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Journal of Neuro-oncology

Julia Furtner, Anna S Berghoff, Veronika Schöpf, Robert Reumann, Benjamin Pascher, Ramona Woitek, Ulrika Asenbaum, Sebastian Pelster, Johannes Leitner, Georg Widhalm, Brigitte Gatterbauer, Karin Dieckmann, Christoph Höller, Daniela Prayer, Matthias Preusser
OBJECTIVES: The purpose of this study was to evaluate the prognostic relevance of temporal muscle thickness (TMT) in melanoma patients with newly diagnosed brain metastases. METHODS: TMT was retrospectively assessed in 146 melanoma patients with newly diagnosed brain metastases on cranial magnetic resonance images. Chart review was used to retrieve clinical parameters, including disease-specific graded prognostic assessment (DS-GPA) and survival times. RESULTS: Patients with a TMT > median showed a statistically significant increase in survival time (13 months) compared to patients with a TMT < median (5 months; p < 0...
July 14, 2018: Journal of Neuro-oncology
Bernardo Cacho-Díaz, Héctor Spínola-Maroño, Alberto González-Aguilar, Oscar Arrieta
BACKGROUND: Cancer is a leading cause of death worldwide; central nervous system metastases (CNSm) are amongst the most common complications of cancer and are associated with high morbidity and mortality. The aim of the study was to associate clinic and oncologic characteristics with the possibility of survival for ≥ 1 year. MATERIALS AND METHODS: A prospective cohort in two referral centers recollected clinical and oncologic data from patients diagnosed with CNSm...
July 12, 2018: Journal of Neuro-oncology
Andres Morales La Madrid, Surabhi Ranjan, Katherine E Warren
Gliomatosis cerebri (GC) is an aggressive glioma characterized by an invasive growth pattern and a dismal prognosis. The low incidence and non-specific symptoms at presentation pose unique challenges for early diagnosis and disease-specific research. There is no standard of care for the treatment of patients with a GC phenotype. Understanding the biology of this entity is a critical step in determining effective treatments. Toward this end, the Second International GC Group convened at National Institutes of Health, Bethesda on June 22nd-23rd 2017...
July 11, 2018: Journal of Neuro-oncology
Zhiyuan Qian, Yuping Li, Jiawei Ma, Yanping Xue, Yujun Xi, Lei Hong, Xiaoxiao Dai, Yongsheng Zhang, Xiaoyan Ji, Yanming Chen, Minfeng Sheng, Yujing Sheng, Lin Yang, Jiachi Liu, Xingliang Dai, Jia Shi, Tao Xie, Jun Dong
Nucleolar and spindle-associated protein (NUSAP1) is a microtubule and chromatin-binding protein that stabilizes microtubules to prevent depolymerization, maintains spindle integrity. NUSAP1 could cross-link spindles into aster-like structures, networks and fibers. It has also been found to play roles in progression of several cancers. However, the potential correlation between NUSAP1 and clinical outcome in patients with glioblastoma multiforme (GBM) remains largely unknown. In the current study, we demonstrated that NUSAP1 was significantly up-regulated in GBM tissues compared with adult non-tumor brain tissues both in a validated cohort and a TCGA cohort...
July 11, 2018: Journal of Neuro-oncology
Randy S D'Amico, George Zanazzi, Peter Wu, Peter Canoll, Jeffrey N Bruce
INTRODUCTION: Pineal region glioblastomas (GBM) are very rare, with approximately 46 cases described in the literature. The epidemiology, pathogenesis, and treatment of these lesions are poorly characterized. METHODS: We identified all cases of pineal region GBM treated surgically at our institution between 1990 and 2017. Demographic and clinical follow-up data were extracted from the medical records for all cases. Pathology was reviewed and classified according to 2016 World Health Organization (WHO) criteria...
July 10, 2018: Journal of Neuro-oncology
Christian F Freyschlag, Sandro M Krieg, Johannes Kerschbaumer, Daniel Pinggera, Marie-Therese Forster, Dominik Cordier, Marco Rossi, Gabriele Miceli, Alexandre Roux, Andrés Reyes, Silvio Sarubbo, Anja Smits, Joanna Sierpowska, Pierre A Robe, Geert-Jan Rutten, Thomas Santarius, Tomasz Matys, Marc Zanello, Fabien Almairac, Lydiane Mondot, Asgeir S Jakola, Maria Zetterling, Adrià Rofes, Gord von Campe, Remy Guillevin, Daniele Bagatto, Vincent Lubrano, Marion Rapp, John Goodden, Philip C De Witt Hamer, Johan Pallud, Lorenzo Bello, Claudius Thomé, Hugues Duffau, Emmanuel Mandonnet
OBJECTIVE: Imaging studies in diffuse low-grade gliomas (DLGG) vary across centers. In order to establish a minimal core of imaging necessary for further investigations and clinical trials in the field of DLGG, we aimed to establish the status quo within specialized European centers. METHODS: An online survey composed of 46 items was sent out to members of the European Low-Grade Glioma Network, the European Association of Neurosurgical Societies, the German Society of Neurosurgery and the Austrian Society of Neurosurgery...
