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World Journal of Urology

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https://www.readbyqxmd.com/read/29905887/intravesical-bcg-treatment-causes-a-long-lasting-reduction-of-recurrence-and-progression-in-patients-with-high-risk-non-muscle-invasive-bladder-cancer
#1
Tomas Thiel, Charlotta Ryk, Lotta Renström-Koskela, Gunnar Steineck, Martin C Schumacher, N Peter Wiklund, Petra J de Verdier
PURPOSE: To analyse if BCG treatment leads to long-term reduction of recurrence, progression, and cancer-specific mortality (CSM) in patients with high-risk NMIBC. MATERIALS AND METHODS: 140 patients with high-risk NMIBC were drawn from a population-based cohort of 538 patients with newly diagnosed bladder cancer in the Stockholm County between 1995 and 1996. Data were collected prospectively, and a final follow-up for recurrence, progression, and CSM was performed after 15 years...
June 15, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29882105/concomitant-cis-on-turbt-does-not-impact-oncological-outcomes-in-patients-treated-with-neoadjuvant-or-induction-chemotherapy-followed-by-radical-cystectomy
#2
N Vasdev, H Zargar, J P Noël, R Veeratterapillay, A S Fairey, L S Mertens, C P Dinney, M C Mir, L M Krabbe, M S Cookson, N E Jacobsen, N M Gandhi, J Griffin, J S Montgomery, E Y Yu, E Xylinas, N J Campain, W Kassouf, M A Dall'Era, J A Seah, C E Ercole, S Horenblas, S S Sridhar, J S McGrath, J Aning, S F Shariat, J L Wright, T M Morgan, T J Bivalacqua, S North, D A Barocas, Y Lotan, P Grivas, A J Stephenson, J B Shah, B W van Rhijn, S Daneshmand, P E Spiess, J M Holzbeierlein, A Thorpe, P C Black
BACKGROUND: Cisplatin-based neoadjuvant chemotherapy (NAC) for muscle invasive bladder cancer improves all-cause and cancer specific survival. We aimed to evaluate whether the detection of carcinoma in situ (CIS) at the time of initial transurethral resection of bladder tumor (TURBT) has an oncological impact on the response to NAC prior to radical cystectomy. PATIENTS AND METHODS: Patients were identified retrospectively from 19 centers who received at least three cycles of NAC or induction chemotherapy for cT2-T4aN0-3M0 urothelial carcinoma of the bladder followed by radical cystectomy between 2000 and 2013...
June 7, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29876671/validating-the-role-of-abo-blood-type-in-risk-of-perioperative-venous-thromboembolism-after-radical-cystectomy
#3
Sumeet Bhanvadia, Kayvan Kazerouni, Soroush T Bazargani, Gus Miranda, Jie Cai, Siamak Daneshmand, Hooman Djaladat
PURPOSE: To validate the relationship between ABO blood type and risk of VTE post-RC in a large retrospective database. METHODS: Patients with urothelial bladder cancer (UBC) who underwent RC (intent-to-cure) for whom ABO blood type was available between 2003 and 2015 were identified from our IRB-approved database. VTE was defined as deep vein thrombosis (DVT) or pulmonary embolism (PE) within 90 days of surgery. VTE prophylaxis consisted of immediate postoperative Coumadin (2003-2009), unfractionated heparin (UFH) during hospitalization (2009-2015), and UFH during hospitalization plus 4 weeks of enoxaparin after discharge (2013-2015)...
June 6, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29872900/is-urodynamics-necessary-to-identify-occult-stress-urinary-incontinence
#4
Susane Mei Hwang, Luís Gustavo Morato de Toledo, Silvia da Silva Carramão, Armando Brites Frade, Andre Costa Matos, Antonio Pedro Flores Auge
PURPOSE: To investigate Occult Stress Urinary Incontinence (OSUI) using physical exam (PE) and urodynamics (UDS) in women with advanced pelvic organ prolapse (POP), and compare the two methods. METHODS: This study comprised 105 women with POP stage-III and -IV, according to POP quantification (POP-Q) system, evaluated prospectively between January and December 2015. A standard history, an incontinence questionnaire and PE were completed before the investigation of the OSUI that was performed in the supine and standing positions, reducing the prolapse using gauze and Cheron dressing forceps...
