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Journal of Hypertension

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https://www.readbyqxmd.com/read/29035944/association-between-common-carotid-artery-diameter-and-target-organ-damage-in-essential-hypertension
#1
Yan Yang, Yan Wang, Jianzhong Xu, Pingjin Gao
OBJECTIVES: To investigate the relationship between common carotid artery diameter (CCA-D) and target organ damage (TOD) in essential hypertension. METHODS AND RESULTS: A total of 200 essential hypertensive patients were enrolled (mean age 62.5 ± 9.5, men 59.0%) and were classified into two groups by the height-adjusted mean median of CCA-D: patients with CCA-D/height less than 3.905 mm/m (n = 100, 50%) and patients with CCA-D/height more than 3.905 mm/m (n = 100, 50%)...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29035943/metabolic-syndrome-and-subclinical-carotid-damage-a-meta-analysis-from-population-based-studies
#2
Cesare Cuspidi, Carla Sala, Fabio Provenzano, Marijana Tadic, Elisa Gherbesi, Guido Grassi, Giuseppe Mancia
AIM: Metabolic syndrome (MetS) is a phenotype of growing prevalence in the general population. Information on the association between MetS and vascular damage in this setting is only based on data provided by single reports. We performed a meta-analysis of population-based studies aimed to assess the association of MetS with carotid atherosclerosis. DESIGN: Studies were identified by the following search terms: 'metabolic syndrome', 'general population,' 'carotid intima-media thickness' (IMT), 'carotid atherosclerosis,' 'carotid damage,' 'ultrasonography...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29035942/phase-ii-randomized-sham-controlled-study-of-renal-denervation-for-individuals-with-uncontrolled-hypertension-wave-iv
#3
Roland E Schmieder, Christian Ott, Stefan W Toennes, Peter Bramlage, Michael Gertner, Omar Dawood, Peter Baumgart, Benjamin O'Brien, Indranil Dasgupta, Georg Nickenig, John Ormiston, Manish Saxena, Andrew S P Sharp, Horst Sievert, Jindrich Spinar, Zdenek Starek, Joachim Weil, Ulrich Wenzel, Adam Witkowski, Melvin D Lobo
OBJECTIVES: The aim of this double-blind, randomized, sham-controlled study was to verify the blood pressure (BP)-lowering efficacy of externally delivered focused ultrasound for renal denervation (RDN). BACKGROUND: Nonrandomized, first proof-of-concept study and experimental evidence suggested that noninvasive techniques of RDN emerged as an alternative approach of RDN to invasive technologies. METHODS: WAVE IV, an international, randomized (1 : 1) sham-controlled, double-blind prospective clinical study, was prematurely stopped...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29035941/arterial-stiffness-and-cardiometabolic-phenotype-of-cameroonian-pygmies-and-bantus
#4
William Ngatchou, Daniel Lemogoum, Christian Mélot, Virginie Guimfacq, Philippe van de Borne, Jean Claude Wautrecht, Michel P Hermans, Luc Van Bortel, Marc Leeman
BACKGROUND: Pygmies living in the Central African rainforest with a traditional hunter-gatherer lifestyle have a low incidence of cardiovascular diseases. Because of progressive loss of traditional habitat and ancestral lands, some Pygmies have migrated to urban areas and adopt specific Bantu lifestyles such as increased salt consumption and a sedentary way of life. We tested the hypothesis that migrant Pygmies could present with hemodynamic and metabolic characteristics different from those of traditional in-situ Pygmies and possibly closer to those of Bantu farmers...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29035940/perspectives-on-hypertension-s-prevalence-treatment-and-control-in-a-high-cardiovascular-risk-east-european-country-data-from-the-sephar-iii-survey
#5
Maria Dorobantu, Oana-Florentina Tautu, Doina Dimulescu, Crina Sinescu, Paul Gusbeth-Tatomir, Catalina Arsenescu-Gerogescu, Florin Mitu, Daniel Lighezan, Calin Pop, Katalin Babes, Alina Giuca, Ileana Branza, Mihaela Udrescu, Valeria Herdea, Roxana Darabont
