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Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society

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https://www.readbyqxmd.com/read/28098396/the-effects-of-chronic-cobalt-and-chromium-exposure-after-metal-on-metal-hip-resurfacing-an-epigenome-wide-association-pilot-study
#1
Julia Steinberg, Karan M Shah, Alison Gartland, Eleftheria Zeggini, J Mark Wilkinson
Metal-on-metal (MOM) hip resurfacing has recently been a popular prosthesis choice for the treatment of symptomatic arthritis, but results in the release of cobalt and chromium ions into the circulation that can be associated with adverse clinical effects. The mechanism underlying these effects remains unclear. While chromosomal aneuploidy and translocations are associated with this exposure, the presence of subtle structural epigenetic modifications in patients with MOM joint-replacements remains unexplored...
January 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28092118/incorporation-of-ct-based-measurements-of-trunk-anatomy-into-subject-specific-musculoskeletal-models-of-the-spine-influences-vertebral-loading-predictions
#2
Alexander G Bruno, Hossein Mokhtarzadeh, Brett T Allaire, Kelsey R Velie, M Clara De Paolis Kaluza, Dennis E Anderson, Mary L Bouxsein
We created subject-specific musculoskeletal models of the thoracolumbar spine by incorporating spine curvature and muscle morphology measurements from computed tomography (CT) scans to determine the degree to which vertebral compressive and shear loading estimates are sensitive to variations in trunk anatomy. We measured spine curvature and trunk muscle morphology using spine CT scans of 125 men, and then created four different thoracolumbar spine models for each person: 1) height and weight adjusted (Ht/Wt models); 2) height, weight and spine curvature adjusted (+C models); 3) height, weight and muscle morphology adjusted (+M models); and 4) height, weight, spine curvature, and muscle morphology adjusted (+CM models)...
January 16, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28090663/response-from-the-authors-re-nathan-d-schilaty-nathaniel-a-bates-timothy-e-hewett-letter-to-the-editor-effect-of-sagittal-plane-mechanics-on-acl-strain-during-jump-landing
#3
LETTER
Ryan Bakker, Sebastian Tomescu, Elora Brenneman, Gajendra Hangalur, Andrew Laing, Naveen Chandrashekar
We thank the authors of the letter (1) for their comments regarding our paper "Effect of Sagittal Plane Mechanics on ACL Strain during Jump Landing"(2) . Breaking apart the fundamental influencers of ACL strain and injury is difficult, in part due to the multitude of variables involved. Research studying these interconnected variables increases the experimental complexity required for biofidelic experimental setups. This article is protected by copyright. All rights reserved.
January 16, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28090661/letter-to-the-editor-effect-of-sagittal-plane-mechanics-on-acl-strain-during-jump-landing
#4
LETTER
Nathan D Schilaty, Nathaniel A Bates, Timothy E Hewett
We read with great interest the article entitled, "Effect of Sagittal Plane Mechanics on ACL Strain During Jump Landing" by Bakker et al.(1) We congratulate the authors for their complex study design that utilized the in sim approach(2) that is designed to cross-correlate the complex results of in vivo, in vitro, and in silico research approaches. The published study adds information in regards to potential models of the mechanisms of ACL injury to the body of literature. This article is protected by copyright...
January 16, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28084668/the-humeral-head-circle-fit-method-greatly-increases-reliability-and-accuracy-when-measuring-anterior-posterior-radiographs-of-the-proximal-humerus
#5
Chad S Mears, Tanner D Langston, Colton M Phippen, Wayne Z Burkhead, John G Skedros
Measurements made on routine A-P radiographs can predict strength/quality of the proximal humerus, as shown in terms of two easy-to-measure parameters: cortical index (CI) and mean-combined cortical thickness (MCCT). Because of high variability inherent when using established methods to measure these parameters, we describe a new orientation system. Using digitized radiographs of 33 adult proximal humeri, five observers measured anatomical reference locations in accordance with: (1) Tingart et al. (2003) method, (2) Mather et al...
