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Mass Spectrometry Reviews

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https://www.readbyqxmd.com/read/28436590/identification-of-small-molecules-using-accurate-mass-ms-ms-search
#1
REVIEW
Tobias Kind, Hiroshi Tsugawa, Tomas Cajka, Yan Ma, Zijuan Lai, Sajjan S Mehta, Gert Wohlgemuth, Dinesh Kumar Barupal, Megan R Showalter, Masanori Arita, Oliver Fiehn
Tandem mass spectral library search (MS/MS) is the fastest way to correctly annotate MS/MS spectra from screening small molecules in fields such as environmental analysis, drug screening, lipid analysis, and metabolomics. The confidence in MS/MS-based annotation of chemical structures is impacted by instrumental settings and requirements, data acquisition modes including data-dependent and data-independent methods, library scoring algorithms, as well as post-curation steps. We critically discuss parameters that influence search results, such as mass accuracy, precursor ion isolation width, intensity thresholds, centroiding algorithms, and acquisition speed...
April 24, 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/28394457/john-hayes-1940-2017
#2
Paul Vouros, Dom Desiderio
No abstract text is available yet for this article.
May 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/26633258/a-mass-spectrometric-insight-into-the-origins-of-benign-gynecological-disorders
#3
REVIEW
Huiliang Yang, Wayne Bond Lau, Bonnie Lau, Yu Xuan, Shengtao Zhou, Linjie Zhao, Zhongyue Luo, Qiao Lin, Ning Ren, Xia Zhao, Yuquan Wei
Applications of mass spectrometry (MS) are rapidly expanding and encompass molecular and cellular biology. MS aids in the analysis of in vivo global molecular alterations, identifying potential biomarkers which may improve diagnosis and treatment of various pathologies. MS has added new dimensionality to medical research. Pioneering gynecologists now study molecular mechanisms underlying female reproductive pathology with MS-based tools. Although benign gynecologic disorders including endometriosis, adenomyosis, leiomyoma, and polycystic ovarian syndrome (PCOS) carry low mortality rates, they cause significant physical, mental, and social detriments...
May 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/26270629/analysis-of-carbohydrates-and-glycoconjugates-by-matrix-assisted-laser-desorption-ionization-mass-spectrometry-an-update-for-2011-2012
#4
REVIEW
David J Harvey
This review is the seventh update of the original article published in 1999 on the application of MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2012. General aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, and fragmentation are covered in the first part of the review and applications to various structural types constitute the remainder. The main groups of compound are oligo- and poly-saccharides, glycoproteins, glycolipids, glycosides, and biopharmaceuticals...
May 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/25988849/recent-developments-in-atmospheric-pressure-photoionization-mass-spectrometry
#5
REVIEW
Tiina J Kauppila, Jack A Syage, Thorsten Benter
Recent developments in atmospheric pressure photoionization (APPI), which is one of the three most important ionization techniques in liquid chromatography-mass spectrometry, are reviewed. The emphasis is on the practical aspects of APPI analysis, its combination with different separation techniques, novel instrumental developments - especially in gas chromatography and ambient mass spectrometry - and the applications that have appeared in 2009-2014. © 2015 Wiley Periodicals, Inc. Mass Spec Rev 36:423-449, 2017...
May 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/26280357/mass-spectrometry-in-the-pharmacokinetic-studies-of-anticancer-natural-products
#6
REVIEW
Sara Crotti, Bianca Posocco, Elena Marangon, Donato Nitti, Giuseppe Toffoli, Marco Agostini
In the history of medicine, nature has represented the main source of medical products. Indeed, the therapeutic use of plants certainly goes back to the Sumerian and Hippocrates and nowadays nature still represents the major source for new drugs discovery. Moreover, in the cancer treatment, drugs are either natural compounds or have been developed from naturally occurring parent compounds firstly isolated from plants and microbes from terrestrial and marine environment. A critical element of an anticancer drug is represented by its severe toxicities and, after administration, the drug concentrations have to remain in an appropriate range to be effective...
