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Pharmacopsychiatry

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https://www.readbyqxmd.com/read/29346806/lithium-and-renal-impairment-a-review-on-a-still-hot-topic
#1
René Ernst Nielsen, Lars Vedel Kessing, Willem A Nolen, Rasmus W Licht
INTRODUCTION: Lithium is established as an effective treatment of mania, of depression in bipolar and unipolar disorder, and in maintenance treatment of these disorders. However, due to the necessity of monitoring and concerns about irreversible adverse effects, in particular renal impairment, after long-term use, lithium might be underutilized. METHODS: This study reviewed 6 large observational studies addressing the risk of impaired renal function associated with lithium treatment and methodological issues impacting interpretation of results...
January 18, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29334687/cognitive-deficits-in-methamphetamine-users-how-strong-is-the-evidence
#2
Lisa Proebstl, Felicia Kamp, Gabi Koller, Michael Soyka
Methamphetamine use has spread in many European countries and the United States. The current review provides a summary and critical analysis of research on cognitive deficits associated with methamphetamine, also known as "crystal meth." The literature search performed for this review led us to the hypothesis that methamphetamine use is associated with persistent changes in brain metabolism that result in various impairments, such as deficits in memory, attention, and concentration. The dopaminergic system in particular seems to be affected...
January 15, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29334686/fat-mass-and-obesity-related-gene-variants-rs9939609-and-rs7185735-are-associated-with-second-generation-antipsychotic-induced-weight-gain
#3
Charlotte Schröder, Fabian Czerwensky, Stefan Leucht, Werner Steimer
INTRODUCTION: Weight gain is a limiting and frequent adverse effect of second-generation antipsychotic therapy. Identifying genetic risk factors would significantly improve pharmacotherapy. METHODS: We focused on rs7185735 and rs9939609, 2 common single nucleotide polymorphisms of the fat mass and obesity-associated (FTO) gene reported to be associated with obesity. Three-hundred fifty Caucasian inpatients were included in a naturalistic study. RESULTS: After 4 weeks of treatment, we did not observe any significant association of polymorphisms with weight change in the whole study population (p>0...
January 15, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29325180/sertindole-eeg-analysis-tolerability-and-clinical-efficacy
#4
Adam Kroc, Marta Dębicka, Aleksandra Wierzbicka, Lidia Wołkow, Wojciech Jernajczyk, Adam Wichniak
INTRODUCTION: One of the common side effects of antipsychotic drugs is excessive sedation. The treatment with antipsychotics often manifests as an increase in slow wave activity in electroencephalography (EEG). The aim of this study was to analyze EEG recordings of patients treated with a non-sedative antipsychotic drug sertindole with regard to its adverse effects and clinical efficacy. PATIENTS AND METHODS: EEG recordings of 45 patients (27 females, mean age 30...
January 11, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29270949/clinical-perspectives-of-lithium-s-neuroprotective-effect
#5
Janusz K Rybakowski, Aleksandra Suwalska, Tomas Hajek
Evidence for a neuroprotective effect of lithium has accumulated over the last 2 decades, and this phenomenon has been regarded as an important mechanism of lithium action in mood disorders. It has been reflected by an increase in cerebral gray matter volume in lithium-treated subjects and by the favorable influence of lithium on cognitive functions. A neuroprotective effect of lithium also makes this ion a possible candidate for use as a therapeutic drug in neurology, especially in neurodegenerative disorders...
December 21, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29258127/lithium-an-american-perspective
#6
Michael J Gitlin
No abstract text is available yet for this article.
December 19, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29179228/can-we-rely-on-agnp-therapeutic-targets-also-for-lai-antipsychotics
#7
Sara Baldelli, Emilio Clementi, Dario Cattaneo
The updated AGNP Consensus Guidelines for Therapeutic Drug Monitoring (TDM) in Neuropsychopharmacology recently published in the journal have reinforced the key role of TDM to individualize psychoparmacological therapies in clinical practice. However, we believe, that these guidelines have missed the important opportunity to face with, and to provide useful information on, the emerging issue of long-acting injectable formulations of atypical antipsychotics. Specific therapeutic ranges also for these formulations should be included in the next AGNP guidelines...
