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Mass Spectrometry Reviews

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https://www.readbyqxmd.com/read/29687922/analysis-of-carbohydrates-and-glycoconjugates-by-matrix-assisted-laser-desorption-ionization-mass-spectrometry-an-update-for-2013-2014
#1
REVIEW
David J Harvey
This review is the eighth update of the original article published in 1999 on the application of Matrix-assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2014. Topics covered in the first part of the review include general aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, fragmentation, and arrays. The second part of the review is devoted to applications to various structural types such as oligo- and poly- saccharides, glycoproteins, glycolipids, glycosides, and biopharmaceuticals...
April 17, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29660147/free-radical-initiated-peptide-sequencing-frips-based-cross-linkers-for-improved-peptide-and-protein-structure-analysis
#2
REVIEW
Claudio Iacobucci, Mathias Schäfer, Andrea Sinz
Free radical-initiated peptide sequencing (FRIPS) has recently been introduced as an analytical strategy to create peptide radical ions in a predictable and effective way by collisional activation of specifically modified peptides ions. FRIPS is based on the unimolecular dissociation of open-shell ions and yields fragments that resemble those obtained by electron capture dissociation (ECD) or electron transfer dissociation (ETD). In this review article, we describe the fundamentals of FRIPS and highlight its fruitful combination with chemical cross-linking/mass spectrometry (MS) as a highly promising option to derive complementary structural information of peptides and proteins...
April 16, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29603345/electron-ion-reaction-based-dissociation-a-powerful-ion-activation-method-for-the-elucidation-of-natural-product-structures
#3
REVIEW
Xiangfeng Chen, Ze Wang, Y-L Elaine Wong, Ri Wu, Feng Zhang, T-W Dominic Chan
The structural elucidation of natural products (NPs) remains a challenge due to their structurally diversities and unpredictable functionalities, motifs, and scaffolds. Tandem mass spectrometry (MS/MS) is an effective method that assists the full elucidation of complicated NP structures. Ion activation methods play a key role in determining the fragmentation pathways and the structural information obtained from MS/MS. Electron-ion reaction-based dissociation (ExD) methods, including electron capture dissociation (ECD), electron transfer dissociation (ETD), electron-induced dissociation (EID), and electron detachment dissociation (EDD), can induce the breakage of specific chemical bonds and the generation of distinct fragment ions...
March 30, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29603316/hydrogen-deuterium-exchange-in-mass-spectrometry
#4
REVIEW
Yury Kostyukevich, Thamina Acter, Alexander Zherebker, Arif Ahmed, Sunghwan Kim, Eugene Nikolaev
The isotopic exchange approach is in use since the first observation of such reactions in 1933 by Lewis. This approach allows the investigation of the pathways of chemical and biochemical reactions, determination of structure, composition, and conformation of molecules. Mass spectrometry has now become one of the most important analytical tools for the monitoring of the isotopic exchange reactions. Investigation of conformational dynamics of proteins, quantitative measurements, obtaining chemical, and structural information about individual compounds of the complex natural mixtures are mainly based on the use of isotope exchange in combination with high resolution mass spectrometry...
March 30, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29603315/molecules-and-elements-for-quantitative-bioanalysis-the-allure-of-using-electrospray-maldi-and-icp-mass-spectrometry-side-by-side
#5
REVIEW
Michael W Linscheid
To understand biological processes, not only reliable identification, but quantification of constituents in biological processes play a pivotal role. This is especially true for the proteome: protein quantification must follow protein identification, since sometimes minute changes in abundance tell the real tale. To obtain quantitative data, many sophisticated strategies using electrospray and MALDI mass spectrometry (MS) have been developed in recent years. All of them have advantages and limitations. Several years ago, we started to work on strategies, which are principally capable to overcome some of these limits...
March 30, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29529716/cross-linked-peptide-identification-a-computational-forest-of-algorithms
#6
REVIEW
Şule Yılmaz, Genet A Shiferaw, Josep Rayo, Anastassios Economou, Lennart Martens, Elien Vandermarliere
Chemical cross-linking analyzed by mass spectrometry (XL-MS) has become an important tool in unravelling protein structure, dynamics, and complex formation. Because the analysis of cross-linked proteins with mass spectrometry results in specific computational challenges, many computational tools have been developed to identify cross-linked peptides from mass spectra and subsequently interpret the identified cross-links within their structural context. In this review, we will provide an overview of the different tools that are currently available to tackle the computational part of an XL-MS experiment...
