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Journal of Hypertension

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https://www.readbyqxmd.com/read/28614093/central-diastolic-pressure-decay-mediates-the-relationship-between-aortic-stiffness-and-myocardial-viability-potential-implications-for-aortosclerosis-induced-myocardial-ischemia
#1
Junichiro Hashimoto, Sadayoshi Ito
OBJECTIVE: Stiffening of the aorta often precedes coronary events, but little is known about the aetiological mechanism. We hypothesized that the predisposition to myocardial ischemia could be attributable to aortosclerosis-induced alterations in the central haemodynamics during diastole. METHODS: Using noninvasive tonometry and ultrasonography, we investigated the arterial pressure pulse waveforms, pulse wave velocities (PWVs) and compliance in 222 patients with hypertension...
June 16, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28622156/aerobic-versus-isometric-handgrip-exercise-in-hypertension-a-randomized-controlled-trial
#2
Nikolaos Pagonas, Stergios Vlatsas, Frederic Bauer, Felix S Seibert, Walter Zidek, Nina Babel, Peter Schlattmann, Timm H Westhoff
OBJECTIVES: Aerobic dynamic exercise reduces blood pressure (BP) and is broadly recommended by current American and European hypertension guidelines. Isometric exercise is currently not recommended, since data from only a few studies are available. We compare for the first time the effects of isometric handgrip training and aerobic exercise in a randomized controlled trial. METHODS: A total of 75 hypertensive patients were randomized to one of the following 12-week programmes: Isometric handgrip training five times weekly (two contractions of 2 min at 30% of maximal power with each arm); 'Sham-handgrip training' five times weekly (two contractions of 2 min at 5% of maximal power with each arm); Aerobic exercise training of 30 min three to five times per week...
June 15, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28622157/predictors-of-5-year-outcomes-in-malignant-phase-hypertension-the-west-birmingham-malignant-hypertension-registry
#3
Alena Shantsila, Eduard Shantsila, D Gareth Beevers, Gregory Y H Lip
OBJECTIVE: Malignant hypertension represents a high-risk condition and there are scarce data on current clinical patterns of this condition. The aim of the study is to identify the clinical and demographic factors associated with poor outcome. METHODS: The data collected from 1958 to May 2016 included a total of 351 patients whose 5-year survival status was known: 221 white Caucasians (63%, age 51 ± 13 years, 64% male), 83 African-Caribbeans (24%, 45 ± 11 years, 61% male), and 47 South Asians (13%, 42 ± 11 years, 74% male)...
June 14, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28614094/plasma-renin-activity-to-plasma-aldosterone-concentration-ratio-correlates-with-night-time-and-pulse-pressures-in-essential-hypertensive-patients-treated-with-angiotensin-converting-enzyme-inhibitors-at1-blockers
#4
Francesco Spannella, Federico Giulietti, Paolo Balietti, Elisabetta Borioni, Francesca E Lombardi, Maddalena Ricci, Guido Cocci, Laura Landi, Riccardo Sarzani
OBJECTIVES: Angiotensin-converting enzyme inhibitors (ACE-I) and AT1 blockers (ARB) are commonly used antihypertensive drugs, but several factors may affect their effectiveness. We evaluated the associations between ambulatory blood pressure (BP) monitoring (ABPM) parameters and plasma renin activity (PRA)-to-plasma aldosterone concentration (PAC) ratio (RAR) to test renin-angiotensin-aldosterone system inhibition in essential hypertensive patients treated with ACE-I or ARB for at least 12 months...
June 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28598954/role-of-the-sympathetic-nervous-system-in-regulation-of-the-sodium-glucose-cotransporter-2
#5
Vance B Matthews, Rosemary H Elliot, Caroline Rudnicka, Jana Hricova, Lakshini Herat, Markus P Schlaich
BACKGROUND: The sympathetic nervous system (SNS) regulates glucose metabolism in various organs including the kidneys. The sodium glucose cotransporter 2 (SGLT2) mediates glucose reabsorption in renal proximal tubules and its inhibition has been shown to improve glucose control, cardiovascular and renal outcomes. We hypothesized that SNS-induced alterations of glucose metabolism may be mediated via regulation of SGLT2. METHOD: We used human renal proximal tubule cells to investigate the effects of noradrenaline on SGLT2 regulation...
