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Asian Pacific Journal of Allergy and Immunology

Pattarin Tangtanatakul, Siriwan Klinchanhom, Pimpayao Sodsai, Thitima Sutichet, Chutipha Promjeen, Yingyos Avihingsanon, Nattiya Hirankarn
BACKGROUND: The contents of exosomes determine their biological functions and represent a new class of epigenetic modulation of renal cells considering as novel class of biomarker. OBJECTIVE: Our study aims to investigate the expression of microRNAs (miRNA), including miR-10a/b, let-7a, and miR-21, in urinary exosomes isolated from patients with active lupus nephritis (LN) compared to inactive LN. METHODS: The exosomes were obtained from long-term follow up LN patients during active and 4 months after treatment (n = 3)...
August 13, 2018: Asian Pacific Journal of Allergy and Immunology
Patimaporn Wongprompitak, Nawarat Pleewan, Wiwit Tantibhedhyangkul, Angkana Chaiprasert, Pinnita Prabhasawat, Naharuthai Inthasin, Pattama Ekpo
BACKGROUND: Pythium insidiosum, a pathogenic oomycete, is a common causative organism of infectious corneal ulcer. Studying the innate immune response at the ocular surface is important for better understanding of the underlying pathogenesis and host defense against P. insidiosum infection. OBJECTIVE: The present study aims to investigate the role of Toll-like receptor (TLR)2 on human corneal epithelial cells (HCECs) in P. insidiosum infection. METHODS: Human embryonic kidney (HEK) cells were stimulated with either P...
August 13, 2018: Asian Pacific Journal of Allergy and Immunology
Naharuthai Inthasin, Patimaporn Wongprompitak, Chawikan Boonwong, Pattama Ekpo
BACKGROUND: Pathogenic Leptospira spp. is the causative agent of leptospirosis. Oral mucosal cavity is one of portal entry for this bacterium. Oral mucosal epithelium provides a physical barrier and secretes cytokines, chemokines and antimicrobial peptides (AMPs) in response to microbial infection. Human β-defensins (hBDs); hBD1, hBD2, and hBD3 are predominantly AMPs expressed in the oral cavity. Toll-like receptors (TLRs) have been reported in hBD regulation. TLR2 recognizes leptospiral lipopolysaccharide, and plays a key role in the early control of leptospirosis...
August 13, 2018: Asian Pacific Journal of Allergy and Immunology
Eun-Jung Jo, Seung-Eun Lee, Hye-Kyung Park
BACKGROUND: Autoimmune progesterone dermatitis is a rare disease characterized by eruption recurrence in the luteal phase of each menstrual cycle. As synthetic progesterones are increasingly used for assisted reproductive techniques (ARTs) for infertility or prevention of abortion, cases of dermatitis caused by exogenous progesterone have been reported. OBJECTIVE: To investigate the clinical characteristics of exogenous progestogen hypersensitivity (PH). METHODS: We retrospectively reviewed data from patients presenting with dermatitis induced by exogenous progesterone between 2011 and 2016...
August 13, 2018: Asian Pacific Journal of Allergy and Immunology
Mehmet Yasar Ozkars, Ozlem Keskin, Nazan Bayram, Mehmet Keskin, Hasan Bayram, Yavuz Sahin, Ercan Kucukosmanoglu, Nurhan Attila, Serkan Kirik Kirik
BACKGROUND: Hereditary angioedema (HAE) is characterised by recurrent episodes of angioedema and can be fatal. OBJECTIVE: The present study aimed to screen HAE. METHODS: A total of 60 individuals were screened. The frequency and severity of symptoms were scored from 0 to 8. Measurements were taken of C4 and C1 esterase inhibitor protein (C1-INH) levels. Mutation in the C1 inhibitor gene was examined in 9 patients with HAE. RESULTS: A positive correlation between the C1esterase inhibitor proteinlevels and C4 level was detected in the group as a whole (p < 0...
August 13, 2018: Asian Pacific Journal of Allergy and Immunology
Chaiyaphat Thaweerujirot, Tassalapa Daengsuwan
BACKGROUND: Wood's score, the assessment of childhood respiratory failure, has been used to assess childhood acute asthma severity in Thailand since 19th century. However, PRAM score, which is increasingly used in Western countries has not been evaluated among Thai children with asthma. OBJECTIVES: This study aims to determine whether Wood or PRAM score is better prediction of severity of childhood asthma exacerbation. METHODS: The prospective comparative study of severity asthma score was performed in asthmatic children, 2-18 years old, with acute asthma exacerbation at Queen Sirikit National Institute of Child Health...
