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Cornea

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https://www.readbyqxmd.com/read/28306602/cure-rate-of-fungal-keratitis-with-antibacterial-therapy
#1
Alice Y Matoba, Ryan Barrett, Anna E Lehmann
PURPOSE: To study the cure rate of fungal keratitis with moxifloxacin 0.3% monotherapy. METHODS: A retrospective review of patients with culture-proven fungal keratitis who initially received moxifloxacin 0.3% monotherapy was performed. RESULTS: Eleven patients with culture-proven fungal keratitis were initially treated with moxifloxacin. One case each of Curvularia and Alternaria keratitis resolved with moxifloxacin monotherapy (18%). CONCLUSIONS: Moxifloxacin may have a significant clinical therapeutic effect in a subset of patients with fungal keratitis...
March 16, 2017: Cornea
https://www.readbyqxmd.com/read/28306601/assessing-the-impact-of-diabetes-mellitus-on-donor-corneal-endothelial-cell-density
#2
Chase A Liaboe, Benjamin T Aldrich, Pamela C Carter, Jessica M Skeie, Kimberlee A Burckart, Gregory A Schmidt, Cynthia R Reed, M Bridget Zimmerman, Mark A Greiner
PURPOSE: To quantify changes in endothelial cell density (ECD) of donor corneal tissue in relation to the presence or absence of a medical history of diabetes mellitus diagnosis, treatment, and complications. METHODS: A retrospective review was performed for all corneas collected at Iowa Lions Eye Bank between January 2012 and December 2015. For purposes of analysis, donor corneas were divided into 4 groups: nondiabetic, non-insulin-dependent diabetic, insulin-dependent diabetic without medical complications due to diabetes, and insulin-dependent diabetic with medical complications due to diabetes...
March 16, 2017: Cornea
https://www.readbyqxmd.com/read/28306600/modeling-endothelial-cell-loss-after-descemet-stripping-endothelial-keratoplasty-data-from-5-years-of-follow-up
#3
Mark A P Fajgenbaum, Emma J Hollick
PURPOSE: To report 5-year outcomes for graft survival and endothelial cell survival after Descemet stripping endothelial keratoplasty (DSEK) including regression modeling for cell survival over time. METHODS: This is a single-institution, retrospective, consecutive interventional series of 210 primary DSEK grafts operated for low-to-moderate risk indications, specifically Fuchs dystrophy and bullous keratopathy. Primary outcomes were cumulative graft survival and % endothelial cell loss from 3 months through 5 years; the secondary outcome was to trend endothelial cell density over time by least-squares and mixed nonlinear modeling...
March 16, 2017: Cornea
https://www.readbyqxmd.com/read/28306599/knowledge-and-attitude-toward-corneal-donation-among-high-school-children-in-northern-india
#4
Parul Chawla Gupta, Mona Duggal, Limalemla Jamir, Drishti Sharma, Ankita Kankaria, Shreyaswi Sathyanath, Rupinder Kaur, Kirtan Rana, Jagat Ram
PURPOSE: To assess the knowledge and attitude of school-going adolescents regarding corneal donation in government and private schools in an urban area of Northern India. METHODS: A school-based cross-sectional study was conducted in an urban field practice area of Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. A total of 365 participants of the seventh to 10th grade were enrolled from a government school and a private school...
March 16, 2017: Cornea
https://www.readbyqxmd.com/read/28306598/comparing-the-effects-of-particulate-matter-on-the-ocular-surfaces-of-normal-eyes-and-a-dry-eye-rat-model
#5
Ji Yun Han, Boram Kang, Youngsub Eom, Hyo Myung Kim, Jong Suk Song
PURPOSE: To compare the effect of exposure to particulate matter on the ocular surface of normal and experimental dry eye (EDE) rat models. METHODS: Titanium dioxide (TiO2) nanoparticles were used as the particulate matter. Rats were divided into 4 groups: normal control group, TiO2 challenge group of the normal model, EDE control group, and TiO2 challenge group of the EDE model. After 24 hours, corneal clarity was compared and tear samples were collected for quantification of lactate dehydrogenase, MUC5AC, and tumor necrosis factor-α concentrations...
