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Hepatology: Official Journal of the American Association for the Study of Liver Diseases

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https://www.readbyqxmd.com/read/30004129/harnessing-the-integrated-stress-response-to-counteract-metabolic-disease
#1
EDITORIAL
Anne S Henkel
Over a decade ago, fibroblast growth factor 21 (FGF21) was identified as a novel regulator of metabolism (1). Since that time, accumulating data have substantiated the therapeutic potential of this hormone in counteracting metabolic disease. Increasing levels of FGF21 in mice, either through transgenic overexpression or exogenous administration, has consistently produced favorable effects on obesity and its sequelae. Mechanistically, FGF21 has been shown to promote browning of adipose tissue, increase thermogenesis, and enhance energy expenditure...
July 13, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29907965/the-genetic-architecture-of-diet-induced-hepatic-fibrosis-in-mice
#2
Simon T Hui, Zeyneb Kurt, Iina Tuominen, Frode Norheim, Richard C Davis, Calvin Pan, Darwin L Dirks, Clara E Magyar, Samuel W French, Karthickeyan Chella Krishnan, Simon Sabir, Francisco Campos-Pérez, Nahum Méndez-Sánchez, Luis Macías-Kauffer, Paola León-Mimila, Samuel Canizales-Quinteros, Xia Yang, Simon W Beaven, Adriana Huertas-Vazquez, Aldons J Lusis
We report the genetic analysis of a "humanized" hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis. Mice carrying transgenes for human APOE*3-Leiden and CETP and fed a "Western" diet were studied on the genetic backgrounds of over 100 inbred mouse strains. The mice developed hepatic inflammation and fibrosis that was highly dependent on genetic background, with vast differences in the degree of fibrosis. Histological analysis showed features characteristic of human NASH, including macrovesicular steatosis, hepatocellular ballooning, inflammatory foci and pericellular collagen deposition...
June 16, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29901219/the-use-of-steroid-for-transcatheter-arterial-chemoembolization-to-relieve-symptoms-or-to-mask-adverse-events
#3
LETTER
Gin-Ho Lo
No abstract text is available yet for this article.
June 14, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29901217/reply
#4
LETTER
Tetsuhiro Chiba
No abstract text is available yet for this article.
June 14, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29893492/a-novel-association-between-core-mutations-in-hepatitis-b-virus-genotype-f1b-and-hepatocellular-carcinoma-in-alaskan-native-people
#5
Sanae Hayashi, Anis Khan, Brenna C Simons, Chriss Homan, Takeshi Matsui, Kenji Ogawa, Keigo Kawashima, Shuko Murakami, Satoru Takahashi, Masanori Isogawa, Kazuho Ikeo, Masashi Mizokami, Brian J McMahon, Yasuhito Tanaka
Hepatitis B virus (HBV) genotype F1b infection is strongly associated with hepatocellular carcinoma (HCC) in young Alaskan Native (AN) people. However, the mechanisms by which genotype F1b causes HCC are unclear. Here, we analyzed the clinical and virological significance of genotype F1b in long-term serial samples from 20 HCC patients with HBV infection. Complete sequence analyses revealed that all isolates were genotype F1b. In the HCC patients, T1938C and A2051C mutations in the core region had accumulated significantly with A1762T/G1764A mutations in the basal core promoter (BCP) region and G1896A mutation in the precore (PC) region...
June 12, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29888801/tcpobop-induced-hepatomegaly-hepatocyte-proliferation-is-attenuated-by-combined-disruption-of-met-egfr-signaling
#6
Bharat Bhushan, John W Stoops, Wendy M Mars, Anne Orr, William C Bowen, Shirish Paranjpe, George K Michalopoulos
TCPOBOP (1,4-Bis [2-(3,5-Dichloropyridyloxy)] benzene) is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss. TCPOBOP-induced direct hyperplasia has been considered to be CAR-dependent with no evidence of involvement of cytokines or growth factor signaling. Receptor tyrosine kinases (RTKs), MET and EGFR, are known to play a critical role in liver regeneration after partial hepatectomy, but their role in TCPOBOP-induced direct hyperplasia, not yet explored, is investigated in the current study...
June 11, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29888798/letter-to-editor-association-of-non-alcoholic-fatty-liver-disease-with-relative-skeletal-muscle-mass-a-public-health-perspective
#7
LETTER
Saumya Pandey
No abstract text is available yet for this article.
June 11, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29888797/transplantation-of-livers-from-viremic-hcv-positive-donors-into-hcv-negative-recipients
#8
LETTER
Paulo N Martins
No abstract text is available yet for this article.
