journal
MENU ▼
Read by QxMD icon Read
search

Journal of Neuro-oncology

journal
https://www.readbyqxmd.com/read/29147860/18f-fdg-pet-ct-in-primary-brain-lymphoma
#1
Domenico Albano, Giovanni Bosio, Mattia Bertoli, Raffaele Giubbini, Francesco Bertagna
The actual role of 18F-FDG PET/CT in evaluating primary brain lymphoma is still an open issue. Brain lymphoma usually show elevated 18F-FDG uptake, often higher than other brain tumors or inflammatory processes, but the metabolic behavior of this lymphoma is not still understood. Our aim was to investigate the particular metabolic behavior of this lymphoma. Forty six patients (21 female, 25 male) with histologically-confirmed brain lymphoma who underwent 18F-FDG PET/CT from vertex to the mid-thigh for initial staging were retrospectively evaluated...
November 17, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29147859/initial-psycho-oncological-counselling-in-neuro-oncology-analysis-of-topics-and-needs-of-brain-tumour-patients
#2
Stephanie Schipmann, Eric Suero Molina, Anna Frasch, Walter Stummer, Dorothee Wiewrodt
Diagnosis of a brain tumour is associated with a tremendous disruption of emotional, physical and social well-being. Due to the complexity of the disease and the affection of the central organ, the brain, brain tumour patients differ from other cancer patients. The purpose of this study was to evaluate the concerns and burdens presented by brain tumour patients during their initial psycho-oncological consultation. We performed a retrospective analysis of 53 patients with the diagnosis of either benign or malignant brain tumour, seeking counsel by a neurosurgeon specialised in psycho-oncology...
November 17, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29147864/impact-of-who-2016-update-of-brain-tumor-classification-molecular-markers-and-clinical-outcomes-in-pleomorphic-xanthoastrocytoma
#3
Raees Tonse, Tejpal Gupta, Sridhar Epari, Jayant Goda Shastri, Mamta Gurav, Nazia Bano, Rakesh Jalali
We present outcomes of pleomorphic xanthoastrocytoma (PXA) and correlate the impact of clinical, pathologic and molecular markers. Between 2006 and 2016, 37 patients with histologically verified PXA form the study cohort. All underwent maximal safe resection; those who had good resection and young age were observed. Adjuvant radiotherapy was given in patients with some atypical features such as high MIB-1 index (> 5%), residual disease or at recurrence. Patients with anaplastic PXA were administered adjuvant radiotherapy and systemic therapy...
November 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29147863/prognostic-relevance-of-programmed-cell-death-ligand-1-expression-in-glioblastoma
#4
Kyu Sang Lee, Kyoungyul Lee, Sumi Yun, Seyoung Moon, Yujun Park, Jung Ho Han, Chae-Yong Kim, Hye Seung Lee, Gheeyoung Choe
The aim of this study was to determine the clinicopathological significance of programmed cell death ligand 1 (PD-L1) expression in glioblastoma (GBM). In a retrospective cohort of 115 consecutive patients with GBM, PD-L1 expression was determined using immunohistochemistry (IHC). Membranous and fibrillary PD-L1 staining of any intensity in > 5% neoplastic cells and tumour infiltrating immune cells (TIIs) was considered positive staining. In addition, isocitrate dehydrogenase-1 (IDH-1) (R132H) expression and cluster of differentiation 3 (CD3)-positive T-cell infiltration were investigated using IHC...
November 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29143923/impact-of-concurrent-versus-adjuvant-chemotherapy-on-the-severity-and-duration-of-lymphopenia-in-glioma-patients-treated-with-radiation-therapy
#5
Alexander J Lin, Jian L Campian, Caressa Hui, Soumon Rudra, Yuan J Rao, Dinesh Thotala, Dennis Hallahan, Jiayi Huang
Prolonged severe lymphopenia has been shown to persist beyond a year in glioma patients after radiation therapy (RT) with concurrent and adjuvant chemotherapy. This study examines the differential impact of concurrent versus adjuvant chemotherapy on lymphopenia after RT. WHO grade II-III glioma patients who received RT with concurrent and/or adjuvant chemotherapy from 2007 to 2016 were retrospectively analyzed. Concurrent chemotherapy was temozolomide (TMZ), and adjuvant chemotherapy was either TMZ or procarbazine/lomustine/vincristine (PCV)...