June 8, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28598953/uromodulin-associates-with-cardiorenal-function-in-patients-with-hypertension-and-cardiovascular-disease
#6
Engi A H Algharably, Juliane Bolbrinker, Susanne Lezius, Rona Reibis, Karl Wegscheider, Heinz Völler, Reinhold Kreutz
OBJECTIVE: Common genetic variants in the gene encoding uromodulin (UMOD) have been associated with renal function, blood pressure (BP) and hypertension. We investigated the associations between an important single nucleotide polymorphism (SNP) in UMOD, that is rs12917707-G>T, and estimated glomerular filtration rate (eGFR), BP and cardiac organ damage as determined by echocardiography in patients with arterial hypertension. METHODS: A cohort of 1218 treated high-risk patients (mean age 58...
June 8, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28594711/effects-of-repeated-yearly-exposure-to-exercise-training-on-blood-pressure-and-metabolic-syndrome-evolution
#7
Felix Morales-Palomo, Miguel Ramirez-Jimenez, Juan F Ortega, Pedro L Lopez-Galindo, Juan Fernandez-Martin, Ricardo Mora-Rodriguez
OBJECTIVE: To study if repeated yearly training programs consolidate the transient blood pressure (BP) improvements of one exercise program into durable adaptations. METHODS: Obese middle-age individuals with metabolic syndrome (MetS) underwent high-intensity aerobic interval training during 16 weeks (November to mid-March) in 3 consecutive years [training group (TRAIN); N = 23]. Evolution of MetS components was compared with a matched-group that remained sedentary [control group (CONT); N = 26]...
June 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28594710/twenty-four-hour-central-blood-pressure-is-not-better-associated-with-hypertensive-target-organ-damage-than-24-h-peripheral-blood-pressure
#8
Alejandro de la Sierra, Julia Pareja, Patricia Fernández-Llama, Pedro Armario, Sergi Yun, Eva Acosta, Francesca Calero, Susana Vázquez, Pedro Blanch, Cristina Sierra, Anna Oliveras
BACKGROUND AND AIM: Central blood pressure (BP) is increasingly considered as a better estimator of hypertension associated risks. We aimed to evaluate the association of 24-h central BP, in comparison with 24-h peripheral BP, with the presence of target organ damage (TOD). METHODS: Cross-sectional study of 208 hypertensive patients, aged 57 ± 12 years, 34% women. Office (mean of 4 measurements) and 24-h central and peripheral BP were measured by the oscillometric Mobil-O-Graph device...
June 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28594709/effect-of-oxidative-stress-on-racial-differences-in-vascular-function-at-rest-and-during-hand-grip-exercise
#9
Rebecca M Kappus, Kanokwan Bunsawat, Michael D Brown, Shane A Phillips, Jacob M Haus, Tracy Baynard, Bo Fernhall
OBJECTIVES: African-Americans have a higher prevalence of hypertension compared with whites, possibly due to elevated oxidative stress and subsequent vascular dysfunction. It is unclear the contribution of aging on oxidative stress and vascular function in a racially diverse cohort. METHODS: Ninety-three young and older African-American and white participants received antioxidant (AOX) or placebo supplementation in a double-blind, randomized, cross-over design. Measures of endothelial function (reactive hyperemia, flow-mediated dilation), exercise blood flow, and biomarkers of oxidative stress and AOX activity were measured following supplementation...
June 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28594708/reference-values-of-cardio-ankle-vascular-index-in-a-random-sample-of-a-white-population
#10
Peter Wohlfahrt, Renata Cífková, Narine Movsisyan, Šárka Kunzová, Jiří Lešovský, Martin Homolka, Vladimír Soška, Petr Dobšák, Francisco Lopez-Jimenez, Ondřej Sochor
OBJECTIVES: Cardio-ankle vascular index (CAVI), a parameter of arterial stiffness, has been increasingly used for cardiovascular risk estimation. Currently used CAVI reference values are derived from the Japanese population. It is not clear whether the same reference values can be used in the white population. The aim of the present study was to describe cardiovascular risk factors influencing CAVI and to establish CAVI reference values. METHODS: A total of 2160 individuals randomly selected from the Brno city population aged 25-65 years were examined...
