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International Journal of Developmental Neuroscience

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https://www.readbyqxmd.com/read/29233724/caprine-neonatal-spinal-ultrasonography
#1
Elham A Hassan, Khaled M Ali, Faisal A Torad
Spinal ultrasonography is a safe, rapid, and non-invasive diagnostic tool that allows visualization of the spinal cord and its surrounding meninges. The non-ossified spinous processes were used as an acoustic window for imaging the spinal cord in human and canine neonates. No available literatures have been published describing the ultrasonographic appearance of caprine neonatal spinal cord. The present study was performed on 20 one day-old goat kids. Sagittal and transverse ultrasound scans were obtained using 8MHz linear transducer...
December 9, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29197565/molecular-and-biochemical-biomarkers-for-diagnosis-and-therapy-monitorization-of-niemann-pick-type-c-patients
#2
Tatiane Grazieli Hammerschmidt, Graziela de Oliveira Schmitt Ribas, Maria Luiza Saraiva-Pereira, Márcia Polese Bonatto, Rejane Gus Kessler, Fernanda Timm Seabra Souza, Franciele Trapp, Kristiane Michelin-Tirelli, Maira Graeff Burin, Roberto Giugliani, Carmen Regla Vargas
BACKGROUND: Niemann-Pick type C (NP-C), one of 50 inherited lysosomal storage disorders, is caused by NPC protein impairment that leads to unesterified cholesterol accumulation in late endosomal/lysosomal compartments. The clinical manifestations of NP-C include hepatosplenomegaly, neurological and psychiatric symptoms. Current diagnosis for NP-C is based on observation of the accumulated cholesterol in fibroblasts of affected individuals, using an invasive and time expensive test, called Filipin staining...
November 29, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29196093/sonic-hedgehog-regulates-the-pathfinding-of-descending-serotonergic-axons-in-hindbrain-in-collaboration-with-wnt5a-and-secreted-frizzled-related-protein-1
#3
Jie Xie, Teng Zhao, Yaobo Liu
Previous studies have demonstrated that both Wnt5a and Sonic hedgehog (Shh) are involved in regulating the pathfinding of descending serotonergic (5-HT, 5-hydroxytryptamine) axons in an opposite manner in the brainstem. Shh and Wnt signaling pathways interact to guide post-crossing commissural axons, where Shh acts as a repellent directly and shaping the Wnt gradient indirectly by regulating the gradient expression of the frizzled-related protein 1 (Sfrp1). Whether such a mechanism functions in descending 5-HT axon guidance remains unknown...
November 28, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29196092/neurocognitive-and-developmental-perspectives-of-obesity
#4
EDITORIAL
Jonathan D Hommel
No abstract text is available yet for this article.
November 28, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29183706/differential-behavioral-phenotypes-of-dopamine-d1-receptor-knockdown-mice-at-the-embryonic-postnatal-and-adult-stages
#5
Tadashi Okubo, Asako Sato, Hirotsugu Okamoto, Toshiya Sato, Toshikuni Sasaoka
Dopamine is widely involved in behaviors related to motor activity, cognition, motivation, and reward. Dopamine signal is transduced through the dopamine receptor gene family. The dopamine D1 receptor (D1R) is highly expressed in the striatum, and is responsible for regulating the motor function. Recently, we have reported that the knockdown (KD) mice in which D1R was conditionally eliminated at adult stage, displayed a hypoactivity in the home cage than wild type mice; however, conventional D1R knockout (KO) mice show hyperactive phenotypes...
November 25, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29174061/pathobiological-expression-of-the-brain-derived-neurotrophic-factor-bdnf-in-cerebellar-cortex-of-sudden-fetal-and-infant-death-victims
#6
Anna M Lavezzi, Stefano Ferrero, Debora Lattuada, Francesco Piscioli, Graziella Alfonsi, Luigi Matturri
Brain-derived neurotrophic factor (BDNF), a neurotrophin of the central nervous system, is able to regulate neuronal differentiation and modulate synaptic plasticity, being particularly involved in the development of the cerebellar cortical structure. The main aim of this study was to delineate, by immunohistochemistry, the BDNF expression in human cerebellar cortex of victims of fetal and infant death. The study was performed on a total of 45 cases, aged between 25 gestational weeks and 6 postnatal months, including 29 victims of sudden fetal and infant death and 16 age-matched subjects who died of known causes (controls)...
