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Journal of Hypertension

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https://www.readbyqxmd.com/read/28129247/effectiveness-of-patiromer-in-the-treatment-of-hyperkalemia-in-chronic-kidney-disease-patients-with-hypertension-on-diuretics
#1
Matthew R Weir, Martha R Mayo, Dahlia Garza, Susan A Arthur, Lance Berman, David Bushinsky, Daniel J Wilson, Murray Epstein
OBJECTIVE: Recurrent hyperkalemia frequently limits use of renin-angiotensin-aldosterone system inhibitors (RAASi) in chronic kidney disease (CKD) patients with hypertension, diabetes, and/or heart failure. Patiromer is a sodium-free, nonabsorbed potassium (K)-binding polymer approved by the US Food and Drug Administration for the treatment of hyperkalemia. This post-hoc analysis of OPAL-HK examined the effectiveness and safety of patiromer in reducing serum K in hyperkalemic CKD patients on RAASi, with hypertension, receiving diuretic therapy versus those not on diuretics...
February 15, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28169886/prehypertension-among-2-19-million-adolescents-and-future-risk-for-end-stage-renal-disease
#2
Adi Leiba, Gilad Twig, Asaf Vivante, Karl Skorecki, Eliezer Golan, Estela Derazne, Dorit Tzur, Ehud Grossman, Rita Dichtiar, Jeremy D Kark, Tamar Shohat
OBJECTIVE: Persistent hypertension in adulthood is a leading cause of end-stage renal disease (ESRD). Whether lower blood pressure (BP) values, in the range of prehypertension, are also associated with future occurrence of ESRD is unclear. Even less clear is the potential risk of early prehypertension appearing in adolescence. To address this question, we examined whether BP measurements in the prehypertensive range at age 16-19 years predict adult ESRD. METHODS: Medical data on 2194 635 16-19-year-old adolescents examined for medical fitness prior to military service from 1977 to 2013 were linked to the Israeli ESRD registry in this nationwide population-based cohort study...
February 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28169885/repetitive-exposure-to-shortened-sleep-leads-to-blunted-sleep-associated-blood-pressure-dipping
#3
Huan Yang, Monika Haack, Shiva Gautam, Hans K Meier-Ewert, Janet M Mullington
BACKGROUND: Blood pressure (BP) dips at night during sleep in healthy individuals but in disturbed sleep, dipping is blunted. However, the impact of chronic insufficient sleep duration, with limited intermittent recovery sleep, on BP dipping is not known. The objective of this study was to examine, in a controlled experimental model, the influence of chronic sleep restriction on BP patterns at night and during the day. METHOD: In a highly controlled 22-day in-hospital protocol, 45 healthy participants (age 32 ± 2 years; BMI 24 ± 1 kg/m; 22 men and 23 women) were randomly assigned to one of two conditions: repeated sleep restriction (4 h of sleep/night from 0300 to 0700 h for three nights followed by recovery sleep of 8 h, repeated four times in succession) or a sleep control group (8 h/night from 2300 to 0700 h)...
February 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28169884/mri-progression-of-cerebral-small-vessel-disease-and-cognitive-decline-in-patients-with-hypertension
#4
Renske Uiterwijk, Julie Staals, Marjolein Huijts, Peter W de Leeuw, Abraham A Kroon, Robert J van Oostenbrugge
OBJECTIVE: Hypertension is associated with cognitive deficits, probably because it is a major risk factor for the development of white matter hyperintensities (WMH), lacunes, and cerebral microbleeds, which are MRI markers of cerebral small vessel disease. Studies into associations between presence or progression of these MRI markers and cognitive decline in hypertensive patients are rare. We investigated the association of baseline presence and progression of MRI markers of cerebral small vessel disease with cognitive decline over 4 years in patients with hypertension...
