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Carbohydrate Polymers

Weiqin Wang, Mengying Li, Zhenhai Zhang, Changchang Cui, Jianping Zhou, Lifang Yin, Huixia Lv
A novel tLyP-1-HA-PTX conjugate is designed for combining the solubilization capacity of Paclitaxel (PTX) and tumor tissue targeting - penetration effect of hyaluronic acid (HA) as well as cell penetration peptide (tLyP-1). In addition, through modifying by tLyP-1, the anticancer scope of tLyP-1-HA-PTX conjugate was expanded from tumor cells expressing CD44 receptors to those of expressing NRP1 receptors. In vitro antitumor ability of tLyP-1-HA-PTX conjugate and cellular uptake tests were conducted to testify the tumor-targeting behavior of the conjugates...
January 20, 2017: Carbohydrate Polymers
Xiao-Hong Yu, Ying Liu, Xian-Ling Wu, Li-Zhai Liu, Wei Fu, Dan-Dan Song
In this study, crude American ginseng polysaccharide (AGPS) was extracted with hot water and preliminarily purified by using resin S-8 and Polyamide columns. Then, it was further purified and separated by DEAE-Sepharose CL-6B and Sepharose CL-6B chromatography, respectively. Five main fractions were obtained, named WPS-1, WPS-2, SPS-1, SPS-2 and SPS-3. Their homogeneities and structural characteristics were elucidated based on UV-vis spectroscopy, High Performance Gel Filtration Chromatography (HPGFC), Gas Chromatography (GC), Scanning Electron Microscopy (SEM), Infrared Spectrum (IR), and NMR Spectroscopy methods...
January 20, 2017: Carbohydrate Polymers
Daniela Šmejkalová, Tomáš Muthný, Kristina Nešporová, Martina Hermannová, Eva Achbergerová, Gloria Huerta-Angeles, Marek Svoboda, Martin Čepa, Veronika Machalová, Dominika Luptáková, Vladimír Velebný
Nanosized materials offer promising strategy for topical drug delivery due to their enhancing effect on drug percutaneous transport across the stratum corneum barrier. In this work, polymeric micelles made from hydrophobized hyaluronic acid (HA) were probed for skin delivery. Compared to non-polymeric micelle solutions containing similar drug amount, in vitro skin penetration analysis indicated 3 times larger deposition of drug in the epidermis and 6 times larger drug deposition in the dermis after 5h of topical treatment in Franz diffusion cells...
January 20, 2017: Carbohydrate Polymers
Ivan Šimkovic, Ivan Kelnar, Raniero Mendichi, Tomáš Bertok, Jaroslav Filip
In our study we used holocelluloses from sugar beet and bagasse for film preparation. Films from sugar beet holocellulose have better mechanical properties than from bagasse holocellulose. By subsequent carboxymethylation of bagasse holocellulose, films with better properties were produced. Specimens prepared from combined sugar beet and bagasse carboxymethylated holocellulose had the best mechanical properties. The results could be explained by the ratios of cellulose, arabinan, polygalacturonan and xylan content in individual films, based on the elemental analysis data...
January 20, 2017: Carbohydrate Polymers
Yuanyuan Pu, Qingsong Zou, Dianzhi Hou, Yiping Zhang, Shan Chen
Ultrasonic degradation of six dextran samples with different initial molecular weights (IMW) has been performed to investigate the degradation behavior and chain scission mechanism of dextrans. The weight-average molecular weight (Mw) and polydispersity index (D value) were monitored by High Performance Gel Permeation Chromatography (HPGPC). Results showed that Mw and D value decreased with increasing ultrasonic time, resulting in a more homologous dextran solution with lower molecular weight. A significant degradation occurred in dextrans with higher IMW, particularly at the initial stage of the ultrasonic treatment...
January 20, 2017: Carbohydrate Polymers
Ons Chaabouni, Sami Boufi
Cellulose nanofibrils (CNFs) are nanoscale cellulose produced from renewable resources with strong reinforcing potential when included in a polymer matrix. In this work, the effect of the addition of CNFs on the properties of waterborne polyvinylacetate (PVA) adhesive was investigated. Adhesive formulations with different contents in CNFs from 1 to 10wt.% was prepared by simple mixing of PVA dispersion with CNFs suspension in water. The viscosity of the adhesive increased with the addition of CNFs, namely over a content of 5%...
