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World Journal of Urology

Pia Paffenholz, Katharina Grein, Isabel Heidegger, Tim Nestler, Markus Grabbert, Johannes Salem, Martin Hellmich, David Pfister, Axel Heidenreich
PURPOSE: To identify potential risk factors for the development of venous thromboembolic events in testicular cancer patients receiving platinum-based chemotherapy. METHODS: We performed a retrospective analysis including 255 patients with testicular germ cell tumors who received platinum-based chemotherapy from 2003 to 2018 as a multi-center observational cohort study. Patient and tumor characteristics of patients with and without a thromboembolic event were analyzed...
December 13, 2018: World Journal of Urology
David J McConkey, Seth P Lerner
PURPOSE: To provide a condensed summary of the Basic Science chapter that was included in the Third International Consultation on Bladder Cancer. METHODS: World bladder cancer basic science experts used the published literature to create summaries of recent progress in their areas of expertise. RESULTS: The completion of several large-scale genomics projects coupled with a strong collaborative culture within the research community and the exciting clinical activity of immune checkpoint blockade have combined to transform the bladder cancer research landscape...
December 13, 2018: World Journal of Urology
Michael E Chua, Jonathan S Mendoza, Jessica M Ming, Jun S Dy, Odina Gomez
PURPOSE: To assess the diagnostic accuracy and safety of contrast-enhanced voiding urosonogram using second-generation contrast with harmonic imaging (CEVUS-HI) in detecting vesicoureteral reflux (VUR) among children. METHODS: A systematic literature search was performed in March 2018. Relevant comparative studies from Medline, EMBASE, World of Science, Scopus, CENTRAL, WHO trial registry and were identified and appraised using QUADAS-2. Diagnostic accuracy parameters were determined using VCUG as the reference standard...
December 12, 2018: World Journal of Urology
Chi-Shin Tseng, Ting-En Tai, Chung-Hung Hong, Chung-Hsin Chen, I-Ni Chiang, Yu-Chuan Lu, Shih-Chun Hung, Kuo-How Huang, Chao-Yuan Huang, Hong-Chiang Chang, Yeong-Shiau Pu, Po-Ming Chow
PURPOSE: To analyze the trifecta outcome (functional, anatomical, and surgical aspects) of surgical reconstruction for ureteral lesions and investigate the factors affecting the success rate of such reconstruction. METHODS: We retrospectively reviewed the data of patients who underwent ureteral reconstruction at our institute between March 2007 and November 2016. Patient profiles, surgical methods, complications, ureteral stenting, laboratory data, and image studies were collected...
December 11, 2018: World Journal of Urology
Guglielmo Mantica, Andrea Pacchetti, Roberta Aimar, Mattia Cerasuolo, Federico Dotta, Alberto Olivero, Giovannalberto Pini, Giovanni Passaretti, Massimo Maffezzini, Carlo Terrone
PURPOSE: To evaluate a five-step training model for transperineal prostate biopsies (TPPB) and the differences in terms of the detection rate (DR) and the ease of execution when using either the "fan technique" (FT) or the use of a Free Hand technique (FH). METHODS: A prospective observational randomised study was conducted from September 2015 to November 2017. Six naïve residents, who underwent the same five-steps training model, were randomly subdivided into two different groups of three residents based on the selected TPPB technique: A (FT) and B (FH)...
December 10, 2018: World Journal of Urology
Hyung Suk Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
PURPOSE: To develop and validate novel nomograms to predict recurrence and progression after transurethral resection of bladder tumor (TURBT) in Korean patients with non-muscle-invasive bladder cancer (NMIBC). METHODS: We retrospectively analyzed the clinical data on 970 newly diagnosed NMIBC patients after TURBT between 2000 and 2013 in a single institution. We used multivariate Cox proportional hazard models to identify the significant predictors of recurrence and progression, which resulted in the construction of the nomograms predicting the 5-year probability of recurrence and progression...
December 10, 2018: World Journal of Urology
Mehran Rezaei, Rozhin Badiei, Ronak Badiei
PURPOSE: Local injection of platelet-rich plasma (PRP) is postulated to work by delivering growth factors and cytokines that recruit healer cells and enhance recovery process at the injection site. As new scar formation leads to stricture recurrence after internal urethrotomy, we proposed to improve post-internal urethrotomy stricture recurrence rate by injecting local submucosal PRP at the time of urethrotomy. METHODS: From July 2015 to June 2018, 87 male patients with symptomatic bulbar urethral stricture (diagnosed by retrograde urethrography) randomized into two groups of internal urethrotomy and submucosal normal saline injection (control group, 43 patients), and internal urethrotomy with submucosal autologous platelet-rich plasma injection (PRP injection group, 44 patients)...
