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Journal of Clinical Apheresis

Alexa J Siddon, Edward L Snyder, Christopher A Tormey
No abstract text is available yet for this article.
September 22, 2018: Journal of Clinical Apheresis
Nicole D Zantek, Leonard I Boral, Yanhua Li, Chisa Yamada, Annika M Svensson, Jason E Crane, Roy E Smith, Monica B Pagano, Marian A Rollins-Raval, Amy E Schmidt, Edward C C Wong, Yanyun Wu
BACKGROUND: Patients undergoing therapeutic plasma exchange (TPE) may present with risks for hemorrhage or thrombosis. Use of replacement fluids devoid of coagulation factors will decrease factor levels and platelet levels. There are no established guidelines for hemostasis management in these situations. MATERIALS AND METHODS: A survey to evaluate current hemostasis management practice during TPE was conducted using online survey software. One response per institution was analyzed based on a hierarchical algorithm, excluding membrane filtration users, resulting in a maximum of 107 respondents...
September 12, 2018: Journal of Clinical Apheresis
Yoshihisa Miyamoto, Yoshifumi Hamasaki, Akihiko Matsumoto, Kent Doi, Eisei Noiri, Masaomi Nangaku
BACKGROUND: Plasma exchange (PE) and double filtration plasmapheresis (DFPP) are known as effective treatment options for hyperviscosity syndrome (HVS) caused by Waldenstrom macroglobulinemia. Nonetheless, few data are available for the relation between the prescribed dose of apheresis and the reduction rate of target molecule immunoglobulin M (IgM), especially in the modality using membrane separation. OBJECTIVES: This study was conducted to establish a model to predict the IgM reduction rate by the dose of simple PE and DFPP using membrane separation in patients with HVS and to compare the consumption of albumin between PE and DFPP...
September 6, 2018: Journal of Clinical Apheresis
Rasheed A Balogun, Joseph Schwartz, Nancy Dunbar, Anand Padmanabhan
No abstract text is available yet for this article.
September 6, 2018: Journal of Clinical Apheresis
Rebecca Dill, DaiWai M Olson, Nellie Session-Augustine, Dara Mariani, Sonja E Stutzman
BACKGROUND: Autoimmune disorders and neurodegenerative disorders take a physical and emotional toll on patients that undergo therapeutic plasma exchange (TPE) treatments. Previous literature has shown that these patients may feel a greater sense of self-burden. Motivational Interviewing (MI) is a technique used in various settings that has the potential to decrease feelings of self-burden. MI for patients who receive TPE has not been tested. The purpose of this study was to examine the impact of MI in patients with a neurodegenerative diagnosis (eg, transverse myelitis, myasthenia gravis, multiple sclerosis, and chronic inflammatory demyelinating polyneuropathy) that are undergoing TPE treatments...
September 3, 2018: Journal of Clinical Apheresis
Elizabeth M Staley, Dheeraj Raju, Lance A Williams, Chong H Kim, Ning Jiang, Huy P Pham
Many practitioners believe in the phenomenon of being labeled either a "black cloud" or "white cloud" while on-call. A "white-cloud" physician is usually defined as one who sees fewer cases while a "black-cloud" is one who often receives more cases. To evaluate these phenomena, a 35-month prospective study was designed to evaluate the number of times apheresis staff was involved with emergent apheresis procedures at a large institution in the off hours between 10 pm and 7 am, since this is the time period when significant resources have to be mobilized to perform the procedure...
September 3, 2018: Journal of Clinical Apheresis
Maja-Theresa Dieterlen, Jens Garbade, Martin Misfeld, Sven Lehmann, Kristin Klaeske, Michael A Borger, Markus J Barten
BACKGROUND: The clinical use of extracorporeal photopheresis (ECP) is based on its ability to induce cell-mediated immune tolerance towards foreign and self-antigens. Up-to-date, no clear consensus consists on how to use ECP after heart transplantation (HTx). In this pilot study, we evaluated the stimulatory effects of ECP on immune cells in HTx patients. METHODS: HTx patients received ECP therapy as prophylaxis of rejection (PRX, n = 15), to treat acute cellular rejection (ACR, n = 13) or cardiac allograft vasculopathy (CAV, n = 5)...
