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Hepatology: Official Journal of the American Association for the Study of Liver Diseases

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https://www.readbyqxmd.com/read/29149457/hmgb1-controls-liver-cancer-initiation-through-yap-dependent-aerobic-glycolysis
#1
Ruochan Chen, Shan Zhu, Xue-Gong Fan, Haichao Wang, Michael T Lotze, Herbert J Zeh, Timothy R Billiar, Rui Kang, Daolin Tang
Emerging studies have suggested that the Hippo pathway is involved in the tumorigenesis of hepatocellular carcinoma (HCC). However, the key regulator of the Hippo pathway in liver tumor metabolic reprogramming remains elusive. Here, we provide evidence to support that high mobility group box 1 (HMGB1), a chromosomal protein, plays a role in the regulation of the Hippo pathway during liver tumorigenesis. Cre/loxP recombination-mediated HMGB1 depletion in hepatocytes blocks diethylnitrosamine-induced liver cancer initiation in mice, whereas shRNA-mediated gene silencing of HMGB1 inhibits HCC cell proliferation...
November 17, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29144556/exercise-alters-the-hepatic-immunophenotype-to-protect-against-inflammatory-liver-disease
#2
Abhishek Chauhan, David H Adams
No abstract text is available yet for this article.
November 16, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29144555/-chop-ing-intestinal-stem-cells-on-way-to-cholestatic-liver-injury
#3
EDITORIAL
Akanksha Sharma, Chandrashekhar R Gandhi
No abstract text is available yet for this article.
November 16, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29140564/%C3%AE-catenin-and-il-1%C3%AE-dependent-cxcl10-production-drives-progression-of-disease-in-a-mouse-model-of-congenital-hepatic-fibrosis
#4
Eleanna Kaffe, Romina Fiorotto, Francesca Pellegrino, Valeria Mariotti, Mariangela Amenduni, Massimiliano Cadamuro, Luca Fabris, Mario Strazzabosco, Carlo Spirli
Congenital Hepatic Fibrosis (CHF), a genetic disease caused by mutations in the PKHD1 gene, encoding for the protein fibrocystin (FPC), is characterized by biliary dysgenesis, progressive portal fibrosis, and by a PKA-mediated activating phosphorylation of β-Catenin at Ser675. Biliary structures of Pkhd1(del4/del4) mice, a mouse model of CHF, secrete CXCL10 a chemokine able to recruit macrophages. The aim of this study is to clarify whether CXCL10 plays a pathogenetic role in disease progression in CHF/CD and to understand the mechanisms leading to increased CXCL10 secretion...
November 15, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29140550/lncrna-h19-interacts-with-polypyrimidine-tract-binding-protein-1-to-reprogram-hepatic-lipid-homeostasis
#5
Chune Liu, Zhihong Yang, Jianguo Wu, Li Zhang, Sangmin Lee, Dong-Ju Shin, Melanie Tran, Li Wang
H19 is an imprinted long non-coding RNA abundantly expressed in embryonic liver and repressed after birth. Here we show that H19 serves as a lipid sensor by synergizing with RNA-binding protein PTBP1 to modulate hepatic metabolic homeostasis. H19RNA interacts with PTBP1 to facilitate its association with SREBP1c mRNA and protein, leading to increased stability and nuclear transcriptional activity. H19 and PTBP1 are upregulated by fatty acids in hepatocytes and in diet-induced fatty liver, which further augments lipid accumulation...
November 15, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29140542/perioperative-von-willebrand-factor-dynamics-are-associated-with-liver-regeneration-and-predict-outcome-after-liver-resection
#6
Patrick Starlinger, David Pereyra, Stefanie Haegele, Paul Braeuer, Lukas Oehlberger, Florian Primavesi, Andreas Kohler, Florian Offensperger, Thomas Reiberger, Arnulf Ferlitsch, Barbara Messner, Guido Beldi, Stefan Staettner, Christine Brostjan, Thomas Gruenberger
Von Willebrand Factor (vWF) was found to mediate platelet influx during the early phase of liver regeneration in mice. Further, increased vWF-antigen (vWF-Ag) levels were shown to be predictive for outcome of patients with chronic liver disease. Accordingly, we aimed to assess the relevance of perioperative vWF-Ag dynamics in terms of liver regeneration and clinical outcome in patients undergoing liver resection (LR). Accordingly, we observed that vWF-Ag and its activity - estimated via ristocetin cofactor measurement - increased immediately after induction of liver regeneration and was associated with platelet accumulation within the liver...
