journal
MENU ▼
Read by QxMD icon Read
search

Mass Spectrometry Reviews

journal
https://www.readbyqxmd.com/read/30423209/the-role-of-mass-spectrometry-in-studies-of-glycation-processes-and-diabetes-management
#1
REVIEW
Sara D'Aronco, Sara Crotti, Marco Agostini, Pietro Traldi, Nino Cristiano Chilelli, Annunziata Lapolla
In the last decade, mass spectrometry has been widely employed in the study of diabetes. This was mainly due to the development of new, highly sensitive, and specific methods representing powerful tools to go deep into the biochemical and pathogenetic processes typical of the disease. The aim of this review is to give a panorama of the scientifically valid results obtained in this contest. The recent studies on glycation processes, in particular those devoted to the mechanism of production and to the reactivity of advanced glycation end products (AGEs, AGE peptides, glyoxal, methylglyoxal, dicarbonyl compounds) allowed to obtain a different view on short and long term complications of diabetes...
November 13, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/30372792/the-challenges-of-peptidomics-in-complementing-proteomics-in-a-clinical-context
#2
REVIEW
Evelyne Maes, Eline Oeyen, Kurt Boonen, Karin Schildermans, Inge Mertens, Patrick Pauwels, Dirk Valkenborg, Geert Baggerman
Naturally occurring peptides, including growth factors, hormones, and neurotransmitters, represent an important class of biomolecules and have crucial roles in human physiology. The study of these peptides in clinical samples is therefore as relevant as ever. Compared to more routine proteomics applications in clinical research, peptidomics research questions are more challenging and have special requirements with regard to sample handling, experimental design, and bioinformatics. In this review, we describe the issues that confront peptidomics in a clinical context...
October 29, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/30347118/preface-to-the-special-issue-of-mass-spectrometry-reviews
#3
EDITORIAL
Dietmar Kuck, Jürgen Grotemeyer
No abstract text is available yet for this article.
October 22, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/30300954/photoionization-and-photofragmentation-in-mass-spectrometry-with-visible-and-uv-lasers
#4
REVIEW
Frank Gunzer, Sascha Krüger, Jürgen Grotemeyer
Ever since the introduction of laser technology to the field of mass spectrometry, several disciplines evolved providing solutions to challenging scientific and analytical tasks in research and industry. Among these are techniques involving multiphoton ionization such as Resonance-Enhanced Multiphoton Ionization (REMPI, R2PI) and Mass-Analyzed Threshold Ionization (MATI) spectroscopy, a variant of Zero Kinetic Energy (ZEKE) spectroscopy, that possess the ability to selectively ionize certain preselected compounds out of complex mixtures, for example, environmental matrices, with a high level of efficiency...
October 9, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29603345/electron-ion-reaction-based-dissociation-a-powerful-ion-activation-method-for-the-elucidation-of-natural-product-structures
#5
REVIEW
Xiangfeng Chen, Ze Wang, Y-L Elaine Wong, Ri Wu, Feng Zhang, T-W Dominic Chan
The structural elucidation of natural products (NPs) remains a challenge due to their structurally diversities and unpredictable functionalities, motifs, and scaffolds. Tandem mass spectrometry (MS/MS) is an effective method that assists the full elucidation of complicated NP structures. Ion activation methods play a key role in determining the fragmentation pathways and the structural information obtained from MS/MS. Electron-ion reaction-based dissociation (ExD) methods, including electron capture dissociation (ECD), electron transfer dissociation (ETD), electron-induced dissociation (EID), and electron detachment dissociation (EDD), can induce the breakage of specific chemical bonds and the generation of distinct fragment ions...
November 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29603316/hydrogen-deuterium-exchange-in-mass-spectrometry
#6
REVIEW
Yury Kostyukevich, Thamina Acter, Alexander Zherebker, Arif Ahmed, Sunghwan Kim, Eugene Nikolaev
The isotopic exchange approach is in use since the first observation of such reactions in 1933 by Lewis. This approach allows the investigation of the pathways of chemical and biochemical reactions, determination of structure, composition, and conformation of molecules. Mass spectrometry has now become one of the most important analytical tools for the monitoring of the isotopic exchange reactions. Investigation of conformational dynamics of proteins, quantitative measurements, obtaining chemical, and structural information about individual compounds of the complex natural mixtures are mainly based on the use of isotope exchange in combination with high resolution mass spectrometry...
November 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29529716/cross-linked-peptide-identification-a-computational-forest-of-algorithms
#7
REVIEW
Şule Yılmaz, Genet A Shiferaw, Josep Rayo, Anastassios Economou, Lennart Martens, Elien Vandermarliere
Chemical cross-linking analyzed by mass spectrometry (XL-MS) has become an important tool in unravelling protein structure, dynamics, and complex formation. Because the analysis of cross-linked proteins with mass spectrometry results in specific computational challenges, many computational tools have been developed to identify cross-linked peptides from mass spectra and subsequently interpret the identified cross-links within their structural context. In this review, we will provide an overview of the different tools that are currently available to tackle the computational part of an XL-MS experiment...
