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Journal of Hypertension

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https://www.readbyqxmd.com/read/28731931/renal-function-and-its-association-with-blood-pressure-in-middle-eastern-immigrants-and-native-swedes
#1
Christopher Nilsson, Anders Christensson, Peter M Nilsson, Louise Bennet
BACKGROUND: Iraqi-born immigrants residing in Sweden are at high risk for type 2 diabetes, obesity and hyperlipidemia compared with native Swedes. Paradoxically, hypertension is less prevalent in this immigrant population. The aim of this study was to investigate differences in renal function and further if differences in blood pressure (BP) levels were associated with differences across ethnicities in renal function as a possible explanation to the paradox. METHODS: A population-based, cross-sectional study of men and women, born in Iraq or Sweden, aged 30-75 years was conducted in Malmö, Sweden, from 2010 to 2012...
July 20, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28731930/early-life-exposure-to-chinese-famine-modifies-the-association-between-hypertension-and-cardiovascular-disease
#2
Zumin Shi, Stephen J Nicholls, Anne W Taylor, Dianna J Magliano, Sarah Appleton, Paul Zimmet
OBJECTIVE: Studies have shown that famine exposure during early life may increase the risk of cardiovascular disease (CVD), hypertension, and diabetes during adulthood. We aimed to assess whether exposure to the Chinese famine (1959-1961) modifies the association between hypertension and CVD. METHODS: We investigated data of 5772 adults born between 1954 and 1964 from the China Health and Retirement Longitudinal Study. CVD was based on self-reported doctor's diagnosis of heart problems (heart attack, coronary heart disease, angina, congestive heart failure, or other heart problems) and stroke...
July 20, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28731929/impact-of-aortic-rather-than-brachial-pulsatile-haemodynamics-on-variations-in-end-organ-measures-across-the-full-adult-blood-pressure-range
#3
Bryan Hodson, Gavin R Norton, Imraan Ballim, Carlos D Libhaber, Pinhas Sareli, Angela J Woodiwiss
AIMS: To determine the extent to which the adverse effects of blood pressure (BP) are mediated by pulsatile haemodynamic changes across the normotensive as compared with the hypertensive adult brachial BP range, and whether aortic rather than brachial pulsatile changes best index these effects. METHODS: In 1307 community participants, the contribution of pulsatile haemodynamics (applanation tonometry and SphygmoCor software) to variations in left ventricular mass index (LVMI) (echocardiography) (n = 920), carotid intima-media thickness (IMT) (n = 712) and estimated glomerular filtration rate (eGFR) (n = 1164) were assessed...
July 20, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28708774/identifying-unilateral-disease-in-chinese-patients-with-primary-aldosteronism-by-using-a-modified-prediction-score
#4
Ying Zhang, Wenquan Niu, Fangfang Zheng, Hua Zhang, Wenlong Zhou, Zhoujun Shen, Jianzhong Xu, Xiaofeng Tang, Jin Zhang, Ping-Jin Gao, Ji-Guang Wang, Limin Zhu
OBJECTIVE: The current study aimed to evaluate the role of Küpers' score in predicting unilateral aldosteronism, and develop a modified score in Chinese patients with primary aldosteronism. METHODS: The current retrospective study included 406 patients with primary aldosteronism who underwent successful adrenal venous sampling (AVS) and were divided into the unilateral (n = 211) and bilateral (n = 195) groups according to the AVS results. Normokalemia was noted in both the unilateral (n = 64) and bilateral groups (n = 84) when plasma and urinary aldosterone were measured...
July 20, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28723880/prevalence-and-clinical-characteristics-of-white-coat-hypertension-based-on-different-definition-criteria-in-untreated-and-treated-patients
#5
Alejandro de la Sierra, Ernest Vinyoles, José R Banegas, Julián Segura, Manuel Gorostidi, Juan J de la Cruz, Luis M Ruilope
BACKGROUND AND AIM: The prevalence and associated risks of white-coat hypertension (WCH) are still a matter of debate. We aimed to assess differences in prevalence and associated conditions of WCH defined on the basis of the normality of all daytime, night-time, and 24-h blood pressure (BP), only daytime, or only 24-h BP. METHODS: We selected 115 708 patients (45 020 untreated and 70 688 treated) from the Spanish Ambulatory BP Monitoring Registry. WCH was estimated in patients with elevated office BP (≥140 and/or 90 mmHg) by using normal daytime (<135/85) BP, normal 24-h BP (<130/80), or normal daytime, night-time (<120/70) and 24-h BP...
