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Journal of Hypertension

Hongwei Ji, Jiadela Teliewubai, Yuyan Lu, Jing Xiong, Shikai Yu, Chen Chi, Jue Li, Jacques Blacher, Yi Zhang, Yawei Xu
OBJECTIVES: Vascular aging represents a mediating step between risk factors and cardiovascular events, and preclinical target organ damage (TOD) integrates the cumulative effect of cardiovascular risk factors. This study is aimed at the relationships between vascular aging and TOD. METHODS: Two thousand and ninety-eight participants (45.52% men, aged 71.3 ± 6.1 years) were recruited from June 2014 to June 2017 from the communities in the northern Shanghai area...
January 31, 2018: Journal of Hypertension
Saiful A Mir, Ying Li, Jacob D Story, Soma Bal, Linda Awdishu, Anneke A Street, Ravindra L Mehta, Prabhleen Singh, Sucheta M Vaingankar
OBJECTIVE: Elevated circulating chromogranin A (CHGA) is observed in human hypertension. CHGA is critical for granulogenesis and exocytosis of catecholamine stores from secretory large dense core vesicles (LDCV). This study aims to understand the morphological, molecular and phenotypic changes because of excess CHGA and the mechanistic link eventuating in hyper-adrenergic hypertension. METHODS: Blood pressure and heart rate was monitored in mouse models expressing normal and elevated level of CHGA by telemetry...
January 31, 2018: Journal of Hypertension
William J He, Chongke Zhong, Tan Xu, Dali Wang, Yingxian Sun, Xiaoqing Bu, Chung-Shiuan Chen, Jinchao Wang, Zhong Ju, Qunwei Li, Jintao Zhang, Deqin Geng, Jianhui Zhang, Dong Li, Yongqiu Li, Xiaodong Yuan, Yonghong Zhang, Tanika N Kelly
BACKGROUND: We studied the effect of early antihypertensive treatment on death, major disability, and vascular events among patients with acute ischemic stroke according to their baseline SBP. METHODS: We randomly assigned 4071 acute ischemic stroke patients with SBP between 140 and less than 220 mmHg to receive antihypertensive treatment or to discontinue all antihypertensive medications during hospitalization. A composite primary outcome of death and major disability and secondary outcomes were compared between treatment and control stratified by baseline SBP levels of less than 160, 160-179, and at least 180 mmHg...
January 31, 2018: Journal of Hypertension
Jessica C Foster-Dingley, Justine E F Moonen, Wouter de Ruijter, Roos C van der Mast, Jeroen van der Grond
OBJECTIVE: Particularly in old age, orthostatic hypotension has been related to worse cognitive functioning, possibly caused by reduced cerebral blood flow (CBF). This study investigates whether orthostatic hypotension in older people is associated with cognitive dysfunction and, if so, whether this association is mediated by cerebral vascular damage and/or decreased CBF. METHODS: Four hundred and twenty participants of the Discontinuation of ANtihypertensive Treatment in Elderly People (DANTE) Study Leiden (mean age 81 years, all using antihypertensive medication and with mild cognitive deficits), and MRI data from 214 participants of the nested DANTE MRI sub-study...
January 25, 2018: Journal of Hypertension
Remy J H Martens, Alfons J H M Houben, Jeroen P Kooman, Tos T J M Berendschot, Pieter C Dagnelie, Carla J H van der Kallen, Abraham A Kroon, Karel M L Leunissen, Frank M van der Sande, Nicolaas C Schaper, Jan S A G Schouten, Miranda T Schram, Simone J S Sep, Ben M Sörensen, Ronald M A Henry, Coen D A Stehouwer
OBJECTIVE: Albuminuria is thought to be a biomarker of microvascular and macrovascular endothelial dysfunction. However, direct evidence for an association of microvascular endothelial dysfunction with albuminuria is limited. In addition, experimental data suggest a stronger association of microvascular endothelial dysfunction with albuminuria in individuals with than in those without diabetes. METHODS: We examined cross-sectional associations of flicker light-induced retinal arteriolar dilation (n = 2095) and heat-induced skin hyperemia (n = 1508) with 24-h albuminuria in the population-based, diabetes-enriched Maastricht Study...
January 25, 2018: Journal of Hypertension
Giada Zurlo, Jérôme Piquereau, Maryline Moulin, Julie Pires Da Silva, Mélanie Gressette, Benoît Ranchoux, Anne Garnier, Renée Ventura-Clapier, Elie Fadel, Marc Humbert, Christophe Lemaire, Frédéric Perros, Vladimir Veksler
OBJECTIVE: Energy metabolism shift from oxidative phosphorylation toward glycolysis in pulmonary artery smooth muscle cells (PASMCs) is suggested to be involved in their hyperproliferation in pulmonary arterial hypertension (PAH). Here, we studied the role of the deacetylase sirtuin1 (SIRT1) in energy metabolism regulation in PASMCs via various pathways including activation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), master regulator of mitochondrial biogenesis...
January 24, 2018: Journal of Hypertension
Alberto Zanchetti
No abstract text is available yet for this article.
