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Journal of Neuro-oncology

Simone Goebel, H Maximilian Mehdorn, Christian D Wiesner
PURPOSE: Social cognitive functions are of high clinical relevance. To date, little is known about social cognition in neurooncological patients and this domain is usually not included in standardized neurocognitive test batteries. Aim of this study was thus to assess whether social cognition could pose a useful contribution to the neurocognitive assessment in patients with intracranial tumors. METHODS: We included 30 preoperative patients with a brain tumor. Patients completed a comprehensive test battery for assessment of social cognition...
September 21, 2018: Journal of Neuro-oncology
Ian J Cohen
No abstract text is available yet for this article.
September 21, 2018: Journal of Neuro-oncology
Michael J Ciesielski, Yahao Bu, Stephan A Munich, Paola Teegarden, Michael P Smolinski, James L Clements, Johnson Y N Lau, David G Hangauer, Robert A Fenstermaker
PURPOSE: A major challenge to developing new therapies for patients with malignant brain tumors is that relatively few small molecule anticancer drugs penetrate the blood-brain barrier (BBB) well enough to provide therapeutically effective concentrations in brain tissue before drug exposure in non-CNS tissues results in unacceptable toxicity. METHODS: KX2-361, a member of a novel family of compounds with Src-kinase and tubulin polymerization inhibitory activity, demonstrates good oral bioavailability and readily crosses the BBB in mice...
September 20, 2018: Journal of Neuro-oncology
Yujuan Zhou, Weidong Zhao, Liang Tian, Jing Yu, Yasheng Yuan, Jing Wang
PURPOSE: To investigate the relationship between vestibular schwannoma (VS) size and the dysfunction and compensation of the vestibular system. METHODS: One hundred fifty-two patients with unilateral VS were investigated using multiple auditory-vestibular function tests such as audiometry, sensory organization test (SOT), caloric test, cervical vestibular-evoked myogenic potential (cVEMP) test, and ocular VEMP (oVEMP) test. RESULTS: In this study, 89% of patients with unilateral VS had mild to severe hearing loss on the involved side...
September 20, 2018: Journal of Neuro-oncology
Joonho Byun, Seok Ho Hong, Min Jae Yoon, Sae Min Kwon, Young Hyun Cho, Jeong Hoon Kim, Chang Jin Kim
INTRODUCTION: Central neurocytoma (CN) is a very rare neuronal neoplasm. The clinical implications of the potential prognostic factors for these lesions, including tumor atypia, have therefore not been clarified. METHODS: Forty CN patients were enrolled and reclassified as typical or atypical in accordance with an MIB-1 labeling index (LI) of above and below 2%. RESULTS: We classified our retrospective study cohort as 21 (52.5%) typical and 19 (47...
September 17, 2018: Journal of Neuro-oncology
David van Nieuwenhuizen, Linda Douw, Martin Klein, Saskia M Peerdeman, Jan J Heimans, Jaap C Reijneveld, Cornelis J Stam, Arjan Hillebrand
INTRODUCTION: Meningioma patients often have subtle cognitive deficits that might be attributed to the tumor itself, to surgical treatment, or to the occurrence of seizures and their treatment. Magnetoencephalography (MEG) analysis of resting-state functional networks (RSNs) could help to understand the neurophysiological basis of cognitive impairment in these patients. We explored the correlation between RSN functional connectivity and topology of functional networks on the one hand, and cognition on the other hand in WHO grade I meningioma patients...
September 15, 2018: Journal of Neuro-oncology
Lingyang Hua, Hongda Zhu, Jiaojiao Deng, Mi Tian, Xuewei Jiang, Hailiang Tang, Shihai Luan, Hiroaki Wakimoto, Qing Xie, Ye Gong
PURPOSE: The aim of this study was to thoroughly analyze the clinical characteristics of a large cohort of spinal meningioma (SM) from a single neurological center and identify risk factors associated with worse progression free survival and neurological function outcome. METHODS: Clinical information was retrieved from 483 SM and 9806 cranial meningioma cases who were operated in our center between 2003 and 2013. 194 SM patients who were followed at the main branch were used for prognostic analyses that included both recurrence free survival and neurological functions based on Modified McCormick scale (MMS)...
September 12, 2018: Journal of Neuro-oncology
Cassie Kline, S John Liu, Sai Duriseti, Anuradha Banerjee, Theodore Nicolaides, Shannon Raber, Nalin Gupta, Daphne Haas-Kogan, Steve Braunstein, Sabine Mueller
BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a rare, aggressive brain tumor with no known cure. Reirradiation (reRT) at recurrence can prolong survival. The impact of irradiation may be heightened when combined with PD-1 inhibition. We describe our experience using reRT, with or without PD-1 inhibition, in a cohort of patients with recurrent DIPG. METHODS: We performed a retrospective cohort analysis of children who received reRT with or without concomitant PD-1 inhibition for recurrent DIPG at a single institution between 2005 and 2016...
