journal
MENU ▼
Read by QxMD icon Read
search

Behavioral Neuroscience

journal
https://www.readbyqxmd.com/read/30160507/acetaminophen-disrupts-memory-in-object-recognition-and-increases-extracellular-signal-regulated-kinase-phosphorylation-in-male-mice
#1
Tyler M Milewski, Patrick T Orr
Acetaminophen (also known as paracetamol) is a commonly used over-the-counter pain medication, but recent evidence suggests that a single exposure or prenatal exposure may have significant behavioral effects. This investigation aimed to determine whether acetaminophen could disrupt memory formation in an object-recognition task and to quantify potential changes in memory-related signaling cascades in the hippocampus of mice after acetaminophen administration. Using male mice, we examined the effect of a single subcutaneous injection of acetaminophen on the object-recognition task, a single-trial, hippocampus-dependent memory task...
August 30, 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/30160506/heterogeneity-in-human-retrosplenial-cortex-a-review-of-function-and-connectivity
#2
Elizabeth R Chrastil
Retrosplenial cortex (RSC) is an important information hub in the brain and several mental disorders demonstrate RSC dysfunction, but its role is still largely unclear. Although researchers in many cognitive domains have recognized the importance of RSC, a broader synthesis of RSC function across cognitive domains is lacking. This review examines human RSC function across several cognitive domains, considering both specific cognitive functions and the RSC subregions in which that function occurs. Overall, this review found evidence for a functional gradient across the anterior-posterior axis of RSC involving several cognitive domains...
August 30, 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/30160505/lasting-impact-on-memory-of-midlife-exposure-to-exogenous-and-endogenous-estrogens
#3
Katelyn L Black, Nina E Baumgartner, Jill M Daniel
We previously demonstrated that 40 days of prior midlife estradiol treatment results in enhanced spatial memory in aging ovariectomized rats long after termination of the estradiol treatment. Our current goal was to determine whether this benefit is due to lasting impacts on memory specifically of previous exogenous estradiol treatment or simply due to delaying cognitive deficits that occur following loss of ovarian hormones. Middle-aged rats were ovariectomized or underwent sham surgery. Ovariectomized rats received estradiol (Previous Estradiol) or vehicle (Previous Vehicle) implants...
August 30, 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/30091619/the-retrosplenial-parietal-network-and-reference-frame-coordination-for-spatial-navigation
#4
Benjamin J Clark, Christine M Simmons, Laura E Berkowitz, Aaron A Wilber
The retrosplenial cortex is anatomically positioned to integrate sensory, motor, and visual information and is thought to have an important role in processing spatial information and guiding behavior through complex environments. Anatomical and theoretical work has argued that the retrosplenial cortex participates in spatial behavior in concert with input from the parietal cortex. Although the nature of these interactions is unknown, a central position is that the functional connectivity is hierarchical with egocentric spatial information processed in the parietal cortex and higher-level allocentric mappings generated in the retrosplenial cortex...
August 9, 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/30070554/neurophysiological-signatures-of-temporal-coordination-between-retrosplenial-cortex-and-the-hippocampal-formation
#5
Andrew S Alexander, Lara M Rangel, David Tingley, Douglas A Nitz
Retrosplenial cortex (RSC) is heavily interconnected with a multitude of cortical regions and is directly connected with the hippocampal formation. As such, it is a likely coordinator of information transfer between the hippocampus (HPC) and cortex in the service of spatial cognition and episodic memory. The current work examined three potential temporal frameworks for retrosplenial-hippocampal communication, namely, theta frequency oscillations (6-12 Hz), sharp-wave/ripple events, and repeating, theta phase-locked shifts from low (30-65 Hz) to high (120-160 Hz) gamma frequency oscillations...
August 2, 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/30070553/the-retrosplenial-cortical-role-in-encoding-behaviorally-significant-cues
#6
David M Smith, Adam M P Miller, Lindsey C Vedder
The retrosplenial cortex (RSC) has recently begun to gain widespread interest because of its anatomical connectivity with other well-known memory structures, such as the hippocampus and anterior thalamus, and its role in spatial, contextual, and episodic memory. Although much of the current work on the RSC is focused on spatial cognition, there is also an extensive literature that shows that the RSC plays a critical role in a variety of conditioning tasks that have no obvious spatial component. Many of these studies suggest that the RSC is involved in identifying and encoding behaviorally significant cues, particularly those cues that predict reinforcement or the need for a behavioral response...
August 2, 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29985008/inactivation-of-the-cerebellar-fastigial-nuclei-alters-social-behavior-in-the-rat
#7
Vienna K Behnke, Morgan E Stevenson, Rodney A Swain
Research has implicated the deep cerebellar nuclei in autism. This study questioned whether fastigial nuclei abnormalities account for some of the irregular social behaviors seen in autism. Bilateral cannulation surgery was performed on 13 rats. An ABABAB reversal design was implemented. All animals received a microinfusion of saline during the baseline (A) phases. The experimental animal was placed in an open field with an unfamiliar confederate animal, and social interactions between the two animals were measured for 10 min...