November 22, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29146211/using-parent-and-self-reports-to-evaluate-eating-disturbances-in-young-girls-with-autism-spectrum-disorder
#7
Vicki Bitsika, Christopher F Sharpley
BACKGROUND: Eating Disturbances (ED) often occur in Autism Spectrum Disorder (ASD) but most previous studies have relied on parent-reported data about males with ASD. Few studies have collected data from younger girls with ASD using self-reports and parents' reports. AIMS: To compare self-reports and parents' reports of ED in a sample of 52 young girls with ASD, a standardised scale for ED was revised for use with younger girls with ASD. METHODS: Mothers of 52 girls with ASD aged from 6 to 17 years completed the Swedish Eating Assessment for Autism spectrum disorders (SWEAA) on their daughters; the girls also completed the SWEAA as a self-report...
November 13, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29126862/cortical-activity-in-fine-motor-tasks-in-children-with-developmental-coordination-disorder-a-preliminary-fnirs-study
#8
Priscila Caçola, Nancy Getchell, Dhivya Srinivasan, Georgios Alexandrakis, Hanli Liu
Developmental Coordination Disorder (DCD) is as a neurodevelopmental condition characterized by poor motor proficiency, which impacts academic performance and activities of daily living. Several studies have determined that children with DCD activate different regions of the brain when performing motor skills in comparison to typically developing (TD) children. However, none have used Functional Near-Infrared Spectroscopy (fNIRS) to explore cortical activation in this population. With that, the goal of this preliminary study was to investigate cortical activation using fNIRS in six children with DCD and six TD children between ages of 8 and 12 years...
November 7, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29111178/dose-dependent-neurocognitive-deficits-following-postnatal-day-10-hiv-1-viral-protein-exposure-relationship-to-hippocampal-anatomy-parameters
#9
Sylvia Fitting, Kristen A McLaurin, Rosemarie M Booze, Charles F Mactutus
Despite the availability of antiretroviral prophylactic treatment, pediatric human immunodeficiency virus type 1 (HIV-1) continues to be a significant risk factor in the post-cART era. The time of infection (i.e., during pregnancy, delivery or breastfeeding) may play a role in the development of neurocognitive deficits in pediatric HIV-1. HIV-1 viral protein exposure on postnatal day (P)1, preceding the postnatal brain growth spurt in rats, had deleterious effects on neurocognitive development and anatomical parameters of the hippocampus (Fitting et al...
October 27, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29079121/alterations-in-inter-alpha-inhibitor-protein-expression-after-hypoxic-ischemic-brain-injury-in-neonatal-rats
#10
Clémence Disdier, Jiyong Zhang, Yuki Fukunaga, Yow-Pin Lim, Joseph Qiu, Andre Santoso, Barbara S Stonestreet
Hypoxic-ischemic (HI) brain injury is frequently associated with premature and/or full-term birth-related complications that reflect widespread damage to cerebral cortical structures. Inflammation has been implicated in the long-term evolution and severity of HI brain injury. Inter-Alpha Inhibitor Proteins (IAIPs) are immune modulator proteins that are reduced in systemic neonatal inflammatory states. We have shown that endogenous IAIPs are present in neurons, astrocytes and microglia and that exogenous treatment with human plasma purified IAIPs decreases neuronal injury and improves behavioral outcomes in neonatal rats with HI brain injury...
October 25, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28941704/mir-194-is-involved-in-morphogenesis-of-spiral-ganglion-neurons-in-inner-ear-by-rearranging-actin-cytoskeleton-via-targeting-rhob
#11
Jintao Du, Xuemei Zhang, Hui Cao, Di Jiang, Xianren Wang, Wei Zhou, Kaitian Chen, Jiao Zhou, Hongyan Jiang, Luo Ba
Many microRNAs participate in the development, differentiation and function preservation of the embryonic and adult inner ear, but many details still need to be elucidated regarding the numerous microRNAs in the inner ear. Based on previous investigations on the microRNA profile in the inner ear, we confirmed that several microRNAs are expressed in the inner ear, and we detected the spatial expression of these microRNAs in the neonatal mouse inner ear. Then we focused on miR-194 for its specific expression with a dynamic spatiotemporal pattern during inner ear development...