January 23, 2018: Journal of Hypertension
Kazuo Eguchi, Satoshi Hoshide, Kazuomi Kario
BACKGROUND: It is not established to what extent self-monitoring of home BP be lowered in patients with type 2 diabetes. We tested the hypothesis that the appropriate home morning SBP cutoff value is 125 mmHg in our stratification of cardiovascular risk in type 2 diabetes. METHOD: Clinic and home BP monitoring were performed in 4308 individuals (1057 people with diabetes and 3251, nondiabetes), and we tested two cutoff values of home morning SBP (MSBP): 135 and 125 mmHg...
January 23, 2018: Journal of Hypertension
Kristina Beijer, Erik Lampa, Johan Sundström, Peter M Nilsson, Sölve Elmståhl, Nancy L Pedersen, Lars Lind
OBJECTIVES: The aim was to investigate if there is an interaction between sitting time and leisure time physical activity on blood pressure and if there are age differences and sex differences in this respect. METHODS: Linear regression analysis on cross-sectional data was performed in more than 45 000 men and women from two Swedish cohort studies, EpiHealth (45-75 years) and LifeGene (18-45 years). Self-reported leisure time physical activity was given in five levels from low (level 1) to vigorous physical activity (level 5) and television time was used as a proxy measure of sitting time...
January 23, 2018: Journal of Hypertension
Alon Botzer, Ehud Grossman, John Moult, Ron Unger
OBJECTIVES: The goal of this study was to investigate genes associated with essential hypertension from a system perspective, making use of bioinformatic tools to gain insights that are not evident when focusing at a detail-based resolution. METHODS: Using various databases (pathways, Genome Wide Association Studies, knockouts etc.), we compiled a set of about 200 genes that play a major role in hypertension and identified the interactions between them. This enabled us to create a protein-protein interaction network graph, from which we identified key elements, based on graph centrality analysis...
January 23, 2018: Journal of Hypertension
Teemu J Niiranen, Honghuang Lin, Martin G Larson, Ramachandran S Vasan
OBJECTIVES: Prior studies suggest that hypertensive target organ damage (TOD) is a heritable trait. However, the risk that parental TOD confers on propensity for TOD in their offspring, and how hypertensive TOD clusters in the context of parental versus offspring hypertension status remain unclear. METHODS: We studied 3238 Framingham Heart Study participants (mean age 39 ± 8 years, 53% women) with available parental data on TOD. Parents and offspring underwent measurements for left ventricular hypertrophy, increased relative wall thickness, albuminuria and conventional risk factors...
January 23, 2018: Journal of Hypertension
Enrique Martín-Rioboó, Luis A Pérula de Torres, José R Banegas, José M Lobos-Bejarano, Carlos Brotons Cuixart, Emilio I García Criado, Pilar Martin-Carrillo, María Martín-Rabadán Muro, M Isabel Egocheaga Cabello, Antoni Maiques Galán
OBJECTIVE: To examine the degree of knowledge and management of automated devices for office blood pressure measurement (AD), home blood pressure monitoring (HBPM) and ambulatory blood pressure monitoring (ABPM) in primary care in Spain. METHODS: Online self-administered survey sent between May 2016 and February 2017 to 2221 primary-care physicians working across Spain. Clinicians were mostly identified through national primary-care scientific societies (20% overall response rate)...
January 19, 2018: Journal of Hypertension
George Bazoukis, Costas Thomopoulos, Costas Tsioufis
OBJECTIVES: Although mineralocorticoid antagonists (MRAs) have been proposed as effective fourth-line blood pressure (BP)-lowering agents in resistant hypertension, this effect in hypertension at-large is unclear. We evaluated whether MRAs-mediated BP lowering is both effective and safe against controls and whether the extent of BP lowering differs between resistant hypertension and nonresistant hypertension . METHODS: We searched Medline and the Cochrane Collaboration Library databases from 1991 to mid-September 2017 for randomized controlled trials (RCTs), in which MRAs were compared with placebo or other active drugs...
January 19, 2018: Journal of Hypertension
William C Cushman, George L Bakris, William B White, Michael A Weber, Domenic Sica, Andrew Roberts, Eric Lloyd, Stuart Kupfer
BACKGROUND: Azilsartan medoxomil (AZL-M), an angiotensin II receptor blocker, has been developed in fixed-dose combinations (FDCs) with chlorthalidone (CTD). OBJECTIVE/METHODS: We compared FDCs of AZL-M/CTD 20/12.5 mg once daily titrated to 40/25 mg if needed or AZL-M/CTD 40/12.5 mg once daily titrated to 80/25 mg if needed with an olmesartan medoxomil (OLM)-hydrochlorothiazide (HCTZ) 20/12.5 mg FDC once daily titrated to 40/25 mg if needed in a randomized, double-blind, 8-week study of 1085 participants with clinic SBP 160-190 mmHg and DBP 119 mmHg or less...
