journal
MENU ▼
Read by QxMD icon Read
search

Biotechnology Advances

journal
https://www.readbyqxmd.com/read/28928003/learning-from-quantitative-data-to-understand-central-carbon-metabolism
#1
REVIEW
Fumio Matsuda, Yoshihiro Toya, Hiroshi Shimizu
Quantitative analysis of metabolism has been used to identify driver reactions occurring during cancer development and bottleneck reactions in the metabolic engineering of microorganisms. In this review, we compare the advantages and disadvantages of various metabolic analysis methods. We emphasize that metabolic flux analysis based on material balance is a critical method for quantitative investigations into cell metabolism. The absolute determination of metabolite concentration appears to be essential for evaluating the thermodynamic state of metabolism...
September 16, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28916392/formulation-construction-and-analysis-of-kinetic-models-of-metabolism-a-review-of-modelling-frameworks
#2
REVIEW
Pedro A Saa, Lars K Nielsen
Kinetic models are critical to predict the dynamic behaviour of metabolic networks. Mechanistic kinetic models for large networks remain uncommon due to the difficulty of fitting their parameters. Recent modelling frameworks promise new ways to overcome this obstacle while retaining predictive capabilities. In this review, we present an overview of the relevant mathematical frameworks for kinetic formulation, construction and analysis. Starting with kinetic formalisms, we next review statistical methods for parameter inference, as well as recent computational frameworks applied to the construction and analysis of kinetic models...
September 12, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28916391/zika-virus-structural-biology-and-progress-in-vaccine-development
#3
REVIEW
Hsiao-Han Lin, Bak-Sau Yip, Li-Min Huang, Suh-Chin Wu
The growing number of zika virus (ZIKV) infections plus a 20-fold increase in neonatal microcephaly in newborns in Brazil have raised alarms in many countries regarding the threat to pregnant women. Instances of microcephaly and central nervous system malformations continue to increase in ZIKV outbreak regions. ZIKV is a small enveloped positive-strand RNA virus belonging to the Flavivirus genus of the Flaviviridae family. High-resolution ZIKV structures recently identified by cryo-electron microscopy indicate that the overall ZIKV structure is similar to those of other flaviviruses...
September 12, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28911809/taxonomy-ecology-and-biotechnological-applications-of-thraustochytrids-a-review
#4
REVIEW
Loris Fossier Marchan, Kim J Lee Chang, Peter D Nichols, Wilfrid J Mitchell, Jane L Polglase, Tony Gutierrez
Thraustochytrids were first discovered in 1934, and since the 1960's they have been increasingly studied for their beneficial and deleterious effects. This review aims to provide an enhanced understanding of these protists with a particular emphasis on their taxonomy, ecology and biotechnology applications. Over the years, thraustochytrid taxonomy has improved with the development of modern molecular techniques and new biochemical markers, resulting in the isolation and description of new strains. In the present work, the taxonomic history of thraustochytrids is reviewed, while providing an up-to-date classification of these organisms...
September 11, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28888552/chassis-and-key-enzymes-engineering-for-monoterpenes-production
#5
REVIEW
Lu Zhang, Wen-Hai Xiao, Ying Wang, Ming-Dong Yao, Guo-Zhen Jiang, Bo-Xuan Zeng, Ruo-Si Zhang, Ying-Jin Yuan
Microbial production of monoterpenes is often limited by their cytotoxicity and in vivo conversion. Therefore, alleviating cytotoxicity and reducing conversion by chassis engineering are highly desirable. On the other hand, engineering key enzymes is also critical for improving monoterpenes production through facilitating the biosynthesis process. Here we critically review recent advances in cytotoxicity alleviation, reducing in vivo conversion, selecting geranyl diphosphate synthase and engineering monoterpene synthases...
September 6, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28888551/amino-acids-production-focusing-on-fermentation-technologies-a-review
#6
REVIEW
Martina D'Este, Merlin Alvarado-Morales, Irini Angelidaki
Amino acids are attractive and promising biochemicals with market capacity requirements constantly increasing. Their applicability ranges from animal feed additives, flavour enhancers and ingredients in cosmetic to specialty nutrients in pharmaceutical and medical fields. This review gives an overview of the processes applied for amino acids production and points out the main advantages and disadvantages of each. Due to the advances made in the genetic engineering techniques, the biotechnological processes, and in particular the fermentation with the aid of strains such as Corynebacterium glutamicum or Escherichia coli, play a significant role in the industrial production of amino acids...
September 6, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28870855/growth-media-in-anaerobic-fermentative-processes-the-underestimated-potential-of-thermophilic-fermentation-and-anaerobic-digestion
#7
REVIEW
A T W M Hendriks, J B van Lier, M K de Kreuk
Fermentation and anaerobic digestion of organic waste and wastewater is broadly studied and applied. Despite widely available results and data for these processes, comparison of the generated results in literature is difficult. Not only due to the used variety of process conditions, but also because of the many different growth media that are used. Composition of growth media can influence biogas production (rates) and lead to process instability during anaerobic digestion. To be able to compare results of the different studies reported, and to ensure nutrient limitation is not influencing observations ascribed to process dynamics and/or reaction kinetics, a standard protocol for creating a defined growth medium for anaerobic digestion and mixed culture fermentation is proposed...
