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Retina

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https://www.readbyqxmd.com/read/29787465/predictive-factors-for-proliferative-vitreoretinopathy-formation-after-uncomplicated-primary-retinal-detachment-repair
#1
Kunyong Xu, Eric K Chin, Steven R Bennett, David F Williams, Edwin H Ryan, Sundeep Dev, Robert A Mittra, Polly A Quiram, John B Davies, David Wilkin Parke, Herbert Culver Boldt, David R P Almeida
PURPOSE: To determine predictive factors of proliferative vitreoretinopathy (PVR) formation after uncomplicated primary retinal detachment repair. METHODS: Retrospective, single-center, case-control study of 74 consecutive patients with (37 eyes) and without (37 eyes) PVR formation after undergoing uncomplicated primary surgery for retinal detachment repair. Logistic regression was used to assess factors associated with PVR formation. RESULTS: Retinal detachment involving the macula was 4...
May 21, 2018: Retina
https://www.readbyqxmd.com/read/29781976/posterior-scleral-contraction-to-treat-recurrent-or-persistent-macular-detachment-after-previous-vitrectomy-in-highly-myopic-eyes
#2
Linyan Zheng, Anpeng Pan, Shuangqian Zhu, Yue Wu, Liang Dong, Anquan Xue
PURPOSE: To determine the efficacy of posterior scleral contraction (PSC) to treat recurrent or persistent macular detachment after previous vitrectomy in highly myopic eyes. METHODS: We reviewed the medical records of patients with high myopia and recurrent or persistent macular detachment after previous vitrectomy treated with PSC at our hospital between April 2013 and March 2017. Fourteen eyes (14 patients; mean age, 58.93 ± 11.08 years) were included. Sclera cross-linked with genipin was used for PSC...
May 16, 2018: Retina
https://www.readbyqxmd.com/read/29781975/novel-best1-mutations-detected-by-next-generation-sequencing-in-a-chinese-population-with-vitelliform-macular-dystrophy
#3
Jingli Guo, Fengjuan Gao, Wenyi Tang, Yuhe Qi, Yi Xuan, Wei Liu, Lei Li, Xiaofeng Ye, Gezhi Xu, Jihong Wu, Yongjin Zhang
PURPOSE: To characterize novel BEST1 mutations and the phenotype-genotype correlations in vitelliform macular dystrophy in a Chinese population. METHODS: Seventeen individuals affected by vitelliform macular dystrophy underwent detailed ophthalmic examinations, including a best-corrected visual acuity test, slit-lamp biomicroscopy, fundus photography, spectral-domain optical coherence tomography, fundus autofluorescence, fluorescein angiography, and optical coherence tomography angiography...
May 16, 2018: Retina
https://www.readbyqxmd.com/read/29781974/prognostic-value-of-shape-descriptive-factors-for-the-progression-of-geographic-atrophy-secondary-to-age-related-macular-degeneration
#4
Maximilian Pfau, Moritz Lindner, Lukas Goerdt, Sarah Thiele, Jennifer Nadal, Matthias Schmid, Steffen Schmitz-Valckenberg, SriniVas R Sadda, Frank G Holz, Monika Fleckenstein
PURPOSE: To systematically compare the prognostic value of multiple shape-descriptive factors in the natural course of the disease. METHODS: A total of 296 eyes of 201 patients (female patients 130; mean age: 72.2 ± 13.08 years) with a median follow-up of 2.38 years from 2 prospective, noninterventional natural history studies (Fundus-Autofluorescence-in-Age-related-Macular-Degeneration [clinicaltrials.gov identifier NCT00393692], Directional-Spread-in-Geographic-Atrophy [NCT02051998]) were included in the analysis...
May 16, 2018: Retina
https://www.readbyqxmd.com/read/29771728/long-term-prognostic-factors-for-visual-improvement-after-epiretinal-membrane-removal
#5
Sohee Jeon, Byungju Jung, Won Ki Lee
PURPOSE: To identify prognostic factors that may predict the amount of long-term visual improvement after idiopathic epiretinal membrane removal. METHODS: A retrospective study of 114 patients who underwent epiretinal membrane removal was performed. The central foveal thickness, inner retinal layer thickness, inner retinal irregularity index, length of the cone outer segment tip line defect, and length of the ellipsoid zone defect were measured. The optical coherence tomography parameters that were associated with the amount of visual improvement were determined at 24 months postoperatively...
