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Journal of Clinical Apheresis

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https://www.readbyqxmd.com/read/28419561/a-transition-from-using-multi-step-procedures-to-a-fully-integrated-system-for-performing-extracorporeal-photopheresis-a-comparison-of-costs-and-efficiencies
#1
Nabih Azar, Veronique Leblond, Maya Ouzegdouh, Paul Button
INTRODUCTION: The Pitié Salpêtrière Hospital Hemobiotherapy Department, Paris, France, has been providing extracorporeal photopheresis (ECP) since November 2011, and started using the Therakos(®) CELLEX(®) fully integrated system in 2012. This report summarizes our single-center experience of transitioning from the use of multi-step ECP procedures to the fully integrated ECP system, considering the capacity and cost implications. MATERIALS AND METHODS: The total number of ECP procedures performed 2011-2015 was derived from department records...
April 17, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28370399/brisk-clinical-response-to-erythrocytapheresis-in-a-g6pd-deficient-patient-with-rasburicase-induced-methemoglobinemia
#2
LETTER
Laura Cooling
No abstract text is available yet for this article.
April 2, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28370393/removal-of-focal-segmental-glomerulosclerosis-fsgs-factor-supar-using-cytosorb
#3
Heiko Schenk, Janina Müller-Deile, Roland Schmitt, Jan Hinrich Bräsen, Hermann Haller, Mario Schiffer
Treatment of primary focal segmental glomerulosclerosis (FSGS) and its recurrence after kidney transplantation associated with rapid deterioration of kidney function remains to be challenging despite advances in immunosuppressive therapy. The presence of circulating factors has been postulated to be a pivotal player in the pathogenesis of FSGS, although suPAR and CLCF-1 have been identified as the most promising causative factors. The potential therapeutic effect of suPAR elimination in an FSGS patient using CytoSorb, a hemoadsorption device that gained attention in the cytokine elimination in septic patients, was studied...
March 29, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28319287/iatrogenic-thyrotoxicosis-and-the-role-of-therapeutic-plasma-exchange
#4
Kabeer K Shah, Michael M Mbughuni, Edwin A Burgstaler, Darci R Block, Jeffrey L Winters
Thyroid storm or severe thyrotoxicosis results from extreme thyroid hormone elevation. Therapy includes medical management to prevent hormone production, release, recycling, and peripheral conversion while stabilizing adrenergic tone. Thyroid dysfunction is the usual cause but it can be due to excessive thyroid hormone ingestion. Therapeutic plasma exchange (TPE) has been used to rapidly remove protein-bound thyroid hormone. American Society for Apheresis guidelines make a weak recommendation to perform TPE in selected patients in the treatment of thyrotoxicosis based on low quality evidence...
March 20, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28319286/a-successful-model-to-learn-and-implement-ultrasound-guided-venous-catheterization-in-apheresis
#5
Nigopan Gopalasingam, Anna-Marie Eller Thomsen, Lars Folkersen, Peter Juhl-Olsen, Erik Sloth
BACKGROUND: Apheresis treatments can be performed with peripheral venous catheters (PVC), although central venous catheters (CVC) are inserted when PVCs fail or patient with history of difficult vascular access prior to the apheresis. Ultrasound guidance for PVC has shown promising results in other settings. PURPOSE: To investigate if ultrasound guidance for PVC could be implemented among apheresis nurses. Second, how implementation of ultrasound guidance affected the number of CVCs used for apheresis per patient...
March 20, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28304115/extracorporeal-photopheresis-in-pediatric-patients-practical-and-technical-considerations
#6
Robert A DeSimone, Joseph Schwartz, Jennifer Schneiderman
In adults, extracorporeal photopheresis (ECP) is widely utilized for a variety of indications, most commonly cutaneous T-cell lymphoma, acute or chronic graft-versus-host disease (GVHD), solid organ transplant rejection, and other autoimmune and T-cell-mediated disorders. In pediatric patients, the majority of case series and reports have focused on its use in the management of acute and chronic GVHD. Currently utilized ECP technologies were designed for adult patients and there are several challenges in adapting these technologies for use in children...
