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Asian Pacific Journal of Allergy and Immunology

Kanon Jatuworapruk, Lantarima Bhoopat, Punchong Hanvivadhanakul
OBJECTIVES: To describe the characteristics of patients with antiphospholipid syndrome (APS) in an Asian clinical practice setting. METHODS: We conducted a single-center, retrospective study of APS patients attending the rheumatology or hematology clinics, between January 2012 and December 2016. RESULTS: There were 450 patients suspected of having APS referred to our clinics. Seventy-four (16.4%) were diagnosed of APS, 51% of which were definite...
July 8, 2018: Asian Pacific Journal of Allergy and Immunology
Panadda Suwan, Phatcharee Praphaiphin, Pantipa Chatchatee
BACKGROUND: Caregivers often incorrectly use epinephrine autoinjectors. It is unclear whether this is due to insufficient training or a difficult-to-use tool. Furthermore, the high costs of epinephrine autoinjectors may limit their availability; so low-cost prefilled syringes may be the alternative. OBJECTIVES AND METHODS: We performed a prospective randomized trial to compare successful epinephrine administration at four stages: after reading written instructions, and immediately after, 6 weeks, and 3 months following video training...
July 8, 2018: Asian Pacific Journal of Allergy and Immunology
Ya Ru Yan, Yan Hua Xu, Qing Zheng, Yin Shi Guo
BACKGROUND: The worldwide prevalence of allergic diseases has increased during the last few decades, but it is not well known about the sensitization profiles of adult patients in Shanghai. OBJECTIVE: This study aimed to identify the prevalence and sex difference of allergen sensitization among adult with allergic diseases in Shanghai. METHODS: The sensitization profiles of 7,996 patients (18-60 yrs old) with allergic diseases at our center were retrospectively analyzed, based on the results of skin prick tests...
July 8, 2018: Asian Pacific Journal of Allergy and Immunology
Mastura Md Sani, Noor Suryani Mohd Ashari, Baharudin Abdullah, Kah Keng Wong, Kamarul Imran Musa, Rohimah Mohamud, Hern-Tze Tina Tan
BACKGROUND: Terminally differentiated effector memory (TEMRA) T cells exert potent effector function after activation. The proportions of CD4+ T cell subsets especially memory cells in allergic rhinitis (AR) patients sensitized to house dust mites (HDMs) have not been extensively studied. OBJECTIVE: This study aimed to compare the mean percentages and absolute counts of CD4+ memory T cell subsets between: (i) non-allergic controls and AR patients; (ii) mild AR patients and moderate-severe AR patients...
July 8, 2018: Asian Pacific Journal of Allergy and Immunology
Jaime S Rosa Duque, Patrick Cy Chong, Yu-Lung Lau, Marco Hk Ho
A seven-year-old girl developed angioedema and a generalized, erythematous rash several hours after receiving lignocaine with adrenaline reproducible on provocative challenge, confirming the first known case of generalized delayed-type hypersensitivity to local anaesthetics with cross-reactivity to bupivacaine but not chloroprocaine.
July 8, 2018: Asian Pacific Journal of Allergy and Immunology
Thao Nguyen, Donald Staines, Samantha Johnston, Sonya Marshall-Gradisnik
BACKGROUND: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is medically unexplained post-exertional fatigue associated with significant reduction in natural killer cell (NK) cytotoxicity activity. Cytotoxic activity relies on glycolytic flux and mitochondrial respiration to fulfill energetic cellular demands. While mitochondrial dysfunction has been reported in ME/CFS patients, no previous investigation has examined the bioenergetic profile of isolated NK cells from ME/CFS patients...
July 8, 2018: Asian Pacific Journal of Allergy and Immunology
Butsabong Lerkvaleekul, Soamarat Vilaiyuk
BACKGROUND: Interleukin (IL)-6 is the main proinflammatory cytokine in systemic juvenile idiopathic arthritis (SJIA). OBJECTIVE: To determine if serial changes in serum IL-6 levels can predict outcomes of SJIA patients. METHODS: This was a retrospective cohort study. Medical records of patients aged 2-19 years with active SJIA between January 2012 and February 2014 were reviewed. Baseline characteristics were recorded at enrollment. Serum IL-6 levels were measured at enrollment and at 2-4 weeks, 6-8 weeks, 3 months, and 6 months thereafter...
June 11, 2018: Asian Pacific Journal of Allergy and Immunology
Kumpol Amnuaypattanapon, Chitlada Limjindaporn, Winchana Srivilaithon, Ittabud Dasanadeba
INTRODUCTION: The characteristics and treatment outcomes of status asthmaticus patients in emergency department (ED) have not been described previously especially in Thailand. OBJECTIVE: To describe the characteristics, treatment outcomes and factors associated with status asthmaticus in Thai patients presenting to a single center ED. METHODS: A prospective observational study was performed at Thammasat University hospital, Thailand. The data collected included demographics, asthma history and control, previous ED attendances and hospital admissions, presenting clinical, laboratory and radiographic features, treatments given, and outcomes...