March 16, 2017: Cornea
https://www.readbyqxmd.com/read/28257387/repeat-keratoplasty-for-failed-deep-anterior-lamellar-keratoplasty-in-keratoconus-incidence-indications-and-outcomes
#6
Sepehr Feizi, Mohammad Ali Javadi, Pejman Khajuee-Kermani, Roya Jafari
PURPOSE: To analyze the incidence, indications, and clinical outcomes of penetrating keratoplasty (PK) and repeat deep anterior lamellar keratoplasty (DALK) after failed DALK for keratoconus. METHODS: This retrospective interventional case series reviewed the medical records of patients with keratoconus who underwent DALK and were followed up for at least 1 year. Patients who underwent PK or repeat DALK for failed DALK were identified. The incidence, indications, and clinical outcomes after repeat keratoplasty were assessed...
March 1, 2017: Cornea
https://www.readbyqxmd.com/read/28257386/rapid-warming-of-donor-corneas-is-safe-and-improves-specular-image-quality
#7
Khoa D Tran, Jameson Clover, Amy Ansin, Christopher G Stoeger, Mark A Terry
PURPOSE: To determine whether warming donor corneas to near-physiological temperatures can safely shorten warming times while providing high-quality specular images during tissue evaluation. METHODS: Mated corneas were warmed at room temperature (RT) or at 35°C for 4 hours upon removal from cold storage. Specular images and endothelial cell densities were acquired and rated every hour. Additional mated corneas were subjected to 2 rounds of 4-hour incubation at either RT or 35°C...
March 1, 2017: Cornea
https://www.readbyqxmd.com/read/28257385/in-vitro-evaluation-of-the-drug-reservoir-function-of-human-amniotic-membrane-using-moxifloxacin-as-a-model-drug
#8
Madhavi Latha Yelchuri, Bhagyashree Madhavi, Nilam Gohil, Hitha Sara Sajeev, Namperumalsamy Venkatesh Prajna, Senthilkumari Srinivasan
PURPOSE: To evaluate the in vitro, extended drug reservoir function of human amniotic membrane (HAM) of different thicknesses impregnated with moxifloxacin. METHODS: HAM buttons (12 mm) were soaked with freshly prepared 0.5% wt/vol topical moxifloxacin at different soaking time intervals: 3 hours (group I), 6 hours (group II), 12 hours (group III), 24 hours (group IV), and 48 hours (group V). They were then transferred into 1 mL of fresh simulated tear fluid (pH-7...
March 1, 2017: Cornea
https://www.readbyqxmd.com/read/28257384/meibomian-gland-dysfunction-in-patients-with-chemotherapy-induced-lacrimal-drainage-obstruction
#9
Youngsub Eom, Sehyun Baek, Hyo Myung Kim, Jong Suk Song
PURPOSE: To investigate the relationship between chemotherapy-induced lacrimal drainage (LD) obstruction and obstructive meibomian gland dysfunction. METHODS: Twenty patients who had received chemotherapy were divided into 2 groups, according to the presence of LD obstruction: the LD obstruction group (n = 10) and control group (n = 10). Upper and lower meibomian gland loss was evaluated using noncontact meibography, and tear film lipid layer thickness was measured using an interferometer...
March 1, 2017: Cornea
https://www.readbyqxmd.com/read/28257383/conjunctival-tattoo-with-inadvertent-globe-penetration-and-associated-complications
#10
Natasha Ferreira Santos da Cruz, Kátia Santana Santos, Michelle de Lima Farah, Sergio Felberg
PURPOSE: To report a case of conjunctival tattooing for cosmetic purposes with inadvertent globe penetration resulting in severe inflammation, capsular lens opacity, and secondary glaucoma. METHODS: Case report. RESULTS: A 25-year-old woman experienced severe ocular pain and decreased vision in the left eye after conjunctival tattooing for cosmetic purposes on the previous day. Slit-lamp examination revealed black deposits over the conjunctiva, corneal endothelium, anterior chamber angle, iris, and anterior capsular lens due to the tattooing pigment...