July 10, 2018: Journal of Neuro-oncology
Yun-Sik Dho, Yong Hwy Kim, Jin Wook Kim, Chul-Kee Park, Hyun-Tai Chung, Seung-Ki Kim, Sun Ha Paek, Kyu-Chang Wang, Dong Gyu Kim
OBJECT: To analyze the outcomes of gamma knife radiosurgery (GKS) for craniopharyngiomas and elucidate the optimal strategy. METHODS: Between 1998 and 2016, 35 patients underwent GKS for the treatment of 40 recurrent or residual craniopharyngiomas. Among 40 GKSs, 22 procedures were single-session GKSs and 18 procedures were fractionated GKSs. In cases of single-session GKS, the median marginal dose was 15 Gy (range 10-20 Gy). In cases of fractionated GKS, the median marginal dose was 6 Gy (range 5-7...
July 9, 2018: Journal of Neuro-oncology
Shearwood McClelland, Oluwadamilola Sosanya, Timur Mitin, Catherine Degnin, Yiyi Chen, Albert Attia, John H Suh, Jerry J Jaboin
BACKGROUND: Tumor treating fields (TTF) harness magnetic fields to induce apoptosis in targeted regions. A 2015 landmark randomized phase III trial of newly diagnosed glioblastoma (GBM) patients demonstrated TTF + temozolomide to be superior to temozolomide alone. Given these results, we sought to assess practice patterns of providers in TTF utilization for GBM. METHODS: A survey was administered to practices in the United States self-identifying as specializing in radiation oncology, medical oncology, neuro-oncology, neurosurgery, and/or neurology...
July 9, 2018: Journal of Neuro-oncology
Simone Goebel, Hubertus Maximilian Mehdorn
PURPOSE: To date, little is known about neuropsychiatric symptoms in patients with tumors within the cerebellopontine angle (CPA). These, however, might be of clinical relevance. Aim of this study was thus to assess possible impairment in cognition, elevation in mood symptoms, and fatigue in this specific patient group. METHODS: Forty-five patients with an untreated CPA tumor (27 vestibularis schwannoma, 18 meningioma) were tested within a cross-sectional observational study in a single institution prior to neurosurgical treatment...
July 7, 2018: Journal of Neuro-oncology
Aylin Mehren, Jale Özyurt, Paula Zu Klampen, Svenja Boekhoff, Christiane M Thiel, Hermann L Müller
INTRODUCTION: The current study aimed to assess whether childhood-onset craniopharyngioma patients suffer from symptoms of apathy, as assessed by patients themselves and their close others. We further analyzed whether apathy scores are related to symptoms of depression. METHODS: Childhood-onset craniopharyngioma patients (n = 35, 16 female, median age = 22) and matched healthy controls (n = 35, 19 female, median age = 21) were asked to complete self-ratings of the Apathy Evaluation Scale, whereas informant-ratings were obtained from their close others...
July 3, 2018: Journal of Neuro-oncology
Qi Jia, Chao Liu, Jian Yang, Yong Ji, Haifeng Wei, Tielong Liu, Xinghai Yang, Cheng Yang, Jianru Xiao
PURPOSE: Chondroblastoma (CB) in the spine is extremely rare and there is little published information regarding this subject. We attempt to explore the clinical features of spinal CB and address the importance of total resection, especially total en bloc spondylectomy (TES) for the treatment of spinal CB. METHODS: Clinical data of 13 consecutive CB patients who received surgical treatment in our center between January 2006 and December 2016 were reviewed retrospectively...
July 2, 2018: Journal of Neuro-oncology
Keishi Makino, Hideo Nakamura, Naoki Shinojima, Jun-Ichiro Kuroda, Shigetoshi Yano, Yoshiki Mikami, Akitake Mukasa
PURPOSE: Primary central nervous system diffuse large B-cell lymphoma (CNS-DLBCL) is a distinct clinicopathological entity with a poor prognosis. Concurrent MYC and BCL2 overexpression predicts inferior prognosis in systemic DLBCL, although their prognostic significance remains unclear in primary CNS-DLBCL. METHODS: Pretreatment diagnostic biopsy samples were retrospectively evaluated for 79 patients with primary CNS-DLBCL who were treated between January 2001 and December 2017...