June 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28594707/a-comparison-of-blood-pressure-in-community-pharmacies-with-ambulatory-home-and-general-practitioner-office-readings-systematic-review-and-meta-analysis
#11
Ali Albasri, Jack W OʼSullivan, Nia W Roberts, Suman Prinjha, Richard J McManus, James P Sheppard
BACKGROUND: Blood pressure (BP) readings are traditionally taken in a clinic setting, with treatment recommendations based on these measurements. The clinical interpretation of BP readings taken in community pharmacies is currently unclear. This study aimed to systematically review all literature comparing community pharmacy BP (CPBP) readings with ambulatory BP monitoring (ABPM), home BP monitoring and general practitioner clinic readings. METHOD: Studies were included if they compared CPBP with at least one other measurement modality used for the diagnosis or management of hypertension...
June 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28594706/diagnosis-of-tuberous-sclerosis-complex-in-a-patient-referred-for-uncontrolled-hypertension-and-renal-dysfunction-a-case-highlighting-the-importance-of-proper-diagnostic-work-up-of-hypertensive-patients
#12
Pantelis A Sarafidis, Athanasios Bikos, Charalampos Loutradis, Stergios Tzikas, Efstratios Vakirlis, Eugenia Avdelidou, Dimitrios Zafeiriou, Aikaterini Papagianni, Vasileios Vassilikos
: We report a case of a 39-year-old woman with resistant hypertension and renal dysfunction. The patient was hospitalized 3 months earlier for dyspnea at the Department of Cardiology, where she was diagnosed with heart failure (left ventricle injection fraction: 25-30%), pulmonary hypertension, chronic kidney disease (serum creatinine: 1.58 mg/dl), and resistant hypertension and discharged with optimal heart failure treatment. At presentation to our clinic, apart from uncontrolled hypertension for more than 10 years and history of pre-eclampsia and fetal loss, the patient had obesity (BMI: 38 kg/m) and facial fibromas...
June 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28590266/sex-differences-in-aortic-augmentation-index-in-adolescents
#13
Jennifer Y Barraclough, Frances L Garden, Brett Toelle, Shamus O'Meagher, Guy B Marks, Christopher T Cowell, David S Celermajer, Julian G Ayer
BACKGROUND: Augmentation index (AIx) is a noninvasive measure of pulse wave reflection. AIx is associated with cardiovascular disease. Adult women have a higher AIx than men, but the factors determining this sex-related difference remain to be determined. METHODS: To examine factors associated with AIx in adolescents, participants in the Childhood Asthma Prevention Study, followed from birth, were assessed at age 14 years, with AIx standardized to a heart rate of 75/min (AIx_75) and pulse wave velocity...
June 5, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28582281/relation-between-secondhand-smoke-exposure-and-cardiovascular-risk-factors-in-never-smokers
#14
Sehun Kim, Si-Hyuck Kang, Donghoon Han, Sun-Hwa Kim, Hee-Jun Kim, Jin-Joo Park, Youngjin Cho, Yeonyee E Yoon, Kyung-Do Han, Il-Young Oh, Chang-Hwan Yoon, Jung-Won Suh, Hae-Young Lee, Young-Seok Cho, Tae-Jin Youn, Goo-Yeong Cho, In-Ho Chae, Dong-Ju Choi, Cheol-Ho Kim
OBJECTIVE: Secondhand smoke exposure (SHSE) in nonsmokers has been associated with premature cardiovascular mortality and ischemic heart disease. We conducted a cross-sectional, population-based study evaluating the relationship between SHSE, measured by subjective and objective methods, and conventional cardiovascular risks such as blood pressure, lipid profiles, and fasting glucose. METHODS: We extracted information on 7376 healthy adults who had never smoked, for whom there were available urine cotinine levels, from the Korea National Health and Nutrition Examination Survey 2008-2011...
June 5, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28582285/guidelines-position-studies-and-blood-vessel-research
#15
Alberto Zanchetti
No abstract text is available yet for this article.