February 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28169883/compensatory-functional-reorganization-may-precede-hypertension-related-brain-damage-and-cognitive-decline-a-functional-magnetic-resonance-imaging-study
#5
Patrycja Naumczyk, Agnieszka Sabisz, Marta Witkowska, Beata Graff, Krzysztof Jodzio, Dariusz Gąsecki, Edyta Szurowska, Krzysztof Narkiewicz
OBJECTIVES: Our study aimed at exploring structural and functional differences in the brain during higher cognitive processing between middle-aged hypertensive patients and controls matched for sex, age and years of education. METHODS: Two groups of 20 patients took part in MRI examinations. This article reports the results of functional MRI during a Stroop color interference task and structural evaluations based on a modified Fazekas scale. RESULTS: No intergroup differences were found in regards to the severity of white matter lesions (Mann-Whitney U test = 150...
February 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28169882/greater-visceral-abdominal-fat-is-associated-with-a-lower-probability-of-conversion-of-prehypertension-to-normotension
#6
You-Cheol Hwang, Wilfred Y Fujimoto, Steven E Kahn, Donna L Leonetti, Edward J Boyko
OBJECTIVE: Prehypertension is associated with increased risk for incident hypertension. However, little is known about how frequently prehypertension converts to normotension, and which variables predict this conversion. METHODS: We identified 186 Japanese Americans with prehypertension (110 men, 76 women) aged 34-75 years (mean age of 52.3 years) who were followed at 5 and 10 years after enrollment. Blood pressure was measured with a mercury sphygmomanometer and average blood pressure was calculated...
February 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28169881/side-effects-and-tolerability-of-combination-blood-pressure-lowering-according-to-blood-pressure-levels-an-analysis-of-the-perindopril-protection-against-recurrent-stroke-study-and-action-in-diabetes-and-vascular-disease-preterax-and-diamicron-mr-controlled
#7
Emily R Atkins, Yoichiro Hirakawa, Abdul Salam, Mark Woodward, Mark Cooper, Pavel Hamet, Stephen Harrap, Kennedy Lees, Lisheng Liu, Giuseppe Mancia, Michel Marre, Vlado Perkovic, Neil Poulter, Bryan Williams, John Chalmers, Anthony Rodgers
OBJECTIVE: To measure the placebo-controlled effects of combination therapy on hypotension, treatment discontinuation, and major renal outcomes, according to baseline blood pressure. METHODS: We conducted an analysis of the action in diabetes and vascular disease: preterax and diamicron-MR controlled evaluation and perindopril protection against recurrent stroke study trials, including 14 684 participants allocated combination therapy or placebo. The mean age was 65 years, 61% were men, and 64% were receiving background blood pressure lowering (BPL) therapy...
February 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28169880/blood-pressure-reduction-in-acute-ischemic-stroke-according-to-time-to-treatment-a-subgroup-analysis-of-the-china-antihypertensive-trial-in-acute-ischemic-stroke-trial
#8
Tan Xu, Yonghong Zhang, Xiaoqing Bu, Dali Wang, Yingxian Sun, Chung-Shiuan Chen, Jinchao Wang, Hao Peng, Zhong Ju, Yanbo Peng, Tian Xu, Qunwei Li, Deqin Geng, Jintao Zhang, Dong Li, Fengshan Zhang, Libing Guo, Xuemei Wang, Yong Cui, Yongqiu Li, Dihui Ma, Dongsheng Zhang, Guang Yang, Yanjun Gao, Xiaodong Yuan, Jing Chen, Jiang He
OBJECTIVE: The optimal time to initiate antihypertensive therapy among patients with acute ischemic stroke remains uncertain. We tested the effects of blood pressure reduction among patients with acute ischemic stroke according to time from onset to initiation of antihypertensive treatment. METHODS: We randomly assigned 4071 acute ischemic stroke patients with elevated SBP to receive antihypertensive treatment or to discontinue all antihypertensive medications during hospitalization...
