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Asian Pacific Journal of Allergy and Immunology

Kanokvalai Kulthanan, Papapit Tuchinda, Leena Chularojanamontri, Pattriya Chanyachailert, Wiwat Korkij, Amornsri Chunharas, Siriwan Wananukul, Wanida Limpongsanurak, Suwat Benjaponpitak, Wanee Wisuthsarewong, Kobkul Aunhachoke, Vesarat Wessagowit, Pantipa Chatchatee, Penpun Wattanakrai, Orathai Jirapongsananuruk, Jettanong Klaewsongkram, Nopadon Noppakun, Pakit Vichyanond, Puan Suthipinittharm, Kiat Ruxrungtham, Srisupalak Singalavanija, Jarungchit Ngamphaiboon
Urticaria is a common skin condition that can compromise quality of life and may affect individual performance at work or school. Remission is common in majority of patients with acute spontaneous urticaria (ASU); however, in chronic cases, less than 50% had remission. Angioedema either alone or with urticaria is associated with a much lower remission rate. Proper investigation and treatment is thus required. This guideline, a joint development of the Dermatological Society of Thailand, the Allergy, Asthma, and Immunology Association of Thailand and the Pediatric Dermatological Society of Thailand, is graded and recommended based on published evidence and expert opinion...
September 2016: Asian Pacific Journal of Allergy and Immunology
Kiat Ruxrungtham
No abstract text is available yet for this article.
September 2016: Asian Pacific Journal of Allergy and Immunology
Elizabeth Huiwen Tham, Alison Joanne Lee, Hugo Van Bever
Allergic diseases are on the rise in Asia. Aeroallergen exposure is a strong risk factor for sensitization, development and severity of atopic diseases, especially in the Asian paediatric population. Geographical and seasonal variations in aeroallergen sensitization are seen even within Asian countries and changes in aeroallergen sensitization patterns have been observed over time. Some possible reasons include climate change as well as rapid urbanization and improved sanitation which follow socioeconomic development...
September 2016: Asian Pacific Journal of Allergy and Immunology
Wiparat Manuyakorn, Prapasiri Singvijarn, Suwat Benjaponpitak, Wasu Kamchaisatian, Ticha Rerkpattanapipat, Cherapat Sasisakulporn, Wanlapa Jotikasthira
OBJECTIVE: Skin testing with penicilloyl-polylysine (PPL) and a minor determinant mixture (MDM) were previously recommended for evaluating β-lactam hypersensitivity. However, PPL and MDM have not been commercially available. This study was to determine the negative predictive value (NPV) of skin testing with β-lactam antibiotics for the diagnosis of β-lactam hypersensitivity. METHOD: Patients age 1-18 years old with a history of β-lactam hypersensitivity were evaluated by skin tests (a skin prick test, an intradermal test) with penicillin G, ampicillin, amoxicillin-clavulanic acid, and the suspect βlactam...
September 2016: Asian Pacific Journal of Allergy and Immunology
Fang Wang, Renxin Cai, Dingyang He, Yukun Zhao, Yanting Ye, Xingqi Zhang
BACKGROUND: The recruitment to the skin of drug-responsive T cells is responsible for the inflammatory profiles of non-immediate drug hypersensitivity reactions (niDHRs). Maculopapular exanthema (MPE) and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) have quite distinct T cell infiltrating patterns. OBJECTIVE: To investigate serum levels of CXCL9, CXCL10 and IFN-γ in patients with niDHRs, including MPE and SJS/TEN, to evaluate correlations between the cytokines, and to determine whether the inflammatory factors correlate with clinical severity in patients with SJS/TEN...
