journal
MENU ▼
Read by QxMD icon Read
search

Trends in Biotechnology

journal
https://www.readbyqxmd.com/read/29310843/rational-design-of-mouse-models-for-cancer-research
#1
REVIEW
Marietta Landgraf, Jacqui A McGovern, Peter Friedl, Dietmar W Hutmacher
The laboratory mouse is widely considered as a valid and affordable model organism to study human disease. Attempts to improve the relevance of murine models for the investigation of human pathologies led to the development of various genetically engineered, xenograft and humanized mouse models. Nevertheless, most preclinical studies in mice suffer from insufficient predictive value when compared with cancer biology and therapy response of human patients. We propose an innovative strategy to improve the predictive power of preclinical cancer models...
January 5, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29310842/a-regulatory-perspective-on-testing-of-biological-activity-of-complex-biologics
#2
Marianne Saldanha, Prajakta Dandekar, Ratnesh Jain
Antibody-drug conjugates (ADCs) and bispecific antibodies are becoming increasingly popular. However, their complex structures mandate stringent regulatory guidelines to ensure their safety and efficacy. We have briefly reviewed the existing regulatory guidelines and presented our perspectives on refining them to hasten the transition of these drugs from laboratories to market.
January 5, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29310841/mixing-seawater-with-a-little-wastewater-to-produce-bioenergy-from-limnetic-algae
#3
Haiyan Pei, Liqun Jiang
Microalgae are considered to be a promising feedstock for biofuel, but expansion of algal lipid production commercially still has a long way to go. Inexhaustible seawater, with a little wastewater added, has great potential to optimize microalga production so that biodiesel production can thrive cost-effectively and sustainably.
January 5, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29310840/biotechnology-patenting-in-the-brics-countries-strategies-and-dynamics
#4
Ekaterina Streltsova, Jonathan D Linton
The BRICS countries (Brazil, Russia, India, China, South Africa) account for 25% of global biotechnology patents. To understand the current and future landscape of the domain, it is important to better understand the capacity of these contributors. Here, we consider the thematic priorities, strategies, and key players of the BRICS countries in biotechnology patenting.
January 5, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29305085/engineering-the-delivery-system-for-crispr-based-genome-editing
#5
REVIEW
Zachary Glass, Matthew Lee, Yamin Li, Qiaobing Xu
Clustered regularly interspaced short palindromic repeat-CRISPR-associated protein (CRISPR-Cas) systems, found in nature as microbial adaptive immune systems, have been repurposed into an important tool in biological engineering and genome editing, providing a programmable platform for precision gene targeting. These tools have immense promise as therapeutics that could potentially correct disease-causing mutations. However, CRISPR-Cas gene editing components must be transported directly to the nucleus of targeted cells to exert a therapeutic effect...
January 2, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29254737/augmenting-research-education-and-outreach-with-client-side-web-programming
#6
Luciano A Abriata, João P G L M Rodrigues, Marcel Salathé, Luc Patiny
The evolution of computing and web technologies over the past decade has enabled the development of fully fledged scientific applications that run directly on web browsers. Powered by JavaScript, the lingua franca of web programming, these 'web apps' are starting to revolutionize and democratize scientific research, education, and outreach.
December 15, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29246477/protein-based-therapeutic-killing-for-cancer-therapies
#7
REVIEW
Naroa Serna, Laura Sánchez-García, Ugutz Unzueta, Raquel Díaz, Esther Vázquez, Ramón Mangues, Antonio Villaverde
The treatment of some high-incidence human diseases is based on therapeutic cell killing. In cancer this is mainly achieved by chemical drugs that are systemically administered to reach effective toxic doses. As an innovative alternative, cytotoxic proteins identified in nature can be adapted as precise therapeutic agents. For example, individual toxins and venom components, proapoptotic factors, and antimicrobial peptides from bacteria, animals, plants, and humans have been engineered as highly potent drugs...
December 12, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29242004/point-of-care-devices-using-disease-biomarkers-to-diagnose-neurodegenerative-disorders
#8
REVIEW
Ting-Yen Wei, Yun Fu, Kuo-Hsuan Chang, Kun-Ju Lin, Yu-Jen Lu, Chao-Min Cheng
Neurodegenerative disorders such as Alzheimer's, Parkinson's, and Huntington's diseases are highly prevalent and immensely destructive to the health and well-being of individuals and their families across the globe. Neurodegenerative diseases are characterized by the gradual loss of neural tissue in the central nervous system. Clearly, early diagnosis of the onset of neurodegeneration is vital and beneficial. Current diagnostic methods rely heavily on symptoms or autopsy results, thus overlooking early diagnosis, the only opportunity for amelioration...
December 11, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29229492/programming-morphogenesis-through-systems-and-synthetic-biology
#9
REVIEW
Jeremy J Velazquez, Emily Su, Patrick Cahan, Mo R Ebrahimkhani
Mammalian tissue development is an intricate, spatiotemporal process of self-organization that emerges from gene regulatory networks of differentiating stem cells. A major goal in stem cell biology is to gain a sufficient understanding of gene regulatory networks and cell-cell interactions to enable the reliable and robust engineering of morphogenesis. Here, we review advances in synthetic biology, single cell genomics, and multiscale modeling, which, when synthesized, provide a framework to achieve the ambitious goal of programming morphogenesis in complex tissues and organoids...
December 8, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29224718/bionic-manufacturing-towards-cyborg-cells-and-sentient-microbots
#10
Sarvesh Kumar Srivastava, Vikramaditya G Yadav
Bio-inspired engineering applies biological design principles towards developing engineering solutions but is not practical as a manufacturing paradigm. We advocate 'bionic manufacturing', a synergistic fusion of biotic and abiotic components, to transition away from bio-inspiration toward bio-augmentation to address current limitations in bio-inspired manufacturing.
