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Cancer Investigation

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https://www.readbyqxmd.com/read/28333566/is-change-in-hemoglobin-level-a-predictive-biomarker-of-tyrosine-kinase-efficacy-in-metastatic-renal-cell-carcinoma-a-turkish-oncology-group-study
#1
Cemil Bilir, İbrahim Yıldız, Ahmet Bilici, Mahmut Ucar, Veli Berk, Yaşar Yıldız, Ozan Yazıcı, Gökşen İnanç İmamoğlu, Nuri Karadurmuş, Kezban Nur Pilancı, Erkan Arpacı, Özgür Tanrıverdi, Ebru Karcı, Süleyman Temiz, Erdinc Nayır, Esin Oktay, Pınar Dal, İbrahim Petekkaya, Ceyhun Varım, Hakan Cinemre
BACKGROUND: There are insufficient predictive markers for renal cell carcinoma (RCC). METHODS: A total of 308 metastatic RCC patients were analyzed retrospectively. RESULTS: The increased hemoglobin (Hb) group had significantly higher progression-free survival and overall survival (OS) compared with the decreased Hb group at 11.5 versus 6.35 months (p < .001) and 21.0 versus 11.36 months (p < .001) respectively. The 1- and 3-year OS rates were higher in the Hb increased group, i...
March 23, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28333553/cyclooxygenase-2-induction-by-amino-acid-deprivation-requires-p38-mitogen-activated-protein-kinase-in-human-glioma-cells
#2
Zhiwen Li, Chi-Ming Chang, Lanfang Wang, Ping Zhang, Hui-Kuo G Shu
Glioblastomas (GBMs) are malignant brain tumors that can outstrip nutrient supplies due to rapid growth. Cyclooxygenase-2 (COX-2) has been linked to GBMs and may contribute to their aggressive phenotypes. Amino acid starvation results in COX-2 mRNA and protein induction in multiple human glioma cell lines in a process requiring p38 mitogen-activated protein kinase (p38-MAPK) and the Sp1 transcription factor. Increased vascular endothelial growth factor expression results from starvation-dependent COX-2 induction...
March 23, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28301214/novel-glycopyrrolidine-compounds-inhibit-human-cancer-cell-proliferation-and-induce-apoptotic-mode-of-cell-death
#3
Hemadev Bhoopalan, Shilpa Tentu, Prasana R, Purushothaman S, Akkanapally Venu, Ragavachary Raghunathan, Suresh Babu Pakala, Suresh Kumar Rayala, Ganesh Venkatraman
Spirocyclic compounds, present in a number of bioactive natural alkaloids, are cyclic systems containing one carbon atom common to two rings. A highly regioselective glycopyrrolidine compound library was synthesized using 1,3-dipolar cycloaddition method, and its efficacy was tested on cell lines representing most commonly occurring cancers and the molecular mechanism of cell death deciphered. Results showed that among the 16 compounds screened, RPRR210 showed the most potent anticancer activity and induced cell cycle arrest, inhibited migration, caused cell death by inducing apoptosis through the intrinsic pathway, and were nontoxic to normal cells...
March 16, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28272917/candidate-gene-analysis-of-breast-cancer-in-the-jordanian-population-of-arab-descent-a-case-control-study
#4
Laith N Al-Eitan, Reem I Jamous, Rame H Khasawneh
This study aimed to investigate whether there are specific polymorphisms within six genes (BRCA1, BRCA2, TP53, DAPK1, MMP9 promoter, and TOX3) that are associated with breast cancer among the Jordanian population. Sequenom MassARRAY system was used to genotype 17 single nucleotide polymorphisms (SNPs) within these genes in 230 Jordanian breast cancer patients and 225 healthy individuals. Three SNPs (MMP9 (rs6065912), TOX3 (rs1420546), and DAPK1 (rs11141901) were found to be significantly associated with an increased risk of breast cancer (p < ...
March 8, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28272913/phase-i-study-of-sorafenib-in-combination-with-intermittent-hepatic-arterial-infusion-chemotherapy-for-unresectable-hepatocellular-carcinoma
#5
Morihiko Ishizaki, Masaki Kaibori, Kosuke Matsui, Hiroki Ikeda, Katsunori Yoshida, Kazuichi Okazaki, Syuji Kariya, Noboru Tanigawa, Richi Nakatake, Hideyuki Matsushima, Tatsuma Sakaguchi, Masanori Kon
OBJECTIVES: We conducted a phase I study of sorafenib and intermittent hepatic arterial infusion chemotherapy using cisplatin for unresectable hepatocellular carcinoma. METHODS: Sorafenib was administered continuously, whereas cisplatin was administered once every 3 weeks. We estimated the safety and efficacy. RESULTS: Fifteen patients were enrolled into this study. The dose-limiting toxicities occurred at sorafenib 800 mg and cisplatin 20 mg/m(2)...