February 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28157814/hypertension-in-dialysis-patients-a-consensus-document-by-the-european-renal-and-cardiovascular-medicine-eureca-m-working-group-of-the-european-renal-association-european-dialysis-and-transplant-association-era-edta-and-the-hypertension-and-the-kidney-working
#9
Pantelis A Sarafidis, Alexandre Persu, Rajiv Agarwal, Michel Burnier, Peter de Leeuw, Charles Ferro, Jean-Michel Halimi, Gunnar Heine, Michel Jadoul, Faical Jarraya, Mehmet Kanbay, Francesca Mallamaci, Patrick B Mark, Alberto Ortiz, Gianfranco Parati, Roberto Pontremoli, Patrick Rossignol, Luis Ruilope, Patricia Van der Niepen, Raymond Vanholder, Marianne C Verharr, Andrzej Wiecek, Gregoire Wuerzner, Gérard M London, Carmine Zoccali
In patients with end-stage renal disease treated with hemodialysis or peritoneal dialysis, hypertension is very common and often poorly controlled. Blood pressure (BP) recordings obtained before or after hemodialysis display a J-shaped or U-shaped association with cardiovascular events and survival, but this most likely reflects the low accuracy of these measurements and the peculiar hemodynamic setting related with dialysis treatment. Elevated BP by home or ambulatory BP monitoring is clearly associated with shorter survival...
February 2, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28157813/blood-pressure-and-kidney-cancer-risk-meta-analysis-of-prospective-studies
#10
Khemayanto Hidayat, Xuan Du, Sheng-Yi Zou, Bi-Min Shi
BACKGROUND: Globally, kidney cancer is the twelfth most common cancer, accounting for 337 860 cases recorded in 2012. By 2020, this number has been estimated to reach 412 929 or increase by 22%. Over the past few decades, a number of prospective studies have investigated the association between blood pressure (BP) and risk of kidney cancer, using either recorded BP levels or reported hypertension as the principal exposure variable. However, the relation of BP to kidney cancer remains incompletely understood, and the data on sex-specific differences in risk estimates have been inconsistent...
February 2, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28151773/high-prevalence-of-hypertension-among-iranian-children-and-adolescents-a-systematic-review-and-meta-analysis
#11
Maryam Akbari, Mahmood Moosazadeh, Sulmaz Ghahramani, Reza Tabrizi, Fariba Kolahdooz, Zatollah Asemi, Kamran B Lankarani
BACKGROUND: High blood pressure in children is a public health problem and the most important risk factor for cardiovascular disease at an older age. Several preliminary studies have been published regarding the prevalence of high blood pressure in which there was significant disparity. OBJECTIVE: This study aimed to estimate the prevalence of hypertension in Iranian children using the meta-analysis approach. METHODS: A systematic search of national and international databases was conducted through September 30, 2015, for population studies providing estimates on the prevalence of hypertension in Iranian children and adolescents...
February 1, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28141660/effects-of-blood-pressure-lowering-treatment-on-outcome-incidence-in-hypertension-10-should-blood-pressure-management-differ-in-hypertensive-patients-with-and-without-diabetes-mellitus-overview-and-meta-analyses-of-randomized-trials
#12
Costas Thomopoulos, Gianfranco Parati, Alberto Zanchetti
BACKGROUND: Type 2 diabetes mellitus is associated with an increased risk of hypertension, and cardiovascular and renal disease, and it has been recommended that management of hypertension should be more aggressive in presence than in absence of diabetes mellitus, but the matter is controversial at present. OBJECTIVES: Meta-analysing all available randomized controlled trials (RCTs) to compare the effects on cardiovascular and renal outcomes of blood pressure BP lowering to different systolic BP (SBP) and diastolic BP (DBP) levels or by different drug classes in patients with and without diabetes mellitus...
