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Cornea

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https://www.readbyqxmd.com/read/28914634/cellular-therapy-with-human-autologous-adipose-derived-adult-stem-cells-for-advanced-keratoconus
#1
Pragnya R Donthineni, Bhupesh Bagga, Vivek Singh, Sachin Shukla
No abstract text is available yet for this article.
September 12, 2017: Cornea
https://www.readbyqxmd.com/read/28914633/gaps-in-current-knowledge-and-priorities-for-future-research-in-dry-eye
#2
Ian J Saldanha, Kay Dickersin, Susan T Hutfless, Esen K Akpek
PURPOSE: Dry eye, a common yet underrecognized and evolving field, has few recommended treatment algorithms, mostly based on expert consensus rather than robust research evidence. There are high costs associated with managing dry eye and conducting research to identify effective and safe long-term treatments. To support evidence-based management of dry eye, our purpose was to identify and prioritize important clinical research questions for future clinical research. METHODS: We translated recommendations from the American Academy of Ophthalmology's 2013 Preferred Practice Patterns for dry eye into answerable clinical research questions about treatment effectiveness...
September 12, 2017: Cornea
https://www.readbyqxmd.com/read/28914632/stepwise-guided-photorefractive-keratectomy-in-treatment-of-irregular-astigmatism-after-penetrating-keratoplasty-and-deep-anterior-lamellar-keratoplasty
#3
Nir Sorkin, Adi Einan-Lifshitz, Sagi Abelson, Tanguy Boutin, Mahmood Showail, Armand Borovik, Zach Ashkenazy, Clara C Chan, David S Rootman
PURPOSE: To report the outcome of stepwise ablation using topography-guided photorefractive keratectomy to treat irregular astigmatism after either penetrating keratoplasty (PKP) or deep anterior lamellar keratoplasty (DALK). METHODS: This is a retrospective, interventional analysis including patients with irregular astigmatism after either PKP or DALK, who underwent topography-guided photorefractive keratectomy. The entire cohort was analyzed, as well as the PKP and DALK groups separately...
September 12, 2017: Cornea
https://www.readbyqxmd.com/read/28902722/diagnostic-approach-to-ocular-infections-using-various-techniques-from-conventional-culture-to-next-generation-sequencing-analysis
#4
Hiroshi Eguchi, Fumika Hotta, Tomomi Kuwahara, Haruyuki Imaohji, Chika Miyazaki, Miou Hirose, Shunji Kusaka, Masahiko Fukuda, Yoshikazu Shimomura
Ocular infection is caused by both endogenous (resident) and exogenous (environmental) microbes. As the ocular surface interacts with both outer environment and its own resident microbiota, clinical ocular samples are predicted to contain a diverse set of microorganisms. Microscopy of sample smears is an important step in the diagnostic process of infectious diseases to interpret the culture results. Traditional culture techniques have several limitations in the detection and/or identification of uncharacterized bacteria of environmental origin...
September 11, 2017: Cornea
https://www.readbyqxmd.com/read/28902014/reply
#5
Mohsen Pourazizi, Abdolhossein Ghafourian
No abstract text is available yet for this article.
September 8, 2017: Cornea
https://www.readbyqxmd.com/read/28902013/-bubble-in-the-roll-technique-using-the-endoject-dmek-injector-influence-of-the-air-bubble-on-endothelial-cell-loss
#6
Yasemin Akbaba, Julia M Weller, Kathrin Rössler, W John Armitage, Ursula Schlötzer-Schrehardt, Friedrich E Kruse, Theofilos Tourtas
PURPOSE: To evaluate the impact of the air bubble on endothelial cell loss using the "bubble-in-the-roll" technique during Descemet membrane endothelial keratoplasty (DMEK). METHODS: Twenty DMEK grafts not suitable for transplantation were manually prepared from organ-cultured corneoscleral discs and injected into culture media using the Endoject DMEK injector (Medicel AG, Wolfhalden, Switzerland). Based on the injection method, the grafts were divided into 2 groups: In group A (n = 10), a small air bubble was placed inside the graft roll while it was in the injector...
September 8, 2017: Cornea
https://www.readbyqxmd.com/read/28902012/comparison-of-oral-voriconazole-versus-oral-ketoconazole-as-an-adjunct-to-topical-natamycin-in-severe-fungal-keratitis-a-randomized-controlled-trial
#7
Namrata Sharma, Deepali Singhal, Prafulla K Maharana, Rajesh Sinha, Tushar Agarwal, Ashish D Upadhyay, Thirumurthy Velpandian, Gita Satpathy, Jeewan S Titiyal
PURPOSE: To compare the efficacy of oral voriconazole (VCZ) with oral ketoconazole (KCZ) as an adjunct to topical natamycin in severe fungal keratitis. METHODS: Fifty eyes of 50 patients with proven severe fungal keratitis, (>5 mm size, involving >4 mm central cornea and >50% stromal depth), smear, and/or culture positive were randomized to receive either oral VCZ (n = 25) or oral KCZ (n = 25) 200 mg twice a day. Both groups received topical natamycin along with oral medication...
