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Nutrition Research

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https://www.readbyqxmd.com/read/28314639/acute-dark-chocolate-ingestion-is-beneficial-for-hemodynamics-via-enhancement-of-erythrocyte-deformability-in-healthy-humans
#1
Jana Radosinska, Martina Horvathova, Karel Frimmel, Jana Muchova, Maria Vidosovicova, Rastislav Vazan, Iveta Bernatova
Erythrocyte deformability is an important property of erythrocytes that considerably affects blood flow and hemodynamics. The high content of polyphenols present in dark chocolate has been reported to play a protective role in functionality of erythrocytes. We hypothesized that chocolate might influence erythrocytes not only after repeated chronic intake, but also immediately after its ingestion. Thus, we determined the acute effect of dark chocolate and milk (with lower content of biologically active substances) chocolate intake on erythrocyte deformability...
March 7, 2017: Nutrition Research
https://www.readbyqxmd.com/read/28291551/marine-n-3-polyunsaturated-fatty-acids-affect-the-blood-pressure-control-in-patients-with-newly-diagnosed-hypertension-a-1-year-follow-up-study
#2
Carina N Bagge, Charlotte Strandhave, Charlotte M Skov, My Svensson, Erik B Schmidt, Jeppe H Christensen
Marine long-chained n-3 polyunsaturated fatty acids (PUFA) are recognized for their cardio-protective effects, including potential lowering of blood pressure. We hypothesized that higher habitual fish intake and n-3 PUFA plasma levels were associated with lower blood pressure and being less likely to receive antihypertensive medication after one-year follow-up. In this prospective study of 115 patients, we assessed 24 h ambulatory and central blood pressure, plasma phospholipid fatty acid composition using gas chromatography and participants completed a food frequency questionnaire, including fish-eating habits...
February 28, 2017: Nutrition Research
https://www.readbyqxmd.com/read/28385290/post-prandial-systemic-8-isoprostane-increases-after-consumption-of-moderate-and-high-fat-meals-in-insufficiently-active-males
#3
S P Kurti, S R Emerson, S K Rosenkranz, C S Teeman, E M Emerson, B J Cull, J R Smith, C A Harms
A single high-fat meal (HFM) leads to an increase in triglycerides and oxidative stress. Oxidative stress can be assessed via 8-isoprostane generation, which is associated with the development of asthma and cardiovascular disease. No previous research has investigated whether airway and systemic 8-isoprostane increases postprandially in nonasthmatic participants according to the energy and fat content of a meal. Our purpose was to assess airway and systemic 8-isoprostane after a HFM and a true-to-life moderate-fat meal (MFM)...
March 2017: Nutrition Research
https://www.readbyqxmd.com/read/28385289/use-of-a-novel-docosahexaenoic-acid-formulation-vs-control-in-a-neonatal-porcine-model-of-short-bowel-syndrome-leads-to-greater-intestinal-absorption-and-higher-systemic-levels-of-dha
#4
Camilia R Martin, Barbara Stoll, Joanne Cluette-Brown, Adesola C Akinkuotu, Oluyinka O Olutoye, Kathleen M Gura, Pratibha Singh, Munir M Zaman, Michael C Perillo, Mark Puder, Steven D Freedman, Doug Burrin
Infants with short bowel syndrome (SBS) are at high risk for malabsorption, malnutrition, and failure to thrive. The objective of this study was to evaluate in a porcine model of SBS, the systemic absorption of a novel enteral Docosahexaenoic acid (DHA) formulation that forms micelles independent of bile salts (DHA-ALT®). We hypothesized that enteral delivery of DHA-ALT® would result in higher blood levels of DHA compared to a control DHA preparation due to improved intestinal absorption. SBS was induced in term piglets through a 75% mid-jejunoileal resection and the piglets randomized to either DHA-ALT® or control DHA formulation (N=5 per group) for 4 postoperative days...
March 2017: Nutrition Research
https://www.readbyqxmd.com/read/28385288/increased-naive-cd4-and-b-lymphocyte-subsets-are-associated-with-body-mass-loss-and-drive-relative-lymphocytosis-in-anorexia-nervosa-patients
#5
Ana Elegido, Montserrat Graell, Patricia Andrés, Alina Gheorghe, Ascensión Marcos, Esther Nova
Anorexia nervosa (AN) is an atypical form of malnutrition with peculiar changes in the immune system. We hypothesized that different lymphocyte subsets are differentially affected by malnutrition in AN, and thus, our aim was to investigate the influence of body mass loss on the variability of lymphocyte subsets in AN patients. A group of 66 adolescent female patients, aged 12-17 years, referred for their first episode of either AN or feeding or eating disorders not elsewhere classified were studied upon admission (46 AN-restricting subtype, 11 AN-binge/purging subtype, and 9 feeding or eating disorders not elsewhere classified)...