November 27, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29141255/is-venlafaxine-more-effective-than-escitalopram-and-nortriptyline-in-the-management-of-painful-symptoms-in-patients-with-major-depression
#8
Jan Jaracz, Karolina Gattner, Krystyna Jaracz, Krystyna Górna, Jerzy Moczko, Joanna Hauser
Background Conflicting data regarding the efficacy of antidepressants of different mechanism of action on unexplained painful physical symptoms (UPPS) in depression have been published so far. Objective The aim of this study was to compare the impact of escitalopram (ESC), nortriptyline (NOR), and venlafaxine (VEN) on UPPS in patients with major depression. Materials and methods Sixty patients, participants in the GENDEP study, with a diagnosis of depression according to the ICD-10 criteria were randomly assigned to treatment with ESC (10-30 mg, mean dose 15...
November 15, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29141254/role-of-glutamatergic-system-in-obsessive-compulsive-disorder-with-possible-therapeutic-implications
#9
Přemysl Vlček, Jakub Polák, Martin Brunovský, Jiří Horáček
No abstract text is available yet for this article.
November 15, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29100251/memantine-augmentation-improves-symptoms-in-serotonin-reuptake-inhibitor-refractory-obsessive-compulsive-disorder-a-randomized-controlled-trial
#10
Atieh Modarresi, Mehdi Sayyah, Setareh Razooghi, Kaveh Eslami, Mohammadreza Javadi, Leila Kouti
Introduction There is a large body of evidence on the clinical benefits of augmentation therapy with glutamate-modulating agents, such as memantine in reducing OCD symptoms. Methods A double-blind, placebo-controlled trial was conducted on SRIrefractory OCD patients. Thirty-two patients were randomized to receive either 20 mg/day memantine or placebo augmentation and were visited at baseline and every 4 weeks for 12 weeks. Results were measured using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Results The Y-BOCS total score was significantly reduced in the memantine group at the end of weeks 8 and 12, while no improvement was observed in the placebo group throughout the trial...
November 3, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28675911/patients-knowledge-about-prescribed-antipsychotics-and-medication-adherence-in-schizophrenia-a-cross-sectional-survey
#11
Nobuhiro Nagai, Hideaki Tani, Takefumi Suzuki, Saeko Ikai, Philip Gerretsen, Masaru Mimura, Hiroyuki Uchida
Introduction Data on the knowledge about antipsychotic medications prescribed in patients with schizophrenia are very limited. Moreover, it remains unclear how patients' knowledge about prescribed antipsychotics affects medication adherence. Methods ighty-one Japanese outpatients with schizophrenia according to the International Classification of Diseases, 10th edition, were included. Patients' knowledge of the primary antipsychotics prescribed to them in terms of therapeutic effects, type, and implicated neurotransmitters was assessed with a multiple-choice questionnaire developed for this study...
November 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28641333/validation-of-brain-angiotensin-system-blockade-as-a-novel-drug-target-in-pharmacological-treatment-of-neuropsychiatric-disorders
#12
Dominik Wincewicz, Jan J Braszko
Retreat in psychiatric drug development results in innovative medication decline that might be at least partially overcome by adjunct therapy. New evidence from clinical studies has shown a possible role for brain Renin-Angiotensin System (RAS) in both affective and psychotic disorders. Simultaneously, rapidly accumulating data from basic studies indicate effectiveness of central RAS blockade in much broader range of neuropsychiatric disease. Recent findings implicate brain RAS, especially Angiotensin II (Ang II), in neural pathophysiology of mental disorders through neuroendocrine modulation and effects on neurotransmitter release, mostly noradrenaline, acetylcholine and dopamine...
November 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28561203/relationship-between-daily-dose-serum-concentration-and-clinical-response-to-quetiapine-in-children-and-adolescents-with-psychotic-and-mood-disorders
#13
Laura Albantakis, Karin Egberts, Rainer Burger, Christine Kulpok, Claudia Mehler-Wex, Regina Taurines, Stefan Unterecker, Christoph Wewetzer, Marcel Romanos, Manfred Gerlach
Introduction In child and adolescent psychiatry, therapeutic drug monitoring (TDM) is strongly recommended. However, therapeutic ranges (TR) are defined only for adults. The objectives of this naturalistic study were to assess the relationships between serum quetiapine concentration, daily dose, and clinical outcomes as well as the determinants of pharmacokinetic variability. Furthermore, it was elucidated whether the recommended TR for adult patients with psychotic disorders is valid for children and adolescents...
