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Hepatology: Official Journal of the American Association for the Study of Liver Diseases

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https://www.readbyqxmd.com/read/30240531/reply-letter-17-2110-r2
#1
LETTER
Virginia Hernández-Gea, Juan Carlos Garcia-Pagan
The prognostic value of MELD in the setting of acute variceal bleeding is largely known. Indeed, a MELD-based model (calibrated-MELD) accurately assigns a probability of 6 weeks mortality for each value of MELD3 . However, when selecting patients for preemptive-TIPS, selection based on Child and active bleeding is the only proven strategy that improves outcome and increases survival. This article is protected by copyright. All rights reserved.
September 21, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30232804/age-sex-but-not-atp7b-genotype-effectively-influences-the-clinical-phenotype-of-wilson-disease
#2
Peter Ferenci, Wolfgang Stremmel, Anna Członkowska, Ferenc Szalay, Andre Viveiros, Albert Friedrich Stättermayer, Radan Bruha, Roderick Houwen, Tudor Pop, Rudolf Stauber, Michael Gschwantler, Jan Pfeiffenberger, Cihan Yurdaydin, Elmar Aigner, Petra Steindl-Munda, Hans-Peter Dienes, Heinz Zoller, Karl Heinz Weiss
Wilson disease (WD) is an inherited disorder of hepatic copper metabolism with considerable variation in clinical presentations, the most common ones being liver disease and neuropsychiatric disturbances. This study investigated the clinical presentation in relation to mutations in a large cohort of WD patients. PATIENTS AND METHODS: 1357 patients (702 children, 655 adults; 1172 index patients, 185 siblings, all with a Leipzig score ≥ 4, male/female:679/678) were studied. The age and the symptoms at presentation were used as key phenotypic markers...
September 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30230575/ube3a-suppresses-overnutrition-induced-expression-of-the-steatosis-target-genes-of-mll4-by-degrading-mll4
#3
Janghyun Kim, Bora Lee, Dae-Hwan Kim, Je Gwang Yeon, Jeongkyung Lee, Younjung Park, Yuna Lee, Soo-Kyung Lee, Seunghee Lee, Jae W Lee
Regulation of the protein stability of epigenetic regulators remains ill-defined despite its potential applicability in epigenetic therapies. The histone H3-lysine 4-methyltransferase MLL4 is an epigenetic transcriptional coactivator that directs overnutrition-induced obesity and fatty liver formation, and Mll4+/- mice are resistant to both. Here we show that the E3 ubiquitin ligase UBE3A targets MLL4 for degradation thereby suppressing high fat diet (HFD)-induced expression of the hepatic steatosis target genes of MLL4...
September 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30229989/prevalence-and-impact-of-de-novo-dsa-during-a-multicenter-immunosuppression-withdrawal-trial-in-adult-liver-transplant-recipients
#4
Vadim Jucaud, Abraham Shaked, Michele DesMarais, Peter Sayre, Sandy Feng, Josh Levitsky, Matthew J Everly
The development of HLA donor-specific antibody/antibodies (DSA) is not well described in liver transplant (LT) patients undergoing immunosuppression (IS) withdrawal protocols despite the allograft risk associated with de novo DSA (dnDSA). We analyzed the development of dnDSA in 69 LT patients who received calcineurin inhibitor monotherapy and were enrolled in the ITN030ST study. Of these 69 patients, 40 stable patients were randomized to IS maintenance (n=9) or IS minimization (n=31). Nine of the 31 IS minimization patients achieved complete withdrawal and were free of IS...
September 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30229987/reply-to-lte-hep-18-1618
#5
LETTER
Vinod Arora, Shiv Kumar Sarin
We would like to thank the reader for going through our study and providing valuable critique. We do agree that noradrenaline is a potent drug in hepatorenal syndrome-acute kidney injury (HRS-AKI) in patients with decompensated cirrhosis and is comparable to terlipressin. Acute on chronic liver failure (ACLF) is a sicker cohort of patients, with a different underlying pathophysiology of acute kidney injury and higher incidence and greater progression to HRS-AKI. This article is protected by copyright. All rights reserved...