March 2017: Nutrition Research
https://www.readbyqxmd.com/read/28385287/mice-with-infectious-colitis-exhibit-linear-growth-failure-and-subsequent-catch-up-growth-related-to-systemic-inflammation-and-igf-1
#6
Mark D DeBoer, Vidhya Vijayakumar, Meiqing Gong, John L Fowlkes, Rachel M Smith, Fernando Ruiz-Perez, James P Nataro
In developing communities, intestinal infection is associated with poor weight gain and linear-growth failure. Prior translational animal models have focused on weight gain investigations into key contributors to linear growth failure have been lacking. We hypothesized that murine intestinal infection with Citrobacter rodentium would induce linear-growth failure associated with systemic inflammation and suppressed serum levels of insulin-like growth factor-1 (IGF-1). We evaluated 4 groups of mice infected or sham-infected on day-of-life 28: uninfected-controls, wild-type C rodentium-infected, partially-attenuated C rodentium-infected (with deletion of 3 serine protease genes involved in colonization), and pair-fed (given the amount of daily food consumed by the wild-type C rodentium group)...
March 2017: Nutrition Research
https://www.readbyqxmd.com/read/28385286/dietary-psyllium-fiber-increases-intestinal-heat-shock-protein-25-expression-in-mice
#7
Miyuki Ogata, Tran Van Hung, Hiroyuki Tari, Teruaki Arakawa, Takuya Suzuki
Heat shock proteins (HSPs) protect intestinal epithelial cell function, integrity and viability against many forms of stress. We hypothesized that dietary fibers (DFs) in the diet may increase HSP expression, since DFs are known to exhibit beneficial effects on intestinal health. The present study investigated the regulation of intestinal HSP expression by DFs, particularly psyllium fiber. Feeding psyllium fiber for 5 d increased HSP25 expression, but not HSP32 and HSP70 expression in the jejunum, ileum, and colon of mice at both the protein and mRNA levels...
March 2017: Nutrition Research
https://www.readbyqxmd.com/read/28385285/high-serum-copper-level-is-associated-with-an-increased-risk-of-preeclampsia-in-asians-a-meta-analysis
#8
REVIEW
Xingxing Song, Bingrong Li, Zongyao Li, Jiantao Wang, Dongfeng Zhang
Epidemiological studies evaluating the associations between serum copper and ratios of Cu/Zn and the preeclampsia (PE) risk in Asian population have produced inconsistent results. Therefore, we conducted a meta-analysis to summarize the relationships. We hypothesize that higher serum copper and ratios of Cu/Zn may increase the PE risk. A systematic literature search was performed in PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure (CNKI), VIP (Database of Chinese Scientific and Technical Periodicals) and Wangfang databases for relevant studies up to November 2016...
March 2017: Nutrition Research
https://www.readbyqxmd.com/read/28385284/obesity-is-a-concern-for-bone-health-with-aging
#9
REVIEW
Sue A Shapses, L Claudia Pop, Yang Wang
Accumulating evidence supports a complex relationship between adiposity and osteoporosis in overweight/obese individuals, with local interactions and endocrine regulation by adipose tissue on bone metabolism and fracture risk in elderly populations. This review was conducted to summarize existing evidence to test the hypothesis that obesity is a risk factor for bone health in aging individuals. Mechanisms by which obesity adversely affects bone health are believed to be multiple, such as an alteration of bone-regulating hormones, inflammation, oxidative stress, the endocannabinoid system, that affect bone cell metabolism are discussed...
March 2017: Nutrition Research
https://www.readbyqxmd.com/read/28381355/elevated-systolic-blood-pressure-of-children-in-the-united-states-is-associated-with-low-serum-25-hydroxyvitamin-d-concentrations-related-to-body-mass-index-national-health-and-examination-survey-2007-2010
#10
Carolyn E Moore, Yan Liu
A negative association between serum 25-hydroxyvitamn D (25[OH]D) concentrations and blood pressure has been found in adults; whether a similar relationship exists in children remains unclear. We hypothesized that serum 25(OH)D concentrations of children would negatively correlate with blood pressure. Using a nationally representative sample of children aged 8 to 18years from the National Health and Nutrition Examination Survey 2007-2010 (n=2908), we compared serum 25(OH)D levels with diastolic and systolic blood pressure by vitamin D nutritional status categories...
