journal
MENU ▼
Read by QxMD icon Read
search

Trends in Biotechnology

journal
https://www.readbyqxmd.com/read/28818304/organic-nanoparticle-based-combinatory-approaches-for-gene-therapy
#1
LETTER
Brahma N Singh, Prateeksha, Vijai K Gupta, Jieyin Chen, Atanas G Atanasov
Engineered organic nanoparticle (ONP)-mediated co-delivery of genes and therapeutic agents is emerging as a powerful tool in the treatment of several genetic and non-genetic disorders. The ONP-based combinatory approach provides a technological platform that delivers genes with chemo/radio/photo/immunotherapies for the prevention or treatment of disease progression.
August 14, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28789815/bioprinting-and-cellular-therapies-for-type-1-diabetes
#2
REVIEW
Dino J Ravnic, Ashley N Leberfinger, Ibrahim T Ozbolat
Type 1 diabetes mellitus is a chronic autoimmune disease that results from the destruction of beta (β) cells in the pancreatic islets, leading to loss of insulin production and resultant hyperglycemia. Recent developments in stem cell biology have generated much excitement for β-cell replacement strategies; β cells are one of many cell types in the complex islet environment and pancreas. In this Opinion, we discuss recent successful attempts to generate β cells and how this can be coupled with bioprinting technologies in order to fabricate pancreas tissues, which holds great potential for type 1 diabetes...
August 5, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28778607/the-business-of-anti-aging-science
#3
REVIEW
João Pedro de Magalhães, Michael Stevens, Daniel Thornton
Age-related conditions are the leading causes of death and health-care costs. Reducing the rate of aging would have enormous medical and financial benefits. Myriad genes and pathways are known to regulate aging in model organisms, fostering a new crop of anti-aging companies. Approaches range from drug discovery efforts to big-data methods and direct-to-consumer (DTC) strategies. Challenges and pitfalls of commercialization include reliance on findings from short-lived model organisms, poor biological understanding of aging, and hurdles in performing clinical trials for aging...
August 1, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28778606/advances-in-industrial-biotechnology-using-crispr-cas-systems
#4
REVIEW
Paul D Donohoue, Rodolphe Barrangou, Andrew P May
The term 'clustered regularly interspaced short palindromic repeats' (CRISPR) has recently become synonymous with the genome-editing revolution. The RNA-guided endonuclease CRISPR-associated protein 9 (Cas9), in particular, has attracted attention for its promise in basic research and gene editing-based therapeutics. CRISPR-Cas systems are efficient and easily programmable nucleic acid-targeting tools, with uses reaching beyond research and therapeutic development into the precision breeding of plants and animals and the engineering of industrial microbes...
August 1, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28760478/engaging-the-senses-understanding-publics-research-methods-science-engagement-and-synthetic-biology
#5
Robert Meckin, Andrew Balmer
Scientists and government actors often fear a 'public rejection' of biotechnology, especially regarding genetic modification. Through a research project aimed at engaging people's senses, we support an alternative way for scientists to consider non-scientists in their research.
July 28, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28755977/plasmas-for-treating-cancer-opportunities-for-adaptive-and-self-adaptive-approaches
#6
REVIEW
Michael Keidar, Dayun Yan, Isak I Beilis, Barry Trink, Jonathan H Sherman
Plasma is an ionized gas that is typically formed under high-temperature laboratory conditions. Recent progress in atmospheric plasmas has led to cold atmospheric plasma (CAP) devices with ion temperatures close to room temperature. The unique chemical and physical properties of CAP have led to its use in various biomedical applications including cancer therapy. CAP exhibits a spontaneous transition from a spatially homogeneous state to a modifiable pattern that is subject to self-organization. In this Opinion article, we discuss some new applications for plasma in cancer therapy based on plasma self-organization, which enables adaptive features in plasma-based therapeutic systems...
July 26, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28755976/g-quadruplexes-prediction-characterization-and-biological-application
#7
REVIEW
Chun Kit Kwok, Catherine J Merrick
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention for decades. Recent methodological advances have advanced the identification and characterization of G-quadruplexes in vivo as well as in vitro, and at a much higher resolution and throughput, which has greatly expanded our current understanding of G-quadruplex structure and function...
