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Neurourology and Urodynamics

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https://www.readbyqxmd.com/read/29767449/outcomes-of-intradetrusor-onabotulinum-toxin-a-injection-in-patients-with-parkinson-s-disease
#1
Gregory Vurture, Benoit Peyronnet, Andrew Feigin, Milton C Biagioni, Rebecca Gilbert, Nirit Rosenblum, Steven Frucht, Alessandro Di Rocco, Victor W Nitti, Benjamin M Brucker
OBJECTIVE: To assess the safety and efficacy of intradetrusor onabotulinum toxin A injections for the treatment of overactive bladder (OAB) in patients with Parkinson's disease (PD). METHODS: All PD patients who underwent intradetrusor injections of onabotulinum toxin A (BoNT-A) for storage symptoms between 2010 and 2017 were included in a retrospective study. A 100 U dose of BoNT-A (Botox®, Allergan Irvine, CA) was used for the first injection in all patients...
May 16, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29756684/a-prospective-bottom-up-study-of-the-costs-of-faecal-incontinence-in-ambulatory-patients
#2
Vicki Patton, Katrina Parkin, Kate H Moore
BACKGROUND AND AIM: The few studies that have examined direct costs of faecal incontinence are limited in that they employed retrospective databases, postal surveys, and focused upon institutionalised patients or post partum women. The aim of the current study was to identify the direct pre-treatment costs of faecal incontinence expended by a range of home dwelling patients and identify relationships between costs and severity of incontinence. METHODS: Consecutive patients attending an outpatient clinic for treatment of faecal incontinence were interviewed using a questionnaire, modeled on the Dowel Bryant Incontinence Cost Index...
May 14, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29717511/refined-nomogram-incorporating-standing-cough-test-improves-prediction-of-male-transobturator-sling-success
#3
Nabeel A Shakir, Joceline S Fuchs, Maxim J McKibben, Boyd R Viers, Travis J Pagliara, Jeremy M Scott, Allen F Morey
AIMS: To develop a decision aid in predicting sling success, incorporating the Male Stress Incontinence Grading Scale (MSIGS) into existing treatment algorithms. METHODS: We reviewed men undergoing first-time transobturator sling for stress urinary incontinence (SUI) from 2007 to 2016 at our institution. Patient demographics, reported pads per day (PPD), and Standing Cough Test (SCT) results graded 0-4, according to MSIGS, were assessed. Treatment failure was defined as subsequent need for >1 PPD or further procedures...
May 1, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29717510/long-term-urodynamic-follow-up-after-external-sphincterotomy-in-patients-with-spinal-cord-injury
#4
Ryosuke Takahashi, Yasusuke Kimoto, Masatoshi Eto
AIMS: External sphincterotomy (ES) is a therapeutic option for male spinal cord injury patients with detrusor sphincter dyssynergia. However, some patients need to change their voiding management after ES. One of the potential causes of failure is reportedly detrusor dysfunction, but long-term urodynamic follow-up data after ES is limited. In the present study, we reviewed the urodynamic data before and after ES and analyzed it for possible causes of ES failure. METHODS: A total of 37 patients who were followed up at our center for at least 5 years after ES were included...
May 1, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29717503/will-cesarean-section-increase-the-risk-of-interstitial-cystitis-painful-bladder-syndrome
#5
Kun-Min Chang, Ming-Huei Lee, Hsuan-Hung Lin, Shang-Liang Wu, Huei-Ching Wu
AIMS: A high number of patients with interstitial cystitis/painful bladder syndrome (IC/PBS) have a history of pelvic surgeries, and cesarean section is one of the most common pelvic surgeries in women. This study aimed to investigate if cesarean section increases the risk of IC/PBS. METHODS: Women who exclusively gave birth through cesarean section or vaginal delivery were identified from a nationwide database between 2002 and 2013. All were followed up during the study period to detect the event of IC/PBS...
May 1, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29717501/sensory-evoked-cortical-potentials-of-the-lower-urinary-tract-in-healthy-men
#6
Stephanie C Knüpfer, Martina D Liechti, Stéphanie van der Lely, Flavia Gregorini, Martin Schubert, Stefan De Wachter, Thomas M Kessler, Ulrich Mehnert
AIMS: To assess the afferent innervation of various locations in the male lower urinary tract (LUT) using sensory evoked cortical potentials (SEPs). METHODS: Twelve healthy men (mean age: 29.6 ± 7.2 years, mean height: 1.8 ± 0.1 m) underwent repetitive slow (0.5 Hz/1 ms) and fast (3 Hz/0.2 ms) electrical stimulations of bladder (dome/trigone) and urethral (proximal/membranous/distal) locations with simultaneous cortical SEP recording (Cz-Fz)...
