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Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism

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https://www.readbyqxmd.com/read/28854709/melatonin-restores-white-blood-cell-count-diminishes-glycated-haemoglobin-level-and-prevents-liver-kidney-and-muscle-oxidative-stress-in-mice-exposed-to-acute-ethanol-intoxication
#1
Natalia Kurhaluk, Alina Sliuta, Svitlana Kyriienko, Pawel J Winklewski
Aims: The aim of the study was to examine the effects of melatonin impact on changes in haematological profile, biomarkers of oxidative stress (dienes conjugates, malondialdehyde (MDA), oxidatively modified protein levels, total antioxidant capacity and antioxidant enzyme activity) in liver, muscle, kidney and erythrocytes, and glycated haemoglobin (HBA1c) in mice during acute ethanol stress. Methods: Assays were carried out in quadruplicate: control, melatonin (10 mg/kg, 10 days), acute ethanol stress (0...
September 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28854708/rapidly-increasing-trend-of-recorded-alcohol-consumption-since-the-end-of-the-armed-conflict-in-sri-lanka
#2
Manjula D Nugawela, Sarah Lewis, Lisa Szatkowski, Tessa Langley
Aim: To evaluate temporal changes in recorded alcohol consumption in Sri Lanka during and after the armed conflict 1998-2013. Methods: District level alcohol sales, and mid-year population data for the whole study period (1998-2013) were consistently available from the Department of Excise and the Department of Census and Statistics for 18 of 25 districts. These data were used to estimate the recorded per capita consumption for the areas that were not directly exposed to the armed conflict...
September 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28854707/changes-in-pro-inflammatory-markers-in-detoxifying-chronic-alcohol-abusers-divided-by-lesch-typology-reflect-cognitive-dysfunction
#3
Catherine Hanak, Janaina Benoit, Lauriane Fabry, Matthieu Hein, Paul Verbanck, Philippe de Witte, Henriette Walter, David T Dexter, Roberta J Ward
Aim: To investigate pro-inflammatory markers in the blood and associate with cognitive impairment. Methods: Il-6 and ferritin were assayed in the blood of 27 patients, divided according to Lesch typology, at the commencement and after 21 days of detoxification, together with a battery of cognitive tests. Results: A significantly higher mean level of IL-6 was present in the blood of patients with Lesch typology 1 compared to the other typologies 2 and 3 on admission to the Detoxification Ward which did not alter significantly after detoxification...
September 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28655148/genetic-variants-in-the-manganese-superoxide-dismutase-2-gene-and-in-the-catalase-gene-are-not-associated-with-alcoholic-chronic-pancreatitis
#4
Alexander Schneider, Jonas Rosendahl, Peter Bugert, Christel Weiss, Heike Unterschütz, Marja-Leena Kylanpää-Bäck, Marko Lempinen, Esko Kemppainen, Brindusa L Diaconu, Matthias P Ebert, Roland H Pfützer
Aims: Oxidative stress may contribute to the development of chronic pancreatitis (CP). The enzymes manganese superoxide dismutase 2 (MnSOD, SOD2) and catalase (CAT) counteract free radical activity within the mitochondria and the cytosol. Moreover, CAT activity contributes to the transformation of ethanol to acetaldehyde, a toxic intermediate product of ethanol metabolism, which has been associated with pancreatic damage. Common functional polymorphisms have been described in the MnSOD gene [rs4880, NM_000636...
September 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28651327/alpha-klotho-and-fibroblast-growth-factor-23-among-alcoholics
#5
Geraldine Quintero-Platt, Emilio González-Reimers, Melchor Rodríguez-Gaspar, Candelaria Martín-González, Onán Pérez-Hernández, Lucía Romero-Acevedo, Elisa Espelosín-Ortega, María José de la Vega-Prieto, Francisco Santolaria-Fernández
Aims: Alcoholism may be a cardiovascular risk factor. Osteocyte derived molecules such as fibroblast growth factor 23 (FGF-23) and soluble α Klotho have recently been associated with cardiovascular disease, but their role in alcoholics is unknown. We here analyze the behavior of FGF23 and α Klotho in alcoholics. Methods: Ninety-seven alcoholic patients were assessed for liver function, presence of hypertension, diabetes, atrial fibrillation, left ventricular hypertrophy (LVH), vascular calcifications (assessed by chest X-ray) and nutritional status (lean and fat mass measured by densitometry)...
September 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28637313/trajectories-of-alcohol-use-disorders-and-their-differential-impact-a-population-based-cohort-study-in-goa-india
#6
Abhijit Nadkarni, Helen A Weiss, Bhargav Bhat, Vikram Patel
Aims: The aim of this study was to examine trajectories of Alcohol Use Disorders (AUD) over a 6 year period and compare the bio-psycho-social correlates between these trajectories. Methods: Community-based cohort of 1899 adult men were interviewed in 2006-2008 and 2012-2014. AUD were assessed using the Alcohol Use Disorder Identification Test, and potential correlates including psycho-social problems, morbidity and physiological parameters were measured at follow-up...