July 26, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28755975/microfluidic-mass-spectrometry-interfaces-for-translational-proteomics
#8
REVIEW
R Daniel Pedde, Huiyan Li, Christoph H Borchers, Mohsen Akbari
Interfacing mass spectrometry (MS) with microfluidic chips (μchip-MS) holds considerable potential to transform a clinician's toolbox, providing translatable methods for the early detection, diagnosis, monitoring, and treatment of noncommunicable diseases by streamlining and integrating laborious sample preparation workflows on high-throughput, user-friendly platforms. Overcoming the limitations of competitive immunoassays - currently the gold standard in clinical proteomics - μchip-MS can provide unprecedented access to complex proteomic assays having high sensitivity and specificity, but without the labor, costs, and complexities associated with conventional MS sample processing...
July 26, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28751147/stem-cell-therapies-for-reversing-vision-loss
#9
REVIEW
Akon Higuchi, S Suresh Kumar, Giovanni Benelli, Abdullah A Alarfaj, Murugan A Munusamy, Akihiko Umezawa, Kadarkarai Murugan
Current clinical trials that evaluate human pluripotent stem cell (hPSC)-based therapies predominantly target treating macular degeneration of the eyes because the eye is an isolated tissue that is naturally weakly immunogenic. Here, we discuss current bioengineering approaches and biomaterial usage in combination with stem cell therapy for macular degeneration disease treatment. Retinal pigment epithelium (RPE) differentiated from hPSCs is typically used in most clinical trials for treating patients, whereas bone marrow mononuclear cells (BMNCs) or mesenchymal stem cells (MSCs) are intravitreally transplanted, undifferentiated, into patient eyes...
July 24, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28751146/ethnophytotechnology-harnessing-the-power-of-ethnobotany-with-biotechnology
#10
John de la Parra, Cassandra L Quave
Ethnobotany (the scientific study of traditional plant knowledge) has aided the discovery of important medicines. However, as single-molecule drugs or synergistic mixtures, these remedies have faced obstacles in production and analysis. Now, advances in bioreactor technology, metabolic engineering, and analytical instrumentation are improving the production, manipulation, and scientific understanding of such remedies.
July 24, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28739221/structure-and-computation-in-immunoreagent-design-from-diagnostics-to-vaccines
#11
REVIEW
Louise Gourlay, Claudio Peri, Martino Bolognesi, Giorgio Colombo
Novel immunological tools for efficient diagnosis and treatment of emerging infections are urgently required. Advances in the diagnostic and vaccine development fields are continuously progressing, with reverse vaccinology and structural vaccinology (SV) methods for antigen identification and structure-based antigen (re)design playing increasingly relevant roles. SV, in particular, is predicted to be the front-runner in the future development of diagnostics and vaccines targeting challenging diseases such as AIDS and cancer...
July 21, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28739220/beyond-native-cas9-manipulating-genomic-information-and-function
#12
REVIEW
Hitoshi Mitsunobu, Jun Teramoto, Keiji Nishida, Akihiko Kondo
Clustered regularly interspaced short palindromic repeats (CRISPR)-mediated manipulation of genomic information is becoming more versatile by combining nuclease-deficient CRISPR systems with a wide variety of effectors including base-editing deaminases, transcriptional regulators, and epigenetic modifiers. The programmable binding ability of CRISPR systems is essential when the systems are employed as targeting domains to recruit the effectors to specific genomic loci. The discovery of a variety of Cas9 orthologs and engineered variants enables high-fidelity genome editing and a wider selection of genomic targets, and CRISPR-mediated deaminases enable more precise and predictable genome editing compared with CRISPR nuclease-based editing...
July 21, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28736087/sphingomonads-in-microbe-assisted-phytoremediation-tackling-soil-pollution
#13
REVIEW
Michael Gatheru Waigi, Kai Sun, Yanzheng Gao
Soil pollution has become a major concern in various terrestrial ecosystems worldwide. One in situ soil bioremediation strategy that has gained popularity recently is microbe-assisted phytoremediation, which is promising for remediating pollutants. Sphingomonads, a versatile bacteria group comprising four well-known genera, are ubiquitous in vegetation grown in contaminated soils. These Gram-negative microbes have been investigated for their ability to induce innate plant growth-promoting (PGP) traits, including the formation of phytohormones, siderophores, and chelators, in addition to their evolutionary adaptations enabling biodegradation and microbe-assisted removal of contaminants...
