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Neurourology and Urodynamics

Hong Pan, Yong Bao, Honghao Cao, Rongjiang Jin, Pu Wang, Junmei Zhang
AIMS: To evaluate the value of magnetic stimulation (MS) in patients with pelvic floor dysfunction (PFD). METHODS: The Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement was followed. We searched five databases for articles published until November 2017. Included studies investigated the effects of MS on PFD. Meta-analysis of RCTs was performed using a random effects model, and narrative analysis was undertaken where meta-analysis was not possible...
September 17, 2018: Neurourology and Urodynamics
Angie Rantell, Fevzi Shakir, Linda Cardozo
AIMS: To present a narrated video designed to demonstrate the steps involved in performing and interpreting ambulatory urodynamics monitoring (AUM). METHODS: This video provides an overview of the role of AUM in clinical practice and describes the process of performing AUM using solid state microtip transducers and the MMS / Laborie Luna ambulatory recorder. Line placement, calibration and the urodynamic protocol are discussed along with descriptions of provocation tests that can be used during AUM...
September 17, 2018: Neurourology and Urodynamics
Christopher R Chapple, Nadir I Osman, Lori Birder, Roger Dmochowski, Marcus J Drake, Gommert van Koeveringe, Victor W Nitti, Matthias Oelke, Phillip P Smith, Osamu Yamaguchi, Alan Wein, Paul Abrams
No abstract text is available yet for this article.
September 11, 2018: Neurourology and Urodynamics
Alexandre Hourié, Francois-Xavier Nouhaud, Maximilien Baron, John-David Rebibo, Christian Pfister, Philippe Grise, Jean-Nicolas Cornu
AIMS: To evaluate the impact of the pre-operative maximum detrusor pressure (MDP) on efficacy outcomes after incontinentation by sphincterotomy or urethral stent placement in male patients with neurogenic detrusor-sphincter dyssynergia (DSD). METHODS: A retrospective study was performed in 41 male patients treated between 2006 and 2013 in a tertiary reference center. All patients had a neurogenic DSD confirmed by baseline urodynamic studies, and were unable or secondary failed to practice CISC...
September 11, 2018: Neurourology and Urodynamics
Roger R Dmochowski, Eric S Rovner, Kevin G Connors, J Christian Winters
OBJECTIVES: To perform a post hoc analysis of the outcome data from a phase III study of a novel incontinence therapy for female stress incontinence (SUI) and to understand the pitfalls inherent to performing trials in SUI. METHODS: Results of the SUCCESS Trial, a multicenter, prospective, single-blinded, randomized, sham-controlled study were assessed post hoc for parameters and variables consistent with changes in the symptoms or signs of SUI. Subjects were randomized to either the investigative device (Vesair Balloon) placement or placebo...
September 11, 2018: Neurourology and Urodynamics
Jian G Wen, Jens Christian Djurhuus, Peter F W M Rosier, Stuart B Bauer
AIMS: To introduce the standard procedure of cystometry and interpretation of the results in children. METHODS: The literature on cystometry in children in PubMed for the last 20 years was reviewed. The updated knowledge regarding indication, preparation, technique, and interpretation of cystometry in children were summarized. RESULTS: Filling cystometry is the core content of a paediatric urodynamic study. In this section, the technique for performing cystometry is introduced in details...
September 11, 2018: Neurourology and Urodynamics
Marah Hehemann, Elizabeth Kalmanek, Shawn Choe, Danuta Dynda, Wen-Yang Hu, Marcus L Quek, Daniel A Harrington, Samuel I Stupp, Kevin T McVary, Carol A Podlasek
AIMS: Rhabdosphincter (RS) muscle injury occurs during prostatectomy, and is a leading cause of stress urinary incontinence (SUI). Current SUI treatments engender significant side effects, which negatively impact patient quality of life. Thus an unmet need exists to develop novel RS regeneration methods. We have shown that Sonic hedgehog (SHH) is a critical regulator of penile smooth muscle, and we have developed novel peptide amphiphile nanofiber hydrogel delivery of SHH protein to the penis to regenerate smooth muscle after prostatectomy induced injury...
