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Journal of Clinical Apheresis

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https://www.readbyqxmd.com/read/28841764/how-do-people-become-plasma-and-platelet-donors-in-a-vnr-context
#1
Johanne Charbonneau, Marie-Soleil Cloutier, Balia Fainstein
BACKGROUND: The demand for therapeutic plasma-derived products poses a challenge to blood collection agencies (BCAs). In 2014-2015, the volume of plasma sent for fractionation met 17.7% of Quebec's needs for immunoglobulins. This article aims to offer an exploration of the paths blood donors follow in order to become plasma and platelet donors (PPDs). STUDY DESIGN AND METHOD: This analysis is based on semi-structured interviews with 50 PPDs in Quebec, Canada. Our analysis focused on the occurrence of events and the presence of contextual elements identified through: (1) factual data on PPDs; and (2) what PPDs identified as being an influence on their donation experience...
August 25, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28833438/mononuclear-cell-collection-for-extracorporeal-photopheresis-concentrate-characteristics-for-off-line-uv-a-irradiation-procedure
#2
Nicola Piccirillo, Rossana Putzulu, Giuseppina Massini, Assunta Gessica Fiore, Patrizia Chiusolo, Simona Sica, Gina Zini
BACKGROUND AND OBJECTIVE: Extracorporeal photopheresis (ECP) is the most represented cell therapy for treatment of cutaneous T-cell lymphoma, graft-versus host disease and organ rejection. We analyzed our experience in ECP using 2 cell separators (Cobe Spectra and Spectra Optia) focusing on leukapheretic product characteristics, UV-A irradiation procedure and entire ECP process. MATERIALS AND METHODS: We collected data of patients undergoing ECP between January 2012 and February 2015 in order to evaluate collection procedures performed using Cobe Spectra and Spectra Optia, mononuclear cell product, UV-A photoirradiation procedure by Pit System...
August 22, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28833474/short-term-side-effects-and-attitudes-towards-second-donation-a-comparison-of-related-and-unrelated-haematopoietic-stem-cell-donors
#3
Simon Pahnke, Gunnar Larfors, Ulla Axdorph-Nygell, Anne Fischer-Nielsen, Eva Haastrup, Dag Heldal, Maija Itälä-Remes, Jan-Erik Johansson, Marjut Kauppila, Stig Lenhoff, Per Ljungman, Riita Niittyvuopio, Anna Sandstedt, Hans Hägglund
The Nordic Register of Haematopoietic Stem Cell Donors (NRHSD) has registered related and unrelated donors from 10 transplant centres in Sweden, Norway, Finland and Denmark since 1998. We present a prospective, observational study of 1,957 donors, focusing mainly on the differences between related and unrelated donors. Related donors are reported to have more comorbidities, but similar side effects compared with unrelated donors. Side effects after BM or PBSC donation are generally of short duration and in this study no deaths, myocardial infarctions, splenic ruptures, or thromboembolic events are reported...
August 18, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28802068/dietary-citrate-and-plasma-ionized-calcium-implications-for-platelet-donors
#4
Stefanie Haynes, Elda Hickson, Jeanne Linden, Patricia St Pierre, Paula Ducharme, Paula Sulmasy, Linda Welch, Yong Zhao, Mindy Greene, Michelle Vauthrin, Robert Weinstein
BACKGROUND: Platelet donors receive 40 mmol or more of IV citrate anion during donation. When plasma ionized calcium ([Ca(2+) ]) falls by ∼20%, half of the donors report symptoms of hypocalcemic toxicity. Citrus juices contain clinically relevant amounts of citrate anion. We asked whether citrus juice can lower [Ca(2+) ] thus potentially contributing to hypocalcemic toxicity. METHOD: Six volunteers were given 20.4 mmol of citrate anion as grapefruit juice or orange juice...
August 12, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28792089/plasma-exchange-for-the-management-of-refractory-pruritus-of-cholestasis-a-report-of-three-cases-and-review-of-literature
#5
Rati Chkheidze, Ranjit Joseph, James Burner, Karen Matevosyan
BACKGROUND: Intractable pruritus of cholestasis leads to significant morbidity. Therapeutic plasma exchange (TPE) has been shown to be an effective alternative in the setting of refractory pruritus associated with cholestatic liver disease based on several individual reports. Due to rarity of this approach to intractable pruritus, the literature is sparse and therefore TPE, as a treatment for refractory pruritus is currently not in the apheresis guidelines. We present three additional patients with severe intractable pruritus of cholestasis successfully treated with plasma exchange to add to the mounting literature showing this as an effective and safe adjunctive therapy...
August 9, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28766740/formatting-an-experiential-learning-education-module-to-encourage-dysphagia-assessment-in-apheresis-patients
#6
James West, Sonja E Stutzman, Folefac Atem, DaiWai M Olson
BACKGROUND: Dysphagia screening is oftentimes a focus of hospitalized patients, but dysphagia can also occur in outpatient settings. Dysphagia can be overlooked by nurses and clinicians, and it is therefore important to educate nurses on the importance of dysphagia screenings. METHODS: This was a randomized prospective pilot study to compare the effect of experiential learning versus traditional PowerPoint learning regarding nurses' attitudes towards performing dysphagia screening in an outpatient setting...