May 14, 2018: Retina
https://www.readbyqxmd.com/read/29757807/thicknesses-of-central-macular-retinal-nerve-fiber-and-ganglion-cell-inner-plexiform-layers-in-patients-with-hypertension
#6
Soo Hyun Lee, Woo Hyuk Lee, Hyung Bin Lim, Young Joon Jo, Jung Yeul Kim
PURPOSE: To compare retinal thickness between patients with chronic hypertension without retinopathy, hypertensive retinopathy, Keith-Wagener-Barker Grade IV status, and normal controls using spectral domain optical coherence tomography. METHODS: In this retrospective study, we analyzed patients who visited our retinal clinic from January 2013 to February 2016. Of those included, 58 eyes of 58 patients were in the healthy control group (Group A), 37 eyes of 37 patients were in the chronic hypertension without retinopathy group (disease duration of at least 10 years; Group B), and 31 eyes of 31 patients with relieved hypertensive retinopathy (Grade IV hypertensive retinopathy a year or more ago but no longer had hypertensive retinopathy at the time of the study; Group C)...
May 11, 2018: Retina
https://www.readbyqxmd.com/read/29746406/hemi-temporal-internal-limiting-membrane-peeling-is-as-effective-and-safe-as-conventional-full-peeling-for-macular-hole-surgery
#7
Akira Shiono, Jiro Kogo, Hiroki Sasaki, Ryo Yomoda, Tatsuya Jujo, Naoto Tokuda, Yasushi Kitaoka, Hitoshi Takagi
PURPOSE: To investigate the efficacy of hemi-temporal internal limiting membrane (ILM) peeling for idiopathic macular hole. METHODS: The medical records of patients with macular holes who had undergone vitrectomy with ILM peeling were studied. Forty-two eyes with macular hole were divided into 2 groups based on surgical procedure (hemi-temporal ILM peeling [hemi group]: 15 eyes; 360° ILM peeling [360° group]: 27 eyes). The closure rates and distances between the optic disc and the intersection of two retinal vessels most closely located nasally or temporally to the macular hole were compared...
May 9, 2018: Retina
https://www.readbyqxmd.com/read/29746405/long-term-physical-stability-sterility-and-anti-vegf-bioactivity-of-repackaged-bevacizumab-in-2-ml-glass-vials
#8
Jan S Peterson, Kenneth Rockwell, Ingrid U Scott, Michael S Ip, Paul C VanVeldhuisen, Barbara A Blodi
PURPOSE: Repackaged bevacizumab in single-dose, prefilled syringes for intravitreal injection is available, but with shelf life limited from 60 days to 90 days. For the Study of COmparative Treatments for REtinal Vein Occlusion 2 (SCORE2), 2-mL sterile glass vials were used rather than prefilled syringes to provide a longer shelf life for study supplies. METHODS: Repackaged bevacizumab in glass vials was tested at release and, for 1 lot, after 1, 3, 6, and 12 months for physical stability, including concentration, purity and appearance, and for sterility and endotoxins...
May 9, 2018: Retina
https://www.readbyqxmd.com/read/29746404/diagnostic-and-therapeutic-challenges
#9
Kevin I Rosenberg, Robert Swan, Robert Hampton
No abstract text is available yet for this article.