July 18, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28661960/longitudinal-study-of-the-influence-of-lung-function-on-vascular-health-from-adolescence-to-early-adulthood-in-a-british-multiethnic-cohort
#6
Yao Lu, Lum Sooky, Maria João Silva, Oarabile R Molaodi, Alexis Karamanos, J Kennedy Cruickshank, Seeromanie Harding
BACKGROUND: Vascular and lung function develop and decline over the life course; both predict cardiovascular events and mortality but little is known of how they develop over time. We analysed their relationship in a multiethnic cohort study to test whether lung function from early adolescence to young adulthood affected vascular indices. METHODS: 'DASH' (http://dash.sphsu.mrc.ac.uk) included 6643 children aged 11-13 years in 2003; a representative 10% sample (n = 665) participated in a pilot follow-up in 2013...
July 18, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28719470/diurnal-variation-and-repeatability-of-arterial-stiffness-and-cardiac-output-measurements-in-the-third-trimester-of-uncomplicated-pregnancy
#7
Mohamed W Osman, Francesca Leone, Mintu Nath, Asma Khalil, David R Webb, Thompson G Robinson, Hatem A Mousa
AIM: To investigate same day repeated measures and diurnal variation of arterial stiffness, cardiac output (CO), stroke volume (SV) and total peripheral resistance (TPR) during the third trimester of normal pregnancy. METHODOLOGY: Pulse wave velocity (PWV) and augmentation index (AIx) were recorded using the Arteriograph, while CO, SV and TPR were recorded using noninvasive cardiac output monitoring. The measurements were obtained in the third trimester of pregnancy from 21 healthy pregnant women at four time points (morning, afternoon, evening and midnight) over a 24-h period...
July 14, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28708773/angiotensin-ii-responsiveness-after-preeclampsia-translational-data-from-an-experimental-rat-model-and-early-onset-human-preeclampsia
#8
Anne M van der Graaf, Tsjitske J Toering, Mienke W K van der Wiel, Anne-Roos S Frenay, Gerd Wallukat, Ralf Dechend, Gerjan Navis, Henk Groen, A Titia Lely, Marijke M Faas
OBJECTIVE: Formerly preeclamptic women have an increased risk for cardiovascular and renal disease later in life. It is unknown which mechanisms contribute to this increased risk and whether this is induced by preeclampsia or by prepregnancy factors. We hypothesized that the increased risk for cardiovascular disease is partly due to an increased angiotensin II (ang II) responsiveness postpartum and that preeclampsia itself is involved in inducing this increased ang II responsiveness. METHODS: In never-pregnant, formerly healthy pregnant rats and rats with former experimental preeclampsia [experimental preeclampsia model induced by low-dose endotoxin infusion on day 14 of pregnancy; endotoxin-infused pregnant rats (EP-rats)], ang II responsiveness was studied by measuring changes in blood pressure (BP) and proteinuria after chronic ang II infusion with osmotic minipumps (200 ng/kg per min)...
July 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28704264/extravascular-renal-denervation-ameliorates-juvenile-hypertension-and-renal-damage-resulting-from-experimental-hyperleptinemia-in-rats
#9
Nynke R Oosterhuis, Ramon Fernandes, Nuria Maicas, Sung Eun Bae, Joaquim Pombo, Hendrik Gremmels, Lucilla Poston, Jaap A Joles, Anne-Maj Samuelsson
BACKGROUND: Material obesity in rodents is associated with neonatal hyperleptinemia and hypertension of sympathetic origin in adult offspring. Previously, we reported that experimentally induced hyperleptinemia in rat pups results in adulthood hypertension. Here, we addressed the hypothesis that experimental neonatal hyperleptinemia, through renal nerve activation, adversely affects adult renal function. METHOD: Sprague-Dawley male and female pups were treated with neonatal leptin (3 mg/kg, intraperitoneal) or neonatal saline, twice daily from postnatal day 9-14...
