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International Journal of Developmental Neuroscience

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https://www.readbyqxmd.com/read/29791868/ontogeny-of-white-matter-toll-like-receptor-expression-and-motor-skills-in-the-neonatal-ferret
#1
Jessica M Snyder, Thomas R Wood, Kylie Corry, Daniel H Moralejo, Pratik Parikh, Sandra E Juul
Inflammation caused by perinatal infection, superimposed with hypoxia and/or hyperoxia, appears to be important in the pathogenesis of preterm neonatal encephalopathy, with white matter particularly vulnerable during the third trimester. The associated inflammatory response is at least partly mediated through Toll-like receptor (TLR)-dependent mechanisms. Immunohistochemistry, gene expression, and behavioral studies were used to characterize white matter development and determine TLR3 and TLR4 expression and accumulation in the neonatal ferret brain...
May 20, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29787797/developing-neurites-from-mouse-basal-forebrain-gonadotropin-releasing-hormone-neurons-use-sonic-hedgehog-to-modulate-their-growth
#2
C L Tan, P W Sheard, C L Jasoni
Hypothalamic gonadotropin-releasing hormone (GnRH) neurons are required for fertility in all mammalian species studied to date. GnRH neuron cell bodies reside in the basal forebrain, and most extend long neurites in the caudal direction to terminate at the median eminence (ME), the site of hormone secretion. Using in vitro neurite growth assays, histological methods, and genetic deletion strategies in mice we have analysed the role of the morphogen and neurite growth and guidance molecule, Sonic hedgehog (Shh), in the growth of GnRH neurites to their target...
May 19, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29763658/event-related-potential-analysis-techniques-for-autism-spectrum-disorders-a-review
#3
REVIEW
Priyalakshmi Sheela, Subha D Puthankattil
Autism Spectrum Disorders (ASD) comprise all pervasive neurodevelopmental diseases marked by deficits in social and communication skills, delayed cognitive development, restricted and repetitive behaviors. The core symptoms begin in early childhood, may continue life-long resulting in poor performance in adult stage. Event-related potential (ERP) is basically a time-locked electroencephalogram signal elicited by various stimuli, related to sensory and cognitive processes. The various ERP based techniques used for the study of ASD are considered in this review...
May 12, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29758348/effect-of-prenatal-stress-on-%C3%A9-5-gaba-a-receptor-subunit-gene-expression-in-hippocampus-and-pilocarpine-induced-seizure-in-rats
#4
Mehrdad Nejatbakhsh, Ehsan Saboory, Morteza Bagheri
The GABAergic synapses go through structural and functional maturation during early brain development. Maternal stress alters GABAergic synapses in developing brain, which are associated with the pathophysiology of neuropsychiatric disorders in adults. The present study aimed to investigate the effect of prenatal restraint stress (PS) on pilocarpine-induced seizure and ɑ5 subunit of γ-amino butyric acid type A (GABAA ) receptor expression in hippocampus. Pregnant Wistar rats were subjected to PS at gestational days 15-17 and the pups were examined for susceptibility to seizure and ɑ5 subunit of GABAA receptor expression in hippocampus at postnatal days 14 and 21 (P14 and PND 21)...
May 11, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29758347/gene-analysis-a-rare-gene-disease-of-intellectual-deficiency-cohen-syndrome
#5
Chengqing Yang, Mei Hou, Yutang Li, Dianrong Sun, Ya Guo, Peipei Liu, Yedan Liu, Jie Song, Na Zhang, Wei Wei, Zongbo Chen
Cohen syndrome is a rare, genetic, connective-tissue disorder, which is caused by mutations in the gene COH1 (VPS13B, Vacuolar Protein Sorting 13 Homolog B) at the chromosome 8q22. The disease is rare reported, which major clinical features include postnatal microcephaly, obesity, short stature, intellectual disability, progressive retinal dystrophy, intermittent neutropenia and many other unusual facial feature. We report four patients in China who were diagnosed with Cohen syndrome by genetic testing and clinical manifestations...
