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Journal of Hypertension

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https://www.readbyqxmd.com/read/28106665/effects-of-multielectrode-renal-denervation-on-elevated-sympathetic-nerve-activity-and-insulin-resistance-in-metabolic-syndrome
#1
Costas Tsioufis, Kyriakos Dimitriadis, Alexandros Kasiakogias, Theodore Kalos, Ioannis Liatakis, Evagelia Koutra, Levki Nikolopoulou, Athanasios Kordalis, Rita Omega Ella, Elizabeth Oi-Yan Lau, Guido Grassi, Vasilios Papademetriou, Dimitrios Tousoulis
OBJECTIVE: This study aimed to investigate the effects of renal denervation (RDN) on sympathetic nerve activity and insulin resistance in patients with metabolic syndrome. METHODS: Seventeen patients fulfilled at least four of five criteria for metabolic syndrome and under stable use of at least two antihypertensive drugs were randomized in 3 : 1 ratio to RDN (n = 13, 12 men, age: 58 ± 7 years) and control groups (n = 4, three men, age: 60 ± 5 years) and followed up for 3 months...
January 18, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28106664/ethnic-differences-regarding-arterial-stiffness-of-6-8-year-old-black-and-white-boys
#2
Gontse G Mokwatsi, Aletta E Schutte, Ruan Kruger
OBJECTIVES: Vascular deterioration is suggested to occur earlier in black than white populations, thereby increasing their risk for developing hypertension. To establish whether this is the case, we compared different estimates of arterial stiffness in black and white children and investigated the links with body composition and advanced glycation end products (AGEs) as potential contributors. METHODS: We included 40 black and 41 white boys (aged 6-8 years) from similar schools and measured arterial stiffness [pulse wave velocity (PWV) in different arterial sections, systemic arterial compliance and carotid stiffness estimates], anthropometry as well as urinary pentosidine as a marker of AGEs...
January 18, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28106663/the-role-of-laser-doppler-flowmetry-tests-serum-angiopoietin-2-asymmetric-and-symmetric-dimethylarginine-to-predict-outcome-in-chronic-kidney-disease
#3
János Nemcsik, Orsolya Cseprekál, József Egresits, Jan Kielstein, Philipp Kümpers, Alexander Lukasz, Ádám Tabák, Adrienn Marton, Zsófia K Németh, Zoltán Járai, Gabriella Godina, László Sallai, Katalin Farkas, István Kiss, András Tislér
OBJECTIVE: The role of biochemical and functional markers of microvascular dysfunction to predict cardiovascular outcomes in nondialyzed chronic kidney disease (CKD) remains unclear. In this prospective cohort study, we assessed whether biochemical [serum level of angiopoietin-2 (Ang-2), asymmetric and symmetric dimethylarginin] and functional (laser Doppler flowmetry) measures of microvascular function predicted cardiovascular events, cardiovascular and all-cause mortality in CKD patients...
January 18, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28106662/medication-adherence-interventions-among-hypertensive-black-adults-a-systematic-review-and-meta-analysis
#4
Todd M Ruppar, Jacqueline M Dunbar-Jacob, David R Mehr, Lisa Lewis, Vicki S Conn
BACKGROUND: Black adults have higher rates of hypertension and lower rates of blood pressure (BP) control than white adults. Improving BP control requires attention to use of antihypertensive medications, but antihypertensive regimen adherence remains low, preventing improved BP control. METHODS AND RESULTS: We conducted a comprehensive search and systematic review of intervention studies testing interventions to improve adherence to BP medications among black adults with hypertension...
January 18, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28099195/systolic-peak-foot-to-apex-time-interval-a-novel-oscillometric-technique-for-systolic-blood-pressure-measurement
#5
Amir M Benmira, Antonia Perez-Martin, Sarah Coudray, Iris Schuster, Isabelle Aichoun, Jérémy Laurent, Fethi Bereski-Reguig, Michel Dauzat
BACKGROUND: Noninvasive blood pressure (BP) measurement is essential for the study of human physiology but automatic oscillometric devices only estimate SBP and DBP using various, undisclosed algorithms, precluding standardization and interchangeability. We propose a novel approach by tracking, during pneumatic cuff deflation, the time interval from the foot to the apex of the systolic peak of the oscillometric signal, which reaches a maximum concomitant with the first Korotkoff sound...