January 13, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28084655/effects-of-local-vanadium-delivery-on-diabetic-fracture-healing
#6
Joseph Ippolito, Ethan S Krell, Jessica Cottrell, Ryan Meyer, Devin Clark, Daniel Nguyen, Suleiman Sudah, Maximillian Muñoz, Elisha Lim, Anthony Lin, T J Lee, J Patrick O'Connor, Joseph Benevenia, Sheldon S Lin
This study evaluated the effect of local vanadyl acetylacetonate (VAC), an insulin mimetic agent, upon the early and late parameters of fracture healing in rats using a standard femur fracture model. Mechanical testing, and radiographic scoring were performed, as well as histomorphometry, including percent bone, percent cartilage, and osteoclast numbers. Fractures treated with local 1.5mg/kg VAC possessed significantly increased mechanical properties compared to controls at 6 weeks post-fracture, including increased torque to failure (15%; p = 0...
January 13, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28084653/predicting-early-symptomatic-osteoarthritis-in-the-human-knee-using-machine-learning-classification-of-magnetic-resonance-images-from-the-osteoarthritis-initiative
#7
Beth G Ashinsky, Mustapha Bouhrara, Christopher E Coletta, Benoit Lehallier, Kenneth L Urish, Ping-Chang Lin, Ilya G Goldberg, Richard G Spencer
The purpose of this study is to evaluate the ability of a machine learning algorithm to classify in vivo magnetic resonance images (MRI) of human articular cartilage for development of osteoarthritis (OA). Sixty-eight subjects were selected from the Osteoarthritis Initiative (OAI) control and incidence cohorts. Progression to clinical OA was defined by the development of symptoms as quantified by the Western Ontario and McMaster Universities Arthritis (WOMAC) questionnaire three years after baseline evaluation...
January 13, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28079273/abnormal-fetal-muscle-forces-result-in-defects-in-spinal-curvature-and-alterations-in-vertebral-segmentation-and-shape
#8
Rebecca A Rolfe, James H Bezer, Tyler Kim, Ahmed Z Zaidon, Michelle L Oyen, James C Iatridis, Niamh C Nowlan
The incidence of congenital spine deformities, including congenital scoliosis, kyphosis and lordosis, may be influenced by the in utero mechanical environment, and particularly by fetal movements at critical time-points. There is a limited understanding of the influence of fetal movements on spinal development, despite the fact that mechanical forces have been shown to play an essential role in skeletal development of the limb. This study investigates the effects of muscle forces on spinal curvature, vertebral segmentation and vertebral shape by inducing rigid or flaccid paralysis in the embryonic chick...
January 12, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28075046/a-standardized-fluoroscopy-based-technique-to-measure-intraoperative-cup-anteversion
#9
Matthieu Zingg, Sana Boudabbous, Didier Hannouche, Xavier Montet, Friedrich Boettner
Direct anterior approach (DAA) with the patient lying supine has facilitated the use of intraoperative fluoroscopy and allows for standardized positioning of the patient. The current study presents a new technique to measure acetabular component anteversion using intraoperative fluoroscopy. The current paper describes a mathematical formula to calculate true acetabular component anteversion based on the acetabular component abduction angle and the c-arm tilt angle (CaT). The CaT is determined by tilting the c-arm until an external pelvic oblique radiograph with the equatorial plane of the acetabular component perpendicular to the fluoroscopy receptor is obtained...
January 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28071819/evidence-that-interfibrillar-load-transfer-in-tendon-is-supported-by-small-diameter-fibrils-and-not-extrafibrillar-tissue-components
#10
Spencer E Szczesny, Kristen L Fetchko, George R Dodge, Dawn M Elliott
Collagen fibrils in tendon are believed to be discontinuous and transfer tensile loads through shear forces generated during interfibrillar sliding. However, the structures that transmit these interfibrillar forces are unknown. Various extrafibrillar tissue components (e.g., glycosaminoglycans, collagens XII and XIV) have been suggested to transmit interfibrillar loads by bridging collagen fibrils. Alternatively, collagen fibrils may interact directly through physical fusions and interfibrillar branching. The objective of this study was to test whether extrafibrillar proteins are necessary to transmit load between collagen fibrils or if interfibrillar load transfer is accomplished directly by the fibrils themselves...
