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Cancer Investigation

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https://www.readbyqxmd.com/read/28165839/targeting-vegfr-2-in-metastatic-gastric-cancer-results-from-a-literature-based-meta-analysis
#1
Giandomenico Roviello, Karol Polom, Franco Roviello, Daniele Marrelli, Andrea Giovanni Multari, Giovanni Paganini, Chiara Pacifico, Daniele Generali
Angiogenesis is a key process in cancer development. We performed a meta-analysis to assess the efficacy and safety of the novel VEGFR-2 inhibitors in patients with metastatic gastric and gastroesophageal junction cancer. A literature-based meta-analysis of randomized controlled trials (RCTs) was undertaken. The primary outcome was the overall survival. The pooled analysis from RCTs on anti-VEGFR-2 inhibitors revealed a significant increase in overall survival (hazard ratio for death: 0.69, 95% confidence interval: 0...
February 6, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28165774/factors-and-costs-associated-with-delay-in-treatment-initiation-and-prolonged-length-of-stay-with-inpatient-epoch-chemotherapy-in-patients-with-hematologic-malignancies
#2
Melissa K Accordino, Jason D Wright, Sowmya Vasan, Alfred I Neugut, Grace C Hillyer, Dawn L Hershman
Reducing delays related to inpatient chemotherapy may reduce healthcare costs. Using a national database, we identified patients with lymphoma/leukemia with ≥1 etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone (EPOCH) chemotherapy claim and evaluated chemotherapy initiation delay (ID), >1 day from admission. Standard tests/procedures prior to initiation were evaluated. Among 4453 inpatient cycles, 19.7% had ID, odds ratio 2.28 (95% confidence interval: 1.83-2.85) with cycle 1 compared to cycle 2, and mean costs were higher in patients with ID than without ID (p < ...
February 6, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28112977/early-prognostic-value-of-monitoring-serum-free-light-chain-in-patients-with-multiple-myeloma-undergoing-autologous-stem-cell-transplantation
#3
Zübeyde Nur Özkurt, Gülsan Türköz Sucak, Şahika Zeynep Akı, Münci Yağcı, Rauf Haznedar
We hypothesized the levels of free light chains obtained before and after autologous stem cell transplantation can be useful in predicting transplantation outcome. We analyzed 70 multiple myeloma patients. Abnormal free light chain ratios before stem cell transplantation were found to be associated early progression, although without any impact on overall survival. At day +30, the normalization of levels of involved free light chain related with early progression. According to these results almost one-third reduction of free light chain levels can predict favorable prognosis after autologous stem cell transplantation...
January 23, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28135863/evaluation-of-tc-99m-3prgd2-integrin-receptor-imaging-in-the-differential-diagnosis-of-breast-lesions-and-comparison-with-mammography
#4
COMPARATIVE STUDY
Guibing Chen, Zhong Ouyang, Fan Wang, Hua Wu, Bing Jia, Mahendra D Chordia
PURPOSE: The aims of this study were to evaluate and compare efficacies of Tc-99m-3PRGD2 integrin receptor imaging under variety of conditions for the diagnosis of breast lesions, in addition to comparison with mammography. MATERIALS AND METHODS: Seventy-two female patients with established breast lesions were recruited. All patients were examined by Tc-99m-3PRGD2 integrin receptor imaging and mammography. Whole-body scan and SPECT/CT were acquired at dual time points of 2 and 4 h after injection using standard protocol...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28135860/altered-expression-of-sphingosine-1-phosphate-metabolizing-enzymes-in-oral-cancer-correlate-with-clinicopathological-attributes
#5
Supriya Vishwakarma, Rahul Agarwal, Sudhir K Goel, Rajendra K Panday, Renu Singh, Ravi Sukumaran, Sarita Khare, Ashok Kumar
We have determined the gene expression of sphingosine-1-phosphate (S1P) metabolizing enzymes (SphK1, SphK2, SGPL1, SGPP1, SGPP2, PPAP2A, PPAP2B, and PPAP2C) by quantitative real-time polymerase chain reaction in tumor tissues and adjacent normal tissues of 50 oral squamous cell carcinoma (OSCC) patients. Expression of SphK1 and SGPP1 genes was up-regulated significantly in 70% and 75% OSCC tumors respectively. Importantly, expression of SphK2 and PPAP2B was down-regulated in the tumor tissues of 70% OSCC patients...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28135856/promoter-hypermethylation-and-its-impact-on-expression-of-mgmt-gene-in-the-git-malignant-patients-of-kashmiri-origin