January 17, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28092279/association-between-long-term-blood-pressure-control-and-ten-year-progression-in-carotid-arterial-stiffness-among-hypertensive-individuals-the-multiethnic-study-of-atherosclerosis
#6
Yacob G Tedla, Adam D Gepner, Dhananjay Vaidya, Laura Colangelo, James H Stein, Kiang Liu, Philip Greenland
BACKGROUND: Arterial stiffness was shown to be higher among hypertensive patients with diabetes than those without diabetes and among older than younger hypertensive patients. We examined whether the association between long-term blood pressure (BP) control and 10-year progression in carotid arterial stiffness varies by diabetes status and age. METHODS: Participants were 906 individuals with hypertension at baseline and three follow-up visits in the Multi-Ethnic Study of Atherosclerosis (mean age 63...
January 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28079596/statistical-analysis-as-a-cause-of-white-coat-hypertension
#7
Martin G Myers
No abstract text is available yet for this article.
January 12, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28079595/acetylated-cyclophilin-a-is-a-major-mediator-in-hypoxia-induced-autophagy-and-pulmonary-vascular-angiogenesis
#8
Min Mao, Xiufeng Yu, Xin Ge, Rui Gu, Qian Li, Shasha Song, Xiaodong Zheng, Tingting Shen, Xuecang Li, Yao Fu, Jiali Li, Daling Zhu
BACKGROUND: Autophagy is a major intracellular degradation and recycling process that maintains cellular homeostasis, which is involved in structural and functional abnormalities of pulmonary vasculature in hypoxic pulmonary arterial hypertension (HPAH). Cyclophilin A (CyPA) is a secreted, oxidative stress-induced factor. Its role in inducing autophagy and augmenting endothelial cell dysfunction has never been explored. METHODS: Lungs from rats exposed to chronic hypoxia were examined for autophagy with electron microscopy, western blotting, and fluorescence microscopy...
January 12, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28060190/pathophysiological-differences-between-multifocal-fibromuscular-dysplasia-and-atherosclerotic-renal-artery-stenosis
#9
Daan J L van Twist, Alfons J H M Houben, Michiel W de Haan, Peter W de Leeuw, Abraham A Kroon
BACKGROUND: Fibromuscular dysplasia (FMD) and atherosclerotic renal artery stenosis (ARAS) are the most common causes of renovascular hypertension. So far, FMD is believed to cause hypertension via similar mechanisms as in ARAS, that is, a decrease in renal blood flow, which subsequently leads to increased renin secretion. However, given the differences in the blood pressure (BP)-lowering effect of revascularization between patients with ARAS and FMD, we questioned whether this is true...
January 5, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28060189/associations-of-risk-factors-in-childhood-with-arterial-stiffness-26-years-later-the-hanzhong-adolescent-hypertension-cohort
#10
Chao Chu, Yi Dai, Jianjun Mu, Ruihai Yang, Man Wang, Jun Yang, Yong Ren, Bingqing Xie, Zhenzhen Dong, Fan Yang, Dan Wang, Dingyi Yan, Tong-Shuai Guo, Yang Wang
OBJECTIVE: The relationship between childhood risk factors and long-term arterial stiffness was explored. METHODS: A baseline survey was conducted in 4623 school children aged 6-15 years in rural areas of Hanzhong city, Shaanxi, in 1987. According to three independent measurements of SBP in 1987, 1989, and 1992, cases of the same age and sex with continuous SBP at least 75 percentile were classified as the high-blood pressure (BP) group, whereas those with SBP less than 50 percentile were classified as the normal-BP group...
