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Cornea

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https://www.readbyqxmd.com/read/28644241/long-term-ocular-surface-stability-in-conjunctival-limbal-autograft-donor-eyes
#1
Albert Y Cheung, Enrica Sarnicola, Edward J Holland
PURPOSE: To investigate the incidence of limbal stem cell deficiency (LSCD) in donor eyes after conjunctival limbal autograft (CLAU). METHODS: An observational retrospective review was performed on all patients who underwent CLAU alone, combined keratolimbal allograft with CLAU ("Modified Cincinnati Procedure"), or combined living-related conjunctival limbal allograft (lr-CLAL) with CLAU having ≥6 months of follow-up after surgery. The outcome measures were best-corrected visual acuity (BCVA) and ocular surface status...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28644240/corneal-stiffening-by-a-bacteriochlorophyll-derivative-with-dextran-and-near-infrared-light-effect-of-shortening-irradiation-time-up-to-1-minute
#2
Jurriaan Brekelmans, Alexandra Goz, Mor M Dickman, Alexander Brandis, Xiaomeng Sui, H Daniel Wagner, Rudy M M A Nuijts, Avigdor Scherz, Arie L Marcovich
PURPOSE: The aim of this study is to determine the effect of variation of the exposure time of near-infrared irradiation on corneal stiffening after a bacteriochlorophyll derivative (WST11) with dextran (WST-D) application. METHODS: One hundred four paired eyes of 3-month-old New Zealand White rabbits were included in this study. Fifty-two eyes (ex vivo n = 34, in vivo n = 18) were mechanically deepithelialized, treated topically with WST-D, and irradiated at 10 mW/cm using a diode laser at 755 nm for 1, 5, or 30 minutes...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28644239/effect-of-the-learning-curve-on-visual-and-refractive-outcomes-of-small-incision-lenticule-extraction
#3
Tommy C Y Chan, Alex L K Ng, George P M Cheng, Victor C P Woo, Jiamei Zhang, Yan Wang, Vishal Jhanji
PURPOSE: To investigate the effect of the learning curve for small-incision lenticule extraction during the first 2 years of experience. METHODS: Small-incision lenticule extraction was performed using the 500-kHz VisuMax femtosecond laser (Carl Zeiss Meditec) by the same surgeon. The initial 100 patients since the surgeon started operating independently were considered as group 1; the recent 100 patients were considered as group 2. The same laser settings and technique were used...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28644238/prevention-and-management-of-descemet-membrane-endothelial-keratoplasty-complications
#4
Ruth Quilendrino, Marina Rodriguez-Calvo de Mora, Lamis Baydoun, Lisanne Ham, Korine van Dijk, Isabel Dapena, Silke Oellerich, Gerrit R J Melles
PURPOSE: To describe Descemet membrane endothelial keratoplasty (DMEK) complications and strategies for their prevention and management. METHODS: Five hundred consecutive eyes with DMEK of 393 patients were reviewed in this retrospective study for intraoperative and postoperative complications up to 2 years and for corresponding management. RESULTS: Intraoperative challenges (difficult graft unfolding/positioning, high vitreous pressure, iris root hemorrhage, and Descemet membrane remnants) were encountered in 81 eyes (16...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28644237/outcomes-of-keratoplasty-after-ocular-surface-stem-cell-transplantation
#5
Lorena Sepsakos, Albert Y Cheung, Edward J Holland
PURPOSE: To investigate the long-term outcomes of penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) after ocular surface stem cell transplantation (OSST). METHODS: An observational retrospective review was performed on all patients who underwent OSST followed by either PK or DALK with a minimum of 6-month follow-up. RESULTS: One hundred two eyes fulfilled the inclusion criteria. The mean time to keratoplasty after OSST was 19 months, and the mean follow-up was 57 months after keratoplasty...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28644236/cyp1b1-cytopathy-uncommon-phenotype-of-a-homozygous-cyp1b1-deletion-as-internal-corneal-ulcer-of-von-hippel
#6
Valeria Oliva-Biénzobas, Alejandro Navas, Mirena C Astiazarán, Oscar Francisco Chacón-Camacho, Jose A Bermúdez-Magner, Mariana Takane, Enrique Graue-Hernández, Juan Carlos Zenteno