July 20, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28734545/engineered-hydrogels-in-cancer-therapy-and-diagnosis
#14
REVIEW
Mohammadmajid Sepantafar, Reihan Maheronnaghsh, Hossein Mohammadi, Fatemeh Radmanesh, Mohammad Mahdi Hasani-Sadrabadi, Marzieh Ebrahimi, Hossein Baharvand
Over the last decade, numerous investigations have attempted to clarify the intricacies of tumor development to propose effective approaches for cancer treatment. Thanks to the unique properties of hydrogels, researchers have made significant progress in tumor model reconstruction, tumor diagnosis, and associated therapies. Notably, hydrogel-based systems can be adjusted to respond to cancer-specific hallmarks and/or external stimuli. These well-known drug reservoirs can be used as smart carriers for multiple cargos, including both naked and nanoparticle-encapsulated chemotherapeutics, genes, and radioisotopes...
July 19, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28733078/respiratory-protection-against-pandemic-and-epidemic-diseases
#15
Ilaria Rubino, Hyo-Jick Choi
Respiratory protection against airborne pathogens is crucial for pandemic/epidemic preparedness in the context of personal protection, healthcare systems, and governance. We expect that the development of technologies that overcome the existing challenges in current respiratory protective devices will lead to a timely and effective response to the next outbreak.
July 18, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28720284/modeling-of-plasmas-for-biomedicine
#16
REVIEW
Natalia Yu Babaeva, George V Naidis
Studies in plasma medicine, which are currently actively expanding, are of multidisciplinary character, involving physical, chemical and biological processes. Rapid progress has been achieved in this field due to synergy between experimental and theoretical/computational methods. Joint use of diagnostic tools and computations gives a better understanding of mechanisms of interaction of plasma with bio-objects. This review focuses on recent achievements in modeling of plasma for biomedical applications. Various computational approaches used in these studies are described...
July 15, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28720283/addressing-the-digital-divide-in-contemporary-biology-lessons-from-teaching-unix
#17
Serghei Mangul, Lana S Martin, Alexander Hoffmann, Matteo Pellegrini, Eleazar Eskin
Life and medical science researchers increasingly rely on applications that lack a graphical interface. Scientists who are not trained in computer science face an enormous challenge analyzing high-throughput data. We present a training model for use of command-line tools when the learner has little to no prior knowledge of UNIX.
July 15, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28711155/manufacturing-cell-therapies-using-engineered-biomaterials
#18
REVIEW
Amr A Abdeen, Krishanu Saha
Emerging manufacturing processes to generate regenerative advanced therapies can involve extensive genomic and/or epigenomic manipulation of autologous or allogeneic cells. These cell engineering processes need to be carefully controlled and standardized to maximize safety and efficacy in clinical trials. Engineered biomaterials with smart and tunable properties offer an intriguing tool to provide or deliver cues to retain stemness, direct differentiation, promote reprogramming, manipulate the genome, or select functional phenotypes...
July 12, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28693858/plasma-in-dentistry-brief-history-and-current-status
#19
Matteo Gherardi, Riccardo Tonini, Vittorio Colombo
We briefly discuss the history of cold atmospheric plasma (CAP) applications in dentistry. The reasons for seeking innovative solutions in dentistry are reported, highlighting results showing the potential of plasma along with some still-open questions. Finally, we suggest the next steps on the road from the laboratory to the dental chair.
July 7, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28666545/biotechnological-perspectives-of-pyrolysis-oil-for-a-bio-based-economy
#20
REVIEW
Stefanie Arnold, Karin Moss, Marius Henkel, Rudolf Hausmann
Lignocellulosic biomass is an important feedstock for a potential future bio-based economy. Owing to its compact structure, suitable decomposition technologies will be necessary to make it accessible for biotechnological conversion. While chemical and enzymatic hydrolysis are currently established methods, a promising alternative is provided by fast pyrolysis. The main resulting product thereof, referred to as pyrolysis oil, is an energy-rich and easily transportable liquid. Many of the identified constituents of pyrolysis oil, however, have previously been reported to display adverse effects on microbial growth...
June 27, 2017: Trends in Biotechnology
journal
journal
28692
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"