September 11, 2018: Journal of Neuro-oncology
Xiaojie Ding, Zheng Wang, Di Chen, Yinyan Wang, Zheng Zhao, Chongran Sun, Dikang Chen, Chao Tang, Ji Xiong, Lingchao Chen, Zhenwei Yao, Ying Liu, Xiaoqin Wang, Daniel P Cahill, John F de Groot, Tao Jiang, Yu Yao, Liangfu Zhou
PURPOSE: Maximal surgical resection is associated with survival benefit in the majority of studies in adult diffuse glioma. This study aims to characterize the prognostic value of surgical resection in molecular subgroups of diffuse glioma. METHODS: 1178 patients with diffuse glioma from our centers and 422 from TCGA dataset were collected. The Kaplan-Meier analysis and multivariable Cox regression models were conducted to identify the prognostic value of surgical resection through different histological and molecular stratifications...
September 11, 2018: Journal of Neuro-oncology
Hwa Kyung Byun, Seong Yi, Hong In Yoon, Se Hoon Kim, Jaeho Cho, Chang-Ok Suh
PURPOSE: This study evaluated the outcomes of radiotherapy (RT) for spinal ependymoma with adverse features, such as incomplete resection or disseminated disease. METHODS: Twenty-five patients underwent RT for spinal cord ependymoma during 1991-2016. Twenty-four patients had gross disease on the pre-RT spinal magnetic resonance images. Six patients (24%) had disseminated disease. The World Health Organization grades were I (12 patients), II (12 patients), and III (1 patient)...
September 10, 2018: Journal of Neuro-oncology
Dieter Henrik Heiland, Gerrit Haaker, Ralf Watzlawick, Daniel Delev, Waseem Masalha, Pamela Franco, Marcia Machein, Ori Staszewski, Oliver Oelhke, Nils Henrik Nicolay, Oliver Schnell
There was a typo in the third author's name in the initial online publication.
September 10, 2018: Journal of Neuro-oncology
Hans-Georg Wirsching, Johannes Konstantin Richter, Felix Sahm, Corinne Morel, Niklaus Krayenbuehl, Elisabeth Jane Rushing, Andreas von Deimling, Antonios Valavanis, Michael Weller
PURPOSE: Preoperative embolization of radiographically suspected meningiomas is often performed to facilitate tumor resection. Its effects on the subsequent disease course of meningioma patients have not been studied in detail and randomized trials are lacking. The purpose of this study was to explore associations of preoperative meningioma embolization with postoperative outcome. PATIENTS AND METHODS: Patients undergoing resection of an intracranial meningioma at the University Hospital Zurich 2000-2013 (N = 741) were reviewed for the inclusion of pre-operative embolization in the management strategy...
September 8, 2018: Journal of Neuro-oncology
Zjiwar H A Sadik, Patrick E J Hanssens, Jeroen B Verheul, Guus N Beute, Suan Te Lie, Sieger Leenstra, Hilko Ardon
OBJECTIVE: In recent years, gamma knife radiosurgery (GKRS) has become increasingly more popular as a salvage treatment modality for patients diagnosed with recurrent gliomas. The goal of GKRS for recurrent glioma patients is to improve survival rates with minimal burden for these patients. The emphasis of this report is on local tumor control (TC), clinical outcome and survival analysis. METHODS: We performed a retrospective analysis of prospectively collected data of all patients who underwent GKRS for gliomas at the Gamma Knife Center Tilburg between 23-09-2002 and 21-05-2015...
September 6, 2018: Journal of Neuro-oncology
Guanmin Quan, Yongli Zheng, Jun Chen, Bei Hua, Xiaoli Ji, Kexin Zhang, Duo Gao, Jianming Lei, Tao Yuan
PROPOSE: To explore the value of unmeasurable enhancement pattern of residual cavity in predicting survival at early stage after gross-total resection in high-grade glioma (HGG) patients. METHODS: This retrospective study enrolled consecutive 51 HGG patients with unmeasurable enhancement who underwent gross-total resection followed by concurrent chemoradiotherapy and adjuvant chemotherapy. We evaluated the enhancement patterns of residual cavity on contrast-T1WI made within 1 month after tumor resection (20 ± 3 days)...
