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International Journal of Developmental Neuroscience

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https://www.readbyqxmd.com/read/28778811/adolescent-escitalopram-prevents-the-effects-of-maternal-separation-on-depression-and-anxiety-like-behaviours-and-regulates-the-levels-of-inflammatory-cytokines-in-adult-male-mice
#1
Qi Wang, Xiaomei Dong, Yan Wang, Mengxi Liu, Anji Sun, Nannan Li, Yiwei Lin, Zhongli Geng, Ye Jin, Xiaobai Li
There is little research on the effects of adolescent administration of antidepressants on behavioural function and inflammation in early-life stressed adult mice. Using maternal separation (MS), a paradigm of early adversity, we investigated the effects of adolescent (PND 33-54) escitalopram (ES; 10mg/kg) exposure on depression- and anxiety-like behaviours and the levels of inflammatory cytokines (interleukin [IL]-1β, tumor necrosis factor [TNF]-α, and IL-10) in the ventral hippocampus (HPV), prefrontal cortex (PFC), and serum in adult (PND 61) male offspring mice...
August 1, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28765079/developmental-neurotoxicity-and-autism-a-potential-link-between-indoor-neuroactive-pollutants-and-the-curious-birth-order-risk-factor
#2
REVIEW
Wesley A Gray, Vincent A Billock
Epidemiological and demographic studies find an increased risk of autism among first-borns. Toxicological studies show that some semi-volatile substances found in infant products produce adverse effects in neural and endocrine systems of animals, including behavioral and developmental effects. Several factors elevate the exposure of human infants to these chemicals. The highest exposures found in infants are comparable to the exposures that induce neural toxicity in animals. A review of these literatures suggests a linking hypothesis that could bridge the epidemiological and toxicological lines of evidence: an infant's exposure to neuroactive compounds emitted by infant products is increased by product newness and abundance; exposure is likely maximized for first-born children in families that can afford new products...
July 29, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28760642/galantamine-administration-reduces-reactive-astrogliosis-and-upregulates-the-anti-oxidant-enzyme-catalase-in-rats-submitted-to-neonatal-hypoxia-ischemia
#3
F K Odorcyk, F Nicola, L E Duran-Carabali, F Figueiró, J Kolling, A Vizuete, E L Konrath, C A Gonçalves, A T S Wyse, C A Netto
Neonatal hypoxia ischemia (HI) plays a role in the etiology of several neurological pathologies and causes severe sequelae. Acetylcholine is a neurotransmitter in the central nervous system and cholinesterase inhibitors have demonstrated a positive action over HI induced deficits. In order to evaluate the effects of pre and post-hypoxia administrations of galantamine, a cholinesterase inhibitor, in a model of perinatal HI, Wistar rats in the post-natal day 7 (PND7) were subjected to a combination of unilateral occlusion of the right carotid artery with the exposure to a 1h hypoxia...
July 29, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28760641/maternal-alterations-induced-by-exposure-to-an-unfamiliar-home-cage-in-early-underfed-dams
#4
Manuel Salas, Mirelta Regalado, Carmen Torrero, Lorena Rubio
The expression of different behavioral components in the adult rat depends on a number of early influences, including age, hormones, manipulations of sensory cues, and perinatal undernutrition, all of which impact the development of brain areas underlying adaptive processes, maternal behavior, and the response to novelty. The current study investigates the effects of pre- and neonatal undernutrition on various components of maternal behavior of dams exposed to the challenge of an unfamiliar home cage on days 4, 8, and 12 of lactation...
July 29, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28751239/experiencing-early-life-maternal-separation-increases-pain-sensitivity-in-adult-offspring
#5
Fabiana Cardoso Vilela, Jádina Santos Vieira, Alexandre Giusti-Paiva, Marcelo Lourenço da Silva
Maternal separation is a widely accepted model for studying long-term behavioral changes produced by events during early life and its association with changes in pain sensitivity. Thus, our objective was to evaluate sensitivity to pain, under different stimuli in adult male and female rats that had undergone early life maternal separation. Animals were subjected to maternal separation from postnatal day (PND) 2-15. Maternal behavior and litter weight were evaluated during this period. Sensitivity to pain was assessed in offsprings during adulthood by exposing them to stimuli, including formalin (5%; 20μl), a hot plate, and the electronic von Frey test, 4, 7, 10, and 24h after the administration of saline or Freund's complete adjuvant (CFA) injection...
