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International Journal of Developmental Neuroscience

Marwa Ben Jdila, Chahnez Triki, Bochra Ben Rhouma, Rihab Ben Jomaa, Abir Ben Issa, Leila Ammar-Keskes, Fatma Kamoun, Faiza Fakhfakh
INTRODUCTION: West Syndrome is a severe epileptic encephalopathy characterized by epileptic spasms, hypsarrhythmia, and regression of psychomotor acquisitions beginning in the first year of life. ARX and CDKL5 genes were identified as linked to the most frequent genetic causes of West Syndrome. METHODS: The present study reports the clinical, molecular and bioinformatic investigation of the patient with severe West syndrome. RESULTS: Molecular analysis of the two candidate genes, i...
September 17, 2018: International Journal of Developmental Neuroscience
Pauline Maciel August, Rafael Moura Maurmann, André Brum Saccomori, Mariana Crestani Scortegagna, Eduardo Borges Flores, Caroline Peres Klein, Bernardo Gindri Dos Santos, Vinicius Stone, Bárbara Mariño Dal Magro, Leo Cristhian, Carolina Nunes Santo, Régis Hözer, Cristiane Matté
Prenatal and early postnatal environments can permanently influence health throughout life. Early overnutrition increases the risk to develop chronic diseases. Conversely, the intake of flavonoids and exercise practice during pregnancy seem to promote long-term benefits to offspring. We hypothesized that benefic interventions during pregnancy could protect against possible postnatal neurochemical alterations caused by overnutrition induced by reduced litter size. Female Wistar rats were divided into four groups: (1) sedentary + vehicle, (2) sedentary + naringenin, (3) swimming exercise + vehicle, and (4) swimming exercise + naringenin...
September 16, 2018: International Journal of Developmental Neuroscience
Rui Yang, Shao Liu, Yi Zheng, Mengqi Zhang, Ruili Dang, Mimi Tang
BACKGROUND: Polyunsaturated fatty acids (PUFAs) are normal components of growth and development and its derivatives especially n-3 PUFAs have an influence on the development and maturation of nervous system. The purpose of our present study was to investigate the effect of maternal n-3 PUFAs dietary on physical maturation and the neurobiological development of the rat offspring. METHODS: According to the content of n-3 PUFAs in their diets, female dams were randomly divided into three treatment groups (n = 6-7): deficiency, control and supplementation...
September 14, 2018: International Journal of Developmental Neuroscience
Min Liu, Yuhuan Wang, Sijia Yang, He Wei, Miao Tuo, Fei Chang, Yuhui Wang
OBJECTIVE: To identify candidate genes for the clinical diagnosis of floppy infant syndrome (FIS) using single nucleotide polymorphism (SNP) array in a specific FIS family. METHODS: SNP array analysis of the whole chromosome copy number was performed in the proband (III1 ). Multiple polymerase chain reaction (PCR) combined with denaturing high-performance liquid chromatography (DHPLC) was used to validate the array data. RESULTS: A large 5...
September 11, 2018: International Journal of Developmental Neuroscience
Yuanpei Zhang, Hongxuan Wang, Yi Li, Ying Peng
INTRODUCTION: Fetal alcohol spectrum disorder is caused by maternal ethanol exposure; it causes physical, behavioral, cognitive, and neural impairments (Murawski et al., 2015). Mechanisms of FASD causing damage are not yet fully elucidated. Oxidative stress might be one of its mechanisms (Henderson et al., 1995). Yet no effective treatment against FASD has been found other than ethanol abstention (Long et al., 2010). METHODS: This review summarizes relevant literatures regarding interventions targeting oxidative stress that may relieve fetal alcohol spectrum disorder...
September 8, 2018: International Journal of Developmental Neuroscience
Shuji Iritani, Youta Torii, Chikako Habuchi, Hirotaka Sekiguchi, Hiroshige Fujishiro, Mari Yoshida, Yasuhiro Go, Astushi Iriki, Masaki Isoda, Norio Ozaki
The precise biological etiology of autism spectrum disorder (ASD) remains unknown. In this study, we investigated the neuropathology of a monkey model of autism Human ABCA13 is the largest ABC transporter protein, with a length of 5058 amino acids and a predicted molecular weight of >450 kDa. However, the function of this protein remains to be elucidated. This protein is thought to be associated with major psychiatric disease. Using this monkey model of autism with an ABCA13 deletion and a mutation of 5HT2c, we neuropathologically investigated the changes in the neuronal formation in the frontal cortex...
September 7, 2018: International Journal of Developmental Neuroscience
Caroline Peres Klein, Karoline Dos Santos Rodrigues, Régis Mateus Hözer, Natividade de Sá Couto-Pereira, André Brum Saccomori, Bárbara Mariño Dal Magro, Mariana Scortegagna Crestani, Juliana Bender Hoppe, Christianne Gazzana Salbego, Carla Dalmaz, Cristiane Matté
Several environmental factors affect child development, such as the intrauterine environment during the embryonic and fetal development and early postnatal environment provided by maternal behavior. Although mechanistic effects of maternal exercise on offspring health improvement are not yet completely understood, the number of reports published demonstrating the positive influence of maternal exercise have increase. Herein, we addressed issues related to early postnatal environment provided by maternal behavior and early developmental physical landmarks, sensorimotor reflexes, and motor movements ontogeny...
