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Asian Pacific Journal of Allergy and Immunology

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https://www.readbyqxmd.com/read/28802032/deciphering-critical-amino-acid-residues-to-modify-and-enhance-the-binding-affinity-of-ankyrin-scaffold-specific-to-capsid-protein-of-human-immunodeficiency-virus-type-1
#1
Somphot Saoin, Tanchanok Wisitponchai, Kannaporn Intachai, Koollawat Chupradit, Sutpirat Moonmuang, Sawitree Nangola, Kuntida Kitidee, Kanda Fanhchaksai, Vannajan Sanghiran Lee, Saw-See Hong, Pierre Boulanger, Phimonphan Chuankhayan, Chun-Jung Chen, Chatchai Tayapiwatana
BACKGROUND: AnkGAG1D4 is an artificial ankyrin repeat protein which recognizes the capsid protein (CA) of the human immunodeficiency virus type 1 (HIV-1) and exhibits the intracellular antiviral activity on the viral assembly process. Improving the binding affinity of AnkGAG1D4 would potentially enhance the AnkGAG1D4-mediated antiviral activity. OBJECTIVE: To augment the affinity of AnkGAG1D4 scaffold towards its CA target, through computational predictions and experimental designs...
August 8, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28802031/quality-of-life-among-caregivers-and-growth-in-children-with-parent-reported-food-allergy
#2
Tanya Kajornrattana, Pasuree Sangsupawanich, Araya Yuenyongviwat
BACKGROUND: Some caregivers who believe their children have food allergy avoid feeding certain foods to their children without proper allergy tests. Such actions made without a proper diagnosis can negatively impact the child's health and impose an unnecessary burden on the caregivers. OBJECTIVE: This study aimed to evaluate the caregiver quality of life (QoL) and growth in children with a parent-reported food allergy. METHODS: An observational cross-sectional study was performed in 200 children younger than five years who had a parent-reported food allergy...
August 8, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28802030/solenopsis-geminata-tropical-fire-ant-anaphylaxis-among-thai-patients-its-allergens-and-specific-ige-reactivity
#3
Rutcharin Potiwat, Sasipa Tanyaratsrisakul, Santi Maneewatchararangsri, Wiparat Manuyakorn, Ticha Rerkpattanapipat, Yudthana Samung, Chukiat Sirivichayakul, Wanpen Chaicumpa, Raweerat Sitcharungsi
BACKGROUND: Specific IgE against Solenopsis invicta (imported fire ant) remains the current diagnostic tool for allergy to ants worldwide. However, S. invicta may not be the only cause of ant anaphylaxis in Thai patients. OBJECTIVE: To characterize ant species causing anaphylaxis in Thai patients and to test allergenic reactivity to whole body extracts (WBE) of S. geminata (tropical fire ants) in patients with evidence of IgE-mediated ant anaphylaxis. METHODS: Thirty-two patients with ant anaphylaxis were identified...
August 8, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28802029/immediate-hypersensitivity-reaction-to-ketamine-in-children-with-history-of-atopic-disease
#4
Seunghee Ki, Sehun Lim, Myoung-Hun Kim, Younghan Kim
Many investigators have demonstrated that a large number of patients who experience anaphylaxis during anesthesia have a history of atopic disease or allergy to a specific substance. Here, we review a hypersensitivity reaction to ketamine in a nine-year-old child with a history of atopic disease.
August 8, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28802028/h5n1-ns-genomic-segment-distinctly-governs-the-influenza-virus-infectivity-and-cytokine-induction-in-monocytic-cells
#5
Prem Prasad Lamichhane, Kobporn Boonnak, Don Changsom, Pirom Noisumdaeng, Kantima Sangsiriwut, Sa-Nga Pattanakitsakul, Pilaipan Puthavathana
BACKGROUND: The level of virulence of H5N1 highly pathogenic avian influenza (HPAI) virus was higher than those of the other virus subtypes. It has been suggested that the nonstructural (NS) gene might be a factor contributing to H5N1 HPAI virulence. OBJECTIVES: To determine the efficiency of the NS genomic segment of H5N1 HPAI virus on governing viral infectivity and cytokine induction in monocytic cells compared to other virus strain/subtypes. METHODS: By reverse genetics, five reassortant influenza viruses carrying the NS genomic segment derived from seasonal influenza A(H1N1), 2009 pandemic A(H1N1), A(H3N2) or H5N1 HPAI virus in the backbone of A/Puerto Rico/8/34 H1N1 (PR8) virus were constructed together with the reassorted PR8 virus control, i...