PURPOSE: To report a mutation of CYP1B1 in a newborn with a rare phenotype without the classic features of anterior segment dysgenesis or congenital glaucoma. METHODS: The newborn presented with diffuse corneal edema and bilaterally elevated intraocular pressure (IOP). Ophthalmological examination, ultrasound, and ultrasound biomicroscopy were performed; congenital infections were ruled out. Genetic analysis was performed. The patient underwent penetrating keratoplasty and goniotomy in a single surgical time...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28644235/chandelier-illumination-for-descemet-membrane-endothelial-keratoplasty
#7
Toshiki Shimizu, Takahiko Hayashi, Kentaro Yuda, Ayako Tsuchiya, Itaru Oyakawa, Nobuhisa Mizuki, Naoko Kato
PURPOSE: To describe a simple technique that uses posterior chandelier illumination during Descemet membrane endothelial keratoplasty in cases of severe bullous keratopathy (BK). METHODS: Five eyes of 4 patients with advanced BK undergoing Descemet membrane endothelial keratoplasty were retrospectively analyzed. The pupil of the host eye was not treated with mydriatic or miotic agents. The chandelier illuminator was inserted transconjunctivally into the vitreous cavity from the pars plana...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28644234/efficacy-of-sodium-hyaluronate-in-murine-diabetic-ocular-surface-diseases
#8
Guohu Di, Xia Qi, Xiaowen Zhao, Songmei Zhang, Qingjun Zhou
PURPOSE: To evaluate the efficacy of sodium hyaluronate (HA) eye drops for the treatment of diabetic ocular surface diseases in mice. METHODS: Male 6- to 8-week-old C57BL/6 mice underwent induction of type 1 diabetes with intraperitoneal injections of streptozotocin, with normal mice as the control. Topical 0.3% HA, 0.1% HA, 0.4% polyethylene glycol eye drops, and normal saline were administered to diabetic mice with an intact or debrided corneal epithelium. Normal saline was applied in the controls...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28644233/tyrosine-kinase-inhibitor-vatalanib-inhibits-proliferation-and-migration-of-human-pterygial-fibroblasts
#9
Hong Kyu Kim, Ji-Young Choi, Sang Min Park, Chang Rae Rho, Kyong Jin Cho, Sangmee Ahn Jo
PURPOSE: Vatalanib is a small-molecule tyrosine kinase inhibitor. We investigated the effects of vatalanib on the proliferation and migration of cultured human pterygial fibroblasts (HPFs). METHODS: Pterygium tissues were obtained after pterygium excision surgery and subjected to primary culture. HPFs were treated with vatalanib at various concentrations. Mitomycin C (MMC) was used as a positive control. Cell proliferation and migration assays were used to investigate the effects of vatalanib...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28644232/case-of-presumed-transient-light-sensitivity-syndrome-after-small-incision-lenticule-extraction
#10
Jordan D Desautels, Majid Moshirfar, Tyler S Quist, David F Skanchy, Phillip C Hoopes
PURPOSE: To report the first presumed case of transient light-sensitivity syndrome (TLSS) after small-incision lenticule extraction (SMILE). METHODS: A 27-year-old male patient was treated for severe photophobic symptoms occurring 7 weeks after undergoing a bilateral SMILE procedure. His comprehensive ocular examination was unremarkable and his visual acuity was unaffected. Treatment was a month-long tapering dose of topical steroids. RESULTS: Photophobic symptoms fully resolved after steroid treatment...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28628505/central-connections-of-the-lacrimal-functional-unit
#11
Catherine Willshire, Roger J Buckley, Anthony J Bron
PURPOSE: To study the contribution of each eye to the reflex tear response, after unilateral and bilateral topical anesthesia. METHOD: A closed-eye, modified Schirmer test was performed bilaterally in 8 normal subjects, in a controlled environment chamber set to 23°C, 45% relative humidity, and 0.08 m/s airflow. Eye drops were instilled into each eye 10 minutes before the Schirmer test. Experiments were as follows: 1) bilateral saline (control), 2) unilateral anesthesia (ipsilateral anesthetic; contralateral saline), and 3) bilateral anesthesia...