August 30, 2018: International Journal of Developmental Neuroscience
Alex M Pagnozzi, Eugenia Conti, Sara Calderoni, Jurgen Fripp, Stephen E Rose
Autism Spectrum Disorder (ASD) affects approximately 1% of the population and leads to impairments in social interaction, communication and restricted, repetitive behaviours. Establishing robust neuroimaging biomarkers of ASD using structural magnetic resonance imaging (MRI) is an important step for diagnosing and tailoring treatment, particularly early in life when interventions can have the greatest effect. However currently, there is mixed findings on the structural brain changes associated with autism. Therefore in this systematic review, recent (post-2007), high-resolution (3 T) MRI studies investigating brain morphology associated with ASD have been collated to identify robust neuroimaging biomarkers of ASD...
August 30, 2018: International Journal of Developmental Neuroscience
Cassiana Siebert, Carolina Gessinger Bertó, Fernanda Silva Ferreira, Daniella de S Moreira, Tiago Marcon Dos Santos, Angela T S Wyse
The aim of this study was to verify the effects of ovariectomy (OVX) and/or vitamin D supplementation (VIT D) on inflammatory and cholinergic parameters in hippocampus, as well as on serum estradiol and VIT D levels of rats. Ninety-day-old female Wistar rats were randomly divided into four groups: SHAM, OVX, VIT D or OVX + VIT D. Thirty days after OVX, VIT D (500 IU/kg/day) was supplemented by gavage, for 30 days. Approximately 12 h after the last VIT D administration, rats were euthanized and hippocampus and serum were obtained for further analyses...
August 30, 2018: International Journal of Developmental Neuroscience
María Eugenia Bogetti, Victorio M Pozo Devoto, Melina Rapacioli, Vladimir Flores, Sara Fiszer de Plazas
A decrease in the concentration of oxygen in the blood and tissues (hypoxia) produces important, sometimes irreversible, damages in the central nervous system (CNS) both during development and also postnatally. The present work aims at analyzing the expression of nerve growth factor (NGF) and p75 and the activation of TrkA in response to an acute normobaric hypoxic event and to evaluate the possible protective role of exogenous NGF. The developing chick optic tectum (OT), a recognized model of corticogenesis, was used as experimental system by means of in vivo and in vitro studies...
August 27, 2018: International Journal of Developmental Neuroscience
Rupali Sharma, Jasmine Rooke, Daria Kolmogorova, Brett Melanson, Jean-François Mallet, Chantal Matar, Jaclyn Schwarz, Nafissa Ismail
Puberty is a critical developmental period that is characterized by significant brain development. Exposure to stress during this time can alter brain functioning setting the stage for long-lasting behavioural outcomes. The objective of this study was to investigate age and sex differences in the peripheral and central immune responses, along with sickness behaviour, following immune stress. The results showed that LPS treatment increased serum cytokine levels and sickness symptoms in all mice. Pubertal males displayed increased IL-1β concentrations at 2 h and increased IL-6 concentrations at 8 h post-treatment whereas increased concentrations of TNFα, IL-10, IL-12, IL-1β, IFNγ, and IL-6 persisted at 8 and 24 h in adult females...
August 27, 2018: International Journal of Developmental Neuroscience
Vicki Bitsika, Christopher F Sharpley, Mary E McMillan, Linda L Agnew
Children with Autism Spectrum Disorder (ASD) show dysregulation of the expected Hypothalamus-Pituitary-Adrenal (HPA) axis and elevated cortisol responses to stress and response patterns, but little has been reported regarding their recovery from stress in terms of cortisol concentrations. This response was investigated in a sample of 32 young males with ASD aged between 9 and 18 years (M = 14.3 yr, SD = 2.7 yr), using a standardised experimental protocol combined with individualised stressor and non-stressor tasks...
August 27, 2018: International Journal of Developmental Neuroscience
Chingju Lin, Pei-Yi Chen, Hsu-Chin Chan, Yi-Ping Huang, Nai Wen Chang
Activation of peroxisome proliferator-activated receptor alpha (PPARα) has been reported to modulate cell proliferation, migration, and differentiation in astrocytes. In this study, we used a retinoic acid (RA)-induced differentiation model of NTERA-2/clone D1 (NT2) cells to explore the functional significance of PPARα in neuronal differentiation. We found that activating PPARα by Wy14643 accelerated neuronal differentiation via regulating the expression of neuronal markers. RT-PCR assays showed a significant increase in NeuroD expression and a decrease in nestin expression in cells treated concomitantly with RA and Wy14643 for 2 days compared to the levels in cells treated with RA alone...
