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Journal of Pharmaceutical and Biomedical Analysis

Yue Cui, Ting Liu, Ye Zhang, Roujia Wang, Xiaozhou Liu, Qili Zhang, Peipei Yu, Yunli Zhao, Zhiguo Yu
Incompatible herb pair Gansui-Gancao is recorded in "eighteen incompatible" medicaments in many monographs of TCM (Traditional Chinese Medicine) which means the two herbs can not be co-used in most cases. However, Gansuibanxia decoction composed of Gansui(Kansui), Banxia(Pinellia), Shaoyao(Peony) and Gancao(Liquorice) is a traditional Chinese formula which has been clinically employed for the treatment of cancerous ascites, pleural effusion, peritoneal effusion, etc. The purpose of the study was to investigate the pharmacokinetics of main bioactive components in Gancao to explore the reasons why Gansui-Gancao can be used in Gansuibanxia decoction...
July 13, 2018: Journal of Pharmaceutical and Biomedical Analysis
Elena A Zvereva, Anatoly V Zherdev, Andey A Formanovsky, Ramadan A Abuknesha, Sergei A Eremin, Boris B Dzantiev
In this study, a fluorescence polarization immunoassay (FPIA) technique was developed to determine colchicine (COL), an alkaloid of noxious plants of the order Liliales that is used in a number of medications to treat gout. An optimal combination of the polyclonal antibody and the antigen labelled with fluorescein isothiocyanate (FITC) was selected. Conditions for the competitive interaction of the antigen in the tested samples and its fluorophore conjugate (COL-FITC) with anti-COL antibodies were optimised, and the analytical characteristics of the assay were determined...
July 11, 2018: Journal of Pharmaceutical and Biomedical Analysis
Maira N Pereira, Breno N Matos, Tais Gratieri, Marcilio Cunha-Filho, Guilherme M Gelfuso
Rifampicin (RIF) and clindamycin phosphate (CDM) are the main drugs currently used in combination to treat severe infectious diseases in hair follicles. This work describes a simple, rapid and sensitive method for simultaneous analysis of RIF and CDM in the different skin layers using high performance liquid chromatography (HPLC). The efficient chromatographic separation of CDM and RIF was succeeded using a C18 column (150 mm x 4.6 mm, 5 μm) with gradient elution using a mobile phase composed of 0...
July 10, 2018: Journal of Pharmaceutical and Biomedical Analysis
Cai Zhang, Xian Zheng, Hui Ni, Ping Li, Hui-Jun Li
Quality control (QC) is crucial for ensuring the safety and effectiveness of traditional Chinese medicines (TCMs). Due to extremely complicated phytochemical matrices and characteristic mode of "multi-component, multi-target, integrated adjustment", discovering of QC markers from TCMs is a big challenge. Fingerprint-efficacy (FE) modeling method is currently proposed as an effective and reasonable attempt. This review summarizes the methodologies of FE modeling and applications in screening QC markers, meanwhile the future perspectives are also briefly discussed so as to provide inspiration and reference for follow-up study of FE relationship for TCMs...
July 8, 2018: Journal of Pharmaceutical and Biomedical Analysis
Ya-Yun Xu, Fang Long, Ye-Qing Zhang, Jin-Di Xu, Ming Kong, Song-Lin Li
In traditional Chinese medicine practice, crude herbs are often subjected to traditional processing (Paozhi in Chinese) for a special medicinal purpose. Bran-frying is one of processing methods for Paeoniae Radix Alba (PRA). Previous studies found that paeoniflorin and paeoniflorin sulfonate, a principle bioactive compound and its sulfur-fumigation induced characteristic sulfur-containing derivative, could be used together with sulfur dioxide residue as chemical markers for the quality control of sulfur-fumigated PRA crude material...
July 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
Ivana Šagud, Debora Zanolla, Beatrice Perissutti, Nadia Passerini, Irena Škorić
Praziquantel (PZQ) is an inexpensive, low toxicity BCS II class anthelmintic drug used for the treatment of neglected tropical diseases. In earlier papers a mechanochemical activation has been used to induce physical transformations on the drug which would ameliorate its solubility and hence its bioavailability and a systematic study of the effects of varying temperature, frequency and time of milling on drug melting enthalpy and drug recovery was given. In this communication, the focus is on the degradation products that are formed during this mechanical treatment of Praziquantel...
July 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
Yan Zheng, Guifang Feng, Yufei Sun, Shu Liu, Zifeng Pi, Fengrui Song, Zhiqiang Liu
Influencing the absorption of effective components in the intestines is one of the important compatibility mechanisms of the traditional Chinese medicine. Simulation of drug absorption through an in vitro intestinal epithelial cell line is an important method to study the interaction of drug compatibility and bioavailability of drugs. In this study, the compatibility mechanism of Ding-Zhi-Xiao-Wan (DZXW) was investigated by using the in vitro Caco-2 cell monolayers model. Decomposing the formula into single herb and drug-pair to clarify the compatibility mechanism was firstly used...