June 14, 2017: Cornea
https://www.readbyqxmd.com/read/28628504/morphology-and-function-of-meibomian-glands-and-other-tear-film-parameters-in-junior-high-school-students
#12
Takanori Mizoguchi, Reiko Arita, Shima Fukuoka, Naoyuki Morishige
PURPOSE: We measured tear film parameters, including the morphology and function of meibomian glands, in junior high school students at 15 years of age. METHODS: A total of 111 eyes of 111 students (56 males and 55 females) were enrolled in the study. The ocular symptom score (0-14), after-school study time, lipid layer thickness (LLT) of the tear film, partial blink rate, lid margin abnormalities (0-4), tear film breakup time, corneal and conjunctival epithelial damage (fluorescein staining score, 0-9), meiboscore as determined by noncontact meibography (0-6), Schirmer test value, and meibum grade (0-3) were determined...
June 14, 2017: Cornea
https://www.readbyqxmd.com/read/28628503/influence-of-refractive-status-on-the-higher-order-aberration-pattern-after-small-incision-lenticule-extraction-surgery
#13
Liuyang Li, George P M Cheng, Alex L K Ng, Tommy C Y Chan, Vishal Jhanji, Yan Wang
PURPOSE: To study the effect of myopia on the pattern change in higher-order aberrations after small incision lenticule extraction. METHODS: Sixty eyes of 60 patients were included: low myopia (≤-3.00 D), moderate myopia (-3.00 D to -6.00 D), and high myopia (≥-6.00 D). Total higher-order aberrations (tHOA), vertical coma (C3), horizontal coma (C3), and spherical aberration (C4) were measured preoperatively and at postoperative 3 months. RESULTS: At the end of 3 months, tHOA changed significantly compared with the preoperative values (P < 0...
June 14, 2017: Cornea
https://www.readbyqxmd.com/read/28614157/probable-donor-derived-cytomegalovirus-disease-after-keratolimbal-allograft-transplantation
#14
Albert Y Cheung, Amit Govil, Scott R Friedstrom, Edward J Holland
PURPOSE: To report a case of probable donor-derived cytomegalovirus (CMV) infection after keratolimbal allograft (KLAL) transplantation. METHODS: Observational case report. RESULTS: A 41-year-old man with a history of aniridic keratopathy and limbal stem cell deficiency underwent KLAL in his right eye. Preoperatively, he was negative for CMV IgG and IgM. Postoperatively, he was maintained on tacrolimus and mycophenolate mofetil for systemic immunosuppression; he was also on prophylactic valganciclovir (for CMV) and trimethoprim/sulfamethoxazole (for pneumocystis pneumonia) for 1 month...
June 13, 2017: Cornea
https://www.readbyqxmd.com/read/28614156/endothelial-cell-loss-in-diabetic-and-nondiabetic-eyes-after-cataract-surgery
#15
Xu He, Vasilios F Diakonis, Yasamin Alavi, Nilufer Yesilirmak, Daniel Waren, Kendall Donaldson
PURPOSE: To assess and compare the changes in endothelial cell density in diabetic and nondiabetic patients after routine phacoemulsification cataract surgery. SETTING: Bascom Palmer Eye Institute, Miller School of Medicine, Miami, FL, USA. DESIGN: Retrospective nonrandomized cohort study. METHODS: This retrospective study included diabetic and nondiabetic patients who underwent phacoemulsification by a single surgeon (K...
