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Mass Spectrometry Reviews

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https://www.readbyqxmd.com/read/30035815/mass-spectrometry-and-associated-technologies-delineate-the-advantageously-biomedical-capacity-of-siderophores-in-different-pathogenic-contexts
#1
REVIEW
Xialin Luo, Rui Guo, Xin Xu, Xian Li, Li Yao, Xijun Wang, Haitao Lu
Siderophores are chemically diverse small molecules produced by microorganisms for chelation of irons to maintain their survival and govern some important biological functions, especially those cause that infections in hosts. Still, siderophores can offer new insight into a better understanding of the diagnosis and treatments of infectious diseases from the siderophore biosynthesis and regulation perspective. Thus, this review aims to summarize the biomedical value and applicability of siderophores in pathogenic contexts by briefly reviewing mass spectrometry (MS)-based chemical biology and translational applications that involve diagnosis, pathogenesis, and therapeutic discovery for a variety of infectious conditions caused by different pathogens...
July 23, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/30024655/the-integration-of-lc-ms-and-nmr-for-the-analysis-of-low-molecular-weight-trace-analytes-in-complex-matrices
#2
REVIEW
Rose M Gathungu, Roger Kautz, Bruce S Kristal, Susan S Bird, Paul Vouros
This review discusses the integration of liquid chromatography (LC), mass spectrometry (MS), and nuclear magnetic resonance (NMR) in the comprehensive analysis of small molecules from complex matrices. We first discuss the steps taken toward making the three technologies compatible, so as to create an efficient analytical platform. The development of online LC-MS-NMR, highlighted by successful applications in the profiling of highly concentrated analytes (LODs 10 μg) is discussed next. This is followed by a detailed overview of the alternative approaches that have been developed to overcome the challenges associated with online LC-MS-NMR that primarily stem from the inherently low sensitivity of NMR...
July 19, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/30024641/the-vouros-odyssey-liquid-chromatography-mass-spectrometry-from-a-chromatographic-perspective-and-a-theseus-paradox
#3
REVIEW
Thomas Covey
This article tracts Paul Vouro's contributions to the field of liquid chromatography - mass spectrometry in the context of the history of the development of modern day LC/MS.
July 19, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29957823/discovering-cellular-protein-protein-interactions-technological-strategies-and-opportunities
#4
REVIEW
Kevin Titeca, Irma Lemmens, Jan Tavernier, Sven Eyckerman
The analysis of protein interaction networks is one of the key challenges in the study of biology. It connects genotypes to phenotypes, and disruption often leads to diseases. Hence, many technologies have been developed to study protein-protein interactions (PPIs) in a cellular context. The expansion of the PPI technology toolbox however complicates the selection of optimal approaches for diverse biological questions. This review gives an overview of the binary and co-complex technologies, with the former evaluating the interaction of two co-expressed genetically tagged proteins, and the latter only needing the expression of a single tagged protein or no tagged proteins at all...
June 29, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29509966/negative-ion-laser-desorption-ionization-time-of-flight-mass-spectrometric-analysis-of-small-molecules-by-using-nanostructured-substrate-as-matrices
#5
REVIEW
Zian Lin, Zongwei Cai
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is an excellent analytical technique for rapid and sensitive analysis of macromolecules such as polymers and proteins. However, the main drawback of MALDI-TOF MS is its difficulty to detect small molecules with mass below 700 Da because of the intensive interference from MALDI matrix in the low mass region. In recent years there has been considerable interest in developing matrix-free laser desorption/ionization by using nanostructured substrates to substitute the conventional organic matrices, which is often referred as surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF MS)...
September 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29228471/mass-spectrometry-for-protein-sialoglycosylation
#6
REVIEW
Qiwei Zhang, Zack Li, Yawei Wang, Qi Zheng, Jianjun Li
Sialic acids are a family of structurally unique and negatively charged nine-carbon sugars, normally found at the terminal positions of glycan chains on glycoproteins and glycolipids. The glycosylation of proteins is a universal post-translational modification in eukaryotic species and regulates essential biological functions, in which the most common sialic acid is N-acetyl-neuraminic acid (2-keto-5-acetamido-3,5-dideoxy-D-glycero-D-galactononulopyranos-1-onic acid) (Neu5NAc). Because of the properties of sialic acids under general mass spectrometry (MS) conditions, such as instability, ionization discrimination, and mixed adducts, the use of MS in the analysis of protein sialoglycosylation is still challenging...
September 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29178389/mass-spectrometry-of-aerosol-particle-analogues-in-molecular-beam-experiments
#7
REVIEW
Michal Fárník, Jozef Lengyel
Nanometer-size particles such as ultrafine aerosol particles, ice nanoparticles, water nanodroplets, etc, play an important, however, not yet fully understood role in the atmospheric chemistry and physics. These species are often composed of water with admixture of other atmospherically relevant molecules. To mimic and investigate such particles in laboratory experiments, mixed water clusters with atmospherically relevant molecules can be generated in molecular beams and studied by various mass spectrometric methods...