September 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30229978/is-it-time-to-reconsider-the-milan-criteria-for-selecting-patients-with-hepatocellular-carcinoma-for-deceased-donor-liver-transplantation
#6
REVIEW
Charlotte E Costentin, Yanik J Bababekov, Andrew X Zhu, Heidi Yeh
Liver transplantation (LT) is considered the optimal treatment for hepatocellular carcinoma (HCC) because it removes tumor as well as the underlying cirrhotic liver. Due to a global organ shortage, LT for patients with HCC is limited to patients with expected survival comparable to that of non-malignant indications. Therefore, identifying patients with lower rates of HCC recurrence and higher rates of survival is critical. International guidelines have considered the Milan Criteria (MC) as the standard for selecting HCC patients for deceased donor LT (DDLT)...
September 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30229977/clinical-outcome-and-viral-genome-variability-of-hepatitis-b-virus-induced-acute-liver-failure-hep-18-0579
#7
Olympia E Anastasiou, Marek Widera, Sandra Westhaus, Lejla Timmer, Johannes Korth, Guido Gerken, Ali Canbay, Daniel Todt, Eike Steinmann, Tatjana Schwarz, Jörg Timm, Jens Verheyen, Sandra Ciesek
INTRODUCTION: Acute hepatitis B virus (HBV) infection remains a frequent cause of acute liver failure (ALF) worldwide. ALF occurs in 0.1-0.5% of infected patients. Aim of this study was to scrutinize the outcome of patients with HBV induced ALF and mutational patterns of HBV variants, which might contribute to ALF. METHODS: From 2005 to 2016, 42 patients were treated for HBV-induced ALF in the University Hospital Essen, Germany. Clinical and virological data from these patients were collected...
September 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30229972/noradrenaline-for-hepatorenal-syndrome-in-patients-with-acute-on-chronic-liver-failure-hope-still-remains
#8
LETTER
Sandeep Satsangi
Hepatorenal syndrome (HRS) is a grave complication occurring in patients with acute-on chronic liver failure (ACLF) and is associated with high short term mortality. It thus becomes extremely crucial to start appropriate & timely medical therapy in order to reverse this potentially lethal complication. This article is protected by copyright. All rights reserved.
September 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30229970/fine-tuning-of-sirt1-expression-is-essential-to-protect-the-liver-from-cholestatic-liver-disease
#9
Britt A Blokker, Monica Maijo, Marta Echeandia, Mikel Galduroz, Angela M Patterson, Anna Ten, Mark Philo, Rebecca Schungel, Virginia Gutierrez-de Juan, Emina Halilbasic, Claudia Fuchs, Gwenaelle Le Gall, Malgorzata Milkiewicz, Piotr Milkiewicz, Jesus M Banales, Simon M Rushbrook, José M Mato, Michael Trauner, Michael Müller, María Luz Martínez-Chantar, Marta Varela-Rey, Naiara Beraza
Cholestasis comprises aetiologically heterogeneous conditions characterized by accumulation of bile acids in the liver that actively contribute to liver damage. Sirtuin 1 (SIRT1) regulates liver regeneration and bile acid metabolism via modulating the farnesoid X receptor (FXR); we here investigate its role in cholestatic liver disease. We determined SIRT1 expression in livers from patients with cholestatic disease, in two experimental models of cholestasis, as well as in human and murine liver cells in response to bile acid loading...
September 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30226642/a-roadmap-for-value-based-payment-models-among-patients-with-cirrhosis
#10
Michael Volk, Jessica Mellinger, Meena B Bansal, Ziad F Gellad, Mark McClellan, Fasiha Kanwal
Cirrhosis is the final common pathway for most chronic liver diseases, afflicting approximately 0.27% of the adult population and accounting for over 60,000 deaths in the U.S. each year.1,2 Although the general public perceives liver disease to be rare, cirrhosis-attributable mortality surpasses that from diabetes or kidney disease This article is protected by copyright. All rights reserved.