March 8, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28272911/effect-of-cruciferous-vegetable-intake-on-oxidative-stress-biomarkers-differences-by-breast-cancer-status
#6
Michael D Wirth, E Angela Murphy, Thomas G Hurley, James R Hébert
This post hoc analysis examined cruciferous vegetable intake on urinary oxidative metabolites in postmenopausal women. Intervention participants (n = 69) received cruciferous vegetables (≥14 cups/week) during a 3-week period. First morning urine measured 8-isoprostane and 8-hydroxy-2'-deoxyguanosine. Dietary intake was estimated using 24-h recalls. When stratified by history of breast cancer, those with breast cancer had significantly lower post-intervention urinary 8-hydroxy-2'-deoxyguanosine values in the intervention arm versus...
March 8, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28301252/identification-of-optimal-reference-genes-for-normalization-of-rt-qpcr-data-in-cancerous-and-non-cancerous-tissues-of-human-uterine-cervix
#7
COMPARATIVE STUDY
Shing Cheng Tan, Mohd Pazudin Ismail, Daniel Roza Duski, Nor Hayati Othman, Venkata Murali Krishna Bhavaraju, Ravindran Ankathil
This study aimed to identify the most stably expressed reference genes from a panel of 32 candidate genes for normalization of reverse transcription-quantitative real-time polymerase chain reaction data in cancerous and non-cancerous tissues of human uterine cervix. Overall, PUM1, YWHAZ, and RPLP0 were identified as the most stably expressed genes in paired cancerous and non-cancerous tissues. The results were further stratified by the state of malignancy of the tissues, histopathological type of the cancer, and the human papillomavirus-type...
March 16, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28301251/chrysin-as-an-anti-cancer-agent-exerts-selective-toxicity-by-directly-inhibiting-mitochondrial-complex-ii-and-v-in-cll-b-lymphocytes
#8
Ahmad Salimi, Mehryar Habibi Roudkenar, Enayatollah Seydi, Leila Sadeghi, Alireza Mohseni, Nahal Pirahmadi, Jalal Pourahmad
We investigated the effect of chrysin on isolated normal and chronic lymphocytic leukemia (CLL) B-lymphocytes and their isolated mitochondria. We report that a selective and significant increase in cytotoxicity, intracellular reactive oxygen species, mitochondrial membrane potential collapse, ADP/ATP ratio, caspase 3 activation and finally apoptosis in chrysin-treated CLL B- lymphocytes. Also we determined that chrysin selectively inhibits complex II and ATPases in cancerous mitochondria. In this study we proved that the ability of chrysin to promote apoptosis in CLL B-lymphocytes performed by selectively targeting of mitochondria...
March 16, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28267402/cd40-ligand-is-increased-in-mast-cells-in-psoriasis-and-actinic-keratosis-but-less-so-in-epithelial-skin-carcinomas
#9
Salla Haimakainen, Antti P Kaukinen, Mireille-Maria Suttle, Jukka Pelkonen, Ilkka T Harvima
The expression of CD40 ligand (CD40L) in mast cells was investigated in biopsies from lesional and non-lesional skin samples of patients with psoriasis, actinic keratosis (AK), basal cell carcinoma, and squamous cell carcinoma using a sequential double-staining technique. The percentage of CD40L(+) mast cells was higher in the lesional than in the non-lesional skin (p < .003). Interestingly, this percentage was lower in both carcinomas than in psoriasis and actinic keratosis (p < .025). Cells immunopositive for CD40 receptor were increased in all lesion types but especially so in carcinomas...
March 16, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28267394/downregulation-of-mir-377-promotes-oral-squamous-cell-carcinoma-growth-and-migration-by-targeting-hdac9
#10
Bhawna Rastogi, Amit Kumar, Satish K Raut, Naresh K Panda, Vidya Rattan, Nainesh Joshi, Madhu Khullar
microRNAs are the post-transcriptional regulators implicated in the initiation and progression of various cancer types, including oral squamous cell carcinoma (OSCC). Here, we investigated the role of miR-377 in OSCC tumorigenesis. miR-377 expression was reduced in OSCC samples and cell line (UPCI-SCC-116), and was associated with patient survival. In vitro restoration of miR-377 repressed cell growth, induced apoptosis, and reduced cell migration. We identified HDAC9 as a target of miR-377 and found miR-377 to regulate HDAC9 and its pro-apoptotic target, NR4A1/Nur77...