July 25, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28716540/developmental-vitamin-d-deficiency-alters-multiple-neurotransmitter-systems-in-the-neonatal-rat-brain
#6
James P Kesby, Karly M Turner, Suzanne Alexander, Darryl W Eyles, John J McGrath, Thomas H J Burne
BACKGROUND: Epidemiological evidence suggests that developmental vitamin D (DVD) deficiency is a risk factor for neuropsychiatric disorders, such as schizophrenia. DVD deficiency in rats is associated with altered brain structure and adult behaviours indicating alterations in dopamine and glutamate signalling. Developmental alterations in dopamine neurotransmission have also been observed in DVD-deficient rats but a comprehensive assessment of brain neurochemistry has not been undertaken...
July 14, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28711670/evaluation-of-serum-neuron-specific-enolase-s100b-myelin-basic-protein-and-glial-fibrilliary-acidic-protein-as-brain-specific-proteins-in-children-with-autism-spectrum-disorder
#7
Erman Esnafoglu, Sema Nur Ayyıldız, Selma Cırrık, Emine Yurdakul Erturk, Abdullah Erdil, Abdullah Daglı, Tevfik Noyan
OBJECTIVE: Brain specific-proteins are not found in other tissues and measurement non-invasively in the blood may identify structurally and functionally damaged brain regions and identify the severity and prognosis of neuropsychiatric diseases. For this reason, we aimed to evaluate serum brain-specific protein values as brain damage markers in children with autism spectrum disorder (ASD). METHOD: 35 children with ASD and 31 healthy subjects were included in the study...
July 13, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28709820/sex-dependent-difference-in-the-relationship-between-adipose-tissue-cholesterol-efflux-and-estradiol-concentrations-in-young-healthy-humans
#8
Fatima Iqbal, William J Durham, Ayyash Melhem, Saleem Raslan, Tony T Tran, Traver J Wright, Rabia Asghar, Ken Fujise, Elena Volpi, Labros Sidossis, Nicola Abate, Melinda Sheffield-Moore, Demidmaa Tuvdendorj
BACKGROUND: Impaired adipose tissue function and lower levels of high density lipoprotein cholesterol (HDL-C) have been implicated in the development of vascular dementia, and metabolic diseases such as hypertension, atherosclerosis, type 2 diabetes (T2D) and metabolic syndrome. Interestingly, both the substrate fluxes in adipose tissue and HDL-C concentration differ between men and women. Moreover, adipose tissue cholesterol efflux has been implicated in modulation of HDL-C levels. Thus, we aimed to determine if the association between serum estradiol levels and adipose tissue cholesterol efflux is sex-dependent...
July 12, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28694195/hemoglobins-emerging-roles-in-mental-disorders-metabolical-genetical-and-immunological-aspects
#9
REVIEW
Meric A Altinoz, Bahri Ince
Hemoglobin (Hb) expression in the central nervous system is recently shown. Cooccurences of mental disorders (mainly bipolar disorder (BD) and tic disorders) with β- or α-thalassemia trait or erythrocytosis were witnessed, which may be due to peripheral or central hypoxia/hyperoxia or haplotypal gene interactions. β-Globin genes reside at 11p15.5 close to tyrosine hydroxylase, dopamine receptor DRD4 and Brain Derived Neurotrophic Factor, which involve in psychiatric diseases. α-Globin genes reside at 16p13...
July 8, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28690102/high-frequency-oscillations-after-median-nerve-stimulations-in-healthy-children-and-adolescents
#10
Sergio Zanini, Ivana Del Piero, Lucia Martucci, Domenico Restuccia
The aim of the present research was to address somatosensory high frequency oscillations (400-800Hz) in healthy children and adolescents in comparison with healthy adults. We recorded somatosensory evoked potentials following median nerve stimulation in nineteen resting healthy children/adolescents and in nineteen resting healthy adults with eyes closed. We administered six consecutive stimulation blocks (500 sweeps each). The presynaptic component of high frequency oscillations amplitudes was smaller in healthy children/adolescents than in healthy adults (no difference between groups was found as far as the postsynaptic component was concerned)...