January 30, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28141659/altered-plasma-fibrin-clot-properties-in-hypertensive-patients-with-obstructive-sleep-apnoea-are-improved-by-continuous-positive-airway-pressure-treatment
#13
Katarzyna Jóźwik-Plebanek, Aleksander Prejbisz, Ewa Wypasek, Barbara Pręgowska-Chwała, Katarzyna Hanus, Anna M Kaszuba, Magdalena Januszewicz, Przemysław Bieleń, Marek Kabat, Mariusz Kruk, Piotr Dobrowolski, Anna Klisiewicz, Paweł Śliwiński, Andrzej Januszewicz, Anetta Undas
AIM: We investigated plasma fibrin clot properties in high-risk hypertensive patients with obstructive sleep apnoea (OSA) and assessed the impact of continuous positive airway pressure (CPAP) treatment on clot phenotype. METHODS: We studied 50 hypertensive patients with clinically significant OSA (age 50.0 ± 8.8 years, 39 M, 11 F). In total, 38 hypertensive patients without OSA balanced for age, sex, blood pressure, cardiovascular risk factors, and metabolic status served as controls...
January 30, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28129252/optimal-diagnostic-thresholds-for-diagnosis-of-orthostatic-hypotension-with-a-sit-to-stand-test
#14
Brett H Shaw, Emily M Garland, Bonnie K Black, Sachin Y Paranjape, Cyndya A Shibao, Luis E Okamoto, Alfredo Gamboa, André Diedrich, W Dale Plummer, William D Dupont, Italo Biaggioni, David Robertson, Satish R Raj
OBJECTIVE: This study aimed to identify optimal blood pressure cut-offs to diagnose orthostatic hypotension during a sit-to-stand manoeuvre. METHODS: This was a cross-sectional study of patients and healthy controls from the Vanderbilt Autonomic Dysfunction Center. Blood pressure was measured while supine, seated and standing. Blood pressure changes were calculated from supine-to-standing and seated-to-standing. Orthostatic hypotension was diagnosed on the basis of a supine-to-standing SBP drop at least 20 mmHg or a DBP drop at least 10 mmHg...
January 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28129251/effects-of-the-glucagon-like-peptide-1-receptor-agonist-liraglutide-on-24-h-ambulatory-blood-pressure-in-patients-with-type-2-diabetes-and-stable-coronary-artery-disease-a-randomized-double-blind-placebo-controlled-crossover-study
#15
Preman Kumarathurai, Christian Anholm, Andreas Fabricius-Bjerre, Olav W Nielsen, Ole Kristiansen, Sten Madsbad, Steen B Haugaard, Ahmad Sajadieh
OBJECTIVE: The glucagon-like peptide-1 receptor agonist liraglutide has been shown to reduce blood pressure (BP) in clinical trials using office BP measurements. However, the effects of liraglutide on 24-h BP and on the diurnal variation in BP have not been explored sufficiently. METHODS: Forty-one patients with type 2 diabetes and stable coronary artery disease were randomized to receive liraglutide or placebo to a backbone therapy of metformin in this double-blind, placebo-controlled 12 along with 12 weeks crossover study...
January 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28129250/carotid-femoral-pulse-wave-velocity-in-type-2-diabetes-and-hypertension-capturing-arterial-health-effects-of-step-counts
#16
Kaberi Dasgupta, Ellen Rosenberg, Lawrence Joseph, Luc Trudeau, Natasha Garfield, Deborah Chan, Mark Sherman, Rémi Rabasa-Lhoret, Stella S Daskalopoulou
OBJECTIVE: Optimal medication use obscures the impact of physical activity on traditional cardiometabolic risk factors. We evaluated the relationship between step counts and carotid-femoral pulse wave velocity (cfPWV), a summative risk indicator, in patients with type 2 diabetes and/or hypertension. RESEARCH DESIGN AND METHODS: Three hundred and sixty-nine participants were recruited (outpatient clinics; Montreal, Quebec; 2011-2015). Physical activity (pedometer/accelerometer), cfPWV (applanation tonometry), and risk factors (A1C, Homeostatic Model Assessment-Insulin Resistance, blood pressure, lipid profiles) were evaluated...