June 11, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29888796/stereotactic-body-radiation-therapy-induced-abscopal-effect-on-hepatocellular-carcinoma-after-treatment-for-lung-cancer-a-case-report
#9
Fumiko Chino, Kimberly Ellen Pollis, Steve Choi, Joseph K Salama, Manisha Palta
No abstract text is available yet for this article.
June 11, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29888786/upper-gi-bleeding-in-cirrhotic-patients-which-method-to-search-for-helicobacter-pylori-infection
#10
LETTER
Rinaldo Pellicano, Marilena Durazzo
No abstract text is available yet for this article.
June 11, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29790592/hepatitis-b-virus-upregulated-lnc-hur1-promotes-cell-proliferation-and-tumorigenesis-by-blocking-p53-activity
#11
Ningning Liu, Qi Liu, Xiaohai Yang, Fang Zhang, Xinda Li, Yuanwu Ma, Feifei Guan, Xin Zhao, Zhiwei Li, Lianfeng Zhang, Xin Ye
Recent studies have indicated that a number of lncRNAs are dysregulated in hepatocellular carcinoma, while their aberrant expressions are associated with tumorigenesis and poor prognosis. To identify HBV-related lncRNAs, we used RNA deep sequencing to quantify the abundances of lncRNAs in HepG2 cells and HBV transgenic HepG2-4D14 cells. Here, we demonstrate that lnc-HUR1 is significantly upregulated in HepG2-4D14 cells. We found that HBV-encoded HBx can enhance the transcription of lnc-HUR1. Overexpression of lnc-HUR1 promotes cell proliferation, while knockdown of lnc-HUR1 inhibits cell growth...
May 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29790588/the-lncrna-casc9-and-rna-binding-protein-hnrnpl-form-a-complex-and-co-regulate-genes-linked-to-akt-signaling
#12
Marcel Klingenberg, Matthias Groß, Ashish Goyal, Maria Polycarpou-Schwarz, Thilo Miersch, Anne-Sophie Ernst, Jörg Leupold, Nitin Patil, Uwe Warnken, Heike Allgayer, Thomas Longerich, Peter Schirmacher, Michael Boutros, Sven Diederichs
The identification of viability-associated long non-coding RNAs (lncRNA) might be a promising rationale for new therapeutic approaches in liver cancer. Here, we applied the first RNAi screening approach in hepatocellular carcinoma (HCC) cell lines to find viability-associated lncRNAs. Among the multiple identified lncRNAs with a significant impact on HCC cell viability, we selected CASC9 (Cancer Susceptibility 9) due to the strength of its phenotype, expression, and upregulation in HCC versus normal liver. CASC9 regulated viability across multiple HCC cell lines as shown by CRISPR interference, single siRNA- and siPOOL-mediated depletion of CASC9...
May 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29790582/acetyl-coa-carboxylase-inhibition-reverses-nafld-and-hepatic-insulin-resistance-but-promotes-hypertriglyceridemia-in-rodents
#13
Leigh Goedeke, Jamie Bates, Daniel F Vatner, Rachel J Perry, Ting Wang, Ricardo Ramirez, Li Li, Matthew W Ellis, Dongyan Zhang, Kari E Wong, Carine Beysen, Gary W Cline, Adrian S Ray, Gerald I Shulman
Pharmacologic inhibition of acetyl-CoA carboxylase (ACC) enzymes, ACC1 and ACC2, offers an attractive therapeutic strategy for non-alcoholic fatty liver disease (NAFLD) via simultaneous inhibition of fatty acid synthesis and stimulation of fatty acid oxidation. However, the effects of ACC inhibition on hepatic mitochondrial oxidation, anaplerosis, and ketogenesis in vivo are unknown. Here, we evaluated the impact of a novel liver-directed allosteric inhibitor of ACC1 and ACC2 (Compound 1) on these parameters, as well as glucose and lipid metabolism, in control and diet-induced rodent models of NAFLD...
May 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29790196/rituximab-is-ineffective-for-treatment-of-fatigue-in-primary-biliary-cholangitis-a-phase-2-randomised-controlled-trial
#14
Amardeep Khanna, Laura Jopson, Denise Howel, Andrew Bryant, Andrew Blamire, Julia L Newton, David E Jones
Primary Biliary Cholangitis (PBC) is a chronic cholestatic liver disease. Half of patients experience debilitating fatigue which is currently untreatable. Previous studies have shown muscle bioenergetic abnormalities in PBC, including increased muscle acidosis with exercise linked to the anti-mitochondrial antibody (AMA) diagnostic of the disease, and reduced anaerobic threshold. In this study we addressed the hypothesis that fatigue in PBC is driven by muscle bioenergetic abnormality related to AMA, and that AMA reduction with B-cell depletion therapy will improve fatigue...