March 1, 2017: Cornea
https://www.readbyqxmd.com/read/28257382/customized-corneal-cross-linking-a-mathematical-model
#11
Ciro Caruso, Robert L Epstein, Carmine Ostacolo, Luigi Pacente, Salvatore Troisi, Gaetano Barbaro
PURPOSE: To improve the safety, reproducibility, and depth of effect of corneal cross-linking with the ultraviolet A (UV-A) exposure time and fluence customized according to the corneal thickness. METHODS: Twelve human corneas were used for the experimental protocol. They were soaked using a transepithelial (EPI-ON) technique using riboflavin with the permeation enhancer vitamin E-tocopheryl polyethylene glycol succinate. The corneas were then placed on microscope slides and irradiated at 3 mW/cm for 30 minutes...
March 1, 2017: Cornea
https://www.readbyqxmd.com/read/28257381/effect-of-sleep-position-on-the-ocular-surface
#12
David Alevi, Henry D Perry, Alexander Wedel, Eric Rosenberg, Limor Alevi, Eric D Donnenfeld
PURPOSE: Dry eye disease is a multifactorial disease with numerous well-documented risk factors. However, to date, sleep position has not been associated with this condition. After observing patients in our practice, we believe that the sleep position in some cases may significantly affect dry eye and meibomian gland dysfunction (MGD). METHODS: This is a single-centered, cross-sectional, noninterventional, institutional review board-approved, single-masked, nonrandomized study of 100 patients whose complaints were related to dry eye disease and a control group of 25 age-matched asymptomatic patients...
March 1, 2017: Cornea
https://www.readbyqxmd.com/read/28257380/corneal-transplantation-in-auckland-new-zealand-1999-2009-indications-patient-characteristics-ethnicity-social-deprivation-and-access-to-services
#13
Alexandra Z Crawford, James McKelvie, Jennifer P Craig, Charles N J McGhee, Dipika V Patel
PURPOSE: To analyze characteristics and indications for corneal transplantation in patients undergoing penetrating, lamellar, and endothelial keratoplasty in Auckland, New Zealand (NZ). METHODS: Corneal transplantation data from the NZ National Eye Bank and hospital records of corneal transplant recipients in the Auckland region from January 1, 2000, to December 31, 2009, were collated. Patient demographics, preoperative diagnosis, indication, ocular and medical history, visual acuity, deprivation index, and access to transplantation surgery were analyzed...
March 1, 2017: Cornea
https://www.readbyqxmd.com/read/28257379/use-of-crossed-polarizers-to-enhance-images-of-the-eyelids
#14
Ryan OʼSullivan, Lisa M Tom, Vatinee Y Bunya, William C Nyberg, Mina Massaro-Giordano, Ebenezer Daniel, Eli Smith, David H Brainard, James Gee, Maureen G Maguire, Richard A Stone
PURPOSE: To describe imaging of the external eye with Crossed Polarizers to enhance clinically important features in digital photographs of the eyelids. METHODS: External photographs with and without crossed polarizing filters were taken of patients with blepharitis and controls with no clinical eye pathology. RESULTS: Photographing eyelid skin through Crossed Polarizers decreased reflections on the skin surface and improved visualization of eyelid telangiectasias and blood vessels in patients with a broad range of skin pigmentation and ethnicities...
March 1, 2017: Cornea
https://www.readbyqxmd.com/read/28230557/comparison-of-the-conventional-dresden-protocol-and-accelerated-protocol-with-higher-ultraviolet-intensity-in-corneal-collagen-cross-linking-for-keratoconus
#15
Moonjung Choi, Jiwon Kim, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To compare the accelerated corneal cross-linking (CXL) protocol and the conventional Dresden protocol in patients with keratoconus in terms of visual acuity, keratometric values, and topographic parameters. METHODS: Twenty-eight eyes of 25 patients with primary keratoconus were divided into 2 groups; 15 eyes in group 1 received CXL under the standard Dresden protocol (3 mW/cm for 30 min, dose 5.4 J/cm) and 13 eyes in group 2 were treated with the accelerated protocol (30 mW/cm for 3 min 40 s, dose 6...
