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Journal of Hypertension

Toshihiro Shoji, Atsushi Nakagomi, Sho Okada, Yuji Ohno, Yoshio Kobayashi
BACKGROUND: Studies have established the prognostic value of central SBP and pulse pressure (PP). The SphygmoCor XCEL (AtCor Medical, Sydney, Australia) device provides practical central blood pressure (BP) measurement for daily clinical use with its easy-to-use, operator-independent procedure. However, this device has not been validated against invasive measurement. METHOD: Simultaneous oscillometric and high-fidelity invasive measurements of central SBP and PP were compared for 36 patients who underwent coronary arteriography...
October 19, 2016: Journal of Hypertension
Rafael O Alvim, Andréa R V R Horimoto, Camila M Oliveira, Luiz A Bortolotto, José E Krieger, Alexandre C Pereira
BACKGROUND: Increased arterial stiffness is an important determinant of cardiovascular disease risk. In addition, it has been recognized that arterial stiffness has familial aggregation; however, there are no studies involving Brazilian families. Thus, the aim of this study was to evaluate the heritability of arterial stiffness in a Brazilian population. METHODS: In this study, 1675 eligible individuals (both sexes and aged 18-102 years) were distributed in 125 families resident in the municipality of Baependi, a city located in the southeast of Brazil...
October 19, 2016: Journal of Hypertension
Ana Rosa Cunha, Jenifer D'El-Rei, Fernanda Medeiros, Bianca Umbelino, Wille Oigman, Rhian M Touyz, Mario F Neves
BACKGROUND: Epidemiological studies demonstrate an inverse association between serum magnesium and incidence of cardiovascular disease. Diuretics commonly cause hypomagneseamia. METHOD: We evaluated effects of magnesium supplementation on blood pressure (BP) and vascular function in thiazide-treated hypertensive women in a randomized, double-blind, clinical trial. Hypertensive women (40-65 years) on hydrochlorothiazide and mean 24-h BP at least 130/80 mmHg were divided into placebo and supplementation (magnesium chelate 600 mg/day) groups...
October 18, 2016: Journal of Hypertension
Jonathan G Moss, Anna-Maria Belli, Antonio Coca, Michael Lee, Giuseppe Mancia, Jan H Peregrin, Josep Redon, Jim A Reekers, Costas Tsioufis, Dierk Vorwerk, Roland E Schmieder
Renal denervation (RDN) was reported as a novel exciting treatment for resistant hypertension in 2009. An initial randomized trial supported its efficacy and the technique gained rapid acceptance across the globe. However, a subsequent large blinded, sham arm randomized trial conducted in the USA (to gain Food and Drug Administration approval) failed to achieve its primary efficacy end point in reducing office blood pressure at 6 months. Published in 2014 this trial received both widespread praise and criticism...
October 17, 2016: Journal of Hypertension
H H Caline Koh-Tan, Mohammed Dashti, Ting Wang, Wendy Beattie, John Mcclure, Barbara Young, Anna F Dominiczak, Martin W Mcbride, Delyth Graham
BACKGROUND: We have previously confirmed the importance of rat chromosome 3 (RNO3) genetic loci on blood pressure elevation, pulse pressure (PP) variability and renal pathology during salt challenge in the stroke-prone spontaneously hypertensive (SHRSP) rat. The aims of this study were to generate a panel of RNO3 congenic sub-strains to genetically dissect the implicated loci and identify positional candidate genes by microarray expression profiling and analysis of next-generation sequencing data...
October 17, 2016: Journal of Hypertension
Liv Cecilie V Thomsen, Nina S Mccarthy, Phillip E Melton, Gemma Cadby, Rigmor Austgulen, Ottar K Nygård, Matthew P Johnson, Shaun Brennecke, Eric K Moses, Line Bjørge, Ann-Charlotte Iversen
OBJECTIVE: Preeclampsia is a complex heterogeneous disease commonly defined by new-onset hypertension and proteinuria in pregnancy. Women experiencing preeclampsia have increased risk for cardiovascular diseases (CVD) later in life. Preeclampsia and CVD share risk factors and pathophysiologic mechanisms, including dysregulated inflammation and raised blood pressure. Despite commonalities, little is known about the contribution of shared genes (pleiotropy) to these diseases. This study aimed to investigate whether genetic risk factors for hypertension or inflammation are pleiotropic by also being associated with preeclampsia...
October 17, 2016: Journal of Hypertension
George C Roush, Brigani Amante, Tanveer Singh, Hiwot Ayele, Morakinyo Araoye, Danwen Yang, William J Kostis, William J Elliott, John B Kostis, Jesse A Berlin
OBJECTIVES: Doubling on average every 6 years, hypertension-related meta-analyses are now published twice weekly and are often considered the highest level of evidence for clinical practice. However, some hypertension specialists and guideline authors view meta-analyses with skepticism. This article evaluates the quality of hypertension-related meta-analyses of clinical trials. METHODS: A systematic search was conducted for meta-analyses of clinical trials recently published over 3...
