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Blood Purification

Thomas Jouve, Raphaël Marlu, Paolo Malvezzi, Landry Seyve, Jocelyne Maurizi, Pierre-Louis Carron, Benoît Polack, Lionel Rostaing
BACKGROUND/AIMS: Antibody-mediated rejection (AMR) is related to circulating donor-specific anti-human leukocyte antigen alloantibodies (DSAs). DSAs can be removed by apheresis, for example, double-filtration plasmapheresis (DFPP). However, DFPP removes some clotting factors (fibrinogen and factor XIII [FXIII]). METHODS: This was a prospective trial including 6 DSA-mediated AMR kidney transplant recipients. Patients received 2 cycles of 3-4 consecutive DFPP sessions followed by 1 injection of rituximab (break of 4-5 days between the 2 cycles)...
July 4, 2018: Blood Purification
Gaetano La Manna, Gabriele Donati
Coupled plasma filtration adsorption (CPFA) is a detoxification system that combines a plasma adsorption circuit with a continuous renal replacement therapy. The circuit consists of a plasma filter, a resin/adsorbent cartridge and a haemofilter. It differs from many other types of extracorporeal therapies in that the upper part of the circuit can be considered a "closed loop". In this manner, the plasma separated by the plasma filter passes through an adsorbent cartridge containing a resin with high affinity to many cytokines, mediators and toxins/poisons...
July 4, 2018: Blood Purification
Dana Mahmood, Bernd G Stegmayr
Anticoagulation with citrate-containing haemodialysate (cHD) is an alternative to tinzaparin haemodialysate (tHD). The study investigated whether cHD would differ when changed from tHD. The same 18 patients were their own controls followed up with cHD for 5 months. LDL-cholesterol decreased at the end of a cHD session (p = 0.01). Neutrophils (p = 0.013) and monocytes (p = 0.007) dropped more during a cHD session. During the follow-up period of cHD, approximately 50% needed additional tinzaparin. Before the cHD session could start, there was a lower total cholesterol at 2 weeks (p = 0...
July 4, 2018: Blood Purification
Sanjeet Balgobin, Marion Morena, Vincent Brunot, Noemie Besnard, Delphine Daubin, Laura Platon, Romaric Larcher, Laurent Amigues, Liliane Landreau, Anne-Sophie Bargnoux, Anne-Marie Dupuy, Jean-Paul Cristol, Kada Klouche
AIMS: High cut-off (HCO) continuous veno-venous hemodialysis (CVVHD) was compared to high-flux membrane (HFM) continuous veno-venous hemodiafiltration (CVVHDF) in intensive care unit (ICU) acute kidney injury (AKI) in terms of efficiency, hemodynamic tolerance, medium-sized molecules removal, albumin loss, and inflammatory system activation. METHODS: In a prospective cross-over randomized study, 10 AKI patients underwent successively HCO (Ultraflux EmiC2: β2-microglobulin [β2M] sieving coefficient [SC]: 0...
July 4, 2018: Blood Purification
Li Zhou, Shaobin Yu, Shenju Gou, Min Shi, Tianlei Cui, Ping Fu
No abstract text is available yet for this article.
July 4, 2018: Blood Purification
Chizuru Yamashita, Kazuhiro Moriyama, Daisuke Hasegawa, Yu Kato, Toshikazu Sakai, Takahiro Kawaji, Yasuyo Shimomura, Yasuyoshi Kurimoto, Mariko Nagata, Osamu Nishida
BACKGROUND: Polymyxin B-immobilized fiber (PMX-F) columns are used as therapeutic interventions for septic shock. The clinical efficacy has been reported for 2-h applications, but their ability to adsorb endotoxin over longer treatments has not been fully elucidated. We hypothesized that PMX-F columns are capable of endotoxin removal for more than 2 h. METHOD: We designed closed circuits incorporating either a PMX-F column with an 8.5-mL priming volume (PMX-01R) or a sham-control column, and used inactivated fetal bovine serum as the circulating perfusate...
July 3, 2018: Blood Purification
Muhammad Nauman Hashmi, Hammad Raza, Wael Elshazly, Fayez Hejaili, Abdullah Al Sayyari
OBJECTIVE: To develop a simple, objective, cheap scoring tool incorporating nutritional parameters and other variables to predict hospitalization and mortality among hemodialysis patients - a tool that could be utilized in low resource countries. METHODS: The following variables were scored according to severity into 0, 1, 2 or 3: BMI, functional capacity, HD vintage in years, serum albumin, serum ferritin, and the number of comorbid conditions (diabetes mellitus, hypertension, ischemic heart disease, cerebrovascular disease)...
July 3, 2018: Blood Purification
Giorgio Berlot, Stefano Falini, Virginia Negro, Antoinette Agbedjro, Ariella Tomasini, Fulvio Iscra, Francesco Bianco, Ugo Gerini, Giuliano Boscutti
BACKGROUND: The extracorporeal removal of mediators is a rescue strategy for septic shock patients, which is still under investigation. Several techniques are available: coupled plasma filtration and adsorption (CPFA) combines plasma processing with renal replacement therapy. METHODS: The study aimed to elucidate the role of both timing of initiation and intensity of treatment on the outcome, for which we retrospectively studied 52 patients. We collected the overall pre-CPFA time interval, starting from the first episode of hypotension in the wards and the volume of processed plasma (Vp), which we used as a proxy for intensity of treatment...
July 3, 2018: Blood Purification
Marcus Broman, Max Bell, Olivier Joannes-Boyau, Claudio Ronco
BACKGROUND/AIMS: We assessed how the novel PrisMax continuous renal replacement therapy (CRRT) system performed in a prospective international multicentre setting. We compared this device to its predecessor, the Prismaflex, with regards to multiple treatment parameters. Additionally, we performed a survey, aiming to measure user satisfaction. METHODS: Data was prospectively collected from 7 intensive care units (ICU) in 6 countries. The PrisMax device data logs constituted the raw material...
