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Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society

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https://www.readbyqxmd.com/read/30387528/stiff-knee-gait-may-increase-risk-of-second-total-knee-arthroplasty
#1
Joseph A Zeni, Portia Flowers, Michael Bade, Victor Cheuy, Jennifer Stevens-Lapsley, Lynn Snyder-Mackler
Osteoarthritis (OA) progression in the contralateral limb after unilateral total knee arthroplasty (TKA) may be related to altered and asymmetrical movement patterns that overload the contralateral joints. The purpose of this study was to determine if biomechanical factors after unilateral TKA were associated with future contralateral TKA. 158 individuals who underwent unilateral TKA completed three dimensional motion analysis 6-24 months after unilateral TKA (baseline). Subjects were re-contacted for follow-up (mean 5...
November 2, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30378184/good-correlation-between-bone-tracer-uptake-in-spect-ct-and-intraoperative-findings-of-chondral-lesions-graded-with-the-icrs-scoring
#2
Nora Ammann, Filippo-Franco Schiapparelli, Lukas B Moser, Helmut Rasch, Felix Amsler, Michael T Hirschmann
The question if bone tracer uptake in SPECT/CT reflects the intraoperative cartilage status of the knee is still unanswered. In this study, thirty-three consecutive patients (male:female = 11:22; mean age ± standard deviation 61 ± 15) with bi- or tri-compartmental knee osteoarthritis who underwent SPECT/CT before total knee arthroplasty (TKA) were collected. The knee was graded in eleven different anatomical regions. In each region, the maximal relative bone tracer uptake (mrBTU) was measured twice by two observers with a six weeks interval...
October 31, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30378182/tenocyte-cell-density-migration-and-extracellular-matrix-deposition-with-amniotic-suspension-allograft
#3
Kelly A Kimmerling, John P McQuilling, Miranda C Staples, Katie C Mowry
Amniotic suspension allografts (ASA), derived from placental tissues, contain particulated amniotic membrane and amniotic fluid cells. Recently, ASA and other placental-derived allografts have been used in orthopaedic applications, including tendinopathies and tendon injuries. The purpose of this study was to determine the potential effects of ASA on tenocyte cell density, migration, and responses to inflammatory stimuli. Tenocyte cell density was measured using AlamarBlue over multiple time points, while migration was determined using a Boyden chamber assay...
October 31, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30378173/intra-articular-autologous-uncultured-adipose-derived-stromal-cell-transplantation-inhibited-the-progression-of-cartilage-degeneration
#4
Yuichi Kuroda, Tomoyuki Matsumoto, Shinya Hayashi, Shingo Hashimoto, Koji Takayama, Shinsuke Kirizuki, Masanori Tsubosaka, Tomoyuki Kamenaga, Yoshinori Takashima, Takehiko Matsushita, Takahiro Nikura, Ryosuke Kuroda
The role of uncultured adipose-derived stromal cells for osteoarthritis treatment remains unclear despite sporadic reports supporting their use in clinical settings. This study aimed to evaluate the therapeutic effects of autologous uncultured adipose-derived stromal cell transplantation in a rabbit osteoarthritis model. Uncultured adipose-derived stromal cells isolated from rabbits were administered via intra-articular injection into the knees after osteoarthritis onset. Animals were sacrificed at 8 and 12 weeks after osteoarthritis onset to compare the macroscopic, histological, and immunohistochemical characteristics between the uncultured adipose-derived stromal cell and control groups...
October 31, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30378172/low-frequency-pulsed-electromagnetic-field-promotes-the-recovery-of-neurological-function-after-spinal-cord-injury-in-rats
#5
Ziyu Li, Fei Yao, Li Cheng, Wendan Cheng, Lei Qi, Shuisheng Yu, Liqian Zhang, Xiaowei Zha, Juehua Jing
Low frequency pulsed electromagnetic field (LFPEMF) has been shown to provide anti-inflammatory and antioxidative effects. However, there are no reports on whether LFPEMF can treat spinal cord injury (SCI) and its therapeutic mechanism. Therefore, this study was conducted to investigate whether LFPEMF can promote the recovery of neurological function after SCI in rats and its therapeutic mechanism. Basso-Beattie-Bresnahan (BBB) score and transcranial magnetic motor-evoked potentials (tcMMEPs) were recorded to assess the recovery of neurological function...