September 3, 2018: Journal of Clinical Apheresis
Osman Yesilbas, Esra Sevketoglu, Mey Talip Petmezci, Hasan Serdar Kihtir, Meryem Benzer, Cigdem Arikan, Afig Berdeli, Huseyin Baloglu, Ozdil Baskan
No abstract text is available yet for this article.
August 30, 2018: Journal of Clinical Apheresis
Yong Zhao, Jeanne Linden, Linda Welch, Patricia St Pierre, Molly Graves, Danielle Garrity, Paula Ducharme, Jeffrey A Bailey, Mindy Greene, Michelle Vauthrin, Robert Weinstein
We compared two methods of calcium gluconate infusion to maintain plasma ionized calcium ([Ca2+ ]) during therapeutic plasma exchange (TPE) performed using the Spectra Optia Apheresis System. Method A, our legacy method, consisted of adding 5 mL of 10% calcium gluconate to each 500 mL bottle of 5% albumin replacement fluid. Method B used an accessory IV infusion of calcium gluconate (2 g in 50 mL of 0.9% NaCl starting at 25 mL/h). Plasma [Ca2+ ] was measured at 20-minute intervals, and symptoms of hypocalcemia were recorded during TPE...
August 11, 2018: Journal of Clinical Apheresis
Eun Seok Choi, Ho Joon Im, Hyery Kim, Kyung Nam Koh, Seongsoo Jang, Chan-Jeoung Park, Jong Jin Seo, Ho Ran Park
A consistent and reproducible depletion technique is crucial for the successful transplantation of an ex vivo depleted graft. Our aim was to evaluate the efficacy of an ex vivo technique for depletion of αβ+ T cells using a biotinylated anti-TCRαβ monoclonal antibody, which was performed by one clinical nurse specialist. Between 2012 and 2017, 119 depletion procedures from 216 apheresis using the anti-TCRαβ monoclonal antibody were performed on 105 pediatric patients. The median log depletion of αβ+ T cells was 4...
August 2018: Journal of Clinical Apheresis
Alexis R Peedin, Julie K Karp
No abstract text is available yet for this article.
August 2018: Journal of Clinical Apheresis
Jay S Raval, Nora R Ratcliffe
No abstract text is available yet for this article.
August 2018: Journal of Clinical Apheresis
Ayumi Ito, Teppei Omori, Norio Hanafusa, Ken Tsuchiya, Shinichi Nakamura, Katsutoshi Tokushige
BACKGROUND: Elderly ulcerative colitis (UC) is increasing. Elderly UC differ from younger UC with respect to the course of their disease. Granulocyte adsorption apheresis (CAP) is often used to treat elderly UC. We retrospectively analyzed the cases of elderly UC who underwent CAP for remission induction therapy in a comparison with younger UC. METHODS: 96 patients with UC underwent CAP. Patients who concurrently received tacrolimus, biological agents, or high-dose steroid therapy were excluded...
August 2018: Journal of Clinical Apheresis
M G Zenti, C Stefanutti, V Sanga, A Altomari, A Fabris, M Dauriz, E Bonora
A 49 years old woman (weight 68 kg, BMI 27.3 kg/m2 ) with heterozygous familial hypercholesterolemia (HeFH) and multiple statin intolerance with muscle aches and creatine kinase elevation, presented at the Outpatient Lipid Clinic of Verona University Hospital in May 2015. Hypercholesterolemia was firstly diagnosed during adolescence, followed in adulthood by a diagnosis of Cogan's syndrome, a rheumatologic disorder characterized by corneal and inner ear inflammation. No xanthomas, corneal arcus, or vascular bruits were detectable at physical examination...
