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Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society

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https://www.readbyqxmd.com/read/28796280/effects-of-combined-teriparatide-and-zoledronic-acid-on-posterior-lumbar-vertebral-fusion-in-an-aged-ovariectomized-rat-model-of-osteopenia
#1
Mumingjiang Yishake, Miersalijiang Yasen, Libo Jiang, Wangmi Liu, Rong Xing, Qian Chen, Hong Lin, Jian Dong
There has been no study regarding the effect of a combination of teriparatide (TPTD) and zoledronic acid (ZA) on vertebral fusion. In this study, we investigate the effect of single and combined TPTD and ZA treatment on lumbar vertebral fusion in aged ovariectomized (OVX) rats. Sixty two-month-old female Sprague-Dawley rats were ovariectomized and underwent bilateral L4-5 posterolateral intertransverse fusion after ten months. The OVX rats received vehicle (control) treatment, or ZA (100µg/kg, once), or TPTD (60µg/kg/2 d for 42 d), or ZA + TPTD until they were euthanized at six weeks following lumbar vertebral fusion...
August 10, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28792101/letter-to-the-editor-re-r-k-whittaker-et-al-the-variation-in-taper-surface-roughness-for-a-single-design-effects-the-wear-rate-in-total-hip-arthroplasty
#2
LETTER
Richard B Cook
I read this article with great interest given the subject material and the fact that is supported the interesting finding from David Langton's (1) work. However, I am very concerned about the accuracy of the measurements presented. The study uses roughness measurements to characterise the taper surfaces and cites the appropriate standards for the measurement, but the authors have failed to adhere to the standards and as such the values presented as R values may be subject to measurement errors rendering them inaccurate, which could be affecting the study's findings...
August 9, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28792082/rotator-cuff-healing-using-demineralized-cancellous-bone-matrix-sponge-interposition-compared-to-standard-repair-in-a-preclinical-canine-model
#3
Matthew J Smith, Ferris M Pfeiffer, Cristi R Cook, Keiichi Kuroki, James L Cook
This Level II study assessed clinically relevant outcomes for repair of large, retracted infraspinatus tendons (ISTs) using a demineralized bone matrix (DBM) sponge (FlexiGraft) hydrated in platelet-rich plasma (PRP) versus direct repair in a validated canine model. Adult research dogs (n = 10) were used. The IST was transected in each shoulder (n = 20) and randomized to direct repair or repair with DBM-PRP interposition at 4 weeks posttransection. At 12 weeks postrepair, dogs were sacrificed, and the repair evaluated by magnetic resonance imaging (MRI), histology, and biomechanical testing...
August 9, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28786534/muscle-stem-cell-activation-in-a-mouse-model-of-rotator-cuff-injury
#4
Michael R Davies, Steven Garcia, Stanley Tamaki, Xuhui Liu, Solomon Lee, Anthony Jose, Jason H Pomerantz, Brian T Feeley
Rotator cuff (RC) tears are frequently complicated by muscle atrophy. Muscle stem cells (MuSCs) repair damaged myofibers following injury, but their role in the prevention or pathogenesis of atrophy following RC tears remains undefined. We hypothesized that the RC MuSC population would be affected by supraspinatus (SS) and infraspinatus (IS) tendon transection (TT) compared to uninjured muscle in a mouse model of RC tear. C57BL6/J mice underwent unilateral SS and IS TT and contralateral sham surgery. At 3, 8, or 14 weeks after injury, mice were euthanized and SS and IS were harvested for FACS sorting of CD31-/CD45-/Sca1-/ITGa7 + /VCAM+ MuSCs or histological analysis...
August 8, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28786500/increased-vascularization-promotes-functional-recovery-in-the-transected-spinal-cord-rats-by-implanted-vascular-endothelial-growth-factor-targeting-collagen-scaffold
#5
Lingjun Wang, Qin Shi, Jianwu Dai, Yong Gu, Yu Feng, Liang Chen
Spine cord injury (SCI) is global health concern. The effective strategies for SCI are relevant to the improvement on nerve regeneration microenvironment. Vascular endothelial growth factor (VEGF) is an important cytokine for inducing angiogenesis and accelerating nerve system function recovery from injury. We proposed that VEGF could improve nerve regeneration in SCI. However, an uncontrolled delivery system target to injury site not only decreases the therapeutic efficacy but also increases the risk of tumor information...
