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Pharmacopsychiatry

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https://www.readbyqxmd.com/read/29141255/is-venlafaxine-more-effective-than-escitalopram-and-nortriptyline-in-the-management-of-painful-symptoms-in-patients-with-major-depression
#1
Jan Jaracz, Karolina Gattner, Krystyna Jaracz, Krystyna Górna, Jerzy Moczko, Joanna Hauser
Background Conflicting data regarding the efficacy of antidepressants of different mechanism of action on unexplained painful physical symptoms (UPPS) in depression have been published so far. Objective The aim of this study was to compare the impact of escitalopram (ESC), nortriptyline (NOR), and venlafaxine (VEN) on UPPS in patients with major depression. Materials and methods Sixty patients, participants in the GENDEP study, with a diagnosis of depression according to the ICD-10 criteria were randomly assigned to treatment with ESC (10-30 mg, mean dose 15...
November 15, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29141254/role-of-glutamatergic-system-in-obsessive-compulsive-disorder-with-possible-therapeutic-implications
#2
Přemysl Vlček, Jakub Polák, Martin Brunovský, Jiří Horáček
No abstract text is available yet for this article.
November 15, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29100251/memantine-augmentation-improves-symptoms-in-serotonin-reuptake-inhibitor-refractory-obsessive-compulsive-disorder-a-randomized-controlled-trial
#3
Atieh Modarresi, Mehdi Sayyah, Setareh Razooghi, Kaveh Eslami, Mohammadreza Javadi, Leila Kouti
Introduction There is a large body of evidence on the clinical benefits of augmentation therapy with glutamate-modulating agents, such as memantine in reducing OCD symptoms. Methods A double-blind, placebo-controlled trial was conducted on SRIrefractory OCD patients. Thirty-two patients were randomized to receive either 20 mg/day memantine or placebo augmentation and were visited at baseline and every 4 weeks for 12 weeks. Results were measured using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Results The Y-BOCS total score was significantly reduced in the memantine group at the end of weeks 8 and 12, while no improvement was observed in the placebo group throughout the trial...
November 3, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29050056/drink-and-think-impact-of-alcohol-on-cognitive-functions-and-dementia-evidence-of-dose-related-effects
#4
Stefan Gutwinski, Stefanie Schreiter, Josef Priller, Jonathan Henssler, Corinde E Wiers, Andreas Heinz
No abstract text is available yet for this article.
October 19, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28950396/role-of-glutamatergic-system-in-obsessive-compulsive-disorder-with-possible-therapeutic-implications
#5
Přemysl Vlček, Jakub Polák, Martin Brunovský, Jiří Horáček
Obsessive-compulsive disorder (OCD) is a chronic psychiatric illness and 1 of the most common anxiety disorders with the prevalence of 3%. Although its pathogenesis remains unclear, the traditional model focused on alternations in the serotonin system. Selective serotonin reuptake inhibitors provide the most effective treatment; however, as much as 40-60% of patients do not respond to antidepressants therapy. Thus, attention has shifted towards other neurotransmitter systems and related neuroanatomical structures...
September 26, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28950395/drink-and-think-impact-of-alcohol-on-cognitive-functions-and-dementia-evidence-of-dose-related-effects
#6
Stefan Gutwinski, Stefanie Schreiter, Josef Priller, Jonathan Henssler, Corinde E Wiers, Andreas Heinz
Regular alcohol consumption affects cognitive performance and the development of dementia. So far, findings are contradicting, which might be explained in part by dose-related effects. For this narrative review, we undertook a literature search for surveys investigating the impact of alcohol consumption on cognitive performance and the development of dementia. The majority of studies observed a U-shaped relationship between regular alcohol consumption and cognitive function: frequent heavy consumption of alcohol alters brain functions and decreases cognitive performance; regular light and moderate consumption may have protective impact...