July 12, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28704263/facebook-advertising-for-participant-recruitment-into-a-blood-pressure-clinical-trial
#10
Erin L Nash, Deborah Gilroy, Wichat Srikusalanukul, Walter P Abhayaratna, Tony Stanton, Geoffrey Mitchell, Michael Stowasser, James E Sharman
OBJECTIVES: Recruitment of sufficient sample size into clinical trials is challenging. Conventional advertising methods are expensive and are often ineffective. The effectiveness of Facebook for recruitment into blood pressure clinical trials of middle-to-older-aged people is unknown. This study aimed to assess this by comparing Facebook advertising with conventional recruitment methods from a retrospective analysis within a clinical trial. METHODS: Conventional advertisements (newspaper, radio and posters) were employed for the first 20 months of a randomized controlled clinical trial conducted in three Australian capital cities from Tasmania, Queensland and the Australian Capital Territory...
July 12, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28704262/effect-of-upper-body-position-on-arterial-stiffness-influence-of-hydrostatic-pressure-and-autonomic-function
#11
Elizabeth C Schroeder, Alexander J Rosenberg, Thessa I M Hilgenkamp, Daniel W White, Tracy Baynard, Bo Fernhall
OBJECTIVE: To evaluate changes in arterial stiffness with positional change and whether the stiffness changes are due to hydrostatic pressure alone or if physiological changes in vasoconstriction of the conduit arteries play a role in the modulation of arterial stiffness. METHODS: Thirty participants' (male = 15, 24 ± 4 years) upper bodies were positioned at 0, 45, and 72° angles. Pulse wave velocity (PWV), cardio-ankle vascular index, carotid beta-stiffness index, carotid blood pressure (cBP), and carotid diameters were measured at each position...
July 12, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28704261/no-independent-association-between-pulse-wave-velocity-and-dementia-a-population-based-prospective-study
#12
Erik D Nilsson, Sölve Elmståhl, Lennart Minthon, Mats Pihlsgård, Peter M Nilsson, Oskar Hansson, Katarina Nägga
OBJECTIVE: Carotid-femoral pulse wave velocity (CFPWV), a marker of aortic stiffness, has been associated with cognitive test results and markers of cerebral small vessel disease, but its association with dementia has not been studied in detail. Our aim was to assess the association of CFPWV with prevalent and incident dementia in a large population-based study. METHODS: In total, CFPWV was measured in 3056 participants of the Malmö Diet and Cancer study 2007-2012 (age range 61-85 years)...
July 12, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28704260/%C3%AE-solanine-reverses-pulmonary-vascular-remodeling-and-vascular-angiogenesis-in-experimental-pulmonary-artery-hypertension
#13
Xiaowei Nie, Youai Dai, Jianxin Tan, Yuan Chen, Guowei Qin, Wenjun Mao, Jian Zou, Yanhua Chang, Qian Wang, Jingyu Chen
OBJECTIVE: Similar to cancer, pulmonary arterial hypertension (PAH) is characterized by vascular remodeling, which leads to obliteration of the small pulmonary arteriole, with marked proliferation of pulmonary artery smooth muscle cells (PASMC) and/or endothelial cells dysfunction. Aberrant expression of tumor suppressor genes is closely associated with susceptibility to PAH. We hypothesized that α-solanine, a glycoalkaloid found in members of the nightshade family known to have antitumor activity in different cancers, reverses experimental PAH by activating the tumor suppressor-axis inhibition protein 2 (AXIN2)...
July 12, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28704259/systemic-blood-pressure-at-exercise-in-hypoxia-in-hypertensive-and-normotensive-patients
#14
Laurent Winkler, François J Lhuissier, Jean-Paul Richalet
OBJECTIVES: The current study aimed to determine whether acute hypoxia exposure in laboratory conditions associated with exercise induces an increase in systemic blood pressure (BP) in normotensive and hypertensive patients, and whether hypertensive patients are more prone to develop severe acute mountain sickness (sAMS). Finally, to determine if BP changes at exercise in acute hypoxia in hypertensive patients are predictive factors for sAMS. METHODS: From 2012 to 2015, 852 normotensive and 106 hypertensive patients went through an acute hypoxia exercise test before a sojourn at high altitude...
July 12, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28704258/effect-of-alternating-standing-and-sitting-on-blood-pressure-and-pulse-wave-velocity-during-a-simulated-workday-in-adults-with-overweight-obesity
#15
Bethany Barone Gibbs, Robert J Kowalsky, Sophy J Perdomo, John M Taormina, Jeffrey R Balzer, John M Jakicic
OBJECTIVE: Reducing prolonged sitting at work has been recommended by an expert panel, but whether intermittent standing improves vascular health is unclear. We aimed to test whether using a sit-stand desk could reduce blood pressure (BP) and pulse wave velocity (PWV) during a simulated workday. METHODS: Overweight/obese adults with pre-to-Stage 1 hypertension completed a randomized crossover study with two simulated workday conditions: STAND-SIT (alternating standing and sitting condition every 30 min) and SIT (continuous sitting condition)...