September 18, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30222864/recommendations-on-the-use-of-magnetic-resonance-imaging-for-collaborative-multicenter-studies-in-psc
#11
LETTER
Kristina I Ringe, Aristeidis Grigoriadis, Emina Halibasic, Frank Wacker, Michael P Manns, Christoph Schramm, Henrike Lenzen
Recently, the MRI working group of the International PSC Study Group (IPSCSG) has published a position statement on the use of MRI regarding diagnosis and follow-up of PSC patients. These guidelines are intended for use by physicians in daily clinical routine. In addition, the group has outlined several areas of research, which need to be addressed in the near future. As PSC is a rare disease with the clinical outcome being determined by the development of end-stage liver disease and hepatobiliary malignancy...
September 17, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30218583/validation-of-risk-score-in-predicting-early-readmissions-in-decompensated-cirrhotic-patients-a-model-based-on-the-administrative-database
#12
Khalid Mumtaz, Abdulfatah Issak, Kyle Porter, Sean Kelly, James Hanje, Anthony J Michaels, Lanla F Conteh, Ashraf El-Hinnawi, Sylvester M Black, Marwan S Abougergi
INTRODUCTION: The early readmission in patients with decompensated liver cirrhosis leads to enormous burden on healthcare utilization. METHODS: Retrospective cohort study using the 2013 and 2014 Nationwide Readmission Database (NRD) was conducted. Patients with diagnoses of cirrhosis and at least one feature of decompensation were included. The primary outcome was to develop a validated risk model for early readmission. Secondary outcomes were to study 30-day all cause-readmission rate and most common reasons for readmission...
September 15, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30218577/liver-transplantation-for-fulminant-hepatitis-due-to-yellow-fever
#13
Alice Tung Wan Song, Edson Abdala, Rodrigo Bronze de Martino, Luis Marcelo Sá Malbouisson, Ryan Yukimatsu Tanigawa, Guilherme Marques Andrade, Liliana Ducatti, Andre Mario Doi, João Renato Rebello Pinho, Michele Soares Gomes-Gouvêa, Fernanda de Mello Malta, Rubens Macedo Arantes Junior, Adriana Coracini Tonacio, Lécio Figueira Pinto, Luciana Bertocco Paiva Haddad, Vinicius Rocha Santos, Rafael Soares Nunes Pinheiro, Lucas Souto Nacif, Flávio Henrique Ferreira Galvão, Venancio Avancini Ferreira Alves, Wellington Andraus, Luiz Augusto Carneiro D'Albuquerque
A previously healthy 27-year-old female had 3 days of fever (40°C), headache, and myalgia. She had not been previously vaccinated for YF. Initial workup revealed 2,150 leukocytes/mm3 , 83,000 platelets/mm3 , AST 8462U/L and ALT 5249U/L (Figure 1). She was icteric with a heart rate of 60 bpm. The following day, a generalized seizure led to intubation, and renal failure led to hemodialysis. Transcranial doppler ultrasound showed signs of intracranial hypertension, cranial CT scan showed diffuse hypoattenuation and loss of grey-white differentiation; abdominal doppler ultrasound, and echocardiogram were normal...
September 15, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30216483/-letter-to-editor-terlipressin-is-superior-to-noradrenaline-in-the-management-of-acute-kidney-injury-in-acute-on-chronic-liver-failure
#14
LETTER
Sapana Verma, Shaleen Agarwal, Shweta Singh, Nivedita Pandey, Subhash Gupta
The article by Arora et al. (2018) compared use of two vasoconstrictors terlipressin and noradrenaline in the management of acute kidney injury in ACLF patient. Numerous other trials have shown no difference between the two when HRS occurred in decompensated cirrhosis. (1,2 ) however the authors claims that the pathophysiology of HRS in ACLF is different and therefore these two vasoconstrictors may have different outcome in this situation. This article is protected by copyright. All rights reserved.
September 14, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30215868/inflammation-and-microbiota-fingerprint-delphi-s-oracle-for-nafld-related-hcc
#15
EDITORIAL
Marco Cassano, Jean-François Dufour
Dysfunctions of the gut bacterial flora have an important impact on liver diseases. Quantitative or qualitative ruptures of intestinal homeostasis, collectively termed dysbiosis, constitute an increasingly recognized associated factor for chronic liver diseases, including non-alcoholic fatty liver disease (NAFLD). The evidence that gut maladaptation is a common feature in NAFLD settings led Ponziani et al. to investigate whether specific variations of the flora and inflammatory cues are enriched in NAFLD patients presenting with HCC (Ponziani et al...
