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Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism

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https://www.readbyqxmd.com/read/30020409/can-the-impact-of-topiramate-on-memory-processes-be-related-to-its-antialcoholic-activity-a-preclinical-study
#1
Ewa Zwierzynska, Agata Krupa-Burtnik, Agnieszka Wiesner, Boguslawa Pietrzak
Aims: Topiramate causes the inhibition of alcohol consumption in addicts but the mechanism of this action has not been fully understood yet. Nowadays, it seems that memory may have a role in the development of dependence. In this study, the impact of topiramate and ethanol on the bioelectric activity of the brain in rabbits and on spatial memory in rats was evaluated. Short summary: The aim of the study was to assess the effect of co-administration of topiramate and ethanol on bioelectric activity of the rabbits' brain and on spatial memory in rats...
July 18, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/30020398/p3-component-as-a-potential-endophenotype-for-control-inhibition-in-offspring-of-alcoholics
#2
Domínguez-Centeno I, R Jurado-Barba, A Sion, A Martinez-Maldonado, G Castillo-Parra, F López-Muñoz, G Rubio, Martinez-Gras I
Aims: To assess inhibitory processes and the ongoing event-related potential (ERP) activity of offspring of alcoholics (OA) during a Go/No-Go task, with the purpose of characterizing possible psychophysiological endophenotypes for alcohol-dependent vulnerability. Short summary: EEG recordings and ERP measurements of young adults with positive and negative family history of alcoholism where obtained while they performed a Go/No-Go task to assess inhibitory processes...
July 18, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/30016385/identifying-and-characterizing-subpopulations-of-heavy-alcohol-drinkers-via-a-sucrose-preference-test-a-sweet-road-to-a-better-phenotypic-characterization
#3
Sofia Bouhlal, Mehdi Farokhnia, Mary R Lee, Fatemeh Akhlaghi, Lorenzo Leggio
Aims: Sweet preference in individuals with alcohol use disorder (AUD) has been associated with family history of AUD and personality traits. Therefore, testing sweet preference may help identify subpopulations of AUD individuals. Short summary: Sweet preference has been associated with family history of AUD and personality traits. We compared heavy drinkers based on their sweet liker status and using two cutoffs. Our findings support the role of sweet preference in heavy drinkers and point to the importance of how sweet likers are defined...
July 17, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/30007323/the-dangerous-pattern-of-concurrent-use-of-alcohol-and-cocaine-among-drunk-drivers-of-northeast-italy
#4
Rossella Snenghi, Guido Pelletti, Anna Chiara Frigo, Giovanni Forza, Alessandro Nalesso, Massimo Montisci, Donata Favretto
Aim: To estimate the prevalence of drug and polydrug use among drunk-drivers during the driving license regranting program, in order to assess the inclusion of toxicological tests on hair and urine samples in the systematic methodology in this category of subjects. Short summary: A total of 2160 drunk-drivers were tested for alcohol and drugs during driving license regranting. Thirty-one subjects showed alcohol use, 212 illicit drug use and, among these, 131 were polydrug users...
July 11, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29982300/maladaptive-schemas-among-people-addicted-to-alcohol-heterogeneity-but-not-specificity
#5
Jan Chodkiewicz, Ewa Gruszczynska
Aims: Early maladaptive schemas described by Young theoretically underlie the development of psychopathology, including substance use. The key assumption is that the schemas do not act in isolation but create configurations that are, at least to a certain extent, distinctive for specific disorders. Thus, the aim of the current study was to examine whether a schema profile specific to alcohol addiction can be identified when compared to profiles obtained from a non-clinical sample. Short Summary: Early maladaptive schemas are cognitive and behavioral patterns related to a wide spectrum of psychopathology, including alcohol addiction...
July 4, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29982285/interactions-between-tlr4-methylation-and-alcohol-consumption-on-subjective-responses-to-an-alcohol-infusion
#6
Hollis C Karoly, Jarrod M Ellingson, Kent E Hutchison
Aims: Converging evidence has implicated perturbed inflammatory signaling in alcohol use disorders (AUDs), and both animal and human studies suggest that alcohol-induced inflammatory signaling is mediated by Toll-Like Receptor 4 (TLR4). We previously demonstrated that TLR4 is hypermethylated in subjects with AUD compared to control individuals. Examining the relationship between TLR4 methylation and subjective alcohol responses could shed light on the role of TLR4 in promoting AUDs, thereby highlighting its potential as a treatment target...