July 9, 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29985009/n-acetylcysteine-blocks-serotonin-1b-agonist-induced-ocd-related-behavior-in-mice
#8
Emily M Allen, Elizabeth F Hughes, Carl J Anderson, Nancy S Woehrle
Glutamate-modulating agents are of increasing interest in obsessive-compulsive disorder (OCD). Current pharmacotherapies for OCD target the serotonin and dopamine systems, and are limited in efficacy. N-acetylcysteine (NAC) is an over-the-counter amino acid supplement that inhibits glutamate neurotransmission and has been shown in preliminary studies to reduce symptoms in OCD and related compulsive disorders. Despite growing interest in NAC as a novel psychiatric medication, no studies currently exist examining the effects of NAC in animal models of compulsive disorders...
August 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29985007/noradrenergic-receptor-modulation-influences-the-acoustic-parameters-of-pro-social-rat-ultrasonic-vocalizations
#9
Laura M Grant, Kelsey J Barth, Cagla Muslu, Cynthia A Kelm-Nelson, Vaishali P Bakshi, Michelle R Ciucci
Rats produce high rates of ultrasonic vocalizations (USVs) in social situations; these vocalizations are influenced by multiple neurotransmitter systems. Norepinephrine (NE) plays a significant role in vocalization biology; however, the contribution of NE to normal, prosocial vocal control has not been well established in the rat. To address this, we used NE adrenoceptor agonists (Cirazoline, Clonidine) and antagonists (Prozasin, Atipamezole, Propranolol) to quantify the contribution of specific alpha-1, alpha-2, and beta NE receptors to USV parameters in male Long Evans rats during seminaturalistic calling...
August 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29975080/chronic-nicotine-exposure-in-preadolescence-enhances-later-spontaneous-recovery-of-fear-memory
#10
Dana Zeid, Thomas J Gould
Preadolescent mice have been shown to be differentially susceptible to the effects of both acute and chronic nicotine exposure on contextual fear learning relative to adults. For this study, we tested the effects of chronic nicotine exposure in preadolescence on adulthood extinction and spontaneous recovery of fear memory in a model in which contextual fear acquisition occurred prior to nicotine exposure. Preadolescent (postnatal day 23) and adult (postnatal day 53) male C57BL/6J mice underwent contextual fear conditioning and were then exposed to chronic nicotine at 12...
August 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29952608/effects-of-light-at-night-on-laboratory-animals-and-research-outcomes
#11
Kathryn M Emmer, Kathryn L G Russart, William H Walker, Randy J Nelson, A Courtney DeVries
Light has substantial influences on the physiology and behavior of most laboratory animals. As such, lighting conditions within animal rooms are potentially significant and often underappreciated variables within experiments. Disruption of the light/dark cycle, primarily by exposing animals to light at night (LAN), disturbs biological rhythms and has widespread physiological consequences because of mechanisms such as melatonin suppression, sympathetic stimulation, and altered circadian clock gene expression...
August 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29952607/pigeons-consistently-prefer-easy-over-harder-access-to-food-no-reversal-after-direct-dopaminergic-stimulation
#12
Patrick Anselme, Tim Dreher, Onur Güntürkün
Many studies show that animals may prefer earned over free food-a phenomenon referred to as "contrafreeloading." In rodents, dopamine-which is involved in incentive motivation and effort-facilitates the occurrence of such a preference. Here, we investigated the behavioral effects of pramipexole (PPX), a dopamine D2/3 receptor agonist, on contrafreeloading in pigeons. In Experiment 1, 2 groups of pigeons (PPX and SAL) were simultaneously exposed to a bowl that contained grains only (easy food option) and a bowl that contained grains covered with sawdust (harder food option) for 6 sessions...
August 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29952606/estradiol-treatment-in-a-nonhuman-primate-model-of-menopause-preserves-affective-reactivity
#13
Eliza Bliss-Moreau, Mark G Baxter
Human affective life changes with age, becoming more positive and less negative in later life. This change occurs even as aging leads to declines in health and cognitive outcomes. Despite these well-documented effects in humans, the extent to which affective processes change as a result of aging in nonhuman animals, particularly nonhuman primates, is unclear. As a first step toward developing an animal model for human affective aging, we tested aged, surgically menopausal aged and middle-aged gonadally intact female rhesus monkeys (Macaca mulatta) on a classic index of affective reactivity in monkeys, the Human Intruder Task...
