health-and-biomechanics-in-patients-with-hip-osteoarthritis
#10
Valentina Pedoia, Michael A Samaan, Gaurav Inamdar, Matthew C Gallo, Richard B Souza, Sharmila Majumdar
In this study quantitative MRI and gait analysis were used to investigate the relationships between proximal femur 3D bone shape, cartilage morphology, cartilage biochemical composition, and joint biomechanics in subject with hip Osteoarthritis (OA). Eighty subjects underwent unilateral hip MR-imaging: T1ρ and T2 relaxation times were extracted through voxel based relaxometry and bone shape was assessed with 3D MRI-based statistical shape modeling. In addition, 3D gait analysis was performed in seventy-six of the studied subjects...
July 8, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28685857/biomechanical-simulations-of-costo-vertebral-and-anterior-vertebral-body-tethers-for-the-fusionless-treatment-of-pediatric-scoliosis
#11
Carl-Éric Aubin, Julien Clin, Jeremy Rawlinson
Compression-based fusionless tethers are an alternative to conventional surgical treatments of pediatric scoliosis. Anterior approaches place an anterior (ANT) tether on the anterolateral convexity of the deformed spine to modify growth. Posterior, or costo-vertebral (CV), approaches have not been assessed for biomechanical and corrective effectiveness. The objective was to biomechanically assess CV and ANT tethers using six patient-specific, finite element models of adolescent scoliotic patients (11.9 ± 0...
July 7, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28682003/impact-insertion-of-osteochondral-grafts-interference-fit-and-central-graft-reduction-affect-biomechanics-and-cartilage-damage
#12
Alvin W Su, Yunchan Chen, Dustin H Wailes, Van W Wong, Shengqiang Cai, Albert C Chen, William D Bugbee, Robert L Sah
An osteochondral graft (OCG) is an effective treatment for articular cartilage and osteochondral defects. Impact of an OCG during insertion into the osteochondral recipient site (OCR) can cause chondrocyte death and matrix damage. The aim of the present study was to analyze the effects of graft-host interference fit and a modified OCG geometry on OCG insertion biomechanics and cartilage damage. The effects of interference fit (radius of OCG - radius of OCR), loose (0.00mm), moderate (0.05mm), tight (0.10mm), and of a tight fit with OCG geometry modification (central region of decreased radius) were analyzed for OCG cylinders and OCR blocks from adult bovine knee joints with an instrumented drop tower apparatus...
July 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28681971/growth-plate-expression-profiling-large-and-small-breed-dogs-provide-new-insights-in-endochondral-bone-formation
#13
Michelle Teunissen, Frank M Riemers, Dik van Leenen, Marian J A Groot Koerkamp, Björn P Meij, Jacqueline Alblas, Louis C Penning, Alberto Miranda-Bedate, Marianna A Tryfonidou
The difference in the adult height of mammals, and hence in endochondral bone formation, is not yet fully understood and may serve to identify targets for bone and cartilage regeneration. In line with this hypothesis, the intra-species disparity between the adult height of Great Danes and Miniature Poodles was investigated at a transcriptional level. Microarray analysis of the growth plate of 5 Great Danes and 5 Miniature Poodles revealed 2981 unique genes that were differentially expressed, including many genes with an unknown role in skeletal development...
July 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28681967/augmentation-of-fracture-healing-by-hydroxyapatite-collagen-paste-and-bone-morphogenetic-protein-2-evaluated-using-a-rat-femur-osteotomy-model
#14
Xuetao Wei, Satoru Egawa, Renpei Matsumoto, Hiroaki Yasuda, Keigo Hirai, Toshitaka Yoshii, Atsushi Okawa, Takehiko Nakajima, Shinichi Sotome
In fracture treatment, biological bone union generally depends on the bone's natural fracture healing capacity, even in surgically treated cases. Hydroxyapatite/collagen composite (HAp/Col) has high osteoconductivity and stimulates osteogenic progenitors. Furthermore, it has the potent capacity to adsorb bone morphogenetic proteins (BMPs). In this study, we prepared an injectable HAp/Col paste and evaluated its augmentation of bone union. Furthermore, the effect of HAp/Col paste combined with BMP-2 was also evaluated...
