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Krisztina Horváth, Zsuzsanna Aschermann, Márton Kovács, Attila Makkos, Márk Harmat, József Janszky, Sámuel Komoly, Kázmér Karádi, Norbert Kovács
BACKGROUND: Minimal clinically important difference (MCID) is the smallest change in an outcome, which a patient identifies as meaningful. Although the 2 most frequently applied Parkinson's disease (PD) "quality of life" questionnaires (the PDQ-39 and PDQ-8) provide encouragingly similar results, their MCID thresholds appear to be vastly different. Our aim was to calculate the MCID estimates for both PDQ-39 and PDQ-8 Summary Indices (PDQ-39-SI and PDQ-8-SI) by the utilization of both anchor- and distribution-based techniques...
February 4, 2017: Neuroepidemiology
Yu-Hsuan Chuang, Christina M Lill, Pei-Chen Lee, Johnni Hansen, Christina F Lassen, Lars Bertram, Naomi Greene, Janet S Sinsheimer, Beate Ritz
BACKGROUND AND PURPOSE: Drinking caffeinated coffee has been reported to provide protection against Parkinson's disease (PD). Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD risk. METHODS: In a population-based case-control study (PASIDA) in Denmark (1,556 PD patients and 1,606 birth year- and gender-matched controls), we assessed interactions between lifetime coffee consumption and 3 polymorphisms in ADORA2A and CYP1A2 for all subjects, and incident and prevalent PD cases separately using logistic regression models...
2016: Neuroepidemiology
Rashmee U Shah, Austin B Rupp, Danielle Mowery, Mingyuan Zhang, Greg Stoddard, Vikrant Deshmukh, Bruce E Bray, Rachel Hess, Matthew T Rondina
BACKGROUND: Direct oral anticoagulants (DOACs) have the potential to improve stroke prevention among atrial fibrillation (AF) patients. We sought to determine if oral anticoagulation (OAC) treatment rates have increased since the approval of DOACs. METHODS: We identified 6,688 patients with AF at an academic medical center from January 2008 to June 2015. We examined OAC prescription rates over time and according to CHA2DS2VASc score using multivariable Poisson regression models, with an interaction term between risk score and year of AF diagnosis...
2016: Neuroepidemiology
Caroline Arquizan, Luc Bauchet
No abstract text is available yet for this article.
2016: Neuroepidemiology
Md Mohaimenul Islam, Usman Iqbal, Bruno Walther, Suleman Atique, Navneet Kumar Dubey, Phung-Anh Nguyen, Tahmina Nasrin Poly, Jakir Hossain Bhuiyan Masud, Yu-Chuan Jack Li, Syed-Abdul Shabbir
BACKGROUND: Benzodiazepines are a widely used medication in developed countries, particularly among elderly patients. However, benzodiazepines are known to affect memory and cognition and might thus enhance the risk of dementia. The objective of this review is to synthesize evidence from observational studies that evaluated the association between benzodiazepines use and dementia risk. SUMMARY: We performed a systematic review and meta-analysis of controlled observational studies to evaluate the risk of benzodiazepines use on dementia outcome...
2016: Neuroepidemiology
Manav V Vyas, Daniel G Hackam, Frank L Silver, Audrey Laporte, Moira K Kapral
BACKGROUND: Stroke leads to a substantial societal economic burden. Loss of productivity among stroke survivors is a significant contributor to the indirect costs associated with stroke. We aimed to characterize productivity and factors associated with employability in stroke survivors. METHODS: We used the Canadian Community Health Survey 2011-2012 to identify stroke survivors and employment status. We used multivariable logistic models to determine the impact of stroke on employment and on factors associated with employability, and used Heckman models to estimate the effect of stroke on productivity (number of hours worked/week and hourly wages)...
2016: Neuroepidemiology
Hong-Bae Kim, Seung-Kwon Myung, Sun-Mi Lee, Yon Chul Park
BACKGROUND: Previous observational epidemiological studies have reported inconsistent findings about the association between longer durations of sleep and the risk of cognitive impairment and dementia. To investigate the association between longer durations of sleep and the risk of cognitive decline, we performed a meta-analysis of observational studies. METHODS: We searched PubMed, EMBASE, and the bibliographies of relevant articles to retrieve additional studies in July 2015...