December 10, 2018: World Journal of Urology
Da-Wei Tian, Sheng-Lai Liu, Li-Ming Jiang, Zhou-Liang Wu, Jie Gao, Hai-Long Hu, Chang-Li Wu
BACKGROUND: Bladder cancer is the most common malignancy of urinary system with high morbidity and mortality. In general, the development and progression of bladder cancer are complicated pathological processes, and the treatment methods mainly include surgical resection, radiotherapy, chemotherapy, and combined therapy. In recent years, targeted therapy has made progress in the treatment of bladder cancer. Therefore, to improve survival rates of patients with advanced bladder cancer, novel therapeutic targets are still urgently needed...
December 10, 2018: World Journal of Urology
Charles C Peyton, Juan Chipollini, Mounsif Azizi, Ashish M Kamat, Scott M Gilbert, Phillippe E Spiess
INTRODUCTION: Intravesical therapy has been an important aspect of the management of non-muscle invasive bladder cancer (NMIBC) for 40 years. Bacillus Calmette-Guerin (BCG) is considered standard of care for intermediate and high-grade non-invasive disease, yet understanding the nuances of subsequent intravesical therapy is important for any provider managing bladder cancer. Herein, we review the literature and describe optimal use of intravesical therapies for NMIBC. METHODS: A comprehensive search of the medical literature was performed and highlighted in this review of intravesical therapy for NMIBC...
December 7, 2018: World Journal of Urology
David P Al-Adra, Maria Lambadaris, Andrew Barbas, Yanhong Li, Markus Selzner, Sunita K Singh, Olusegun Famure, S Joseph Kim, Anand Ghanekar
PURPOSE: The effect of living donor kidney allograft size on recipient outcomes is not well understood. In this study, we sought to investigate the relationship between preoperatively measured donor kidney volume and recipient estimated glomerular filtration rate (eGFR) in living donor kidney transplantation (LDKT). METHODS: We studied computed tomography (CT) donor kidney volumes and recipient outcomes for 438 LDKTs at the Toronto General Hospital between 2007 and 2016...
December 6, 2018: World Journal of Urology
Xinyang Liao, Shi Qiu, Yige Bao, Wanyu Wang, Lu Yang, Qiang Wei
PURPOSE: To compare the efficacy and safety profiles of different phosphodiesterase-5 inhibitors (PDE5Is) administrations for erectile dysfunction (ED) in diabetic men, including on-demand (PRN) and regular regimens (OAD). MATERIALS AND METHODS: Searches were carried out in four electronic databases: PubMed (until April 17th, 2017); Scopus (until April 17th, 2017); Embase (until April 17th, 2017); and Cochrane (until April 18th, 2017). The outcomes for this study are as follows: (1) Global Assessment Question (GAQ) positive response rate; (2) changes from baseline to the end of the study in Erectile Function Domain of International Index of Erectile Function (IIEF-EF); and (3) treatment-related adverse events (TRAEs)...
December 6, 2018: World Journal of Urology
Uros Milenkovic, Murat Akand, Lisa Moris, Liesbeth Demaegd, Tim Muilwijk, Youri Bekhuis, Annouschka Laenen, Ben Van Cleynenbreugel, Wouter Everaerts, Hein Van Poppel, Herlinde Dumez, Maarten Albersen, Steven Joniau
OBJECTIVES: To compare perioperative and short-term postoperative complication rates between patients receiving radical cystectomy (RC) after neoadjuvant chemotherapy (NAC) and patients undergoing RC alone. Secondary objectives were to compare overall survival (OS) and cancer-specific survival (CSS). MATERIALS AND METHODS: Clinico-pathological data of all patients who received RC between 1996 and 2015 were retrospectively collected. Only patients with RC for muscle-invasive bladder cancer were included in the final analysis...
December 5, 2018: World Journal of Urology
Maria Escolino, Lorenzo Masieri, Jean-Stephane Valla, Pedro Josè Lopez, Baran Tokar, Imran Mushtaq, Ciro Esposito
PURPOSE: This retrospective study aimed to report a multi-institutional experience with laparoscopic and robotic-assisted repair of retrocaval ureter in children and to compare outcome of minimally invasive surgery (MIS) with open repair. METHODS: The records of all children, who underwent MIS and open repair of retrocaval ureters in six international pediatric urology units over a 5-year period, were retrospectively collected. Data were grouped according to the operative approach: a laparoscopic group (G1) included five patients, a robotic-assisted group (G2) included four patients, and an open group (G3) included three patients...
December 5, 2018: World Journal of Urology
Etienne Xavier Keller, Jacqueline Bachofner, Anna Jelena Britschgi, Karim Saba, Ashkan Mortezavi, Basil Kaufmann, Christian D Fankhauser, Peter Wild, Tullio Sulser, Thomas Hermanns, Daniel Eberli, Cédric Poyet
PURPOSE: To evaluate the prognostic value of positive surgical margins (PSM) focality for the prediction of biochemical recurrence (BCR) in patients undergoing robotic-assisted radical prostatectomy (RARP) for prostate cancer. METHODS: All men with clinically localized prostate cancer undergoing RARP in our tertiary referral centre between May 2005 and August 2016 were retrospectively identified. Patients with neoadjuvant therapy were excluded. Comparisons were made between cases with negative surgical margins (NSM), unifocal PSM (uPSM), and multifocal PSM (mPSM)...