July 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28671352/transcriptional-profiling-of-articular-cartilage-in-a-porcine-model-of-early-post-traumatic-osteoarthritis
#15
Jakob T Sieker, Benedikt L Proffen, Kimberly A Waller, Kaitlyn E Chin, Naga P Karamchedu, Matthew R Akelman, Gabriel S Perrone, Ata M Kiapour, Johannes Konrad, Martha M Murray, Braden C Fleming
To identify the molecular pathophysiology present in early post-traumatic osteoarthritis (PTOA), the transcriptional profile of articular cartilage and its response to surgical PTOA induction were determined. 36 Yucatan minipigs underwent anterior cruciate ligament (ACL) transection and were randomly assigned in equal numbers to no further treatment, reconstruction or ligament repair. Cartilage was harvested at 1 and 4 weeks post-operatively and histology and RNA-sequencing were performed and compared to controls...
July 3, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28667799/reduced-bone-loss-in-a-murine-model-of-postmenopausal-osteoporosis-lacking-complement-component-3
#16
Danielle L MacKay, Thomas J Kean, Kristina G Bernardi, Heather S Haeberle, Catherine G Ambrose, Feng Lin, James E Dennis
The growing field of osteoimmunology seeks to unravel the complex interdependence of the skeletal and immune systems. Notably, we and others have demonstrated that complement signaling influences the differentiation of osteoblasts and osteoclasts, the two primary cell types responsible for maintaining bone homeostasis. However, the net effect of complement on bone homeostasis in vivo was unknown. Our published in vitro mechanistic work led us to hypothesize that absence of complement component 3 (C3), a central protein in the complement activation cascade, protects against bone loss in the ovariectomy-based model of postmenopausal osteoporosis...
July 1, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28660712/reverse-engineering-development-crosstalk-opportunities-between-developmental-biology-and-tissue-engineering
#17
Ralph S Marcucio, Ling Qin, Eben Alsberg, Joel D Boerckel
The fields of developmental biology and tissue engineering have been revolutionized in recent years by technological advancements, expanded understanding, and biomaterials design, leading to the emerging paradigm of "developmental" or "biomimetic" tissue engineering. While developmental biology and tissue engineering have long overlapping histories, the fields have largely diverged in recent years at the same time that crosstalk opportunities for mutual benefit are more salient than ever. In this perspective article, we will use musculoskeletal development and tissue engineering as a platform on which to discuss these emerging crosstalk opportunities and will present our opinions on the bright future of these overlapping spheres of influence...
June 29, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28657192/the-effects-of-age-and-pathology-on-shear-wave-speed-of-the-human-rotator-cuff
#18
Timothy G Baumer, Jack Dischler, Leah Davis, Yassin Labyed, Daniel S Siegal, Marnix van Holsbeeck, Vasilios Moutzouros, Michael J Bey
Rotator cuff tears are common and often repaired surgically, but post-operative repair tissue healing and shoulder function can be unpredictable. Tear chronicity is believed to influence clinical outcomes, but conventional clinical approaches for assessing tear chronicity are subjective. Shear wave elastography (SWE) is a promising technique for assessing soft tissue via estimates of shear wave speed (SWS), but this technique has not been used extensively on the rotator cuff. Specifically, the effects of age and pathology on rotator cuff SWS are not well known...
June 28, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28657154/tissue-engineered-tendon-constructs-for-rotator-cuff-repair-in-sheep
#19
Stoyna S Novakova, Vasudevan D Mahalingam, Shelby E Florida, Christopher L Mendias, Answorth Allen, Ellen M Arruda, Asheesh Bedi, Lisa M Larkin
Current rotator cuff repair commonly involves the use of single or double row suture techniques, and despite successful outcomes, failure rates continue to range from 20-95%. Failure to regenerate native biomechanical properties at the enthesis is thought to contribute to failure rates. Thus, the need for technologies that improve structural healing of the enthesis after rotator cuff repair is imperative. To address this issue, our lab has previously demonstrated enthesis regeneration using a tissue-engineered graft approach in a sheep anterior cruciate ligament (ACL) repair model...
June 28, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28653780/gait-training-for-chronic-ankle-instability-improves-neuromechanics-during-walking
#20
Mark A Feger, Joseph M Hart, Susan Saliba, Mark F Abel, Jay Hertel
A novel gait-training device has been shown to improve gait patterns while patients with chronic ankle instability (CAI) are using the device and our current objective was to analyze the effect of structured gait training with the device on plantar pressure and surface electromyography (sEMG) following repeated gait training sessions. Sixteen CAI patients participated. Plantar pressure and sEMG were collected simultaneously during walking pre- and post-gait training. Plantar pressure (pressure time integral, peak pressure, time to peak pressure, contact area, contact time and center of pressure trajectory) of the entire foot and 9 specific regions of the foot were recorded concurrently with sEMG root mean square amplitudes from the anterior tibialis, peroneus longus, medial gastrocnemius, and gluteus medius...
June 27, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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