August 8, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28782837/in-situ-force-in-the-anterior-cruciate-ligament-the-lateral-collateral-ligament-and-the-anterolateral-capsule-complex-during-a-simulated-pivot-shift-test
#6
Kevin M Bell, Ata A Rahnemai-Azar, Sebastian Irarrazaval, Daniel Guenther, Freddie H Fu, Volker Musahl, Richard E Debski
The role of the anterolateral capsule complex in knee rotatory stability remains controversial. Therefore, the objective of this study was to determine the in-situ forces in the anterior cruciate ligament (ACL), the anterolateral capsule, the lateral collateral ligament (LCL), and the forces transmitted between each region of the anterolateral capsule in response to a simulated pivot shift test. A robotic testing system applied a simulated pivot shift test continuously from full extension to 90(o) of flexion to intact cadaveric knees (n = 7)...
August 7, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28782831/customized-degradable-functionally-graded-scaffold-for-potential-treatment-of-early-stage-osteonecrosis-of-the-femoral-head
#7
Toshiyuki Kawai, Yaser Shanjani, Saba Fazeli, Anthony W Behn, Yaichiro Okuzu, Stuart B Goodman, Yunzhi P Yang
Osteonecrosis of the femoral head (ONFH) is a debilitating disease that results in progressive collapse of the femoral head and subsequent degenerative arthritis. Few treatments provide both sufficient mechanical support and biological cues for regeneration of bone and vascularity when the femoral head is still round and therefore salvageable. We designed and 3D printed a functionally-graded scaffold (FGS) made of polycaprolactone (PCL) and β-tricalcium phosphate (β-TCP) with spatially controlled porosity, degradation and mechanical strength properties to reconstruct necrotic bone tissue in the femoral head...
August 7, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28776762/vein-wrapping-facilitates-basic-fibroblast-growth-factor-induced-heme-oxygenase-1-expression-following-chronic-nerve-constriction-injury
#8
Naoya Hirosawa, Kentaro Uchida, Kazuki Kuniyoshi, Kenichi Murakami, Gen Inoue, Masayuki Miyagi, Yusuke Matsuura, Sumihisa Orita, Kazuhide Inage, Takane Suzuki, Masashi Takaso, Seiji Ohtori
The clinical efficacy of autologous vein wrapping for recurrent compressive neuropathy has been demonstrated; however, the underlying mechanisms of this technique remain unclear. Rats were divided into chronic constriction injury (CCI) and CCI + vein wrapping (CCI + VW) groups. Mechanical allodynia was evaluated using von Frey filaments. To identify the neuroprotective factors released from veins, basic fibroblast growth factor (bFGF) mRNA expression in veins was compared to that in the sciatic nerve...
August 4, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28776751/risk-factors-can-classify-individuals-who-develop-accelerated-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#9
Jeffrey B Driban, Timothy E McAlindon, Mamta Amin, Lori Lyn Price, Charles B Eaton, Julie E Davis, Bing Lu, Grace H Lo, Jeffrey Duryea, Mary F Barbe
We assessed which combinations of risk factors can classify adults who develop accelerated knee osteoarthritis (KOA) or not and which factors are most important. We conducted a case-control study using data from baseline and the first 4 annual visits of the Osteoarthritis Initiative. Participants had no radiographic KOA at baseline (Kellgren-Lawrence [KL] < 2). We classified 3 groups (matched on sex): 1) accelerated KOA: >1 knee developed advance-stage KOA (KL = 3 or 4) within 48 months, 2) typical KOA: >1 knee increased in radiographic scoring (excluding those with accelerated KOA), and 3) No KOA: no change in KL grade by 48 months...
August 4, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28767180/improved-union-and-bone-strength-in-a-mouse-model-of-nf1-pseudarthrosis-treated-with-recombinant-human-bone-morphogenetic-protein-2-and-zoledronic-acid
#10
Nikita Deo, Tegan L Cheng, Kathy Mikulec, Lauren Peacock, David G Little, Aaron Schindeler
Tibial pseudarthrosis associated with Neurofibromatosis type 1 (NF1) is an orthopedic condition with consistently poor clinical outcomes. Using a murine model that features localized double inactivation of the Nf1 gene in an experimental tibial fracture, we tested the effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) and/or the bisphosphonate zoledronic acid (ZA). Tibiae were harvested at 3 weeks for analysis, at which time there was negligible healing in un-treated control fractures (7% union)...