September 2016: Asian Pacific Journal of Allergy and Immunology
Nunthana Siripipattanamongkol, Pakit Vichyanond, Orathai Jirapongsananuruk, Jittima Veskitkul, Nualanong Visitsunthorn, Punchama Pacharn
BACKGROUND: The natural history of wheat allergy varies among different countries. OBJECTIVE: To study the age of resolution from IgE-mediated wheat allergy and to define the predictors of wheat tolerance. METHODS: Patients with a history of immediate reactions after wheat ingestion were enrolled. Skin prick test (SPT) and measurement of serum specific IgE (sIgE) to wheat and ω-5 gliadin were performed. Oral challenge to wheat was performed to determine wheat tolerance...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
Thanita Thammarakcharoen, Nattiya Hirankarn, Taninee Sahakitrungruang, Thanunrat Thongmee, Pavinee Kuptawintu, Sriprapai Kanoonthong, Voranush Chongsrisawat
BACKGROUND: Patients with type 1 diabetes mellitus (T1DM) have an increased risk for celiac disease (CD). Both diseases have a common genetic susceptibility locus in the human leukocyte antigen (HLA) class II alleles. Testing for tissue transglutaminase antibodies (anti-tTG) is highly accurate for CD diagnosis. OBJECTIVE: To determine the frequency of HLA-DQB1*0201/02and DQB1*0302 alleles and anti-tTG seropositivity in children with T1DM. METHODS: Forty-six children with T1DM (male:female=24:22; mean age 12±3...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
Sait Karaman, Semiha Erdem Bahçeci, Hikmet Tekin Nacaroğlu, Canan Şule Karaman, Demet Can
BACKGROUND: Oral food challenges (OFC) are performed for both diagnosis of food allergy and the food allergy is not supported by the history or because a newly developed tolerance needs to be established. OBJECTIVE: Our aims were to investigate the prevalence and severity of reactions during OFC in preschool children Material and Methods: A retrospective study was performed on children younger than 5 years in whom OFC was performed with milk, egg white and egg yolk, and who had been admitted to Behçet Uz Children Hospital, Division of Pediatric Allergy between the dates of January 1, 2010 and December 31, 2014...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
Loida Recopuerto Medina, Nat Malainual, John Donnie Ramos
BACKGROUND: Blo t 5, a major allergen from the house dust mite Blomia tropicalis had been identified as an important trigger of allergic diseases. Effects of sequence variations to the IgE binding activity of Blo t 5 remain unclear. OBJECTIVE: The study determined gene polymorphisms of Blo t 5, expressed the recombinant Blo t 5 allergen in E. coli system and determined its IgE reactivity in house dust mite allergic Filipino patients. METHOD: Gene polymorphism was determined using Polymerase Chain Reaction and DNA sequencing...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
Araya Satdhabudha, Kusumawadee Utispan, Paopaga Monthanapisut, Orapan Poachanukoon
OBJECTIVE: To evaluate the efficacy of positive pressure nasal irrigation and the incidence of bacterial colonization found in the irrigation device utilized for nasal saline irrigation in children with acute sinusitis. METHODS: We performed a randomized, prospective, controlled study of 80 children with acute sinusitis, aged 3-15 years. Each participant was randomized into one of two groups, one treated with a squeezable bottle and the other group treated with a syringe...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
Lira Yoon, Bo Ryung Kim, Young Mi Kim, Jaeyoung Lee, Kwanghoon Kim, Seong Heon Kim, Hye Young Kim
BACKGROUND: Prevalence of anaphylaxis is increasing steadly but we have little information of anaphylaxis. OBJECTIVE: This study was aimed to identify the prevalence of anaphylaxis and evaluate the cause and features of anaphylaxis according to age. METHODS: This study investigated gender, age, history of allergic diseases, causes and clinical symptoms, treatment and prognosis of anaphylaxis retrospectively in patients diagnosed with anaphylaxis in Pusan National University Hospital from January 2009 to June 2014...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
Liying Sun, Yanhua Xu, Yiwei Wang, Yueyan Lou, Yiping Xu, Yinshi Guo
BACKGROUND: The prevalence of allergic diseases has markedly increased in the last decades. It is therefore important to assess the distribution of airborne pollen, the most important aeroallergen, for allergic disease prevention and control. OBJECTIVE: To identify the species and quantity of airborne pollens, and observe their distribution characteristics in Shanghai, simultaneously using gravitational (Durham Sampler) and volumetric (Rotorod Sampler 40) methods...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
Oki Suwarsa, Sudigdo Adi, Ponpon Idjradinata, Endang Sutedja, Erda Avriyanti, Adlina Asfara, Hendra Gunawan
BACKGROUND: Staphylococcus aureus (S. aureus) triggers exacerbation of atopic dermatitis (AD) and causes chronic inflammation through the action of various proteins such as staphylococcal enterotoxin B (SEB). SEB has a role in activating interleukin (IL)-18, an important regulator of interferon (IFN)-γ and IL-4, in regards to a therapeutic strategy. OBJECTIVE: To determine the correlation of IL-18 level with the IL-4 and IFN-γ level in the lymphocyte cultures of AD patients with SEB stimulation...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