May 11, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29730049/cafeteria-diet-during-the-gestation-period-programs-developmental-and-behavioral-courses-in-the-offspring
#6
Ana Cláudia Alves Freire Ribeiro, Tatiane Helena Batista, Vanessa Barbosa Veronesi, Alexandre Giusti-Paiva, Fabiana Cardoso Vilela
The objective of this study was to investigate the effect of exposure to maternal consumption of a hyperenergetic, highly palatable diet, known as the cafeteria diet, during the gestation period on the development and behavior of offspring. For this, we used pregnant female mice that were fed a normal or a cafeteria diet during the gestation period. The evaluation of maternal behavior in lactating dams was performed from the second to the eighth day postpartum (PND 2 - 8). Weight gain, feed intake, and energy intake were recorded during the gestation period...
May 3, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29705589/prevalence-and-correlates-of-neurological-soft-signs-in-healthy-controls-without-family-history-of-any-mental-disorder-a-neurodevelopmental-variation-rather-than-a-specific-risk-factor
#7
Konstantinos N Fountoulakis, Panagiotis Panagiotidis, Vasilios Kimiskidis, Ioannis Nimatoudis, Xenia Gonda
OBJECTIVE: Neurological soft signs (NSS) are a group of minor non-localizable neurological abnormalities found more often in patients with schizophrenia and other mental disorders. The aim of the current study was to investigate their prevalence and correlates in healthy controls without family history of any mental disorder. MATERIAL AND METHODS: The study sample included 122 normal subjects (66 males and 56 females; aged 32.89 ± 9.91 years old). The assessment included the Neurological Evaluation Scale (NES), and a number of scales assessing the subthreshold symptoms (MADRS, STAI) and functioning (GAF)...
April 26, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29698661/visual-evoked-potentials-are-similar-in-polysomnographically-defined-quiet-and-active-sleep-in-healthy-newborns
#8
Lourdes Cubero-Rego, María Corsi-Cabrera, Josefina Ricardo-Garcell, Rogelio Cruz-Martínez, Thalía Harmony
No abstract text is available yet for this article.
April 23, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29689339/mitochondrial-dysfunction-is-implicated-in-retinoic-acid-induced-spina-bifida-aperta-in-rat-fetuses
#9
Jia Xue, Hui Gu, Dan Liu, Wei Ma, Xiaowei Wei, Lianshuai Zhao, Yusi Liu, Chaonan Zhang, Zhengwei Yuan
Neural tube defects (NTDs) are the most common and severe congenital malformations, which result from failure of the neural tube to close during embryonic development. The etiology of NTDs is complex, caused by interactions between genetic defects and environmental factors, but the exact mechanisms of this disease are still not fully understood. We herein employ a Seahorse Bioscience microplate-based extracellular flux (XF) analyzer to determine mitochondrial function and quantify respiratory coupling to various bioenergetic functions using specific pharmacological inhibitors of bioenergetic pathways...
April 21, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29689338/the-ketogenic-diet-in-disease-and-development
#10
REVIEW
Denis Barry, Sarah Ellul, Lindsey Watters, David Lee, Robert Haluska, Robin White
The ketogenic diet, low in carbohydrates and high in fat, was initially designed to reduce seizure onset in epilepsy. More recent evidence has shown its effectiveness in the treatment of movement and psychological disorders, and in general health maintenance. The cellular significance of ketone body metabolism during development and in the adult central nervous system is being revealed; however, the effects of replacing glucose with ketone bodies as the brains primary energy source especially in pregnancy are not fully understood...