October 31, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30370678/nano-and-micro-biomechanical-alterations-of-annulus-fibrosus-after-in-situ-immobilization-revealed-by-atomic-force-microscopy
#6
Ting Liang, Yan-Jun Che, Xi Chen, Hai-Tao Li, Hui-Lin Yang, Zong-Ping Luo
Annulus fibrosus is critical to bear loads and resist fluid flow in the intervertebral disc. However, the detailed biomechanical mechanism of annulus fibrosus under abnormal loading is still ambiguous, especially at the micro and nano scales. This study aims to characterize the alterations of modulus at the nano scale of individual collagen fibrils in annulus fibrosus after in-situ immobilization, and the corresponding micro-biomechanics of annulus fibrosus. An immobilization model was used on the rat tail with an external fixation device...
October 29, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30370584/fibronectin-induced-itg%C3%AE-1-fak-dependent-apoptotic-pathways-determines-the-fate-of-degenerative-np-cells
#7
Xinghuo Wu, Kun Wang, Wenbin Hua, Shuai Li, Xianzhe Liu, Yu Song, Yukun Zhang, Zengwu Shao, Suyun Li, Cao Yang
Intervertebral disc (IVD) degeneration is caused by a decrease in nucleus pulposus (NP) cells, due mainly to apoptosis. Focal adhesion kinase (FAK) is involved in the integrin (ITG)-mediated control of cell adhesion and anoikis (apoptosis). To explore the involvement of ITGβ1/FAK-dependent apoptotic pathways in disc degeneration, histological and molecular biological studies on the protein expression of fibronectin (FN), ITGβ1, and syndecan 4 (SYND4) in non-degenerative and degenerative NP tissues were conducted...
October 29, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30370699/the-cellular-biology-of-fracture-healing
#8
Chelsea S Bahney, Robert L Zondervan, Patrick Allison, Alekos Theologis, Jason Ashley, Jaimo Ahn, Theodore Miclau, Ralph Marcucio, Kurt D Hankenson
The biology of bone healing is a rapidly developing science. Advances in transgenic and gene-targeted mice have enabled tissue and cell-specific investigations of skeletal regeneration. As an example, only recently has it been recognized that chondrocytes convert to osteoblasts during healing bone, and only several years prior, seminal publications reported definitively that the primary tissues contributing bone forming cells during regeneration were the periosteum and endosteum. While genetically modified animals offer incredible insights into the temporal and spatial importance of various gene products, the complexity and rapidity of healing-coupled with the heterogeneity of animal models-renders studies of regenerative biology challenging...
October 28, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30345583/nicotine-impairs-intra-substance-tendon-healing-after-full-thickness-injury-in-a-rat-model
#9
Adnan N Cheema, Joseph B Newton, James F Boorman-Padgett, Stephanie N Weiss, Courtney A Nuss, Daniel J Gittings, Daniel C Farber, Louis J Soslowsky
Nicotine is harmful to many bodily systems; however, the effects of nicotine on intra-substance tendon healing remain largely unexplored. The purpose of this study was to examine the functional, structural, and biomechanical effects of nicotine on the healing of Achilles tendons in rats after an acute full-thickness injury. Sixty Sprague-Dawley rats were enrolled in this study. Half were exposed to 0.9% saline and half to 61ng/mL of nicotine for 3 months via subcutaneous osmotic pumps. At 3 months, all rats underwent blunt full thickness transection of the left Achilles tendon and were immobilized for one week in plantarflexion...
October 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30345568/a-method-for-quantitative-assessment-of-acetabular-bone-defects
#10
Georg Hettich, Ronja A Schierjott, Heiko Ramm, Heiko Graichen, Volkmar Jansson, Maximilian Rudert, Francesco Traina, Thomas M Grupp
The objective of the study was to suggest a novel quantitative assessment of acetabular bone defects based on a statistical shape model, validate the method, and present preliminary results. Two exemplary CT-data sets with acetabular bone defects were segmented to obtain a solid model of each defect pelvis. The pathological areas around the acetabulum were excluded and a statistical shape model was fitted to the remaining healthy bone structures. The excluded areas were extrapolated such that a solid model of the native pelvis per specimen resulted (i...