August 13, 2018: Asian Pacific Journal of Allergy and Immunology
Chulamartd Wirapakorn, Uthaibhorn Singkham-In, Sujittra Taratummarat, Saowapha Surawut, Peerapat Visitchanakun, Tanittha Chatsuwan, Asada Leelahavanichkul
BACKGROUND: Ascorbate is a low-cost compound with a known bactericidal-synergy to antibitics. However, the synergy depends on concentrations and organisms. Thus, the synergy test by time-kill assay might be appropriate for the screening of the synergy. OBJECTIVE: We aimed to test the adjuvant property of ascorbate with ceftriaxone, a frequently prescribed β-lactam antibiotic. METHOD: Ascorbate was tested with several bacteria from the American Type Culture Collection (ATCC) including Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii and Escherichia coli for i) bactericidal property of ascorbate, alone or with ceftriaxone-combination, by time-kill assay, ii) an influence on the killing-activity of bone -marrow-derived macrophage and iii) the attenuation of myositis mouse model...
August 13, 2018: Asian Pacific Journal of Allergy and Immunology
Wannaporn Tongtako, Jettanong Klaewsongkram, Timothy D Mickleborough, Daroonwan Suksom
INTRODUCTION: Exercise training and vitamin C supplementation have both been recommended as an effective adjuvant treatment in the management of symptoms in patients with many diseases. However, its effects on rhinitis symptoms remain unclear. The aim of the present study was to determine the effects of exercise training alone, and in combination with vitamin C supplementation, on rhinitis symptoms in allergic rhinitis patients. METHODS: Twenty-seven rhinitis patients were randomized into 3 groups: control (CON; n = 8), exercise (EX; n = 9), and exercise combined with vitamin C (EX + Vit...
August 13, 2018: Asian Pacific Journal of Allergy and Immunology
Kanon Jatuworapruk, Lantarima Bhoopat, Punchong Hanvivadhanakul
OBJECTIVES: To describe the characteristics of patients with antiphospholipid syndrome (APS) in an Asian clinical practice setting. METHODS: We conducted a single-center, retrospective study of APS patients attending the rheumatology or hematology clinics, between January 2012 and December 2016. RESULTS: There were 450 patients suspected of having APS referred to our clinics. Seventy-four (16.4%) were diagnosed of APS, 51% of which were definite...
July 8, 2018: Asian Pacific Journal of Allergy and Immunology
Panadda Suwan, Phatcharee Praphaiphin, Pantipa Chatchatee
BACKGROUND: Caregivers often incorrectly use epinephrine autoinjectors. It is unclear whether this is due to insufficient training or a difficult-to-use tool. Furthermore, the high costs of epinephrine autoinjectors may limit their availability; so low-cost prefilled syringes may be the alternative. OBJECTIVES AND METHODS: We performed a prospective randomized trial to compare successful epinephrine administration at four stages: after reading written instructions, and immediately after, 6 weeks, and 3 months following video training...
July 8, 2018: Asian Pacific Journal of Allergy and Immunology
Ya Ru Yan, Yan Hua Xu, Qing Zheng, Yin Shi Guo
BACKGROUND: The worldwide prevalence of allergic diseases has increased during the last few decades, but it is not well known about the sensitization profiles of adult patients in Shanghai. OBJECTIVE: This study aimed to identify the prevalence and sex difference of allergen sensitization among adult with allergic diseases in Shanghai. METHODS: The sensitization profiles of 7,996 patients (18-60 yrs old) with allergic diseases at our center were retrospectively analyzed, based on the results of skin prick tests...
July 8, 2018: Asian Pacific Journal of Allergy and Immunology
Mastura Md Sani, Noor Suryani Mohd Ashari, Baharudin Abdullah, Kah Keng Wong, Kamarul Imran Musa, Rohimah Mohamud, Hern-Tze Tina Tan
BACKGROUND: Terminally differentiated effector memory (TEMRA) T cells exert potent effector function after activation. The proportions of CD4+ T cell subsets especially memory cells in allergic rhinitis (AR) patients sensitized to house dust mites (HDMs) have not been extensively studied. OBJECTIVE: This study aimed to compare the mean percentages and absolute counts of CD4+ memory T cell subsets between: (i) non-allergic controls and AR patients; (ii) mild AR patients and moderate-severe AR patients...
July 8, 2018: Asian Pacific Journal of Allergy and Immunology
Jaime S Rosa Duque, Patrick Cy Chong, Yu-Lung Lau, Marco Hk Ho
A seven-year-old girl developed angioedema and a generalized, erythematous rash several hours after receiving lignocaine with adrenaline reproducible on provocative challenge, confirming the first known case of generalized delayed-type hypersensitivity to local anaesthetics with cross-reactivity to bupivacaine but not chloroprocaine.
July 8, 2018: Asian Pacific Journal of Allergy and Immunology
Thao Nguyen, Donald Staines, Samantha Johnston, Sonya Marshall-Gradisnik
BACKGROUND: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is medically unexplained post-exertional fatigue associated with significant reduction in natural killer cell (NK) cytotoxicity activity. Cytotoxic activity relies on glycolytic flux and mitochondrial respiration to fulfill energetic cellular demands. While mitochondrial dysfunction has been reported in ME/CFS patients, no previous investigation has examined the bioenergetic profile of isolated NK cells from ME/CFS patients...