May 9, 2018: Retina
https://www.readbyqxmd.com/read/29746403/amish-eye-study-baseline-spectral-domain-optical-coherence-tomography-characteristics-of-age-related-macular-degeneration
#10
Muneeswar G Nittala, Yeunjoo E Song, Rebecca Sardell, Larry D Adams, Samuel Pan, Swetha B Velaga, Violet Horst, Debra Dana, Laura Caywood, Renee Laux, Denise Fuzzell, Sarada Fuzzell, William K Scott, Jessica N Cooke Bailey, Robert P Igo, Jonathan Haines, Margaret A Pericak-Vance, SriniVas R Sadda, Dwight Stambolian
PURPOSE: To describe spectral domain optical coherence tomography (SD-OCT) findings in an Amish cohort to assess SD-OCT markers for early age-related macular degeneration (AMD). METHODS: The authors performed a family-based prospective cohort study of 1,146 elderly Amish subjects (age range 50-99 years) (2,292 eyes) who had a family history of at least 1 individual with AMD. All subjects underwent complete ophthalmic examinations, SD-OCT using both Cirrus and Spectralis (20 × 20° scan area) instruments, fundus autofluorescence, infrared imaging, and color fundus photography...
May 9, 2018: Retina
https://www.readbyqxmd.com/read/29746416/crispr-genome-surgery-in-the-retina-in-light-of-off-targeting
#11
Galaxy Y Cho, Kellie A Schaefer, Alexander G Bassuk, Stephen H Tsang, Vinit B Mahajan
PURPOSE: Recent concerns regarding the clinical utilization of clustered regularly interspaced short palindromic repeats (CRISPR) involve uncertainties about the potential detrimental effects that many arise due to unintended genetic changes, as in off-target mutagenesis, during CRISPR genome surgery. This review gives an overview of off-targeting detection methods and CRISPR's place in the clinical setting, specifically in the field of ophthalmology. RESULTS: As CRISPR utilization in the laboratory setting has increased, knowledge regarding CRISPR mechanisms including its off-target effects has also increased...
May 7, 2018: Retina
https://www.readbyqxmd.com/read/29746415/histology-of-geographic-atrophy-secondary-to-age-related-macular-degeneration-a-multilayer-approach
#12
Miaoling Li, Carrie Huisingh, Jeffrey Messinger, Rosa Dolz-Marco, Daniela Ferrara, K Bailey Freund, Christine A Curcio
PURPOSE: To systematically characterize histologic features of multiple chorioretinal layers in eyes with geographic atrophy, or complete retinal pigment epithelium (RPE) and outer retinal atrophy, secondary to age-related macular degeneration, including Henle fiber layer and outer nuclear layer; and to compare these changes to those in the underlying RPE-Bruch membrane-choriocapillaris complex and associated extracellular deposits. METHODS: Geographic atrophy was delimited by the external limiting membrane (ELM) descent towards Bruch membrane...
May 3, 2018: Retina
https://www.readbyqxmd.com/read/29746414/five-year-outcomes-of-intravitreal-ranibizumab-for-choroidal-neovascularization-in-patients-with-pathologic-myopia
#13
Yuka Onishi, Tae Yokoi, Kaori Kasahara, Takeshi Yoshida, Natsuko Nagaoka, Kosei Shinohara, Yuichiro Kaneko, Mitsuki Suga, Kengo Uramoto, Akiko Ohno-Tanaka, Kyoko Ohno-Matsui
PURPOSE: To determine the 5-year outcome of intravitreal ranibizumab (IVR) for myopic choroidal neovascularization (CNV). METHOD: We retrospectively analyzed the medical records of 51 eyes of 51 consecutive patients with myopic CNV who had been treated with IVR with a minimum follow-up period of 5 years after the initial IVR injection. The factors that predicted the best-corrected visual acuity (BCVA) at 5 years after IVR were determined by multiple regression analysis...
May 3, 2018: Retina
https://www.readbyqxmd.com/read/29746413/intravitreal-anti-vascular-endothelial-growth-factor-treatment-at-2-month-intervals-reduces-foveal-avascular-zone-enlargement-and-vision-loss-in-radiation-maculopathy-a-pilot-study
#14
Alejandra Daruich, Alexandre Matet, Ann Schalenbourg, Leonidas Zografos
PURPOSE: To evaluate, in eyes with radiation maculopathy, the effect of 2-month-interval anti-vascular endothelial growth factor therapy on best-corrected visual acuity and foveal avascular zone (FAZ) enlargement using optical coherence tomography angiography. METHODS: Consecutive treatment-naive patients with radiation maculopathy after proton beam irradiation for choroidal melanoma were retrospectively included. Clinical and optical coherence tomography angiography data at baseline and the 6-month visit were recorded...