November 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29143922/pre-treatment-lymphopenia-and-indication-of-tumor-induced-systemic-immunosuppression-in-medulloblastoma
#6
Seema Patel, Shiyang Wang, Matija Snuderl, Matthias A Karajannis
The presence of tumor-induced systemic immune suppression, including lymphopenia, has been recognized in adult patients with glioblastoma for several decades, and pre-treatment neutrophil-to-lymphocyte count ratio (NLCR) is associated with inferior clinical outcome in patients with glioblastoma. Whether tumor-induced systemic immune suppression is also present in children with malignant brain tumors is not known. We performed a retrospective analysis of pretreatment neutrophil and lymphocyte counts in pediatric patients with medulloblastoma (MB) compared to a control group of children with posterior fossa pilocytic astrocytoma (PA)...
November 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29143921/dichloroacetate-induced-intracellular-acidification-in-glioblastoma-in-vivo-detection-using-aacid-cest-mri-at-9-4%C3%A2-tesla
#7
Mohammed Albatany, Alex Li, Susan Meakin, Robert Bartha
Intracellular pH (pHi) plays an important role in the maintenance of normal cell function, and is maintained within a narrow range by the activity of transporters located at the plasma membrane. Modulation of tumor pHi may influence proliferation, apoptosis, chemotherapy resistance, and thermosensitivity. Chemical exchange saturation transfer (CEST) is a novel MRI contrast mechanism that is dependent on cellular pH. Amine and amide concentration-independent detection (AACID) is a recently developed CEST contrast method that is intracellular pH (pHi) weighted...
November 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29143277/myo-inositol-concentration-in-mr-spectroscopy-for-differentiating-high-grade-glioma-from-primary-central-nervous-system-lymphoma
#8
Hiroaki Nagashima, Takashi Sasayama, Kazuhiro Tanaka, Katsusuke Kyotani, Naoko Sato, Masahiro Maeyama, Masaaki Kohta, Junichi Sakata, Yusuke Yamamoto, Kohkichi Hosoda, Tomoo Itoh, Ryohei Sasaki, Eiji Kohmura
It is sometimes difficult to distinguish gliomas from other tumors on routine imaging. In this study, we assessed whether 3-T magnetic resonance spectroscopy (MRS) with LCModel software might be useful for discriminating glioma from other brain tumors, such as primary central nervous system lymphomas (PCNSLs) and metastatic tumors. A total of 104 cases of brain tumor (66 gliomas, 20 PCNSLs, 6 metastatic tumors, 12 other tumors) were preoperatively investigated with short echo time (35 ms) single-voxel 3-T MRS...
November 15, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29143276/long-term-impact-of-temozolomide-on-1p-19q-codeleted-low-grade-glioma-growth-kinetics
#9
C Izquierdo, A Alentorn, A Idbaih, M Simó, G Kaloshi, D Ricard, M Barritault, D Meyronet, J Bruna, J Honnorat, J Y Delattre, F Ducray
Although upfront temozolomide (TMZ) has been widely-used to treat 1p/19q-codeleted diffuse low-grade gliomas (LGG), its long-term impact on the growth kinetics of these tumors has not been determined. Based on serial magnetic resonance images we retrospectively evaluated the evolution of the mean tumor diameter (MTD) in 36 progressive 1p/19q-codeleted LGG treated with upfront TMZ. After TMZ onset, all but two patients (94.4%) presented a progressive MTD decrease that lasted for a median duration of 23 months (range 3-114)...
November 15, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29143275/increasing-time-to-postoperative-stereotactic-radiation-therapy-for-patients-with-resected-brain-metastases-investigating-clinical-outcomes-and-identifying-predictors-associated-with-time-to-initiation
#10
Mehran B Yusuf, Mark J Amsbaugh, Eric Burton, Megan Nelson, Brian Williams, Maria Koutourousiou, Haring Nauta, Shiao Woo
We sought to determine the impact of time to initiation (TTI) of post-operative radiosurgery on clinical outcomes for patients with resected brain metastases and to identify predictors associated with TTI. All patients with resected brain metastases treated with postoperative SRS or fractionated stereotactic radiation therapy (fSRT) from 2012 to 2016 at a single institution were reviewed. TTI was defined as the interval from resection to first day of radiosurgery. Receiver operating characteristic (ROC) curves were used to identify an optimal threshold for TTI with respect to local failure (LF)...