January 10, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28071815/effect-of-glenohumeral-elevation-on-subacromial-supraspinatus-compression-risk-during-simulated-reaching
#11
Rebekah L Lawrence, Dustin M Schlangen, Katelyn A Schneider, Jonathan Schoenecker, Andrea L Senger, William C Starr, Justin L Staker, Jutta M Ellermann, Jonathan P Braman, Paula M Ludewig
Mechanical subacromial rotator cuff compression is one theoretical mechanism in the pathogenesis of rotator cuff disease. However, the relationship between shoulder kinematics and mechanical subacromial rotator cuff compression across the range of humeral elevation motion is not well understood. The purpose of this study was to investigate the effect of humeral elevation on subacromial compression risk of the supraspinatus during a simulated functional reaching task. Three-dimensional anatomical models were reconstructed from shoulder magnetic resonance images acquired from 20 subjects (10 asymptomatic, 10 symptomatic)...
January 10, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28071813/sex-differences-in-tendon-structure-and-function
#12
Dylan C Sarver, Yalda Ashraf Kharaz, Kristoffer B Sugg, Jonathan P Gumucio, Eithne Comerford, Christopher L Mendias
Tendons play a critical role in the transmission of forces between muscles and bones, and chronic tendon injuries and diseases are among the leading causes of musculoskeletal disability. Little is known about sex-based differences in tendon structure and function. Our objective was to evaluate the mechanical properties, biochemical composition, transcriptome, and cellular activity of plantarflexor tendons from four month old male and female C57BL/6 mice using in vitro biomechanics, mass spectrometry-based proteomics, genome-wide expression profiling, and cell culture techniques...
January 10, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28059475/reducing-uncertainty-when-using-knee-specific-finite-element-models-by-assessing-the-effect-of-input-parameters
#13
Hongqiang Guo, Thomas J Santner, Amy L Lerner, Suzanne A Maher
Little is known about knee-specific factors that influence contact mechanics. Finite Element (FE) models offer a powerful tool to study contact mechanics, but there often exists ambiguity in the exact values of the inputs (tissue properties, for example), which can result in a range of output values. Our objective was to quantify the reduction in the range of output values (defined herein as "uncertainty") from FE models of the human knee joint when known pre-defined values are used for clinically measurable inputs...
January 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28054384/computational-anatomy-of-the-dens-axis-evaluated-by-quantitative-computed-tomography-implications-for-anterior-screw-fixation
#14
Dominic Gehweiler, Dirk Wähnert, Norbert Meier, Maarten Spruit, Michael Johannes Raschke, Robert Geoff Richards, Hansrudi Noser, Lukas Kamer
The surgical fracture fixation of the odontoid process (dens) of the second cervical vertebra (C2/axis) is a challenging procedure, particularly in elderly patients affected by bone loss, and includes screw positioning close to vital structures. The aim of this study was to provide an extended anatomical knowledge of C2, the bone mass distribution and bone loss, and to understand the implications for anterior screw fixation. 120 standard clinical quantitative computed tomography (QCT) scans of the intact cervical spine from 60 female and 60 male European patients, aged 18-90 years, were used to compute a three-dimensional statistical model and an averaged bone mass model of C2...
January 5, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28052440/positive-outcomes-following-gait-therapy-intervention-for-hip-osteoarthritis-a-longitudinal-study
#15
Deborah Solomonow-Avnon, Amir Herman, Daniel Levin, Nimrod Rozen, Eli Peled, Alon Wolf
: Footwear-generated biomechanical manipulation of lower-limb joints was shown to beneficially impact gait and quality of life in knee osteoarthritis patients, but has not been tested in hip osteoarthritis patients. We examined a customized gait treatment program using a biomechanical device shown in previous investigations to be capable of manipulating hip biomechanics via foot center of pressure (COP) modulation. The objective of this study was to assess the treatment program for hip osteoarthritis patients, enrolled in a 1-year prospective investigation, by means of objective gait and spatiotemporal parameters, and subjective quality of life measures...