March 12, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29509966/negative-ion-laser-desorption-ionization-time-of-flight-mass-spectrometric-analysis-of-small-molecules-by-using-nanostructured-substrate-as-matrices
#7
REVIEW
Zian Lin, Zongwei Cai
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is an excellent analytical technique for rapid and sensitive analysis of macromolecules such as polymers and proteins. However, the main drawback of MALDI-TOF MS is its difficulty to detect small molecules with mass below 700 Da because of the intensive interference from MALDI matrix in the low mass region. In recent years there has been considerable interest in developing matrix-free laser desorption/ionization by using nanostructured substrates to substitute the conventional organic matrices, which is often referred as surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF MS)...
March 6, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29486047/challenges-and-emergent-solutions-for-lc-ms-ms-based-untargeted-metabolomics-in-diseases
#8
REVIEW
Liang Cui, Haitao Lu, Yie Hou Lee
In the past decade, advances in liquid chromatography-mass spectrometry (LC-MS) have revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply, researchers are now primed to uncover key metabolites and their associations with diseases. The employment of untargeted metabolomics has led to new biomarker discoveries and a better mechanistic understanding of diseases with applications in precision medicine. However, many major pertinent challenges remain. First, compound identification has been poor, and left an overwhelming number of unidentified peaks...
February 27, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29415345/james-augustus-mccloskey-1936-2017
#9
Paul Vouros, Dominic Desiderio
No abstract text is available yet for this article.
March 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27579891/mass-spectrometry-derived-systems-biology-technologies-delineate-the-system-s-biochemical-applications-of-siderophores
#10
REVIEW
Qiao Su, Guang Xu, Tianbing Guan, Yumei Que, Haitao Lu
Siderophores are chemically diverse secondary metabolites that primarily assist the host organisms to chelate iron. Siderophores are biosynthesized by many biological organisms, including bacteria, fungi, and plants and they are responsible for a variety of biological functions beyond capture iron. Thus, they could provide a novel understanding of host-pathogen interactions, plant physiology, disease pathogenesis, and drug development. However, knowledge gaps in analytical technologies, chemistry, and biology have severely impeded the applications of siderophores, and a new strategy is urgently needed to bridge these gaps...
March 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27420733/the-quest-for-improved-reproducibility-in-maldi-mass-spectrometry
#11
REVIEW
Matthew B O'Rourke, Steven P Djordjevic, Matthew P Padula
Reproducibility has been one of the biggest hurdles faced when attempting to develop quantitative protocols for MALDI mass spectrometry. The heterogeneous nature of sample recrystallization has made automated sample acquisition somewhat "hit and miss" with manual intervention needed to ensure that all sample spots have been analyzed. In this review, we explore the last 30 years of literature and anecdotal evidence that has attempted to address and improve reproducibility in MALDI MS. Though many methods have been attempted, we have discovered a significant publication history surrounding the use of nitrocellulose as a substrate to improve homogeneity of crystal formation and therefore reproducibility...
March 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27403762/mass-spectrometric-epitope-mapping
#12
REVIEW
Kwabena F M Opuni, Mahmoud Al-Majdoub, Yelena Yefremova, Reham F El-Kased, Cornelia Koy, Michael O Glocker
Mass spectrometric epitope mapping has become a versatile method to precisely determine a soluble antigen's partial structure that directly interacts with an antibody in solution. Typical lengths of investigated antigens have increased up to several 100 amino acids while experimentally determined epitope peptides have decreased in length to on average 10-15 amino acids. Since the early 1990s more and more sophisticated methods have been developed and have forwarded a bouquet of suitable approaches for epitope mapping with immobilized, temporarily immobilized, and free-floating antibodies...
March 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27341181/recent-2000-2015-developments-in-the-analysis-of-minor-unknown-natural-products-based-on-characteristic-fragment-information-using-lc-ms
#13
REVIEW
Tian Cai, Ze-Qin Guo, Xiao-Ying Xu, Zhi-Jun Wu
Liquid chromatography-Mass Spectrometry (LC-MS) has been widely used in natural product analysis. Global detection and identification of nontargeted components are desirable in natural product research, for example, in quality control of Chinese herbal medicine. Nontargeted components analysis continues to expand to exciting life science application domains such as metabonomics. With this background, the present review summarizes recent developments in the analysis of minor unknown natural products using LC-MS and mainly focuses on the determination of the molecular formulae, selection of precursor ions, and characteristic fragmentation patterns of the known compounds...
March 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27276657/phospholipids-as-cancer-biomarkers-mass-spectrometry-based-analysis
#14
REVIEW
Raju Bandu, Hyuck Jun Mok, Kwang Pyo Kim
Lipids, particularly phospholipids (PLs), are key components of cellular membrane. PLs play important and diverse roles in cells such as chemical-energy storage, cellular signaling, cell membranes, and cell-cell interactions in tissues. All these cellular processes are pertinent to cells that undergo transformation, cancer progression, and metastasis. Thus, there is a strong possibility that some classes of PLs are expected to present in cancer cells and tissues in cellular physiology. The mass spectrometric soft-ionization techniques, electrospray ionization (ESI), and matrix-assisted laser desorption/ionization (MALDI) are well-established in the proteomics field, have been used for lipidomic analysis in cancer research...