March 17, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28304106/therapeutic-plasma-exchange-versus-double-plasma-molecular-absorption-system-in-hepatitis-b-virus-infected-acute-on-chronic-liver-failure-treated-by-entercavir-a-prospective-study
#7
Yue-Meng Wan, Yu-Hua Li, Zhi-Yuan Xu, Jing Yang, Li-Hong Yang, Ying Xu, Jin-Hui Yang
BACKGROUND: Therapeutic plasma exchange (TPE) and double plasma molecular absorption system (DPMAS) were two extracorporeal liver support systems. Few studies compared their efficacy profile. OBJECTIVE: This study was to compare the efficacy of TPE and DPMAS on acute-on-chronic liver failure (ACLF) caused by hepatitis B virus (HBV-ACLF). METHODS: 60 HBV-ACLF patients were enrolled and prospectively studied. All patients received entecavir therapy, and were assigned to TPE group (n = 33) and DPMAS group (n = 27)...
March 17, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28295573/therapeutic-plasma-exchange-for-perioperative-management-of-patients-with-congenital-factor-xi-deficiency
#8
Mohamed S Alsammak, Aneel A Ashrani, Jeffrey L Winters, Rajiv K Pruthi
BACKGROUND: Factor XI (FXI) deficiency (hemophilia C [HEM-C]) is a bleeding disorder with unpredictable severity that correlates poorly with FXI coagulation activity (FXI:C). It poses a perioperative hemostatic management challenge. For US patients with severe disease, fresh frozen plasma (FFP) or, in current use, thawed plasma is the most readily available option but comes with risk of volume overload. We report our experience of using therapeutic plasma exchange (TPE) as an alternative perioperative management strategy...
March 15, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28247959/therapeutic-plasma-exchange-in-chronic-dysimmune-peripheral-neuropathies-a-10-year-retrospective-study
#9
Philippe Codron, Maud Cousin, Jean-François Subra, Vivien Pautot, Franck Letournel, Christophe Verny, Julien Cassereau
INTRODUCTION: Therapeutic plasma exchange (TPE) can be proposed in the treatment of chronic dysimmune peripheral neuropathies (CDPN). Actual guidelines are however based on few studies, and indications and protocols still remain to be clarified. We conducted a 10-year retrospective study in order to assess the effectiveness and tolerance of TPE in CDPN. METHODS: All patients treated for CDPN with TPE from October 2006 to March 2016 in the university hospital of Angers were included...
March 1, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28181293/comparison-of-two-double-red-cell-collection-settings-on-fenwal-alyx-apheresis-instrument
#10
Edwin A Burgstaler, Kimberly J Duffy, Manish J Gandhi
The Fenwal Alyx for collecting double red cell products has two red cell volume collection settings: fixed collection target of 360 ml (180 ml/unit) and a variable target of collecting either 400 or 360 ml (200 or 180 ml/unit), where the machine aims for the higher possible collection target. We retrospectively compared the two collection targets for the RBC content, donor time, technician time, and collection efficiency. We compared 18 fixed (F) target collections to 40 variable (V) target collections. All collections were performed as per the manufacturer's recommendations on Alyx and donors met the manufacturer's eligibility criteria...
February 9, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28171695/pre-emptive-plerixafor-injection-in-lymphoma-patients-mobilized-with-chemotherapy-plus-pegfilgrastim-followed-by-apheresis-on-the-same-day
#11
LETTER
E Jantunen, A Partanen, J Valtola, M Pyörälä, P Mäntymaa, T Nousiainen, V Varmavuo
No abstract text is available yet for this article.
February 7, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28168781/therapeutic-exchange-with-reconstituted-whole-blood-using-plasma-exchange-kit-on-a-cell-separator-in-g6pd-deficient-patient-requiring-red-cell-exchange-for-methemoglobinemia
#12
LETTER
Satya Prakash, Rekha Hans, Ratti Ram Sharma, Neelam Marwaha, Ritesh Agarwal
No abstract text is available yet for this article.
February 7, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28168723/chronic-transfusion-therapy-for-stroke-in-sickle-cell-disease
#13
LETTER
Michael R DeBaun, Keith Quirolo
No abstract text is available yet for this article.