September 8, 2017: Cornea
https://www.readbyqxmd.com/read/28902011/meibomian-gland-dysfunction-associated-with-periocular-radiotherapy
#8
Young Jun Woo, JaeSang Ko, Yong Woo Ji, Tae-Im Kim, Jin Sook Yoon
PURPOSE: To investigate the influence of periocular radiotherapy on meibomian glands. METHODS: We evaluated 28 patients (40 eyes) who received radiotherapy (RT group) for conjunctival or orbital lymphoma and 30 age-matched control subjects (60 eyes). Subjects underwent slit-lamp examination of the eyelids, Schirmer test, meibography, and evaluation of tear film breakup time (TBUT), Ocular Surface Disease Index (OSDI) scores, meibomian glands evaluation (meiboscore, meibum expressibility, and lid margin abnormality scores), and tear film lipid layer thickness using an ocular surface interferometer...
September 8, 2017: Cornea
https://www.readbyqxmd.com/read/28902010/posterior-amorphous-corneal-dystrophy-associated-with-keratoglobus-a-case-report
#9
Jonathan Fay, Alexandra A Herzlich, George J Florakis
PURPOSE: Posterior amorphous corneal dystrophy (PACD) is a rare disorder characterized by sheet-like opacification of the posterior corneal stroma, corneal thinning, and decreased corneal curvature. It is not known to be associated with progressive corneal ectasia. In this report, we examine the course of a patient with PACD who developed bilateral keratoglobus-type corneal ectasia. METHODS: The clinical history of a single patient is reviewed from birth through age 15...
September 8, 2017: Cornea
https://www.readbyqxmd.com/read/28902018/mechanism-of-proliferation-of-cultured-human-corneal-endothelial-cells
#10
Takeshi Joko, Atsushi Shiraishi, Takeshi Kobayashi, Yuichi Ohashi, Shigeki Higashiyama
Because human corneal endothelial cells (HCECs) do not proliferate once the endothelial monolayer has formed, corneal wound healing is believed to be mediated by cell enlargement or migration, rather than by proliferation. However, the cellular mechanisms involved in wound healing by HCECs have not been fully determined. In this review, we focus on the effects of promyelocytic leukemia zinc finger (PLZF), a DNA-binding transcription factor, and transforming growth factor (TGF)-β2 on the proliferation and migration of cultured HCECs...
September 7, 2017: Cornea
https://www.readbyqxmd.com/read/28902017/ocular-demodicosis-as-a-potential-cause-of-ocular-surface-inflammation
#11
Xiaohui Luo, Jing Li, Chuan Chen, Scheffer Tseng, Lingyi Liang
Among different species of mites, Demodex folliculorum and Demodex brevis are the only 2 that affect the human eye. Because demodicosis is highly age-dependent and can be found in asymptomatic adults, the pathogenicity of these mites has long been debated. In this study, we summarize our research experience including our most recent study regarding Demodex infestation as a potential cause of ocular inflammatory diseases. Specifically, we describe the pathogenesis of demodicosis and then discuss the results of work investigating the associations and relationships between ocular demodicosis and blepharitis, meibomian gland diseases, and keratitis, in turn...
September 7, 2017: Cornea
https://www.readbyqxmd.com/read/28902016/raman-microscopy-a-noninvasive-method-to-visualize-the-localizations-of-biomolecules-in-the-cornea
#12
Yuichi Kaji, Toshihiro Akiyama, Hiroki Segawa, Tetsuro Oshika, Hideaki Kano
PURPOSE: In vivo and in situ visualization of biomolecules without pretreatment will be important for diagnosis and treatment of ocular disorders in the future. Recently, multiphoton microscopy, based on the nonlinear interactions between molecules and photons, has been applied to reveal the localizations of various molecules in tissues. We aimed to use multimodal multiphoton microscopy to visualize the localizations of specific biomolecules in rat corneas. METHODS: Multiphoton images of the corneas were obtained from nonlinear signals of coherent anti-Stokes Raman scattering, third-order sum frequency generation, and second-harmonic generation...
