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Youxin Chen, Tarun Sharma, Xiaorong Li, Yanping Song, Qing Chang, Renxin Lin, Anna Egger, Arthur Foo, Margarita Gekkieva, Timothy Y Y Lai
PURPOSE: To evaluate the efficacy and safety of 2 dosing regimens of ranibizumab 0.5 mg versus verteporfin photodynamic therapy in Asian patients with visual impairment due to myopic choroidal neovascularization. METHODS: Eligible patients (aged ≥18 years) were randomized 2:2:1 to Group I (n = 182; ranibizumab treatment guided by visual acuity stabilization criteria); Group II (n = 184; ranibizumab treatment guided by disease activity); or Group III (n = 91; verteporfin photodynamic therapy on Day 1; from Month 3, ranibizumab/verteporfin photodynamic therapy/both treatment guided by disease activity)...
September 20, 2018: Retina
Susan B Bressler, Isoken Odia, Adam R Glassman, Ronald P Danis, Sandeep Grover, G Robert Hampton, Lee M Jampol, Maureen G Maguire, Michele Melia
PURPOSE: To explore 5-year changes from baseline in diabetic retinopathy severity among eyes treated with ranibizumab for diabetic macular edema. METHODS: Diabetic retinopathy severity was assessed from study visits and annual fundus photographs among participants in Protocol I ( The proportion of eyes that improved at annual examinations and the cumulative probability of worsening through 5 years were estimated. RESULTS: Among 235 participants with nonproliferative diabetic retinopathy at baseline, there were 29%, 28%, and 32% of eyes with retinopathy improvement at 1, 3, and 5 years, respectively...
September 18, 2018: Retina
Gurdeep Jhaj, Tina Damarjian, Laura Kopplin
No abstract text is available yet for this article.
September 18, 2018: Retina
Aleksandra Rachitskaya, Leslie Lane, Justis Ehlers, Meghan DeBenedictis, Alex Yuan
No abstract text is available yet for this article.
September 17, 2018: Retina
Robert A Sisk, Deepam Rusia, Brian G Zamora, Alex Kuley, Brian W Toussaint
PURPOSE: To investigate the effect of serial anterior chamber (AC) paracenteses in eyes with sustained elevations of intraocular pressure (IOP) in the setting of repeated intravitreal injections (IVI) of anti-vascular endothelial growth factor medications. METHODS: This is a retrospective records review of patients undergoing IVI of anti-vascular endothelial growth factor medication (bevacizumab, ranubizumab, or aflibercept), who demonstrated a sustained elevation of preinjection IOP and also received AC paracentesis immediately after IVI on at least three consecutive visits...
September 17, 2018: Retina
Mustafa Iftikhar, Ramandeep Kaur, April Nefalar, Bushra Usmani, Saleema Kherani, Isra Rashid, Etienne Schönbach, Michelle Petri, Hendrik P N Scholl, Syed M Shah
PURPOSE: To assess the sensitivity and specificity of microperimetry as a screening test to detecting hydroxychloroquine retinopathy. METHODS: Retrospective cohort study. Patients with history of hydroxychloroquine use for more than 5 years and with concomitant microperimetry and multifocal electroretinogram testing were retrospectively reviewed. Microperimetry was considered positive if there were three or more contiguous scotoma points in the parafoveal region...
September 17, 2018: Retina
Gowtham Jonna, Ian A Thompson, Thomas A Mendel, Stephen J Kim
PURPOSE: To evaluate 5-year functional outcomes involving the inner retina after epiretinal membrane (ERM) surgery. METHODS: The study eye (SE) and fellow eye (FE) of 20 patients undergoing ERM surgery were examined preoperatively and at 3, 12, 24, 36, 48, and 60 months postoperatively. Retinal nerve fiber layer and ganglion cell-inner plexiform layer (GC-IPL) thicknesses were analyzed using spectral domain optical coherence tomography. Humphrey visual field mean deviation, pattern SD, and qualitative changes were assessed and compared over time...
September 17, 2018: Retina
Roy Schwartz, Sobha Sivaprasad, Rebecca Macphee, Patricia Ibanez, Pearse A Keane, Michel Michaelides, Sui Chien Wong
PURPOSE: To determine vascular change at the macula in both eyes in unilateral pediatric Coats disease using optical coherence tomography angiography. METHODS: Retrospective case-series. Thirteen eyes of pediatric patients with a diagnosis of unilateral Coats disease of various stages were compared with 13 fellow eyes. Optical coherence tomography angiography images were acquired using the RTVue XR Avanti. Scans were analyzed with novel projection artifact removal software and improved segmentation...
September 17, 2018: Retina
Aniruddha Agarwal, Kanika Aggarwal, Kusum Sharma, Aman Sharma, Digambar Behera, Suryaprakash Sharma, Nirbhai Singh, Amod Gupta, Vishali Gupta, Thomas Albini
No abstract text is available yet for this article.
September 17, 2018: Retina
Elisabetta Miserocchi, Andrés J M Ferreri, Chiara Giuffrè, Maria G Cangi, Ilaria Francaviglia, Teresa Calimeri, Maurilio Ponzoni, Lorenza Pecciarini, Francesco M Bandello, Giulio M Modorati
PURPOSE: To detect the presence of MYD88 L265P mutation in the aqueous humor of patients with cytologically proven vitreoretinal lymphoma. METHODS: Eight consecutive patients with bilateral vitreoretinal lymphoma (16 eyes) were prospectively evaluated. Genomic DNA was extracted from aqueous samples after paracentesis and vitreous humor samples after diagnostic vitrectomy. MYD88 codon 265 mutation was investigated by both amplification-refractory mutation system polymerase chain reaction approach and pyrosequencing assay in the aqueous humor of all patients and in the vitreous of 6 patients...