OBJECTIVES: To estimate the trend in arterial hypertension's prevalence, awareness, treatment, and control in Romania, starting from the latest national survey Study for the Evaluation of Prevalence of Hypertension and Cardiovascular Risk in Romania III that has a crucial importance for the development of prevention strategies at national level. METHODS: A representative sample of 1970 Romanian adults (mean age 48.38 years, age range 18-80 years, 52.5% women, 72...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29035939/predictors-for-the-development-of-microalbuminuria-and-interaction-with-renal-function
#6
Christos Chatzikyrkou, Jan Menne, Joseph Izzo, Giancarlo Viberti, Ton Rabelink, Luis M Ruilope, Christian Rump, Peter R Mertens, Hermann Haller
AIM: It is important to know which factors predict the development of microalbuminuria in patients with diabetes mellitus type II. MATERIAL: Data from the Randomized Olmesartan and Diabetes Microalbuminuria Prevention Study were used to identify predictors for the new onset of microalbuminuria. Furthermore, the interaction of baseline albuminuria and baseline estimated glomerular filtration rate (eGFR) and the effects of treatment with olmesartan were investigated...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29016533/age-at-natural-menopause-and-hypertension-among-middle-aged-and-older-chinese-women
#7
Lulu Song, Lijun Shen, Hui Li, Bingqing Liu, Xiaoxuan Zheng, Lina Zhang, Yuan Liang, Jing Yuan, Youjie Wang
OBJECTIVES: Earlier age at natural menopause has been associated with cardiovascular disease in several studies, but evidence of its association with hypertension is lacking. We aimed to examine the relationship between age at natural menopause and hypertension among middle-aged and older Chinese women. METHODS: A total of 13 406 postmenopausal women (mean age 63.5 years) were enrolled from the Dongfeng-Tongji cohort study in Hubei province, China. Age at natural menopause was self-reported and was categorized into three groups (≤45, 46-52, or ≥53 years)...
October 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29016532/kcnj5-mutation-as-a-predictor-for-resolution-of-hypertension-after-surgical-treatment-of-aldosterone-producing-adenoma
#8
Takumi Kitamoto, Masao Omura, Sachiko Suematsu, Jun Saito, Tetsuo Nishikawa
OBJECTIVE: To investigate the effect of KCNJ5 mutations on the cure of hypertension in patients with aldosterone-producing adenoma (APA) after unilateral adrenalectomy. METHODS: Our study included 142 patients with APA, who were detected with an endocrinological abnormality and diagnosed with hypertension, as confirmed by pathological analysis. We sequenced KCNJ5, ATP1A1, ATP2B3, CACNA1D, and CTNNB1 from APA tissue samples, and performed a retrospective analysis to determine correlations between wild-type or mutated KCNJ5 and patient clinical characteristics...
October 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29016531/myocardial-preload-alters-central-pressure-augmentation-through-changes-in-the-forward-wave
#9
Lennart van de Velde, Daan W Eeftinck Schattenkerk, Pascale A H T Venema, Hendrik J Best, Bas van den Bogaard, Wim J Stok, Berend E Westerhof, Bert Jan H van den Born
OBJECTIVE: Augmentation index (AIx) is often used to quantify the contribution of wave reflection to central pulse pressure. Recent studies have challenged this view by showing how contractility-induced changes in the forward pressure wave can markedly impact AIx. We hypothesized that changes in preload will also affect AIx through changes in the forward wave and studied this in two experiments. METHODS: Noninvasively obtained aortic pressure was used to study central haemodynamics and wave morphology...
October 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28990987/standardization-according-to-blood-pressure-lowering-in-meta-analyses-of-antihypertensive-trials-comparison-of-three-methodological-approaches
#10
Mattias Brunström, Bo Carlberg
OBJECTIVE: Assess how standardization of relative risks (RRs) and standard errors (SEs), according to blood pressure differences within trials, affects heterogeneity, overall effect estimates and study weights in meta-analyses of antihypertensive treatment. METHOD: Data from a previous systematic review were used. Three sets of analyses were performed, using both random-effects and fixed-effects model for meta-analyses. First, we used raw data from the included trials...