July 4, 2018: Journal of Pharmaceutical and Biomedical Analysis
Monica Casale, Benedetta Pasquini, Maryam Hooshyari, Serena Orlandini, Eleonora Mustorgi, Cristina Malegori, Federica Turrini, Maria Cruz Ortiz, Luis Antonio Sarabia, Sandra Furlanetto
In this study, an alternative analytical approach for analyzing and characterizing green tea (GT) samples is proposed, based on the combination of excitation-emission matrix (EEM) fluorescence spectroscopy and multivariate chemometric techniques. The three-dimensional spectra of 63 GT samples were recorded using a Perkin-Elmer LS55 luminescence spectrometer; emission spectra were recorded between 295 and 800 nm at excitation wavelength ranging from 200 to 290 nm, with excitation and emission slits both set at 10 nm...
July 3, 2018: Journal of Pharmaceutical and Biomedical Analysis
Richard Myles Turner, Vanessa Fontana, Mark Bayliss, Sarah Whalley, Anahi Santoyo Castelazo, Munir Pirmohamed
Cardiovascular disease is a leading cause of morbidity, mortality, and healthcare expenditure worldwide. Importantly, there is interindividual variation in response to cardiovascular medications, leading to variable efficacy and adverse events. Therefore a rapid, selective, sensitive and reproducible multi-analyte HPLC-MS/MS assay for the quantification in human plasma of atorvastatin, its major metabolites 2-hydroxyatorvastatin, atorvastatin lactone and 2-hydroxyatorvastatin lactone, plus bisoprolol and clopidogrel-carboxylic acid has been developed, fully validated, and applied to a large patient study...
July 3, 2018: Journal of Pharmaceutical and Biomedical Analysis
Xu-Wen Liu, Chao-Ling Tang, Hua Zheng, Jin-Xia Wu, Fang Wu, Yi-Yi Mo, Xi Liu, Hong-Jia Zhu, Chun-Li Yin, Bang Cheng, Jun-Xiang Ruan, Fang-Ming Song, Zhao-Ni Chen, Hui Song, Hong-Wei Guo, Yong-Hong Liang, Zhi-Heng Su
Liver fibrosis is a common consequence of chronic liver diseases resulting from multiple etiologies. Furthermore, prolonged unresolved liver fibrosis may gradually progress to cirrhosis, and eventually evolve into hepatocellular carcinoma (HCC). Corydalis saxicola Bunting (CS), a type of traditional Chinese folk medicine, has been reported to have hepatoprotective effects on the liver. However, the exact mechanism of how it cures liver fibrosis requires further elucidation. In this work, an integrated approach combining proton nuclear magnetic resonance (1 H-NMR)-based metabonomics and network pharmacology was adopted to elucidate the anti-fibrosis mechanism of CS...
July 2, 2018: Journal of Pharmaceutical and Biomedical Analysis
Archana Mukherjee, Jyotsna Bhatt, Ajit Shinto, Aruna Korde, Mukesh Kumar, K Kamaleshwaran, Jephy Joseph, Haladhar Dev Sarma, Ashutosh Dash
This study explores the possibility of formulation of a cold kit for fast and easy preparation of a PET radiopharmaceutical, 68 Ga-NOTA-UBI (29-41) for clinical translation. In this study, Circular dichroism (CD) spectroscopy to study conformation of NOTA-UBI (29-41) and its comparison with conformation of UBI (29-41) was done. Pharmaceutical grade cold kits of NOTA-UBI (29-41) were formulated for radiolabeling with 68 Ga and necessary quality control tests were carried out. 68 Ga-NOTA-UBI (29-41) could be prepared in >90% radiochemical yield and radiochemical purity using cold kits of NOTA-UBI (29-41)...
July 2, 2018: Journal of Pharmaceutical and Biomedical Analysis
Peter H J Keizers, Celine Vanhee, Eef M W van den Elzen, Wim H de Jong, Bastiaan J Venhuis, Hennie M Hodemaekers, Paul Schwillens, Daan G W Lensen
Facial treatments with dermal fillers for medical or esthetic purposes occasionally give rise to adverse effects, ranging from temporary effects such as reddening of the skin, to long term effects such as hardening of tissue. There appears to be a relationship between the lifetime of the filler product and the risk for adverse effects. The lifetime of hyaluronic acid-based fillers is dependent on the presence and amount of crosslinking agents such as 1,4-butanediol diglycidyl ether (BDDE). It would therefore make sense to establish methodology to analyze the crosslinking grade of HA-based filler products on a routine basis...
July 2, 2018: Journal of Pharmaceutical and Biomedical Analysis
Enrico Tenaglia, Anna Ferretti, Laurent A Decosterd, Dominique Werner, Thomas Mercier, Nicolas Widmer, Thierry Buclin, Carlotta Guiducci
The use of DNA aptamers in biosensors for the quantification of pharmaceuticals in the clinics would help to overcome the limitations of antibody-based detection for small molecules. The interest for such systems is proven by the ever-increasing number of aptamer-based solutions for analytics proposed in the literature as proof-of-concept demonstrators. Despite such diversity, these platforms often lack a comparative assessment of their performances against the current standard of practice in the clinics when using real samples...