August 2, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28752901/pegaspargase-induced-hypertriglyceridemia
#7
Aaron Shmookler, Stephen Smith
No abstract text is available yet for this article.
July 28, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28730667/role-of-plasma-exchange-leukocytapheresis-and-plasma-diafiltration-in-management-of-refractory-macrophage-activation-syndrome
#8
Noriko Kinjo, Kazuya Hamada, Chika Hirayama, Masaki Shimizu
Macrophage activation syndrome (MAS) is a life-threating complication of systemic juvenile idiopathic arthritis (s-JIA). Steroid and cyclosporine (CsA) are effective for MAS, but, treatment for steroid- and CsA-resistant patients is still challenging. We report the case of steroid and CsA resistant s-JIA associated MAS misdiagnosed as Kawasaki disease (KD), who was successfully treated with the combination of plasma exchange (PE) and leukocytapheresis (LCAP) followed by plasma diafiltration (PDF). PE + LCAP effectively removed proinflammatory cytokines and reduced the number of peripheral white blood cells...
July 21, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28712132/impact-of-lipoprotein-apheresis-with-dextran-sulfate-adsorption-on-the-expression-of-genes-involved-in-cardiovascular-health-in-the-blood-of-patients-with-homozygous-familial-hypercholesterolemia
#9
Jean-Philippe Drouin-Chartier, André J Tremblay, Jean Bergeron, Nathalie Laflamme, Benoît Lamarche, Patrick Couture
Lipoprotein apheresis (LA) with dextran sulfate adsorption (DSA) is a reliable method to decrease LDL-cholesterol (C) concentrations in patients with homozygous familial hypercholesterolemia (HoFH). The objective of the present study was to investigate the impact of LA with DSA on the mRNA expression of genes associated with cardiovascular health in the whole blood of HoFH patients. Blood samples were collected before and after LA treatment with DSA in 9 HoFH patients. Microarray analyses were performed to measure the whole blood expression of >30 000 annotated genes pre- and post-LA...
July 16, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28699692/granulocyte-colony-stimulating-factor-administration-among-hemoglobin-s-trait-donors-a-single-center-experience-from-the-eastern-mediterranean-region
#10
Cigdem Gereklioglu, Suheyl Asma, Aslı Korur, Songul Tepebası, Pelin Aytan, Mahmut Yeral, Ilknur Kozanoglu, Can Boga, Hakan Ozdogu
BACKGROUND AND OBJECTIVE: Assessment of Hemoglobin S trait donors has gained importance together with the increased allogeneic peripheral stem cell transplant activity for sickle cell disease in the regions where the disease is prevalent. Outcomes of Granulocyte-Colony Stimulating Factor (G-CSF) administration are obscure for hemoglobin S trait donors. This study aims at investigating the incidence of hemoglobin S carrier status and outcomes of G-CSF administration among donors who live in Eastern Mediterranean region...
July 12, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28699649/what-is-the-evidence-to-support-the-use-of-plasma-exchange-as-first-line-therapy-for-n-methyl-d-aspartate-receptor-antibody-encephalitis
#11
LETTER
Eric A Gehrie, Emily A Coberly, Angela Treml, Christopher Tormey, Garrett S Booth
No abstract text is available yet for this article.
July 12, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28653765/a-liquid-calcium-vitamin-d3-supplement-is-effective-prophylaxis-against-hypocalcemic-toxicity-during-apheresis-platelet-donation
#12
Robert Weinstein, Stefanie Haynes, Yong Zhao, Elda Hickson, Jeanne Linden, Patricia St Pierre, Paula Ducharme, Paula Sulmasy, Molly Graves, Jeffrey A Bailey, Linda Welch, Amie Simard, Michelle Vauthrin, Mindy Greene
Hypocalcemic toxicity, because of return of citrate anion to the donor, is the major toxicity of apheresis platelet donation. Oral calcium carbonate, given prophylactically at the start of donation, has shown limited ability to alleviate this toxicity. We examined whether repeated prophylactic doses of calcium carbonate, or of a liquid preparation containing calcium citrate, calcium phosphate, and vitamin D3 , would be more effective at preventing symptoms of hypocalcemic toxicity. Symptoms were reported by 48% of donors who received no prophylaxis and 60% of donors who received 1000 mg of oral calcium carbonate at the start of, and every 20 minutes during, donation (P = 0...
June 27, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28653762/critical-updates-in-the-7-th-edition-of-the-american-society-for-apheresis-guidelines
#13
Tina S Ipe, Huy P Pham, Lance A Williams
The 7(th) edition of the American Society for Apheresis (ASFA) guidelines was composed by an international physicians committee, and includes 14 new diseases, and 2 new indications for diseases described in the former guidelines. Several indications have either changed names or were excluded from this edition. The guidelines are developed after taking into account documented evidence, either supporting or negating use of apheresis technology in the treatment of diseases. Based on this evidence, the committee revises, updates and includes or excludes disease entities/indications in the guidelines...