August 8, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28802027/performance-evaluation-of-the-bioneer-accupower%C3%A2-hiv-1-quantitative-rt-pcr-kit-comparison-with-the-roche-cobas%C3%A2-ampliprep-cobas-taqman%C3%A2-hiv-1-test-ver-2-0-for-quantification-of-hiv-1-viral-load-in-indonesia
#6
Agus Susanto Kosasih, Christine Sugiarto, Hubertus Hosti Hayuanta, Runingsih Juhaendi, Lyana Setiawan
BACKGROUND: Measurement of viral load in human immunodeficiency virus type 1 (HIV-1) infected patients is essential for the establishment of a therapeutic strategy. Several assays based on qPCR are available for the measurement of viral load; they differ in sample volume, technology applied, target gene, sensitivity and dynamic range. The Bioneer AccuPower® HIV-1 Quantitative RT-PCR is a novel commercial kit that has not been evaluated for its performance. OBJECTIVE: This study aimed to evaluate the performance of the Bioneer AccuPower® HIV-1 Quantitative RT-PCR kit...
August 8, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28802026/reversible-immune-abnormality-and-regulatory-t-cells-in-offspring-of-der-p-1-exposed-female-mice
#7
Lu Tan, Zezhang Tao, Yonggang Kong, Yu Xu
BACKGROUND: Maternal allergic diseases have an important influence on the origin of allergic rhinitis (AR) in offspring, but the mechanism and the duration of the maternal effect are unknown. Previous researches prompted the important roles of Tregs and Foxp3 DNA methylation in the development of allergic diseases. OBJECTIVE: To investigate the immune state and Tregs in the offspring of Der p 1-exposed female mice. METHOD: BALB/c female mice were exposed to Der p1 to construct the mouse AR model, then mated with normal male mice...
August 8, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28577524/childhood-asthma-control-in-japan-a-nationwide-cross-sectional-web-based-survey
#8
Koichi Yoshida, Mari Sasaki, Yuichi Adachi, Toshiko Itazawa, Hiroshi Odajima, Hirohisa Saito, Akira Akasawa
BACKGROUND: Recent surveys have shown that many patients with asthma experience uncontrolled symptoms and decreased quality of life due to their disease. However, few large population-based studies have evaluated asthma control in Japanese children. OBJECTIVE: To show the reality of asthma control and the pattern of asthma controller medication use among Japanese children. METHODS: In 2012, a web-based survey was conducted to identify children aged 6 to 11 years with asthma in Japan...
June 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28577523/quantification-of-fel-d-1-in-house-dust-samples-of-cat-allergic-patients-by-using-monoclonal-antibody-specific-to-a-novel-ige-binding-epitope
#9
Natt Tasaniyananda, Anchalee Tungtrongchitr, Watee Seesuay, Yuwaporn Sakolvaree, Pisinee Aiumurai, Nitaya Indrawattana, Wanpen Chaicumpa, Nitat Sookrung
BACKGROUND: Avoidance of allergen exposure is an effective measure for preventing naÏve and allergic individuals from sensitization (primary intervention) and disease aggravation (secondary intervention), respectively. Regular monitoring of the allergens in the environment is required for the effective intervention. Thus, there is a need for cost-effective test kits for environmental allergen quantifications. OBJECTIVE: To invent a test kit for quantification of cat major allergen, Fel d 1...
June 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28577522/rosai-dorfman-disease-with-features-of-igg4-related-disease-in-the-breast-cases-report-and-literature-review
#10
Mei Liu, Xiru Li, Ying Li, Zhuo Wang, Liuquan Cheng, Xin Song, Yun Wu
BACKGROUND: A proportion of cases of Rosai-Dorfman disease exhibit some histological features consistent with IgG4-related disease (IgG4RD). Several investigators have discussed whether Rosai-Dorfman disease belongs to the spectrum of IgG4RD or is concurrent with it by coincidence. OBJECTIVE: To elucidate the relationship between the two diseases, we report key features, including IgG4 and amyloid levels, of four cases of Rosai-Dorfman disease in the breast. METHODS: The histological features of the four cases were analyzed and the numbers of IgG4+ plasma cells and IgG4/IgG ratios were evaluated...