#6
Arif Akbar Bhat, Hilal Ahmad Wani, Shiekh Ishaq, Ajaz Ahmad Waza, Rawoof Ahmad Malik, Iram Shabir, Showkat Jeelani, Showkat Kadla, Waseem Qureshie, Akbar Masood, Sabhiya Majid
Epigenetic alterations, in addition to multiple gene abnormalities, are involved in the genesis and progression of human cancers. Gastrointestinal tract (GIT) cancer is a major medical and economic burden worldwide. Aberrant methylation of CpG islands within promoter regions is associated with transcriptional inactivation of various tumor suppressor genes. Although a number of cancer-associated genes have been found to be hypermethylated in GIT cancer, valuable methylation markers for early diagnosis and prognostic evaluation of this cancer remain largely unknown...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28118074/gper-promoter-methylation-controls-gper-expression-in-breast-cancer-patients
#7
Christine Weissenborn, Tanja Ignatov, Norbert Nass, Thomas Kalinski, Serban Dan Costa, Ana Claudia Zenclussen, Atanas Ignatov
Recently, we found that G-protein-coupled estrogen receptor (GPER) protein expression decreased during breast carcinogenesis, and that GPER promoter is methylated. Here we analyzed GPER promoter methylation in 260 primary breast cancer specimens by methylation-specific polymerized chain reaction. The results demonstrated that GPER protein down-regulation significantly correlated with GPER promoter hypermethylation (p < .001). Comparison of 108 tumors and matched normal breast tissues indicated a significant GPER down-regulation in cancer tissues correlating with GPER promoter hypermethylation (p < ...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28107084/can-diffusion-weighted-imaging-and-related-apparent-diffusion-coefficient-be-a-prognostic-value-in-women-with-breast-cancer
#8
Paola Rabasco, Rocchina Caivano, Vittorio Simeon, Giuseppina Dinardo, Antonella Lotumolo, Matilde Gioioso, Antonio Villonio, Giancarlo Iannelli, Felice D'Antuono, Alexis Zandolino, Luca Macarini, Giuseppe Guglielmi, Aldo Cammarota
PURPOSE: To analyze diffusion-weighted imaging (DWI) and the related apparent diffusion coefficient (ADC) in women with breast cancer, correlating these values with the presence at 3 years of distant metastases, and to demonstrate that DWI-Magnetic Resonance Imaging (MRI) and related ADC values may represent a prognostic value in the study of women with breast cancer. MATERIALS AND METHODS: Sixty women (aged 45-73 years) affected with breast cancer with a follow-up in 3 years were enrolled...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28103112/potassium-iodate-differently-regulates-the-proliferation-migration-and-invasion-of-human-thyroid-cancer-cells-via-modulating-mir-146a
#9
Yan Liu, Hong Li, Jiayue Zhang, Xu Gao
The effects of different doses of potassium iodate (KIO3) on the malignancy of thyroid cancer were investigated. Results showed that the proliferation, migration, and invasion of SW579 thyroid cancer cells were improved by 10(-6) M KIO3, which was associated with microRNA(miR)-146a deficit; 10(-2) M KIO3 significantly enhanced miR-146a level and suppressed SW579 cell proliferation, migration, and invasion. The diverse effects of KIO3 on SW579 cells were associated with the expression changes in miR-146a targets, Bcl-2, Bax, and caspase-3...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28102711/higher-expression-of-ercc1-may-be-associated-with-resistance-to-adjuvant-platinum-based-chemotherapy-in-gastric-cancer
#10
Jiayi Wan, Lin Chao, Arier C Lee, Qi Chen
Potential predictive biomarker(s) to respond to chemotherapy in gastric cancer are unclear. Excision repair cross-complementing 1 (ERCC1), a DNA repair enzyme, is associated with clinical outcomes in gastric cancer. Here, we investigated the expression of ERCC1 in gastric cancer with platinum-based chemotherapy after surgery, and the association between ERCC1 expression and clinical parameters was analyzed. Our data showed that high levels of ERCC1 expression were positively associated with resistance to platinum-based chemotherapy but not with lymph node metastasis and pathological stage...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28102708/corrigendum
#11
(no author information available yet)
No abstract text is available yet for this article.