June 5, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29869701/single-use-versus-reusable-ureterorenoscopes-for-retrograde-intrarenal-surgery-rirs-systematic-comparative-analysis-of-physical-and-optical-properties-in-three-different-devices
#5
Susanne Deininger, Luis Haberstock, Stephan Kruck, Eva Neumann, Ines Anselmo da Costa, Tilman Todenhöfer, Jens Bedke, Arnulf Stenzl, Steffen Rausch
INTRODUCTION: Retrograde intrarenal surgery (RIRS) represents a standard option for kidney stone removal. However, RIRS is considered a cost-intensive procedure. Single-use flexible ureterorenoscopes have been introduced to improve budget predictability in RIRS. We assessed differences in physical and optical properties of single-use devices compared to standard reusable endoscopes. METHODS: In two single-use (LithoVue™, Boston Scientific; Pusen Uscope UE3011™), and one reusable ureterorenoscope (Flex-Xc™, Karl Storz), we investigated flow rates, deflection, illuminance, and intrapelvic pressure in a porcine kidney model...
June 5, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29860605/immune-phenotype-of-peripheral-blood-mononuclear-cells-in-patients-with-high-risk-non-muscle-invasive-bladder-cancer
#6
François Audenet, Adam M Farkas, Harry Anastos, Matthew D Galsky, Nina Bhardwaj, John P Sfakianos
PURPOSE: To explore the immune phenotype of peripheral blood mononuclear cells (PBMC) in patients with high-risk non-muscle invasive bladder cancer (NMIBC). METHODS: We prospectively collected blood samples from patients with high-risk NMIBC treated at our institution. PBMC were analyzed by flow cytometry to determine the frequency of T cells and NK cells and the expression of immunoregulatory molecules (Tim-3, TIGIT and PD-1). PBMC from healthy donors (HD) were included for comparison, and associations with response to BCG were investigated...
June 2, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29858701/epidemiology-biology-and-treatment-of-sarcomatoid-rcc-current-state-of-the-art
#7
REVIEW
Cedric Lebacle, Aydin Pooli, Thomas Bessede, Jacques Irani, Allan J Pantuck, Alexandra Drakaki
Long recognized to confer an extremely poor prognosis, sarcomatoid dedifferentiation of renal cell carcinoma (sRCC) is a tumor phenotype that is finally beginning to be better understood on the molecular and genetic levels. With an overall incidence that ranges from 1 to 32% depending on associated RCC subtype, the survival of sarcomatoid RCC patients rarely exceeds 2 years. The main reasons for its poor outcome include its aggressive biology, its tendency to present at an advanced or metastatic stage at the time of diagnosis, its high rate of tumor recurrence after nephrectomy, and its limited response to systemic therapies...
June 1, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29858700/holep-provides-a-higher-prostate-cancer-detection-rate-compared-to-bipolar-turp-a-matched-pair-analysis
#8
Bernd Rosenhammer, Eva M Lausenmeyer, Roman Mayr, Maximilian Burger, Christian Eichelberg
PURPOSE: Holmium laser enucleation of the prostate (HoLEP) has become a popular alternative to TURP for desobstructive prostate surgery. The prevalence of incidental prostate cancer (iPCa) during surgery varies depending on many preoperative factors. To evaluate whether the surgical procedure itself (HoLEP vs. TURP) influences iPCa detection, we performed a case-by-case matched-pair analysis. METHODS: Preoperative patient age, total PSA, and prostate volume were used as matching criteria...