Ersoy Civelek, Mustafa Erkoçoğlu, Ayşegül Akan, Celal Özcan, Ayşenur Kaya, Emine Vezir, Tayfur Giniş, Müge Toyran, Mahmut Tokaç, Can Naci Kocabaş
BACKGROUND: Despite the increasing frequency of anaphylaxis, there is inadequate information on the etiology and clinical features in various countries, regions and age groups, especially in developing countries. OBJECTIVE: Our aim is to assess the etiology and clinical findings of anaphylaxis in Turkey. Gathering reliable data about the etiology and clinical findings of anaphylaxis in the general population will decrease the related morbidity and mortality. METHOD: We obtained the names and phone numbers of individuals who had been prescribed an epinephrine auto-injector with a diagnosis of anaphylaxis from ministry of health...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
Li Jiang, Don Changsom, Hatairat Lerdsamran, Wanibtisam Masamae, Anan Jongkaewwattana, Sopon Iamsirithaworn, Sineenat Oota, Suda Louisirirotchanakul, Prasert Auewarakul, Pilaipan Puthavathana
BACKGROUND: Avian influenza H5N1 and H7N9 viruses have jumped across species from avian to humans and become a threat to public health. Not much is known about pre-existing cross-reactive antibodies against these avian viruses in human population. OBJECTIVE: To determine the prevalence of cross-reactive anti-HA and anti-NA antibodies to avian influenza H5N1 and H7N9 viruses in Thai population. METHOD: Archival serum samples from 100 blood donors and 21 patients infected with 2009 pandemic influenza A (H1N1) (pdmH1N1) virus were investigated by hemagglutination-inhibition (HAI) and neuraminidase-inhibition (NAI) assays for anti-HA and anti-NA antibodies, respectively...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
Sunita Timalsena, Panwadee Pluangnooch, Adisak Wongkajornsilp, Kitipong Soontrapa
OBJECTIVE: Cytokine induced killer (CIK) cells are ex-vivo expanded T cells endowed with both T and Natural Killer cell properties. The standard protocol for generation of CIK cells is to culture peripheral blood mononuclear cells (PBMC) in the presence of interferon-gamma (IFN-γ), monoclonal antibody (mAb) against CD3 and interleukin-2 (IL-2). However, this protocol lacks costimulatory signal (CD28), crucial for T cell activation. Herein, the proliferation and functional properties of murine thymocytes derived CIK cells generated with or without costimulatory activation provided by anti-CD28 mAb were examined...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
Saori Uyeda, Tanjina Sharmin, Tomomitsu Satho, Keiichi Irie, Mineo Watanabe, Masato Hosokawa, Yukihiro Hiramatsu, Takayuki Koga, Yukihiko Nakashima, Nobuhiro Kashige, Akihisa Toda, Kenji Mishima, Fumio Miake
BACKGROUND: MF59, which is an adjuvant belonging to C30 member of the terpene family, is a T helper type-2 (Th2)-biased immune enhancer. Our previous studies showed that pyriproxyfen, a member of the terpene family with fewer carbon atoms (C20) than MF59, enhanced active T helper type-1 (Th1)-biased immune responses. OBJECTIVE: This study was performed to investigate the enhancement of antigen-specific immune responses by myrcene, a member of the terpene family with fewer carbon atoms (C10) than pyriproxyfen...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
Won Hee Seo, Byung Min Choi, Heechul Lee, Ji Tae Choung, Youngshin Han
BACKGROUND & OBJECTIVES: The environment of a pregnant woman can affect not only fetal growth and development, but also diseases in childhood. Neonatal cord blood cytokines are commonly used to evaluate the immune development of neonates. The purpose of this study was to evaluate the effects of the environment and diet during pregnancy on IL-4 and IFN-< in neonatal cord blood. METHOD: A total of 111 pregnant women participated in this study from April to November 2010...
June 30, 2016: Asian Pacific Journal of Allergy and Immunology
Thao Nguyen, Samantha Johnston, Anu Chacko, Damien Gibson, Julia Cepon, Peter Smith, Donald Staines, Sonya Marshall-Gradisnik
BACKGROUND: Mast cells (MCs) mediate inflammation through neuropeptides and cytokines, along with histamine and reactive oxygen species (ROS). Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is an illness characterized by an unexplained disabling fatigue with multiple physiological impairments as well as dysregulated cytokine profiles. OBJECTIVE: To determine mast cell phenotypes in isolated human PBMCs, in healthy controls and in CFS/ME patients. Second, determine receptor expression of RAGE and its ligand high mobility group box 1 protein (HMGB1)...
June 30, 2016: Asian Pacific Journal of Allergy and Immunology
Hyun Jin Min, Young Ho Hong, Hoon Shik Yang, Kyung Soo Kim
BACKGROUND: Eosinophil cationic protein (ECP) is present in eosinophil granules. It has been associated with eosinophil-associated disorders. OBJECTIVE: We compared serum ECP levels in allergic and non-allergic rhinitis patients and evaluated the association with the eosinophil count and the total IgE level. METHOD: We retrospectively reviewed medical records and categorized enrolled patients into the allergic (AR) and non-allergic rhinitis (NAR) groups...
June 30, 2016: Asian Pacific Journal of Allergy and Immunology
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