2016: Neuroepidemiology
Benjamin Allès, Camille Pouchieu, Anne Gruber, Pierre Lebailly, Hugues Loiseau, Pascale Fabbro-Peray, Luc Letenneur, Isabelle Baldi
BACKGROUND: Little is known about the relationship between diet and central nervous system (CNS) tumors, especially in terms of their histological subtypes. This study investigated the overall associations between food groups, alcohol intake and CNS tumors, and in particular about the associations between neuroepithelial tumors and meningiomas. METHODS: Data were collected through the CERENAT (CEREbral tumors: a NATional study) case-control study conducted in France during the period 2004-2010...
2016: Neuroepidemiology
Germán Sánchez-Díaz, Greta Arias-Merino, Ana Villaverde-Hueso, Antonio Morales-Piga, Ignacio Abaitua-Borda, Manuel Hens, Eva Bermejo-Sánchez, Manuel Posada de la Paz, Verónica Alonso-Ferreira
BACKGROUND: Huntington's disease (HD) is a progressive neurodegenerative condition characterized by chorea, dystonia, behavioral disturbances and cognitive decline. The aim of this study is to assess temporal and spatial changes on mortality attributable to HD over 30 years in Spain. METHODS: HD data were extracted from the nationwide mortality registry for the period 1984-2013. Annual and 5-year gender- and age-specific rates adjusted for the standard European population were calculated...
2016: Neuroepidemiology
(no author information available yet)
No abstract text is available yet for this article.
2016: Neuroepidemiology
Keiko Murakami, Hirohito Metoki, Michihiro Satoh, Kei Asayama, Miki Hosaka, Ayako Matsuda, Ryusuke Inoue, Megumi Tsubota-Utsugi, Takahisa Murakami, Kyoko Nomura, Masahiro Kikuya, Yutaka Imai, Takayoshi Ohkubo
BACKGROUND: The association between stroke and menstrual factors, for example, age at the time of menarche and age at the time of menopause, has not been well studied so far and the findings are inconsistent. We sought to examine this association in Japanese postmenopausal women. METHODS: We followed 1,412 postmenopausal women aged ≥35 without a history of stroke in Ohasama, Japan. Baseline data were collected using a self-administered questionnaire. Adjusted hazard ratios (HRs) and 95% CIs of each menstrual factor for stroke incidence were calculated using the Cox proportional hazard model...
2016: Neuroepidemiology
Jinyoung Youn, Eungseok Oh, Jinse Park, Suyeon Park, Ji Sun Kim, Wooyoung Jang
BACKGROUND: Considering the increasing prevalence of Parkinson's disease (PD), the lack of awareness and knowledge regarding PD may be barriers to the early diagnosis and the provision of optimal care to affected patients. This study aimed to investigate the awareness and knowledge about PD among the general population in South Korea and to identify the factors that are associated with these parameters. METHODS: We developed a structured, 22-item questionnaire that consisted of both open-ended and close-ended questions...
2016: Neuroepidemiology
Zhen Liu, Ting-Ting Zhang, Jie Yu, Ying-Li Liu, Su-Fen Qi, Jing-Jing Zhao, Dian-Wu Liu, Qing-Bao Tian
BACKGROUND AND AIM: Several epidemiological studies have reported the association between obesity and multiple sclerosis (MS). METHODS: A literature search of the observational studies, published as original articles in English before December 2015, was performed using electronic databases. RESULTS: Five observational studies were included, of which 3 were case-control studies and 2 were cohort studies. The pooled relative risk (RR) for overweight and obesity during childhood and adolescence compared with normal weight (body mass index = 18...
2016: Neuroepidemiology
Darwin R Labarthe, George Howard, Monika M Safford, Virginia J Howard, Suzanne E Judd, Mary Cushman, Brett M Kissela
BACKGROUND: Is the high stroke mortality in the Southeastern parts of the United States driven by differences in stroke incidence or case-fatality? This question remains unanswered. Differences in incidence would underscore the need for stroke prevention, while differences in case fatality would call for improved stroke care. METHODS: Quartiles of US counties were defined by stroke mortality, and this gradient was related with stroke incidence and stroke case fatality in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study, where 1,317 incident stroke events (of which 242 were fatal) occurred among 29,650 participants...