February 6, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28146331/plasma-exchange-in-the-intensive-care-unit-technical-aspects-and-complications
#14
Aurélie Lemaire, Nathalie Parquet, Lionel Galicier, David Boutboul, Rémi Bertinchamp, Marion Malphettes, Guillaume Dumas, Eric Mariotte, Marie-Noëlle Peraldi, Virginie Souppart, Benoit Schlemmer, Elie Azoulay, Emmanuel Canet
BACKGROUND: Data on plasma exchange therapy in the intensive care unit (ICU) setting are scarce. We aimed to describe the technical aspects and the adverse events associated with the procedure in critically ill patients. METHODS: All adult patients treated by plasma exchange in the medical ICU of the Saint-Louis university hospital between January 1, 2013 and March 31, 2015 were prospectively included. RESULTS: We report on 260 plasma exchange procedures performed in 50 patients...
February 1, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28139098/predictors-for-successful-pbsc-collection-on-the-fourth-day-of-g-csf-induced-mobilization-in-allogeneic-stem-cell-donors
#15
Anja van Oostrum, Jaap Jan Zwaginga, Sandra Croockewit, Jacqueline Overdevest, Mirjam Fechter, Bart Ruiterkamp, Anneke Brand, Tanja Netelenbos
Peripheral blood stem cells (PBSCs) used for allogeneic transplantation are collected by apheresis after pre-treatment of donors with G-CSF. Using modern apheresis devices stem cells can be collected more efficiently. It was studied whether collection on the 4th instead of the 5th day after initiation of G-CSF treatment might be feasible. Stem cell yields that could have been collected on day 4 were calculated in two cohorts treated with 10 µg/kg G-CSF once daily (n = 106, cohort I) or 5 µg/kg twice daily schedule (n = 85, cohort II)...
January 31, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28139007/case-report-of-male-child-with-elevated-lipoprotein-a-leading-to-acute-ischemic-stroke
#16
Patrick M Moriarty, Heather Tennant, Nandhini Sehar, Lauryn Denney, Paola Luna, Francesca Perez-Marques, Apurva Panchal, Michael Abraham, John Leever
Acute ischemic stroke (AIS) in children is rare with almost 40% diagnosed as cryptogenic. One possible mechanism associated with AIS is an elevated Lipoprotein (a) [Lp(a)] level. Here, we discuss the case of an 11-year old boy who presented with multiple thrombotic strokes secondary to elevated Lp(a), which was identified as the only risk factor and immediately treated with lipoprotein apheresis (LA). Eighteen months post-AIS, he is still receiving LA treatments and has made remarkable progress in his recovery without another cerebrovascular event...
January 31, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28411399/special-issue-abstracts-from-the-american-society-for-apheresis-38-th-annual-meeting-may-3-6-2017-fort-lauderdale-florida
#17
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/27119769/a-perfect-storm-tumor-lysis-syndrome-with-rasburicase-induced-methemoglobinemia-in-a-g6pd-deficient-adult
#18
LETTER
Kathleen W Montgomery, Garrett S Booth
No abstract text is available yet for this article.
February 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/27112240/red-cell-exchange-to-mitigate-a-delayed-hemolytic-transfusion-reaction-in-a-patient-transfused-with-incompatible-red-blood-cells
#19
Mehraboon S Irani, Matthew S Karafin, Luke Ernster
PURPOSE: A red cell exchange was performed to prevent a potentially fatal hemolytic transfusion reaction in a patient with anti-e who was transfused with e-antigen unscreened red blood cells during liver transplant surgery. CASE REPORT: A 64-year-old woman with cirrhosis due to hepatitis C was scheduled to receive a liver transplant. She had a previously documented anti-e, an antibody to the Rh(e)-antigen that is known to cause delayed hemolytic transfusion reactions...
February 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/27095367/comparison-between-intermittent-and-continuous-spectra-optia-leukapheresis-systems-for-autologous-peripheral-blood-stem-cell-collection
#20
COMPARATIVE STUDY
Katharina Lisenko, Petra Pavel, Thomas Bruckner, Joe Puthenparambil, Michael Hundemer, Anita Schmitt, Mathias Witzens-Harig, Anthony D Ho, Patrick Wuchter
Terumo BCT recently introduced a new system for mononuclear cell (MNC) collection that uses a Spectra Optia apheresis machine equipped with a redesigned disposable kit and software program (version 11.2). It allows for the continuous collection of MNCs, unlike the original Spectra Optia system (version 7.2), which included a chamber for two-step cell separation. The aim of this study was to compare the two apheresis systems in regard to specific performance parameters. A retrospective data analysis of 150 patients who had undergone peripheral blood stem cell collection between March of 2014 and May of 2015 at our institution was performed...
February 2017: Journal of Clinical Apheresis
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