March 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/25975720/applications-of-dart-ms-for-food-quality-and-safety-assurance-in-food-supply-chain
#7
REVIEW
Tianyang Guo, Wei Yong, Yong Jin, Liya Zhang, Jiahui Liu, Sai Wang, Qilong Chen, Yiyang Dong, Haijia Su, Tianwei Tan
Direct analysis in real time (DART) represents a new generation of ion source which is used for rapid ionization of small molecules under ambient conditions. The combination of DART and various mass spectrometers allows analyzing multiple food samples with simple or no sample treatment, or in conjunction with prevailing protocolized sample preparation methods. Abundant applications by DART-MS have been reviewed in this paper. The DART-MS strategy applied to food supply chain (FSC), including production, processing, and storage and transportation, provides a comprehensive solution to various food components, contaminants, authenticity, and traceability...
March 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/25962722/mass-spectrometric-and-charge-density-studies-of-organometallic-clusters-photoionized-by-gigawatt-laser-pulses
#8
REVIEW
Purav Badani, Soumitra Das, Pramod Sharma, Rajesh Kumar Vatsa
Clusters on exposure to nanosecond laser pulses of gigawatt intensity exhibit a variety of photo-chemical processes such as fragmentation, intracluster reaction, ionization, Coulomb explosion, etc. Present article summarizes the experimental results obtained in our laboratory utilizing time-of-flight mass spectrometer which deal with one such aspect of cluster photochemistry related to generation of multiply charged atomic ions upon excessive ionization of cluster constituents (Coulomb explosion) at low intensity laser field (∼10(9)  W/cm(2) )...
March 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/25881008/mass-spectrometric-based-approaches-in-urine-metabolomics-and-biomarker-discovery
#9
REVIEW
Mona M Khamis, Darryl J Adamko, Anas El-Aneed
Urine metabolomics has recently emerged as a prominent field for the discovery of non-invasive biomarkers that can detect subtle metabolic discrepancies in response to a specific disease or therapeutic intervention. Urine, compared to other biofluids, is characterized by its ease of collection, richness in metabolites and its ability to reflect imbalances of all biochemical pathways within the body. Following urine collection for metabolomic analysis, samples must be immediately frozen to quench any biogenic and/or non-biogenic chemical reactions...
March 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/25869149/isotopocule-analysis-of-biologically-produced-nitrous-oxide-in-various-environments
#10
REVIEW
Sakae Toyoda, Naohiro Yoshida, Keisuke Koba
Natural abundance ratios of isotopocules, molecules that have the same chemical constitution and configuration, but that only differ in isotope substitution, retain a record of a compound's origin and reactions. A method to measure isotopocule ratios of nitrous oxide (N2 O) has been established by using mass analysis of molecular ions and fragment ions. The method has been applied widely to environmental samples from the atmosphere, ocean, fresh water, soils, and laboratory-simulation experiments. Results show that isotopocule ratios, particularly the (15) N-site preference (difference between isotopocule ratios (14) N(15) N(16) O/(14) N(14) N(16) O and (15) N(14) N(16) O/(14) N(14) N(16) O), have a wide range that depends on their production and consumption processes...
March 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27862149/obituary-klaus-biemann
#11
Dominic M Desiderio, Paul Vouros
No abstract text is available yet for this article.
January 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27862143/preface-to-the-special-issue-of-mass-spectrometry-reviews
#12
EDITORIAL
Dietmar Kuck, Jürgen Grotemeyer
No abstract text is available yet for this article.
January 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27859457/time-of-flight-mass-spectrometry-introduction-to-the-basics
#13
REVIEW
Ulrich Boesl
The intention of this tutorial is to introduce into the basic concepts of time-of-flight mass spectrometry, beginning with the most simple single-stage ion source with linear field-free drift region and continuing with two-stage ion sources combined with field-free drift regions and ion reflectors-the so-called reflectrons. Basic formulas are presented and discussed with the focus on understanding the physical relations of geometric and electric parameters, initial distribution of ionic parameters, ion flight times, and ion flight time incertitude...
January 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/26919394/a-timeline-of-stable-isotopes-and-mass-spectrometry-in-the-life-sciences
#14
REVIEW
Wolf D Lehmann
This review retraces the role of stable isotopes and mass spectrometry in the life sciences. The timeline is divided into four segments covering the years 1920-1950, 1950-1980, 1980-2000, and 2000 until today. For each period methodic progress and typical applications are discussed. Application of stable isotopes is driven by improvements of mass spectrometry, chromatography, and related fields in sensitivity, mass accuracy, structural specificity, complex sample handling ability, data output, and data evaluation...