June 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28577521/seven-chronic-granulomatous-disease-cases-in-a-single-center-experience-and-a-review-of-the-literature
#11
Şeyhan Kutluğ, Gülnar Şensoy, Asuman Birinci, Berkay Saraymen, Mustafa Yavuz Köker, Alişan YΙldΙran
BACKGROUND: Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused by defects in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme system. This disease causes the disordered functioning of phagocytic cells. It is characterized by life-threatening and/or recurrent infections by bacteria and fungi. CGD has one X-linked recessive subtype (X-CGD) and four autosomal recessive subtypes (AR-CGD), and the differential diagnosis is important in such chronic inflammatory disorders...
June 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28577520/duration-of-neutralizing-antibody-persisting-in-thai-individuals-after-childhood-vaccination-against-smallpox
#12
Kannikar Kwanchum, Silawun Ampol, Anchalee Thongput, Navin Horthongkham, Suthiphol Udomphunthurak, Sontana Siritantikorn, Wannee Kantakamalakul
BACKGROUND: Although smallpox was completely eliminated by 1980, it remains possible that variola virus could be intentionally released in an act of bioterrorism. Thus, several studies have been performed to detect antibody levels after smallpox vaccination of the current population in various countries to indicate the duration of maintenance of immunological memory. Our study endeavored to investigate the level of neutralizing (Nt) antibody responses of Thai individuals who had been immunized with smallpox vaccine during childhood...
June 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28577519/drug-allergy-evaluation-for-betalactam-hypersensitivity-cross-reactivity-with-cephalosporines-carbapenems-and-negative-predictive-value
#13
Mona Al-Ahmad, Tito Rodriguez-Bouza
BACKGROUND: There are no studies on cross-reactivity of betalactams among patients allergic to penicillin, or on the negative predictive value (NPV) of penicillin allergy evaluation from Arabian Gulf countries OBJECTIVE: We aimed to assess the role and NPV of drug provocation test (DPT) for betalactam hypersensitivity reactions in patients referred for allergy evaluation in Kuwait METHODS: Skin test (ST) was performed for all patients with a history of betalactam hypersensitivity, other than anaphylaxis...
June 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28364412/the-validation-and-evaluation-of-anti-hiv-testing-algorithm-used-in-mobile-clinic-setting-for-men-who-have-sex-with-men-in-metropolitan-bangkok-thailand
#14
Tippawan Pankam, Sarun Saensiriphan, Suphackok Areeyolwattana, Napapat Barisri, Supabhorn Pengnonyang, Sunee Sirivichayakul, Nittaya Phanuphak, Praphan Phanuphak
BACKGROUND: Same-day anti-HIV testing algorithm is recommended by Thai National Guidelines. We compared performance characteristics of algorithms used in a mobile clinic and a facility-based clinic for men who have sex with men (MSM) in Bangkok. METHODS: Mobile clinic samples collected from 4 saunas and 2 spa venues were tested by Alere DetermineTM HIV 1/2, followed by DoubleCheck GoldTM Ultra HIV 1/2 and SD Bioline HIV 1/2 3.0. All samples were re-tested at the Thai Red Cross Anonymous Clinic (TRCAC) by Architect HIV Ag/Ab or Elecsys HIV combi PT, followed by Alere DetermineTM HIV 1/2 and Serodia HIV 1/2...
April 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28364411/urinary-cysteinyl-leukotriene-e4-level-and-therapeutic-response-to-montelukast-in-children-with-mild-obstructive-sleep-apnea
#15
Kanokkarn Sunkonkit, Suchada Sritippayawan, Montida Veeravikrom, Jitladda Deerojanawong, Nuanchan Prapphal
BACKGROUND: Antileukotriene has been used for alleviating disease severity in children with adenotonsillar hypertrophy (ATH) and mild obstructive sleep apnea (OSA). Previous study showed the relationship between urinary cysteinyl leukotriene E₄ (uLTE₄) level and therapeutic response to montelukast in asthmatic adults. However, this relationship has never been investigated in pediatric OSA. OBJECTIVES: To determine the relationship between uLTE₄ level and therapeutic response to montelukast in children with ATH and mild OSA...