June 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
Jie-Tao Chen, Xiao-Min Guo, Ping Yang, Qing Mu
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. The discovery of new anticancer compounds is of great significance. GG-8-6, cyclo-(Val1 -Leu2 -Pro3 -Ile4 -Leu5 -Leu6 -Leu7 -Val8 -Leu9 ), a new synthetic cyclic peptide, might be a potential candidate for developing new anti-HCC drugs. GG-8-6 shares no structural homology to current anti-HCC drugs. Therefore, it was necessary to develop a quantitative method for the determination of GG-8-6 in vivo. Herein, a simple, specific and sensitive liquid chromatographic method with tandem mass spectrometric detection (LC-MS/MS) was developed and validated for the analysis of GG-8-6 in rat plasma...
June 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
Marion Iguiniz, Estelle Corbel, Nicolas Roques, Sabine Heinisch
On-line selective comprehensive two-dimensional chromatography combining Reversed Phase Liquid Chromatography and Supercritical Fluid Chromatography (sRPLCxSFC) was investigated for the analysis of chiral pharmaceutical compounds. Preliminary studies were carried out with the aim of overcoming instrumental constraints which are related to such 2D-coupling. The impact of both injection solvent and injection volume on the chiral SFC second separation was assessed with a view to limiting injection effects due to mobile phase compatibility issues between both dimensions...
June 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
Agnieszka Klupczynska, Szymon Plewa, Natalia Sytek, Wojciech Sawicki, Paweł Dereziński, Jan Matysiak, Zenon J Kokot
Metabolomic studies constantly require high throughput screenings, and this drives development and optimization of methods that include more analytes in a single run, shorten the analysis time and simplify sample preparation. The aim of the study was to develop a new simple and fast liquid chromatography-tandem mass spectrometry-based methodology for quantitative analysis of a panel of ten organic acids in urine. The metabolites selected for the study include ten molecules potentially associated with cancer development...
June 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
Laura Fumagalli, Luca Giovanni Regazzoni, Valentina Straniero, Ermanno Valoti, Giancarlo Aldini, Giulio Vistoli, Marina Carini, Claudia Picozzi
Nowadays, parabens have been replaced by domiphen bromide, which is widely used in pharmaceutical and cosmetic products. The main aim of this study was to investigate stressed degradation products of domiphen bromide by mean of a rapid, specific and reliable LC-ESI MS/MS since phenyl bromination may occur due to the oxidation of bromide counter ion under oxidative conditions. LC-ESI-MS/MS have characterized a new compound, p-bromodomiphen, as the only degradation product and structure elucidation was also confirmed by the synthesis of the standard...
June 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
L Malatesta, D Cosco, D Paolino, F Cilurzo, N Costa, A Di Tullio, M Fresta, C Celia, L Di Marzio, M Locatelli
In this manuscript we aimed at the simultaneous separation and quantification of Gemcitabine and Irinotecan hydrochloride (injected both as single components and in combination) from Sprague Dawley rat plasma by using a validated method obtained through the use of a High Performance Liquid Chromatography (HPLC)-diode array detector (DAD). Gemcitabine and Irinotecan hydrochloride were detected and quantified using a Zorbax Extend C-18 column (250 mm × 4.6 mm; 5 μm particle size) in gradient elution mode...
June 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
Dawei Li, Aijing Leng, Yan Qi, Ruichen Wang, Lianhong Yin, Xu Han, Chengpeng Sun, Xingjie Guo, Linlin Fang, Jinyong Peng
Schisandrin B (Sch B) has received much attention owing to its various biological activities. Schisandrin B exists as a racemate in "wuweizi", a traditional Chinese medicine in China. In the present study, a novel chiral LC-MS/MS method was developed for enantioselective separation and determination of Schisandrin B in rat plasma. The plasma samples were prepared by liquid-liquid extraction (LLE). Schisandrol B was used as internal standard. Chiral separation was obtained on a Chiralpak IC column using 0...
June 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
Qi-Le Zhou, Di-Na Zhu, Xiu-Wei Yang, Wei Xu, Ying-Ping Wang
A new and sensitive ultra fast liquid chromatography coupled with electrospray ionization triple quadrupole tandem mass spectrometry (UFLC-MS/MS) method was developed to evaluate the quality of Red ginseng (RG) and to find out its chemical markers by comparing with multi-batches of RG and white ginseng (WG). This innovative method could quantify sixty-six saponins and their six aglycones including 10 pairs of 20(S) and 20(R) epimers within 35 min simultaneously. All compounds could be determined in individual multiple-reaction monitoring channel without interference, and the optimized method was rapid, accurate, precise, reproducible and efficient...
June 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
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