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International Journal of Developmental Neuroscience

Dongdong Chai, Yanyong Cheng, Hong Jiang
Over the last three decades, advances in medical and surgical techniques have proven life saving and life-improving for young children. Consequently, early and repeated exposure to general anesthetics in childhood has increased. However, accumulating evidence suggests that general anesthetics may be neurotoxic in children. Of particular concern is the neurotoxicity fetuses may suffer from maternal exposure to sevoflurane during surgeries and fetal intervention procedures performed during the second trimester, as this can cause neurodevelopmental impairment in offspring...
November 15, 2018: International Journal of Developmental Neuroscience
Wen Li, Zhenshu Li, Dezheng Zhou, Xumei Zhang, Jing Yan, Guowei Huang
Embryonic development is a critical period wherein brain neurons are generated and organized. Maternal dietary folate, a cofactor in one-carbon metabolism, modulates neurogenesis and apoptosis in foetal brain neurons. We hypothesized that aberrant neuronal apoptosis may affect the development of the central nervous system during maternal folic acid deficiency, with evident effects because maternal folic acid deficiency modulates the microRNA-34a associated with Bcl-2 pathway during embryonic development. Four-week-old female Sprague-Dawley rats were divided randomly into two groups (10 rats per group): a folate-deficient diet group and a folate-normal diet group...
November 14, 2018: International Journal of Developmental Neuroscience
Gillian M Maher, Fergus P McCarthy, Cathal M McCarthy, Louise C Kenny, Patricia M Kearney, Ali S Khashan, Gerard W O'Keeffe
Pre-eclampsia is a leading cause of maternal death and maternal and perinatal morbidity. Whilst the clinical manifestations of pre-eclampsia often occur in late pregnancy, the molecular events leading into the onset of this disease are thought to originate in early pregnancy and result in insufficient placentation. Although the causative molecular basis of pre-eclampsia remains poorly understood, maternal inflammation is recognised as a core clinical feature. While the adverse effects of pre-eclampsia on maternal and fetal health in pregnancy is well-recognised, the long-term impact of pre-eclampsia exposure on the risk of autism spectrum disorder (ASD) in exposed offspring is a topic of on-going debate...
November 2, 2018: International Journal of Developmental Neuroscience
Amanda R Rendall, Peter A Perrino, Alexzandrea N Buscarello, R Holly Fitch
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by a core set of atypical behaviors in social-communicative and repetitive-motor domains. Individual profiles are widely heterogeneous and include language skills ranging from nonverbal to hyperlexic. The causal mechanisms underlying ASD remain poorly understood but appear to include a complex combination of polygenic and environmental risk factors. SHANK3 (SH3 and multiple ankyrin repeat domains 3) is one of a subset of well-replicated ASD-risk genes (i...
October 29, 2018: International Journal of Developmental Neuroscience
Wilmar Saldarriaga, María J Salcedo-Arellano, Tatiana Rodriguez-Guerrero, Marcela Ríos, Andrés Fandiño-Losada, Julian Ramirez-Cheyne, Pamela J Lein, Flora Tassone, Randi J Hagerman
Premutation carriers of the FMR1 gene (CGG repeats between 55 and 200) usually have normal intellectual abilities but approximately 20% are diagnosed with developmental problems or autism spectrum disorder. Additionally, close to 50% have psychiatric problems such as anxiety, ADHD and/or depression. The spectrum of fragile X disorders also includes Fragile-X-associated primary ovarian insufficiency (FXPOI) in female carriers and Fragile-X-associated tremor/ataxia syndrome (FXTAS) in older male and female carriers...
October 29, 2018: International Journal of Developmental Neuroscience
Bruna Ferrary Deniz, Heloísa Deola Confortim, Iohanna Deckmann, Patrícia Maidana Miguel, Loise Bronauth, Bruna Chaves de Oliveira, Milene Cardoso Vieira, Tiago Marcon Dos Santos, Carolina Gessinger Bertó, Josiane Hartwig, Ângela Terezinha de Souza Wyse, Lenir Orlandi Pereira
Folic acid (FA) is a B-complex vitamin important to the development of the fetus, being supplemented during pregnancy. Our recent findings showed that gestation supplementation (normal and excess doses) prevented the cognitive deficits and BDNF imbalance in adult rats that were submitted to neonatal hypoxia-ischemia (HI). To better understand this protective effect, the present study aimed to evaluate whether FA supplementation could be related to (1) maternal behavior, memory and Na+ , K+ - ATPase activity in the hippocampus of the dams; (2) on somatic growth, early neurobehavioral development and Na+ , K+ - ATPase activity in the hippocampus of the offspring; and (3) the effects of this supplementation in pups submitted to neonatal HI...
October 11, 2018: International Journal of Developmental Neuroscience
Hiroyuki Konishi, Hiroshi Kiyama, Masaki Ueno
Microglia colonize the central nervous system (CNS) parenchyma during embryogenesis and contribute to various developmental processes leading to the formation of refined neural circuits. In this review, we focus on the bidirectional function of microglia during normal CNS development and discuss recent perspectives on the functions of microglia in neural circuit formation. Microglia participate in neurogenesis, migration, axonal growth, and synapse formation and remodeling, all of which are fundamental for the establishment of neural networks, by secreting a variety of molecules toward neurons and phagocytosing both live and dying neurons or their debris...