February 2017: Nutrition Research
https://www.readbyqxmd.com/read/28381354/1-25-dihydroxyvitamin-d3-prevents-deleterious-effects-of-homocysteine-on-mitochondrial-function-and-redox-status-in-heart-slices
#11
Aline Longoni, Janaina Kolling, Cassiana Siebert, João Paulo Dos Santos, Jussemara Souza da Silva, Letícia F Pettenuzzo, Leo Anderson Meira-Martins, Carlos-Alberto Gonçalves, Adriano M de Assis, Angela T S Wyse
Because homocysteine (Hcy) is a risk factor for cardiovascular disease, and vitamin D deficiency can contribute to cardiovascular pathologies. In the present study, we tested the hypothesis that Hcy could impair energy metabolism, mitochondrial function, and redox status in heart slices of Wistar rats and that 1,25-dihydroxivitamin D3 (calcitriol) treatment could prevent such effects. Heart slices were first pretreated with 3 different concentrations of calcitriol (50, 100, and 250nmol/L) for 30minutes at 37°C, after which Hcy was added to promote deleterious effects on metabolism...
February 2017: Nutrition Research
https://www.readbyqxmd.com/read/28381353/whey-protein-hydrolysate-and-branched-chain-amino-acids-downregulate-inflammation-related-genes-in-vascular-endothelial-cells
#12
Marine S Da Silva, Cyril Bigo, Olivier Barbier, Iwona Rudkowska
A recent review of clinical studies reports that dairy products may improve inflammation, a key etiologic cardiovascular disease risk factor. Yet the impact of dairy proteins on inflammatory markers is controversial and could be mediated by a differential impact of whey proteins and caseins. In this study, we hypothesized that whey proteins may have a greater anti-inflammatory effect than caseins. A model of human umbilical vein endothelial cells, with or without TNF-α stimulation, was used to investigate the effect of several dairy protein compounds on inflammation...
February 2017: Nutrition Research
https://www.readbyqxmd.com/read/28381352/intraduodenal-infusion-of-cyanidin-3-glucoside-transiently-promotes-triglyceride-excretion-into-bile-in-rats
#13
Naoto Hashimoto, Kyu-Ho Han, Michihiro Fukushima
Flavonoids purportedly have a role in improving lipid metabolism. In our preliminary study, highly concentrated flavonoid metabolites appeared in bile juice in rats, which also contains various lipids. Biliary flavonoid metabolites generally have amphiphilic properties, may influence lipid solubility, and possibly contribute to the improvement of dyslipidemia. However, the influence of biliary flavonoid metabolites on the biliary lipid profile is not well known. Therefore, we hypothesized that the amphiphilic property of biliary flavonoid metabolites alters biliary lipid profiles...
February 2017: Nutrition Research
https://www.readbyqxmd.com/read/28381351/dihydromyricetin-induces-mitochondria-mediated-apoptosis-in-hepg2-cells-through-down-regulation-of-the-akt-bad-pathway
#14
Zhuangwei Zhang, Huiqin Zhang, Shiyong Chen, Yan Xu, Anjun Yao, Qi Liao, Liyuan Han, Zuquan Zou, Xiaohong Zhang
The plant flavonol dihydromyricetin (DHM) was reported to induce apoptosis in human hepatocarcinoma HepG2 cells. This study was undertaken to elucidate the underlying molecular mechanism of action of DHM. In the study, DHM down-regulated Akt expression and its phosphorylation at Ser473, up-regulated the levels of mitochondrial proapoptotic proteins Bax and Bad, and inhibited the phosphorylation of Bad at Ser136 and Ser112. It also inhibited the expression of the antiapoptotic protein Bcl-2 and enhanced the cleavage and activation of caspase-3 as well as the degradation of its downstream target poly(ADP-ribose) polymerase...
February 2017: Nutrition Research
https://www.readbyqxmd.com/read/28381350/a-systematic-review-of-the-interrelation-between-diet-and-surgery-induced-weight-loss-and-vitamin-d-status
#15
REVIEW
Caroline Himbert, Jennifer Ose, Mahmoud Delphan, Cornelia M Ulrich
Obesity is a major global health problem and has been associated with vitamin D deficiency. Intentional weight loss may alter vitamin D status and, conversely, vitamin D supplementation has been hypothesized to aid in weight loss. A systematic literature search in PubMed/Medline identified 3173 articles of which 37 studies (randomized controlled trials (RCT) [n=17], non-RCTs [n=20]) are summarized as effect of: (I) diet-induced weight loss on vitamin D status (n=7), (II) vitamin D supplementation on diet-induced weight loss (n=11), (III) surgery-induced weight loss on vitamin D status (n=15), and (IV) vitamin D supplementation after surgery-induced weight loss on vitamin D status (n=5)...