June 11, 2018: Asian Pacific Journal of Allergy and Immunology
Wansu Chen, Michael Schatz, Zhi Liang, Qiaowu Li, Ekaterina Sadikova, Zilu Zhang, Shalini Bagga, Robert S Zeiger
BACKGROUND: Little is known concerning the relative effectiveness of LTRAs compared to ICSs as monotherapy or LABA as add-on therapy in the Asian population. OBJECTIVES: In this retrospective cohort study, we examined the comparative effectiveness of montelukast to ICS as a first-line monotherapy and as an add-on in comparison with LABA on asthma exacerbations among Asian and non-Hispanic white persistent asthma patients in a large managed care organization. METHODS: The three add-on comparisons were montelukast plus low-dose ICS versus LABA plus low-dose ICS, montelukast plus low-dose ICS versus medium-dose ICS, and montelukast plus medium-dose ICS versus LABA plus medium-dose ICS...
June 11, 2018: Asian Pacific Journal of Allergy and Immunology
Hwanhee Park, Ji Young Lee, Ari Song, Minyoung Jung, Minji Kim, Insuk Sohn, MinJi Kim, Joongbum Cho, Kangmo Ahn, Jihyun Kim
BACKGROUND: Chronic urticaria (CU) has an adverse effect on academic achievement and psychosocial development in children. OBJECTIVE: We aimed to investigate the natural course of CU and to identify relevant factors associated with a poor CU prognosis in Korean children. METHODS: We retrospectively analyzed 253 children with episodes of wheals or angioedema at least 3 times a week that persisted for at least 6 weeks. Clinical data and laboratory results were obtained from medical records and parental telephone interviews...
June 11, 2018: Asian Pacific Journal of Allergy and Immunology
Torpong Thongngarm, Adhiratha Boonyasiri, Panitan Pradubpongsa, Nattaporn Tesavibul, Tauangtham Anekpuritanang, Piyawut Kreetapirom, Mongkhon Sompornrattanaphan
BACKGROUND: Good syndrome (GS) is an adult-onset immunodeficiency characterized by coexisting thymoma and hypogammaglobulinemia. Clinical course after treatment with intravenous immunoglobulin (IVIg) has rarely been reported. OBJECTIVE: To investigate and report the clinical course and outcomes of GS patients after treatment with IVIg at Thailand's largest national tertiary referral hospital METHODS: This retrospective chart review included patients diagnosed with GS and treated with IVIg during the 1 January 2005 to 31 December 2015 study period...
June 11, 2018: Asian Pacific Journal of Allergy and Immunology
Yukihiro Hiramatsu, Daisuke Sakamoto, Tomomitsu Satho, Keiichi Irie, Fumio Miake, Minoru Maeda, Nobuhiro Kashige
BACKGROUND: Lactobacilli show anti-inflammatory effects in the human intestine, and their genomic DNA was identified as one of the anti-inflammatory components. Increased levels of the natural protease inhibitor elafin in the intestine plays an important role in protection against intestinal inflammation. However, there have been no previous reports regarding whether lactobacilli increase elafin levels. OBJECTIVE: This study was performed to investigate whether Lactobacillus plantarum induces elafin secretion from the human epithelial colorectal adenocarcinoma cell line, Caco-2...
June 11, 2018: Asian Pacific Journal of Allergy and Immunology
Miao Qing, Liu Yongge, Xu Wei, Wang Yan, Li Zhen, Ren Yixin, Guan Hui, Xiang Li
OBJECTIVE: To investigate whether there were differences in Th17 cells mediated immunological responses among asthmatics with or without allergic rhinitis. METHODS: A case-control comparison was conducted in a cohort of 67 children with asthma (AS), 50 children with allergic rhinitis (AR), 52 children with both AS and AR (ASR), 25 infectious rhinitis (IR), and 55 healthy controls (HC). The percentages of circulating Th17 cells were determined by flow cytometry. The Th2- and Th17-related cytokines in plasma and culture supernatants were measured by enzyme-linked immunosorbent assay...
March 31, 2018: Asian Pacific Journal of Allergy and Immunology
Xiaoxu Sun, Junwei Zhao, Qiuya Wang, Guang Shi, Jingjing Yang, Liang Ming
BACKGROUND: The prevalence of allergen sensitization varies in different geographic areas and population subsets. This study investigated the prevalence and distribution of inhaled and food allergens among allergic patients in Henan Province, China. METHOD: The prevalence and distribution of 19 inhaled and food allergens among 15,534 patients with suspected allergic diseases were retrospectively analyzed in Henan Province, China between December 2012 and August 2016...