December 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28888818/consequences-of-perinatal-hypoxia-in-developing-brain-changes-in-gaba-transporter-functioning-in-cortical-hippocampal-and-thalamic-rat-nerve-terminals
#12
Natalia Pozdnyakova
Perinatal hypoxia leads to behavioral abnormalities, cognitive disabilities, and epilepsy resulting from alterations in neurodevelopment, maturation and construction of the network. Considering a particular role of γ-aminobutyric acid (GABA) for an immature brain, we analysed transporter-mediated [(3)H]GABA uptake in the cortical, hippocampal and thalamic nerve terminals isolated from rats of different age in the control and after perinatal hypoxia. The state of hypoxia was induced by exposure of rats at the age of 10 postnatal days (pd) (that corresponds approximately to the time of birth in humans) to a respiratory medium with low O2 content (4% O2 and 96%N2) for 12min (up to the initiation of clonico-tonic seizures)...
December 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28887013/morphine-exposure-and-maternal-deprivation-during-the-early-postnatal-period-alter-neuromotor-development-and-nerve-growth-factor-levels
#13
Carla de Oliveira, Vanessa L Scarabelot, Rafael Vercelino, Natalia P Silveira, Lauren N S Adachi, Gabriela G Regner, Lisiane S Silva, Isabel Cristina de Macedo, Andressa de Souza, Wolnei Caumo, Iraci L S Torres
The objective of this study was to verify whether repeated morphine administration and maternal deprivation in early life alter neurobehavioral development and central nerve growth factor (NGF) levels. A total of 58 male Wistar rat pups were used in our study. From postnatal day 1 (P1), litters were daily deprived of their mother for 3h; this was continued for the first 10days of life. Animals were divided into 5 groups: total control (C), did not receive any intervention; saline (S), received saline solution; morphine (M), received morphine; deprived-saline group (DS), were subjected to maternal deprivation and received saline solution; and deprived-morphine (DM), were subjected to maternal deprivation and received morphine...
December 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28859888/postnatal-development-of-gabaergic-interneurons-and-perineuronal-nets-in-mouse-temporal-cortex-subregions
#14
Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Motoi Okamoto, Shozo Aoki, Takeshi Ishihara
In human neuropsychiatric disorders, there are functional and anatomical abnormalities of GABAergic interneurons in each temporal cortex subregion. Furthermore, accumulation of amyloid-β is observed in the temporal cortex in the early stages of Alzheimer's disease. Each subregion of the temporal cortex has an important role in coordinating the input and output of the hippocampus. When subregions of the temporal cortex are impaired, memory and learning ability decrease. GABAergic interneurons control excitatory neurons, forming the cortico-cortical and cortico-hippocampal networks...
December 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28765079/developmental-neurotoxicity-and-autism-a-potential-link-between-indoor-neuroactive-pollutants-and-the-curious-birth-order-risk-factor
#15
REVIEW
Wesley A Gray, Vincent A Billock
Epidemiological and demographic studies find an increased risk of autism among first-borns. Toxicological studies show that some semi-volatile substances found in infant products produce adverse effects in neural and endocrine systems of animals, including behavioral and developmental effects. Several factors elevate the exposure of human infants to these chemicals. The highest exposures found in infants are comparable to the exposures that induce neural toxicity in animals. A review of these literatures suggests a linking hypothesis that could bridge the epidemiological and toxicological lines of evidence: an infant's exposure to neuroactive compounds emitted by infant products is increased by product newness and abundance; exposure is likely maximized for first-born children in families that can afford new products...