April 21, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29689337/gender-specific-desensitization-of-group-i-metabotropic-glutamate-receptors-after-maternal-l-glutamate-intake-during-lactation
#11
Antonio López-Zapata, David Agustín León-Navarro, María Crespo, Mairena Martín
In the present work we have studied the effect of maternal intake of l-Glutamate (l-Glu) (1 g/L) during lactation on group I mGluR transduction pathway in brain plasma membrane from 15 days-old neonates. Results obtained have shown that maternal l-glutamate intake did not significantly affect neither weights of pups nor negative geotaxis reflex, an index of neurobehavioral development, but increased l-Glu plasma level in both male and female neonates. In male neonates, maternal l-Glu intake evoked a loss of mGluR1 whereas no variation on mGluR5 was observed as revealed by Western-blotting assay...
April 21, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29678562/effects-of-postnatal-handling-on-adult-behavior-and-brain-mrna-expression-of-serotonin-receptor-brain-derived-neurotrophic-factor-and-gaba-a-receptor-subunit
#12
Haiyan Li, Chihiro Ishikawa, Takashi Shiga
Development of brain and behavior is influenced by the interaction of genetic and environmental factors. Postnatal handling, a manipulation that briefly separates mouse offspring from their mother during the postnatal period, has been reported to yield beneficial effects on the behavior of adult offspring. However, brain mechanisms underlying the effects on the behavior have not been well understood. Here we first examined effects of postnatal handling on the behavior of adult male BALB/c mice. Offspring were separated for 15 min every day between postnatal day 1 (P1) and P14 and then various behaviors were tested in the adulthood...
April 17, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29653151/selective-decline-in-the-prevalence-of-slowly-adapting-type-i-mechanoreceptors-during-development
#13
Peter M B Cahusac, Solomon Senok
Merkel nerve endings are identified physiologically as slowly adapting type I mechanoreceptor units. They are important for fine acuity tactile perception. We examined the effect of age on the electrophysiological availability of different types of slowly adapting mechanoreceptor units. Using 6 - 50 week old rats, we observed an obvious decline with age in the probability of recording from St I units of the deep vibrissal nerve. The precipitous decline occurred between ages 6 - 14 weeks and then stabilized...
April 10, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29608930/atomoxetine-a-selective-norepinephrine-reuptake-inhibitor-improves-short-term-histological-outcomes-after-hypoxic-ischemic-brain-injury-in-the-neonatal-male-rat
#14
Masatake Toshimitsu, Yoshimasa Kamei, Mari Ichinose, Takahiro Seyama, Shinya Imada, Takayuki Iriyama, Tomoyuki Fujii
BACKGROUND: Despite the recent progress of perinatal medicine, perinatal hypoxic-ischemic (HI) insult remains an important cause of brain injury in neonates, and is pathologically characterized by neuronal loss and the presence of microglia. Neurotransmitters, such as norepinephrine (NE) and glutamate, are involved in the pathogenesis of hypoxic-ischemic encephalopathy via the interaction between neurons and microglia. Although it is well known that the monoamine neurotransmitter NE acts as an anti-inflammatory agent in the brain under pathological conditions, its effects on perinatal HI insult remains elusive...
March 30, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29605566/therapeutic-effect-of-perinatal-exogenous-melatonin-on-behavioral-and-histopathological-changes-and-antioxidative-enzymes-in-neonate-mouse-model-of-cortical-malformation
#15
Maryam Azizi, Parichehr Pasbakhsh, Seyed Alireza Nadji, Mihan Pourabdollah, Tahmineh Mokhtari, Makan Sadr, Negar Omidi, Iraj Ragerdi Kashani, Adib Zendehdel
BACKGROUND: Melatonin, which is an antioxidant and neuroprotective agent, can be an effective treatment for neurological disorders. We assessed the effect of melatonin administration on histological changes, antioxidant enzyme levels, and behavioral changes in a neonate mouse model of cortical malformation. MATERIALS AND METHODS: Cortical malformation was induced by two injections of 15 mg/kg methylazoxymethanol (MAM) on gestational day 15 (E15). Pregnant Balb/c mice were randomly divided into the following six groups: Control (CO), Melatonin (MEL), Luzindole (LUZ), MAM, MEL + MAM1 (co-treatment), and MEL + MAM2 (pretreatment)...