September 6, 2018: Neurourology and Urodynamics
Stergios K Doumouchtsis, Youstina Fahmay, Philip Sedgwick, Constantin M Durnea
AIMS: Increasing numbers of twin pregnancies necessitate investigation of the risk factors associated with obstetric anal sphincter injuries (OASIS). The aims of this study were to establish the incidence of OASIS, and compare women delivering twins to those delivering singletons in risk of OASIS plus maternal, neonatal, and obstetric outcomes. METHODS: A retrospective cohort study was undertaken and included women delivering in a tertiary London maternity unit between 1999 and 2015; 51 957 eligible women with singleton and 261 with twin pregnancies were identified...
September 6, 2018: Neurourology and Urodynamics
Allert M de Vries, Pieter L Venema, John P F A Heesakkers
BACKGROUND AND OBJECTIVES: The pathophysiology of female stress urinary incontinence (SUI) is far from unraveled. Capturing all aspects of this bothersome condition in one theory remains challenging. The well-known Hammock and Integral theories, both from the early 90's, were successful in explaining a large proportion of the observations made in clinical practice. Nevertheless, some (pre)clinical observations cannot be explained by the current understanding. One of the issues concerns the pressure transmission...
September 6, 2018: Neurourology and Urodynamics
Alexandra Herrewegh, Lisa Vork, Eline Eurelings, Carsten Leue, Joanna Kruimel, Gommert van Koeveringe, Desiree Vrijens
AIMS: In the current diagnostic process for overactive bladder syndrome (OAB), biased retrospective questionnaires are often used. There is a need for a new assessment tool that embraces the heterogeneity of the OAB complex. A momentary assessment tool, the Experience Sampling Method (ESM) is promising, capturing random repetitive measurements during the day in the context of daily life and is capable to measure potential contextual triggers and psychological aspects. A focus group study was set up to evaluate which items should be implemented in a urological ESM...
September 6, 2018: Neurourology and Urodynamics
Frederick Van Moh, Joel Vetter, H Henry Lai
AIMS: To compare severity and characteristics of urologic pain, other urinary symptoms, sexual pain, psychosocial health, and the distribution and intensity of non-urologic pain between men and women with and without Hunner lesions. METHODS: All cystoscopies were performed and documented by the same clinician to ensure uniform recognition of Hunner lesions. Intensity of urologic and sexual pain, nocturia, frequency, urgency, and bladder hypersensitivity features were assessed using validated questionnaires and numeric rating scales...
September 6, 2018: Neurourology and Urodynamics
Félix Fontaine, Le Mai Tu, Marie-Soleil Carroll, Mélanie Morin
AIMS: Optimal placement of periurethral material has an important role in treatment efficacy with stress urinary incontinence (SUI). The validity of methods for determining urethral length and the precise location of the mid-urethral complex for SUI treatment have been sparsely studied. The aim of this study was to investigate the agreement between urethral lengths measured with a catheter and by transperineal ultrasound. METHODS: Fifty-seven women with SUI or mixed urinary incontinence (MUI) with predominant stress symptoms were recruited...
September 3, 2018: Neurourology and Urodynamics
Andreas Haeberlin, Klaus Schürch, Thomas Niederhauser, Romy Sweda, Marc P Schneider, Dominik Obrist, Fiona Burkhard, Francesco Clavica
AIMS: To explore the feasibility of minimally invasive catheter-based electrophysiology studies in the urinary tract. This is a well-known method used in cardiology to investigate and treat arrhythmias. METHODS: We developed an experimental platform which allows electrophysiological recordings with cardiac catheters and conventional needle electrodes in ex vivo pig ureters. The action potential was triggered by a stimulating electrode. We considered 13 porcine ureters (freshly collected and harvested in organ bath), 7 of which were used to optimize the setup and define the stimulation parameters; we performed the recordings in the remaining six ureters...