September 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28633437/corrigendum-barriers-to-alcohol-screening-among-hypertensive-patients-and-the-role-of-stigma-lessons-for-the-implementation-of-screening-and-brief-interventions-in-european-primary-care-settings
#7
Franz Hanschmidt, Jakob Manthey, Ludwig Kraus, Emanuele Scafato, Antoni Gual, Carsten Grimm, Jürgen Rehm
No abstract text is available yet for this article.
September 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28633431/differential-effects-of-alcohol-on-memory-performance-in-adolescent-men-and-women-with-a-binge-drinking-history
#8
Concepción Vinader-Caerols, Andrew Talk, Adriana Montañés, Aránzazu Duque, Santiago Monleón
Aims: Binge drinking (BD) is characterized by intermittent consumption of large quantities of alcohol in short periods. This pattern of drinking is prevalent among adolescents, and has been associated with undermined learning and memory ability. This study investigates the relationships between a history of BD and the effects of acute exposure to alcohol on learning and memory performance in adolescent men and women. Methods: A high, acute dose of alcohol or control refreshment was administered to a sample of 172 adolescent undergraduate students, some of which had a history of BD and others of which had refrained from alcohol consumption...
September 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28633363/development-initial-testing-and-challenges-of-an-ecologically-valid-reward-prediction-error-fmri-task-for-alcoholism
#9
Anita Cservenka, Kelly E Courtney, Dara G Ghahremani, Kent E Hutchison, Lara A Ray
Aims: To advance translational studies of the role of reward prediction error (PE) in alcohol use disorder, the present study sought to develop and conduct an initial test of an alcohol-specific PE task paradigm using functional magnetic resonance imaging in humans. Methods: Alcohol dependent or social drinkers received small tastes of their preferred alcohol beverage or control beverage, with preceding visual cues indicating whether alcohol (or water) would be delivered...
September 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28591801/systematic-review-of-guidelines-on-managing-patients-with-harmful-use-of-alcohol-in-primary-healthcare-settings
#10
De-Xing Zhang, Shannon Tsz-Shan Li, Queenie Kwan-Yee Lee, Koey Hoi-Shuen Chan, Jean Hee Kim, Benjamin Hon-Kei Yip, Roger Yat-Nork Chung, Alvin Ho-Cheuk Wong, Yuan Fang, Miaoyin Liang, Martin Chi-Sang Wong
Aim: To appraise existing alcohol guidelines for identifying and managing harmful alcohol use in primary healthcare settings. Methods: Seven databases and 18 health organization or medical society websites were systematically searched from inception to 31 October 2016. Guidelines in English language, developed by a national or international medical specialty society, government or health organization, and containing recommendations for identifying and managing harmful use of alcohol in primary healthcare settings, were included...
September 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28591773/ethyl-glucuronide-elimination-kinetics-in-fingernails-and-comparison-to-levels-in-hair
#11
Jan Toralf Fosen, Luca Morini, Cristina Sempio, Nefele Giarratana, Asle Enger, Jørg Mørland, Gudrun Høiseth
Aims: Measurement of ethyl glucuronide (EtG) in nail, as a biomarker for alcohol intake, has recently been suggested as alternative to measurement in hair. The aim of this study was to compare levels of EtG in nail and hair, and to investigate the elimination kinetics of EtG in fingernails during an alcohol abstinent period. Methods: Overall, 40 subjects (median estimated daily intake of ethanol (EDI) 92.5 g/day) were recruited from an alcohol rehabilitation clinic...
September 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28591763/non-linear-formation-of-etg-and-faees-after-controlled-administration-of-low-to-moderate-doses-of-ethanol
#12
Clara Pérez-Mañá, Magí Farré, Antoni Pastor, Francina Fonseca, Marta Torrens, Esther Menoyo, Mitona Pujadas, Silvia Frias, Klaus Langohr, Rafael de la Torre
Aims: Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) are non-oxidative metabolites of alcohol that can be detected in conventional and non-conventional biological matrices for longer periods than alcohol. The aim was to describe the time courses of both biomarkers after ingestion of acute low-moderate doses of ethanol. Methods: The study design was double-blind, randomized, crossover and controlled with placebo. Participants were distributed in three different cohorts: (a) Cohort-1: two doses of 18 and 30 g of ethanol and placebo were administered to 12 subjects; (b) Cohort-2: two doses of 6 and 12 g of ethanol and placebo were administered to six subjects and (c) Cohort-3: two doses of 24 and 42 g of ethanol and placebo were administered to six subjects...
September 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28582511/a-note-on-the-statistical-power-of-regression-analysis
#13
Kari Poikolainen
No abstract text is available yet for this article.