November 15, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29140540/microrevolution-in-understanding-primary-biliary-cholangitis-pathophysiology
#7
EDITORIAL
Marta B Afonso, Cecília M P Rodrigues
No abstract text is available yet for this article.
November 15, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29140538/is-liver-transplantation-for-intractable-attacks-of-porphyria-a-viable-treatment-in-a-developing-country
#8
LETTER
Daniel A Jaramillo-Calle, Omar Castaño Quintero, Juan-Ignacio Marín, Alicia M Cock-Rada, Oscar Santos Sánchez, Octavio Muñoz, Juan-Carlos Restrepo
No abstract text is available yet for this article.
November 15, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29119610/association-of-vitamin-e-intake-at-early-childhood-with-alanine-aminotransferase-levels-at-mid-childhood
#9
Jennifer A Woo Baidal, Erika R Cheng, Sheryl L Rifas-Shiman, Emily Oken, Matthew W Gillman, Elsie M Taveras
The extent to which vitamin E (alpha-tocopherol) intake early in childhood is associated with alanine aminotransferase (ALT) level later in childhood is unknown. The objective of this research is to test the hypothesis that higher alpha-tocopherol intake during early childhood is associated with lower odds of elevated ALT levels during mid-childhood, and to examine how body mass index (BMI) influences these relationships. We studied 528 children in Project Viva. Mothers reported child dietary intake at early childhood visits (median 3...
November 9, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29116649/wwc-proteins-regulate-hepatic-cell-differentiation-and-tumorigenesis-via-the-hippo-signaling-pathway
#10
Anke Hermann, Dirk Oliver Wennmann, Sascha Gromnitza, Maria Edeling, Veerle Van Marck, Marius Sudol, Liliana Schaefer, Kerstin Duning, Thomas Weide, Hermann Pavenstädt, Joachim Kremerskothen
The Hippo pathway regulates cell differentiation, proliferation and apoptosis. Upon activation, it inhibits the import of the transcriptional co-activator YAP into the nucleus, thus suppressing transcription of pro-proliferative genes. Hence, dynamic and precise control of the Hippo pathway is crucial for organ size control and the prevention of tumor formation. Hippo signaling is controlled by a growing number of upstream regulators - including WWC proteins - which trigger a serine/threonine kinase pathway...
November 8, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29113028/restoration-of-a-healthy-intestinal-microbiota-normalizes-portal-hypertension-in-a-rat-model-of-nonalcoholic-steatohepatitis
#11
Teresa García-Lezana, Imma Raurell, Miren Bravo, Manuel Torres-Arauz, María Teresa Salcedo, Alba Santiago, Andreu Schoenenberger, Chaysavanh Manichanh, Joan Genescà, María Martell, Salvador Augustin
Portal hypertension (PH) drives most of the clinical complications in chronic liver diseases. However, its progression in nonalcoholic steatohepatitis (NASH) and its association with the intestinal microbiota (IM) has been scarcely studied. Our aim was to investigate the role of IM in the mechanisms leading to PH in early NASH. The experimental design was divided in two stages: Stage 1: Sprague-Dawley rats were fed for 8 weeks with high-fat diet and high-glucose/fructose syrup (HFGFD) or control diet/water (CD)...
November 7, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29108133/targeted-delivery-of-mir-199a-3p-using-self-assembled-dipeptide-nanoparticles-efficiently-reduces-hepatocellular-carcinoma
#12
Aditi Varshney, Jiban J Panda, Avishek K Singh, Nitin Yadav, Chhagan Bihari, Subhrajit Biswas, Shiv K Sarin, Virander S Chauhan
Hepatocellular carcinoma (HCC) is an aggressive tumor with limited systemic and locoregional modalities of treatment. Although microRNA (miRNA) based therapies have significant potential, their targeted delivery remains a major challenge. miR-199a-3p functions as an important tumor suppressor in HCC, which regulates various cellular processes. Recently, peptide-based nanoparticles (NPs) have been developed to deliver oligonucleotides including miRNA. Here, we describe the synthesis and characterization of arginine α,β-dehydrophenylalanine (RΔF) nanoparticles for the selective delivery of miR-199a-3p to restore dysregulated gene expression in HCC...