January 13, 2018: Journal of Hypertension
Thiago Quinaglia, Mourad Z Bensalah, Emilie Bollache, Nadjia Kachenoura, Gilles Soulat, Pierre Boutouyrie, Stéphane Laurent, Elie Mousseaux
BACKGROUND: Left ventricular (LV) remodeling and aortic stiffness have independent predictive value for all causes and cardiovascular mortality. Because elastic properties of the arterial wall vary along the aortic pathway, we hypothesized that local and regional aortic stiffness could differently impact on LV remodeling. METHODS AND RESULTS: Regional aortic stiffness was determined from carotid-femoral pulse wave velocity (cfPWV) measured by aplanation tonometry...
January 13, 2018: Journal of Hypertension
Mohamed Waseem Osman, Mintu Nath, Eamonn Breslin, Asma Khalil, David R Webb, Thompson G Robinson, Hatem A Mousa
OBJECTIVE: We present a comprehensive systematic review of published literature to examine, whether arterial stiffness and wave reflection measurements during pregnancy differed between healthy patients and patients with placental-mediated diseases including preeclampsia (PET), small for gestational age (SGA), fetal death, and placental abruption, and a quantitative assessment of the findings using the meta-analysis approach. METHODS: We searched Medline, Embase, and The Cochrane Library for studies of arterial stiffness in pregnancy, analyzed pregnancy outcomes and conducted the meta-analysis of data evaluated by trimesters of pregnancy...
January 13, 2018: Journal of Hypertension
Jirar Topouchian, Carlos Labat, Sylvie Gautier, Magnus Bäck, Apostolos Achimastos, Jacques Blacher, Marcin Cwynar, Alejandro de la Sierra, Denes Pall, Francesco Fantin, Katalin Farkas, Luis Garcia-Ortiz, Zoya Hakobyan, Piotr Jankowski, Ana Jelakovic, Zhanna Kobalava, Alexandra Konradi, Yulia Kotovskaya, Marina Kotsani, Irina Lazareva, Alexander Litvin, Viktor Milyagin, Iveta Mintale, Oscar Persson, Rafael Ramos, Anatoly Rogoza, Ligita Ryliskyte, Angelo Scuteri, Yuriy Sirenko, Georges Soulis, Nebojsa Tasic, Maryna Udovychenko, Saule Urazalina, Peter Wohlfahrt, Parounak Zelveian, Athanase Benetos, Roland Asmar
OBJECTIVE: The aim of the Advanced Approach to Arterial Stiffness study was to compare arterial stiffness measured simultaneously with two different methods in different age groups of middle-aged and older adults with or without metabolic syndrome (MetS). The specific effects of the different MetS components on arterial stiffness were also studied. METHODS: This prospective, multicentre, international study included 2224 patients aged 40 years and older, 1664 with and 560 without MetS...
January 10, 2018: Journal of Hypertension
Niels Henrik Buus, Rasmus K Carlsen, Dinah S Khatir, Hans Eiskjær, Michael J Mulvany, Karin Skov
AIM: Established essential hypertension is associated with increased arterial stiffness and peripheral resistance, but the extent of vascular changes in persons genetically predisposed for essential hypertension is uncertain. METHODS: Participants from the Danish Hypertension Prevention Project (DHyPP) (both parents hypertensive) (n = 95, 41 ± 1 years, 53% men) were compared with available spouses (n = 45, 41 ± 1 years) using measurements of ambulatory blood pressure (BP), left ventricular mass index (LVMI), pulse wave velocity, central BP and augmentation index (AIx) in addition to forearm resting and minimal resistance [forearm resting vascular resistance (Rrest) and forearm minimal vascular resistance (Rmin)]...
January 4, 2018: Journal of Hypertension
Li Ling, Dan Chen, Ying Tong, Ying-Hao Zang, Xing-Sheng Ren, Hong Zhou, Xiao-Hong Qi, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
OBJECTIVE: Phenotypic transformation of adventitial fibroblasts is important in the pathogenesis of hypertension. This study was designed to determine whether fibronectin type III domain containing 5 (FNDC5) alleviates the phenotypic transformation of adventitial fibroblasts in hypertension and the underlying mechanisms. METHODS AND RESULTS: Experiments were carried out in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) and primary aortic adventitial fibroblasts...
January 4, 2018: Journal of Hypertension
Thérèse Deborde, Laurence Amar, Guillaume Bobrie, Nicolas Postel-Vinay, Christiane Battaglia, Amokrane Tache, Antoine Chedid, Mohamed-Malek Dhib, Gilles Chatellier, Pierre-François Plouin, Anita Burgun, Michel Azizi, Anne-Sophie Jannot
BACKGROUND: Sex differences in antihypertensive treatment have often been highlighted, but whether there is truly a difference or whether this difference is mediated by confounding factors has yet to be deciphered. PATIENTS AND METHODS: We performed a cross-sectional study on the first consultation in the Georges Pompidou Hospital Tertiary Hypertension Unit between July 2000 and June 2015 to explore sex differences in both patient and treatment characteristics over this period...
January 4, 2018: Journal of Hypertension
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