August 2, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28767178/chemokine-receptor-7-ccr7-deficiency-leads-to-delayed-development-of-joint-damage-and-functional-deficits-in-a-murine-model-of-osteoarthritis
#11
Nisha Sambamurthy, Vu Nguyen, Ryan Smalley, Rui Xiao, Kurt Hankenson, Justin Gan, Rachel E Miller, Anne-Marie Malfait, George R Dodge, Carla R Scanzello
Elevated chemokine receptor Ccr7 is observed in knee osteoarthritis (OA) and associated with severity of symptoms. In this study, we confirmed that CCR7 protein expression is elevated in synovial tissue from OA patients by immunohistochemical staining. We then investigated whether Ccr7 deficiency impacted structural and functional joint degeneration utilizing a murine model of OA. OA-like disease was induced in male C57BL/6 and Ccr7-deficient (Ccr7(-/-) ) mice by destabilization of the medial meniscus (DMM)...
August 2, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28763118/mechanical-stimulation-of-mesenchymal-stem-cells-implications-for-cartilage-tissue-engineering
#12
REVIEW
Niamh Fahy, Mauro Alini, Martin J Stoddart
Articular cartilage is a load-bearing tissue playing a crucial mechanical role in diarthrodial joints, facilitating joint articulation, and minimizing wear. The significance of biomechanical stimuli in the development of cartilage and maintenance of chondrocyte phenotype in adult tissues has been well documented. Furthermore, dysregulated loading is associated with cartilage pathology highlighting the importance of mechanical cues in cartilage homeostasis. The repair of damaged articular cartilage resulting from trauma or degenerative joint disease poses a major challenge due to a low intrinsic capacity of cartilage for self-renewal, attributable to its avascular nature...
August 1, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28762588/an-investigation-of-shock-wave-therapy-and-low-intensity-pulsed-ultrasound-on-fracture-healing-under-reduced-loading-conditions-in-an-ovine-model
#13
Benjamin C Gadomski, Kirk C McGilvray, Jeremiah T Easley, Ross H Palmer, Jian Jiao, Xiaofei Li, Yi-Xian Qin, Christian M Puttlitz
The use of shock wave therapy (SWT) and low-intensity pulsed ultrasound (LIPUS) as countermeasures to the inhibited fracture healing experienced during mechanical unloading was investigated by administering treatment to the fracture sites of mature, female, Rambouillet Columbian ewes exposed to partial mechanical unloading or full gravitational loading. The amount of fracture healing experienced by the treatment groups was compared to controls in which identical surgical and testing protocols were administered except for SWT or LIPUS treatment...
August 1, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28762567/rotator-cuff-repair-with-a-novel-mesh-suture-an-ex-vivo-assessment-of-mechanical-properties
#14
Tao Zhang, Taku Hatta, Andrew R Thoreson, ChengChang Lu, Scott P Steinmann, Steven L Moran, Chunfeng Zhao
Surgical repair is a common treatment for rotator cuff tear; however, the retear rate is high. A high degree of suture repair strength is important to ensure rotator cuff integrity for healing. The purpose of this study was to compare the mechanical performance of rotator cuffs repaired with a mesh suture vs traditional polydioxanone suture II and FiberWire sutures in a canine in vitro model. Seventy-two canine shoulders were harvested. An infraspinatus tendon tear was created in each shoulder. Two suture techniques-simple interrupted sutures and 2-row suture bridge-were used to reconnect the infraspinatus tendon to the greater tuberosity, using 3 different suture types: mesh suture, polydioxanone suture II, or FiberWire...
August 1, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28762563/femoral-fracture-type-can-be-predicted-from-femoral-structure-a-finite-element-study-validated-by-digital-volume-correlation-experiments
#15
M Ikhwan Z Ridzwan, Chamaiporn Sukjamsri, Bidyut Pal, Richard J van Arkel, Andrew Bell, Monica Khanna, Aroon Baskaradas, Richard Abel, Oliver Boughton, Justin Cobb, Ulrich N Hansen
Proximal femoral fractures can be categorised into two main types: neck and intertrochanteric fractures accounting for 53% and 43% of all proximal femoral fractures, respectively. The possibility to predict the type of fracture a specific patient is predisposed to would allow drug and exercise therapies, hip protector design and prophylactic surgery to be better targeted for this patient rendering fracture preventing strategies more effective. This study hypothesized that the type of fracture is closely related to the patient-specific femoral structure and predictable by finite element (FE) methods...