October 4, 2018: International Journal of Developmental Neuroscience
Qian Wang, Cong Liu
Maternal exposure to lipopolysaccharide (LPS), a bacterial endotoxin produced during infection, leads to disruption in fetal brain development and causes newborn brain injury. Quercetin (QR) is a multipotent flavonoid that functions as an antioxidant and protects against inflammation and neurodegeneration. In this study, we explored the potential functions of QR in alleviating maternal LPS exposure induced fetal brain damage. Pregnant rats at late gestational stages were treated with saline, LPS, QR, LPS and QR...
September 30, 2018: International Journal of Developmental Neuroscience
Ya Guo, Yu Zhang, Fei Li, Peipei Liu, Yedan Liu, Chengqing Yang, Jie Song, Na Zhang, Zongbo Chen
Mutations in ATP6 gene are frequent causes of mitochondrial encephalomyopathies. ATP6 gene encodes one subunit of complexⅤ. The present study described a missense mutation in ATP6 gene in a 8-year-old Chinese boy with mitochondrial encephalomyopathy. We identified one missense mutation in ATP6 gene (m.8914C>T) by mitochondrial DNA sequencing. This mutation altered the amino acid proline in serine, and alterative protein is predicted to be harmful. The mutation load in blood sample of patient is 59.49%...
September 28, 2018: International Journal of Developmental Neuroscience
Marwa Ben Jdila, Chahnez Triki, Bochra Ben Rhouma, Rihab Ben Jomaa, Abir Ben Issa, Leila Ammar-Keskes, Fatma Kamoun, Faiza Fakhfakh
INTRODUCTION: West Syndrome is a severe epileptic encephalopathy characterized by epileptic spasms, hypsarrhythmia, and regression of psychomotor acquisitions beginning in the first year of life. ARX and CDKL5 genes were identified as linked to the most frequent genetic causes of West Syndrome. METHODS: The present study reports the clinical, molecular and bioinformatic investigation of the patient with severe West syndrome. RESULTS: Molecular analysis of the two candidate genes, i...
September 17, 2018: International Journal of Developmental Neuroscience
Pauline Maciel August, Rafael Moura Maurmann, André Brum Saccomori, Mariana Crestani Scortegagna, Eduardo Borges Flores, Caroline Peres Klein, Bernardo Gindri Dos Santos, Vinicius Stone, Bárbara Mariño Dal Magro, Leo Cristhian, Carolina Nunes Santo, Régis Hözer, Cristiane Matté
Prenatal and early postnatal environments can permanently influence health throughout life. Early overnutrition increases the risk to develop chronic diseases. Conversely, the intake of flavonoids and exercise practice during pregnancy seem to promote long-term benefits to offspring. We hypothesized that benefic interventions during pregnancy could protect against possible postnatal neurochemical alterations caused by overnutrition induced by reduced litter size. Female Wistar rats were divided into four groups: (1) sedentary + vehicle, (2) sedentary + naringenin, (3) swimming exercise + vehicle, and (4) swimming exercise + naringenin...
September 16, 2018: International Journal of Developmental Neuroscience
Rui Yang, Shao Liu, Yi Zheng, Mengqi Zhang, Ruili Dang, Mimi Tang
BACKGROUND: Polyunsaturated fatty acids (PUFAs) are normal components of growth and development and its derivatives especially n-3 PUFAs have an influence on the development and maturation of nervous system. The purpose of our present study was to investigate the effect of maternal n-3 PUFAs dietary on physical maturation and the neurobiological development of the rat offspring. METHODS: According to the content of n-3 PUFAs in their diets, female dams were randomly divided into three treatment groups (n = 6-7): deficiency, control and supplementation...
September 14, 2018: International Journal of Developmental Neuroscience
Min Liu, Yuhuan Wang, Sijia Yang, He Wei, Miao Tuo, Fei Chang, Yuhui Wang
OBJECTIVE: To identify candidate genes for the clinical diagnosis of floppy infant syndrome (FIS) using single nucleotide polymorphism (SNP) array in a specific FIS family. METHODS: SNP array analysis of the whole chromosome copy number was performed in the proband (III1 ). Multiple polymerase chain reaction (PCR) combined with denaturing high-performance liquid chromatography (DHPLC) was used to validate the array data. RESULTS: A large 5...
September 12, 2018: International Journal of Developmental Neuroscience
Yuanpei Zhang, Hongxuan Wang, Yi Li, Ying Peng
INTRODUCTION: Fetal alcohol spectrum disorder is caused by maternal ethanol exposure; it causes physical, behavioral, cognitive, and neural impairments (Murawski et al., 2015). Mechanisms of FASD causing damage are not yet fully elucidated. Oxidative stress might be one of its mechanisms (Henderson et al., 1995). Yet no effective treatment against FASD has been found other than ethanol abstention (Long et al., 2010). METHODS: This review summarizes relevant literatures regarding interventions targeting oxidative stress that may relieve fetal alcohol spectrum disorder...