July 4, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29947730/sex-differences-in-the-association-between-heavy-drinking-and-behavioral-distress-tolerance-and-emotional-reactivity-among-non-depressed-college-students
#7
Paola Pedrelli, Laura MacPherson, Amanda J Khan, Benjamin G Shapero, Lauren B Fisher, Maren Nyer, Paolo Cassano, Lindsey Parnarouskis, Amy Farabaugh, Maurizio Fava, Marisa M Silveri
Background: Heavy episodic drinking (HED) is a common behavior among college students that is associated with severe negative consequences. Negative reinforcement processes have been applied to elucidate mechanisms underlying relationships between consumption of alcohol and the desire to alleviate negative feelings. Distress tolerance (DT) and emotional reactivity are two mechanisms that are consistent with the self-medication model that may contribute to HED. The current study investigated relationships between DT, emotional reactivity, defined as frustration reactivity and irritability reactivity, and HED in a non-depressed college population...
June 27, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29931096/association-of-biological-markers-of-alcohol-consumption-and-self-reported-drinking-with-hippocampal-volume-in-a-population-based-sample-of-adults
#8
Andrew Naglich, Erin Van Enkevort, Bryon Adinoff, E Sherwood Brown
Aims: The current study examined a large community cohort to understand relationships between indicators of alcohol consumption and hippocampal volume. Short summary: Alcohol use measures were not associated with hippocampal volume in a population-based sample. However, alcohol consumption was associated with hippocampal volume reduction in subsets of the sample including subjects aged ≥50 years old, and those with none to moderate levels of depressive symptoms...
June 21, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29912275/selective-blockade-of-t-type-ca2-channels-is-protective-against-alcohol-withdrawal-induced-seizure-and-mortality
#9
Melissa L Masicampo, Hong Qu Shan, Victoria Xu, Merritt Speagle, Dwayne W Godwin
Aims: We have previously demonstrated that blockade of T-type calcium channels by the non-selective antagonist, ethosuximide (ETX), is effective at reducing electrographical and behavioral correlates of alcohol-withdrawal (WD) seizure. Here, we investigated whether blockade of these calcium channels with the selective antagonist TTA-P2 also reduces alcohol-WD seizure. Short summary: The non-specific T-type calcium channel antagonist, ETX, is protective against alcohol-WD seizure...
June 15, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29912265/leptin-expression-and-gene-methylation-patterns-in-alcohol-dependent-patients-with-ethyltoxic-cirrhosis-normalization-after-liver-transplantation-and-implications-for-future-research
#10
P J Proskynitopoulos, M Rhein, E Jäckel, M P Manns, H Frieling, S Bleich, T Thum, T Hillemacher, A Glahn
Aims: Liver transplantation is the only curative treatment available for patients with end-stage alcoholic liver disease. As different studies showed a significant association between leptin plasma levels, gene methylation patterns and the extent of craving in alcohol-dependent patients, we investigated the effect of liver transplantation on leptin expression and promoter methylation. Short Summary: The present study shows that in alcohol-dependent patients with liver cirrhosis leptin is significantly higher before liver transplantation and decreases significantly after transplantation...
June 15, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29901690/seeking-help-for-harm-from-others-drinking-in-five-asian-countries-variation-between-societies-by-type-of-harm-and-by-source-of-help
#11
Orratai Waleewong, Anne-Marie Laslett, Richard Chenhall, Robin Room
Aims: This study aims to measure the prevalence rates and patterns of help-seeking behavior as a consequence of being harmed by drinkers in five Asian countries (India, Sri Lanka, Vietnam, Lao PDR and Thailand). Methods: A total of 9832 respondents aged 18-65 years from the WHO/ThaiHealth Collaborative Project were surveyed between 2012 and 2014 about their experiences of being negatively affected due to another's drinking, and whether and where they sought help, focusing on four adverse aspects of harms from others' drinking...
June 13, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29889245/alcohol-screening-and-brief-intervention-in-police-custody-suites-pilot-cluster-randomised-controlled-trial-accept
#12
Michelle Addison, Ruth Mcgovern, Colin Angus, Frauke Becker, Alan Brennan, Heather Brown, Simon Coulton, Lisa Crowe, Eilish Gilvarry, Matthew Hickman, Denise Howel, Elaine Mccoll, Colin Muirhead, Dorothy Newbury-Birch, Muhammad Waqas, Eileen Kaner
Aims: There is a clear association between alcohol use and offending behaviour and significant police time is spent on alcohol-related incidents. This study aimed to test the feasibility of a trial of screening and brief intervention in police custody suites to reduce heavy drinking and re-offending behaviour. Short summary: We achieved target recruitment and high brief intervention delivery if this occurred immediately after screening. Low rates of return for counselling and retention at follow-up were challenges for a definitive trial...
