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Advances in Biochemical Engineering/biotechnology

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https://www.readbyqxmd.com/read/30397726/engineering-of-yeast-glycoprotein-expression
#1
Charlot De Wachter, Linde Van Landuyt, Nico Callewaert
Yeasts are valuable hosts for recombinant protein production, as these unicellular eukaryotes are easy to handle, grow rapidly to a high cell density on cost-effective defined media, often offer a high space-time yield, and are able to perform posttranslational modifications. However, a key difference between yeasts and mammalian cells involves the type of glycosylation structures, which hampers the use of yeasts for the production of many biopharmaceuticals. Glycosylation is not only important for the folding process of most recombinant proteins; it has a large impact on pharmacokinetics and pharmacodynamics of the therapeutic proteins as well...
November 7, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/30270411/green-chemistry-and-its-contribution-to-industrial-biotechnology
#2
Daniel Pleissner, Klaus Kümmerer
Sustainable chemistry is a broad framework that starts with the function that a chemical product is offering. Not only chemical but also economic and ethical aspects come into focus throughout the complete lifecycle of chemical products. Green chemistry is an important building block for sustainable chemistry and addresses the issue of greener synthesis and, to a certain degree, the more benign properties of chemicals. The principles of green chemistry clearly aim at making chemical reactions and processes more environmentally friendly...
October 1, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/30267102/electrification-of-biotechnology-quo-vadis
#3
Dirk Holtmann, Falk Harnisch
Electrobiotechnology has come a long way and has gained much interest among researchers all over the world. In the previous chapters of this book, an abundance of successful developments of lab-scale electrobiosynthesis and their underlying fundamentals are described. Thereby the individual needs and lines of research are highlighted. In this final chapter we will try to shed light on the overall performance of electrobiosynthetic processes with regard to their technological maturity, as well as the potential ecological and economic incentives for their industrial implementation...
September 29, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/30244300/risk-assessment-of-processes-and-products-in-industrial-biotechnology
#4
Chao Chen, Genserik Reniers
Risk assessment has been used extensively as the main approach to prevent accidents in the chemical and process industry. Industrial biotechnology has many of the same hazards as chemical technology, but also encounters biological hazards related to biological agents. Employees in the biotechnology industry are susceptible to health risks because of different types of exposure to harmful agents. The external environment may also be affected by these agents in cases of accidental release. This chapter first presents several traditional risk assessment methods that may be used in industrial biotechnology after comparing differences between industrial biotechnology and chemical technology...
September 23, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/30242432/biopolymer-based-composite-materials-prepared-using-ionic-liquids
#5
Saerom Park, Kyeong Keun Oh, Sang Hyun Lee
Biopolymer-based composite materials have many potential applications in biomedical, pharmaceutical, environmental, biocatalytic, and bioelectronic fields, owing to their inherent biocompatibility and biodegradability. When used as solvents, ionic liquids can be used to fabricate biopolymers such as polysaccharides and proteins into various forms, including molded shapes, films, fibers, and beads. This article summarizes the processes for preparing biopolymer-based composite materials using ionic liquids. The processes include biopolymer dissolution using ionic liquids, regeneration of the biopolymer by an anti-solvent, formation of shapes, and drying of the regenerated biopolymer...
September 22, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/30143807/interplay-of-carbohydrate-and-carrier-in-antibacterial-glycoconjugate-vaccines
#6
Tyler D Moeller, Kevin B Weyant, Matthew P DeLisa
Bacterial infections are a serious health concern and are responsible for millions of illnesses and deaths each year in communities around the world. Vaccination is an important public health measure for reducing and eliminating this burden, and regions with comprehensive vaccination programs have achieved significant reductions in infection and mortality. This is often accomplished by immunization with bacteria-derived carbohydrates, typically in conjunction with other biomolecules, which induce immunological memory and durable protection against bacterial human pathogens...