July 6, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28684308/characterizing-ingestive-behavior-through-licking-microstructure-underlying-neurobiology-and-its-use-in-the-study-of-obesity-in-animal-models
#11
REVIEW
Alexander W Johnson
Ingestive behavior is controlled by multiple distinct peripheral and central physiological mechanisms that ultimately determine whether a particular food should be accepted or avoided. As rodents consume a fluid they display stereotyped rhythmic tongue movements, and by analyzing the temporal distribution of pauses of licking, it is possible through analyses of licking microstructure to uncover dissociable evaluative and motivational variables that contribute to ingestive behavior. The mean number of licks occurring within each burst of licking (burst and cluster size) reflects the palatability of the consumed solution, whereas the frequency of initiating novel bouts of licking behavior (burst and cluster number) is dependent upon the degree of gastrointestinal inhibition that accrues through continued fluid ingestion...
July 3, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28684307/discriminant-validity-of-spatial-and-temporal-postural-index-in-children-with-neurodevelopmental-disorders
#12
Maria Pia Bucci, Nathalie Goulème, Coline Stordeur, Eric Acquaviva, Isabelle Scheid, Aline Lefebvre, Christophe-Loïc Gerard, Hugo Peyre, Richard Delorme
Autism, learning disabilities and attention deficit/hyperactive disorder are often comorbid disorders. In order to try and find some markers that might be transnosographic, we hypothesized that abnormal postural sway profiles may discriminate children with neurodevelopmental disorders (NDDs) from typically developing children. The aim of our study was thus to compare spatial and temporal measures of the Center of Pressure in three distinct groups of children with NDDs (high functioning autism spectrum disorders, learning disabilities (dyslexia) and attention deficit/hyperactive disorders) and in typically developing children...
July 3, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28673682/efficient-neural-differentiation-of-mouse-pluripotent-stem-cells-in-a-serum-free-medium-and-development-of-a-novel-strategy-for-enrichment-of-neural-cells
#13
Isha Verma, Zubin Rashid, Sujit K Sikdar, Polani B Seshagiri
Pluripotent stem cells (PSCs) offer an excellent model to study neural development and function. Although various protocols have been developed to direct the differentiation of PSCs into desired neural cell types, many of them suffer from limitations including low efficiency, long duration of culture, and the use of expensive, labile, and undefined growth supplements. In this study, we achieved efficient differentiation of mouse PSCs to neural lineage, in the absence of exogenous molecules, by employing a serum-free culture medium containing knockout serum replacement (KSR)...
July 1, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28663041/maternal-intake-of-cashew-nuts-accelerates-reflex-maturation-and-facilitates-memory-in-the-offspring
#14
Marília Ferreira Frazão Tavares de Melo, Diego Elias Pereira, Morgana Moura Sousa, Dilian Maise Ferreira Medeiros, Leanderson Tulio Marques Lemos, Marta Suely Madruga, Nayane Medeiros Santos, Maria Elieidy Gomes de Oliveira, Camila Carolina de Menezes, Juliana Késsia Barbosa Soares
Essential fatty acids, being indispensable during the stages of pregnancy, lactation and infancy influence the transmission of nerve impulses and brain function, and cashew nuts are a good source of these fatty acids. The objective of this study was to evaluate the effects of cashew nut consumption on reflex development, memory and profile of fatty acids of rat offspring treated during pregnancy and lactation. The animals were divided into three groups: Control (CONT), treated with 7% lipid derived from soybean oil; Normolipidic (NL) treated with 7% lipids derived from cashew nuts; and Hyperlipidic (HL) treated with 20% lipids derived from cashew nuts...
June 27, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28652200/down-regulation-of-mirnas-in-the-brain-and-development-of-diet-induced-obesity
#15
Jaime G Maldonado-Avilés, Douglas J Guarnieri, Xianglong Zhu, Ralph J DiLeone
Novel therapeutic interventions for obesity and comorbid conditions require knowledge of the molecular elements playing a role in the development of obesity. Chronic low-grade inflammation has been consistently reported in obese individuals. In this study, we first determined whether key molecular modulators of inflammation, microRNA-155 (mir-155) and microRNA-146a (miR-146a), are regulated by an obesogenic diet within brain regions associated with reward, metabolism and energy balance. C57BL/6J mice were chronically exposed to a high fat diet (HFD) or a standard chow (CTL)...