October 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30345548/study-on-the-three-dimensional-orientation-of-the-posterior-facet-of-the-subtalar-joint-using-simulated-weight-bearing-ct
#11
Roeland P Kleipool, Jari Dahmen, Gwen Vuurberg, Roelof-Jan Oostra, Leendert Blankevoort, Markus Knupp, Sjoerd A S Stufkens
The purpose of this study was to describe the normal 3D orientation and shape of the subtalar calcaneal posterior facet. This is not adequately described in current literature. In a supine position both feet of 20 healthy subjects were imaged in a simulated weight-bearing CT. A cylinder and plane were fitted to the posterior facet of the surface model. The orientation of both shapes was expressed by two angles in (1) the CT-based coordinate system with the axis of the foot aligned with the sagittal axis and (2) a coordinate system based on the geometric principal axes of the subject's calcaneus...
October 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30345546/radiographic-cortical-thickness-parameters-as-predictors-of-rotational-alignment-in-proximal-femur-fractures-a-cadaveric-study
#12
Christian Zeckey, Miriam Bogusch, Martin Borkovec, Christopher A Becker, Carl Neuerburg, Simon Weidert, Eduardo M Suero, Wolfgang Böcker, Axel Greiner, Christian Kammerlander
Radiographic assessment tools such as the cortical step sign (CSS) or the diameter difference sign (DDS) aim to identify clinically relevant rotational malalignment after long bone fracture fixation. We aimed to analyze the effect of rotational malalignment on CSS and DDS parameters in a subtrochanteric fracture model and to construct a prognostic model to identify clinically relevant rotational malalignment. A subtrochanteric transverse osteotomy was set in human femora. Rotation was set stepwise from 0° to 30° in internal and external rotation...
October 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30345545/vegf-with-amd3100-endogenously-mobilizes-mesenchymal-stem-cells-and-improves-fracture-healing
#13
Richard Meeson, Anita Sanghani-Keri, Melanie Coathup, Gordon Blunn
A significant number of fractures develop non-union. Mesenchymal stem cell (MSC) therapy may be beneficial, however this requires cell acquisition, culture and delivery. Endogenous mobilization of stem cells offers a non-invasive alternative. The hypothesis was administration of VEGF and the CXCR4 antagonist AMD3100 would increase the circulating pool of available MSCs and improve fracture healing. Ex-breeder female wistar rats received VEGF followed by AMD3100, or sham PBS. Blood prepared for culture and colonies were counted...
October 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30341934/ability-of-a-wash-regimen-to-remove-biofilm-from-the-exposed-surface-of-materials-used-in-osseointegrated-implants
#14
Gina Allyn, Roy D Bloebaum, Richard T Epperson, Mattias B Nielsen, Kevin A Dodd, Dustin L Williams
The skin/implant interface of osseointegrated (OI) implants is susceptible to infection, causing excess pain, increased morbidity, and possibly implant removal. Novel distal femoral OI implants with binary nitride coatings have been developed with little physiological modeling to collect microbiological evidence of resistance to bacterial attachment. This in vitro study evaluated a Ti-6Al-4V alloy coated with TiNbN and treated with low plasticity burnishing (LPB) to assess attachment and biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA) under physiologically-modeling conditions compared to standard Ti-6Al-4V alloy materials with a polished ("Color Buff") or non-polished finish ("Satin Finish")...
October 20, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30325073/vancomycin-elution-kinetics-from-porous-tantalum-metal
#15
Pierre Sautet, Thibaut Mékidèche, Romain Guilhaumou, Matthew P Abdel, Jean-Noël Argenson, Sébastien Parratte, Matthieu Ollivier
Revisions TKAs are being completed with uncemented constructs more frequently. We hypothesized that tantalum cones could be an efficient carrier of antibiotics in uncemented procedures. We aimed to compare the release of vancomycin between 1) tantalum and smooth stainless cylinders, 2) different concentrations of vancomycin and 3) different durations of bathing. Specifically designed tantalum cylinders were bathed in a vancomycin solution with various durations of baths. We investigated rinses between each interval as well as the dose of vancomycin...