November 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28330827/intrauterine-exposure-to-maternal-stress-alters-bdnf-iv-dna-methylation-and-telomere-length-in-the-brain-of-adult-rat-offspring
#16
Jennifer Blaze, Arun Asok, Kristyn Borrelli, Christina Tulbert, Justin Bollinger, April E Ronca, Tania L Roth
DNA methylation (addition of methyl groups to cytosines) and changes in telomere length (TTAGGG repeats on the ends of chromosomes) are two molecular modifications that result from stress and could contribute to the long-term effects of intrauterine exposure to maternal stress on offspring behavior. Here, we measured methylation of DNA associated with the Brain-derived neurotrophic factor (Bdnf) gene, a gene important in development and plasticity, and telomere length in the brains of adult rat male and female offspring whose mothers were exposed to unpredictable and variable stressors throughout gestation...
November 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28229923/epigenetic-regulation-of-reln-and-gad1-in-the-frontal-cortex-fc-of-autism-spectrum-disorder-asd-subjects
#17
Adrian Zhubi, Ying Chen, Alessandro Guidotti, Dennis R Grayson
Both Reelin (RELN) and glutamate decarboxylase 67 (GAD1) have been implicated in the pathophysiology of Autism Spectrum Disorders (ASD). We have previously shown that both mRNAs are reduced in the cerebella (CB) of ASD subjects through a mechanism that involves increases in the amounts of MECP2 binding to the corresponding promoters. In the current study, we examined the expression of RELN, GAD1, GAD2, and several other mRNAs implicated in this disorder in the frontal cortices (FC) of ASD and CON subjects. We also focused on the role that epigenetic processes play in the regulation of these genes in ASD brain...
November 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29054611/maternal-undernutrition-during-lactation-alters-nicotine-reward-and-dopac-dopamine-ratio-in-cerebral-cortex-in-adolescent-mice-but-does-not-affect-nicotine-induced-nachrs-upregulation
#18
Ana C Dutra-Tavares, Juliana O Silva, André L Nunes-Freitas, Vinícius M S Guimarães, Ulisses C Araújo, Ellen P S Conceição, Egberto G Moura, Patrícia C Lisboa, Cláudio C Filgueiras, Alex C Manhães, Yael Abreu-Villaça, Anderson Ribeiro-Carvalho
Early undernutrition causes long lasting alterations that affect the response to psychoactive drugs. Particularly, undernutrition during lactation affects the acute locomotor response to nicotine during adolescence, but the reward effect of continued exposure to nicotine remains unknown. The goal of this study was to investigate the effects of undernutrition during lactation on the nicotine susceptibility indexed via conditioned place preference (CPP), on dopamine content and turnover and on nicotine-induced nicotinic cholinergic receptor (nAChR) upregulation in the cerebral cortex, midbrain and hippocampus of adolescent mice...
October 18, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29051031/inflammatory-molecules-and-neurotrophic-factors-as-biomarkers-of-neuropsychomotor-development-in-preterm-neonates-a-systematic-review
#19
REVIEW
Rafael C Magalhães, Letícia P Pimenta, Izabela G Barbosa, Janaina M Moreira, João L V M de Barros, Antônio L Teixeira, Ana C Simões E Silva
OBJECTIVE: To provide a systematic review investigating the role of inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates. DATA SOURCE: Databases including PubMed, BIREME, and Scopus were systematically searched. Observational studies, as well as transversal, and cohort studies using human subjects published from 1990 to September 2017 were eligible for inclusion. Two authors independently identified eligible studies and analyzed their characteristics, quality, and accuracy in depth...
October 16, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29037912/early-emergence-of-altered-5-ht2a-receptor-evoked-behavior-neural-activation-and-gene-expression-following-maternal-separation
#20
Ankit Sood, Sthitapranjya Pati, Amrita Bhattacharya, Karina Chaudhari, Vidita A Vaidya
The early stress of Maternal Separation (MS) contributes to the establishment of adult psychopathology. The serotonergic (5-HT) system is implicated during this temporal window in mediating the development of mood-related behaviors. MS is reported to evoke altered 5-HT2A receptor function in adulthood. However, the ontogeny of altered 5-HT2A receptor responsivity following MS remains unknown. Here, we examined 5-HT2A receptor agonist, DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) (2mg/kg) evoked responses, namely stereotypical head-twitch behaviors in control and MS Sprague-Dawley rat pups at postnatal day 21 (P21)...
October 14, 2017: International Journal of Developmental Neuroscience
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