July 8, 2018: Asian Pacific Journal of Allergy and Immunology
Butsabong Lerkvaleekul, Soamarat Vilaiyuk
BACKGROUND: Interleukin (IL)-6 is the main proinflammatory cytokine in systemic juvenile idiopathic arthritis (SJIA). OBJECTIVE: To determine if serial changes in serum IL-6 levels can predict outcomes of SJIA patients. METHODS: This was a retrospective cohort study. Medical records of patients aged 2-19 years with active SJIA between January 2012 and February 2014 were reviewed. Baseline characteristics were recorded at enrollment. Serum IL-6 levels were measured at enrollment and at 2-4 weeks, 6-8 weeks, 3 months, and 6 months thereafter...
June 11, 2018: Asian Pacific Journal of Allergy and Immunology
Kumpol Amnuaypattanapon, Chitlada Limjindaporn, Winchana Srivilaithon, Ittabud Dasanadeba
INTRODUCTION: The characteristics and treatment outcomes of status asthmaticus patients in emergency department (ED) have not been described previously especially in Thailand. OBJECTIVE: To describe the characteristics, treatment outcomes and factors associated with status asthmaticus in Thai patients presenting to a single center ED. METHODS: A prospective observational study was performed at Thammasat University hospital, Thailand. The data collected included demographics, asthma history and control, previous ED attendances and hospital admissions, presenting clinical, laboratory and radiographic features, treatments given, and outcomes...
June 11, 2018: Asian Pacific Journal of Allergy and Immunology
Wansu Chen, Michael Schatz, Zhi Liang, Qiaowu Li, Ekaterina Sadikova, Zilu Zhang, Shalini Bagga, Robert S Zeiger
BACKGROUND: Little is known concerning the relative effectiveness of LTRAs compared to ICSs as monotherapy or LABA as add-on therapy in the Asian population. OBJECTIVES: In this retrospective cohort study, we examined the comparative effectiveness of montelukast to ICS as a first-line monotherapy and as an add-on in comparison with LABA on asthma exacerbations among Asian and non-Hispanic white persistent asthma patients in a large managed care organization. METHODS: The three add-on comparisons were montelukast plus low-dose ICS versus LABA plus low-dose ICS, montelukast plus low-dose ICS versus medium-dose ICS, and montelukast plus medium-dose ICS versus LABA plus medium-dose ICS...
June 11, 2018: Asian Pacific Journal of Allergy and Immunology
Hwanhee Park, Ji Young Lee, Ari Song, Minyoung Jung, Minji Kim, Insuk Sohn, MinJi Kim, Joongbum Cho, Kangmo Ahn, Jihyun Kim
BACKGROUND: Chronic urticaria (CU) has an adverse effect on academic achievement and psychosocial development in children. OBJECTIVE: We aimed to investigate the natural course of CU and to identify relevant factors associated with a poor CU prognosis in Korean children. METHODS: We retrospectively analyzed 253 children with episodes of wheals or angioedema at least 3 times a week that persisted for at least 6 weeks. Clinical data and laboratory results were obtained from medical records and parental telephone interviews...
June 11, 2018: Asian Pacific Journal of Allergy and Immunology
Torpong Thongngarm, Adhiratha Boonyasiri, Panitan Pradubpongsa, Nattaporn Tesavibul, Tauangtham Anekpuritanang, Piyawut Kreetapirom, Mongkhon Sompornrattanaphan
BACKGROUND: Good syndrome (GS) is an adult-onset immunodeficiency characterized by coexisting thymoma and hypogammaglobulinemia. Clinical course after treatment with intravenous immunoglobulin (IVIg) has rarely been reported. OBJECTIVE: To investigate and report the clinical course and outcomes of GS patients after treatment with IVIg at Thailand's largest national tertiary referral hospital METHODS: This retrospective chart review included patients diagnosed with GS and treated with IVIg during the 1 January 2005 to 31 December 2015 study period...
June 11, 2018: Asian Pacific Journal of Allergy and Immunology
Yukihiro Hiramatsu, Daisuke Sakamoto, Tomomitsu Satho, Keiichi Irie, Fumio Miake, Minoru Maeda, Nobuhiro Kashige
BACKGROUND: Lactobacilli show anti-inflammatory effects in the human intestine, and their genomic DNA was identified as one of the anti-inflammatory components. Increased levels of the natural protease inhibitor elafin in the intestine plays an important role in protection against intestinal inflammation. However, there have been no previous reports regarding whether lactobacilli increase elafin levels. OBJECTIVE: This study was performed to investigate whether Lactobacillus plantarum induces elafin secretion from the human epithelial colorectal adenocarcinoma cell line, Caco-2...
June 11, 2018: Asian Pacific Journal of Allergy and Immunology
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