journal
MENU ▼
Read by QxMD icon Read
search

World Journal of Urology

journal
https://www.readbyqxmd.com/read/28105499/cx4945-suppresses-the-growth-of-castration-resistant-prostate-cancer-cells-by-reducing-ar-v7-expression
#1
Chuangzhong Deng, Jieping Chen, Shengjie Guo, Yanjun Wang, Qianghua Zhou, Zaishang Li, Xingping Yang, Xingsu Yu, Zhenfeng Zhang, Fangjian Zhou, Hui Han, Kai Yao
PURPOSE: The aberrant expression of casein kinase 2 (CK2) has been reported to be involved in the tumorigenesis and progression of prostate cancer. The inhibition of CK2 activity represses androgen-dependent prostate cancer cells by attenuating the androgen receptor (AR) signaling pathway. In this study, we examined the effect of CK2 inhibition in castration-resistant prostate cancer (CRPC) cells, in which AR variants (ARVs) play a predominant role. METHODS: A newly synthetic CK2 selective inhibitor CX4945 was utilized to study the effect of CK2 inhibition in CRPC cells by CCK8 assay and colony formation assay...
January 19, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28093628/perioperative-patient-education-improves-long-term-satisfaction-rates-of-low-risk-prostate-cancer-patients-after-radical-prostatectomy
#2
Alexander Kretschmer, Alexander Buchner, Markus Grabbert, Anne Sommer, Annika Herlemann, Christian G Stief, Ricarda M Bauer
PURPOSE: To evaluate patient-reported functional outcomes after radical prostatectomy (RP) and to analyse the effect of perioperative patient education on satisfaction rates among low-risk prostate cancer patients. METHODS: Inclusion criteria encompassed low-risk prostate cancer patients as defined by the D'Amico criteria, undergoing nerve-sparing RP without pelvic lymph node dissection. Patient-centred functional outcomes, subjective evaluation of perioperative counselling, and patient satisfaction rates were documented...
January 16, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28074261/perioperative-chemotherapy-in-upper-tract-urothelial-carcinoma-a-comprehensive-review
#3
REVIEW
Atiqullah Aziz, Jakub Dobruch, Kees Hendricksen, Luis A Kluth, Andrea Necchi, Aidan Noon, Michael Rink, Florian Roghmann, Roland Seiler, Paolo Gontero, Wassim Kassouf, Shahrokh F Shariat, Evanguelos Xylinas
PURPOSE: To evaluate the role of neoadjuvant (NAC) and adjuvant chemotherapy (AC) in patients with upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU). METHODS: A comprehensive review of the current literature was performed searching for all studies investigating NAC and AC in UTUC in MEDLINE and https://clinicaltrials.gov , prior to April 2016. The following keywords were used: "ureteral neoplasms," "urothelium," "ureter," "upper tract urothelial," "chemotherapy," "adjuvant," "neoadjuvant" and relevant variants...
January 10, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28050642/randomized-double-blind-placebo-controlled-trial-to-compare-solifenacin-versus-trospium-chloride-in-the-relief-of-double-j-stent-related-symptoms
#4
Mohamed H Abdelhamid, Ahmed S Zayed, Waleed E Ghoneima, Akrm A Elmarakbi, Mohamed S El Sheemy, Ahmed Aref, Ahmed Abdelbary, Hani H Nour
PURPOSE: We aimed to compare the safety and efficacy of solifenacin versus trospium chloride and compare each drug versus placebo regarding the relief of stent-related symptoms following uncomplicated ureteroscopic lithotripsy (URSL). METHODS: In a prospective, randomized, double-blind study, 210 eligible patients who underwent URSL with double-J stent insertion were recruited and randomly assigned to either the first group, receiving solifenacin (10 mg), second group, receiving trospium chloride (60 mg), or the third group, receiving placebo (one tablet)...
January 3, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28025660/low-amplitude-rhythmic-contraction-frequency-in-human-detrusor-strips-correlates-with-phasic-intravesical-pressure-waves
#5
Andrew F Colhoun, John E Speich, Lauren F Cooley, Eugene D Bell, R Wayne Barbee, Georgi Guruli, Paul H Ratz, Adam P Klausner
PURPOSE: Low amplitude rhythmic contractions (LARC) occur in detrusor smooth muscle and may play a role in storage disorders such as overactive bladder and detrusor overactivity. The purpose of this study was to determine whether LARC frequencies identified in vitro from strips of human urinary bladder tissue correlate with in vivo LARC frequencies, visualized as phasic intravesical pressure (p ves) waves during urodynamics (UD). METHODS: After IRB approval, fresh strips of human urinary bladder were obtained from patients...