May 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29790191/pay-it-forward-building-capacity-to-treat-hepatitis-c-by-training-our-own-residents
#15
Thomas Couri, Tanmayi Gupta, George Weyer, Andrew Aronsohn
No abstract text is available yet for this article.
May 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29790188/coagulation-failure-in-patients-with-acute-on-chronic-liver-failure-aclf-and-decompensated-cirrhosis-beyond-inr
#16
Annabel Blasi, Andrea Calvo, Verónica Prado, Enric Reverter, Juan Carlos Reverter, María Hernández-Tejero, Fátima Aziz, Alex Amoros, Andres Cardenas, Javier Fernández
Balanced hemostasis with hypo and hypercoagulable features may occur in acute-on-chronic liver failure. Characteristics and prognostic impact of the coagulation profile in acute-on-chronic liver failure are unknown. METHODS: Consecutive patients with acute-on-chronic liver failure (n=36) and acute decompensation (n=24) were included. Blood samples for thromboelastometry (ROTEM®) were obtained at admission and 72h thereafter. Coagulation profile was evaluated in patients with and without acute-on-chronic liver failure and in those with and without systemic inflammatory response syndrome...
May 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29790184/fat10-overexpression-disturbs-wisp1-protein-and-mrna-expression-to-promote-hepatocellular-carcinoma-progression
#17
Jinlong Yan, Jun Lei, Leifeng Chen, Huan Deng, Dingxiang Dong, Tao Jin, Xiuxia Liu, Rongfa Yuan, Yumin Qiu, Jin Ge, Xiaogang Peng, Jianghua Shao
Recently, studies on transcriptome-proteome relationships have revealed mRNA/protein expression discordance for certain genes and speculated that protein post-translational modification (PTM) may be involved. However, there is currently no evidence to support this hypothesis. Wnt-induced secreted protein-1 (WISP1) is the downstream target gene of β-catenin and plays an important role in tumorigenesis and progression, but the expression and role of WISP1 in different tumor types are controversial. Here, we first confirmed WISP1 protein expression was significantly downregulated in hepatocellular carcinoma (HCC) tissue, and could be an independent predictor of poor prognosis for patients with HCC...
May 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29790183/fasting-inhibits-the-recruitment-of-kinesin-1-to-lipid-droplets-and-stalls-hepatic-triglyceride-secretion
#18
Ryan J Schulze, Mark A McNiven
No abstract text is available yet for this article.
May 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29774589/healthcare-cost-and-utilization-in-nonalcoholic-fatty-liver-disease-real-world-data-from-a-large-us-claims-database
#19
Alina M Allen, Holly K Van Houten, Lindsey R Sangaralingham, Jayant A Talwalkar, Rozalina G McCoy
The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing. The health care burden resulting from the multidisciplinary management of this complex disease is unknown. We assessed the total health care cost and resource utilization associated with a new NAFLD diagnosis, compared to controls with similar comorbidities. We used OptumLabs Data Warehouse, a large national administrative claims database with longitudinal health data of over 100 million individuals enrolled in private and Medicare Advantage health plans...
May 18, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29774579/integrative-epigenetic-analysis-reveals-therapeutic-targets-to-the-dna-methyltransferase-inhibitor-sgi-110-in-hepatocellular-carcinoma
#20
Minmin Liu, Lian Zhang, Hongtao Li, Toshinori Hinoue, Wanding Zhou, Hitoshi Ohtani, Anthony El-Khoueiry, John Daniels, Casey O'Connell, Tanya B Dorff, Qianjin Lu, Daniel J Weisenberger, Gangning Liang
There is an urgent need for developing more effective therapies for hepatocellular carcinoma (HCC) because of its aggressiveness. Guadecitabine (SGI-110) is a second-generation DNA methyltransferase inhibitor (DNMTi) currently in clinical trials for HCC and shows greater stability and performance over first generation DNMTis. In order to identify potential therapeutic targets of SGI-110 for clinical trials, HCC cell lines (SNU398, HepG2 and SNU475) were used to evaluate effects of transient SGI-110 treatment by an integrative analysis of DNA methylation, nucleosome accessibility, gene expression profiles and its clinical relevance by comparisons to TCGA HCC clinical data...
May 18, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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