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Asian Pacific Journal of Allergy and Immunology

Nathnarin Somchit, Rungruedee Kimseng, Rana Dhar, Poonsit Hiransai, Chatchawan Changtam, Apichart Suksamrarn, Wilanee Chunglok, Warangkana Chunglok
BACKGROUND: Targeting inflammatory macrophages and their products is an effective method for controlling inflammation. The pyrazole analog of curcumin (curcumin pyrazole, PYR) has been reported to possess superior anti-inflammatory activity to curcumin (CUR). However, the role of PYR anti-inflammatory activity in macrophages has not yet been elucidated. OBJECTIVE: To examine the anti-inflammatory effects of PYR and CUR in lipopolysaccharide (LPS)-activated RAW 264...
December 16, 2017: Asian Pacific Journal of Allergy and Immunology
Sirasuda Sommanus, Chalerat Direkwattanachai, Saranath Lawpoolsri, Raweerat Sitcharungsi
BACKGROUND: The Childhood Asthma Control Test (C-ACT) was developed to assess asthma control in children worldwide. A self-administered questionnaire for children translated into Thai language was used. OBJECTIVE: To validate the C-ACT cut-points for evaluating the level of asthma control among Thai children, using the Global Initiative for Asthma (GINA) guideline as a gold standard. METHODS: C-ACT score, FEV1 and assessment of level of asthma control were recorded at baseline, 3-month, 6-month, and 1-year visits among children with asthma...
December 10, 2017: Asian Pacific Journal of Allergy and Immunology
Li-Ching Fang, Shyh-Dar Shyur, Jen-Yu Wang, Yu-Hsuan Kao, Chien-Hui Yang, Yu-Ting Yu
BACKGROUND: Aeroallergen sensitization may predict higher fractional exhaled nitric oxide (FeNO) levels. OBJECTIVE: We evaluate cut-off values of FeNO in asthmatic children with and without positive specific immunoglobulin E (IgE) to at least one of 5 aeroallergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat, dog, and cockroach). METHODS: 564 patients with asthma and allergic rhinitis (AR) aged 5 to 18 years were enrolled into two groups...
December 10, 2017: Asian Pacific Journal of Allergy and Immunology
Tak-Hong Lee, Ting-Fan Leung, Gary Wong, Marco Ho, Jaime Rosa Duque, Philip Hei Li, Chak-Sing Lau, Wai-Fan Lam, Adrian Wu, Eric Chan, Christopher Lai, Yu-Lung Lau
There is a high and rising prevalence of many allergic diseases in the Asia Pacific, including Hong Kong, which is unmatched by a commensurate provision of clinical allergy services. In the last 3 years, the allergy profile in Hong Kong has increased due to greater public engagement and more frequent educational activities, scientific outputs and publication of local guidelines on allergy prevention, diagnosis and treatment. Two new drug allergy clinics have been established in public hospitals, and for the first time in 20 years, Hong Kong has its first trainee in adult allergy...
December 10, 2017: Asian Pacific Journal of Allergy and Immunology
Cassandra Balinas, Thao Nguyen, Samantha Johnston, Peter Smith, Donald Staines, Sonya Marshall-Gradisnik
BACKGROUND: Viral infections and hypersensitivities are commonly reported by Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients. Mast Cells (MC) uniquely mediate type 1 hypersensitivities and resolve viral infections via toll-like receptor 3 (TLR3). OBJECTIVE: To characterise and compare mast cell progenitors (MCPs) in CFS/ME participants with a known MC disorder, Systemic mastocytosis (SM), and secondly, to investigate the role of MC TLR3 in CFS/ME participants following Polyinosinic:polycytidylic acid (Poly I:C) stimulation...
December 10, 2017: Asian Pacific Journal of Allergy and Immunology
Witida Laopajon, Nuchjira Takheaw, Saichit Khummuang, Tanyaluck Kampoun, Kantinan Cheunsirikulchai, Watchara Kasinrerk, Supansa Pata
BACKGROUND: Soluble CD147 (sCD147) is the shed form of membrane-bound CD147, which is involved in the regulation of cellular functions. The presence of sCD147 in body fluids is associated with several diseases. OBJECTIVE: In this study, we aimed to establish antibody (Ab) biosensors for the simultaneous differential detection of the general and truncated forms of sCD147. METHOD: By combining biolayer interferometry technology (BLItz) and different anti-CD147 monoclonal antibodies (mAbs) specific to different extracellular domains of the CD147 molecule, Ab-based biosensors were established to rapidly measure and characterize sCD147 isoforms...