December 7, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29329724/the-potential-of-cold-plasma-for-safe-and-sustainable-food-production
#11
REVIEW
Paula Bourke, Dana Ziuzina, Daniela Boehm, Patrick J Cullen, Kevin Keener
Cold plasma science and technology is increasingly investigated for translation to a plethora of issues in the agriculture and food sectors. The diversity of the mechanisms of action of cold plasma, and the flexibility as a standalone technology or one that can integrate with other technologies, provide a rich resource for driving innovative solutions. The emerging understanding of the longer-term role of cold plasma reactive species and follow-on effects across a range of systems will suggest how cold plasma may be optimally applied to biological systems in the agricultural and food sectors...
November 30, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29198980/applications-of-phlip-technology-for-cancer-imaging-and-therapy-trends-in-biotechnology-35-653-664-2017
#12
Linden C Wyatt, Jason S Lewis, Oleg A Andreev, Yana K Reshetnyak, Donald M Engelman
No abstract text is available yet for this article.
November 30, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29196057/organic-electronics-for-point-of-care-metabolite-monitoring
#13
REVIEW
Anna-Maria Pappa, Onur Parlak, Gaetan Scheiblin, Pascal Mailley, Alberto Salleo, Roisin M Owens
In this review we focus on demonstrating how organic electronic materials can solve key problems in biosensing thanks to their unique material properties and implementation in innovative device configurations. We highlight specific examples where these materials solve multiple issues related to complex sensing environments, and we benchmark these examples by comparing them to state-of-the-art commercially available sensing using alternative technologies. We have categorized our examples by sample type, focusing on sensing from body fluids in vitro and on wearable sensors, which have attracted significant interest owing to their integration with everyday life activities...
November 28, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29174176/communicating-biotech-advances-fiction-versus-reality
#14
Aleksandra Małyska, Robert Bolla, Tomasz Twardowski
Bioscience novels use selected technologies of genetic engineering and synthetic biology to create entertaining stories. These novels are usually based on scientific knowledge, but they may arouse public concerns about technology and drive public reluctance to accept innovative technologies. The scientific community must adopt more efficient communication and transparency.
November 22, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29157536/a-comparison-of-techniques-to-evaluate-the-effectiveness-of-genome-editing
#15
REVIEW
Diego Germini, Tatiana Tsfasman, Vlada V Zakharova, Nikolajs Sjakste, Marс Lipinski, Yegor Vassetzky
Genome editing using engineered nucleases (meganucleases, zinc finger nucleases, transcription activator-like effector nucleases) has created many recent breakthroughs. Prescreening for efficiency and specificity is a critical step prior to using any newly designed genome editing tool for experimental purposes. The current standard screening methods of evaluation are based on DNA sequencing or use mismatch-sensitive endonucleases. They can be time-consuming and costly or lack reproducibility. Here, we review and critically compare standard techniques with those more recently developed in terms of reliability, time, cost, and ease of use...
November 17, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29157535/crispr-based-antibacterials-transforming-bacterial-defense-into-offense
#16
Adrienne C Greene
The development of antimicrobial-resistant (AMR) bacteria poses a serious worldwide health concern. CRISPR-based antibacterials are a novel and adaptable method for building an arsenal of antibacterials potentially capable of targeting any pathogenic bacteria.
November 17, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29153346/gravity-tissue-engineering-and-the-missing-link
#17
Raquel Costa-Almeida, Pedro L Granja, Manuela E Gomes
The influence of microgravity and hypergravity on living systems has attracted significant attention, but the use of these tools in tissue engineering (TE) remains relatively unexplored. This Forum article highlights an emerging field of research to uncover new potential applications at the interface between altered gravity and TE.
November 16, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29153762/basic-and-clinical-approaches-for-fertility-preservation-and-restoration-in-cancer-patients
#18
REVIEW
Jose V Medrano, María Del Mar Andrés, Sofía García, Sonia Herraiz, Teresa Vilanova-Pérez, Ellen Goossens, Antonio Pellicer
As gonadotoxic adverse effects of antineoplastic treatments can result in infertility, gamete cryopreservation is routinely offered to patients as the strategy to preserve their fertility. However, there are many cases where gold standards cannot be applied, as is the case for prepubertal cancer patients and others unable to produce gametes or their precursors at the moment of diagnosis. With an increasing number of cancer survivors in our society, strategies using either cryopreserved gonadal tissue or stem cells have been developed to allow cancer survivors to achieve fatherhood, and recent advances in the field have increased public interest...
November 15, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29224719/cyberbiosecurity-from-naive-trust-to-risk-awareness
#19
Jean Peccoud, Jenna E Gallegos, Randall Murch, Wallace G Buchholz, Sanjay Raman
The cyber-physical nature of biotechnology raises unprecedented security concerns. Computers can be compromised by encoding malware in DNA sequences, and biological threats can be synthesized using publicly available data. Trust within the biotechnology community creates vulnerabilities at the interface between cyberspace and biology. Awareness is a prerequisite to managing these risks.
November 14, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29150381/a-plea-for-the-renewal-of-the-isbr
#20
Giovanni Tagliabue, Marcel Kuntz, Henry I Miller, Klaus Ammann
The recent meeting of the International Society for Biosafety Research (ISBR) focused on so-called genetically modified organisms. For decades, in most regulatory frameworks, recombinant DNA-modified organisms have been the wrong focus of unbalanced agri-food regulations. The ISBR should instead adopt a scientifically defensible and truly risk-based perspective, abandoning a misleading pseudo-category.
November 14, 2017: Trends in Biotechnology
journal
journal
28692
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"