June 1, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29858699/author-reply-letter-to-editor-on-the-effect-of-corticosteroid-on-postoperative-early-pain-renal-colic-and-total-analgesic-consumption-after-uncomplicated-and-unstented-ureteroscopy-a-matched-pair-analysis-by-mark-c-kendall
#9
LETTER
https://www.readbyqxmd.com/read/29855698/development-of-immunotherapy-in-bladder-cancer-present-and-future-on-targeting-pd-l-1-and-ctla-4-pathways
#10
REVIEW
Mathieu Rouanne, Mathieu Roumiguié, Nadine Houédé, Alexandra Masson-Lecomte, Pierre Colin, Géraldine Pignot, Stéphane Larré, Evanguelos Xylinas, Morgan Rouprêt, Yann Neuzillet
PURPOSE: Over the past 3 decades, no major treatment breakthrough has been reported for advanced bladder cancer. Recent Food and Drug Administration (FDA) approval of five immune checkpoint inhibitors in the management of advanced bladder cancer represent new therapeutic opportunities. This review examines the available data of the clinical trials leading to the approval of ICIs in the management of metastatic bladder cancer and the ongoing trials in advanced and localized settings. METHODS: A literature search was performed on PubMed and ClinicalTrials...
June 1, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29855697/patients-with-disorders-of-sex-development-and-proximal-hypospadias-are-at-high-risk-for-reoperation
#11
Amanda F Saltzman, Alonso Carrasco, Alexandra Colvin, Jeffrey B Campbell, Vijaya M Vemulakonda, Duncan Wilcox
PURPOSE: Surgical repair for proximal hypospadias has been associated with long-term success rates of 32-68%. In a prior study, outcomes for proximal hypospadias in patients with a diagnosis of disorders of sex development (DSD) were no different than those of patients without DSD. The objective of our study is to report our experience with proximal hypospadias repair in patients with and without DSD. METHODS: We retrospectively reviewed patients who underwent repair of proximal hypospadias between 2005 and 2016...
May 31, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29845320/surveillance-and-management-of-urologic-complications-after-spinal-cord-injury
#12
Evgeniy Kreydin, Blayne Welk, Doreen Chung, Quentin Clemens, Claire Yang, Teresa Danforth, Angelo Gousse, Stephanie Kielb, Stephen Kraus, Altaf Mangera, Sheilagh Reid, Nicole Szell, Francisco Cruz, Emmanuel Chartier-Kastler, David A Ginsberg
PURPOSE: Neurogenic bladder due to spinal cord injury has significant consequences for patients' health and quality of life. Regular surveillance is required to assess the status of the upper and lower urinary lower urinary tracts and prevent their deterioration. In this review, we examine surveillance techniques in neurogenic bladder, describe common complications of this disease, and address strategies for their management. METHODS: This work represents the efforts of SIU-ICUD joint consultation on Urologic Management of the Spinal Cord injury...
May 29, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29845319/advanced-non-contrasted-computed-tomography-post-processing-by-ct-calculometry-ct-cm-outperforms-established-predictors-for-the-outcome-of-shock-wave-lithotripsy
#13
J Langenauer, P Betschart, L Hechelhammer, S Güsewell, H P Schmid, D S Engeler, D Abt, V Zumstein
OBJECTIVES: To evaluate the predictive value of advanced non-contrasted computed tomography (NCCT) post-processing using novel CT-calculometry (CT-CM) parameters compared to established predictors of success of shock wave lithotripsy (SWL) for urinary calculi. MATERIALS AND METHODS: NCCT post-processing was retrospectively performed in 312 patients suffering from upper tract urinary calculi who were treated by SWL. Established predictors such as skin to stone distance, body mass index, stone diameter or mean stone attenuation values were assessed...
May 29, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29808302/early-neurological-care-of-patients-with-spinal-cord-injury
#14
Thomas M Kessler, Luca R Traini, Blayne Welk, Marc P Schneider, Jeffrey Thavaseelan, Armin Curt
PURPOSE: Considering the major clinical challenges of managing patients with spinal cord injury (SCI), we summarized the relevant aspects of the early (within 1 year after SCI) neurological care emphasizing common standards. METHODS: This review was performed according to the methodology recommended by the Joint SIU-ICUD International Consultation. Embase and Medline databases were used to identify literature relevant to the early neurological care of SCI patients...