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28095066/association-of-osteopontin-gene-polymorphisms-with-colorectal-cancer
#12
Asmaa Kamal, Rania Kamal Darwish, Samar Saad, Mohamed Salama, Tarek S El-Baradie, Heba G M Mahmoud, Yasmine Elshiwy
We investigated the association of the Osteopontin (OPN) (rs9138 and rs1126616) polymorphisms with colorectal cancer (CRC). One hundred CRC patients and 112 healthy individuals were subjected to OPN (rs9138 and rs1126616) genotyping and measurement of OPN protein plasma level. The C allele of OPN rs1126616 and the CC haplotype were significantly higher in CRC patient (p = 0.036, 0.003, respectively). In females, the C allele of OPN rs9318 (A/C) polymorphism was significantly associated with increased CRC risk (p = 0...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28095062/microrna-196a-as-a-potential-diagnostic-biomarker-for-esophageal-squamous-cell-carcinoma
#13
Mona Fendereski, Mohammad Farid Zia, Mohammad Shafiee, Forousan Safari, Mohammad Hosien Saneie, Manoochehr Tavassoli
We observed significant up-regulation of miR-196a in esophageal squamous cell carcinoma (ESCC) as compared with their adjacent normal tissue (p = .002). Receiver operating characteristics curve analysis confirmed the suitability of miR-196a as a potential tumor marker for diagnosis of ESCC. Furthermore, analysis of miR-196a levels in saliva samples determined an average of 27-fold up-regulations in ESCC patients compared with healthy group. Our results suggest that salivary miR-196a may be a suitable noninvasive biomarker for diagnosis of ESCC...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28055278/corrigendum
#14
(no author information available yet)
No abstract text is available yet for this article.
January 2, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28029807/physicians-perspectives-and-practice-patterns-toward-opportunistic-salpingectomy-in-high-and-low-risk-women
#15
Nathaniel L Jones, Jay Schulkin, Renata R Urban, Jason D Wright, William M Burke, June Y Hou, Cora A McElwain, Ana I Tergas
BACKGROUND: Opportunistic bilateral salpingectomy (OBS) has been proposed as an ovarian cancer risk-reducing strategy. METHODS: A survey was emailed to 300 members of the American College of Obstetricians and Gynecologists. RESULTS: 125 (42%) surveys were returned: 60% female, 88% generalists, 67% private practice. Only 36% correctly identified the lifetime risk of ovarian cancer, only 23% understood the risk-reducing benefit of bilateral salpingo-oophorectomy...
January 2, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/27996308/anticancer-activity-of-curcumin-and-its-analogues-preclinical-and-clinical-studies
#16
REVIEW
Alessandro Allegra, Vanessa Innao, Sabina Russo, Demetrio Gerace, Andrea Alonci, Caterina Musolino
Curcumin has been shown to have a wide variety of therapeutic effects, ranging from anti-inflammatory, chemopreventive, anti-proliferative, and anti-metastatic. This review provides an overview of the recent research conducted to overcome the problems with the bioavailability of curcumin, and of the preclinical and clinical studies that have reported success in combinatorial strategies coupling curcumin with other treatments. Research on the signaling pathways that curcumin treatment targets shows that it potently acts on major intracellular components involved in key processes such as genomic modulations, cell invasion and cell death pathways...