May 3, 2018: Retina
https://www.readbyqxmd.com/read/29746412/rapid-progression-of-foveomacular-retinoschisis-in-young-myopics
#15
Zhongcui Sun, Hua Gao, Min Wang, Qing Chang, Gezhi Xu
PURPOSE: To describe a foveomacular retinoschisis that has not been described. METHODS: Patients with foveomacular retinoschisis were included. Exclusion criteria included refractive error over -6.00 diopters, presence of posterior staphyloma, positive RS1-gene mutation, family history of retinoschisis, optic disk abnormalities, or glaucoma. Vitrectomy was performed on eyes with functional or structural deterioration. RESULTS: Seventeen eyes from 10 patients (15-30 years old, 8 females and 2 males) with foveoschisis were recruited, with bilateral involvement in 7 patients and unilateral in 3 patients...
May 2, 2018: Retina
https://www.readbyqxmd.com/read/29746411/reduced-choriocapillaris-flow-in-eyes-with-type-3-neovascularization-and-age-related-macular-degeneration
#16
Enrico Borrelli, Eric H Souied, K Bailey Freund, Giuseppe Querques, Alexandra Miere, Orly Gal-Or, Riccardo Sacconi, SriniVas R Sadda, David Sarraf
PURPOSE: To study choriocapillaris (CC) flow in eyes with Type 3 neovascularization (NV) and age-related macular degeneration, using optical coherence tomography angiography analysis. METHODS: In this multicenter, retrospective, observational study, we collected data from 21 patients with unilateral Type 3 NV and age-related macular degeneration, based on clinical examination, structural optical coherence tomography, and fluorescein angiography when available. An additional group of 20 nonneovascular age-related macular degeneration eyes with unilateral Type 1 or Type 2 NV due to age-related macular degeneration was included for comparison...
April 30, 2018: Retina
https://www.readbyqxmd.com/read/29746410/multimodal-imaging-in-a-case-of-fundus-pulverulentus
#17
Rupak Roy, Kumar Saurabh, Dhaivat Shah
No abstract text is available yet for this article.
April 30, 2018: Retina
https://www.readbyqxmd.com/read/29746409/clinical-characteristics-long-term-surgical-outcomes-and-prognostic-factors-of-epiretinal-membrane-in-young-patients
#18
Wenwen Chen, Xiao Shen, Peijun Zhang, Gezhi Xu, Rui Jiang, Xin Huang, Yanqiong Zhang, Qing Chang
PURPOSE: To explore the clinical characteristics, long-term surgical outcomes, and prognostic factors for vision improvement in young patients with epiretinal membrane (ERM). METHODS: A cohort of in-patients aged <40 years and underwent surgical removal of ERM were selected from medical records between January 2009 and December 2015. Data from pre- and postoperative examinations were analyzed for evaluation of surgical outcome. RESULTS: A total of 142 eyes of 140 patients were included...
April 30, 2018: Retina
https://www.readbyqxmd.com/read/29746408/diagnostic-and-therapeutic-challenges
#19
Manisha Agarwal, Rahul Mayor, Richa Ranjan, Gregg T Kokame
No abstract text is available yet for this article.
April 30, 2018: Retina
https://www.readbyqxmd.com/read/29746407/swept-source-optical-coherence-tomography-angiography-reveals-internal-limiting-membrane-peeling-alters-deep-retinal-vasculature
#20
Zofia Michalewska, Jerzy Nawrocki
PURPOSE: To describe morphology of retinal and choroidal vessels in swept-source optical coherence tomography angiography before and after vitrectomy with the temporal inverted internal limiting membrane (ILM) flap technique for full-thickness macular holes. METHODS: Prospective, observational study of 36 eyes of 33 patients with full-thickness macular holes swept-source optical coherence tomography angiography was performed in patients before and 1 month after vitrectomy...
April 30, 2018: Retina
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