September 7, 2018: Retina
Hiroshi Fukukita, Yasuki Ito, Takeshi Iwase, Hiroki Kaneko, Shunsuke Yasuda, Keiko Kataoka, Hiroko Terasaki
PURPOSE: The internal limiting membrane (ILM), the innermost basement membrane of the retina, is peeled occasionally during vitreous surgery. This study aimed to investigate the effect of ILM loss on the retina. METHODS: We used optical coherence tomography to retrospectively evaluate retinal changes in 26 eyes (11 ILM-peeled and 15 ILM-unpeeled eyes) of 26 patients after vitrectomy for retinal detachment. In addition, we studied six eyes of three patients with Alport syndrome, in which ILM is genetically impaired...
September 7, 2018: Retina
Yong Zhang, Xiao Chen, Lin Hong, Ying Yan, Miao Zeng, Zhijian Huang, Ran Liu, Qin Ding
PURPOSE: To compare clinical outcomes in eyes with macular hole (MH) managed by either facedown (FD) or no-FD (nFD) postoperative positioning protocols. METHODS: This is a prospective randomized cohort study. Eighty eyes of 80 consecutive patients with MH who had undergone vitrectomy surgery with internal limiting membrane peeling and gas tamponade were included in this study. Forty eyes of 40 patients who were kept in FD position for 3 days after surgery were assigned to the FD group, 40 eyes of 40 patients with nFD positioning were assigned to the nFD group...
September 7, 2018: Retina
David Ancona-Lezama, Lauren A Dalvin, J Antonio Lucio-Alvarez, Pascal Jabbour, Carol L Shields
PURPOSE: To determine whether treatment order affects ophthalmic vascular event rates after intra-arterial chemotherapy (IAC) for retinoblastoma. METHODS: Patients who received IAC as primary or secondary treatment for retinoblastoma from January 2009 to January 2018 were included. All eyes were imaged with fundus photography and fluorescein angiography. Patient characteristics and vascular event rates were compared using t-test and Fisher's exact test. RESULTS: There were 196 patients treated with 682 infusions of IAC, divided into primary (no previous therapy, 98 eyes of 98 patients, 328 infusions) and secondary (after other therapy, 105 eyes of 98 patients, 354 infusions) treatment...
September 7, 2018: Retina
Frederick T Collison, Winston Lee, Gerald A Fishman, Jason C Park, Jana Zernant, J Jason McAnany, Rando Allikmets
PURPOSE: To investigate the Stargardt disease phenotype associated with an unusually common and "extremely hypomorphic" ABCA4 variant, p.N1868I. METHODS: The charts of 27 patients with p.N1868I on one allele and a severe/deleterious mutation on the other allele were reviewed. Subjective age of onset, best-corrected visual acuity, and stage of disease were recorded for all 27 patients, 18 of whom had multiple visits. When available, fundus photography, spectral domain optical coherence tomography, fundus autofluorescence, full-field electroretinograms, Goldmann visual fields, and fluorescein angiography were included...
September 7, 2018: Retina
Clara Vazquez-Alfageme, Luke Nicholson, Robin D Hamilton, Praveen J Patel
No abstract text is available yet for this article.
September 1, 2018: Retina
Yi Xuan, Yongjin Zhang, Min Wang, Jinli Guo, Lei Li, Wei Liu, Xiaofeng Ye
No abstract text is available yet for this article.
September 1, 2018: Retina
Yoichi Sakurada, Belinda C S Leong, Ravi Parikh, Serena Fragiotta, K Bailey Freund
PURPOSE: To investigate the association between choroidal caverns, choroidal vascular hyperpermeability (CVH), and pachyvessels in eyes with pachychoroid disease. METHODS: This was a retrospective review of swept-source optical coherence tomography and indocyanine green angiography imaging performed on eyes with pachychoroid disease. RESULTS: Imaging from 21 eyes with pachychoroid disease entities (8 eyes with pachychoroid pigment epitheliopathy, 11 eyes with central serous chorioretinopathy, and 3 eyes with pachychoroid neovasculopathy) from 11 patients (mean 49...
September 1, 2018: Retina
Richa Ranjan, Vikram Vinayak Koundanya, Manisha Agarwal, Shalini Singh, Rahul Mayor
No abstract text is available yet for this article.
September 1, 2018: Retina
Petra P Larsen, Akio Oishi, Mohammad Seleman Bedar, Philipp K R Heymer, Christoph R Clemens, Susanna König, Matthias Gutfleisch, Daniel Pauleikhoff, Nicole Eter, Armin Wolf, Frank G Holz, Tim U Krohne
PURPOSE: To assess efficacy of intravitreal ranibizumab in retinal pigment epithelium tears secondary to neovascular age-related macular degeneration. METHODS: The Ranibizumab In Pigment epithelial tears secondary to age-related macular degeneration (RIP) study is a prospective, single-arm, multicenter, investigator-initiated trial. Twenty four eyes of 24 patients with a retinal pigment epithelium tear secondary to age-related macular degeneration received monthly intravitreal injection of 0...
September 1, 2018: Retina
Irina De la Huerta, Yoshihiro Yonekawa, Benjamin J Thomas, Antonio Capone
No abstract text is available yet for this article.
September 1, 2018: Retina
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