April 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28364410/association-analyses-identify-two-susceptibility-loci-5q31-and-5q22-1-for-atopic-dermatitis-in-chinese-han-population
#16
Xiao-Yun Jiang, Jin-Hua Zhao, Chong-Xian Yu, Ling Fang, Xiao-Dong Zheng, Xian-Yong Yin, Yan-Yan Wu, Xian-Fa Tang, Fu-Sheng Zhou, Xue-Jun Zhang, Feng-Li Xiao
BACKGROUND: Atopic dermatitis (AD) and other atopic diseases often share some common genetic and pathogenic bases. Recent genome-wide association studies (GWAS) have identified several loci associated with atopic diseases, allergic sensitization and asthma in different populations. The aim of this study was to investigate whether these susceptibility loci were related to AD in Chinese Han population. METHODS: Eight single nucleotide polymorphisms (SNPs) from recent atopic diseases and allergic sensitization GWAS were genotyped in 3,013 AD patients and 5,483 healthy controls in Chinese Han population using Sequenom MassArray system...
April 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28364409/metabolomics-analysis-of-anaphylactoid-reaction-reveals-its-mechanism-in-a-rat-model
#17
Yubin Xu, Na Guo, Deqiang Dou, Xiaoku Ran, Chunyan Liu
BACKGROUND: Anaphylactoid reactions, accounting for more than 77% of all immune-mediated immediate hypersensitivity reactions, have become a serious threat to public health, but their effect mechanism is not clear and diagnostic tests are limited. Comprehensive metabolite analysis may reveal the anaphylactoid effect mechanism systematically and provide reference for future diagnostic purposes. METHODS: Plasma from Brown Norway rats given intravenous injection of saline, compound 48/80 (2...
April 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28364408/comparison-of-the-efficacy-and-safety-of-pollen-allergen-extracts-using-skin-prick-testing-and-serum-specific-ige-as-references
#18
Nualanong Visitsunthorn, Kittipos Visitsunthorn, Punchama Pacharn, Orathai Jirapongsananuruk, Chaweewan Bunnag
BACKGROUND: Allergen extracts may be different due to the difference in dissemination of allergen-containing species in various geographical areas. Therefore, we wish to develop our own extracts to ensure the precision and quality of diagnosis. OBJECTIVES: To compare the efficacy and safety of our locally prepared pollen allergen extracts to imported ones, using skin prick testing (SPT) and serum specific IgE (sIgE) as references. METHODS: This prospective, randomized, double-blinded, self-controlled study was performed in respiratory allergic adult volunteers who are sensitized to at least one kind of pollen...
April 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28364407/mosquito-allergy-in-children-clinical-features-and-limitation-of-commercially-available-diagnostic-tests
#19
Wiparat Manuyakorn, Sulak Itsaradisaikul, Suwat Benjaponpitak, Wasu Kamchaisatian, Cherapat Sasisakulporn, Wanlapa Jotikasthira, Ponpan Matangkasombut
OBJECTIVE: To determine the clinical features of mosquito allergy in children and the ability of commercially available mosquito allergy tests to detect children with mosquito allergy in Thailand. METHODS: Patients with mosquito allergy aged 1 month to 18 years were recruited. Demographic data, history of mosquito allergy (onset of the reaction, reaction type) and clinical features were recorded. A skin prick test using a commercially available whole body allergen extract from Culex pipiens was performed, and serum was tested for specific IgE antibodies to Aedes communis whole body extract...
April 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28364406/component-resolved-diagnostics-in-thai-children-with-cow-s-milk-and-egg-allergy
#20
Wipa Jessadapakorn, Pasuree Sangsupawanich, Natthakul Wootipoom, Oranart Suddeaugrai, Araya Yuenyongviwat
BACKGROUND AND OBJECTIVE: Component-resolved diagnostics (CRD) have garnered a lot of attention in recent years in the diagnosis of food allergies. We aimed to investigate sensitization against cow's milk and egg white components, and to study the clinical usefulness of serum food-specific immunoglobulin E (sIgE) to cow's milk and egg white components in Thai children with cow's milk and egg allergies. METHOD: Children with IgE-mediated cow's milk and/or egg allergy were enrolled...
April 1, 2017: Asian Pacific Journal of Allergy and Immunology
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