March 16, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28165839/targeting-vegfr-2-in-metastatic-gastric-cancer-results-from-a-literature-based-meta-analysis
#11
Giandomenico Roviello, Karol Polom, Franco Roviello, Daniele Marrelli, Andrea Giovanni Multari, Giovanni Paganini, Chiara Pacifico, Daniele Generali
Angiogenesis is a key process in cancer development. We performed a meta-analysis to assess the efficacy and safety of the novel VEGFR-2 inhibitors in patients with metastatic gastric and gastroesophageal junction cancer. A literature-based meta-analysis of randomized controlled trials (RCTs) was undertaken. The primary outcome was the overall survival. The pooled analysis from RCTs on anti-VEGFR-2 inhibitors revealed a significant increase in overall survival (hazard ratio for death: 0.69, 95% confidence interval: 0...
March 16, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28165774/factors-and-costs-associated-with-delay-in-treatment-initiation-and-prolonged-length-of-stay-with-inpatient-epoch-chemotherapy-in-patients-with-hematologic-malignancies
#12
Melissa K Accordino, Jason D Wright, Sowmya Vasan, Alfred I Neugut, Grace C Hillyer, Dawn L Hershman
Reducing delays related to inpatient chemotherapy may reduce healthcare costs. Using a national database, we identified patients with lymphoma/leukemia with ≥1 etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone (EPOCH) chemotherapy claim and evaluated chemotherapy initiation delay (ID), >1 day from admission. Standard tests/procedures prior to initiation were evaluated. Among 4453 inpatient cycles, 19.7% had ID, odds ratio 2.28 (95% confidence interval: 1.83-2.85) with cycle 1 compared to cycle 2, and mean costs were higher in patients with ID than without ID (p < ...
March 16, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28112977/early-prognostic-value-of-monitoring-serum-free-light-chain-in-patients-with-multiple-myeloma-undergoing-autologous-stem-cell-transplantation
#13
Zübeyde Nur Özkurt, Gülsan Türköz Sucak, Şahika Zeynep Akı, Münci Yağcı, Rauf Haznedar
We hypothesized the levels of free light chains obtained before and after autologous stem cell transplantation can be useful in predicting transplantation outcome. We analyzed 70 multiple myeloma patients. Abnormal free light chain ratios before stem cell transplantation were found to be associated early progression, although without any impact on overall survival. At day +30, the normalization of levels of involved free light chain related with early progression. According to these results almost one-third reduction of free light chain levels can predict favorable prognosis after autologous stem cell transplantation...
March 16, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28135863/evaluation-of-tc-99m-3prgd2-integrin-receptor-imaging-in-the-differential-diagnosis-of-breast-lesions-and-comparison-with-mammography
#14
COMPARATIVE STUDY
Guibing Chen, Zhong Ouyang, Fan Wang, Hua Wu, Bing Jia, Mahendra D Chordia
PURPOSE: The aims of this study were to evaluate and compare efficacies of Tc-99m-3PRGD2 integrin receptor imaging under variety of conditions for the diagnosis of breast lesions, in addition to comparison with mammography. MATERIALS AND METHODS: Seventy-two female patients with established breast lesions were recruited. All patients were examined by Tc-99m-3PRGD2 integrin receptor imaging and mammography. Whole-body scan and SPECT/CT were acquired at dual time points of 2 and 4 h after injection using standard protocol...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28135860/altered-expression-of-sphingosine-1-phosphate-metabolizing-enzymes-in-oral-cancer-correlate-with-clinicopathological-attributes
#15
Supriya Vishwakarma, Rahul Agarwal, Sudhir K Goel, Rajendra K Panday, Renu Singh, Ravi Sukumaran, Sarita Khare, Ashok Kumar
We have determined the gene expression of sphingosine-1-phosphate (S1P) metabolizing enzymes (SphK1, SphK2, SGPL1, SGPP1, SGPP2, PPAP2A, PPAP2B, and PPAP2C) by quantitative real-time polymerase chain reaction in tumor tissues and adjacent normal tissues of 50 oral squamous cell carcinoma (OSCC) patients. Expression of SphK1 and SGPP1 genes was up-regulated significantly in 70% and 75% OSCC tumors respectively. Importantly, expression of SphK2 and PPAP2B was down-regulated in the tumor tissues of 70% OSCC patients...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28135856/promoter-hypermethylation-and-its-impact-on-expression-of-mgmt-gene-in-the-git-malignant-patients-of-kashmiri-origin