September 26, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28950394/what-characterizes-depression-in-old-age-results-from-the-bruneck-study
#7
Michaela Defrancesco, Raimund Pechlaner, Stefan Kiechl, Johann Willeit, Eberhard A Deisenhammer, Hartmann Hinterhuber, Gregor Rungger, Arno Gasperi, Josef Marksteiner
Introduction Depression in old age is associated with functional disabilities, cognitive impairment, lower self-rated quality of life, and increased mortality. The aim of the study was to reveal the prevalence of depression and to investigate the characteristics of patients treated with antidepressants. Methods We analyzed data from the Bruneck Study 2010. All participants completed a clinical examination, cognitive screening, the 30-item Geriatric Depression Scale (GDS) (cutoff score of>8 to define relevant depressive symptoms), and the World Health Organization quality of life questionnaire (WHO-QoL)...
September 26, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28926859/editorial-to-consensus-guidelines-for-therapeutic-drug-monitoring-in-neuropsychopharmacology
#8
Gerhard Gründer
No abstract text is available yet for this article.
September 19, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28922669/a-critical-commentary-on-the-2017-agnp-consensus-guidelines-for-therapeutic-drug-monitoring-in-neuropsychopharmacology
#9
Jose de Leon
In 2004, 2011, and 2017, the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP), a group of German-speaking psychiatric researchers and psychiatrists, published successive versions of therapeutic drug monitoring (TDM) expert group consensus guidelines. The 2017 version has as a major strength its encyclopedic nature, including 1358 references. The guideline has 3 major sections: 1) theoretical aspects of TDM, 2) drug concentration levels in blood to guide neuropsychopharmacotherapy, and 3) practical aspects of TDM in psychiatry and neurology...
September 18, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28910830/consensus-guidelines-for-therapeutic-drug-monitoring-in-neuropsychopharmacology-update-2017
#10
C Hiemke, N Bergemann, H W Clement, A Conca, J Deckert, K Domschke, G Eckermann, K Egberts, M Gerlach, C Greiner, G Gründer, E Haen, U Havemann-Reinecke, G Hefner, R Helmer, G Janssen, E Jaquenoud, G Laux, T Messer, R Mössner, M J Müller, M Paulzen, B Pfuhlmann, P Riederer, A Saria, B Schoppek, G Schoretsanitis, M Schwarz, M Silva Gracia, B Stegmann, W Steimer, J C Stingl, M Uhr, S Ulrich, S Unterecker, R Waschgler, G Zernig, G Zurek, P Baumann
Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug concentrations in blood to optimize pharmacotherapy. It considers the interindividual variability of pharmacokinetics and thus enables personalized pharmacotherapy. In psychiatry and neurology, patient populations that may particularly benefit from TDM are children and adolescents, pregnant women, elderly patients, individuals with intellectual disabilities, patients with substance abuse disorders, forensic psychiatric patients or patients with known or suspected pharmacokinetic abnormalities...
September 14, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28859206/beta-blockers-and-evidence-based-guidelines-for-the-pharmacological-management-of-acute-methamphetamine-related-disorders-and-toxicity
#11
John R Richards
No abstract text is available yet for this article.
August 31, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28850959/epileptic-seizures-under-antidepressive-drug-treatment-systematic-review
#12
Tilman Steinert, Walter Fröscher
Objective This paper is a systematic review on seizures under treatment with substances licensed for major depression. Method Systematic review protocol is available in PROSPERO registration number CRD42016034010. Twenty-five substances were selected according to frequencies of prescriptions and publications. A PubMed search was conducted with "substance name" and "seizure." Results A total of 2291 articles were screened, out of which 164 fulfilled inclusion criteria. Data synthesis was possible only to a limited extent due to heterogeneity of included patients, observation periods, methods, and outcomes...
August 29, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28675911/patients-knowledge-about-prescribed-antipsychotics-and-medication-adherence-in-schizophrenia-a-cross-sectional-survey
#13
Nobuhiro Nagai, Hideaki Tani, Takefumi Suzuki, Saeko Ikai, Philip Gerretsen, Masaru Mimura, Hiroyuki Uchida
Introduction Data on the knowledge about antipsychotic medications prescribed in patients with schizophrenia are very limited. Moreover, it remains unclear how patients' knowledge about prescribed antipsychotics affects medication adherence. Methods ighty-one Japanese outpatients with schizophrenia according to the International Classification of Diseases, 10th edition, were included. Patients' knowledge of the primary antipsychotics prescribed to them in terms of therapeutic effects, type, and implicated neurotransmitters was assessed with a multiple-choice questionnaire developed for this study...