November 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29108132/incidence-and-predictors-of-hbsag-seroclearance-after-cessation-of-nucleos-t-ide-analogue-therapy-in-hbeag-negative-chronic-hepatitis-b
#13
Wen-Juei Jeng, Yi-Cheng Chen, Rong-Nan Chien, I-Shyan Sheen, Yun-Fan Liaw
Hepatitis B s antigen (HBsAg) loss is a rare event during nucleos(t)ide analogue (Nuc) therapy. Limited data suggest that stopping Nuc therapy may increase HBsAg loss rate in hepatitis B e antigen (HBeAg) negative patients. A large study was conducted to investigate this issue in more detail. Of the 1075 HBeAg-negative patients treated with Nuc for 156 (61-430) weeks, 6 showed HBsAg seroclearance during treatment at an estimated annual incidence of 0.15%. Of the patients who remained HBsAg seropositive, 691 (52...
November 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29108123/optimal-threshold-of-controlled-attenuation-parameter-with-mri-pdff-as-the-gold-standard-for-the-detection-of-hepatic-steatosis
#14
Cyrielle Caussy, Mosab H Alquiraish, Phirum Nguyen, Carolyn Hernandez, Sandra Cepin, Lynda E Fortney, Veeral Ajmera, Ricki Bettencourt, Summer Collier, Jonathan Hooker, Ethan Sy, Emily Rizo, Lisa Richards, Claude B Sirlin, Rohit Loomba
The optimal threshold of controlled attenuation parameter (CAP) for the detection of hepatic steatosis using both M and XL probe is unknown in nonalcoholic fatty liver disease (NAFLD). Magnetic resonance imaging proton-density-fat-fraction (MRI-PDFF) is an accurate and precise method to detect presence of hepatic steatosis and is better than CAP. Thus, the aim of this study was to evaluate the diagnostic accuracy and the optimal threshold of CAP for the detection of hepatic steatosis as defined by MRI-PDFF ≥ 5%...
November 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29108122/pyroptosis-by-caspase11-4-gasdermin-d-pathway-in-alcoholic-hepatitis
#15
Elena Khanova, Raymond Wu, Wen Wang, Rui Yan, Yibu Chen, Samuel W French, Cristina Llorente, Stephanie Q Pan, Qihong Yang, Yuchang Li, Raul Lazaro, Charles Ansong, Richard D Smith, Ramon Bataller, Timothy Morgan, Bernd Schnabl, Hidekazu Tsukamoto
Alcoholic hepatitis (AH) continues to be a disease with high mortality and no efficacious medical treatment. Although severe AH is presented as acute on chronic liver failure, what underlies this transition from chronic alcoholic steatohepatitis (ASH) to AH, is largely unknown. To address this question, unbiased RNA-seq and proteomic analyses were performed on livers of the recently developed AH mouse model which exhibits the shift to AH from chronic ASH upon weekly alcohol binge, and these results are compared with gene expression profiling data from AH patients...
November 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29108121/hepatitis-c-and-human-immunodeficiency-virus-co-infection-in-the-era-of-direct-acting-antiviral-agents-no-longer-a-difficult-to-treat-population
#16
Cameron Sikavi, Phillip H Chen, Alex D Lee, Elena G Saab, Gina Choi, Sammy Saab
BACKGROUND: The treatment of chronic hepatitis C (HCV) in human immunodeficiency virus 1 (HIV) infected individuals has been historically marked by low sustained virologic response (SVR) rates in comparison to those without HIV infection, resulting in the Food and Drug Administration (FDA) labeling those coinfected as a "special population with an unmet medical need." OBJECTIVES: We systematically reviewed the treatment of chronic HCV infection in those infected with HIV...
November 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29108120/reply-to-should-venous-ammonia-be-used-in-decision-making-acute-liver-failure-patients
#17
LETTER
Filipe S Cardoso, Michelle Gottfried, Shannan Tujios, Jody C Olson, Constantine J Karvellas
No abstract text is available yet for this article.
November 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29108118/should-venous-ammonia-be-used-in-decision-making-acute-liver-failure-patients
#18
LETTER
Chetan Kalal, Akash Shukla, Ravi Mohanka, Samir Shah
No abstract text is available yet for this article.
November 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29108117/don-t-forget-the-general-practitioner
#19
LETTER
Michael Patrick Johnston, Iona Campbell, Judith Morris, Fiona Finlay
No abstract text is available yet for this article.
November 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29105109/letter-to-the-editors-cystic-fibrosis-liver-disease-in-adults-limits-of-non-invasive-tests-of-fibrosis
#20
LETTER
S Hillaire, D Cazals-Hatem, S Erlinger, V Paradis
No abstract text is available yet for this article.
November 3, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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