November 15, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29143274/clinical-features-surgical-management-and-prognostic-factors-of-secretory-meningiomas-a-single-center-case-series-of-149-patients
#11
Xiaogang Tao, Kun Wang, Jinqian Dong, Zonggang Hou, Zhen Wu, Junting Zhang, Baiyun Liu
Secretory meningioma (SM) is a rare histological subtype of the meningioma family. Few reports investigating SM have been published due to its extremely low incidence; thus, the current understanding of this disease is poor. We analyzed the incidence and clinical, radiological, pathological, and prognostic features of SM. Approximately 12,380 intracranial meningiomas were surgically resected at Beijing Tiantan Hospital between April 2008 and January 2017. All pathologically confirmed SM cases were identified...
November 15, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29143273/meningioma-recurrence-rates-following-treatment-a-systematic-analysis
#12
Victor Lam Shin Cheung, Albert Kim, Arjun Sahgal, Sunit Das
Recurrence rates of meningiomas have been widely reported in the literature, but it remains challenging for clinicians to predict recurrence rate depending on treatment, patient demographics and tumor characteristics. To address these needs, we performed a systematic analysis of the literature to determine the recurrence rate ranges of meningiomas following surgery or radiation. Our search yielded 13 studies that met all criteria for inclusion, allowing us to include 1539 patients in the assessment. Recurrence rates ranged from 0...
November 15, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29143272/preliminary-results-of-immune-modulating-antibody-mdv9300-pidilizumab-treatment-in-children-with-diffuse-intrinsic-pontine-glioma
#13
Iris Fried, Alex Lossos, Tal Ben Ami, Rina Dvir, Helen Toledano, Myriam Weil Ben Arush, Sergei Postovski, Abed Abu Kuidar, Michal Yalon, Michael Weintraub, Mony Benifla
Diffuse intrinsic pontine glioma (DIPG) is an incurable disease with a median overall survival of 10 months. Immune modulating antibodies have recently emerged as a highly promising treatment modality in multiple cancer types. We present results from the first study to evaluate the immune modulating antibody MDV9300 (pidilizumab) in pediatric patients with DIPG. All patients aged 3 years and older, diagnosed with DIPG between February 2014 and June 2015 in Israel, were offered to participate in the study...
November 15, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29139096/the-modified-frailty-index-and-30-day-adverse-events-in-oncologic-neurosurgery
#14
Brett E Youngerman, Alfred I Neugut, Jingyan Yang, Dawn L Hershman, Jason D Wright, Jeffrey N Bruce
The modified frailty index (mFI) is emerging as a leading measure for preoperative risk assessment using routinely available medical record data. Our objective was to determine if mFI predicts morbidity and mortality in the diverse national cohort of patients undergoing neurosurgery for intracranial neoplasms. We identified patients in the National Surgical Quality Improvement Program who underwent oncologic neurosurgery procedures between 2008 and 2012. The mFI, ranging from 0 to 1, was calculated as the proportion of 11 possible risk factors present...
November 14, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29139095/local-alkylating-chemotherapy-applied-immediately-after-5-ala-guided-resection-of-glioblastoma-does-not-provide-additional-benefit
#15
William Sage, Mathew Guilfoyle, Catriona Luney, Adam Young, Rohitashwa Sinha, Donatella Sgubin, Joseph H McAbee, Ruichong Ma, Sarah Jefferies, Rajesh Jena, Fiona Harris, Kieren Allinson, Tomasz Matys, Wendi Qian, Thomas Santarius, Stephen Price, Colin Watts
Grade IV glioma is the most common and aggressive primary brain tumour. Gross total resection with 5-aminolevulinic acid (5-ALA) guided surgery combined with local chemotherapy (carmustine wafers) is an attractive treatment strategy in these patients. No previous studies have examined the benefit carmustine wafers in a treatment programme of 5-ALA guided resection followed by a temozolomide-based chemoradiotherapy protocol. The objective of this study was to examine the benefit of carmustine wafers on survival in patients undergoing 5-ALA guided resection...