November 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28641333/validation-of-brain-angiotensin-system-blockade-as-a-novel-drug-target-in-pharmacological-treatment-of-neuropsychiatric-disorders
#14
Dominik Wincewicz, Jan J Braszko
Retreat in psychiatric drug development results in innovative medication decline that might be at least partially overcome by adjunct therapy. New evidence from clinical studies has shown a possible role for brain Renin-Angiotensin System (RAS) in both affective and psychotic disorders. Simultaneously, rapidly accumulating data from basic studies indicate effectiveness of central RAS blockade in much broader range of neuropsychiatric disease. Recent findings implicate brain RAS, especially Angiotensin II (Ang II), in neural pathophysiology of mental disorders through neuroendocrine modulation and effects on neurotransmitter release, mostly noradrenaline, acetylcholine and dopamine...
November 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28561203/relationship-between-daily-dose-serum-concentration-and-clinical-response-to-quetiapine-in-children-and-adolescents-with-psychotic-and-mood-disorders
#15
Laura Albantakis, Karin Egberts, Rainer Burger, Christine Kulpok, Claudia Mehler-Wex, Regina Taurines, Stefan Unterecker, Christoph Wewetzer, Marcel Romanos, Manfred Gerlach
Introduction In child and adolescent psychiatry, therapeutic drug monitoring (TDM) is strongly recommended. However, therapeutic ranges (TR) are defined only for adults. The objectives of this naturalistic study were to assess the relationships between serum quetiapine concentration, daily dose, and clinical outcomes as well as the determinants of pharmacokinetic variability. Furthermore, it was elucidated whether the recommended TR for adult patients with psychotic disorders is valid for children and adolescents...
November 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28482360/new-onset-of-suicidal-impulses-following-abrupt-cessation-of-valproate
#16
Johannes Ladwig, Dorothea Andreae, Renate Grohmann, Sermin Toto, Stefan Kropp, Stefan Bleich
No abstract text is available yet for this article.
November 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28444658/comparing-the-immune-genomic-effects-of-vilazodone-and-paroxetine-in-late-life-depression-a-pilot-study
#17
Harris Eyre, Prabha Siddarth, Natalie Cyr, Hongyu Yang, Steve Cole, Malcolm Forbes, Helen Lavretsky
Vilazodone is a novel antidepressant agent that combines selective serotonin (5-HT) reuptake inhibitor (SSRI) activity and 5-HT(1A) receptor partial agonist activity. A pilot study was conducted to compare vilazodone (novel compound) and paroxetine (gold standard) on antidepressant effects, tolerability, and inflammation and immune modulation. A 12-week, double-blind, randomized clinical trial was conducted with 56 nondemented older adults diagnosed with major depressive disorder (MDD). Between-group differences in mood, tolerability, and safety, as well as genomic markers of inflammation and immune modulation, were examined...
November 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28905986/gearing-up-for-the-pearl-anniversary-agnp-set-to-hold-its-30th-meeting-in-munich-october-4%C3%A2-6-2017-overview-and-abstracts
#18
Golo Kronenberg, Jens Wiltfang, Johannes Thome
No abstract text is available yet for this article.
September 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28898894/editorial-to-driving-ability-and-psychotropic-drugs
#19
Gerd Laux, Michael Bauer
No abstract text is available yet for this article.
September 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28718182/driving-under-the-influence-of-antidepressants-a-systematic-review-and-update-of-the-evidence-of-experimental-and-controlled-clinical-studies
#20
Alexander Brunnauer, Gerd Laux
Introduction This review provides an update of experimental and clinical studies on the effects of antidepressants on driving performance. Methods A systematic literature search on the PubMed database (1980-2016) was performed. Results Twenty-eight studies could be included in this review, whereas only 5 studies investigated driving performance under antidepressants in patients. Most tri- and tetracyclics have acute deleterious effects on driving performance that, except for mianserin, attenuate after subchronic use...
September 2017: Pharmacopsychiatry
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