July 2, 2018: Journal of Neuro-oncology
Abdurrahman I Islim, Arousa Ali, Ananyo Bagchi, Mohammad U Ahmad, Samantha J Mills, Emmanuel Chavredakis, Andrew R Brodbelt, Michael D Jenkinson
BACKGROUND: Epilepsy is a major cause of morbidity and mortality in meningioma patients. The aims of this study were to determine which factors predispose meningioma patients to developing perioperative seizures and to understand the impact of antiepileptic drugs. METHODS: Patients treated for a histologically-confirmed intracranial meningioma at the authors' institution between 2010 and 2015 were retrospectively examined. Clinical and imaging data were assessed...
June 29, 2018: Journal of Neuro-oncology
M D Maldonado, P Batchala, D Ornan, C Fadul, D Schiff, J N Itri, R Jain, S H Patel
PURPOSE: The neuroimaging diagnosis of diffuse gliomas can be challenging owing to their variable clinical and radiologic presentation. The purpose of this study was to identify factors that are associated with imaging errors in the diagnosis of diffuse gliomas. METHODS: A retrospective case-control analysis was undertaken. 18 misdiagnosed diffuse gliomas on initial neuroimaging (cases) and 108 accurately diagnosed diffuse gliomas on initial neuroimaging (controls) were collected...
June 29, 2018: Journal of Neuro-oncology
Eric T Wong, Kenneth D Swanson
No abstract text is available yet for this article.
June 28, 2018: Journal of Neuro-oncology
Supriya Mallick, Haresh Kunhiparambath, Subhash Gupta, Rony Benson, Seema Sharma, M A Laviraj, Ashish Datt Upadhyay, Pramod Kumar Julka, Dayanand Sharma, Goura Kishor Rath
INTRODUCTION: Maximal safe surgical resection followed by adjuvant chemoradiation has been standard for newly diagnosed glioblastoma multiforme (GBM). Hypofractionated accelerated radiotherapy (HART) has the potential to improve outcome as it reduces the overall treatment time and increases the biological effective dose. METHODS: Between October 2011 and July 2017, a total of 89 newly diagnosed GBM patients were randomized to conventional fractionated radiotherapy (CRT) or HART...
June 23, 2018: Journal of Neuro-oncology
Anupam Kumar, Subhashree Nayak, Pankaj Pathak, Suvendu Purkait, Prit Benny Malgulawar, Mehar Chand Sharma, Vaishali Suri, Arijit Mukhopadhyay, Ashish Suri, Chitra Sarkar
INTRODUCTION: Although role of individual microRNAs (miRNAs) in the pathogenesis of gliomas has been well studied, their role as a clustered remains unexplored in gliomas. METHODS: In this study, we performed the expression analysis of miR-379/miR-656 miRNA-cluster (C14MC) in oligodendrogliomas (ODGs) and also investigated the mechanism underlying modulation of this cluster. RESULTS: We identified significant downregulation of majority of the miRNAs from this cluster in ODGs...
June 21, 2018: Journal of Neuro-oncology
Jiwook Ryu, Sung Ho Lee, Seok Keun Choi, Young Jin Lim
PURPOSE: This study evaluated the long-term tumor control rate (TCR) and symptomatic outcomes of patients treated with gamma knife radiosurgery (GKRS) for trigeminal schwannomas (TSs). METHODS: Thirty-two patients with TS who underwent GKRS between January 1994 and January 2013 with at least 2 years of follow-up were enrolled in the study. Clinical charts and surgical records were retrospectively reviewed to evaluate factors affecting TCR and symptomatic outcomes...
June 21, 2018: Journal of Neuro-oncology
Kristine Bauer-Nilsen, Daniel M Trifiletti, Ajay Chatrath, Henry Ruiz-Garcia, Eduardo Marchan, Jennifer Peterson, Byron C May, Jason P Sheehan
INTRODUCTION: Stereotactic radiosurgery (SRS) is a common treatment modality among patients with brain metastases, particularly from malignant melanoma. Our objective was to investigate the difference in local control, toxicity, and survival among patients with hemorrhagic and solid melanoma brain metastases. METHODS: We collected demographic, treatment, local control, toxicity, and survival for 134 patients with a total of 936 intracranial melanoma metastases who underwent SRS between 1998 and 2015...
June 20, 2018: Journal of Neuro-oncology
Vianney Gilard, Alice Goia, François-Xavier Ferracci, Florent Marguet, Nicolas Magne, Olivier Langlois, Alexis Perez, Stéphane Derrey
PURPOSE: Spinal meningiomas are slow-growing intradural-extramedullary tumors. They are usually associated with good outcomes. However, there are few descriptions of factors predictive of impaired evolution. Our objective was to identify predictive factors of post-operative deterioration as well as outcomes at follow-up. METHODS: Between 2009 and 2016, 87 patients had surgery for spinal meningioma in our referral center. Clinical presentation, management and outcomes were reported during the post-operative period and at 3-month follow-up...
June 20, 2018: Journal of Neuro-oncology
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