January 5, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28060188/prox1-gene-cc-genotype-as-a-major-determinant-of-early-onset-of-type-2-diabetes-in-slavic-study-participants-from-action-in-diabetes-and-vascular-disease-preterax-and-diamicron-mr-controlled-evaluation-study
#11
Pavel Hamet, Mounsif Haloui, François Harvey, François-Christophe Marois-Blanchet, Marie-Pierre Sylvestre, Muhammad-Ramzan Tahir, Paul H G Simon, Beatriz Sonja Kanzki, John Raelson, Carole Long, John Chalmers, Mark Woodward, Michel Marre, Stephen Harrap, Johanne Tremblay
BACKGROUND: The prevalence of diabetic nephropathy varies according to ethnicity. Environmental as well as genetic factors contribute to the heterogeneity in the presentation of diabetic nephropathy. Our objective was to evaluate this heterogeneity within the Caucasian population. METHODS: The geo-ethnic origin of the 3409 genotyped Caucasian type 2 diabetes (T2D) patients of Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation was determined using principal component analysis...
January 5, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28060187/cumulative-in-trial-and-post-trial-effects-of-blood-pressure-and-lipid-lowering-systematic-review-and-meta-analysis
#12
Yoichiro Hirakawa, Hisatomi Arima, Anthony Rodgers, Mark Woodward, John Chalmers
OBJECTIVE: Persistent long-term benefits after discontinuation of treatment have been suggested for blood pressure-lowering and lipid-lowering treatment. We conducted a systematic review to assess the long-term effects of blood pressure (BP) lowering (BPL) and lipid lowering on all-cause and cardiovascular mortality after discontinuation of randomized treatment. METHODS: We systematically searched Medline, Embase, and the Cochrane Central Register of Controlled Trials...
January 5, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28033131/blood-pressure-measurements-patterns-and-targets
#13
Alberto Zanchetti
No abstract text is available yet for this article.
December 28, 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/28033130/the-effect-of-vitamin-d-on-renin-angiotensin-system-activation-and-blood-pressure-a-randomized-control-trial
#14
Ciaran J McMullan, Lea Borgi, Gary C Curhan, Naomi Fisher, John P Forman
OBJECTIVE: Disruption of vitamin D signaling in rodents causes activation of the rennin-angiotensin system (RAS) and development of hypertension. Observational studies in humans found lower circulating 25-hydroxyvitamin D [25(OH)D] is associated with increased RAS activity and blood pressure (BP). We performed the first randomized control trial to investigate the effects of vitamin D supplementation on the RAS in humans. METHODS: Vitamin D deficient, [25(OH)D ≤20 ng/ml), overweight individuals without hypertension were randomized into a double-blind, placebo-controlled trial of 8-weeks treatment with ergocalciferol or placebo...
December 28, 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/28033129/new-oral-anticoagulants-and-prevention-of-thromboembolic-events-in-patients-with-hypertension-and-atrial-fibrillation-an-appraisal
#15
Claudio Borghi, Stefania Paolillo, Arrigo F G Cicero, Paola Gargiulo, Bruno Trimarco, Pasquale Perrone Filardi
Arterial hypertension (HTN) and atrial fibrillation often coexist and the combination of these two conditions carries an increased risk of stroke. HTN is one of the most important risk factors included in the scores for stoke prediction in atrial fibrillation used to assess the need of anticoagulation, and HTN has also been strictly related to bleeding complications of antithrombotic therapy. Antithrombotic drugs options include vitamin K antagonists, or new oral anticoagulants, recently approved for stroke prevention in nonvalvular atrial fibrillation...