September 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28541449/barriers-to-alcohol-screening-among-hypertensive-patients-and-the-role-of-stigma-lessons-for-the-implementation-of-screening-and-brief-interventions-in-european-primary-care-settings
#14
Franz Hanschmidt, Jakob Manthey, Ludwig Kraus, Emanuele Scafato, Antoni Gual, Carsten Grimm, Jürgen Rehm
Aims: 1. To quantify barriers to alcohol screening among hypertensive patients reported by primary healthcare professionals. 2. To examine whether education and screening frequency measures are associated with stigma-related barriers. Methods: A web survey was conducted among 3081 primary healthcare professionals from France, Germany, Italy, Spain and the UK. Participants were asked about perceived barriers to alcohol screening as free-text response. The replies were independently categorized by two raters...
September 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28481972/age-of-onset-current-use-of-alcohol-tobacco-or-marijuana-and-current-polysubstance-use-among-male-and-female-mexican-students
#15
Lee Strunin, Alejandro Díaz-Martínez, L Rosa Díaz-Martínez, Timothy Heeren, Clara Chen, Michael Winter, Seth Kuranz, Carlos A Hernández-Ávila, Héctor Fernández-Varela, Cuauhtémoc Solís-Torres
Aims: This study aimed to examine alcohol, tobacco or marijuana use onset and associations between age of onset and current use, and between age of onset and current polysubstance use among a sample of Mexican young people aged 17-20 years. Methods: Alcohol, tobacco, marijuana and other substance use were identified in a 2012 cross-sectional survey of male and female students entering first year university in Mexico City. Chi-square tests and logistic regression models examined associations between gender, age of onset, order of onset, family substance use and current polysubstance use among 22,224 students...
September 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28525555/a-randomized-placebo-controlled-study-of-high-dose-baclofen-in-alcohol-dependent-patients-the-alpadir-study
#16
Michel Reynaud, Henri-Jean Aubin, Francoise Trinquet, Benjamin Zakine, Corinne Dano, Maurice Dematteis, Benoit Trojak, Francois Paille, Michel Detilleux
Aims: Alcohol dependence is a major public health issue with a need for new pharmacological treatments. The ALPADIR study assessed the efficacy and safety of baclofen at the target dose of 180 mg/day for the maintenance of abstinence and the reduction in alcohol consumption in alcohol-dependent patients. Methods: Three hundred and twenty adult patients (158 baclofen and 162 placebo) were randomized after alcohol detoxification. After a 7-week titration, the maintenance dose was provided for 17 weeks, then progressively decreased over 2 weeks before stopping...
July 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28525540/alcohol-consumption-and-common-carotid-intima-media-thickness-the-use-imt-study
#17
Annie R Britton, Diederick E Grobbee, Hester M den Ruijter, Todd J Anderson, Moise Desvarieux, Gunnar Engström, Greg W Evans, Bo Hedblad, Jussi Kauhanen, Sudhir Kurl, Eva M Lonn, Ellisiv B Mathiesen, Joseph F Polak, Jacqueline F Price, Christopher M Rembold, Maria Rosvall, Tatjana Rundek, Jukka T Salonen, Coen Stehouwer, Tomi-Pekka Tuomainen, Michiel L Bots
Aims: Epidemiological evidence indicates a protective effect of light to moderate alcohol consumption compared to non-drinking and heavy drinking. Although several mechanisms have been suggested, the effect of alcohol on atherosclerotic changes in vessel walls is unclear. Therefore, we explored the relationship between alcohol consumption and common carotid intima media thickness, a marker of early atherosclerosis in the general population. Methods: Individual participant data from eight cohorts, involving 37,494 individuals from the USE-IMT collaboration were used...
July 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28525537/the-influence-of-smoking-and-smokeless-tobacco-on-the-progression-severity-and-treatment-outcome-in-alcohol-dependent-individuals
#18
Kerstin K Rauwolf, Kristina J Berglund, Ulf Berggren, Jan Balldin, Claudia Fahlke
Aims: The influence of tobacco use in alcohol-dependent individuals is not well understood, especially the role of snuffing, which is common in Northern Europe. The aim was therefore to investigate the influence of smoking and snuffing on the progression, severity and treatment outcome in alcohol-dependent individuals. The hypotheses were that concomitant tobacco use (i.e. smoking or snuffing) would enhance the progression and severity of alcohol dependence and be less beneficial for treatment outcome, relative to tobacco non-users...
July 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28498886/risky-drinkers-underestimate-their-own-alcohol-consumption
#19
Antoni Gual, José Ángel Arbesú, José Zarco, María de Las Mercedes Balcells-Oliveró, Hugo López-Pelayo, Laia Miquel, Julio Bobes
No abstract text is available yet for this article.
July 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28482064/gut-liver-axis-and-sterile-signals-in-the-development-of-alcoholic-liver-disease
#20
Gyongyi Szabo, Jan Petrasek
Background: Innate immunity plays a critical role in the development of alcohol-induced liver inflammation. Understanding the inter-relationship of signals from within and outside of the liver that trigger liver inflammation is pivotal for development of novel therapeutic targets of alcoholic liver disease (ALD). Aim: The aim of this paper is to review recent advances in the field of alcohol-induced liver inflammation. Methods: A detailed literature review was performed using the PubMed database published between January 1980 and December 2016...
July 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
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