December 26, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/28013345/simulated-physiological-stretch-increases-expression-of-extracellular-matrix-proteins-in-human-bladder-smooth-muscle-cells-via-integrin-%C3%AE-4-%C3%AE-v-fak-erk1-2-signaling-pathway
#6
Shulian Chen, Chuandu Peng, Xin Wei, Deyi Luo, Yifei Lin, Tongxin Yang, Xi Jin, Lina Gong, Hong Li, Kunjie Wang
OBJECTIVES: To investigate the effect of simulated physiological stretch on the expression of extracellular matrix (ECM) proteins and the role of integrin α4/αv, focal adhesion kinase (FAK), extracellular regulated protein kinases 1/2 (ERK1/2) in the stretch-induced ECM protein expression of human bladder smooth muscle cells (HBSMCs). METHODS: HBSMCs were seeded onto silicone membrane and subjected to simulated physiological stretch at the range of 5, 10, and 15% elongation...
December 24, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/28013344/residual-stones-after-percutaneous-nephrolithotomy-comparison-of-intraoperative-assessment-and-postoperative-non-contrast-computerized-tomography
#7
Ahmed M Harraz, Yasser Osman, Ahmed R El-Nahas, Amr A Elsawy, Islam Fakhreldin, Osama Mahmoud, Ahmed El-Assmy, Ahmed A Shokeir
OBJECTIVES: To compare the intraoperative surgeon perspective for detection of residual fragments (RFs) after percutaneous nephrolithotomy (PNL) with postoperative NCCT. METHODS: A prospective study of adult patients who underwent PNL between March and September 2014 was conducted. Stone complexity was evaluated using the Guy's stone score (GSS). All patients were evaluated by pre- and postoperative NCCT. After the procedure, the surgeon had been asked whether there were residual stones or not...
December 24, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/28012043/prospective-evaluation-of-health-related-quality-of-life-after-radical-cystectomy-focus-on-peri-and-postoperative-complications
#8
Alexander Kretschmer, Tobias Grimm, Alexander Buchner, Markus Grabbert, Friedrich Jokisch, Birte-Swantje Schneevoigt, Maria Apfelbeck, Gerald Schulz, Christian G Stief, Alexander Karl
OBJECTIVES: To analyse the impact of perioperative complications and complex treatment courses on postoperative health-related quality of life (HRQOL) after radical cystectomy (RC) and continent (ONB) or incontinent (IC) urinary diversion at multiple prospective time points. METHODS: A total of 121 consecutive patients underwent RC with curative intent between 2013 and 2014. HRQOL was prospectively assessed preoperatively, after 3 and 12 months, using the QLQ-C30 questionnaire...
December 23, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/28004146/residual-tumor-resection-rtr
#9
A Lusch, P Albers
Residual tumor resection in patients with advanced testicular tumor plays a vital role in the multimodal treatment. Treatment indications for residual tumor resection have changed over the last two decades. While patients with advanced seminoma after chemotherapy or radiotherapy rarely need surgery, it is mandatory for most non-seminomatous tumor patients to undergo post-chemotherapy tumor resection. Due to adjunctive surgical procedures, the operation is surgically demanding and should be performed only in specialized high-volume referral centers...
December 21, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/28004145/nobel-prize-nominees-and-the-rise-of-urology-in-europe-around-1900
#10
Nils Hansson, Matthis Krischel, Thorsten Halling, Friedrich Moll, Heiner Fangerau
PURPOSE: Recent historical research has reconstructed the roads leading to the Nobel Prize for the trained urologists Werner Forssmann (1904-1979) in 1956 and Charles Huggins (1901-1997) in 1966. However, the story of urology and the Nobel Prize does not start and end with the laureates. Taking James Israel (1848-1926), Félix Guyon (1831-1920), and Peter J Freyer (1852-1921) as examples, this paper shows that pioneers in urology were in fact runners-up for the award much earlier. METHODS: The study is based on an analysis of original files in the Nobel Prize archive in Stockholm, scientific publications of the early twentieth century, and secondary literature...
