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Journal of Neuro-oncology

Ann Olsson, Liacine Bouaoun, Anssi Auvinen, Maria Feychting, Christoffer Johansen, Tiit Mathiesen, Beatrice Melin, Anna Lahkola, Suvi Larjavaara, Anne-Sophie Villegier, Graham Byrnes, Isabelle Deltour, Joachim Schüz
PURPOSE: Gliomas are the most common cancer of the brain, with a poor prognosis in particular for glioblastoma. In 2014, a study suggested reduced survival in relation to latency of mobile phone use among glioblastoma patients. A joint epidemiological/experimental project to study effects of RF-EMF on tumor development and progression was established. The current analysis relates to the epidemiological part and addresses whether pre-diagnostic mobile phone use was associated with survival among glioma patients...
November 12, 2018: Journal of Neuro-oncology
Nihal S Ouadah, Anthony Lecomte, Franck Robidel, Ann Olsson, Isabelle Deltour, Joachim Schüz, Kelly Blazy, Anne-Sophie Villégier
PURPOSE: Glioblastoma is a malignant brain tumor which has one of the poorest prognosis. It is not clear if toxic environmental factors can influence its aggressiveness. Recently, it was suggested that brain cancer patients with heavy cell phone use showed reduced survival. Here we aimed to assess the effect of controlled brain averaged specific absorption rate (BASAR) from heavy use of cell phone radiofrequency electromagnetic fields (RF-EMF) on in vivo C6 brain tumors in Wistar rats...
November 12, 2018: Journal of Neuro-oncology
Rimas V Lukas, Csaba Juhász, Derek A Wainwright, Charles David James, Eugene Kennedy, Roger Stupp, Maciej S Lesniak
INTRODUCTION: Glioblastoma (GBM) is the most frequent and aggressive primary tumor of the central nervous system, accounting for over 50% of all primary malignant gliomas arising in the adult brain. Even after surgical resection, adjuvant radiotherapy (RT) and temozolomide (TMZ) chemotherapy, as well as tumor-treating fields, the median survival is only 15-20 months. We have identified a pathogenic mechanism that contributes to the tumor-induced immunosuppression in the form of increased indoleamine 2,3 dioxygenase 1 (IDO1) expression; an enzyme that metabolizes the essential amino acid, tryptophan (Trp), into kynurenine (Kyn)...
November 10, 2018: Journal of Neuro-oncology
Ichiyo Shibahara, Ryuta Saito, Yoshinari Osada, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Shunji Mugikura, Mika Watanabe, Teiji Tominaga
PURPOSE: Intracranial glioblastomas with simultaneous spinal lesions prior to chemoradiation therapy or craniotomy, defined as initial spinal metastasis, are not well understood. Herein, we investigated intracranial glioblastoma and demonstrated the importance of spinal screening using gadolinium enhanced spinal magnetic resonance imaging (Gd-MRI). METHODS: Consecutive adult patients with intracranial glioblastoma were treated between 2010 and 2014 and received spinal screening using Gd-MRI...
November 9, 2018: Journal of Neuro-oncology
Kaijun Di, Naomi Lomeli, Daniela A Bota, Bhaskar C Das
PURPOSE: Magmas (mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction) is a nuclear gene that encodes the mitochondrial import inner membrane translocase subunit Tim16. Magmas is highly conserved, ubiquitously expressed in mammalian cells, and is essential for cell viability. Magmas expression levels are increased in prostate cancers and pituitary adenomas. Moreover, silencing Magmas by RNAi sensitizes pituitary adenoma cells to pro-apoptotic stimuli and induces a G0/G1 accumulation...
November 9, 2018: Journal of Neuro-oncology
Christine G Skibinski, Tara Williamson, Gregory J Riggins
PURPOSE: Meningiomas are a frequent tumor of the central nervous system. Although mostly benign, approximately 5% present as atypical or malignant tumors. Treatments for atypical meningiomas include gross total resection and radiotherapy, but about 33% of patients have recurrent tumors, sometimes as a higher grade. Recently, the brain penetrant anthelmintic drug, mebendazole, has shown promise as an anticancer agent in rodent models of glioblastoma and medulloblastoma. METHODS: The half maximal inhibitory concentration (IC50 ) effect on colony formation, cell proliferation, and caspase-3/7 markers of apoptosis of mebendazole with and without radiation was measured in vitro...
November 9, 2018: Journal of Neuro-oncology
Chinmay Satish Rahane, Arne Kutzner, Klaus Heese
INTRODUCTION: Glioblastoma multiform (GBM) is a neural stem cell (NSC)-derived malignant brain tumor with complex genetic alterations challenging clinical treatments. FAM72 is a NSC-specific protein comprised of four paralogous genes (FAM72 A-D) in the human genome, but its functional tumorigenic significance is unclear. METHODS: We conducted an in-depth expression and somatic mutation data analysis of FAM72 (A-D) in GBM using the comprehensive human clinical cancer study database cBioPortal [including The Cancer Genome Atlas (TCGA)]...