January 4, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28052435/lumbar-spine-postures-in-marines-during-simulated-operational-positions
#16
David B Berry, Ana E Rodríguez-Soto, J Su, Sara P Gombatto, Bahar Shahidi, Laura Palombo, Christine Chung, Andrew Jensen, Karen R Kelly, Samuel R Ward
Low back pain has a 70% higher prevalence in members of the armed forces than in the general population, possibly due to the loads and positions soldiers experience during training and combat. Although the influence of heavy load carriage on standing lumbar spine posture in this population is known, postures in other operationally relevant positions are unknown. Therefore, the purpose of this study was to characterize the effect of simulated military operational positions under relevant loading conditions on global and local lumbar spine postures in active duty male US Marines...
January 4, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28019703/a-clinically-relevant-hydrogel-based-on-hyaluronic-acid-and-platelet-rich-plasma-as-a-carrier-for-mesenchymal-stem-cells-rheological-and-biological-characterization
#17
Gianluca Vadalà, Fabrizio Russo, Maria Musumeci, Matteo D'Este, Caterina Cattani, Giuseppina Catanzaro, Maria Cristina Tirindelli, Lorenza Lazzari, Mauro Alini, Rosaria Giordano, Vincenzo Denaro
Intervertebral disc regeneration is quickly moving towards clinical applications. However, it is still missing an ideal injectable hydrogel to support mesenchymal stem cells (MSC) delivery. Herein, a new injectable hydrogel composed of platelet rich plasma (PRP) and hyaluronic acid (HA) blended with batroxobin (BTX) as gelling agent, was designed to generate a clinically relevant cell carrier for disc regeneration. PRP/HA/BTX blend was tested for rheological properties. Amplitude sweep, frequency sweep and rotational measurements were performed and viscoelastic properties were evaluated...
December 26, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28012199/who-or-what-controls-tendon
#18
Dianne Little
There are many ways that the tendon phenotype within an individual animal responds to the loading and host environment to which it is subjected, and none occur as an isolated process; rather through integration of mechanotransduction, complex interactions between anabolic and catabolic protein-protein interactions; and through interplay between different RNA species to modulate gene and protein expression. These processes are generally considered to be the integrated response of the tendon organ to the local environment within the host, or 'The Who'...
December 24, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28004425/angiopoietin-like-4-a-molecular-link-between-insulin-resistance-and-rheumatoid-arthritis
#19
REVIEW
Kayo Masuko
Recent evidence suggests that common factor(s) or molecule(s) might regulate lipid and glucose metabolism, inflammation, and bone and cartilage degeneration. These findings may be particularly relevant for cases of rheumatoid arthritis, in which chronic inflammation occurs in an autoimmune context and causes the degradation of articular joints as well as insulin resistance and cardiovascular complications. Candidates for this common regulatory system include signals mediated by peroxisome proliferator-activated regulator and its response factor, angiopoietin-like 4...
December 22, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28001327/supraspinatus-tendon-overuse-results-in-degenerative-changes-to-tendon-insertion-region-and-adjacent-humeral-cartilage-in-a-rat-model
#20
Akia N Parks, Jennifer McFaline-Figueroa, Anne Coogan, Emma Poe-Yamagata, Robert E Guldberg, Manu O Platt, Johnna S Temenoff
The etiology of rotator cuff tendon overuse injuries is still not well understood. Furthermore, how this overuse injury impacts other components of the glenohumeral joint, including nearby articular cartilage, is also unclear. Therefore, this study sought to better understand the time course of tendon protease activity in a rat model of supraspinatus overuse, as well as determine effects of 10 weeks of overuse on humeral head articular cartilage. For these studies, multiplex gelatin zymography was used to characterize protease activity profiles in tendon and cartilage, while histological scoring/mechanical testing and micro-computed tomography (μCT) imaging were used to quantify structural damage in the supraspinatus tendon insertion and humeral articular cartilage, respectively...
December 21, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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