March 29, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29604340/a-case-of-pitt-hopkins-syndrome-with-de-novo-mutation-in-tcf4-clinical-features-and-treatment-for-epilepsy
#16
Yedan Liu, Ya Guo, Peipei Liu, Fei Li, Chengqing Yang, Jie Song, Jingfei Hu, Dandan Xin, Zongbo Chen
Pitt-Hopkins syndrome (PTHS), belonging to the group of 18q-syndromes, is a rare genetic disorder caused by mutations in TCF4. PTHS is characterized by distinctive facial appearance, intermittent hyperventilation, intellectual disability and developmental delay. Although patients with PTHS generally have various systemic symptoms, most of themwith a TCF4 mutation manifest the central nervous system (CNS) disorders. We described the first Chinese case with Pitt-Hopkins syndrome based on clinical presentations and genetic findings...
March 28, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29604339/expression-of-the-long-non-coding-rna-h19-and-malat-1-in-growth-hormone-secreting-pituitary-adenomas-and-its-relationship-to-tumor-behavior
#17
Tianyu Lu, Chen Yu, Hongbin Ni, Weibang Liang, Huiying Yan, Wei Jin
Aggressive growth hormone-secreting pituitary adenomas (GHPAs) represent an important clinical problem in patients with acromegaly. Surgical therapy, although often the mainstay of treatment for GHPAs, is less effective in aggressive GHPAs due to their invasive and destructive growth patterns, and their proclivity for infrasellar invasion. LncRNAs are important players in cancer development and emerging in various fundamental biological processes. In the present study, qRT-PCR was performed to examine the expression of lncRNA H19 and MALAT-1 in invasive and non-invasive GHPAs...
March 28, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29555564/neurogenesis-in-the-postnatal-cerebellum-after-injury
#18
REVIEW
Julia P Andreotti, Pedro H D M Prazeres, Luiz A V Magno, Marco A Romano-Silva, Akiva Mintz, Alexander Birbrair
The cerebellum plays major role in motor coordination and learning. It contains half of the neurons in the brain. Thus, deciphering the mechanisms by which cerebellar neurons are generated is essential to understand the cerebellar functions and the pathologies associated with it. In a recent study, Wojcinski et al. (2017) by using in vivo Cre/loxP technologies reveal that Nestin-expressing progenitors repopulated the external granular cell layer after injury. Depletion of postnatal external granular cell layer is not sufficient to induce motor behavior defects in adults, as the cerebellum recovers these neurons...
March 16, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29555563/brain-derived-neutrophic-factor-in-adolescents-smoking-waterpipe-the-irbid-try
#19
Mahmoud A Alomari, Nihaya A Al-Sheyab, Omar F Khabour, Karem H Alzoubi
BACKGROUND: Brain-derived neutrophic factor (BDNF) and tobacco consumption can affect many body functions and health. However, the relationship of BDNF with waterpipe (Wp) smoking is unknown. Therefore, the current study examined the relationship between Wp smoking and BDNF in adolescents. METHODS: Self-reported tobacco consumption and serum BDNF were determined in 195 waterpipe and 288 nonsmokers in 7th-10th grade students. RESULTS: Stepwise regression that included Wp smoking, gender, BMI, and location, showed that only Wp smoking (p < 0...
March 16, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29571720/prenatal-exposure-to-modafinil-alters-behavioural-response-to-methamphetamine-in-adult-male-mice
#20
Jana Ruda-Kucerova, Jana Pistovcakova, Petra Amchova, Alexandra Sulcova, Alena Machalova
Modafinil is a psychostimulant drug prescribed for treatment of narcolepsy. However, it is used as a "smart drug" especially by young adults to increase wakefulness, concentration and mental performance. Therefore, it can also be used by women with childbearing potential and its developmental effects can become a concern. The aim of this study was to assess behavioural and immune effects of prenatal modafinil exposure in mice and to evaluate the reaction to methamphetamine exposure on these animals in adult age...
June 2018: International Journal of Developmental Neuroscience
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