December 10, 2017: Asian Pacific Journal of Allergy and Immunology
Wipa Jessadapakorn, Pasuree Sangsupawanich, Natthakul Wootipoom, Oranart Suddeaugrai, Araya Yuenyongviwat
BACKGROUND AND OBJECTIVE: Component-resolved diagnostics (CRD) have garnered a lot of attention in recent years in the diagnosis of food allergies. We aimed to investigate sensitization against cow's milk and egg white components, and to study the clinical usefulness of serum food-specific immunoglobulin E (sIgE) to cow's milk and egg white components in Thai children with cow's milk and egg allergies. METHOD: Children with IgE-mediated cow's milk and/or egg allergy were enrolled...
December 2017: Asian Pacific Journal of Allergy and Immunology
Loida Recopuerto Medina, Nat Malainual, John Donnie Ramos
BACKGROUND: Blo t 5, a major allergen from the house dust mite Blomia tropicalis had been identified as an important trigger of allergic diseases. Effects of sequence variations to the IgE binding activity of Blo t 5 remain unclear. OBJECTIVE: The study determined gene polymorphisms of Blo t 5, expressed the recombinant Blo t 5 allergen in E. coli system and determined its IgE reactivity in house dust mite allergic Filipino patients. METHOD: Gene polymorphism was determined using Polymerase Chain Reaction and DNA sequencing...
December 2017: Asian Pacific Journal of Allergy and Immunology
Ratchaneewan Sinitkul, Wiparat Manuyakorn, Wasu Kamchaisatian, Soamarat Vilaiyuk, Suwat Benjaponpitak, Chatmanee Lertudompholwanit, Suporn Treepongkaruna
BACKGROUND: Food allergy (FA) prevalence is increasing in pediatric liver transplantation (LT). However, the clinical course is still limited. OBJECTIVE: This retrospective cohort study aimed to identify the prevalence, risk factors, and the natural history of de novo FA in children post LT. METHODS: Medical records of pediatric LT recipients from Jan 2001 - Dec 2014 were reviewed. De novo FA was diagnosed by symptoms after exposure to culprit food occurring after LT, and improvement after diet elimination...
November 22, 2017: Asian Pacific Journal of Allergy and Immunology
Kun Chen, Zhijian Yu, Jun Yang, Huabin Li
BACKGROUND: The cysteinyl leukotrienes (cysLTs) are proinflammatory lipid mediators that act on the type 1 cysLT receptor (CysLT1R) in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). GPR17, a G protein-coupled orphan receptor with homology to the cysLT receptors, has been proposed as a damage sensor during inflammation. However, the expression and correlation of GPR17 and CysLT1R in eosinophilic CRSwNP (ECRS) and non-eosinophilic CRSwNP (non-ECRS) have not been well investigated...
November 22, 2017: Asian Pacific Journal of Allergy and Immunology
Nualanong Visitsunthorn, Wanwipa Chaimongkol, Kittipos Visitsunthorn, Punchama Pacharn, Orathai Jirapongsananuruk
BACKGROUND: Flooding may affect aeroallergen sensitization. OBJECTIVE: To evaluate aeroallergen sensitization in children with asthma and/or allergic rhinitis (AR) by skin prick test (SPT) before and after the great flood of 2011 in Bangkok, Thailand. METHODS: The study was performed retrospectively in asthma and/or AR children (aged 0-18 years) in Siriraj Hospital, Bangkok, Thailand from 2009 to 2013. All of the cases received SPT with common aeroallergens...
November 22, 2017: Asian Pacific Journal of Allergy and Immunology
Theerasuk Kawamatawong, Orapan Poachanukoon, Chalermporn Boonsiri, Atik Saengasapaviriya, Atik Saengasapaviriya, Chanchai Sittipunt, Hiroshi Chantaphakul, Atik Saengasapaviriya, Kittipong Maneechotesuwan, Pintip Ngamchanyaporn, Kunchit Piyavechviratana, Praparn Yongjaiyut, Apichart Khanisap, Siwasak Juthong, Warangkana Rithirak, Prapaporn Pornsuriyasak, Chaicharn Pothirat, Watchara Boonsawat
BACKGROUND: To evaluate long-term effectiveness of omalizumab in 'real-life' setting of Thai asthmatic patients. METHODS: We conducted multi-center, observational study in severe asthma patients who received omalizumab in Thailand. Outcomes were asthma exacerbation (hospitalization and ER visit), asthma control test (ACT), and daily ICS dose. Data were evaluated at baseline, 16 Week, and 52 Week. RESULTS: A total of 78 patients received omalizumab treatment (average duration 16...
November 22, 2017: Asian Pacific Journal of Allergy and Immunology
Natalia Ukleja-Sokołowska, Ewa Gawrońska-Ukleja, Magdalena Żbikowska-Gotz, Łukasz Sokołowski, Zbigniew Bartuzi
Eggplant allergy is rare and most of the previously described reactions were mild. In this case report, we present an interesting case of a 27-year-old male who experienced symptoms of anaphylaxis (shortness of breath, and swelling of the face, lips and tongue, which was followed by hypotension, tachycardia of 140/min and a sudden loss of consciousness) several minutes after eating a dish containing backed eggplant. Previously, the patient had experienced symptoms of allergy after eating different types of food, such as salad and chicken in spices...