June 27, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28653757/does-bernard-soulier-syndrome-protect-against-thrombotic-thrombocytopenic-purpura
#14
LETTER
Ryan Jajosky, Michael Toscano, Audrey Jajosky, Natasha Savage
No abstract text is available yet for this article.
June 27, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/27578423/collection-of-hematopoietic-cd34-stem-cells-in-rhesus-macaques-using-spectra-optia
#15
Lynn D Haynes, Jennifer Coonen, Jennifer Post, Kevin Brunner, Debra Bloom, Peiman Hematti, Dixon B Kaufman
BACKGROUND: Nonhuman primates, particularly rhesus macaques, are ideal preclinical large animal models to investigate organ tolerance induction protocols using donor hematopoietic stem cells (HSCs) to induce chimerism. Their relatively small size poses some challenges for the safe and effective collection of peripheral blood HSCs through apheresis procedures. We describe our experiences using the Spectra Optia apheresis unit to successfully obtain HSCs from mobilized peripheral blood of rhesus macaques...
October 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/27583822/babesia-parasitemia-rebound-after-red-blood-cell-exchange
#16
Caroline R Alquist, Zbigniew M Szczepiorkowski, Nancy Dunbar
Babesiosis is an increasingly recognized disease which may benefit from therapeutic apheresis (Category II/Grade 2C). Vulnerable populations include the splenectomized, those aged >50, those with malignancies, and the immunocompromised. In the setting of parasite levels > 10%, significant anemia, renal impairment, pulmonary compromise, or hepatic dysfunction, RBC exchange can rapidly reduce parasite burdens and decrease the bioavailability of proinflammatory cytokines. No previous report has shown such a rapid rebound in parasitemia despite adequate organism removal...
August 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/27578390/plerixafor-as-preemptive-strategy-results-in-high-success-rates-in-autologous-stem-cell-mobilization-failure
#17
Nina Worel, Gerhard Fritsch, Hermine Agis, Alexandra Böhm, Georg Engelich, Gerda C Leitner, Klaus Geissler, Karoline Gleixner, Peter Kalhs, Veronika Buxhofer-Ausch, Felix Keil, Gerhard Kopetzky, Viktor Mayr, Werner Rabitsch, Regina Reisner, Konrad Rosskopf, Reinhard Ruckser, Claudia Zoghlami, Niklas Zojer, Hildegard T Greinix
Plerixafor in combination with granulocyte-colony stimulating factor (G-CSF) is approved for autologous stem cell mobilization in poor mobilizing patients with multiple myeloma or malignant lymphoma. The purpose of this study was to evaluate efficacy and safety of plerixafor in an immediate rescue approach, administrated subsequently to G-CSF alone or chemotherapy and G-CSF in patients at risk for mobilization failure. Eighty-five patients mobilized with G-CSF alone or chemotherapy were included. Primary endpoint was the efficacy of the immediate rescue approach of plerixafor to achieve ≥2...
August 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/27543914/qtc-prolongation-during-peripheral-stem-cell-apheresis-in-healthy-volunteers
#18
Aslı Korur, Ilknur Kozanoglu, Nurhilal Buyukkurt, Mahmut Yeral, Fatih Kandemir, Cigdem Gereklioglu, Cagla Sariturk, Suheyl Asma, Soner Solmaz, Can Boga, Hakan Ozdogu
BACKGROUND AND AIM: Today, voluntary donation of peripheral blood stem cells by healthy donors for allogeneic hemopoietic cell transplantation is common worldwide. Such donations are associated with small but measurable risks of morbidity and mortality. Most complications are associated with citrate infusion during cell collection. We studied the effects of citrate infusion on the QTc and other vital parameters during and after peripheral stem cell apheresis in volunteers. METHOD: To ensure that donors were healthy, screening included taking a detailed medical history, physical examination, and laboratory measurements of plasma calcium and magnesium...
August 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/27531312/-black-cloud-vs-white-cloud-physicians-myth-or-reality-in-apheresis-medicine
#19
Huy P Pham, Dheeraj Raju, Ning Jiang, Lance A Williams
BACKGROUND: Many practitioners believe in the phenomenon of either being labeled a "black cloud" or "white cloud" while on-call. A "white-cloud" physician is one who usually gets fewer cases. A "black-cloud" is one who often has more cases. It is unclear if the designation is only superstitious or if there is some merit. Our aim is to objectively assess this phenomenon in apheresis medicine at our center. METHODS: A one-year prospective study from 12/2014 to 11/2015 was designed to evaluate the number of times apheresis physicians and nurses were involved with emergent apheresis procedures between the hours from 10 PM and 7 AM...
August 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/27531166/red-cell-exchange-for-a-case-of-babesiosis
#20
Heidi D Lehrke, Jeffrey L Winters
No abstract text is available yet for this article.
August 2017: Journal of Clinical Apheresis
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