June 23, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28641987/food-deprivation-in-f0-generation-and-hypercaloric-diet-in-f1-generation-reduce-f2-generation-astrogliosis-in-several-brain-areas-after-immune-challenge
#16
T B Ogassawara, A Joaquim, C P Coelho, M M Bernardi, E Teodorov, M F M Martins, T B Kirsten, L V Bonamin, P D Dossa, L B Viebig, E F Bondan
AIMS: The effects of maternal food restriction during gestation in F0 generation followed by hypercaloric diet (HD) during puberty in F1 generation (F1HD) were investigated on astrocyte behavior of F2 generation. Also, the astrocyte behavior, after an immune challenge, was examined by the immunohistochemical expression of glial fibrillary acidic protein (GFAP) in several brain areas. METHODS: The body weight gain (BW) during development and in postnatal day (PND) 90-95, the retroperitoneal fat weight (RPF), and the size of larger and smaller adipocytes in the F1 generation were assessed to observe the effects of HD in female rats...
June 19, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28636875/effects-of-prenatal-binge-like-ethanol-exposure-and-maternal-stress-on-postnatal-morphological-development-of-hippocampal-neurons-in-rats
#17
Ewa Jakubowska-Dogru, Birsen Elibol, Ilknur Dursun, Sinan Yürüker
BACKGROUND: Alcohol is one of the most commonly used drugs of abuse negatively affecting human health and it is known as a potent teratogen responsible for fetal alcohol syndrome (FAS), which is characterized by cognitive deficits especially pronounced in juveniles but ameliorating in adults. Searching for the potential morphological correlates of these effects, in this study, we compared the course of developmental changes in the morphology of principal hippocampal neurons in fetal-alcohol (A group), intubated control (IC group), and intact control male rats (C group) over a protracted period of the first two postnatal months...
June 19, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28559209/short-post-weaning-social-isolation-induces-long-term-changes-in-the-dopaminergic-system-and-increases-susceptibility-to-psychostimulants-in-female-rats
#18
Carine Lampert, Danusa Mar Arcego, Natividade de Sá Couto-Pereira, Aline Dos Santos Vieira, Ana Paula Toniazzo, Rachel Krolow, Emily Garcia, Deusa Aparecida Vendite, Maria Elisa Calcagnotto, Carla Dalmaz
Childhood and adolescence are sensitive periods of development, marked by high brain maturation and plasticity. Exposure to early life stress, such as social isolation, is able to prompt changes in sensitive brain circuitries, essentially in the mesolimbic dopaminergic system and increase the risk for addictive behaviors later in life. Post-weaning social isolation can stimulate the consumption of rewarding substances, like drugs of abuse and palatable foods. However, most studies analyze long periods of social isolation and very little is known about the effects of a brief social isolation in a sensitive period of development and its association with palatable food on the reward system sensitization...
May 27, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28655626/differential-effects-of-perinatal-exposure-to-antidepressants-on-learning-and-memory-acoustic-startle-anxiety-and-open-field-activity-in-sprague-dawley-rats
#19
Jenna L N Sprowles, Jillian R Hufgard, Arnold Gutierrez, Rebecca A Bailey, Sarah A Jablonski, Michael T Williams, Charles V Vorhees
Most antidepressants inhibit monoamine reuptake. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) act on the 5-HT transporter (SERT) whereas norepinephrine-dopamine reuptake inhibitors (NDRIs) act on the norepinephrine and dopamine transporters. Epidemiological reports link SSRI use during pregnancy to an increased prevalence of autism spectrum disorder (ASD). We previously showed that perinatal exposure to the SSRI citalopram (CIT) results in rodent offspring that exhibit a number of behaviors consistent with an ASD-like phenotype...
October 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28610974/positive-modulation-of-%C3%AE-5-gabaa-receptors-in-preadolescence-prevents-reduced-locomotor-response-to-amphetamine-in-adult-female-but-not-male-rats-prenatally-exposed-to-lipopolysaccharide
#20
Bojan Batinić, Anja Santrač, Ivan Jančić, Guanguan Li, Aleksandra Vidojević, Bojan Marković, James M Cook, Miroslav M Savić
We previously demonstrated that lipopolysaccharide (LPS) administered intraperitoneally (i.p.) to pregnant Wistar rat dams, at embryonic days 15 and 16 (E15/16), induced a decrease of baseline locomotor activity and diminished reactivity to amphetamine in adult female offspring. In the present study we aimed to assess the duration of LPS-induced maternal immune activation (MIA) and investigate possible changes in levels of main neurotransmitters in fetal brain during MIA. We hypothesized that the observed behavioral changes may be linked with MIA-induced disturbance of prenatal GABAergic system development, especially with α5 GABAA receptors (α5GABAARs), expression of which takes place between E14 and E17...
October 2017: International Journal of Developmental Neuroscience
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