May 1, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29687914/design-of-programs-to-train-pelvic-floor-muscles-in-men-with-urinary-dysfunction-systematic-review
#7
REVIEW
Leanne M Hall, Rafeef Aljuraifani, Paul W Hodges
AIMS: Pelvic floor muscle training (PFMT) is a first line conservative treatment for men with urinary dysfunction, but reports of its efficacy are variable. This study aimed to systematically review the content of PFMT programs used for urinary dysfunction in men. METHODS: Electronic databases (PubMed, CINAHL, EMBASE, Cochrane, PEDro) were searched for studies that used PFMT in the treatment of adult men with urinary dysfunction. Details of PFMT treatment sessions and home exercise protocols were extracted...
April 24, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29682797/mouse-urothelial-genes-associated-with-voiding-behavior-changes-after-ovariectomy-and-bladder-lipopolysaccharide-exposure
#8
Marian Acevedo-Alvarez, Judy Yeh, Lery Alvarez-Lugo, Ming Lu, Nitin Sukumar, Warren G Hill, Toby C Chai
AIMS: Symptoms from overactive bladder (OAB) and cystitis secondary to urinary tract infection (UTI) can be similar in post-menopausal women. Effects of ovariectomy (OVX) on voiding behavior after lipopolysaccharide (LPS) intravesical exposure (surrogate for cystitis) in mice were measured. Urothelial genes associated with micturition changes were identified. METHODS: Female C57BL6/J mice underwent OVX or sham surgeries (n = 10 for each). Voiding spot assays (VSA) were performed prior to surgery, 4 weeks post-surgery, and each time after 3 consecutive days of transurethral instillation of LPS...
April 23, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29682790/trends-in-the-use-of-older-overactive-bladder-agents-and-uptake-of-fesoterodine-and-mirabegron-in-canada
#9
Rajwant Minhas, Mina Tadrous, Dean Elterman, Tara Gomes
AIMS: To examine early trends in the use of overactive bladder (OAB) agents across Canada, with a focus on initial uptake and reimbursement of two newer agents: fesoterodine, an anticholinergic, and mirabegron, a therapeutically novel beta-3 agonist. METHODS: We conducted a population-based cross-sectional study of outpatient prescriptions for long-acting oral OAB agents dispensed to individuals in Canada between May 2010 and April 2015 to examine the differences in the uptake of the newer agents and their reimbursement through cash, private, and public payers...
April 23, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29682787/urethral-pressure-profilometry-a-video-demonstration
#10
Angie Rantell, Fevzi Shakir, Linda Cardozo
No abstract text is available yet for this article.
April 23, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29675908/development-and-psychometric-evaluation-of-iciq-padprom-a-quality-of-life-questionnaire-to-assess-the-treatment-effect-of-absorbent-continence-products
#11
Charlotte Yearwood Martin, Catherine Murphy, Nikki Cotterill, Sarah Williams, Alan Cottenden, Mandy Fader
AIM: To describe the development and evaluation of the ICIQ-PadPROM, the first self-reported quality of life questionnaire to assess the treatment effect of absorbent continence products, a new addition to the set of ICIQ modules providing international standardized assessment of lower pelvic dysfunction. METHODS: Developed in four phases, question items semi-structured interviews were conducted with pad using men (n = 19), women (n = 6), with secondary analysis undertaken on transcripts (n = 15 women) from a previous study...
April 20, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29675856/adreno-muscarinic-synergy-in-the-male-human-urinary-outflow-tract
#12
Sebastian Walther, Frank Strittmatter, Martin Hennenberg, Christian Gratzke, Christian G Stief, Alexander Roosen
AIM: To examine putative interaction between adrenergic and muscarinic contractile activation in the human urinary outflow tract. METHODS: Tissue from the trigone and prostatic urethra was obtained from 12 cystectomy and 16 prostatectomy specimen. Contractions were elicited by exposure to exogenous agonists before and after inhibition of Rho kinase and protein kinase c (PKC). Immunofluorescence and Western-blot studies were performed using antibodies to muscarinic M3-receptors (M3-R) and alpha1A-adrenoreceptors (alpha1A-AR)...
April 20, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29672906/do-brain-structural-abnormalities-differentiate-separate-forms-of-urgency-urinary-incontinence
#13
Becky D Clarkson, Derek Griffiths, Neil M Resnick
AIMS: Urgency urinary incontinence (UUI) is a major problem for seniors. The underlying mechanisms of disease and therapy are unknown. We sought structural brain abnormalities that might underlie the functional differences previously observed by functional Magnetic Resonance Imaging in UUI patients versus controls, or among UUI responders versus non-responders to therapy-and thereby reveal potential disease mechanisms and therapeutic targets. METHODS: Secondary study of a trial of biofeedback-assisted pelvic floor muscle training (BFB) in 60 women (>60 yrs) with UUI, plus 11 age-matched continent controls...