March 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27275644/gas-phase-basicities-of-polyfunctional-molecules-part-5-non-aromatic-sp-2-nitrogen-containing-compounds
#15
REVIEW
Guy Bouchoux, Mirjana Eckert-Maksic
This paper constitutes the fifth part of a general review of the gas-phase protonation thermochemistry of polyfunctional molecules (Part 1: Theory and methods, Mass Spectrom Rev 2007, 26:775-835, Part 2: Saturated basic sites, Mass Spectrom Rev 2012, 31:353-390, Part 3: Amino acids, Mass Spectrom Rev 2012, 31:391-435, Part 4: Carbonyl as basic site, Mass Spectrom Rev 2015, 34:493-534). This part is devoted to non-aromatic molecules characterized by a lone pair located on a sp2 nitrogen atom, it embraces functional groups such as imines, amidines, guanidines, diazenes, hydrazines, oximes, and phosphazenes...
March 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27271453/direct-analysis-in-real-time-mass-spectrometry-dart-ms-in-forensic-and-security-applications
#16
REVIEW
Matthew J Pavlovich, Brian Musselman, Adam B Hall
Over the last decade, direct analysis in real time (DART) has emerged as a viable method for fast, easy, and reliable "ambient ionization" for forensic analysis. The ability of DART to generate ions from chemicals that might be present at the scene of a criminal activity, whether they are in the gas, liquid, or solid phase, with limited sample preparation has made the technology a useful analytical tool in numerous forensic applications. This review paper summarizes many of those applications, ranging from the analysis of trace evidence to security applications, with a focus on providing the forensic scientist with a resource for developing their own applications...
March 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29425406/radical-solutions-principles-and-application-of-electron-based-dissociation-in-mass-spectrometry-based-analysis-of-protein-structure
#17
REVIEW
Frederik Lermyte, Dirk Valkenborg, Joseph A Loo, Frank Sobott
In recent years, electron capture (ECD) and electron transfer dissociation (ETD) have emerged as two of the most useful methods in mass spectrometry-based protein analysis, evidenced by a considerable and growing body of literature. In large part, the interest in these methods is due to their ability to induce backbone fragmentation with very little disruption of noncovalent interactions which allows inference of information regarding higher order structure from the observed fragmentation behavior. Here, we review the evolution of electron-based dissociation methods, and pay particular attention to their application in "native" mass spectrometry, their mechanism, determinants of fragmentation behavior, and recent developments in available instrumentation...
February 9, 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27186965/spatial-perspectives-in-the-redox-code-mass-spectrometric-proteomics-studies-of-moonlighting-proteins
#18
REVIEW
Gabriella Pinto, Marko Radulovic, Jasminka Godovac-Zimmermann
The Redox Code involves specific, reversible oxidative changes in proteins that modulate protein tertiary structure, interactions, trafficking, and activity, and hence couple the proteome to the metabolic/oxidative state of cells. It is currently a major focus of study in cell biology. Recent studies of dynamic cellular spatial reorganization with MS-based subcellular-spatial-razor proteomics reveal that protein constituents of many subcellular structures, including mitochondria, the endoplasmic reticulum, the plasma membrane, and the extracellular matrix, undergo changes in their subcellular abundance/distribution in response to oxidative stress...
January 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27182900/historical-and-contemporary-stable-isotope-tracer-approaches-to-studying-mammalian-protein-metabolism
#19
REVIEW
Daniel James Wilkinson
Over a century ago, Frederick Soddy provided the first evidence for the existence of isotopes; elements that occupy the same position in the periodic table are essentially chemically identical but differ in mass due to a different number of neutrons within the atomic nucleus. Allied to the discovery of isotopes was the development of some of the first forms of mass spectrometers, driven forward by the Nobel laureates JJ Thomson and FW Aston, enabling the accurate separation, identification, and quantification of the relative abundance of these isotopes...
January 2018: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27155889/a-review-on-the-mass-spectrometric-studies-of-americium-present-status-and-future-perspective
#20
REVIEW
Suresh Kumar Aggarwal
The manuscript reviews the various mass spectrometric techniques for analysis and chemical studies of Americium. These methods include thermal ionization mass spectrometry (TIMS), and inductively coupled plasma source mass spectrometry (ICPMS) for the determination of Am isotope ratios and concentration in nuclear fuel samples of interest in nuclear technology, and in complex biological and environmental samples. Ultra-sensitive mass spectrometric techniques of resonance-ionization mass spectrometry (RIMS), and accelerator-based mass spectrometry (AMS) are also discussed...
January 2018: Mass Spectrometry Reviews
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