February 2017: Nutrition Research
https://www.readbyqxmd.com/read/28381349/a-meta-analysis-of-randomized-and-placebo-controlled-clinical-trials-suggests-that-coenzyme-q10-at-low-dose-improves-glucose-and-hba1c-levels
#16
REVIEW
Marko Stojanović, Miroslav Radenković
The influence of coenzyme Q10 (CoQ10) on blood glucose (BGL) and HbA1c (HL) levels has been previously investigated; however, the results are inconsistent. Therefore, the purpose of this meta-analysis was to determine if CoQ10 could affect BGL and HL levels based on the existing evidence. PubMed, Cochrane Library, Web of Science, Embase, and Scopus databases were searched for randomized clinical trials from September 1, 1956, to March 01, 2016. To calculate pooled overall effects, a random effect model was used...
February 2017: Nutrition Research
https://www.readbyqxmd.com/read/28215318/dietary-corn-fractions-reduce-atherogenesis-in-low-density-lipoprotein-receptor-knockout-mice
#17
Kabo Masisi, Khuong Le, Nora Ghazzawi, Mohammed H Moghadasian, Trust Beta
Accumulating evidence has suggested that intake of whole grains is a protective factor against pathogenesis of coronary artery disease. The exact mechanisms, however, are still not clearly understood. In this study, we hypothesized that adequate intake of corn fractions (aleurone, endosperm and germ) can modify lipid profiles in relation to atherosclerotic lesion development in low-density lipoprotein receptor knockout (LDLr-KO) mice. The purpose of the present study was to investigate the potential cardiovascular benefits of corn fractions in LDLr-KO mice through a number of biomarkers including lipid profile, and morphologic and morphometrical analysis of atherosclerotic lesions in aortic root...
January 2017: Nutrition Research
https://www.readbyqxmd.com/read/28215317/docosahexaenoic-acid-supplementation-during-pregnancy-as-phospholipids-did-not-improve-the-incorporation-of-this-fatty-acid-into-rat-fetal-brain-compared-with-the-triglyceride-form
#18
Antonio Gázquez, Inmaculada Hernández-Albaladejo, Elvira Larqué
Prenatal docosahexaenoic acid (DHA) supply is important to ensure an adequate infant neurodevelopment. Several fat supplements with DHA under different chemical structures are available. There is an increased placental phospholipase activity at the end of pregnancy. The hypothesis of this study was to discern whether DHA consumption during pregnancy as phospholipids (PLs) could be more available for placental DHA uptake and fetal accretion than triglycerides (TGs) form. We aimed to evaluate maternofetal DHA status in pregnant rats fed with DHA as PL from egg yolk or TG from algae oil to determine which source might be most effective during pregnancy...
January 2017: Nutrition Research
https://www.readbyqxmd.com/read/28215316/aronia-berry-polyphenol-consumption-reduces-plasma-total-and-low-density-lipoprotein-cholesterol-in-former-smokers-without-lowering-biomarkers-of-inflammation-and-oxidative-stress-a-randomized-controlled-trial
#19
Liyang Xie, Terrence Vance, Bohkyung Kim, Sang Gil Lee, Christian Caceres, Ying Wang, Patrice A Hubert, Ji-Young Lee, Ock K Chun, Bradley W Bolling
Former smokers are at increased risk for cardiovascular disease. We hypothesized that dietary aronia polyphenols would reduce biomarkers of cardiovascular disease risk, inflammation, and oxidative stress in former smokers. We also determined the extent these effects were associated with polyphenol bioavailability. A 12-week, randomized, placebo-controlled trial was conducted in 49 healthy adult former smokers (n = 24/placebo, n = 25/aronia) to evaluate if daily consumption of 500 mg aronia extract modulated plasma lipids, blood pressure, biomarkers of inflammation and oxidative stress, and lipid transport genes of peripheral blood mononuclear cells...
January 2017: Nutrition Research
https://www.readbyqxmd.com/read/28215315/dietary-phosphorus-intake-is-negatively-associated-with-bone-formation-among-women-and-positively-associated-with-some-bone-traits-among-men-a-cross-sectional-study-in-middle-aged-caucasians
#20
Suvi T Itkonen, Hannu J Rita, Elisa M Saarnio, Virpi E Kemi, Heini J Karp, Merja U M Kärkkäinen, Minna H Pekkinen, E Kalevi Laitinen, Juha Risteli, Marja-Kaisa Koivula, Harri Sievänen, Christel J E Lamberg-Allardt
High dietary phosphorus (P) intake has acute negative effects on calcium (Ca) and bone metabolism, but long-term clinical data are contradictory. We hypothesized that high P intake is associated with impaired bone health as suggested by earlier short-term studies on bone metabolism. In this cross-sectional study, we investigated associations between dietary P intake, bone traits in the radius and tibia, and bone turnover in a population-based sample of 37- to 47-year-old Caucasian premenopausal women (n=333) and men (n=179) living in Southern Finland (60°N)...
January 2017: Nutrition Research
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