November 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29425406/radical-solutions-principles-and-application-of-electron-based-dissociation-in-mass-spectrometry-based-analysis-of-protein-structure
#8
REVIEW
Frederik Lermyte, Dirk Valkenborg, Joseph A Loo, Frank Sobott
In recent years, electron capture (ECD) and electron transfer dissociation (ETD) have emerged as two of the most useful methods in mass spectrometry-based protein analysis, evidenced by a considerable and growing body of literature. In large part, the interest in these methods is due to their ability to induce backbone fragmentation with very little disruption of noncovalent interactions which allows inference of information regarding higher order structure from the observed fragmentation behavior. Here, we review the evolution of electron-based dissociation methods, and pay particular attention to their application in "native" mass spectrometry, their mechanism, determinants of fragmentation behavior, and recent developments in available instrumentation...
November 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29509966/negative-ion-laser-desorption-ionization-time-of-flight-mass-spectrometric-analysis-of-small-molecules-by-using-nanostructured-substrate-as-matrices
#9
REVIEW
Zian Lin, Zongwei Cai
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is an excellent analytical technique for rapid and sensitive analysis of macromolecules such as polymers and proteins. However, the main drawback of MALDI-TOF MS is its difficulty to detect small molecules with mass below 700 Da because of the intensive interference from MALDI matrix in the low mass region. In recent years there has been considerable interest in developing matrix-free laser desorption/ionization by using nanostructured substrates to substitute the conventional organic matrices, which is often referred as surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF MS)...
September 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29228471/mass-spectrometry-for-protein-sialoglycosylation
#10
REVIEW
Qiwei Zhang, Zack Li, Yawei Wang, Qi Zheng, Jianjun Li
Sialic acids are a family of structurally unique and negatively charged nine-carbon sugars, normally found at the terminal positions of glycan chains on glycoproteins and glycolipids. The glycosylation of proteins is a universal post-translational modification in eukaryotic species and regulates essential biological functions, in which the most common sialic acid is N-acetyl-neuraminic acid (2-keto-5-acetamido-3,5-dideoxy-D-glycero-D-galactononulopyranos-1-onic acid) (Neu5NAc). Because of the properties of sialic acids under general mass spectrometry (MS) conditions, such as instability, ionization discrimination, and mixed adducts, the use of MS in the analysis of protein sialoglycosylation is still challenging...
September 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29178389/mass-spectrometry-of-aerosol-particle-analogues-in-molecular-beam-experiments
#11
REVIEW
Michal Fárník, Jozef Lengyel
Nanometer-size particles such as ultrafine aerosol particles, ice nanoparticles, water nanodroplets, etc, play an important, however, not yet fully understood role in the atmospheric chemistry and physics. These species are often composed of water with admixture of other atmospherically relevant molecules. To mimic and investigate such particles in laboratory experiments, mixed water clusters with atmospherically relevant molecules can be generated in molecular beams and studied by various mass spectrometric methods...
September 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29120505/a-tutorial-in-small-molecule-identification-via-electrospray-ionization-mass-spectrometry-the-practical-art-of-structural-elucidation
#12
REVIEW
Thomas De Vijlder, Dirk Valkenborg, Filip Lemière, Edwin P Romijn, Kris Laukens, Filip Cuyckens
The identification of unknown molecules has been one of the cornerstone applications of mass spectrometry for decades. This tutorial reviews the basics of the interpretation of electrospray ionization-based MS and MS/MS spectra in order to identify small-molecule analytes (typically below 2000 Da). Most of what is discussed in this tutorial also applies to other atmospheric pressure ionization methods like atmospheric pressure chemical/photoionization. We focus primarily on the fundamental steps of MS-based structural elucidation of individual unknown compounds, rather than describing strategies for large-scale identification in complex samples...
September 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29120501/analysis-of-the-plasma-proteome-using-itraq-and-tmt-based-isobaric-labeling
#13
REVIEW
Robert Moulder, Santosh D Bhosale, David R Goodlett, Riitta Lahesmaa
Over the past decade, chemical labeling with isobaric tandem mass tags, such as isobaric tags for relative and absolute quantification reagents (iTRAQ) and tandem mass tag (TMT) reagents, has been employed in a wide range of different clinically orientated serum and plasma proteomics studies. In this review the scope of these works is presented with attention to the areas of research, methods employed and performance limitations. These applications have covered a wide range of diseases, disorders and infections, and have implemented a variety of different preparative and mass spectrometric approaches...