September 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29120505/a-tutorial-in-small-molecule-identification-via-electrospray-ionization-mass-spectrometry-the-practical-art-of-structural-elucidation
#8
REVIEW
Thomas De Vijlder, Dirk Valkenborg, Filip Lemière, Edwin P Romijn, Kris Laukens, Filip Cuyckens
The identification of unknown molecules has been one of the cornerstone applications of mass spectrometry for decades. This tutorial reviews the basics of the interpretation of electrospray ionization-based MS and MS/MS spectra in order to identify small-molecule analytes (typically below 2000 Da). Most of what is discussed in this tutorial also applies to other atmospheric pressure ionization methods like atmospheric pressure chemical/photoionization. We focus primarily on the fundamental steps of MS-based structural elucidation of individual unknown compounds, rather than describing strategies for large-scale identification in complex samples...
September 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29120501/analysis-of-the-plasma-proteome-using-itraq-and-tmt-based-isobaric-labeling
#9
REVIEW
Robert Moulder, Santosh D Bhosale, David R Goodlett, Riitta Lahesmaa
Over the past decade, chemical labeling with isobaric tandem mass tags, such as isobaric tags for relative and absolute quantification reagents (iTRAQ) and tandem mass tag (TMT) reagents, has been employed in a wide range of different clinically orientated serum and plasma proteomics studies. In this review the scope of these works is presented with attention to the areas of research, methods employed and performance limitations. These applications have covered a wide range of diseases, disorders and infections, and have implemented a variety of different preparative and mass spectrometric approaches...
September 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/28802010/quality-control-in-mass-spectrometry-based-proteomics
#10
REVIEW
Wout Bittremieux, David L Tabb, Francis Impens, An Staes, Evy Timmerman, Lennart Martens, Kris Laukens
Mass spectrometry is a highly complex analytical technique and mass spectrometry-based proteomics experiments can be subject to a large variability, which forms an obstacle to obtaining accurate and reproducible results. Therefore, a comprehensive and systematic approach to quality control is an essential requirement to inspire confidence in the generated results. A typical mass spectrometry experiment consists of multiple different phases including the sample preparation, liquid chromatography, mass spectrometry, and bioinformatics stages...
September 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29687922/analysis-of-carbohydrates-and-glycoconjugates-by-matrix-assisted-laser-desorption-ionization-mass-spectrometry-an-update-for-2013-2014
#11
REVIEW
David J Harvey
This review is the eighth update of the original article published in 1999 on the application of Matrix-assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2014. Topics covered in the first part of the review include general aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, fragmentation, and arrays. The second part of the review is devoted to applications to various structural types such as oligo- and poly- saccharides, glycoproteins, glycolipids, glycosides, and biopharmaceuticals...
July 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/28627748/on-line-reaction-monitoring-by-mass-spectrometry-modern-approaches-for-the-analysis-of-chemical-reactions
#12
REVIEW
Andrew Ray, Tony Bristow, Chris Whitmore, Jackie Mosely
The application of on-line mass spectrometry for direct analysis of chemical and other types of process continues to grow in importance and impact. The ability of the technique to characterize many aspects of a chemical reaction such as product and impurity formation, along with reactant consumption in a single experiment is key to its adoption and development. Innovations in ionization techniques and mass spectrometry instrumentation are enabling this adoption. An increasing range of ambient ionization techniques make on-line mass spectrometry applicable to a large range of chemistries...
July 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/28621817/gas-phase-basicities-of-polyfunctional-molecules-part-6-cyanides-and-isocyanides
#13
REVIEW
Guy Bouchoux
This paper gathers structural and thermochemical informations related to the gas-phase basicity of molecules containing cyanides (nitriles) and isocyanides (isonitriles) functional groups. It constitutes the sixth part of a general review devoted to gas-phase basicities of polyfunctional compounds. A large corpus of cyanides and isocyanides molecules is examined under seven major chapters. In the first one, a rapid overview of the definitions and methods leading to gas-phase basicity, GB, proton affinity, PA, and protonation entropy, Δp S°, is given...