October 17, 2016: Journal of Hypertension
Michael Böhm, Christian Ukena, Sebastian Ewen, Dominik Linz, Ina Zivanovic, Uta Hoppe, Krzysztof Narkiewicz, Luis Ruilope, Manuela Negoita, Roland Schmieder, Bryan Williams, Uwe Zeymer, Andreas Zirlik, Guiseppe Mancia, Felix Mahfoud
OBJECTIVES: Renal denervation (RDN) can reduce sympathetic activity and blood pressure (BP) in patients with hypertension. The effects on resting and ambulatory heart rate (HR), also regulated by the sympathetic nervous system, are not established. METHODS: Herein, we report 12-month outcomes from the Global SYMPLICITY Registry on office and ambulatory HR and BP in patients with uncontrolled hypertension (n = 846). RESULTS: HR declined in correlation with the HR at baseline and at 12 months, in particular, in patients in the upper tertile of HR (>74 bpm)...
October 15, 2016: Journal of Hypertension
Margarida Mendes, Julie Dubourg, Anne Blanchard, Damien Bergerot, Pierre-Yves Courand, Valentina Forni, Michael Frank, Guillaume Bobrie, Joel Menard, Michel Azizi
OBJECTIVES: The participation of vasopressin in the mechanisms of resistant hypertension is unclear. We compared plasma copeptin concentration, a surrogate marker for vasopressin secretion, between patients with resistant hypertension and those with controlled blood pressure (CBP), in a post hoc analysis of the Prise en charge de l'Hypertension Artérielle RESistante au traitement trial. METHODS: After 4-week treatment with irbesartan 300 mg/day, hydrochlorothiazide 12...
October 15, 2016: Journal of Hypertension
Claire Johnson, Devarsetty Praveen, Alun Pope, Thout S Raj, Rakesh N Pillai, Mary Anne Land, Bruce Neal
BACKGROUND: Member states of the WHO, including India, have adopted a target 30% reduction in mean population salt consumption by 2025 to prevent noncommunicable diseases. Our aim was to support this initiative by summarizing existing data that describe mean salt consumption in India. METHOD: Electronic databases - MEDLINE via Ovid, EMBASE, CINAHL and the Cochrane Database of Systematic Reviews - were searched up to November 2015 for studies that reported mean or median dietary salt intake in Indian adults aged 19 years and older...
October 15, 2016: Journal of Hypertension
Yasuharu Tabara, Michiya Igase, Tetsuro Miki, Yasumasa Ohyagi, Fumihiko Matsuda, Katsuhiko Kohara
OBJECTIVE: Loss of the nocturnal blood pressure (BP) drop is a risk factor for cardiovascular outcomes. However, clinical parameters that predispose to changes in nocturnal BP are currently uncertain. Given the possible involvement of salt sensitivity in nocturnal BP levels, we investigated a hypothesized association between plasma B-type natriuretic peptide (BNP) levels - a marker of body fluid retention - and nocturnal BP in a general population. METHODS: Study participants were 1020 general individuals...
October 7, 2016: Journal of Hypertension
Tove Bokrantz, Charlotta Ljungman, Thomas Kahan, Kristina B Boström, Jan Hasselström, Per Hjerpe, Dan Mellström, Linus Schiöler, Karin Manhem
OBJECTIVE: The objective is to investigate if treatment with thiazides reduces the risk of osteoporotic fractures in hypertensive patients in primary healthcare. Further we aimed to examine the impact of duration of thiazide use, the consequences of discontinuation of treatment, and the possible difference in effect between men and women. METHOD: This retrospective cohort study includes 57 822 individuals, 45 years and older, diagnosed with hypertension during 2001-2008 in the Swedish Primary Care Cardiovascular Database...
October 5, 2016: Journal of Hypertension
Puttarin Kulchaitanaroaj, John M Brooks, Nathorn Chaiyakunapruk, Amber M Goedken, Elizabeth A Chrischilles, Barry L Carter
OBJECTIVE: To estimate long-term costs and outcomes attributable to a physician-pharmacist collaborative intervention compared with physician management alone for treating essential hypertension. METHODS: A Markov model cohort simulation with a 6-month cycle length to predict acute coronary syndrome, stroke, and heart failure throughout lifetime was performed. A cohort of 399 patients was obtained from two prospective, cluster randomized controlled clinical trials implementing physician-pharmacist collaborative interventions in community-based medical offices in the Midwest, USA...
September 28, 2016: Journal of Hypertension
Paul A Camacho, Diego Gomez-Arbelaez, Dora I Molina, Gregorio Sanchez, Edgar Arcos, Claudia Narvaez, Henry García, Maritza Pérez, Erick A Hernandez, Myriam Duran, Carlos Cure, Aristides Sotomayor, Alvaro Rico, Tannia M David, Daniel D Cohen, Sumathy Rangarajan, Salim Yusuf, Patricio Lopez-Jaramillo
OBJECTIVE: Hypertension is the principal risk factor for cardiovascular diseases. The global Prospective Urban Rural Epidemiology study showed that the levels of awareness, treatment and control of this condition are very low worldwide and show large regional variations related to a country's income index. The aim of the present analysis was to identify associations between sociodemographic, geographic, anthropometric, behavioral and clinical factors and the awareness, treatment and control of hypertension within Colombia - a high-middle income country which participated in the global Prospective Urban Rural Epidemiology study...