August 26, 2018: International Journal of Developmental Neuroscience
Lorena Rubio, Laura Téllez, Mirelta Regalado, Carmen Torrero, Manuel Salas
Nutrition plays a fundamental role in learning and memory, and early experimental undernutrition interferes with brain memory processes. Social transmission of food preference (STFP) is a natural olfactory paired-associate learning test that has not been used to assess the effects of early undernutrition on memory consolidation. Male Wistar rats were randomly divided into two groups: control and early undernourished. The underfed rats received different percentages of a balanced diet during gestation. After birth, pups were underfed by alternating every 12 h between two lactating dams, one with ligated nipples...
August 24, 2018: International Journal of Developmental Neuroscience
Yiliyasi Mayila, Toshiya Matsuzaki, Takeshi Iwasa, Altankhuu Tungalagsuvd, Munksaihan Munkhzaya, Kiyohito Yano, Rie Yanagihara, Takako Tokui, Takeshi Kato, Akira Kuwahara, Minoru Irahara
PURPOSE: It is known that various types of stress in early life increase the incidence of diabetes, myocardial infarctions, and psychiatric disorders in adulthood. We examined the mechanism by which neonatal immune stress reduces sexual behavior in adult male rats METHODS: Male rats were randomly divided into 3 groups: the control (n = 17), post-natal day 10 lipopolysaccharide (PND10LPS) (n = 31), and PND25LPS (n = 16) groups, which received intraperitoneal injections of LPS (100 μg/kg) or saline (injection volume: ≤0...
August 18, 2018: International Journal of Developmental Neuroscience
Jacob Levman, Lana Vasung, Patrick MacDonald, Sean Rowley, Natalie Stewart, Ashley Lim, Bryan Ewenson, Albert Galaburda, Emi Takahashi
Autism is a group of complex neurodevelopmental disorders characterized by impaired social interaction, restricted and repetitive behavior. We performed a large-scale retrospective analysis of 1,996 structural magnetic resonance imaging (MRI) examinations of the brain from 1,769 autistic and neurologically typically developing patients (aged 0-32 years), and extracted regional volumetric measurements distributed across 463 brain regions of each patient. The youngest autistic patients (<2.5 years) were diagnosed after imaging and identified retrospectively...
August 12, 2018: International Journal of Developmental Neuroscience
Shruti Jawale, Sadhana Joshi, Anvita Kale
Cognitive development may be influenced by maternal nutrition especially fats. Indian population is vegetarian and main source of fat is dairy. This study investigates the effect of dairy fat consumption during pregnancy in an animal model on fatty acids, brain neurotrophins (brain derived neurotrophic factor: BDNF; and nerve growth factor: NGF) and cognitive performance in adult offspring. Pregnant Wistar rats were assigned to control (Control C) and four treatment groups: High fat diet (HFD); High fat diet supplemented with omega-3 fatty acids (HFDO); High fat diet deficient in vitamin B12 ( HFBD); High fat deficient in vitamin B12 supplemented with omega-3 fatty acids (HFBDO)...
August 12, 2018: International Journal of Developmental Neuroscience
Sima DastAmooz, Shahzad Tahmasebi Boroujeni, Mehdi Shahbazi, Yasamin Vali
The popularity of using wireless fidelity over the last decades increased apprehensions about impact of high frequency electromagnetic fields (EMF) on health. Most of previous studies mentioned adverse effect of EMF on cognitive processes, but so far, no study has provided a way to control adverse effects of EMF exposure. The purpose of this study was to examine the effect of Wi-Fi EMF and physical activity on spatial learning and motor function in pregnant rat's offspring. Forty Albino-Wistar pregnant rats divided randomly into four groups (EMF, physical activity, combined 2...
August 1, 2018: International Journal of Developmental Neuroscience
Maria Pia Bucci, Nathalie Goulème, Delphine Dehouck, Coline Stordeur, Eric Acquaviva, Mathilde Septier, Aline Lefebvre, Christophe-Loïc Gerard, Hugo Peyre, Richard Delorme
In everyday life, our activities frequently involve the simultaneous performance of two or more tasks. Sharing attention between two concurrent tasks may result in a decrease in performance specifically among children with neurodevelopmental disorders. The objective of the study was to determine whether the influence of postural conditions (sitting condition, single task; standing condition, dual task) on eye movement performances on three visual tasks with high attentional load (visually-guided saccade task, memory-guided saccade task and fixation task) was different in children with neurodevelopmental disorders (attention deficit and hyperactive disorder, dyslexia, and high functioning autism spectrum disorder) when compared to typically developing children...
July 26, 2018: International Journal of Developmental Neuroscience
Grace Violeta Espinoza Pardo, Aldo Bolten Lucion, Maria Elisa Calcagnotto
The morphological and functional development of inhibitory circuit in the anterior piriform cortex (aPC) during the first three postnatal weeks may be crucial for the development of odor preference learning in infant rodents. As first step toward testing this hypothesis, we examined the normal development of GABAergic synaptic transmission in the aPC of rat pups during the postnatal days (P) 5-8 and 14-17. Whole cell patch-clamp recordings of layer 2/3 (L2/3) aPC pyramidal cells revealed a significant increase in spontaneous (sIPSC) and miniature (mIPSC) inhibitory postsynaptic current frequencies and a decrease in mIPSC rise and decay-time constant at P14-P17...
July 25, 2018: International Journal of Developmental Neuroscience
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