June 19, 2018: Blood Purification
Diego Pomarè Montin, Ghada Ankawi, Anna Lorenzin, Mauro Neri, Carlotta Caprara, Claudio Ronco
BACKGROUND/AIMS: The use of adsorption cartridges for hemoperfusion (HP) is rapidly evolving. For these devices, the potential induced cytotoxicity is an important issue. The aim of this study was to investigate potential in vitro cytotoxic effects of different sorbent cartridges, HA130, HA230, HA330, HA380 (Jafron, China), on U937 monocytes. METHODS: Monocytes were exposed to the sorbent material in static and dynamic manners. In static test, cell medium samples were collected after 24 h of incubation in the cartridges...
June 8, 2018: Blood Purification
(no author information available yet)
No abstract text is available yet for this article.
June 8, 2018: Blood Purification
Anna Lorenzin, Mauro Neri, Andrea Lupi, Martina Todesco, Monica Santimaria, Alberta Alghisi, Alessandra Brendolan, Claudio Ronco
BACKGROUND: Inadequate removal of molecules between 5 and 50 KDa may cause long-term complication in chronic hemodialysis. Medium cut-off (MCO) is a new class of membranes with enhanced sieving properties and negligible albumin loss. MCO membrane makes it possible to perform expanded hemodialysis (HDx), a technique based on high internal filtration (IF).The present study is designed to quantify IF in 2 MCO dialyzers (Theranova 400 and 500, Baxter, Deerfield, USA) using a nuclear imaging technique previously validated...
June 8, 2018: Blood Purification
Gianluca Villa, Mauro Neri, Silvia De Rosa, Sara Samoni, Cosimo Chelazzi, Stefano Romagnoli, Anna Lorenzin, Massimo de Cal, Claudio Ronco, Angelo Raffaele De Gaudio
BACKGROUND: Convective therapies with high cut-off membranes (HCO) are usually not recommended because of theoretical excessive albumin loss. The aim of this in vitro study is to demonstrate the noninferior safety of pre-dilution hemodiafiltration with HCO (HCO-CVVHDF) with isotonic citrate anticoagulation (18 mmol/L) with respect to heparin anticoagulated hemodialysis with HCO (HCO-CVVHD) in terms of albumin removal and citrate load. METHOD: -Albumin removal was compared in vitro between 3 pre--dilution-HCO-CVVHDF with citrate anticoagulation and 3 -HCO-CVVHD with heparin anticoagulation during 30-min single-pass and 180-min recirculation phases...
June 8, 2018: Blood Purification
Gioacchino Li Cavoli, Onofrio Schillaci, Carmela Zagarrigo, Tancredi Vincenzo Li Cavoli, Barbara Oliva, Angelo Tralongo, Franca Servillo, Flavia Caputo
No abstract text is available yet for this article.
May 4, 2018: Blood Purification
Grzegorz Kade, Sławomir Literacki, Agnieszka Rzeszotarska, Stanisław Niemczyk, Arkadiusz Lubas
INTRODUCTION: The purpose of this study was to evaluate the impact of continuous veno-venous hemodialysis (CVVHD) using high cutoff (HCO) hemofilters on the removal of procalcitonin (PCT), and other inflammatory markers in the treatment of patients during septic shock with acute kidney injury (AKI). MATERIALS AND METHODS: Thirty-six patients with septic shock and AKI were included in the study. Before and after the 24-h HCO-CVVHD, PCT, native C-reactive protein (CRP) and cytokines (interleukin-1β, interleukin-6, interleukin-12, interleukin-17, tumor necrosis factor-α) in serum and effluent were assessed...
2018: Blood Purification
Mustafa C Bulbul, Tuncay Dagel, Baris Afsar, Nuray N Ulusu, Masanari Kuwabara, Adrian Covic, Mehmet Kanbay
Cardiovascular disease (CVD) is the leading cause of death in chronic kidney disease (CKD). One of the most important pathophysiological mechanisms for CVD in patients with CKD is the widespread and possibly accelerated formation of atherosclerotic plaques due to hyperlipidemia, uremic toxins, inflammation, oxidative stress, and endothelial dysfunction. Recent studies showed that the level of oxidized low-density lipoprotein cholesterol increases, and that high--density lipoprotein cholesterol dysfunction occurs as kidney function declines and inflammation becomes more prevalent...
2018: Blood Purification
Takashi Honma
No abstract text is available yet for this article.
2018: Blood Purification
Benjamin Koch, Patricia Schult-Dietrich, Stefan Büttner, Bijan Dilmaghani, Dario Lohmann, Patrick C Baer, Ursula Dietrich, Helmut Geiger
BACKGROUND/AIMS: Middle East respiratory syndrome coronavirus (MERS-CoV) and Marburg virus (MARV) are among the World Health Organization's top 8 emerging pathogens. Both zoonoses share nonspecific early symptoms, a high lethality rate, and a reduced number of specific treatment options. Therefore, we evaluated extracorporeal virus and glycoprotein (GP) elimination by lectin affinity plasmapheresis (LAP). METHODS: For both MERS-CoV (pseudovirus) as well as MARV (GPs), 4 LAP devices (Mini Hemopurifiers, Aethlon Medical, San Diego, CA, USA) and 4 negative controls were tested...
2018: Blood Purification
Tadayuki Kawasaki
No abstract text is available yet for this article.
2018: Blood Purification
Tomotaka Naramura
No abstract text is available yet for this article.
2018: Blood Purification
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