December 5, 2018: World Journal of Urology
Saum Ghodoussipour, Nariman Ahmadi, Natalie Hartman, Giovanni Cacciamani, Gus Miranda, Jie Cai, Anne Schuckman, Hooman Djaladat, Inderbir Gill, Siamak Daneshmand, Mihir Desai
OBJECTIVES: To determine and investigate the intraoperative factors that contribute to a change in plan from continent orthotopic neobladder to ileal conduit or continent cutaneous diversion at the time of radical cystectomy. SUBJECTS AND METHODS: A retrospective review of our prospectively maintained bladder cancer database was performed. Of the 711 patients who underwent radical cystectomy from 2012 to 2016, 387 (54.4%) had given consent to have a NB. Of these 387 patients, 348 (89...
December 5, 2018: World Journal of Urology
Matteo Ferro, Giuseppe Di Lorenzo, Ottavio de Cobelli, Dario Bruzzese, Piero Pignataro, Marco Borghesi, Gennaro Musi, Mihai Dorin Vartolomei, Vincenzo Cosimato, Alessandro Serino, Vincenzo Ieluzzi, Daniela Terracciano, Rocco Damiano, Francesco Cantiello, Francesco Alessandro Mistretta, Matteo Muto, Giuseppe Lucarelli, Pietro De Placido, Carlo Buonerba
BACKGROUND: Cancer-related fatigue (CRF) is a complex condition that is reported in > 50% of cancer patients. In men with castration-resistant prostate cancer (CRPC), CRF was reported in 12-21% of patients. Approved systemic therapy against CRPC is commonly administered in combination with androgen-deprivation treatment (ADT) and, in some cases, with daily, low-dose corticosteroids. Importantly, the use of low-dose corticosteroids is associated with multiple negative effects, including reduced muscle mass...
December 5, 2018: World Journal of Urology
Sebastian Nestler, T Bach, T Herrmann, S Jutzi, F C Roos, C Hampel, J W Thüroff, C Thomas, A Neisius
OBJECTIVE: To compare open simple prostatectomy, endoscopic enucleation and laparoscopic, robot-assisted enucleation of high-volume prostate in terms of operation time, blood loss, transfusion and complication rates and early continence rates. MATERIAL AND METHODS: Patients with BPH treated endoscopically (ThuVEP, Hamburg and Hannover) or robotically (Mainz) were evaluated prospectively for prostate size, free flow and validated questionnaires (IPSS, QoL). 35 patients were matched to patients after open prostatectomy (Mainz) for age, prostate size, IPSS and QoL scores...
December 4, 2018: World Journal of Urology
Ryan P Werntz, Brittany Adamic, Gary D Steinberg
PURPOSE: BCG is the gold standard in management of high-risk non-muscle invasive bladder cancer (HRNMIBC). However, in patients who fail BCG, there are few effective intrasvesical options. This review aims to explore standard and emerging therapies in HRNMIBC. METHODS: A non-systematic literature review was performed using Medline and PubMed. Literature focused on HRNMIBC and BCG failure studies, with particular attention to Phase II and III clinical trials. RESULTS: The only FDA approved therapy for BCG failure patients in Valrubicin...
December 4, 2018: World Journal of Urology
S Abdovic, M Cuk, N Cekada, M Milosevic, A Geljic, S Fusic, M Bastic, Z Bahtijarevic
PURPOSE: To assess the prediction model for late-presenting posterior urethral valve (PUV) in boys with lower urinary tract symptoms (LUTS) using artificial neural network (ANN). MATERIALS AND METHODS: 408 boys aged 3-17 years (median 7.2 years) with LUTS were examined and had bladder diary, ultrasound, uroflowmetry, urine, and urine culture. Cystoscopy was recommended when peak flow rate (Qmax ) was persistently ≤ 5th percentile in patients who were unresponsive to urotherapy and pharmacological treatment (oxybutynin)...
December 4, 2018: World Journal of Urology
Teppei Okamoto, Shingo Hatakeyama, Shintaro Narita, Masahiro Takahashi, Toshihiko Sakurai, Sadafumi Kawamura, Senji Hoshi, Masanori Ishida, Toshiaki Kawaguchi, Shigeto Ishidoya, Jiro Shimoda, Hiromi Sato, Koji Mitsuzuka, Tatsuo Tochigi, Norihiko Tsuchiya, Yoichi Arai, Tomonori Habuchi, Chikara Ohyama
PURPOSE: To investigate the association between the Geriatric Nutritional Risk Index (GNRI) and prognosis of patients with metastatic hormone-naïve prostate cancer (mHNPC) and to design the optimal risk score predicting for prognosis. METHODS: We retrospectively reviewed data from the Michinoku Japan Urological Cancer Study Group database, containing information about 656 patients with mHNPC who initially received androgen-deprivation therapy between 2005 and 2017...
December 4, 2018: World Journal of Urology
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