June 2, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28582284/favourable-impact-of-statin-use-on-diastolic-blood-pressure-levels-analysis-of-a-large-database-of-24-hour-ambulatory-blood-pressure-monitoring
#16
Giuliano Tocci, Vivianne Presta, Barbara Citoni, Ilaria Figliuzzi, Roberta Coluccia, Allegra Battistoni, M Beatrice Musumeci, Luciano De Biase, Andrea Ferrucci, Massimo Volpe
INTRODUCTION: Assumption of lipid-lowering drugs, mostly statins, is recommended at bed-time and evidence demonstrated a strong and independent correlation between night-time blood pressure (BP) and increased risk of cardiovascular events. AIM: To evaluate the effects of statins on night-time BP levels. METHODS: We analysed data derived from a large cohort of adult individuals, who consecutively underwent home, clinic and ambulatory BP monitoring at our Unit...
June 2, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28582283/reservoir-pressure-analysis-of-aortic-blood-pressure-an-in-vivo-study-at-five-locations-in-humans
#17
Om Narayan, Kim H Parker, Justin E Davies, Alun D Hughes, Ian T Meredith, James D Cameron
INTRODUCTION: The development and propagation of the aortic blood pressure wave remains poorly understood, despite its clear relevance to major organ blood flow and potential association with cardiovascular outcomes. The reservoir pressure model provides a unified description of the dual conduit and reservoir functions of the aorta. Reservoir waveform analysis resolves the aortic pressure waveform into an excess (wave related) and reservoir (compliance related) pressure. The applicability of this model to the pressure waveform as it propagates along the aorta has not been investigated in humans...
June 2, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28582282/improved-treatment-and-control-of-hypertension-in-swedish-primary-care-results-from-the-swedish-primary-care-cardiovascular-database
#18
Charlotte Holmquist, Jan Hasselström, Kristina Bengtsson Boström, Karin Manhem, Björn Wettermark, Per Hjerpe, Thomas Kahan
OBJECTIVE: To study temporal trends in hypertension treatment and control in Swedish primary care, in relation to clinical characteristics, comorbidity, and drug treatment. MATERIALS AND METHODS: Repeated cross-sectional analysis of 43 239 hypertensive patients attending primary care in 2001-2002 and of 62 407 patients in 2007-2008. RESULTS: Mean blood pressure (BP) 2007-2008 was 143/79 mmHg in women and 142/81 mmHg in men. Cardiovascular comorbidity and diabetes were present in 13 and 15% of women, and in 18 and 20% of men...
June 2, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28562422/serum-calcification-propensity-is-associated-with-renal-tissue-oxygenation-and-resistive-index-in-patients-with-arterial-hypertension-or-chronic-kidney-disease
#19
Menno Pruijm, Yimin Lu, Fatma Megdiche, Maciej Piskunowicz, Bastien Milani, Matthias Stuber, Matthias Bachtler, Bruno Vogt, Michel Burnier, Andreas Pasch
BACKGROUND: Arterial calcifications increase arterial stiffness and are associated with a faster decline of kidney function in patients with arterial hypertension (AH) and/or chronic kidney disease (CKD). Yet the underlying mechanisms linking arterial calcifications, vascular stiffness and renal function decline are incompletely understood. A novel in-vitro blood test evaluates the propensity of patient's serum to prevent the formation of calcifications by measuring the maturation time of calciprotein particles (CPP) [transformation time of amorphous calcium phosphate-containing primary CPP to crystalline hydroxyapatite-containing secondary CPP (T50)]...
May 29, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28525406/blood-pressure-among-australian-aboriginal-children
#20
Nicholas Larkins, Armando Teixeira-Pinto, Emily Banks, Hasantha Gunasekera, Alan Cass, Jane Kearnes, Jonathan C Craig
OBJECTIVES: To determine the prevalence of elevated blood pressure (BP) and potential predictors of SBP and DBP in urban Australian aboriginal children. METHODS: The Study of Environment on Aboriginal Resilience and Child Health is a prospective cohort study of urban Aboriginal children attending four Aboriginal Community Controlled Health Services in New South Wales, Australia. Clinical measures included a manual BP measured by research officers using standardized protocols...
May 18, 2017: Journal of Hypertension
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