September 4, 2018: Journal of Neuro-oncology
Joshua D Palmer, Deepak Bhamidipati, Andrew Song, Harriet B Eldredge-Hindy, Joshua Siglin, Tu D Dan, Colin E Champ, Isabella Zhang, Voichita Bar-Ad, Lyndon Kim, Jon Glass, James J Evans, David W Andrews, Maria Werner-Wasik, Wenyin Shi
PURPOSE/OBJECTIVES: We report the outcomes of the largest cohort to date of patients receiving both bevacizumab (BEV) and fractionated stereotactic radiotherapy (FSRT) for progressive or recurrent high grade glioma (HGG). Furthermore, the sequence of these two treatment regimens was analyzed to determine an optimal treatment paradigm for recurrent HGG. MATERIALS/METHODS: After Institutional Review Board approval, patients with pathologically confirmed WHO grade III anaplastic astrocytoma (AA) or IV glioblastoma multiforme (GBM) glioma who subsequently underwent re-irradiation at recurrence with FSRT were retrospectively reviewed...
September 4, 2018: Journal of Neuro-oncology
Aditya V Karhade, Quirina C B S Thio, Paul T Ogink, Joseph H Schwab
BACKGROUND: Elevated serum alkaline phosphatase has been previously studied as a biomarker for progression of metastatic disease and implicated in adverse skeletal events and worsened survival. The purpose of this study was to determine if serum alkaline phosphatase was a predictor of short-term mortality of patients undergoing surgery for spinal metastatic disease. METHODS: The American College of Surgeons National Surgical Quality Improvement Program was queried for patients undergoing spinal surgery for metastatic disease...
September 1, 2018: Journal of Neuro-oncology
Ashley S Margol, Kee Kiat Yeo, Caihong Xia, Arzu Onar, Nathan J Robison, David R Freyer, Girish Dhall
BACKGROUND: For several types of cancer, biological differences and outcome disparities have been documented in adolescents/young adults (AYAs, 15-39 years old) versus children. This study compared clinicopathological features and survival between younger AYAs and children with low-grade glioma (LGG), a common brain tumor among AYAs. METHODS: This was a secondary analysis of Children's Oncology Group legacy study CCG-9891/POG-9130, which enrolled participants 0-21 years of age with newly-diagnosed LGG treated with surgery alone...
September 1, 2018: Journal of Neuro-oncology
Soheil Zorofchian, Hanadi El-Achi, Yuanqing Yan, Yoshua Esquenazi, Leomar Y Ballester
PURPOSE: Primary central nervous system lymphoma (PCNSL) is a non-Hodgkin lymphoma that affects the central nervous system (CNS). Although previous studies have reported the most common mutated genes in PCNSL, including MYD88 and CD79b, our understanding of genetic characterizations in primary CNS lymphomas is limited. The aim of this study was to perform a retrospective analysis investigating the most frequent mutation types, and their frequency, in PCNSL. METHODS: Fifteen patients with a diagnosis of PCNSL from our institution were analyzed for mutations in 406 genes and rearrangements in 31 genes by next generation sequencing (NGS)...
August 31, 2018: Journal of Neuro-oncology
Jennie W Taylor, Mili Parikh, Joanna J Phillips, C David James, Annette M Molinaro, Nicholas A Butowski, Jennifer L Clarke, Nancy Ann Oberheim-Bush, Susan M Chang, Mitchel S Berger, Michael Prados
INTRODUCTION: Alterations in the CDK4/6-RB signaling pathway are common causes of cell cycle dysregulation in many cancers, including glioblastoma. Palbociclib is an oral inhibitor of CDK4/6, which leads to phosphorylation of RB1 and cell-cycle arrest. We conducted a two-arm study evaluating efficacy and tissue pharmacokinetics/pharmacodynamics of palbociclib in patients with recurrent glioblastoma. METHODS: Eligibility criteria included confirmation of RB1 proficiency by IHC; ≤ 3 relapses; KPS ≥ 60; no limit on prior treatments...
August 27, 2018: Journal of Neuro-oncology
Austin Ditmer, Bin Zhang, Taimur Shujaat, Andrew Pavlina, Nicholas Luibrand, Mary Gaskill-Shipley, Achala Vagal
PURPOSE: Texture analysis (TA) can quantify variations in surface intensity or patterns, including some that are imperceptible to the human visual system. The purpose of this study was to determine the diagnostic accuracy of radiomic based filtration-histogram TA to differentiate high-grade from low-grade gliomas by assessing tumor heterogeneity. METHODS: Patients with a histopathological diagnosis of glioma and preoperative 3T MRI imaging were included in this retrospective study...
August 25, 2018: Journal of Neuro-oncology
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