September 7, 2017: Cornea
https://www.readbyqxmd.com/read/28902015/-progress-in-corneal-research-and-practice-in-japan-and-abroad-22nd-annual-meeting-of-the-kyoto-cornea-club-november-25-and-26-2016
#13
Kohji Nishida, Chie Sotozono, Satoru Yamagami, Atsushi Shiraishi, Shizuya Saika, Atsuki Fukushima, Yuichi Hori
No abstract text is available yet for this article.
September 7, 2017: Cornea
https://www.readbyqxmd.com/read/28872521/knowledge-and-attitude-toward-corneal-donation-among-high-school-children-in-northern-india
#14
Manisha Acharya, Deepali Chaku, Abhishek Dave, Animesh Das, Nikunj V Patel
No abstract text is available yet for this article.
August 31, 2017: Cornea
https://www.readbyqxmd.com/read/28872520/descemet-membrane-endothelial-keratoplasty-patch-for-persistent-corneal-hydrops
#15
Elmer Y Tu
PURPOSE: To report successful management of a case of persistent keratoconus-related hydrops with a Descemet membrane endothelial keratoplasty (DMEK) patch graft. METHODS: A case of corneal hydrops persisting for 7 months treated with DMEK was identified. The following information was collected: demographic data, surgical indications, clinical course, diagnostic tests, and clinical outcome. RESULTS: A 55-year-old patient with an established diagnosis of keratoconus was followed for 7 months without improvement in his acute corneal hydrops...
August 31, 2017: Cornea
https://www.readbyqxmd.com/read/28872519/changes-in-corneal-density-after-accelerated-corneal-collagen-cross-linking-with-different-irradiation-intensities-and-energy-exposures-1-year-follow-up
#16
Semra Akkaya Turhan, Ebru Toker
PURPOSE: To determine and compare the changes in corneal density after 2 different protocols of accelerated corneal collagen cross-linking (A-CXL) in patients with progressive keratoconus. METHODS: Two groups of eyes received A-CXL treatment; 20 eyes received A-CXL using continuous UVA light exposure at 9 mW/cm for 10 minutes with a total energy dose of 5.4 J/cm, and 24 eyes received A-CXL using continuous UVA light exposure at 30 mW/cm for 4 minutes with a total energy dose of 7...
August 31, 2017: Cornea
https://www.readbyqxmd.com/read/28872518/tear-osmolarity-and-correlation-with-ocular-surface-parameters-in-patients-with-dry-eye
#17
Priya M Mathews, Sezen Karakus, Devika Agrawal, Holly B Hindman, Pradeep Y Ramulu, Esen K Akpek
PURPOSE: To analyze the distribution of tear film osmolarity in patients with dry eye and its association with other ocular surface parameters. METHODS: Tear osmolarity and other quantitative dry eye parameters were obtained from patients with 1) clinically significant dry eye (significant symptoms and ocular surface staining, n = 131), 2) symptoms-only dry eye (significant symptoms but no significant ocular surface staining, n = 52), and 3) controls (no significant symptoms or staining, n = 42)...
August 31, 2017: Cornea
https://www.readbyqxmd.com/read/28872517/favorable-outcome-in-coccidioides-endophthalmitis-a-combined-medical-and-surgical-treatment-approach
#18
Jennifer J Ling, Derek J Bays, George R Thompson, Ala Moshiri, Mark J Mannis
PURPOSE: To describe a case of Coccidioides endophthalmitis that resulted in a favorable visual outcome after a combined medical and surgical approach. METHODS: A 33-year-old previously healthy woman was referred for evaluation of dyspnea and left-sided vision loss, which began 3 months before, after a trip to Nevada. She was found to have a pulmonary cavitary lesion and fluffy white material in the anterior chamber. An aqueous and vitreous paracentesis grew Coccidioides species...
August 31, 2017: Cornea
https://www.readbyqxmd.com/read/28872516/corneal-densitometry-in-healthy-corneas-and-its-correlation-with-endothelial-morphometry
#19
Kemal Tekin, Mehmet Ali Sekeroglu, Hasan Kiziltoprak, Pelin Yilmazbas
PURPOSE: To evaluate the correlations between corneal endothelial cell properties and corneal densitometry values and to investigate whether corneal densitometry may be used as an indicator of the health of corneal endothelium. METHODS: Two hundred fifty-three eyes were analyzed in this prospective cross-sectional study. Corneal densitometry was measured with densitometry software of Pentacam HR-Scheimpflug corneal topography over a 12-mm diameter of the cornea...
August 31, 2017: Cornea
https://www.readbyqxmd.com/read/28837530/visual-outcomes-after-smile-lasek-and-lasek-combined-with-corneal-cross-linking-for-high-myopic-correction
#20
Montserrat Garcia-Gonzalez, Miguel A Teus, Juan Gros-Otero
No abstract text is available yet for this article.
August 23, 2017: Cornea
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