March 31, 2018: Asian Pacific Journal of Allergy and Immunology
Soraya Sangjan, Silawun Ampol, Sutchana Tabprasit, Navin Horthongkham, Thippawan Chuenchitra, Pattama Ekpo, Wannee Kantakamalakul
BACKGROUND: There have been a few studies aimed at identifying epitopes of ADCC-inducing antibodies when compared to those of neutralizing antibodies and cytotoxic T lymphocytes against a variety of HIV-1 clades. OBJECTIVE: To map the common ADCC epitopes of HIV-1 CRF01_AE. METHODS: We screened 65 sera of confirmed early HIV-1 CRF01_AE infected individuals for ADCC antibody against gp120 utilizing an EGFP-CEM-NKr flow cytometric assay. Sera with high ADCC antibody were then examined against ADCC epitopes using the complete HIV-1 CRF01_AE gp160- and subtype A Gag-overlapping peptide sets which were divided into 7 pools:E1-E7 and 5 pools:G1-G5, respectively...
March 31, 2018: Asian Pacific Journal of Allergy and Immunology
Younghoon Kim, Inbo Kim, Choon-Ho Park, Jong Bae Kim
BACKGROUND: Natural killer (NK) cells are crucial components of the innate immune system, providing the first line of defense against pathogens. In a previous study, we demonstrated prophylactic activity of water extract of Korean mistletoe (Viscum album coloratum) on tumor metastasis. However, the leading compound from water extract of Korean mistletoe was not clearly addressed. OBJECTIVE: The purpose of this research was mainly focused on addressing the effect of Korean mistletoe lectin (KMLC) on NK cell cytotoxicity, and the ability of cytokine secretion as well as its signal transduction, mitogen-activated protein kinase (MAPK) pathway...
March 31, 2018: Asian Pacific Journal of Allergy and Immunology
Jung Won Yoon, Youn Ho Sheen, Eun Kyo Ha, Ji Hyun Baek, Hey Sung Baek, Sun Hee Choi, Man Yong Han
BACKGROUND: Small airway hyperresponsiveness is a critical aspect in preschool children with asthmatic symptoms interms of asthma control. The aim of this study was to elucidate the relationship of changes in reactance (Xrs) and resistance (Rrs) of IOS and FEV1 with those in clinical parameters and to determine which IOS parameter is correlated with bronchial hyperresponsiveness before positive clinical endpoints. METHODS: We performed the methacholine challenge test in ninety-four preschool children (4...
March 12, 2018: Asian Pacific Journal of Allergy and Immunology
Ping-Hsien Yang, Shyh-Dar Shyur, Ming-Jer Liu, Hsin-Hui Chuang
Buckwheat anaphylaxis is commonly recognized in Europe and Asia, and there is only one case reported in Taiwan so far. Here, we report a case of biphasic buckwheat anaphylaxis in a 57 year-old male patient who lost consciousness twice in the same day after having buckwheat noodles. The serum test shows that Dermatophagoides pteronyssinus (Dp)immunoglobulin E (IgE) (42.4 kU/L) and buckwheat-specific IgE (81.5 kU/L) are unusually high. Although biphasic buckwheat anaphylaxis is rare, we should still be aware the second episode could be life-threatening and happen within a day after the exposure to the buckwheat antigen...
March 12, 2018: Asian Pacific Journal of Allergy and Immunology
Federica Porcaro, Lucia Caminiti, Giuseppe Crisafulli, Francesco Guglielmo, Giovanni Battista Pajno
Children who are highly sensitive to milk may also have severe allergic reactions after exposure to cow's milk proteins(CMP) through a different administration route than the oral one. We describe the case of a 16-year-old Caucasian boy with a clinical history of persistent cow's milk allergy (CMA), who developed one episode of anaphylaxis following cutaneous application of a bovine colostrum containing cream to a surgical wound. UniCAP testing showed a significant elevation in specific IgE antibodies to whey milk proteins...
March 12, 2018: Asian Pacific Journal of Allergy and Immunology
Wannee Kantakamalakul, Suwalee Jangkhum, Silawun Ampol, Porurtai Burupharat, Rutt Chuachoowong, Ruengpung Sutthent, Kovit Pattanapanyasat
BACKGOUND: Intravenous drug users (IVDUs) are among the high-risk groups who are most vulnerable to HIV infection. Several illicit drugs alter host immune function with increased incidence of infections including that of HIV. Many studies of the immune response of NK cells in HIV-1 seronegative IVDUs and HIV-1 seropositive IVDUs have been published from the Western countries and yet no data is available from Thailand. OBJECTIVE: To determine natural killer cell cytotoxicity and lymphocyte subsets in Thai HIV-1 infected intravenous drug users...
March 12, 2018: Asian Pacific Journal of Allergy and Immunology
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