June 13, 2017: Cornea
https://www.readbyqxmd.com/read/28614155/the-role-of-the-back-plate-in-angle-anatomy-with-the-boston-type-i-keratoprosthesis
#16
Elise V Taniguchi, Eleftherios I Paschalis, Alja Crnej, Ai Ren, Kathryn A Colby, James Chodosh, Louis R Pasquale, Lucy Q Shen, Claes H Dohlman, Andrea Cruzat
PURPOSE: To quantitatively evaluate the angle anatomy in eyes with the Boston type I keratoprosthesis (B-KPro) differing in the back plate (BP) material and size using anterior segment optical coherence tomography. METHODS: B-KPro eyes with poly(methyl methacrylate) (PMMA) (7.0 and 8.5 mm) and titanium (7.0, 8.5, and 9.5 mm) BPs were imaged with anterior segment optical coherence tomography. The angle opening distance at 500 μm from the scleral spur (AOD500), trabecular iris surface area at 500 μm from the scleral spur (TISA500), and trabecular iris angle at 500 μm from the scleral spur (TIA500) were measured...
June 13, 2017: Cornea
https://www.readbyqxmd.com/read/28614154/regression-of-inflamed-pterygia-by-frequent-high-dose-intralesional-ziv-aflibercept
#17
Ahmad M Mansour
PURPOSE: Intralesional single low-dose vascular endothelial growth factor antagonists have traditionally failed in causing regression of pterygia. The current pilot study investigates the role of high-dose repeated intralesional ziv-aflibercept in causing regression of inflamed or recurring pterygia. METHODS: This prospective study from January 2015 to April 2017 consisted of using high dose of ziv-aflibercept between 0.1 mL (2.5 mg) and 0.3 mL (7.5 mg), depending on the pterygium size and the degree of inflammation...
June 13, 2017: Cornea
https://www.readbyqxmd.com/read/28614153/further-analysis-of-the-predictability-of-corneal-endothelial-cell-density-estimates-when-polymegethism-is-present
#18
Michael J Doughty
PURPOSE: To assess variability in endothelial cell density (ECD) estimates when polymegethism (variance in cell areas) is present. METHODS: Using noncontact specular microscope images of the corneal endothelium, 4 sets of 20 cases were selected, which included 200 cells and had coefficient of variation values of less than 30% (group 1), 31%-40% (group 2), 41%-50% (group 3), and over 50% (group 4). A stepwise analysis was undertaken, 20 cells at a time, of the ECD estimates when using different numbers of cells for the calculations...
June 13, 2017: Cornea
https://www.readbyqxmd.com/read/28614152/superficial-automated-keratopigmentation-for-iris-and-pupil-simulation-using-micronized-mineral-pigments-and-a-new-puncturing-device-experimental-study
#19
Alejandra E Rodriguez, Maria A Amesty, Mohammed El Bahrawy, Severino Rey, Jorge Alio Del Barrio, Jorge L Alio
PURPOSE: To study the outcomes and tolerance of micronized mineral pigments for corneal tattooing, using a superficial automated keratopigmentation (SAK) technique in an experimental animal model and a new puncture device to inject the pigments into the corneal stroma. METHODS: Forty eyes of 40 New Zealand rabbits were included in this study. The animals were divided into groups A and B. Both groups underwent SAK using a new automated keratopigmentation device. Micronized mineral pigments were injected through the epithelium into the corneal stroma to replicate the iris color in 25 eyes (group A), and black color was used to replicate the pupil in 15 eyes (group B)...
June 13, 2017: Cornea
https://www.readbyqxmd.com/read/28590267/reply
#20
Zhang Xinxin, Richard M Davis
No abstract text is available yet for this article.
June 2, 2017: Cornea
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