October 4, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28968261/blood-vessels-and-the-kidney-in-hypertension
#11
Alberto Zanchetti
No abstract text is available yet for this article.
September 28, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28968260/central-antihypertensive-effects-of-chronic-treatment-with-rb150-an-orally-active-aminopeptidase-a-inhibitor-in-deoxycorticosterone-acetate-salt-rats
#12
Yannick Marc, Reda Hmazzou, Fabrice Balavoine, Adrien Flahault, Catherine Llorens-Cortes
BACKGROUND AND OBJECTIVE: Hyperactivity of the brain renin-angiotensin (Ang) system has been implicated in the development and maintenance of hypertension. AngIII, one of the main effector peptides of the brain renin-Ang system, exerts a tonic stimulatory control over blood pressure (BP) in hypertensive rats. Aminopeptidase A (APA), the enzyme generating brain AngIII, represents a new therapeutic target for the treatment of hypertension. We developed RB150, a prodrug of the specific and selective APA inhibitor, EC33...
September 28, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28957852/the-subtyping-of-primary-aldosteronism-by-adrenal-vein-sampling-sequential-blood-sampling-causes-factitious-lateralization
#13
Giacomo Rossitto, Michele Battistel, Giulio Barbiero, Valeria Bisogni, Giuseppe Maiolino, Miotto Diego, Teresa M Seccia, Gian Paolo Rossi
BACKGROUND: The pulsatile secretion of adrenocortical hormones and a stress reaction occurring when starting adrenal vein sampling (AVS) can affect the selectivity and also the assessment of lateralization when sequential blood sampling is used. We therefore tested the hypothesis that a simulated sequential blood sampling could decrease the diagnostic accuracy of lateralization index for identification of aldosterone-producing adenoma (APA), as compared with bilaterally simultaneous AVS...
September 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28957851/uric-acid-association-with-pulsatile-and-steady-components-of-central-and-peripheral-blood-pressures
#14
Fanny Lepeytre, Pierre-Luc Lavoie, Stéphan Troyanov, François Madore, Mohsen Agharazii, Rémi Goupil
OBJECTIVE: Whether the cardiovascular risk attributed to elevated uric acid levels may be explained by changes in central and peripheral pulsatile and/or steady blood pressure (BP) components remains controversial. METHODS: In a cross-sectional analysis of normotensive and untreated hypertensive participants of the CARTaGENE populational cohort, we examined the relationship between uric acid, and both pulsatile and steady components of peripheral and central BP, using sex-stratified linear regressions...
September 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28957850/objective-sleep-quality-and-night-time-blood-pressure-in-the-general-elderly-population-a-cross-sectional-study-of-the-heijo-kyo-cohort
#15
Masataka Oume, Kenji Obayashi, Yuji Asai, Moe Ogura, Katsuya Takeuchi, Yoshiaki Tai, Norio Kurumatani, Keigo Saeki
OBJECTIVES: Night-time blood pressure (BP) - prognostically more important than circadian BP variability - has not been evaluated for quantitative associations with objective sleep quality in large populations. METHODS: The cross-sectional study measured actigraphic sleep parameters and night-time BP for two nights in 1101 elderly participants. RESULTS: Mean age of the participants was 71.8 years, and mean night-time SBP and DBP were 115.9 ± 16...
September 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28957849/substandard-drugs-among-five-common-antihypertensive-generic-medications-an-analysis-from-10-african-countries
#16
Diane Macquart de Terline, Bara I Diop, Melisande Bernard, Bernard Do, Méo S Ikama, Roland N'guetta, Dadhi M Balde, Yessoufou Tchabi, Abdallahi Sidi Aly, Ibrahim Ali Toure, Patrick Zabsonre, Jean-Marc F Damorou, Jean-Laurent Takombe, Kumar Narayanan, Christine Fernandez, Muriel Tafflet, Pierre-François Plouin, Jean-Philippe Empana, Eloi Marijon, Xavier Jouven, Marie Antignac
OBJECTIVE: Hypertension results in more deaths than any other risk factor and has been on the rise in sub-Saharan Africa over the past few decades. Generic drugs have helped improve accessibility and affordability of antihypertensive therapy in developing countries. However, assessment of quality standards of these products is important. We performed a quality assessment of five commonly used antihypertensive generic drugs in 10 sub-Saharan African countries and studied the impact of price on quality...