September 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/28802010/quality-control-in-mass-spectrometry-based-proteomics
#14
REVIEW
Wout Bittremieux, David L Tabb, Francis Impens, An Staes, Evy Timmerman, Lennart Martens, Kris Laukens
Mass spectrometry is a highly complex analytical technique and mass spectrometry-based proteomics experiments can be subject to a large variability, which forms an obstacle to obtaining accurate and reproducible results. Therefore, a comprehensive and systematic approach to quality control is an essential requirement to inspire confidence in the generated results. A typical mass spectrometry experiment consists of multiple different phases including the sample preparation, liquid chromatography, mass spectrometry, and bioinformatics stages...
September 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/30035815/mass-spectrometry-and-associated-technologies-delineate-the-advantageously-biomedical-capacity-of-siderophores-in-different-pathogenic-contexts
#15
REVIEW
Xialin Luo, Rui Guo, Xin Xu, Xian Li, Li Yao, Xijun Wang, Haitao Lu
Siderophores are chemically diverse small molecules produced by microorganisms for chelation of irons to maintain their survival and govern some important biological functions, especially those cause that infections in hosts. Still, siderophores can offer new insight into a better understanding of the diagnosis and treatments of infectious diseases from the siderophore biosynthesis and regulation perspective. Thus, this review aims to summarize the biomedical value and applicability of siderophores in pathogenic contexts by briefly reviewing mass spectrometry (MS)-based chemical biology and translational applications that involve diagnosis, pathogenesis, and therapeutic discovery for a variety of infectious conditions caused by different pathogens...
July 23, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/30024655/the-integration-of-lc-ms-and-nmr-for-the-analysis-of-low-molecular-weight-trace-analytes-in-complex-matrices
#16
REVIEW
Rose M Gathungu, Roger Kautz, Bruce S Kristal, Susan S Bird, Paul Vouros
This review discusses the integration of liquid chromatography (LC), mass spectrometry (MS), and nuclear magnetic resonance (NMR) in the comprehensive analysis of small molecules from complex matrices. We first discuss the steps taken toward making the three technologies compatible, so as to create an efficient analytical platform. The development of online LC-MS-NMR, highlighted by successful applications in the profiling of highly concentrated analytes (LODs 10 μg) is discussed next. This is followed by a detailed overview of the alternative approaches that have been developed to overcome the challenges associated with online LC-MS-NMR that primarily stem from the inherently low sensitivity of NMR...
July 19, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/30024641/the-vouros-odyssey-liquid-chromatography-mass-spectrometry-from-a-chromatographic-perspective-and-a-theseus-paradox
#17
REVIEW
Thomas Covey
This article tracts Paul Vouro's contributions to the field of liquid chromatography - mass spectrometry in the context of the history of the development of modern day LC/MS.
July 19, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29687922/analysis-of-carbohydrates-and-glycoconjugates-by-matrix-assisted-laser-desorption-ionization-mass-spectrometry-an-update-for-2013-2014
#18
REVIEW
David J Harvey
This review is the eighth update of the original article published in 1999 on the application of Matrix-assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2014. Topics covered in the first part of the review include general aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, fragmentation, and arrays. The second part of the review is devoted to applications to various structural types such as oligo- and poly- saccharides, glycoproteins, glycolipids, glycosides, and biopharmaceuticals...
July 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/28627748/on-line-reaction-monitoring-by-mass-spectrometry-modern-approaches-for-the-analysis-of-chemical-reactions
#19
REVIEW
Andrew Ray, Tony Bristow, Chris Whitmore, Jackie Mosely
The application of on-line mass spectrometry for direct analysis of chemical and other types of process continues to grow in importance and impact. The ability of the technique to characterize many aspects of a chemical reaction such as product and impurity formation, along with reactant consumption in a single experiment is key to its adoption and development. Innovations in ionization techniques and mass spectrometry instrumentation are enabling this adoption. An increasing range of ambient ionization techniques make on-line mass spectrometry applicable to a large range of chemistries...
July 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/28621817/gas-phase-basicities-of-polyfunctional-molecules-part-6-cyanides-and-isocyanides
#20
REVIEW
Guy Bouchoux
This paper gathers structural and thermochemical informations related to the gas-phase basicity of molecules containing cyanides (nitriles) and isocyanides (isonitriles) functional groups. It constitutes the sixth part of a general review devoted to gas-phase basicities of polyfunctional compounds. A large corpus of cyanides and isocyanides molecules is examined under seven major chapters. In the first one, a rapid overview of the definitions and methods leading to gas-phase basicity, GB, proton affinity, PA, and protonation entropy, Δp S°, is given...
July 2018: Mass Spectrometry Reviews
journal
journal
28491
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"