July 12, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28661961/in-utero-exposure-to-antihypertensive-medication-and-neonatal-and-child-health-outcomes-a-systematic-review
#16
Catherine A Fitton, Markus F C Steiner, Lorna Aucott, Jill P Pell, Daniel F Mackay, Michael Fleming, James S McLay
BACKGROUND: Although medication is generally avoided wherever possible during pregnancy, pharmacotherapy is required for the treatment of pregnancy associated hypertension, which remains a leading cause of maternal and fetal morbidity and mortality. The long-term effects to the child of in-utero exposure to antihypertensive agents remains largely unknown. OBJECTIVE: The aim of this study was to systematically review published studies on adverse outcomes to the child associated with in-utero exposure to antihypertensive medications...
July 11, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28697010/estimating-population-salt-intake-in-india-using-spot-urine-samples
#17
Kristina S Petersen, Claire Johnson, Sailesh Mohan, Kris Rogers, Roopa Shivashankar, Sudhir R Thout, Priti Gupta, Feng J He, Graham A MacGregor, Jacqui Webster, Joseph A Santos, Anand Krishnan, Pallab K Maulik, K Srinath Reddy, Ruby Gupta, Dorairaj Prabhakaran, Bruce Neal
OBJECTIVE: To compare estimates of mean population salt intake in North and South India derived from spot urine samples versus 24-h urine collections. METHODS: In a cross-sectional survey, participants were sampled from slum, urban and rural communities in North and in South India. Participants provided 24-h urine collections, and random morning spot urine samples. Salt intake was estimated from the spot urine samples using a series of established estimating equations...
July 10, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28697009/home-blood-pressure-predicts-stroke-incidence-among-older-adults-with-impaired-physical-function-the-ohasama-study
#18
Keiko Murakami, Kei Asayama, Michihiro Satoh, Miki Hosaka, Ayako Matsuda, Ryusuke Inoue, Megumi Tsubota-Utsugi, Takahisa Murakami, Kyoko Nomura, Masahiro Kikuya, Hirohito Metoki, Yutaka Imai, Takayoshi Ohkubo
OBJECTIVE: Several observational studies have found modifying effects of functional status on the association between conventional office blood pressure (BP) and adverse outcomes. We aimed to examine whether the association between higher BP and stroke was attenuated or inverted among older adults with impaired function using self-measured home BP measurements. METHODS: We followed 501 Japanese community-dwelling adults aged at least 60 years (mean age, 68.6 years) with no history of stroke...
July 10, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28692446/ethnicity-and-arterial-stiffness-in-children-and-adolescents-from-a-brazilian-population
#19
Divanei Zaniqueli, Rafael O Alvim, Sara G Luiz, Polyana R Oliosa, Roberto de Sá Cunha, José G Mill
BACKGROUND: Increased stiffness of large arteries is an important determinant of cardiovascular disease risk. Higher values of arterial stiffness measured by carotid-femoral pulse wave velocity (cf-PWV) have been measured in adult African-Americans compared with whites. Studies assessing ethnic differences in cf-PWV among children and adolescents are scarce. This study sought to evaluate the association between ethnicity and cf-PWV in Brazilian children and adolescents. METHODS: Seven hundred and seventy-one children and adolescents (211 blacks and 560 nonblacks, 11...
July 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28692445/normal-cerebral-vascular-pulsations-in-humans-changes-with-age-and-implications-for-microvascular-disease
#20
Mi O Kim, Yan Li, Fangfei Wei, Jiguang Wang, Michael F O'Rourke, Audrey Adji, Alberto P Avolio
BACKGROUND: Cerebral syndromes in older humans, secondary stroke in younger persons following trauma, and sickle cell anaemia in children, are linked by unexplained microvascular damage and high cerebral pressure or flow pulsations. The aim of this study was to characterize age-related pressure and flow waveforms patterns entering the brain, to explain these in terms of disturbed physiological function, and to consider clinical implications. METHOD: Blood flow velocity waves were measured in four cerebral vascular territories by transcranial Doppler of 1020 apparently normal patients (497 men, 21-78 years)...
July 7, 2017: Journal of Hypertension
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