September 22, 2016: Journal of Hypertension
Rebeca Cipriano Braga Silva, Diego Augusto da Silva, João Luiz Dornelles Bastos, Karen Glazer Peres, Marco Peres, David Alejandro González-Chica
OBJECTIVE: The objective was to evaluate the effects of BMI and waist circumference change on the cumulative incidence of high blood pressure levels (HBP) among adults. METHODS: Prospective longitudinal study in Southern Brazil, with a sample evaluated in 2009 (n = 1720) and 2012 (n = 1213). The incidence of HBP was estimated using measured values of systolic and diastolic arterial pressure (≥140/90 mmHg). RESULTS: The prevalence of overweight (BMI ≥ 25 kg/m) was 47...
September 22, 2016: Journal of Hypertension
Maria L Muiesan, Massimo Salvetti, Augusto Di Castelnuovo, Anna Paini, Deodato Assanelli, Simona Costanzo, Fabio Badilini, Martino Vaglio, Maria B Donati, Enrico Agabiti Rosei, Giovanni de Gaetano, Licia Iacoviello
AIM: Our aim was to investigate the prevalence and the prognostic significance for fatal and nonfatal cerebrovascular and cardiovascular events of different ECG criteria for left ventricular hypertrophy (LVH) in normal weight, overweight and obese patients in an adult Italian population. METHODS: A total of 18 330 adults (mean age 54 ± 11 years, 55% women, 53% hypertensive patients) were analyzed from the Moli-sani cohort. Obesity was defined using the ATPIII criteria...
September 22, 2016: Journal of Hypertension
Yinkun Yan, Dongqing Hou, Junting Liu, Xiaoyuan Zhao, Hong Cheng, Bo Xi, Jie Mi
OBJECTIVE: Atherosclerosis and arterial stiffness predict cardiovascular morbidity and mortality. We aimed to investigate the influence of BMI and blood pressure (BP) in childhood, and change in BMI and BP, on the development of subclinical atherosclerosis and arterial stiffness in adulthood. METHODS: The study consisted of 1256 individuals aged 27-42 years who had 2-10 measurements of BMI and BP from childhood. In the final survey (2010-2011), subclinical markers of vascular damage, including carotid intima-media thickness (cIMT), carotid-femoral pulse wave velocity (cfPWV), and brachial-ankle pulse wave velocity (baPWV), were measured...
September 17, 2016: Journal of Hypertension
Rachel M Zack, Kahema Irema, Patrick Kazonda, Germana H Leyna, Enju Liu, Donna Spiegelman, Wafaie Fawzi, Marina Njelekela, Japhet Killewo, Goodarz Danaei
OBJECTIVES: We assessed the prevalence and determinants of high blood pressure (BP), and barriers to diagnosis and treatment, in Dar es Salaam, Tanzania. METHODS: We surveyed and screened 2174 community-dwelling adults aged at least 40 years in 2014 and conducted a follow-up after 1 year. RESULTS: Median BP was 131/81 mmHg, and hypertension prevalence was 37%. Mean adjusted difference in SBP was 4.0 mmHg for overweight, 6.3 mmHg for obese class I, and 10...
September 17, 2016: Journal of Hypertension
Claire McDonald, Mark S Pearce, Simon R J Kerr, Julia L Newton
BACKGROUND: Cognitive impairment is common in later life. Identifying potential modifiable risk factors for cognitive decline may ameliorate the burden of disease. Cross-sectional studies show an association between blood pressure (BP) variability and impaired cognitive function in patients with hypertension and/or dementia. However, research examining the association between BP variability and cognitive function in the general older population is scarce. OBJECTIVE: In this study, we examined the association between BP variability and cognitive function over 5-year follow-up in an unselected community-dwelling cohort...
September 17, 2016: Journal of Hypertension
Angela Tagetti, Sara Bonafini, Marco Zaffanello, Maria V Benetti, Francesco Dalle Vedove, Emma Gasperi, Paolo Cavarzere, Rossella Gaudino, Giorgio Piacentini, Pietro Minuz, Claudio Maffeis, Franco Antoniazzi, Cristiano Fava
INTRODUCTION: Both sleep-disordered breathing (SDB) and high blood pressure (BP) occur more frequently among obese children than among normal weight children, and this may be due to endothelial dysfunction and worsened arterial stiffness. The aim of this study was to evaluate the possible association between SDB and BP, and the possible role of endothelial function and local and systemic arterial stiffness in a sample of obese children asymptomatic for sleep disturbances. MATERIALS AND METHODS: Thirty-nine obese children were included in the study...
September 17, 2016: Journal of Hypertension
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