December 28, 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/28033128/renal-function-of-cyclin-m2-mg2-transporter-maintains-blood-pressure
#16
Yosuke Funato, Daisuke Yamazaki, Hiroaki Miki
OBJECTIVES: Epidemiological studies have shown that magnesium intake/excretion is inversely correlated with blood pressure (BP), and artificial supplementation of magnesium was able to prevent hypertension. However, there has been no molecular genetic study showing the importance of magnesium homeostasis in BP regulation. METHODS: We analyzed magnesium content and BP of mice lacking genes encoding cyclin M (CNNM) Mg transporter family proteins. RESULTS: Systemic heterozygotes and the kidney-specific homozygotes for Cnnm2-deficient alleles are both viable and show hypomagnesemia, indicating the important function of CNNM2 in maintaining magnesium homeostasis in the kidney...
December 28, 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/28033127/meditation-and-blood-pressure-a-meta-analysis-of-randomized-clinical-trials
#17
Lu Shi, Donglan Zhang, Liang Wang, Junyang Zhuang, Rebecca Cook, Liwei Chen
OBJECTIVES: We meta-analyzed the effect of meditation on blood pressure (BP), including both transcendental meditation and non-transcendental meditation interventions. METHODS: We identified randomized controlled trials (RCTs) that examined the BP responses to meditation interventions through a systematic literature search of the PubMed, ABI/INFORM, MEDLINE, EMBASE, PsycINFO, and CINAHL databases (from January 1980 to October 2015). We meta-analyzed the change in SBP and DBP, stratified by type of meditation (transcendental meditation vs...
December 28, 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/28033126/shear-stress-mediated-upregulation-of-gtp-cyclohydrolase-tetrahydrobiopterin-pathway-ameliorates-hypertension-related-decline-in-reendothelialization-capacity-of-endothelial-progenitor-cells
#18
Yong-Ping Bai, Songhua Xiao, Yong-Bo Tang, Zhi Tan, Hailin Tang, Zhi Ren, Haitao Zeng, Zhen Yang
OBJECTIVES: Guanosine triphosphate cyclohydrolase/tetrahydrobiopterin (GTPCH)/(BH4) pathway has been proved to regulate the function of endothelial progenitor cells (EPCs) in deoxycorticosterone acetate-salt hypertensive mice, indicating that GTPCH/BH4 pathway may be an important repair target for hypertension-related endothelial injury. Shear stress is an important nonpharmacologic strategy to modulate the function of EPCs. Here, we investigated the effects of laminar shear stress on the GTPCH/BH4 pathway and endothelial repair capacity of circulating EPCs in hypertension...
December 28, 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/28030431/efficacy-and-safety-of-sacubitril-valsartan-lcz696-add-on-to-amlodipine-in-asian-patients-with-systolic-hypertension-uncontrolled-with-amlodipine-monotherapy
#19
Ji-Guang Wang, Kimihiko Yukisada, Antonio Sibulo, Kudsia Hafeez, Yan Jia, Jack Zhang
OBJECTIVE: The objective of this study is to evaluate the efficacy and safety of sacubitril/valsartan (LCZ696, an angiotensin receptor and neprilysin inhibitor) add-on to amlodipine compared with amlodipine monotherapy in Asian patients with systolic hypertension uncontrolled with amlodipine. METHODS: Patients with mean clinic SBP at least 145 mmHg and less than 180 mmHg after a 4-week treatment with amlodipine 5 mg/day were randomized to receive LCZ696/amlodipine (200/5 mg/day) or amlodipine 5 mg/day for 8 weeks...
December 24, 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/28030430/prestroke-treatment-with-beta-blockers-for-hypertension-is-not-associated-with-severity-and-poor-outcome-in-patients-with-ischemic-stroke-data-from-a-national-stroke-registry
#20
Silvia Koton, David Tanne, Ehud Grossman
BACKGROUND: Beta-blockers are not recommended as the initial therapy for hypertension. Reports on associations between use of beta-blockers and stroke severity are inconclusive. We assessed associations between prestroke use of beta-blockers and stroke severity, poststroke disability and death in a large group of hypertensive patients hospitalized with acute ischemic stroke. METHODS: All 3915 patients with ischemic stroke, treated prestroke for hypertension and registered in the National Acute Stroke ISraeli, were included...
December 24, 2016: Journal of Hypertension
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