August 25, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/30099598/bacterial-glycoengineering-as-a-biosynthetic-route-to-customized-glycomolecules
#7
Laura E Yates, Dominic C Mills, Matthew P DeLisa
Bacteria have garnered increased interest in recent years as a platform for the biosynthesis of a variety of glycomolecules such as soluble oligosaccharides, surface-exposed carbohydrates, and glycoproteins. The ability to engineer commonly used laboratory species such as Escherichia coli to efficiently synthesize non-native sugar structures by recombinant expression of enzymes from various carbohydrate biosynthesis pathways has allowed for the facile generation of important products such as conjugate vaccines, glycosylated outer membrane vesicles, and a variety of other research reagents for studying and understanding the role of glycans in living systems...
August 12, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/30094602/synthesis-of-ionic-liquids-originated-from-natural-products
#8
Hiroyuki Ohno
In this chapter, preparation, basic properties, and some applications of ionic liquids composed of naturally-derived ions are summarized. There are many candidate ions in nature suitable for ionic liquid preparation. Physicochemical properties and preparation of some ionic liquids based on carboxylate anions, cholinium cation, and even amino acids are mentioned. Some interesting applications based on these ionic liquids composed of naturally-derived ions are also briefly introduced. Graphical Abstract.
August 10, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/30069741/glyco-engineering-of-plant-based-expression-systems
#9
Rainer Fischer, Tanja Holland, Markus Sack, Stefan Schillberg, Eva Stoger, Richard M Twyman, Johannes F Buyel
Most secreted proteins in eukaryotes are glycosylated, and after a number of common biosynthesis steps the glycan structures mature in a species-dependent manner. Therefore, human therapeutic proteins produced in plants often carry plant-like rather than human-like glycans, which can affect protein stability, biological function, and immunogenicity. The glyco-engineering of plant-based expression systems began as a strategy to eliminate plant-like glycans and produce human proteins with authentic or at least compatible glycan structures...
August 2, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/30046916/economic-aspects-of-industrial-biotechnology
#10
Gunter Festel
Industrial biotechnology is a key tool in the switch from a petro-based to a bio-based economy. For biotechnological processes to compete competitively in cost with chemical synthesis, the best available state-of-the-art technologies are necessary. In the last few years, industrial biotechnology has undergone fast technological development, resulting in a high number of basic technologies emanating from research efforts at universities and research institutions. Academic spin-offs have great importance in technological development because of their innovation from academic backgrounds...
July 26, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/30003282/ionic-liquids-as-stabilization-and-refolding-additives-and-solvents-for-proteins
#11
Kyoko Fujita
This chapter focuses on recent advances in the use of ionic liquids as additives and solvents in protein applications. The solvent properties of ionic liquids can be tuned by the appropriate selection of cation and anion. The effects of different kinds of ionic liquids on protein stability and refolding behavior have been investigated and reported. The ionic liquid properties affect the intermolecular interactions of proteins, inducing different formations and folding behavior. These effects also vary with the concentration of ionic liquids...
July 13, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29934794/logistics-of-lignocellulosic-feedstocks-preprocessing-as-a-preferable-option
#12
Nils Tippkötter, Sophie Möhring, Jasmine Roth, Helene Wulfhorst
In comparison to crude oil, biorefinery raw materials are challenging in concerns of transport and storage. The plant raw materials are more voluminous, so that shredding and compacting usually are necessary before transport. These mechanical processes can have a negative influence on the subsequent biotechnological processing and shelf life of the raw materials. Various approaches and their effects on renewable raw materials are shown. In addition, aspects of decentralized pretreatment steps are discussed...
June 23, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29886511/glycobiotechnology-of-the-insect-cell-baculovirus-expression-system-technology
#13
Laura A Palomares, Indresh K Srivastava, Octavio T Ramírez, Manon M J Cox
The insect cell-baculovirus expression system technology (BEST) has a prominent role in producing recombinant proteins to be used as research and diagnostic reagents and vaccines. The glycosylation profile of proteins produced by the BEST is composed predominantly of terminal mannose glycans, and, in Trichoplusia ni cell lines, core α3 fucosylation, a profile different to that in mammals. Insects contain all the enzymatic activities needed for complex N- and O-glycosylation and sialylation, although few reports of complex glycosylation and sialylation by the BEST exist...