August 1, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28762536/a-novel-mr-based-method-for-detection-of-cartilage-delamination-in-femoroacetabular-impingement-patients
#16
Michael A Samaan, Valentina Pedoia, Alan L Zhang, Matthew C Gallo, Thomas M Link, Richard B Souza, Sharmila Majumdar
In this study, quantitative magnetic resonance based measurements were used to evaluate T1ρ and T2 mapping and heterogeneity in femoroacetabular impingement (FAI) patients with acetabular cartilage delamination and to determine the ability of these quantitative MR-based measurements in detecting delamination. Unilateral hip joint MR-scans of 36 FAI patients with arthroscopically-confirmed acetabular cartilage delamination and 36 age, gender and BMI matched controls were obtained. T1ρ and T2 mapping and heterogeneity of the hip joint articular cartilage were assessed in both groups using voxel-based relaxometry (VBR)...
August 1, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28755495/identification-of-good-candidates-for-valgus-bracing-as-a-treatment-for-medial-knee-osteoarthritis
#17
Allison L Clouthier, Elizabeth A Hassan, Scott Ce Brandon, Aaron Campbell, Michael J Rainbow, Kevin J Deluzio
Valgus unloader braces are a conservative treatment option for medial compartment knee osteoarthritis that aim to unload the damaged medial compartment through application of an external abduction moment. Patient response to bracing is highly variable, however. While some experience improvements in pain, function, and joint loading, others receive little to no benefit. The objective of this work was to analyze clinical measures and biomechanical characteristics of unbraced walking to identify variables that are associated with the mechanical effectiveness of valgus unloader bracing...
July 29, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28755488/bilateral-quadriceps-and-hamstrings-muscle-volume-asymmetries-in-healthy-individuals
#18
Anthony S Kulas, Randy J Schmitz, Sandra J Shultz, Justin P Waxman, Hsin-Min Wang, Robert A Kraft, Heath S Partington
Determining the magnitude of quadriceps and hamstring muscle volume asymmetries in healthy individuals is a critical first step toward interpreting asymmetries as compensatory or abnormal in pathological populations. The purpose of this study was to determine the magnitude of whole and individual muscle volume asymmetries, quantified as right-left volume differences, for the quadriceps and hamstring muscles in a young and healthy population. Twenty-one healthy individuals participated: Eleven females age = 22...
July 29, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28755471/mechanical-loading-disrupts-osteocyte-plasma-membranes-which-initiates-mechanosensation-events-in-bone
#19
Kanglun Yu, David P Sellman, Anoosh Bahraini, Mackenzie L Hagan, Ahmed Elsherbini, Kayce T Vanpelt, Peyton L Marshall, Mark W Hamrick, Anna McNeil, Paul L McNeil, Meghan E McGee-Lawrence
Osteocytes sense loading in bone, but their mechanosensation mechanisms remain poorly understood. Plasma membrane disruptions (PMD) develop with loading under physiological conditions in many cell types (e.g., myocytes, endothelial cells). These PMD foster molecular flux across cell membranes that promotes tissue adaptation, but this mechanosensation mechanism had not been explored in osteocytes. Our goal was to investigate whether PMD occur and initiate consequent mechanotransduction in osteocytes during physiological loading...
July 29, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28755470/the-role-of-mechanobiology-in-progression-of-rotator-cuff-muscle-atrophy-and-degeneration
#20
Michael C Gibbons, Anshuman Singh, Adam J Engler, Samuel R Ward
Rotator cuff (RC) muscles undergo several detrimental changes following mechanical unloading resulting from RC tendon tear. In this review, we highlight the pathological causes and consequences of mechanical alterations at the whole muscle, muscle fiber, and muscle resident cell level as they relate to RC disease progression. In brief, the altered mechanical loads associated with RC tear lead to architectural, structural, and compositional changes at the whole-muscle and muscle fiber level. At the cellular level, these changes equate to direct disruption of mechanobiological signaling, which is exacerbated by mechanically regulated biophysical and biochemical changes to the cellular and extra-cellular environment (also known as the stem cell "niche")...
July 29, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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