December 21, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27999928/erratum-to-focal-salvage-therapy-for-local-prostate-cancer-recurrences-after-primary-radiotherapy-a-comprehensive-review
#11
D A Smit Duijzentkunst, M Peters, J R N van der Voort van Zyp, M A Moerland, M van Vulpen
No abstract text is available yet for this article.
December 20, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27995303/integration-of-mri-to-clinical-nomogram-for-predicting-pathological-stage-before-radical-prostatectomy
#12
Cedric Lebacle, Françoise Roudot-Thoraval, Anissa Moktefi, Mohamed Bouanane, Alexandre De La Taille, Laurent Salomon
BACKGROUND: Debate persists regarding whether MRI should be used routinely for preoperative evaluation of prostate cancer. OBJECTIVE: The aim is to assess the role of prostatic magnetic resonance imaging (MRI) and other preoperative data in extra-prostatic extension (EPE) evaluation. PATIENTS AND METHODS: From 2000 to 2013, 1743 patients operated for radical prostatectomy had a preoperative MRI. Age, clinical stage with digital rectal exam (DRE), PSA, prostate weight, biopsy, MRI and pathological findings of the surgical specimen were noticed...
December 19, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27995302/a-double-blind-placebo-controlled-randomized-clinical-trial-to-evaluate-the-efficacy-of-tranexamic-acid-in-irrigant-solution-on-blood-loss-during-percutaneous-nephrolithotomy-a-pilot-study-from-tertiary-care-center-of-north-india
#13
Ankur Bansal, Aditi Arora
PURPOSE: To evaluate the efficacy and safety of 0.1% tranexamic acid in irrigant fluid in reducing blood loss during PCNL. MATERIALS AND METHODS: The study involved 400 patients who were planned for PCNL and were prospectively randomized into two equal groups. In tranexamic group, 0.1% tranexamic acid was given in irrigant fluid, while in placebo group, distilled water was added to irrigant fluid during surgery. Operative data were recorded which included fall in hemoglobin, total blood loss, operative time, irrigation fluid, length of stay in hospital, requirement of blood transfusion, complications related to PCNL and adverse events of tranexamic acid...
December 19, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27988848/first-clinical-evaluation-of-a-new-single-use-flexible-cystoscope-dedicated-to-double-j-stent-removal-isiris%C3%A2-a-european-prospective-multicenter-study
#14
Steeve Doizi, Guido Kamphuis, Guido Giusti, J L Palmero, J M Patterson, Silvia Proietti, Michael Straub, Jean de la Rosette, Olivier Traxer
PURPOSE: We evaluated a new single-use digital flexible cystoscope with an integrated grasper designed for double-J stent removal, Isiris™, addressing success rate, image quality, deflection, maneuverability and grasper functionality. METHODS: In September 2015, a prospective cohort study was conducted in six tertiary European reference centers. All consecutive patients included underwent double-J stent removal and were 18 years or older. Success rate was defined by complete stent removal...
December 17, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27987032/zero-hospital-admissions-for-infection-after-577-transperineal-prostate-biopsies-using-single-dose-cephazolin-prophylaxis
#15
Lana Pepdjonovic, Guan Hee Tan, Sean Huang, Sarah Mann, Mark Frydenberg, Daniel Moon, Uri Hanegbi, Adam Landau, Ross Snow, Jeremy Grummet
PURPOSE: To determine the rate of hospital admissions for infection after transperineal biopsy of prostate (TPB) with single-dose cephazolin prophylaxis using a prospective database. METHOD: Between April 2013 and February 2016, 577 patients undergoing TPB had 2 g of cephazolin given intravenously at induction of anaesthesia. Data collected from these patients included age, PSA, prostate volume, number of cores taken and post-operative complications. RESULTS: No patients were readmitted to hospital with infection post-TPB...
December 16, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27987031/the-new-grasper-integrated-single-use-flexible-cystoscope-for-double-j-stent-removal-evaluation-of-image-quality-flow-and-flexibility
#16
M Talso, E Emiliani, M Baghdadi, A Orosa, P Servian, A Barreiro, S Proietti, O Traxer
BACKGROUND: A new single use digital flexible cystoscope (FC) Isiris α from Coloplast(®) with an incorporated grasper has been developed to perform double J stent removal. There is a lack of data regarding the comparison of image quality, flexibility and flow between classic cystoscopes and the new Isiris α. MATERIALS AND METHODS: Five different FC were used to compare the image quality, the field of view, the loss of flow and the deflection loss. Two standardized grids, three stones of different composition and a ruler's image were filmed in four standardized different scenarios...