November 22, 2017: Asian Pacific Journal of Allergy and Immunology
Jongkonnee Wongpiyabovorn, Narissara Suratannon, Sadudee Boonmee, Pantipa Chatchatee
BACKGROUND: Diagnostic tools to identify allergens that cause allergic symptom is important part in the care of allergic patients. Detection of causative allergen can be performed by in vivo skin prick test (SPT) or in vitro tests for detection serum specific immunoglobulin E (sIgE). The common methods used are fluorescent enzyme assay and immunoblotting assay. OBJECTIVE: We aim to evaluate performance of the two sIgE determination systems, immunoblotting assay (Euroline) and fluorescent enzyme assay (ImmunoCAP) in comparison with SPT...
September 17, 2017: Asian Pacific Journal of Allergy and Immunology
Thitigun Jaimipak, Sutee Yoksan, Sukathida Ubol, Rojjanaporn Pulmanausahakul
BACKGROUND: Plaque size is a common feature of viral characterization. Small plaque size is used as a marker of attenuation for live-attenuated vaccine development. OBJECTIVE: To investigate whether the naturally occurring plaque size variation reflects virulence of the variants of chikungunya virus (CHIKV). METHODS: We selected and purified a variant with small plaque size from the primary isolate. The viral variant was tested for the plaque morphology, in vitro growth kinetics and mouse neurovirulence in comparison with the parental wild type...
September 17, 2017: Asian Pacific Journal of Allergy and Immunology
Sung Chul Seo, So Hyun Ahn, Soohyun Ri, Yoonsun Yoon, Jung Hye Byeon, Seung Hyun Kim, Wonsuck Yoon, Young Yoo
BACKGROUND: Recent data suggested that imbalance in gut microbiota and gastrointestinal inflammation are associated with the childhood allergic disease. Fecal calprotectin has been used for a non-invasive marker of gut inflammation. OBJECTIVE: The aim of this study was to investigate the relationships between fecal calprotectin level and the clinical severity of atopic dermatitis (AD) in children. METHODS: We enrolled 65 subjects with AD. The concentration of calprotectin was measured in each subject's fecal sample...
September 17, 2017: Asian Pacific Journal of Allergy and Immunology
Karaked Chantawarangul, Jitladda Deerojanawong, Suchada Sritippayawan
BACKGROUND: Although wheezing is very common in preschoolers, epidemiologic studies in Thailand are quite limited. The likelihood of having a second wheezing episode following the first attack remains unclearly established. OBJECTIVES: This study aims to investigate the incidence of recurrent wheezing in preschool children presenting with first wheezing episode and identify the associated factors. METHODS: The study is an observational prospective study conducted at the inpatient pediatric department...
September 17, 2017: Asian Pacific Journal of Allergy and Immunology
Wiparat Manuyakorn, Buntita Bamrungchaowkasem, Nichanan Ruangwattanapaisarn, Wasu Kamchaisatian, Suwat Benjaponpitak
BACKGROUND: Intramuscular epinephrine is the first line drug in the treatment of anaphylaxis. This study was to identify the appropriateness of 1 inch needle length for epinephrine prefilled syringes in children. METHODS: Children aged 1 month to 18 years were enrolled. Skin to muscle depth (STMD) and skin to bone depth (STBD) were measured using an ultrasonography at the mid-anterolateral thigh. A 1 inch needle was considered as being appropriate if the STBD was more than 1 inch and the STMD was less than 1 inch...
September 17, 2017: Asian Pacific Journal of Allergy and Immunology
Kingthong Lakupoch, Wiparat Manuyakorn, Aroonwan Preutthipan, Harutai Kamalaporn
BACKGROUND: Providing asthma education about controller medication use and appropriate management of asthma exacerbation are the keys to improving the disease outcome. Many asthma guidelines recommend that physicians provide written asthma action plan (WAAP) to all of their asthmatic patients. However, the benefit of WAAP is unclear. Thus, we have created a new WAAP which is simplified in Thai and more user friendly. OBJECTIVE: To determine the effectiveness of the newly developed asthma action plan in management of children with asthma...
September 17, 2017: Asian Pacific Journal of Allergy and Immunology
Seςil Kepil Özdemir, Selcan Özgüςlü
BACKGROUND: There is limited data regarding pollen food allergy syndrome (PFAS) in Turkey. OBJECTIVES: To investigate the clinical characteristics and possible risk factors of PFAS in Turkey, and to evaluate if there was an association between skin test reactivity to pollens and presence of PFAS. METHODS: A total of 254 consecutive adult patients with pollen sensitivity were prospectively recruited. Patients were interviewed with a questionnaire including a list of pollen-associated foods...
September 17, 2017: Asian Pacific Journal of Allergy and Immunology
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