January 20, 2017: Carbohydrate Polymers
Anny Yanuriati, Djagal Wiseso Marseno, Rochmadi, Eni Harmayani
Porang is a potential source of glucomannan. This research objective was to find a direct glucomannan isolation method from fresh porang corm to produce high purity glucomannan. Two isolation methods were performed. In first method, sample was water dissolved using Al2(SO4)3 as flocculant for 15 (AA15) or 30 (AA30) minutes with purification. In second method, sample was repeatedly milled using ethanol as solvent and filtered for 5 (EtOH5) or 7 (EtOH7) times without purification. The characteristics of obtained glucomannan were compared to those of commercial porang flour (CPF) and purified konjac glucomannan (PKG)...
January 20, 2017: Carbohydrate Polymers
Balbir Singh Kaith, Rajeev Jindal, Asim Kumar Jana, Mithu Maiti
No abstract text is available yet for this article.
January 20, 2017: Carbohydrate Polymers
Yiming Feng, Georg Kopplin, Kimihiko Sato, Kurt I Draget, Kjell M Vårum
Alginates are polysaccharides that are widely used in relation to their ability to form gels. Recently we reported that alginates may also form gels with chitosan oligomers as crosslinkers (Khong, Aarstad, Skjåk-Bræk, Draget, & Vårum, 2013). The purpose of the present study was to characterize alginate gels crosslinked with calcium and chitosan oligomers. Using two different alginates of similar molecular weights but different chemical composition, i.e. guluronic acid content of 46 and 68%, we found that both alginates could form homogeneous gels with calcium and chitosan oligomers separately and without syneresis...
January 20, 2017: Carbohydrate Polymers
Jing Wang, Jiang-Bo Xi, Wei Chen, Shao-Hua Huang, Zheng-Wu Bai
Enantioseparation plays an important role for many fields and for pharmaceutical industry in particular. Chiral stationary phase (CSP) is the core of chiral liquid chromatography that effectively implements enantioseparation. In order to develop coated type CSPs with excellent enantioseparation capability and high tolerance against mobile phases, in this work, a series of chitosan bis(3,5-dimethylphenylcarbamate)-(alkyl urea)s were synthesized, which were coated on 3-aminopropyl silica gel to afford new CSPs...
January 20, 2017: Carbohydrate Polymers
Anna Alekseeva, Giulia Mazzini, Giuseppe Giannini, Annamaria Naggi
Owing to their anti-tumor and anti-inflammatory properties, non-anticoagulant glycol-split (gs) heparins, obtained by periodate oxidation/borohydride reduction, are of growing interest. The present study was focused on the structural characterization of N-acetylated gs-heparin Roneparstat, a promising anti-cancer heparanase-inhibiting drug currently being investigated in clinical trials. The major and minor structural features of structurally complex Roneparstat have been characterized for the first time using conductimetric titration, size-exclusion chromatography with triple detector array, NMR and LC/MS...
January 20, 2017: Carbohydrate Polymers
Zhong Lu, Jingting Gao, Qingfeng He, Jie Wu, Donghui Liang, Hao Yang, Rong Chen
Nano Ag/ZnO hybrid material has been considered to be a promising nanocomposites for biomedical application because it has enhanced antibacterial activity and low cytotoxicity. Here a sponge-like nano Ag/ZnO-loaded chitosan composite dressing was first synthesized via preparing a chitosan sponge by lyophilization process, followed by the incorporation of Ag/ZnO nanocomposites into chitosan sponge. The porosity, swelling, blood clotting and in vitro antibacterial activity against drug-sensitive and drug-resistant pathogenic bacteria were evaluated...
January 20, 2017: Carbohydrate Polymers
F A Corsello, P A Bolla, P S Anbinder, M A Serradell, J I Amalvy, P J Peruzzo
Chitosan/cellulose nanocrystals (CH-CN) films were obtained by casting of dispersions, and treated with NaOH for neutralization proposes. The composition of films was varied from 1 to 10wt.% of CN. Changes in the morphology of the systems were correlated with the different properties studied. FTIR revealed the presence of a weak interaction between the polymer matrix and nanofiller, confirmed by a slightly increase in thermal stability. SEM images suggested that incorporating CN amounts higher than 3wt.% generates phase-segregated systems, and SAXS showed that CH avoid the typical organization of CN at concentrations below 5wt...