January 2, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/27911119/phase-ii-study-of-dasatinib-in-previously-treated-patients-with-advanced-non-small-cell-lung-cancer
#17
Michael J Kelley, Gautam Jha, Debra Shoemaker, James E Herndon, Lin Gu, William T Barry, Jeffrey Crawford, Neal Ready
The Src pathway in activated in about one-third of non-small cell lung cancer (NSCLC) tumors. Dasatinib has Src-inhibitor activity. We examined the activity of dasatinib in 37 patients with advanced, previously treated NSCLC. Among the 29 patients who underwent pre-treatment biopsy for RNA biomarker analysis, 25 were treated with dasatinib 70 mg twice daily. There were no responses. Five patients discontinued treatment due to toxicity. Three patients had minor biopsy-related pneumothoraces. Given the lack of responses, no biomarkers were analyzed...
January 2, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/27901596/magnetic-resonance-imaging-in-the-pre-surgical-staging-of-breast-cancer-our-experience
#18
Paola Rabasco, Rocchina Caivano, Giuseppina Dinardo, Matilde Gioioso, Antonella Lotumolo, Giancarlo Iannelli, Antonio Villonio, Giuseppe La Torre, Stefano D'Errico, Luca Macarini, Giuseppe Guglielmi, Aldo Cammarota
PURPOSE: To investigate the clinical impact of magnetic resonance imaging (MRI) in the detection of multifocal-multicentric breast cancers, already identified by mammography and ultrasound, and analyzed histologically, to evaluate its role in preoperative staging. MATERIALS AND METHODS: From January 2012 to February 2014, 188 patients, aged 28 to 74 years, newly diagnosed with breast cancer on conventional imaging (mammography and ultrasound) were enrolled. They underwent preoperative contrast-enhanced 3T MRI...
January 2, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/27901576/the-high-frequency-of-pik3ca-mutations-in-iranian-breast-cancer-patients
#19
Ghasem Azizi Tabesh, Pantea Izadi, Forouzandeh Fereidooni, Amir Nader Emami Razavi, Javad Tavakkoly Bazzaz
In breast cancer, somatic mutations of PIK3CA oncogene are common. We investigated the mutational status of exons 9 and 20 of the PIK3CA gene by polymerase chain reaction and direct sequencing in 80 breast tumors, and observed that 45% of these contained PIK3CA mutations in the mentioned exons. These mutations were found more in progesterone receptor positive and Her2- tumors, but this association did not reach a statistically significant level. Also, we observed a significant association between PIK3CA mutations and low-grade tumors...
January 2, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/27892728/a-phase-i-ii-study-of-nab-paclitaxel-cisplatin-and-cetuximab-with-concurrent-radiation-therapy-for-locally-advanced-squamous-cell-cancer-of-the-head-and-neck
#20
Stephen G Chun, Randall Hughes, Baran D Sumer, Larry L Myers, John M Truelson, Saad A Khan, Tsung-Wei Ma, Yang Xie, John S Yordy, Susan Cooley, Jean Wu, Hak Choy, Lucien A Nedzi
Nab-paclitaxel might impact efficacy of radiation for head and neck (H&N) cancer. Nab-paclitaxel, cisplatin, cetuximab, and radiation were evaluated in patients with locally advanced head and neck cancer in this phase I/II trial. Median follow-up was 24 months for 34 patients. The maximum tolerated dose of nab-paclitaxel was 20 mg/m(2) with 20 mg/m(2) cisplatin and 250 mg/m(2) cetuximab. The 2-year progression-free survival (PFS) was 60% (95% confidence interval (CI) 0.42, 0.78), local control 71% (95% CI 0...
January 2, 2017: Cancer Investigation
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