November 9, 2018: Journal of Neuro-oncology
Matthias Holdhoff, Xiaobu Ye, Anna F Piotrowski, Roy E Strowd, Shannon Seopaul, Yao Lu, Norman J Barker, Ananyaa Sivakumar, Fausto J Rodriguez, Stuart A Grossman, Peter C Burger
PURPOSE: Clinical factors and neuro-imaging in patients with glioblastoma who appear to progress following standard chemoradiation are unable to reliably distinguish tumor progression from pseudo-progression. As a result, surgery is commonly recommended to establish a final diagnosis. However, studies evaluating the pathologists' agreement on pathologic diagnoses in this setting have not been previously evaluated. METHODS: A hypothetical clinical history coupled with images of histological sections from 13 patients with glioblastoma who underwent diagnostic surgery for suspected early recurrence were sent to 101 pathologists from 50 NCI-designated Cancer Centers...
November 9, 2018: Journal of Neuro-oncology
Jing Zhao, Yu-Liang Wang, Xin-Bei Li, Man-Shi Hu, Zhu-Hao Li, Yu-Kun Song, Jing-Yan Wang, Yi-Su Tian, Da-Wei Liu, Xu Yan, Li Jiang, Zhi-Yun Yang, Jian-Ping Chu
INTRODUCTION: Few studies have applied diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) for the comprehensive assessment of gliomas [tumour grade, isocitrate dehydrogenase-1 (IDH-1) mutation status and tumour proliferation rate (Ki-67)]. This study describes the efficacy of DKI and DTI to comprehensively evaluate gliomas, compares their results. METHODS: Fifty-two patients (18 females; median age, 47.5 years) with pathologically proved gliomas were prospectively included...
November 9, 2018: Journal of Neuro-oncology
Mengqiu Cao, Weina Ding, Xu Han, Shiteng Suo, Yawen Sun, Yao Wang, Jianxun Qu, Xiaohua Zhang, Yan Zhou
INTRODUCTION: The longitudinal relaxation time in the rotating frame (T1ρ) has proved to be sensitive to metabolism and useful in application to neurodegenerative diseases. However, few literature exists on its utility in gliomas. Thus, this study was conducted to explore the performance of T1ρ mapping in tumor grading and characterization of isocitrate dehydrogenase 1 (IDH1) gene mutation status of gliomas. METHODS: Fifty-seven patients with gliomas underwent brain MRI and quantitative measurements of T1ρ and apparent diffusion coefficient (ADC) were recorded...
November 9, 2018: Journal of Neuro-oncology
Erin Wright, Ernest K Amankwah, S Parrish Winesett, Gerald F Tuite, George Jallo, Carolyn Carey, Luis F Rodriguez, Stacie Stapleton
PURPOSE: With the increasing use of imaging, there has been an increase in the number of incidentally found brain lesions in pediatric patients resulting in a treatment dilemma for physicians and emotional strain for patients and families. Adult studies support initial surveillance of incidentally found low grade appearing lesions as the most appropriate approach. The aim of this study was to evaluate incidental lesions in the pediatric population and propose an initial treatment algorithm for such lesions...
November 9, 2018: Journal of Neuro-oncology
Christina K Cramer, Neil McKee, L Doug Case, Michael D Chan, Tiffany L Cummings, Glenn J Lesser, Edward G Shaw, Stephen R Rapp
INTRODUCTION: There is no accepted classification of cognitive impairment in cancer survivors. We assess the extent of mild cognitive impairment (MCI) syndrome in brain tumor survivors using criteria adapted from the National Institute on Aging and the Alzheimer's Association (NIA-AA). METHODS: We retrospectively reviewed the cognitive data of brain tumor survivors post-radiation therapy (RT) enrolled from 2008 to 2011 in a randomized trial of donepezil versus placebo for cognitive impairment...
November 7, 2018: Journal of Neuro-oncology
Ha Son Nguyen, Ninh B Doan, Michael Gelsomino, Saman Shabani, Ahmed J Awad, Mayank Kaushal, Martin M Mortazavi
INTRODUCTION: The impact of multiple primary tumors, in the setting of malignant glioma (MG), has not been heavily explored. METHODS: We extracted demographics and clinical data from the SEER-18 registry for adult patients with MGs. The cases were separated based on the sequence of MG diagnosis relative to the other primary tumors: Group (A) One primary only or first primary of multiple primaries and Group (B) second primary or subsequent primary tumor. Incidences, frequencies, and glioma-related survivals were analyzed...