February 22, 2017: Cornea
https://www.readbyqxmd.com/read/28207433/long-term-clinical-course-in-eyes-with-peters-anomaly
#16
Haruna Yoshikawa, Chie Sotozono, Yoko Ikeda, Kazuhiko Mori, Morio Ueno, Shigeru Kinoshita
PURPOSE: Peters anomaly (PA) is known to be a primary cause of congenital corneal opacity. The aim of this study is to report the long-term clinical course and visual achievement of patients with PA who did not undergo keratoplasty. METHODS: This retrospective study involved 15 eyes of 9 infants with PA less than 5 months of age at initial presentation at the Kyoto Prefectural University of Medicine who were followed up without keratoplasty for more than 6 years after presentation...
February 15, 2017: Cornea
https://www.readbyqxmd.com/read/28207432/spontaneous-canalicular-plug-erosion-after-punctal-plug-placement
#17
Xinxin Zhang, Maya Bitar, Richard M Davis
PURPOSE: To describe a case of keratoconjunctivitis sicca treated with punctal plug placement with the first reported complication of subsequent plug erosion through the canaliculus and extrusion through the lid. METHODS: Punctal plugs were placed in a patient with Sjogren syndrome for treatment of keratoconjunctivitis sicca. More than 12 years later, the plug was noted to have eroded through the canaliculus and extruded through the conjunctiva and lid. RESULTS: The extruded plug was removed, and punctal cautery was performed on 2 other puncta with improved symptom control...
February 15, 2017: Cornea
https://www.readbyqxmd.com/read/28207431/successful-medical-management-of-presumptive-pythium-insidiosum-keratitis
#18
Muralidhar Ramappa, Ritu Nagpal, Savitri Sharma, Sunita Chaurasia
PURPOSE: To describe the previously unreported successful treatment of presumptive Pythium keratitis (PK) with medical therapy alone. METHODS: A 42-year-old female homemaker presented to us with a 15-day history of pain and redness in the right eye after a trivial injury. Her vision was 20/80 at presentation. Slit-lamp biomicroscopy revealed a central, dense and dry-looking, grayish-white infiltrate reaching mid stroma. The infiltrate had feathery margins and was surrounded by multiple tentacle-like lesions and peripherally expanding pinhead-sized subepithelial lesions...
February 15, 2017: Cornea
https://www.readbyqxmd.com/read/28181931/avoiding-complications-associated-with-preloaded-ultrathin-descemet-stripping-automated-endothelial-keratoplasty
#19
Mohit Parekh, Alessandro Ruzza, Bernhard Steger, Colin E Willoughby, Stefano Ferrari, Diego Ponzin, Stephen B Kaye, Vito Romano
No abstract text is available yet for this article.
February 8, 2017: Cornea
https://www.readbyqxmd.com/read/28181930/recurrent-conjunctival-myofibrosarcoma-managed-with-triple-application-of-episcleral-brachytherapy
#20
Sean M Platt, Lynn Schoenfield, Surendra Basti, Paul J Bryar, John R Goldblum, Annapurna Singh, Arun D Singh
PURPOSE: To report a case of recurrent conjunctival myofibrosarcoma treated with wide surgical excision, cryotherapy, and triple sequential applications of episcleral brachytherapy. METHODS: A single case of recurrent conjunctival myofibrosarcoma. RESULTS: A 54-year-old man with a history of a renal transplant presented with a recurrent conjunctival tumor. Histopathologic diagnosis was established through immunohistochemistry. In total, 3 iodine radiation episcleral plaques were used over a period of 49 weeks...
February 8, 2017: Cornea
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