December 16, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27987030/improved-decision-making-in-intermediate-risk-prostate-cancer-a-multicenter-study-on-pathologic-and-oncologic-outcomes-after-radical-prostatectomy
#17
Jean Baptiste Beauval, Guillaume Ploussard, Bastien Cabarrou, Mathieu Roumiguié, Adil Ouzzane, Jérome Gas, Annabelle Goujon, Gautier Marcq, Romain Mathieu, Sébastien Vincendeau, Xavier Cathelineau, Pierre Mongiat-Artus, Laurent Salomon, Michel Soulié, Arnaud Méjean, Alexandre de La Taille, Morgan Rouprêt, François Rozet
BACKGROUND: Prognoses for intermediate-risk prostate cancer (PCa) remain heterogeneous. Improved substratification could optimize treatment and monitoring strategies. The objective was to validate this subclassification in a radical prostatectomy (RP) series. METHODS: Between 2000 and 2011, 4038 patients who underwent RP for intermediate-risk PCa in seven French academic centers were included. Unfavorable intermediate-risk (UIR) PCa was defined as having a primary Gleason score of 4, ≥50% positive biopsy cores (PPBC), or more than one D'Amico intermediate-risk factor (i...
December 16, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27933389/high-volume-is-the-key-for-improving-in-hospital-outcomes-after-radical-prostatectomy-a-total-population-analysis-in-germany-from-2006-to-2013
#18
Christer Groeben, Rainer Koch, Martin Baunacke, Manfred P Wirth, Johannes Huber
PURPOSE: Outcomes of radical prostatectomy are prone to publication bias, because most of the data originated from highly specialized centers. We assessed in-hospital outcomes of all radical prostatectomies in Germany from 2006 to 2013 focusing on caseload volume, surgical approach, and certification status. METHODS: We analyzed the nationwide German hospital billing data covering 221,331 radical prostatectomies from 2006 to 2013. Outcomes were in-hospital mortality, surgical revision, and transfusion rates and the length of stay...
December 8, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27928592/radiation-induced-complex-anterior-urinary-fistulation-for-prostate-cancer-a-retrospective-multicenter-study-from-the-trauma-and-urologic-reconstruction-network-of-surgeons-turns
#19
E Charles Osterberg, Alex J Vanni, Thomas W Gaither, Mohannad A Awad, Joshua A Broghammer, Scott C Pate, Hadley Wyre, Jeremy B Myers, Sean P Elliott, Suprita Krishna, Lee C Zhao, Christopher McClung, Bradley A Erickson, Benjamin N Breyer
PURPOSE: To characterize anterior urinary fistulae following radiotherapy for prostate cancer. METHODS: Over 10 years, 31 men were identified to have an anterior urinary fistula. A retrospective database was created to evaluate patient demographics, presentation, diagnostic procedures, operative interventions, outcomes, and complications. Comparisons between men who underwent cystectomy versus bladder-sparing surgeries were performed. RESULTS: At a median age of 73 (interquartile range (IQR) 68...
December 7, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27900453/incidence-grade-and-distribution-of-prostate-cancer-following-transperineal-template-guided-mapping-biopsy-in-patients-with-atypical-small-acinar-proliferation
#20
Gregory S Merrick, Robert W Galbreath, Abbey Bennett, Wayne M Butler, Edward Amamovich
PURPOSE: To evaluate the role of transperineal template-guided mapping biopsy (TTMB) in patients with atypical small acinar proliferation (ASAP) diagnosed via transrectal ultrasound-guided needle biopsy (TRUS). METHODS: In total, 132 consecutive patients with TRUS-diagnosed ASAP underwent TTMB by means of an anatomic-based technique with sampling of 24 biopsy regions. For each of the 24 regions, 1-3 biopsy cores were obtained (depending on prostate size). No patient underwent pre-biopsy MRI imaging...
November 29, 2016: World Journal of Urology
journal
journal
28632
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"