September 14, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30215854/the-interstitial-space-takes-shape
#16
Prodromos Hytiroglou, Ian R Wanless
In March 2018, Benias et al. published a study, entitled "Structure and distribution of an unrecognized interstitium in human tissues"(1), which received extensive news coverage. The authors utilized a variety of methods, including in vivo and ex vivo confocal laser endomicroscopy, frozen and routine histologic preparations, immunohistochemistry, electron microscopy and second harmonic generation microscopy, to provide novel information on the structure and function of the interstitial space. This article is protected by copyright...
September 14, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30215850/hepatocyte-specific-%C3%AE-catenin-deletion-during-severe-liver-injury-provokes-cholangiocytes-to-differentiate-into-hepatocytes
#17
Jacquelyn O Russell, Wei-Yu Lu, Hirohisa Okabe, Marc Abrams, Michael Oertel, Minakshi Poddar, Sucha Singh, Stuart J Forbes, Satdarshan P Monga
Liver regeneration after injury is normally mediated by proliferation of hepatocytes, although recent studies have suggested biliary epithelial cells (BECs) can differentiate into hepatocytes during severe liver injury when hepatocyte proliferation is impaired. We investigated the effect of hepatocyte-specific β-catenin deletion in recovery from severe liver injury and BEC-to-hepatocyte differentiation. To induce liver injury, we administered choline-deficient, ethionine-supplemented (CDE) diet to three different mouse models, the first being mice with deletion of β-catenin in both BECs and hepatocytes (Albumin-Cre; Ctnnb1flox/flox mice)...
September 14, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30199577/reply-to-lte-hep-18-1401
#18
LETTER
Jacqueline G O'Leary, Rajander K Reddy, Florence Wong, Guadalupe Garcia-Tsao, Patrick S Kamath, Leroy R Thacker, Jasmohan S Bajaj
We thank Dr. Cardoso and colleges for their letter about our recent Hepatology paper validating the easy to use North American Consortium for the Study of End-stage Liver Disease (NACSELD) - Acute-on-Chronic (ACLF) score in 2675 prospectively enrolled patients continent wide(1). Their main concern was the possibility that patients could meet NACSELD-ACLF criteria (≥2 organ failures) by requiring intubation for airway protection during grade III/IV hepatic encephalopathy(2). This is because our simple bedside tool does not require the calculation of a PaO2 /FiO2 ratio like the more complicated CLIF-SOFA score...
September 10, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30199576/a-novel-lncrna-regulates-hcv-infection-through-ifi6
#19
Xiao Liu, Xiaoqiong Duan, Jacinta A Holmes, Wenting Li, Sae Hwan Lee, Zeng Tu, Chuanlong Zhu, Shadi Salloum, Anna Lidofsky, Esperance A Schaefer, Cai Dachuan, Shilin Li, Haoju Wang, Yongfu Huang, Yongju Zhao, Ming-Lung Yu, Zhiwen Xu, Limin Chen, Jian Hong, Wenyu Lin, Raymond T Chung
BACKGROUND AND AIMS: Long non-coding RNAs (lncRNAs) play a critical role in the regulation of many important cellular processes. However, the mechanisms by which lncRNAs regulate viral infection and host immune responses are not well understood. We sought to explore lncRNA regulation of HCV infection and interferon response. METHODS: We performed RNAseq in Huh7.5.1 cells with or without IFNα treatment. CRISPR/Cas9 guide RNA (gRNA) was used to knock out selected genes...
September 10, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30199572/acute-on-chronic-liver-failure-defined-by-nacseld-the-impact-on-prognosis-and-futility-of-care
#20
LETTER
Filipe S Cardoso
O'Leary J.G. et al. should be congratulated for their manuscript on the validation of the NACLSELD Acute-on-Chronic Liver Failure (ACLF) score for the prognostication of 30-day survival in hospitalized patients with cirrhosis [1]. The definitions of extrahepatic organ failures proposed in this score are different from its European counterpart, the CLIF-SOFA score, especially in regards to respiratory failure (RF) [2]. While O'Leary J.G. et al. defined RF as the need for bilevel positive airway pressure or mechanical ventilation, Moreau R...
September 10, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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