2016: Neuroepidemiology
Marco Cicciù
No abstract text is available yet for this article.
2016: Neuroepidemiology
Nian-Sheng Tzeng, Chi-Hsiang Chung, Chin-Bin Yeh, Ren-Yeong Huang, Da-Yo Yuh, San-Yuan Huang, Ru-Band Lu, Hsin-An Chang, Yu-Chen Kao, Wei-Shan Chiang, Yu-Ching Chou, Wu-Chien Chien
BACKGROUND: Chronic periodontitis and gingivitis are associated with various diseases; however, their impact on dementia is yet to be elucidated. This study is aimed at investigating the association between chronic periodontitis and gingivitis, and the risk of developing dementia. METHODS: A total of 2,207 patients, with newly diagnosed chronic periodontitis and gingivitis between January 1, 2000 and December 31, 2000, were selected from the National Health Insurance Research Database of Taiwan, along with 6,621 controls matched for sex and age...
2016: Neuroepidemiology
Clara Weil, Neta Zach, Shay Rishoni, Varda Shalev, Gabriel Chodick
BACKGROUND: Globally, the annual incidence and prevalence of amyotrophic lateral sclerosis (ALS) are estimated at 1.9 and 4.5 per 100,000 population, respectively. This study is aimed at describing the epidemiology of ALS in Israel in a real-world setting. METHODS: A retrospective study was performed using the databases of Maccabi Healthcare Services (MHS), a 2-million-member health maintenance organization in Israel. The study included all MHS adults diagnosed with ALS between 1997 and 2013...
2016: Neuroepidemiology
Astrid M Suchy-Dicey, Dean Shibata, Lyle G Best, Steven P Verney, William T Longstreth, Elisa T Lee, Peter M Okin, Richard Devereux, Marcia O'Leary, Tauqeer Ali, Paul N Jensen, Clemma Muller, Lonnie A Nelson, Everett Rhoades, Tara Madhyastha, Thomas J Grabowski, Norman Beauchamp, Jason G Umans, Dedra Buchwald
The Cerebrovascular Disease and its Consequences in American Indians (CDCAI) Study recruited surviving members of a 20-year, longitudinal, population-based cohort of American Indians focused on cardiovascular disease, its risk factors, and its consequences. The goal of the CDCAI Study is to characterize the burden, risk factors, and manifestations of vascular brain injury identified on cranial MRI. The CDCAI Study investigators enrolled 1,033 participants aged 60 and older from 11 American Indian communities and tribes in the Northern Plains, Southern Plains, and Southwestern United States...
2016: Neuroepidemiology
Fabrizio D'Ovidio, Angelo d'Errico, Elena Farina, Andrea Calvo, Giuseppe Costa, Adriano Chiò
BACKGROUND: An increased frequency of psychotic disorders in amyotrophic lateral sclerosis (ALS) families compared to controls has been reported. Aim of our study was to assess the relationship between nervous system drugs prescriptions and subsequent onset of ALS in a large Italian population. METHODS: The study population consisted of all subjects over 15 years at the 2001 Italian census, resident in Turin since 1996 (n = 687,324), followed up for ALS occurrence from 2002 to 2014...
2016: Neuroepidemiology
Wesley T O'Neal, Hooman Kamel, Dawn Kleindorfer, Suzanne E Judd, George Howard, Virginia J Howard, Elsayed Z Soliman
BACKGROUND: It is currently unknown if premature atrial contractions (PACs) detected on the routine screening electrocardiogram are associated with an increased risk of ischemic stroke. METHODS: We examined the association between PACs and ischemic stroke in 22,975 (mean age 64 ± 9.2; 56% women; 40% black) participants from the Reasons for Geographic and Racial Differences in Stroke study. Participants who were free of stroke at baseline were included. PACs were detected from centrally read electrocardiograms at baseline...
2016: Neuroepidemiology
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