August 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29952605/orexin-neurons-couple-neural-systems-mediating-fluid-balance-with-motivation-related-circuits
#14
Seth W Hurley, Heather A Arseth, Alan Kim Johnson
During extracellular dehydration, neural systems that sense deficits in body fluid homeostasis operate in tandem with those that mediate motivation and reward in order to promote ingestive behaviors that restore fluid balance. We hypothesized that hypothalamic orexin (Ox) neurons act as an interface to couple brain regions sensing and processing information about body fluid status with central nervous system motivation and reward systems. An initial set of anterograde and retrograde tracing experiments suggested that structures along the lamina terminalis (LT), a region of the forebrain that serves to monitor and integrate information reflecting body fluid balance, project to hypothalamic Ox neurons that, in turn, project to dopamine neurons in the ventral tegmental area (VTA)...
August 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29952604/timing-of-cyclic-estradiol-treatment-differentially-affects-cognition-in-aged-female-rhesus-monkeys
#15
Mark G Baxter, Anthony C Santistevan, Eliza Bliss-Moreau, John H Morrison
Some evidence suggests that there may be a limited "window of opportunity" for beneficial effects of hormone therapy after menopause in women. We tested whether the timing of cyclic estradiol (E2) treatment impacted its effect on cognitive function in aged, surgically menopausal (ovariectomized) rhesus monkeys. Monkeys were assigned to one of four treatment conditions after ovariectomy: either vehicle or E2 treatment for the duration of the protocol, vehicle for the first 2 years of the protocol followed by E2 for the remainder (delayed treatment), or E2 for the first 11 months of the protocol followed by vehicle for the remainder (withdrawn treatment)...
August 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29878805/preventing-the-return-of-fear-memories-with-postretrieval-extinction-a-human-study-using-a-burst-of-white-noise-as-an-aversive-stimulus
#16
Jose Fernandez-Rey, Daniel Gonzalez-Gonzalez, Jaime Redondo
Standard extinction procedures seem to imply an inhibition of the fear response, but not a modification of the original fear-memory trace, which remains intact (Bouton, 2002, 2004). Typically, the behavioral procedure used to modify this trace is the so-called postretrieval extinction, consisting of fear-memory reactivation followed by extinction applied within the reconsolidation window. However, the application of this technique yields mixed results, probably due to a series of boundary conditions that limit the effectiveness of postretrieval-extinction effects...
August 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29781628/early-life-stress-impairs-contextual-threat-expression-in-female-but-not-male-mice
#17
Gabriela Manzano-Nieves, Mizan Gaillard, Meghan Gallo, Kevin G Bath
Early life stress (ELS) is associated with altered processing of threat signals, and increased lifetime risk of anxiety and affective pathology, disorders that disproportionately affect females. We tested the impact of a limited bedding paradigm of ELS (from P4-11) on contextual threat learning, context memory, footshock sensitivity, and anxietylike behavior, in adult male and female mice. To examine contextual threat learning, mice conditioned by context/footshock association were tested 24 hr later for the context memory...
August 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29878804/role-of-retrosplenial-cortex-in-processing-stress-related-context-memories
#18
Kevin A Corcoran, Naoki Yamawaki, Katherine Leaderbrand, Jelena Radulovic
This work summarizes evidence for the role of RSC in processing fear-inducing context memories. Specifically, we discuss molecular, cellular, and network mechanisms by which RSC might contribute the processing of contextual fear memories. We focus on glutamatergic and cholinergic mechanisms underlying encoding, retrieval, and extinction of context-dependent fear. RSC mechanisms underlying retrieval of recently and remotely acquired memories are compared to memory mechanisms of anterior cortices. Due to the strong connectivity between hippocampus and RSC, we also compare the extent to which their mechanisms of encoding, retrieval, and extinction show overlap...
June 7, 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29863372/retrosplenial-cortex-has-a-time-dependent-role-in-memory-for-visual-stimuli
#19
Matthew Y Jiang, Nicole E DeAngeli, David J Bucci, Travis P Todd
Although the retrosplenial cortex (RSC) is critically involved in spatial learning and memory, it appears to have more selective contributions to learning and memory for discrete cues. For example, damage to the RSC does not impair Pavlovian delay fear conditioning to a discrete auditory cue (e.g., tone), when RSC manipulation occurs just prior to, or shortly after, conditioning. In contrast, when lesions of the RSC occur following a substantial retention interval (e.g., 28 days), the RSC is necessary for retrieval of fear to the tone...
June 4, 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29863371/conjunctive-coding-in-an-evolved-spiking-model-of-retrosplenial-cortex
#20
Emily L Rounds, Andrew S Alexander, Douglas A Nitz, Jeffrey L Krichmar
Retrosplenial cortex (RSC) is an association cortex supporting spatial navigation and memory. However, critical issues remain concerning the forms by which its ensemble spiking patterns register spatial relationships that are difficult for experimental techniques to fully address. We therefore applied an evolutionary algorithmic optimization technique to create spiking neural network models that matched electrophysiologically observed spiking dynamics in rat RSC neuronal ensembles. Virtual experiments conducted on the evolved networks revealed a mixed selectivity coding capability that was not built into the optimization method, but instead emerged as a consequence of replicating biological firing patterns...
June 4, 2018: Behavioral Neuroscience
journal
journal
28544
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"