September 3, 2018: Neurourology and Urodynamics
Madeleine Engen, Rune Svenningsen, Hjalmar A Schiøtz, Sigurd Kulseng-Hanssen
AIMS: To compare subjective and objective outcomes of mid-urethral sling (MUS) surgery in women in different age decades and the utilization rates for MUS in Norwegian women. METHODS: Data from the national Norwegian Female Incontinence Registry on 21 832 women with stress or mixed urinary incontinence who underwent MUS surgery from 1998 to 2016 were used. Primary outcomes were treatment satisfaction and absence of objective stress leakage at 6-12 months follow-up and "MUS utilization rate...
September 3, 2018: Neurourology and Urodynamics
Steven Nash, Sherif Aboseif, Peter Gilling, Mathew Gretzer, Harvey Samowitz, Marc Rose, Joel Slutsky, Steven Siegel, Le Mai Tu
AIMS: This paper presents 18-month follow-up results for patients enrolled in a pivotal study conducted to support an FDA premarket approval application (PMAA). The trial evaluated the safety and efficacy of the ProACT Adjustable Continence Therapy for the treatment of post-prostatectomy stress urinary incontinence (SUI). METHODS: The clinical study involved 11 clinical sites and enrolled 160 subjects. A total of 124 subjects met study criteria and 123 underwent ProACT implantation from July 2005 through June 2007, of whom 98 completed 18-month follow-up...
September 3, 2018: Neurourology and Urodynamics
Toscane C Noordhoff, Jeroen R Scheepe, Lisette A 't Hoen, Tebbe A R Sluis, Bertil F M Blok
AIMS: The Multiple Sclerosis Intimacy and Sexuality Questionnaire (MSISQ-15) evaluates symptoms of sexual dysfunction in patients with multiple sclerosis (MS). The objective of this study was to provide and validate a Dutch version of the MSISQ-15 in patients with neurological disease such as MS and spinal cord injury (SCI). METHODS: The linguistic validation process of the original English MSISQ-15 into Dutch was performed according to standardized guidelines. Sexually active patients with MS or spinal cord disorders, including SCI and cauda equine syndrome, who visited a tertiary urology center or a rehabilitation center completed the MSISQ-15, Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12) in women, or International Index of Erection Function (IIEF-15) in men at baseline (test) and 2 weeks later (retest)...
August 31, 2018: Neurourology and Urodynamics
Lindsay M Kissane, Isuzu Meyer, Kimberly D Martin, Jubilee C Tan, Kathryn Miller, Holly E Richter
AIMS: To compare surgical success rates in older versus younger women a minimum of 3 years post transvaginal native tissue repair for apical prolapse. Post-operative symptom severity and quality of life improvement, surgical complications and retreatment were also examined. METHODS: Women who underwent transvaginal native tissue repair for apical prolapse between 2011 and 2013 were eligible. Subjects completed the pelvic floor distress inventory (PFDI-20), pelvic floor impact questionnaire (PFIQ-7), and patient global impression of improvement (PGI-I), and were categorized as "younger" (age <70) or "older" (age ≥70)...
August 31, 2018: Neurourology and Urodynamics
Blayne Welk, Duane Hickling, Mary McKibbon, Sidney Radomski, Karen Ethans
AIMS: To determine the effectiveness of mirabegron in patients with neurogenic lower urinary tract dysfunction. METHODS: Randomized, double-blind, placebo-controlled study. Canadian patients with spinal cord injury (SCI) or multiple sclerosis (MS) with urinary symptoms and incontinence were recruited. Patients were randomized to mirabegron 25 mg (or an identical placebo) for 2 weeks at which point a dose escalation to mirabegron 50 mg (or an identical placebo) was maintained for 8 weeks...
August 31, 2018: Neurourology and Urodynamics
Noa Ben Ami, Gali Dar
AIMS: The purpose of the present study was to compare the effectiveness of four different verbal instructions in correctly contracting pelvic floor muscles (PFMs), examined as a displacement of the pelvic floor by transabdominal ultrasound. METHODS: Fifty-six female undergraduate physiotherapy students, mean age 24.2 ± 2.5 years, participated in the study. A 6 MHz 35-mm curved linear array ultrasound transducer (Mindray M5) was placed in the transverse plane, suprapubically over the lower abdomen and angled at 15-30° from the vertical depending...
August 28, 2018: Neurourology and Urodynamics
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