#16
Arif Akbar Bhat, Hilal Ahmad Wani, Shiekh Ishaq, Ajaz Ahmad Waza, Rawoof Ahmad Malik, Iram Shabir, Showkat Jeelani, Showkat Kadla, Waseem Qureshie, Akbar Masood, Sabhiya Majid
Epigenetic alterations, in addition to multiple gene abnormalities, are involved in the genesis and progression of human cancers. Gastrointestinal tract (GIT) cancer is a major medical and economic burden worldwide. Aberrant methylation of CpG islands within promoter regions is associated with transcriptional inactivation of various tumor suppressor genes. Although a number of cancer-associated genes have been found to be hypermethylated in GIT cancer, valuable methylation markers for early diagnosis and prognostic evaluation of this cancer remain largely unknown...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28118074/gper-promoter-methylation-controls-gper-expression-in-breast-cancer-patients
#17
Christine Weissenborn, Tanja Ignatov, Norbert Nass, Thomas Kalinski, Serban Dan Costa, Ana Claudia Zenclussen, Atanas Ignatov
Recently, we found that G-protein-coupled estrogen receptor (GPER) protein expression decreased during breast carcinogenesis, and that GPER promoter is methylated. Here we analyzed GPER promoter methylation in 260 primary breast cancer specimens by methylation-specific polymerized chain reaction. The results demonstrated that GPER protein down-regulation significantly correlated with GPER promoter hypermethylation (p < .001). Comparison of 108 tumors and matched normal breast tissues indicated a significant GPER down-regulation in cancer tissues correlating with GPER promoter hypermethylation (p < ...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28107084/can-diffusion-weighted-imaging-and-related-apparent-diffusion-coefficient-be-a-prognostic-value-in-women-with-breast-cancer
#18
Paola Rabasco, Rocchina Caivano, Vittorio Simeon, Giuseppina Dinardo, Antonella Lotumolo, Matilde Gioioso, Antonio Villonio, Giancarlo Iannelli, Felice D'Antuono, Alexis Zandolino, Luca Macarini, Giuseppe Guglielmi, Aldo Cammarota
PURPOSE: To analyze diffusion-weighted imaging (DWI) and the related apparent diffusion coefficient (ADC) in women with breast cancer, correlating these values with the presence at 3 years of distant metastases, and to demonstrate that DWI-Magnetic Resonance Imaging (MRI) and related ADC values may represent a prognostic value in the study of women with breast cancer. MATERIALS AND METHODS: Sixty women (aged 45-73 years) affected with breast cancer with a follow-up in 3 years were enrolled...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28103112/potassium-iodate-differently-regulates-the-proliferation-migration-and-invasion-of-human-thyroid-cancer-cells-via-modulating-mir-146a
#19
Yan Liu, Hong Li, Jiayue Zhang, Xu Gao
The effects of different doses of potassium iodate (KIO3) on the malignancy of thyroid cancer were investigated. Results showed that the proliferation, migration, and invasion of SW579 thyroid cancer cells were improved by 10(-6) M KIO3, which was associated with microRNA(miR)-146a deficit; 10(-2) M KIO3 significantly enhanced miR-146a level and suppressed SW579 cell proliferation, migration, and invasion. The diverse effects of KIO3 on SW579 cells were associated with the expression changes in miR-146a targets, Bcl-2, Bax, and caspase-3...
February 7, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28102711/higher-expression-of-ercc1-may-be-associated-with-resistance-to-adjuvant-platinum-based-chemotherapy-in-gastric-cancer
#20
Jiayi Wan, Lin Chao, Arier C Lee, Qi Chen
Potential predictive biomarker(s) to respond to chemotherapy in gastric cancer are unclear. Excision repair cross-complementing 1 (ERCC1), a DNA repair enzyme, is associated with clinical outcomes in gastric cancer. Here, we investigated the expression of ERCC1 in gastric cancer with platinum-based chemotherapy after surgery, and the association between ERCC1 expression and clinical parameters was analyzed. Our data showed that high levels of ERCC1 expression were positively associated with resistance to platinum-based chemotherapy but not with lymph node metastasis and pathological stage...
February 7, 2017: Cancer Investigation
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