January 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/26445267/electron-based-fragmentation-methods-in-mass-spectrometry-an-overview
#15
REVIEW
Yulin Qi, Dietrich A Volmer
Tandem mass spectrometry (MS/MS) provides detailed information for structural characterization of biomolecules. The combination of electron capture dissociation (ECD) techniques with Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) often provides unique ion-electron reactions and fragmentation channels in MS/MS. ECD is often a complimentary, sometimes even a superior tool to conventional MS/MS techniques. This article is aimed at providing a short overview of ECD-based fragmentation techniques (ExD) and optimization of ECD experiments for FTICR mass analyzers...
January 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/26398248/laser-ablation-icp-ms-application-in-biomedical-research
#16
REVIEW
Alessandra Sussulini, Julia Susanne Becker, Johanna Sabine Becker
In the last decade, the development of diverse bioanalytical methodologies based on mass spectrometry imaging has increased, as has their application in biomedical questions. The distribution analysis of elements (metals, semimetals, and non-metals) in biological samples is a point of interest in life sciences, especially within the context of metallomics, which is the scientific field that encompasses the global analysis of the entirety of elemental species inside a cell or tissue. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been efficiently employed to generate qualitative and quantitative maps of elemental distribution in thin tissue sections of a variety of biological samples, for example, brain, cartilage, spinal cord, etc...
January 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/26213263/human-sports-drug-testing-by-mass-spectrometry
#17
REVIEW
Wilhelm Schänzer, Mario Thevis
Since the installation of anti-doping rules and regulations and their international enforcement in the mid-1960s, mass spectrometry has been an integral part of doping control procedures. Although its utility was limited in the first decade, instrumental improvements and method optimizations have made mass spectrometry, in all its facets, an indispensable tool in modern sports drug testing. In this review, milestones in doping control analysis accomplished in Germany and reaching from the early developments to the current use of hyphenated mass spectrometric techniques concerning low- and high molecular mass analytes are presented...
January 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/28009933/mass-spectrometry-driven-drug-discovery-for-development-of-herbal-medicine
#18
REVIEW
Aihua Zhang, Hui Sun, Xijun Wang
Herbal medicine (HM) has made a major contribution to the drug discovery process with regard to identifying products compounds. Currently, more attention has been focused on drug discovery from natural compounds of HM. Despite the rapid advancement of modern analytical techniques, drug discovery is still a difficult and lengthy process. Fortunately, mass spectrometry (MS) can provide us with useful structural information for drug discovery, has been recognized as a sensitive, rapid, and high-throughput technology for advancing drug discovery from HM in the post-genomic era...
December 23, 2016: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27862147/signal-preprocessing-multivariate-analysis-and-software-tools-for-ma-ldi-tof-mass-spectrometry-imaging-for-biological-applications
#19
REVIEW
Pere Ràfols, Dídac Vilalta, Jesús Brezmes, Nicolau Cañellas, Esteban Del Castillo, Oscar Yanes, Noelia Ramírez, Xavier Correig
Mass spectrometry imaging (MSI) is a label-free analytical technique capable of molecularly characterizing biological samples, including tissues and cell lines. The constant development of analytical instrumentation and strategies over the previous decade makes MSI a key tool in clinical research. Nevertheless, most MSI studies are limited to targeted analysis or the mere visualization of a few molecular species (proteins, peptides, metabolites, or lipids) in a region of interest without fully exploiting the possibilities inherent in the MSI technique, such as tissue classification and segmentation or the identification of relevant biomarkers from an untargeted approach...
November 9, 2016: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27750373/mass-spectrometric-strategies-for-the-investigation-of-biomarkers-of-illicit-drug-use-in-wastewater
#20
Félix Hernández, Sara Castiglioni, Adrian Covaci, Pim de Voogt, Erik Emke, Barbara Kasprzyk-Hordern, Christoph Ort, Malcolm Reid, Juan V Sancho, Kevin V Thomas, Alexander L N van Nuijs, Ettore Zuccato, Lubertus Bijlsma
The analysis of illicit drugs in urban wastewater is the basis of wastewater-based epidemiology (WBE), and has received much scientific attention because the concentrations measured can be used as a new non-intrusive tool to provide evidence-based and real-time estimates of community-wide drug consumption. Moreover, WBE allows monitoring patterns and spatial and temporal trends of drug use. Although information and expertise from other disciplines is required to refine and effectively apply WBE, analytical chemistry is the fundamental driver in this field...
October 17, 2016: Mass Spectrometry Reviews
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