September 8, 2018: International Journal of Developmental Neuroscience
Shuji Iritani, Youta Torii, Chikako Habuchi, Hirotaka Sekiguchi, Hiroshige Fujishiro, Mari Yoshida, Yasuhiro Go, Astushi Iriki, Masaki Isoda, Norio Ozaki
The precise biological etiology of autism spectrum disorder (ASD) remains unknown. In this study, we investigated the neuropathology of a monkey model of autism Human ABCA13 is the largest ABC transporter protein, with a length of 5058 amino acids and a predicted molecular weight of >450 kDa. However, the function of this protein remains to be elucidated. This protein is thought to be associated with major psychiatric disease. Using this monkey model of autism with an ABCA13 deletion and a mutation of 5HT2c, we neuropathologically investigated the changes in the neuronal formation in the frontal cortex...
September 7, 2018: International Journal of Developmental Neuroscience
Caroline Peres Klein, Karoline Dos Santos Rodrigues, Régis Mateus Hözer, Natividade de Sá Couto-Pereira, André Brum Saccomori, Bárbara Mariño Dal Magro, Mariana Scortegagna Crestani, Juliana Bender Hoppe, Christianne Gazzana Salbego, Carla Dalmaz, Cristiane Matté
Several environmental factors affect child development, such as the intrauterine environment during the embryonic and fetal development and early postnatal environment provided by maternal behavior. Although mechanistic effects of maternal exercise on offspring health improvement are not yet completely understood, the number of reports published demonstrating the positive influence of maternal exercise have increase. Herein, we addressed issues related to early postnatal environment provided by maternal behavior and early developmental physical landmarks, sensorimotor reflexes, and motor movements ontogeny...
August 30, 2018: International Journal of Developmental Neuroscience
Alex M Pagnozzi, Eugenia Conti, Sara Calderoni, Jurgen Fripp, Stephen E Rose
Autism Spectrum Disorder (ASD) affects approximately 1% of the population and leads to impairments in social interaction, communication and restricted, repetitive behaviours. Establishing robust neuroimaging biomarkers of ASD using structural magnetic resonance imaging (MRI) is an important step for diagnosing and tailoring treatment, particularly early in life when interventions can have the greatest effect. However currently, there is mixed findings on the structural brain changes associated with autism. Therefore in this systematic review, recent (post-2007), high-resolution (3 T) MRI studies investigating brain morphology associated with ASD have been collated to identify robust neuroimaging biomarkers of ASD...
August 30, 2018: International Journal of Developmental Neuroscience
Cassiana Siebert, Carolina Gessinger Bertó, Fernanda Silva Ferreira, Daniella de S Moreira, Tiago Marcon Dos Santos, Angela T S Wyse
The aim of this study was to verify the effects of ovariectomy (OVX) and/or vitamin D supplementation (VIT D) on inflammatory and cholinergic parameters in hippocampus, as well as on serum estradiol and VIT D levels of rats. Ninety-day-old female Wistar rats were randomly divided into four groups: SHAM, OVX, VIT D or OVX + VIT D. Thirty days after OVX, VIT D (500 IU/kg/day) was supplemented by gavage, for 30 days. Approximately 12 h after the last VIT D administration, rats were euthanized and hippocampus and serum were obtained for further analyses...
August 30, 2018: International Journal of Developmental Neuroscience
María Eugenia Bogetti, Victorio M Pozo Devoto, Melina Rapacioli, Vladimir Flores, Sara Fiszer de Plazas
A decrease in the concentration of oxygen in the blood and tissues (hypoxia) produces important, sometimes irreversible, damages in the central nervous system (CNS) both during development and also postnatally. The present work aims at analyzing the expression of nerve growth factor (NGF) and p75 and the activation of TrkA in response to an acute normobaric hypoxic event and to evaluate the possible protective role of exogenous NGF. The developing chick optic tectum (OT), a recognized model of corticogenesis, was used as experimental system by means of in vivo and in vitro studies...
August 27, 2018: International Journal of Developmental Neuroscience
Rupali Sharma, Jasmine Rooke, Daria Kolmogorova, Brett Melanson, Jean-François Mallet, Chantal Matar, Jaclyn Schwarz, Nafissa Ismail
Puberty is a critical developmental period that is characterized by significant brain development. Exposure to stress during this time can alter brain functioning setting the stage for long-lasting behavioural outcomes. The objective of this study was to investigate age and sex differences in the peripheral and central immune responses, along with sickness behaviour, following immune stress. The results showed that LPS treatment increased serum cytokine levels and sickness symptoms in all mice. Pubertal males displayed increased IL-1β concentrations at 2 h and increased IL-6 concentrations at 8 h post-treatment whereas increased concentrations of TNFα, IL-10, IL-12, IL-1β, IFNγ, and IL-6 persisted at 8 and 24 h in adult females...
August 27, 2018: International Journal of Developmental Neuroscience
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