October 16, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30325066/duration-of-symptoms-is-associated-with-conditioned-pain-modulation-and-somatosensory-measures-in-knee-osteoarthritis
#16
Kharma C Foucher, Samuel J Chmell, Carol A Courtney
Impaired descending pain inhibition has been linked to chronic pain and poorer patient outcomes. Vibration perception threshold (VPT) has also been observed and linked to radiographic stage of OA. However, it is not known how duration of symptoms may influence these neurophysiological measures. Our purpose was to evaluate the relationship between duration of symptoms and conditioned pain modulation (CPM), a measure of descending pain inhibition, and VPT, and to determine whether these relationships differed in men and women seeking orthopedic care...
October 16, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30325061/the-influence-of-rotator-cuff-tears-on-muscle-and-joint-contact-loading-after-reverse-total-shoulder-arthroplasty
#17
David C Ackland, Dale L Robinson, Adam Wilkosz, Wen Wu, Martin Richardson, Peter Lee, Kwong Ming Tse
Rotator cuff tears are known to affect clinical outcome of reverse total shoulder arthroplasty (RSA). This study aimed to use computational modelling to quantify the effect of rotator cuff tear severity on muscle and joint forces after RSA, as well as stresses at the glenosphere, base-plate, fixation screws, scapula, and humeral components. A multi-body musculoskeletal model of the glenohumeral joint was developed comprising the scapula, humerus and nine major upper limb muscles. Simulations of abduction and flexion after RSA were performed in the case of the intact rotator cuff and tears to (i) supraspinatus; (ii) supraspinatus and infraspinatus, and (iii) supraspinatus, infraspinatus and subscapularis...
October 16, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30307059/targeted-proteomics-of-hip-articular-cartilage-in-oa-and-fracture-patients
#18
Shahrzad Hosseininia, Patrik Önnerfjord, Leif E Dahlberg
Osteoarthritis (OA) is a common chronic disease, causing joint pain and reduced physical function. OA progresses slowly over a period of several years; to avoid an exacerbation of symptoms, it is critical to able to diagnose the disease as early as possible. The identification of disease-specific biomarkers may enable such an early diagnosis. The aim of this study was to investigate potential biomarkers of cartilage metabolism in OA using a targeted multiplex approach by single reaction monitoring. Intact looking cartilage of femoral heads from patients with OA (n = 9) or femoral neck fractures (n = 12) was examined...
October 11, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30303555/gait-biomechanics-after-combined-hto-acl-reconstruction-versus-hto-alone-a-matched-cohort-study
#19
Kendal Marriott, Trevor B Birmingham, Ryan Pinto, Codie Primeau, Dianne Bryant, Ryan Degen, J Robert Giffin
The purpose of the present study was to compare bilateral external knee moments during gait in patients with concomitant medial compartment knee OA, varus alignment and chronic anterior cruciate ligament (ACL) deficiency who underwent either medial opening-wedge high tibial osteotomy alone (HTO) or simultaneous HTO and ACL reconstruction (HTO-ACLR). Fifty-two patients (26 matched pairs) completed 3D gait analysis preoperatively and at a minimum 5 years postoperatively. Patients were matched for preoperative age, sex, body mass index and magnitude of correction...
October 10, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/30298950/mr-study-of-longitudinal-variations-in-proximal-femur-3d-morphological-shape-and-associations-with-cartilage-health-in-hip-osteoarthritis
#20
Gaurav Inamdar, Valentina Pedoia, Jasmine Rossi-Devries, Michael A Samaan, Thomas M Link, Richard B Souza, Sharmila Majumdar
The goal of this study was to use quantitative MRI analysis to longitudinally observe the relationship between 3D proximal femur shape and hip joint degenerative changes. Forty-six subjects underwent unilateral hip MR imaging at three time points (baseline, 18 and 36 months). 3D shape analysis, hip cartilage T1ρ /T2 relaxation time quantification, and SHOMRI MRI grading were performed at each time point. Subjects were grouped based on KL, SHOMRI, and HOOS pain scores. Associations between these score groupings, time, and longitudinal variation in shape, were analyzed using a generalized estimating equation...
October 9, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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