June 8, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29889219/oral-binge-like-ethanol-pre-exposure-during-juvenile-adolescent-period-attenuates-ethanol-induced-conditioned-place-aversion-in-rats
#13
Keith L Williams, Melissa M Nickel, Justin T Bielak
Aims: To determine if oral ethanol self-administration produces a conditioned place preference (CPP) and to determine if ethanol pre-exposure conditions during the juvenile/adolescent period alter the conditioned effects of ethanol and subsequent ethanol self-administration. Short summary: Modified conditioned place preference paradigm allowed rats to orally self-administer ethanol followed by short duration exposure to conditioning chambers. Ethanol produced a conditioned place aversion even though rats self-administered ethanol following the final conditioning test...
June 8, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29850892/corrigendum-impact-of-alcohol-on-hiv-disease-pathogenesis-comorbidities-and-aging-integrating-preclinical-and-clinical-findings
#14
Patricia E Molina, Liz Simon, Angela M Amedee, David A Welsh, Tekeda F Ferguson
No abstract text is available yet for this article.
May 29, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29846511/dual-trajectories-of-depression-anxiety-symptoms-and-alcohol-use-and-their-implications-for-violence-outcomes-among-drug-using-urban-youth
#15
Jason E Goldstick, Kipling M Bohnert, Alan K Davis, Erin E Bonar, Patrick M Carter, Maureen A Walton, Rebecca M Cunningham
Aim: To examine dual trajectories of anxiety/depression symptoms and alcohol use among drug-using youth seeking care from an urban emergency department (ED), their baseline correlates and co-occurring trajectories of severe violence. Short summary: There were five characteristic dual trajectories of alcohol use and depression/anxiety symptoms. Community violence exposure was highest among individuals with high-depression/anxiety symptom trajectories. Individuals with concurrently high-alcohol use and depression/anxiety symptom trajectories reported that the most delinquent peer affiliations, and had the highest rates of severe violence over time...
May 26, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29846501/ethyl-glucuronide-in-alcoholic-beverages
#16
Alexander Müller, Stefanie Iwersen-Bergmann
Aims: This study examines the biomarker ethyl glucuronide (EtG) in various alcoholic beverages. Short summary: The biomarker EtG was consistently found to be a natural compound of wine, whereas it was not detected in any of the other tested alcoholic beverages, which included various distilled spirits, liqueurs and beer of different types and geographical origins. Methods: Alcoholic beverages (n = 114) were analyzed by a validated liquid chromatography/tandem mass spectrometry assay...
May 26, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29846497/soluble-klotho-and-brain-atrophy-in-alcoholism
#17
Emilio González-Reimers, Lucía Romero-Acevedo, Elisa Espelosín-Ortega, M Candelaria Martín-González, Geraldine Quintero-Platt, Pedro Abreu-González, María José de-la-Vega-Prieto, Daniel Martínez-Martínez, Francisco Santolaria-Fernández
Aim: Fibroblast growth factor (FGF-23) and α-Klotho (Klotho) levels may be altered in inflammatory conditions, possibly as compensatory mechanisms. Klotho exerts a protective effect on neurodegeneration and improves learning and cognition. No data exist about the association of Klotho and FGF-23 levels with brain atrophy observed in alcoholics. The aim of this study is to explore these relationships. Short summary: FGF-23 and Klotho levels are altered in inflammation, possibly as compensatory mechanisms...
May 26, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29846496/a-need-for-tailored-programs-and-policies-to-reduce-rates-of-alcohol-related-crimes-for-vulnerable-communities-and-young-people-an-analysis-of-routinely-collected-police-data
#18
Mieke Snijder, Bianca Calabria, Timothy Dobbins, Alice Knight, Anthony Shakeshaft
Background and aims: Given ongoing community concern about high rates of alcohol-related crimes (ARCs) experienced by disadvantaged populations, a more specific and nuanced understanding of factors associated with ARCs would help inform the development of more sophisticated programs and policies aimed at reducing ARCs. This study estimates rates of ARCs across all communities in New South Wales (NSW), Australia, using routinely collected police data; investigates whether there are differences between communities; and identifies individual and community characteristics that are significantly associated with higher rates of ARCs...
May 26, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29726886/biochemical-effects-on-the-liver-of-1-month-of-alcohol-abstinence-in-moderate-alcohol-consumers
#19
I D Munsterman, M M Groefsema, G Weijers, W M Klein, D W Swinkels, J P H Drenth, A F A Schellekens, E T T L Tjwa
In this study in healthy moderate alcohol consumers, we observe that one month of alcohol abstinence results in decreased gamma-glutamyl transferase levels, which return to baseline levels after resumption of alcohol consumption.
May 3, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29718153/corrigendum-comparing-and-combining-topiramate-and-aripiprazole-on-alcohol-related-outcomes-in-a-human-laboratory-study
#20
Carolina L Haass-Koffler, Kimberly Goodyear, William H Zywiak, Lorenzo Leggio, George A Kenna, Robert M Swift
No abstract text is available yet for this article.
April 27, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
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