September 1, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28844973/in-vitro-in-vivo-correlation-ivivc-in-nanomedicine-is-protein-corona-the-missing-link
#8
REVIEW
Priyanka Jain, R S Pawar, R S Pandey, Jitender Madan, Sulakshna Pawar, P K Lakshmi, M S Sudheesh
One of the unmet challenges in nanotechnology is to understand and establish the relationship between physicochemical properties of nanoparticles (NPs) and its biological interactions (bio-nano interactions). However, we are still far from assessing the biofate of NPs in a clear and unquestionable manner. Recent developments in the area of bio-nano interface and the understanding of protein corona (PC) has brought new insight in predicting biological interactions of NPs. PC refers to the spontaneous formation of an adsorbed layer of biomolecules on the surface of NPs in a biological environment...
August 26, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28830772/covalent-and-non-covalent-chemical-engineering-of-actin-for-biotechnological-applications
#9
REVIEW
Saroj Kumar, Alf Mansson
The cytoskeletal filaments are self-assembled protein polymers with 8-25nm diameters and up to several tens of micrometres length. They have a range of pivotal roles in eukaryotic cells, including transportation of intracellular cargoes (primarily microtubules with dynein and kinesin motors) and cell motility (primarily actin and myosin) where muscle contraction is one example. For two decades, the cytoskeletal filaments and their associated motor systems have been explored for nanotechnological applications including miniaturized sensor systems and lab-on-a-chip devices...
August 19, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28789939/bioremediation-3-0-engineering-pollutant-removing-bacteria-in-the-times-of-systemic-biology
#10
REVIEW
Pavel Dvořák, Pablo I Nikel, Jiří Damborský, Víctor de Lorenzo
Elimination or mitigation of the toxic effects of chemical waste released to the environment by industrial and urban activities relies largely on the catalytic activities of microorganisms-specifically bacteria. Given their capacity to evolve rapidly, they have the biochemical power to tackle a large number of molecules mobilized from their geological repositories through human action (e.g., hydrocarbons, heavy metals) or generated through chemical synthesis (e.g., xenobiotic compounds). Whereas naturally occurring microbes already have considerable ability to remove many environmental pollutants with no external intervention, the onset of genetic engineering in the 1980s allowed the possibility of rational design of bacteria to catabolize specific compounds, which could eventually be released into the environment as bioremediation agents...
August 5, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28782585/weaving-for-heart-valve-tissue-engineering
#11
REVIEW
Albert Liberski, Nadia Ayad, Dorota Wojciechowska, Radoslaw Kot, Duy M P Vo, Dilibaier Aibibu, Gerald Hoffmann, Chokri Cherif, Katharina Grobelny-Mayer, Marek Snycerski, Helmut Goldmann
Weaving is a resourceful technology which offers a large selection of solutions that are readily adaptable for tissue engineering (TE) of artificial heart valves (HV). The different ways that the yarns are interlaced in this technique could be used to produce complex architectures, such as the three-layer architecture of the leaflets. Once the assembly is complete, growth of cells in the scaffold would occur in the orientation of the yarn, enabling the deposition of extra cellular matrixes proteins in an oriented manner...
August 4, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28768145/stay-connected-electrical-conductivity-of-microbial-aggregates
#12
REVIEW
Cheng Li, Keaton Larson Lesnik, Hong Liu
The discovery of direct extracellular electron transfer offers an alternative to the traditional understanding of diffusional electron exchange via small molecules. The establishment of electronic connections between electron donors and acceptors in microbial communities is critical to electron transfer via electrical currents. These connections are facilitated through conductivity associated with various microbial aggregates. However, examination of conductivity in microbial samples is still in its relative infancy and conceptual models in terms of conductive mechanisms are still being developed and debated...
July 30, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28760369/towards-systems-metabolic-engineering-in-pichia-pastoris
#13
REVIEW
Jan-Philipp Schwarzhans, Tobias Luttermann, Martina Geier, Jörn Kalinowski, Karl Friehs
The methylotrophic yeast Pichia pastoris is firmly established as a host for the production of recombinant proteins, frequently outperforming other heterologous hosts. Already, a sizeable amount of systems biology knowledge has been acquired for this non-conventional yeast. By applying various omics-technologies, productivity features have been thoroughly analyzed and optimized via genetic engineering. However, challenging clonal variability, limited vector repertoire and insufficient genome annotation have hampered further developments...
July 29, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28739506/glycosaminoglycans-from-marine-sources-as-therapeutic-agents
#14
REVIEW
Jesus Valcarcel, Ramon Novoa-Carballal, Ricardo I Pérez-Martín, Rui L Reis, José Antonio Vázquez
Glycosaminoglycans (GAGs) in marine animals are different to those of terrestrial organisms, mainly in terms of molecular weight and sulfation. The therapeutic properties of GAGs are related to their ability to interact with proteins, which is very much influenced by sulfation position and patterns. Since currently GAGs cannot be chemically synthesized, they are sourced from natural products, with high intra- but also inter-species variability, in terms of chain length, disaccharide composition and sulfation pattern...