May 28, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29808301/the-role-of-mpmri-and-psa-density-in-patients-with-an-initial-negative-prostatic-biopsy
#15
Ahmed Fouad Kotb, Shelley Spaner, Trafford Crump, Matthew Eric Hyndman
INTRODUCTION: While an elevated PSA significantly increases the risk of men harboring prostate cancer, many men with a persistently elevated PSA have negative prostate biopsies. More recently, multiparametric MRI (mpMRI) has had promising implications for the diagnosis of prostate cancer. We aim to investigate the diagnostic role of mpMRI in predicting the future diagnosis of prostate cancer in patients with an initial negative biopsy. METHODS: This study included all men with negative biopsies, elevated PSA and mpMRI...
May 28, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29808300/catch-22-a-manual-bladder-washout-protocol-to-improve-care-for-clot-retention
#16
Emma Clarebrough, Shannon McGrath, Daniel Christidis, Nathan Lawrentschuk
PURPOSE: To review current practices in manual bladder washouts (MBW) for haematuria with clot retention, comparing those conducted by a urology unit to other inpatient services. Secondly, to describe a standardised protocol for MBWs. METHODS: Prospective data were collected for patients treated for clot retention, from initial management by referral units through to implementation of a standardised MBW by the urology service. Outcomes measured included re-catheterisation, MBW volumes, clot evacuated and time to discharge or subsequent intervention...
May 28, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29804202/salvage-topical-therapy-for-upper-tract-urothelial-carcinoma
#17
Adithya Balasubramanian, Michael J Metcalfe, Gavin Wagenheim, Lianchun Xiao, John Papadopoulos, Neema Navai, John W Davis, Jose A Karam, Ashish M Kamat, Christopher G Wood, Colin P Dinney, Surena F Matin
PURPOSE: Topical therapy (TT) for upper tract urothelial carcinoma (UTUC) has been explored as a kidney sparing approach to treat carcinoma in situ (CIS) and as adjuvant for endoscopically treated Ta/T1 tumors. In bladder cancer, data support use of salvage TT for repeat induction. We investigate the outcomes of salvage TT for UTUC in patients ineligible for or refusing nephroureterectomy. METHODS: A single-center retrospective review on patients receiving salvage TT via percutaneous nephrostomy tube or cystoscopically placed ureteral catheters was performed...
May 26, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29802428/medical-impulsive-therapy-mit-the-impact-of-1-week-of-preoperative-tamsulosin-on-deployment-of-16-french-ureteral-access-sheaths-without-preoperative-ureteral-stent-placement
#18
Kamaljot S Kaler, Shoaib Safiullah, Daniel J Lama, Egor Parkhomenko, Zhamshid Okhunov, Young H Ko, Linda Huynh, Roshan M Patel, Jaime Landman, Ralph V Clayman
INTRODUCTION AND OBJECTIVES: Medical expulsive therapy is based on pharmacologic ureteral relaxation. We hypothesized this concept may facilitate the deployment of the large 16 French (F) ureteral access sheath (UAS) when patients are intentionally pre-treated with oral tamsulosin, i.e., medical impulsive therapy. METHODS: We retrospectively analyzed our experience with UAS deployment during endoscopic-guided percutaneous nephrolithotomy in prone position in patients pre-treated for 1 week with oral tamsulosin with a contemporary untreated cohort...
May 25, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29796775/the-prevalence-and-risk-factors-of-nocturia-in-china-south-korea-and-taiwan-results-from-a-cross-sectional-population-based-study
#19
Po-Ming Chow, Shih-Ping Liu, Yao-Chi Chuang, Kyu-Sung Lee, Tag Keun Yoo, Limin Liao, Jian-Ye Wang, Ming Liu, Budiwan Sumarsono, Jar Jar Jong
PURPOSE: To examine the prevalence, symptomatology, and risk factors for nocturia using data from an internet-based questionnaire conducted in China, South Korea, and Taiwan. METHODS: Data from a cross-sectional, population-representative, internet-based study conducted among men and women aged ≥ 40 years were analysed post hoc. Nocturia prevalence and bother were analysed by sex and age group, and with regard to comorbid conditions and lower urinary tract symptoms (LUTS)...
May 23, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29785492/a-new-prognostic-model-for-localized-renal-cell-carcinoma
#20
LETTER
Sebastiano Buti
No abstract text is available yet for this article.
May 21, 2018: World Journal of Urology
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