July 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/28436590/identification-of-small-molecules-using-accurate-mass-ms-ms-search
#14
REVIEW
Tobias Kind, Hiroshi Tsugawa, Tomas Cajka, Yan Ma, Zijuan Lai, Sajjan S Mehta, Gert Wohlgemuth, Dinesh Kumar Barupal, Megan R Showalter, Masanori Arita, Oliver Fiehn
Tandem mass spectral library search (MS/MS) is the fastest way to correctly annotate MS/MS spectra from screening small molecules in fields such as environmental analysis, drug screening, lipid analysis, and metabolomics. The confidence in MS/MS-based annotation of chemical structures is impacted by instrumental settings and requirements, data acquisition modes including data-dependent and data-independent methods, library scoring algorithms, as well as post-curation steps. We critically discuss parameters that influence search results, such as mass accuracy, precursor ion isolation width, intensity thresholds, centroiding algorithms, and acquisition speed...
July 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27611504/marine-environment-pollution-the-contribution-of-mass-spectrometry-to-the-study-of-seawater
#15
REVIEW
Emanuele Magi, Marina Di Carro
The study of marine pollution has been traditionally addressed to persistent chemicals, generally known as priority pollutants; a current trend in environmental analysis is a shift toward "emerging pollutants," defined as newly identified or previously unrecognized contaminants. The present review is focused on the peculiar contribution of mass spectrometry (MS) to the study of pollutants in the seawater compartment. The work is organized in five paragraphs where the most relevant groups of pollutants, both "classical" and "emerging," are presented and discussed, highlighting the relative data obtained by the means of different MS techniques...
July 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29905953/mass-spectrometry-is-a-multifaceted-weapon-to-be-used-in-the-battle-against-alzheimer-s-disease-amyloid-beta-peptides-and-beyond
#16
REVIEW
Giuseppe Grasso
Amyloid-β peptide (Aβ) accumulation and aggregation have been considered for many years the main cause of Alzheimer's disease (AD), and therefore have been the principal target of investigation as well as of the proposed therapeutic approaches (Grasso [2011] Mass Spectrom Rev. 30: 347-365). However, the amyloid cascade hypothesis, which considers Aβ accumulation the only causative agent of the disease, has proven to be incomplete if not wrong. In recent years, actors such as metal ions, oxidative stress, and other cofactors have been proposed as possible co-agents or, in some cases, main causative factors of AD...
June 15, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29889312/dna-adducts-formation-biological-effects-and-new-biospecimens-for-mass-spectrometric-measurements-in-humans
#17
REVIEW
Byeong Hwa Yun, Jingshu Guo, Medjda Bellamri, Robert J Turesky
Hazardous chemicals in the environment and diet or their electrophilic metabolites can form adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In addition, reactive intermediates can be generated in the body through oxidative stress and damage the genome. The identification and measurement of DNA adducts are required for understanding exposure and the causal role of a genotoxic chemical in cancer risk. Over the past three decades, 32 P-postlabeling, immunoassays, gas chromatography/mass spectrometry, and liquid chromatography/mass spectrometry (LC/MS) methods have been established to assess exposures to chemicals through measurements of DNA adducts...
June 11, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29889308/proteomics-biomarkers-for-solid-tumors-current-status-and-future-prospects
#18
REVIEW
Iwona Belczacka, Agnieszka Latosinska, Jochen Metzger, David Marx, Antonia Vlahou, Harald Mischak, Maria Frantzi
Cancer is a heterogeneous multifactorial disease, which continues to be one of the main causes of death worldwide. Despite the extensive efforts for establishing accurate diagnostic assays and efficient therapeutic schemes, disease prevalence is on the rise, in part, however, also due to improved early detection. For years, studies were focused on genomics and transcriptomics, aiming at the discovery of new tests with diagnostic or prognostic potential. However, cancer phenotypic characteristics seem most likely to be a direct reflection of changes in protein metabolism and function, which are also the targets of most drugs...
June 11, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29852530/the-expanding-role-of-mass-spectrometry-in-the-field-of-vaccine-development
#19
REVIEW
Vaneet Kumar Sharma, Ity Sharma, James Glick
Biological mass spectrometry has evolved as a core analytical technology in the last decade mainly because of its unparalleled ability to perform qualitative as well as quantitative profiling of enormously complex biological samples with high mass accuracy, sensitivity, selectivity and specificity. Mass spectrometry-based techniques are also routinely used to assess glycosylation and other post-translational modifications, disulfide bond linkage, and scrambling as well as for the detection of host cell protein contaminants in the field of biopharmaceuticals...
May 31, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/28509357/characterization-of-microbial-mixtures-by-mass-spectrometry
#20
REVIEW
Todd R Sandrin, Plamen A Demirev
MS applications in microbiology have increased significantly in the past 10 years, due in part to the proliferation of regulator-approved commercial MALDI MS platforms for rapid identification of clinical infections. In parallel, with the expansion of MS technologies in the "omics" fields, novel MS-based research efforts to characterize organismal as well as environmental microbiomes have emerged. Successful characterization of microorganisms found in complex mixtures of other organisms remains a major challenge for researchers and clinicians alike...
May 2018: Mass Spectrometry Reviews
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