January 20, 2017: Carbohydrate Polymers
Akashdeep Singh, Bhumika Mangla, Sheshank Sethi, Sunil Kamboj, Radhika Sharma, Vikas Rana
The aim of present investigation was to utilize quality by design approach for the synthesis of polyacrylamide corn fibre gum (PAAm-g-CFG) from corn fibre gum (CFG) by varying concentration of acrylamide and initiator. The spectral analysis (ATR-FTIR, (1)H NMR, DSC, X-ray and Mass spectroscopy) was conducted to assure grafting copolymerization of CFG with acrylamide. The powder flow properties confirm the porous nature of PAAm-g-CFG. The grafted copolymer dispersion showed shear thinning behaviour that follows Herschel Bulkley model...
January 20, 2017: Carbohydrate Polymers
Joanna Mierczyńska, Justyna Cybulska, Artur Zdunek
Yield, properties and functionality of pectins depend on the source material and method of extraction. The objective of this work was to compare pectinolytic enzyme activity in fresh pulp as well as the physicochemical and rheological properties of polysaccharides extracted with citric acid from six new potential sources: fruit materials - peach, blackcurrant, raspberry, strawberry, plum and a vegetable Source: carrot. The uronic acid content of polysaccharides extracted in citric acid depended on pectinolytic enzymes activity in fresh plant tissues and ranged between 16...
January 20, 2017: Carbohydrate Polymers
Ning Zhang, Jiachao Xu, Xin Gao, Xiaoting Fu, Di Zheng
Enhanced film water resistance of paper cups was achieved by physically blending sodium alginate (NaAlg) and gellan gum with crosslinking treatment. Pure and blended films were prepared and characterized via Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), and positron annihilation lifetime spectroscopy (PALS). Results demonstrated excellent compatibility between the two polysaccharides. Total mixed solution concentration, component ratio, glycerol content, Ca(2+) concentration, crosslinking time, and dry temperature affected water resistance...
January 20, 2017: Carbohydrate Polymers
Caichao Wan, Yue Jiao, Tiangang Qiang, Jian Li
We describe a rapid and facile chemical precipitation method to grow goethite (α-FeOOH) nanoneedles and nanoflowers on the carbon aerogels which was obtained from the pyrolysis of cellulose aerogels. When evaluated as electromagnetic interference (EMI) shielding materials, the α-FeOOH/cellulose-derived carbon aerogels composite displays the highest SEtotal value of 34.0dB at the Fe(3+)/Fe(2+) concentration of 0.01M, which is about 4.8 times higher than that of the individual α-FeOOH (5.9dB). When the higher or lower Fe(3+)/Fe(2+) concentrations were used, the EMI shielding performance deterioration occurred...
January 20, 2017: Carbohydrate Polymers
Ana P F Monteiro, Cíntia M S L Rocha, Michele F Oliveira, Sávio M L Gontijo, Ricardo R Agudelo, Rubén D Sinisterra, Maria E Cortés
This study aimed to compare two nanofiber drug delivery systems that were prepared with an electrospun process and have the potential to serve as adjuvants for the treatment of periodontal disease. The first system was composed of polycaprolactone loaded with tetracycline (TCN) and the second was composed of polycaprolactone loaded with tetracycline/β-cyclodextrin (TCN:BCD). An antimicrobial diffusion test was performed for each of these sets of nanofibers with the microorganisms, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, both of which contribute to periodontal disease...
January 20, 2017: Carbohydrate Polymers
Junidah Lamaming, Rokiah Hashim, Cheu Peng Leh, Othman Sulaiman
Cellulose nanocrystals were isolated from oil palm trunk by total chlorine free method. The samples were either water pre-hydrolyzed or non-water pre-hydrolyzed, subjected to soda pulping, acidified and ozone bleached. Cellulose and cellulose nanocrystal (CNC) physical, chemical, thermal properties, and crystallinity index were investigated by composition analysis, scanning electron microscopy, transmission electron microscopy, fourier transform infrared, thermogravimetric analysis and X-ray diffraction. Water pre-hydrolysis reduced lignin (<0...
January 20, 2017: Carbohydrate Polymers
Young-Seok Jung, Wooram Park, Hyejin Park, Deok-Keun Lee, Kun Na
The aim of this research is the development of a new type of intra-articularly injectable thermo-sensitive hydrogels for the long-term delivery of Piroxicam (PX). The thermo-sensitive hydrogel was prepared by the simple physical mixing of HA and Pluronic F-127 (HP) in aqueous solution. The addition of high-molecular-weight HA not only enhanced the mechanical strength of the hydrogel but also elicited a sustained drug release. This result could be attributed to the high-molecular-weight HA-assisted inter-micellar packing in the hydrogel inner structure...
January 20, 2017: Carbohydrate Polymers
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