September 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28957848/cardiovascular-outcome-in-treatment-resistant-hypertension-results-from-the-swedish-primary-care-cardiovascular-database-spccd
#17
Lina Holmqvist, Kristina B Boström, Thomas Kahan, Linus Schiöler, Jan Hasselström, Per Hjerpe, Björn Wettermark, Karin Manhem
OBJECTIVE: To assess cardiovascular outcome in patients with treatment-resistant hypertension (TRH) compared with patients with nontreatment-resistant hypertension (HTN). METHODS: Cohort study with data from 2006 to 2012 derived from the Swedish Primary Care Cardiovascular Database with hypertensive patients aged at least 30 years. TRH was defined as blood pressure at least 140/90 mmHg despite medication adherence to three or more dispensed antihypertensive drug classes...
September 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28938338/mortality-implications-of-lower-dbp-with-lower-achieved-systolic-pressures-in-coronary-artery-disease-long-term-mortality-results-from-the-international-verapamil-trandolapril-study-us-cohort
#18
Anita Wokhlu, Steven M Smith, Yan Gong, Eileen M Handberg, Islam Y Elgendy, Anthony A Bavry, Rhonda M Cooper-DeHoff, Carl J Pepine
OBJECTIVES: A goal SBP 120 mmHg or less reduced mortality in high-risk Systolic Blood Pressure Intervention Trial patients; however, mortality implications of concomitant DBP lowering in coronary artery disease (CAD) are uncertain. We examined the relationship between DBP lowering and all-cause mortality with lower achieved SBPs in a large cohort. METHODS: We categorized 17 131 hypertensive patients from the INternational VErapamil-trandolapril STudy US cohort, aged at least 50 years with CAD, by mean achieved SBP (<120, 120 to <130, 130 to <140, and ≥140 mmHg) and DBP tertiles (low, middle, and high per SBP category) during active follow-up...
September 21, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28938337/pulse-pressure-is-associated-with-plasma-amyloid-%C3%AE-transport-dysfunction
#19
Yu Jiang, Suhang Shang, Pei Li, Chen Chen, Liangjun Dang, Jin Wang, Kang Huo, Meiying Deng, Jingyi Wang, Qiumin Qu
OBJECTIVE: Increased pulse pressure (PP) has been implicated in the development and progression of Alzheimer's disease in middle-aged and elderly adults. Considering the close relationship between peripheral amyloid-β clearance and brain amyloid-β deposition, we investigated the potential association between PP and plasma amyloid-β transport function. METHODS: In this cross-sectional study, a total of 1118 participants underwent a health assessment and quantification of plasma amyloid-β and amyloid-β transporter expression...
September 21, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28938336/arterial-stiffness-induced-by-carotid-calcification-leads-to-cerebral-gliosis-mediated-by-oxidative-stress
#20
Nataliya Sadekova, M Florencia Iulita, Diane Vallerand, Gervais Muhire, Mohamed Bourmoum, Audrey Claing, Hélène Girouard
BACKGROUND: Arterial stiffness is a risk factor for cognitive decline and dementia. However, its precise effects on the brain remain unexplored. Using a mouse model of carotid stiffness, we investigated its effect on glial activation and oxidative stress. METHODS: Arterial stiffness was induced by the application of calcium chloride to the adventitial region of the right carotid. Superoxide anion production, NADPH activity and levels, as well as glial activation were examined with immunohistochemical and biochemical approaches, 2-week postcalcification...
September 21, 2017: Journal of Hypertension
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