July 21, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28739505/valorisation-of-softwood-bark-through-extraction-of-utilizable-chemicals-a-review
#15
REVIEW
M Jablonsky, J Nosalova, A Sladkova, A Haz, F Kreps, J Valka, S Miertus, V Frecer, M Ondrejovic, J Sima, I Surina
Softwood bark is an important source for producing chemicals and materials as well as bioenergy. Extraction is regarded as a key technology for obtaining chemicals in general, and valorizing bark as a source of such chemicals in particular. In this paper, properties of 237 compounds identified in various studies dealing with extraction of softwood bark were described. Finally, some challenges and perspectives on the production of chemicals from bark are discussed.
July 21, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28729211/insight-into-immunocytes-infiltrations-in-polymorphous-light-eruption
#16
REVIEW
Dongyun Lei, Wenjuan Wu, Li Yang, Yan Li, Jiaqi Feng, Lechun Lyu, Li He
Polymorphous light eruption (PLE) which is one of the most common photodermatoses has been demonstrated to be immune-mediated disorder. Resistance to UV-induced immunosuppression resulting from differential immune cells infiltration and cytokines secretion has been highlighted in the pathogenesis of PLE. In this study, we reviewed differential patterns of immune cells infiltrations and cytokines secretion that may contribute to PLE occurrence and development.
July 17, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28723577/enabling-tools-for-high-throughput-detection-of-metabolites-metabolic-engineering-and-directed-evolution-applications
#17
REVIEW
Jyun-Liang Lin, James M Wagner, Hal S Alper
Within the Design-Build-Test Cycle for strain engineering, rapid product detection and selection strategies remain challenging and limit overall throughput. Here we summarize a wide variety of modalities that transduce chemical concentrations into easily measured absorbance, luminescence, and fluorescence signals. Specifically, we cover protein-based biosensors (including transcription factors), nucleic acid-based biosensors, coupled enzyme reactions, bioorthogonal chemistry, and fluorescent and chromogenic dyes and substrates as modalities for detection...
July 16, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28709875/bioelectrohydrogenesis-and-inhibition-of-methanogenic-activity-in-microbial-electrolysis-cells-a-review
#18
REVIEW
Rengasamy Karthikeyan, Ka Yu Cheng, Ammaiyappan Selvam, Arpita Bose, Jonathan W C Wong
Microbial electrolysis cells (MECs) are a promising technology for biological hydrogen production. Compared to abiotic water electrolysis, a much lower electrical voltage (~0.2V) is required for hydrogen production in MECs. It is also an attractive waste treatment technology as a variety of biodegradable substances can be used as the process feedstock. Underpinning this technology is a recently discovered bioelectrochemical pathway known as "bioelectrohydrogenesis". However, little is known about the mechanism of this pathway, and numerous hurdles are yet to be addressed to maximize hydrogen yield and purity...
July 12, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28694179/microalgal-bacterial-aggregates-applications-and-perspectives-for-wastewater-treatment
#19
REVIEW
Guillermo Quijano, Juan S Arcila, Germán Buitrón
Research on wastewater treatment by means of microalgal-bacterial processes has become a hot topic worldwide during the last two decades. Owing to the lower energy demand for oxygenation, the enhanced nutrient removal and the potential for resource recovery, microalgal-based technologies are nowadays considered as a good alternative to conventional activated sludge treatments in many instances. Nevertheless, biomass harvesting still constitutes one of the major challenges of microalgal-bacterial systems for wastewater treatment, which is hindered by the poor settleability of microalgal biomass...
July 8, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28694178/medicinal-plants-used-in-the-treatment-of-tuberculosis-ethnobotanical-and-ethnopharmacological-approaches
#20
REVIEW
Javad Sharifi-Rad, Bahare Salehi, Zorica Z Stojanović-Radić, Patrick Valere Tsouh Fokou, Marzieh Sharifi-Rad, Gail B Mahady, Majid Sharifi-Rad, Mohammad-Reza Masjedi, Temitope O Lawal, Seyed Abdulmajid Ayatollahi, Javid Masjedi, Razieh Sharifi-Rad, William N Setzer, Mehdi Sharifi-Rad, Farzad Kobarfard, Atta-Ur Rahman, Muhammad Iqbal Choudhary, Athar Ata, Marcello Iriti
Tuberculosis is a highly infectious disease declared a global health emergency by the World Health Organization, with approximately one third of the world's population being latently infected with Mycobacterium tuberculosis. Tuberculosis treatment consists in an intensive phase and a continuation phase. Unfortunately, the appearance of multi drug-resistant tuberculosis, mainly due to low adherence to prescribed therapies or inefficient healthcare structures, requires at least 20months of treatment with second-line, more toxic and less efficient drugs, i...
July 8, 2017: Biotechnology Advances
journal
journal
28742
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"