August 2018: Journal of Clinical Apheresis
Soumya Pandey, Michele Cottler-Fox
PURPOSE: We evaluated the Optia® continuous mononuclear collection (CMNC) system for hematopoietic progenitor cell-apheresis (HPC-A) collection (Terumo BCT, Lakewood, CO) compared to the COBE® Spectra (Terumo BCT, Lakewood, CO), including both large volume leukapheresis (LVL) and non-LVL collections. METHODS: We performed a retrospective data analysis of all autologous HPC-A collections with the Optia® CMNC system (n = 93; LVL = 59, non-LVL = 34) since implementation at our institution and compared it with a similar number of concurrent collections utilizing the COBE® Spectra (n = 96; LVL = 68, non-LVL = 28)...
August 2018: Journal of Clinical Apheresis
Josef Evers, Uwe Taborski
This article is based on a question of a colleague from North America how coagulation could be triggered between a donor's arm and a fistula needle during plasma donation (synonymous with donor plasmapheresis). The technique of venipuncture and citrate anticoagulation are described. Uncommon and rare problems such as prolonged bleeding, scarring, and thrombosis in plasma donors are discussed. If venous puncture and citrate: blood flow ratio at 1:16 are correctly performed, however, there will be no anticoagulation abnormalities due to plasma donation...
August 2018: Journal of Clinical Apheresis
Richard Edelson, Yanyun Wu, Jennifer Schneiderman
Stimulated by the scientific progress in deciphering the principal elements contributing to the clinical efficacy of extracorporeal photochemotherapy (ECP), the American Council on ECP (ACE) was formed, under the auspices of the American Society for Apheresis (ASFA), to develop a field-guiding Consensus Report. ACE is composed of thirty nationally recognized ECP experts, clinically spanning cancer, transplantation, and autoimmunity and scientifically bridging immunology, bioengineering, and hematology. The two-day meeting took place in Manhattan, April 13-14, 2017, and unanimous consensus on nine pivotal points is herein reported...
August 2018: Journal of Clinical Apheresis
Patrick Kuhlman, Peter Miller, Andrew Farland, John Owen, Katharine Batt
Acute thrombotic thrombocytopenic purpura (TTP) is an aggressive thrombotic microangiopathy that if not treated, can have a 90% mortality rate. Clinical manifestations of this disease include profound thrombocytopenia, hemolytic anemia, and end-organ dysfunction. Neurologic symptoms can occur in 80% of patients and range from mild confusion to coma (Scully et al., Br J Haematol 142:819-826). Here, we present the clinical course of a patient diagnosed with new onset acquired TTP who presented with neurologic changes that waxed and waned during her disease course...
August 2018: Journal of Clinical Apheresis
Nalu Navarro-Alvarez, Beatriz Goncalves, Alec R Andrews, Zhaohui Wang, Zhirui Wang, Edward Harrington, Jigesh Shah, David H Sachs, Isaac Eliaz, Christene A Huang
Galectin-3 (Gal-3), a β-galactoside-binding lectin that is expressed in mammalian cells, is known to modulate several biological functions such as cell-cell adhesion, macrophage activation, angiogenesis, metastasis, and fibrosis. The goal of this study was to evaluate the ability of Gal-3 depletion apheresis using an adsorption column with immobilized anti-Gal-3-antibody to reduce inflammation induced by Complete Freund's Adjuvant injection in a skin inflammation porcine model. Here, we report that plasma perfusion by apheresis through a Gal-3 binding immuno-affinity column reduces plasma Gal-3 levels to below limits of quantitative detection, and results in significant decrease in skin inflammation, including degree and duration of inflammatory lesions...
August 2018: Journal of Clinical Apheresis
Nelly Besson, Mie Topholm Bruun, Thomas Stauffer Larsen, Christian Nielsen
Success of peripheral blood stem cell (PBSC) collections depends on patient biological parameters and stable apheresis device performance. We investigated product quality and factors influencing main apheresis procedure outcomes including CD34+ collection efficiency (CE), product volume or platelet CE. We also assessed different CD34+ cell yield prediction algorithms. Autologous PBSC collections by Spectra Optia from myeloma and lymphoma patients were analyzed. Complete blood count (CBC) from patient preprocedure and from collected products were assessed...
August 2018: Journal of Clinical Apheresis
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