April 19, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29667730/succinate-decreases-bladder-function-in-a-rat-model-associated-with-metabolic-syndrome
#14
Monica Velasquez Flores, Abubakr H Mossa, Philippe Cammisotto, Lysanne Campeau
AIMS: Succinate and its receptor, GPR91, have been implicated in different aspects of metabolic syndrome. As GPR91 is expressed in the urinary bladder, the aim of this study is to show the effect of chronically increased succinate levels on bladder function. MATERIALS AND METHODS: Healthy Sprague-Dawley (SD) rats and hypertensive Dahl rats received an intraperitoneal injection of either saline or succinate (50 mg/kg) daily for a period of 4 weeks. Conscious cystometry was performed at the end of this period...
April 18, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29664182/can-the-idealized-voider-derived-flow-indexes-be-a-measure-of-voiding-efficiency-and-how-accurate-are-they
#15
Israel Franco, Jacob A Franco, Brandon Nussenblatt
OBJECTIVE: Our hypothesis was to confirm whether an idealized voider flow equation (IVFE) that we created is more accurate than trying to rely on estimated flow rates in the same patient in two consecutive voids. We also looked to confirm whether flow index (FI) can be a proxy for voiding efficiency and to identify which FI was best; those based off our own IVFE equations or those derived from the commonly used power equations. STUDY DESIGN: We used data from a previous study and calculated flow rates using our IVFE and the power equations...
April 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29664178/hypothyroidism-impairs-somatovisceral-reflexes-involved-in-micturition-of-female-rabbits
#16
Octavio Sánchez-García, Rhode López-Juárez, Julia Rodríguez-Castelán, Dora L Corona-Quintanilla, Margarita Martínez-Gómez, Estela Cuevas-Romero, Francisco Castelán
AIMS: To determine the impact of hypothyroidism on the bladder and urethral functions as well as in the activation of the pubococcygeous (Pcm) and bulbospongiosus (Bsm) during micturition. METHODS: Age-matched control and methimazole-induced hypothyroid female rabbits were used to simultaneously record cystometrograms, urethral pressure, and the reflex activation of Pcm and Bsm during the induced micturition. Urodynamic and urethral variables were measured. Activation or no activation of the Pcm and Bsm during the storage and voiding phases of micturition were categorized as 1 or 0...
April 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29664173/neural-or-moral-therapy-in-the-treatment-of-neurogenic-detrusor-overactivity-in-multiple-sclerosis-patients
#17
LETTER
Timur Ekiz, Kamal Mezian
No abstract text is available yet for this article.
April 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29664149/evidence-for-an-urethro-vesical-crosstalk-mediated-by-serotonin
#18
Ana Coelho, Raquel Oliveira, Helena Cavaleiro, Celia Duarte Cruz, Francisco Cruz
AIM: To study the contribution of urethral serotonin for the urethro-vesical crosstalk METHODS: Urethane-anesthetized female rats and TPH1-/- mice underwent isovolumetric or urethral-opened cystometries during intravesical or intraurethral infusion of saline or serotonin solutions. Human and rat bladders and urethrae were immunoreacted against serotonin and neuronal markers. Serotonin concentration and TPH1 mRNA were determined in rat tissue by HPLC and qPCR. RESULTS: In rats, under isovolumetric conditions, intraurethral serotonin infusion, but not saline, evoked bladder contractions...
April 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29664139/test-retest-reliability-of-the-different-dynamometric-variables-used-to-evaluate-pelvic-floor-musculature-during-the-menstrual-cycle
#19
Reny C Dos Reis Nagano, Daniela A Biasotto-Gonzalez, Gilmar L da Costa, Karina M Amorim, Marco A Fumagalli, César F Amorim, Fabiano Politti
OBJECTIVE: The aim of this study was to evaluate the reliability of the different dynamometric variables of the pelvic floor muscles (PFM) in healthy women during the menstrual cycle. MATERIALS AND METHODS: The collections of the PFM contractions of 20 healthy were performed over three consecutive weeks from the first day after the end of the menstrual period. The baseline, peak time, maximum PFM strength value, impulse of contraction, and average contraction force were calculated and the reproducibility tested...
April 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29664135/clinical-outcomes-of-detrusor-underactivity-in-female-with-advanced-pelvic-organ-prolapse-following-vaginal-pelvic-reconstructive-surgery
#20
Tsia-Shu Lo, Sandy Chua, Ma Clarissa Uy-Patrimonio, Chuan C Kao, Chih H Lin
AIM: To determine the impact of vaginal pelvic reconstructive surgery (PRS) on detrusor underactivity (DU) patients having advanced pelvic organ prolapse (POP). METHODS: A retrospective study of patients who underwent PRS for advanced POP (POP-Q ≥ 3) with DU. Data regarding preoperative evaluation, surgical procedure, and post-operative management were collated. Patients were considered to have DU when detrusor pressure at maximum flow (Pdet Qmax ) was ≤10 cmH2 0 and peak flow rate (Qmax ) of ≤12 mL/s...
April 17, 2018: Neurourology and Urodynamics
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