November 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28482360/new-onset-of-suicidal-impulses-following-abrupt-cessation-of-valproate
#14
Johannes Ladwig, Dorothea Andreae, Renate Grohmann, Sermin Toto, Stefan Kropp, Stefan Bleich
No abstract text is available yet for this article.
November 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28444658/comparing-the-immune-genomic-effects-of-vilazodone-and-paroxetine-in-late-life-depression-a-pilot-study
#15
Harris Eyre, Prabha Siddarth, Natalie Cyr, Hongyu Yang, Steve Cole, Malcolm Forbes, Helen Lavretsky
Vilazodone is a novel antidepressant agent that combines selective serotonin (5-HT) reuptake inhibitor (SSRI) activity and 5-HT(1A) receptor partial agonist activity. A pilot study was conducted to compare vilazodone (novel compound) and paroxetine (gold standard) on antidepressant effects, tolerability, and inflammation and immune modulation. A 12-week, double-blind, randomized clinical trial was conducted with 56 nondemented older adults diagnosed with major depressive disorder (MDD). Between-group differences in mood, tolerability, and safety, as well as genomic markers of inflammation and immune modulation, were examined...
November 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29050056/drink-and-think-impact-of-alcohol-on-cognitive-functions-and-dementia-evidence-of-dose-related-effects
#16
Stefan Gutwinski, Stefanie Schreiter, Josef Priller, Jonathan Henssler, Corinde E Wiers, Andreas Heinz
No abstract text is available yet for this article.
October 19, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28950396/role-of-glutamatergic-system-in-obsessive-compulsive-disorder-with-possible-therapeutic-implications
#17
Přemysl Vlček, Jakub Polák, Martin Brunovský, Jiří Horáček
Obsessive-compulsive disorder (OCD) is a chronic psychiatric illness and 1 of the most common anxiety disorders with the prevalence of 3%. Although its pathogenesis remains unclear, the traditional model focused on alternations in the serotonin system. Selective serotonin reuptake inhibitors provide the most effective treatment; however, as much as 40-60% of patients do not respond to antidepressants therapy. Thus, attention has shifted towards other neurotransmitter systems and related neuroanatomical structures...
September 26, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28950395/drink-and-think-impact-of-alcohol-on-cognitive-functions-and-dementia-evidence-of-dose-related-effects
#18
Stefan Gutwinski, Stefanie Schreiter, Josef Priller, Jonathan Henssler, Corinde E Wiers, Andreas Heinz
Regular alcohol consumption affects cognitive performance and the development of dementia. So far, findings are contradicting, which might be explained in part by dose-related effects. For this narrative review, we undertook a literature search for surveys investigating the impact of alcohol consumption on cognitive performance and the development of dementia. The majority of studies observed a U-shaped relationship between regular alcohol consumption and cognitive function: frequent heavy consumption of alcohol alters brain functions and decreases cognitive performance; regular light and moderate consumption may have protective impact...
September 26, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28950394/what-characterizes-depression-in-old-age-results-from-the-bruneck-study
#19
Michaela Defrancesco, Raimund Pechlaner, Stefan Kiechl, Johann Willeit, Eberhard A Deisenhammer, Hartmann Hinterhuber, Gregor Rungger, Arno Gasperi, Josef Marksteiner
Introduction Depression in old age is associated with functional disabilities, cognitive impairment, lower self-rated quality of life, and increased mortality. The aim of the study was to reveal the prevalence of depression and to investigate the characteristics of patients treated with antidepressants. Methods We analyzed data from the Bruneck Study 2010. All participants completed a clinical examination, cognitive screening, the 30-item Geriatric Depression Scale (GDS) (cutoff score of>8 to define relevant depressive symptoms), and the World Health Organization quality of life questionnaire (WHO-QoL)...
September 26, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28926859/editorial-to-consensus-guidelines-for-therapeutic-drug-monitoring-in-neuropsychopharmacology
#20
Gerhard Gründer
No abstract text is available yet for this article.
September 19, 2017: Pharmacopsychiatry
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