January 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28129249/correlation-of-carotid-artery-reactivity-with-cardiovascular-risk-factors-and-coronary-artery-vasodilator-responses-in-asymptomatic-healthy-volunteers
#17
Anke C C M van Mil, Yvonne Hartman, Frederieke van Oorschot, Annemieke Heemels, Nikki Bax, Ellen A Dawson, Nicola Hopkins, Maria T E Hopman, Daniel J Green, David L Oxborough, Dick H J Thijssen
OBJECTIVES: Carotid artery reactivity (CAR%), involving carotid artery diameter responses to a cold pressor test (CPT), is a noninvasive measure of conduit artery function in humans. This study examined the impact of age and cardiovascular risk factors on the CAR% and the relationship between CAR% and coronary artery vasodilator responses to the CPT. METHODS: Ultrasound was used to measure resting and peak carotid artery diameters during the CPT, with CAR% being calculated as the relative change from baseline (%)...
January 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28129248/efficacy-of-aspirin-and-statins-in-primary-prevention-of-cardiovascular-mortality-in-uncomplicated-hypertensive-participants-a-korean-national-cohort-study
#18
Chan Joo Lee, Jaewon Oh, Sang-Hak Lee, Seok-Min Kang, Donghoon Choi, Hyeon-Chang Kim, Sungha Park
INTRODUCTION: To determine whether the addition of aspirin to a statin regimen is beneficial in reducing cardiovascular mortality, we analyzed data for uncomplicated hypertensive patients included in the Korea National Health Insurance sample cohort. METHOD: Among the 758 433 eligible participants aged 20 years or older in 2005, 31 115 participants were selected and divided into four groups: no-treatment group (N = 19 628); aspirin alone group (N = 4814); statins alone group (N = 4717); and combined treatment group (N = 1956)...
January 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28129246/effects-of-continuous-positive-airway-pressure-treatment-on-aldosterone-excretion-in-patients-with-obstructive-sleep-apnoea-and-resistant-hypertension-a-randomized-controlled-trial
#19
Fabio de Souza, Elizabeth S Muxfeldt, Victor Margallo, Arthur F Cortez, Aline H Cavalcanti, Gil F Salles
OBJECTIVE: Aldosterone excess has been equally associated with resistant hypertension (RHT) and obstructive sleep apnoea (OSA). We conducted a randomized controlled study to assess the effect of continuous positive airway pressure (CPAP) treatment on 24-h urinary aldosterone excretion in patients with RHT and moderate/severe OSA. METHODS: A total of 117 patients were randomized (57 CPAP and 60 control groups). Aldosterone excretion was determined by 24 h urine (24h-UAldo) collected at randomization and after 6 months of follow-up...
January 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28129245/plasma-aldosterone-level-within-the-normal-range-is-less-associated-with-cardiovascular-and-cerebrovascular-risk-in-primary-aldosteronism
#20
Masahiko Murata, Tetsuhiro Kitamura, Daisuke Tamada, Kosuke Mukai, Shogo Kurebayashi, Tsunehiko Yamamoto, Kunihiko Hashimoto, Reiko D Hayashi, Haruhiko Kouhara, Sachi Takeiri, Yoshitaka Kajimoto, Makoto Nakao, Toshimitsu Hamasaki, Michio Otsuki, Iichiro Shimomura
BACKGROUND: Previous studies showed higher risk of cardiovascular and cerebrovascular (CCV) events in primary aldosteronism compared with essential hypertension, but the patients of these studies were limited to primary aldosteronism patients with high plasma aldosterone concentration (PAC). The introduction of the aldosterone-renin ratio as the screening test for primary aldosteronism led to the recognition of primary aldosteronism patients with normal PAC (nPA). However, there is no information on the risk of primary aldosteronism including nPA...
January 27, 2017: Journal of Hypertension
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