November 5, 2018: Journal of Neuro-oncology
Diana S Osorio, Neha Patel, Lingyun Ji, Richard Sposto, Joseph Stanek, Sharon L Gardner, Jeffrey C Allen, Albert Cornelius, Geoffrey B McCowage, Amanda Termuhlen, Ira J Dunkel, Melanie Comito, James Garvin, Jonathan L Finlay
BACKGROUND: The dismal outcome in children with high-grade brainstem gliomas (BSG) accentuates the need for effective therapeutic strategies. We investigated the role of intensive, including marrow-ablative, chemotherapy regimens in the treatment of young children with newly-diagnosed high-grade BSG. METHODS: Between 1991-and-2002, 15 eligible children less than 10 years of age with a diagnosis of high-grade BSG were treated on "Head-Start" I and II protocols (HSI and HSII)...
November 3, 2018: Journal of Neuro-oncology
Moran Artzi, Gilad Liberman, Deborah T Blumenthal, Felix Bokstein, Orna Aizenstein, Dafna Ben Bashat
PURPOSE: To study the repeatability of plasma volume (vp ) extracted from dynamic-contrast-enhanced (DCE) MRI in order to define threshold values for significant longitudinal changes, and to assess changes in patients with high-grade-glioma (HGG). METHODS: Twenty eight healthy subjects, of which eleven scanned twice, were used to assess the repeatability of vp within the normal-appearing brain tissue and to define threshold values for significant changes based on least-detected-differences (LDD) of mean vp values and histogram comparisons using earth-mover's-distance (EMD)...
November 3, 2018: Journal of Neuro-oncology
Jacob S Witt, Hima B Musunuru, R Adam Bayliss, Steven P Howard
PURPOSE: Meningiomas comprise up to 30% of primary brain tumors. The majority of meningioma patients enjoy high rates of control after conventional therapies. However, patients with recurrent disease previously treated with radiotherapy have few options for salvage treatment, and systemic interventions have proven largely ineffective. The aim of this study was to determine whether pulsed reduced dose rate radiotherapy (PRDR) was well tolerated in a small cohort of patients with recurrent meningioma...
November 3, 2018: Journal of Neuro-oncology
Meiqin Cai, Zhuopeng Ye, Cong Ling, Baoyu Zhang, Bo Hou
BACKGROUND: The trans-eyebrow supraorbital keyhole approach, a minimal transcranial approach, has been widely used in different types of surgery for sellar and parasellar lesions. In this study, we investigated the outcome of this approach in the surgical treatment of suprasellar and third ventricular craniopharyngioma. METHODS: Twenty-seven patients with suprasellar and third ventricular craniopharyngioma underwent surgery via a supraorbital approach between June 2007 and June 2018...
November 3, 2018: Journal of Neuro-oncology
Yohei Miyake, Jun-Ichi Adachi, Tomonari Suzuki, Kazuhiko Mishima, Ryuichiro Araki, Reina Mizuno, Ryo Nishikawa
PURPOSE: Alterations in the promoter of the telomerase reverse transcriptase (TERT) gene are a major mechanism of upregulating telomerase, which plays a crucial role in tumor development. Mutations in the TERT promoter have been observed in a subset of brain tumors, including adult gliomas and high-grade meningiomas. In pituitary adenomas (PAs), however, abnormalities in TERT are not fully understood. The present study aimed to investigate not only mutational but also methylation changes in the TERT promoter in PAs and to analyze their correlations with clinical variables...
November 3, 2018: Journal of Neuro-oncology
Ann-Christin Nickel, Xue-Yan Wan, Dino-Vitali Saban, Yin-Lun Weng, Shu Zhang, Kathy Keyvani, Ulrich Sure, Yuan Zhu
PURPOSE: Glioblastoma (GBM) is one of the most aggressive and incurable primary brain tumors. Identification of novel therapeutic targets is an urgent priority. Programmed cell death 10 (PDCD10), a ubiquitously expressed apoptotic protein, has shown a dual function in different types of cancers and in chemo-resistance. Recently, we reported that PDCD10 was downregulated in human GBM. The aim of this study was to explore the function of PDCD10 in GBM cells. METHODS: PDCD10 was knocked down in three GBM cell lines (U87, T98g and LN229) by lentiviral-mediated shRNA transduction...
November 3, 2018: Journal of Neuro-oncology
Victor M Lu, Anshit Goyal, Richard A Rovin, Adrian Lee, Kerrie L McDonald
BACKGROUND: Immune checkpoint inhibition (ICI) is an emerging immunotherapy for metastatic brain disease (MBD). Current management options include stereotactic radiosurgery (SRS), which has been shown to confer prognostic benefit in combination with ICI. However, the effect, if any, of ICI timing on this benefit is currently unclear. The aim of this study was to evaluate the effect of concurrent ICI with SRS on survival outcomes in MBD compared to non-concurrent ICI administered before or after SRS...
November 3, 2018: Journal of Neuro-oncology
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