November 14, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29124650/correction-to-which-elderly-newly-diagnosed-glioblastoma-patients-can-benefit-from-radiotherapy-and-temozolomide-a-perno-prospective-study
#16
Enrico Franceschi, Roberta Depenni, Alexandro Paccapelo, Mario Ermani, Marina Faedi, Carmelo Sturiale, Maria Michiara, Franco Servadei, Giacomo Pavesi, Benedetta Urbini, Anna Pisanello, Girolamo Crisi, Michele A Cavallo, Claudio Dazzi, Claudia Biasini, Federica Bertolini, Claudia Mucciarini, Giuseppe Pasini, Agostino Baruzzi, Alba A Brandes
The members of the PERNO Study Group were not individually captured in the metadata of the original publication. They are included in the metadata of this publication.
November 9, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29124649/angiotensin-receptor-blockade-a-novel-approach-for-symptomatic-radiation-necrosis-after-stereotactic-radiosurgery
#17
Mudit Chowdhary, Derick Okwan-Duodu, Jeffrey M Switchenko, Robert H Press, Jaymin Jhaveri, Zachary S Buchwald, Jim Zhong, Bhavana V Chapman, Ranjit S Bindra, Joseph N Contessa, Henry S Park, James B Yu, Roy H Decker, Jeffrey J Olson, Nelson M Oyesiku, Ross A Abrams, Hui-Kuo G Shu, Walter J Curran, Ian R Crocker, Kirtesh R Patel
Preclinical evidence suggests angiotensin blockade therapy (ABT) decreases late radiation toxicities. This study aims to investigate the association between ABT and symptomatic radiation necrosis (SRN) following stereotactic radiosurgery (SRS). Resected brain metastases (rBM) and arteriovenous malformation (AVM) patients treated with SRS from 2002 to 2015 were identified. Patients in the ABT cohort were on therapy during SRS and at 1-month follow up. Kaplan Meier method and cumulative incidence model were used to analyze overall survival (OS) and intracranial outcomes...
November 9, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29119424/health-literacy-assessment-in-adults-with-neurofibromatosis-electronic-and-short-form-measurement-using-fcchl-and-health-litt
#18
Vanessa L Merker, Sarah McDannold, Eric Riklin, Mojtaba Talaei-Khoei, Monica R Sheridan, Justin T Jordan, Scott R Plotkin, Ana-Maria Vranceanu
Determining health literacy level is an important prerequisite for effective patient education. We assessed multiple dimensions of health literacy and sociodemographic predictors of health literacy in patients with neurofibromatosis. In 86 individuals with a confirmed diagnosis of neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), or schwannomatosis, we assessed health literacy status using two HL tools-the adapted functional, communicative, and critical health literacy scale (adapted FCCHL) and health literacy assessment using talking touchscreen technology (Health LiTT)...
November 8, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29119423/meningioma-and-breast-cancer-survival-of-patients-with-synchronous-and-metachronous-meningioma-and-breast-cancer
#19
José Pedro Lavrador, Marta Valente Pinto, Luís Mascarenhas Lemos, Catarina Ribeiro, André Peralta Santos
The prognosis of the association between Breast Cancer (BC) and Meningioma (M) is unknown. To evaluate the survival impact of tumor exposure sequence in patients with both tumors. Patients were divided in groups according to the tumors sequence: BC before M (group 1), synchronous BC + M (group 2) and BC after M (group 3). The SEER database was used. Demographics, meningioma and breast cancer variables were analyzed. The primary outcome was oncological survival. A total of 1715 patients were included (median follow-up:84 months)...
November 8, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29116485/prevalence-risk-factors-and-response-to-treatment-for-hypersomnia-of-central-origin-in-survivors-of-childhood-brain-tumors
#20
Raja B Khan, Thomas E Merchant, Zsila S Sadighi, Mercedes S Bello, Zhaohua Lu, April Sykes, Merrill S Wise, Valerie M Crabtree, Jennifer Zabrowski, Andrea Simmons, Mary E Clark, Belinda N Mandrell
Daytime sleepiness is recognized in childhood brain tumor survivors. Our objective was to determine prevalence, risk factors for PSG/MLST proven hypersomnia/narcolepsy, and response to stimulants in childhood brain tumor survivors. Standard PSG/MSLT criteria were used to diagnose hypersomnia/narcolepsy. Medical records of brain tumor survivors having undergone a PSG/MSLT were reviewed for the diagnostic code of hypersomnia/narcolepsy. Survivors with hypersomnia/narcolepsy were matched with 2-3 survivors without reported hypersomnia/narcolepsy by age at tumor diagnosis, gender, and time from tumor diagnosis...
November 8, 2017: Journal of Neuro-oncology
journal
journal
28661
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"