June 10, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29796878/natural-deep-eutectic-solvents-and-their-applications-in-biotechnology
#14
Zhen Yang
Following the appearance of ionic liquids (ILs) and deep eutectic solvents (DESs), natural deep eutectic solvents (NADESs) have emerged as a new type of truly green solvents with many excellent advantages such as cheapness, sustainability, biocompatibility, environmental friendliness, and, in particular, remarkable solubilizing power and outstanding designability. Although only at an early stage, research on NADESs has started to blossom with exponential growth, showing attractive and promising potentials for applications in various areas...
May 24, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29748871/an-introduction-to-recent-trends-in-the-biotechnology-industry-development-and-manufacturing-of-recombinant-antibodies-and-proteins
#15
Michael Pohlscheidt, Robert Kiss, Uwe Gottschalk
The production of the first therapeutic proteins in the early 1980s heralded the launch of the biopharmaceuticals industry. The number of approved products has grown year on year over the past three decades to now represent a significant share of the entire pharmaceuticals market. More than 200 therapeutic proteins have been approved, approximately a quarter of which are represented by monoclonal antibodies and their derivatives. In 2016, the list of the top 15 best-selling drugs included more than eight biologics and in 2020 the trend will continue, with more than 50% of the top 20 best-selling drugs predicted to be biologics...
May 11, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29744544/ionic-liquids-in-bioseparation-processes
#16
Diana C V Belchior, Iola F Duarte, Mara G Freire
Bioseparation processes are a relevant part of modern biotechnology, particularly regarding the development of efficient and biocompatible methods for the separation and purification of added-value biologically active compounds. In this field, ionic liquids (ILs) have been proposed, either in liquid-liquid extractions, in which non-water miscible ILs or aqueous biphasic systems (ABS) formed by ILs can be used, or in solid-liquid extractions, in which they are covalently attached to create supported IL phases (SILPs)...
May 10, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29744543/advances-in-processing-chitin-as-a-promising-biomaterial-from-ionic-liquids
#17
Julia L Shamshina, Oleksandra Zavgorodnya, Robin D Rogers
Chitin isolated through microwave-assisted dissolution using ionic liquids is a high molecular weight (MW) polymer that can be manufactured into materials of different architectures (e.g., fibers, films, microspheres, nanostructured materials) to be used as wound care dressings, drug delivery devices, scaffolds, etc. However, because of differences from traditional isolation methods and, thus, differences in polymer length and degree of deacetylation, it could exhibit bio-related properties that differ from those of traditionally 'pulped' chitin...
May 10, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29744542/ionic-liquid-pretreatment-of-lignocellulosic-biomass-for-enhanced-enzymatic-delignification
#18
Muhammad Moniruzzaman, Masahiro Goto
Ionic liquids (ILs), a potentially attractive "green," recyclable alternative to environmentally harmful volatile organic compounds, have been increasingly exploited as solvents and/or cosolvents and/or reagents in a wide range of applications, including pretreatment of lignocellulosic biomass for further processing. The enzymatic delignification of biomass to degrade lignin, a complex aromatic polymer, has received much attention as an environmentally friendly process for clean separation of biopolymers including cellulose and lignin...
May 10, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29744541/activation-of-lipase-catalyzed-reactions-using-ionic-liquids-for-organic-synthesis
#19
Toshiyuki Itoh
The use of ionic liquids to replace organic or aqueous solvents in biocatalysis processes has recently received great attention, and much progress has been made in this area; the lipase-catalyzed reactions are the most successful. Recent developments in the application of ionic liquids as solvents in lipase-catalyzed reactions for organic synthesis are reviewed, focusing on the ionic liquid mediated activation method of lipase-catalyzed reactions.
May 10, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29721583/a-different-perspective-how-much-innovation-is-really-needed-for-monoclonal-antibody-production-using-mammalian-cell-technology
#20
Brian Kelley, Robert Kiss, Michael Laird
As biopharmaceutical companies have optimized cell line and production culture process development, titers of recombinant antibodies have risen steadily to 3-8 g/L for fed-batch mammalian cultures at production scales of 10 kL or larger. Most new antibody products are produced from Chinese Hamster Ovary (CHO) cell lines, and there are relatively few alternative production hosts under active evaluation. Many companies have adopted a strategy of using the same production cell line for early clinical phases as well as commercial production, which reduces the risk of product comparability issues during the development lifecycle...
May 3, 2018: Advances in Biochemical Engineering/biotechnology
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