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Cornea

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https://www.readbyqxmd.com/read/30394912/ocular-and-genetic-characteristics-observed-in-two-cases-of-fish-eye-disease
#1
Melih Ustaoglu, Nilgun Solmaz, Burak Baser, Hande Kucuk Kurtulgan, Feyza Onder
PURPOSE: To present ocular findings and anterior segment-optical coherence tomography (AS-OCT) imaging findings of 2 cases of fish-eye disease (FED) involving 2 novel genetic variants of the lecithin-cholesterol acyltransferase (LCAT) gene. METHODS: A case report. RESULTS: A 46-year-old woman and 63-year-old man presented with blurred vision, burning sensation, and whitening of both eyes for 2 and 3 years, respectively. Ophthalmologic examination revealed slightly decreased visual acuity, yellowish-white diffuse corneal opacities causing corneal clouding, and dry eye disease bilaterally in both patients...
November 2, 2018: Cornea
https://www.readbyqxmd.com/read/30379722/ocular-toxicity-of-mirvetuximab
#2
Eleonora Corbelli, Elisabetta Miserocchi, Alessandro Marchese, Chiara Giuffrè, Luigi Berchicci, Riccardo Sacconi, Francesco Bandello, Giulio Maria Modorati
PURPOSE: To report the clinical features and outcomes of corneal toxicity following mirvetuximab soravtansine therapy. METHODS: Five patients who were treated with mirvetuximab soravtansine were evaluated in our hospital for ocular symptoms during a period of 5 months between December 2017 and April 2018. A complete ophthalmologic examination, including anterior segment infrared reflectance (AS-IR) and anterior segment optical coherence tomography (AS-OCT), was performed...
October 30, 2018: Cornea
https://www.readbyqxmd.com/read/30379721/tear-meniscus-and-corneal-sub-basal-nerve-plexus-assessment-in-primary-sj%C3%A3-gren-syndrome-and-sicca-syndrome-patients
#3
Joana Cardigos, Filipe Barcelos, Helena Carvalho, Diogo Hipólito, Sara Crisóstomo, José Vaz-Patto, Nuno Alves
PURPOSE: To evaluate lower tear meniscus and corneal sub-basal nerve plexus in primary Sjögren's syndrome (pSS) and Sicca syndrome patients. METHODS: Cross-sectional study of 116 patients with Sicca syndrome associated with pSS and not associated with Sjögren's syndrome (non-SS Sicca) and 20 normal control subjects. Tear meniscus height and area were measured using anterior segment optical coherence tomography; corneal sub-basal nerve plexus density, length, and tortuosity were evaluated using in vivo confocal microscopy...
October 30, 2018: Cornea
https://www.readbyqxmd.com/read/30379720/response-to-central-corneal-thickness-evaluation-in-diabetic-peripheral-neuropathy
#4
Maddalena De Bernardo, Ilaria De Pascale
No abstract text is available yet for this article.
October 30, 2018: Cornea
https://www.readbyqxmd.com/read/30379719/evaluation-of-the-repeatability-and-reproducibility-of-corneal-epithelial-thickness-mapping-for-a-9-mm-zone-using-optical-coherence-tomography
#5
Jack X Ma, Li Wang, Mitchell P Weikert, Ildamaris Montes de Oca, Douglas D Koch
PURPOSE: To evaluate the repeatability and between-machine/operator reproducibility of optical coherence tomography (RTVue-XR) for mapping corneal epithelial thickness (ET) and corneal thickness (CT) over a 9-mm zone. METHODS: In 5 groups of eyes (normal, contact lens, dry eye, post-LASIK/PRK, and keratoconus), corneal ET and CT were evaluated in 25 areas in the following 4 regions: 1) 1 central zone within 0 to 2.0 mm diameter, 2) 8 paracentral zones from 2.0 to 5...
October 30, 2018: Cornea
https://www.readbyqxmd.com/read/30379718/topical-ganciclovir-for-prophylaxis-of-cytomegalovirus-endotheliitis-in-endothelial-keratoplasty
#6
Alfred Basilious, Hall F Chew
PURPOSE: To describe the presentation and management of 2 cases of Descemet stripping automated endothelial keratoplasty (DSAEK) with failure secondary to cytomegalovirus (CMV) infection and prophylaxis with topical ganciclovir to prevent repeat failure of Descemet membrane endothelial keratoplasty (DMEK) regrafts. METHODS: A retrospective chart review was conducted for 2 patients with DSAEK failure secondary to CMV infection. RESULTS: A 70-year-old immunocompetent man (case 1) and a 53-year-old immunocompromised man (case 2) received DSAEK for presumed pseudophakic bullous keratopathy and endothelial decompensation secondary to recurrent uveitis, respectively...
October 30, 2018: Cornea
https://www.readbyqxmd.com/read/30371566/vault-changes-caused-by-light-induced-pupil-constriction-and-accommodation-in-eyes-with-an-implantable-collamer-lens
#7
Sayaka Kato, Kimiya Shimizu, Akihito Igarashi
PURPOSE: An appropriate vault after implantation of a posterior chamber phakic intraocular lens with a central hole (ICL KS-AP) is important for successful long-term outcomes. In the present study, we used anterior segment optical coherence tomography (AS-OCT) to examine dynamic pupil and vault changes under photopic and scotopic conditions and during accommodation in eyes with ICL KS-AP. METHODS: This retrospective study included patients at an outpatient ophthalmology clinic who underwent ICL KS-AP implantation >1 month before enrollment...
October 26, 2018: Cornea
https://www.readbyqxmd.com/read/30365412/randomized-study-of-collagen-cross-linking-with-conventional-versus-accelerated-uva-irradiation-using-riboflavin-with-hydroxypropyl-methylcellulose-two-year-results
#8
Anne Marie Hagem, Andreas Thorsrud, Gunhild Falleth Sandvik, Liv Drolsum
PURPOSE: To compare the clinical outcome 2 years after corneal collagen cross-linking (CXL) with conventional and accelerated ultraviolet A (UVA) irradiation using riboflavin with hydroxypropyl methylcellulose. METHODS: Prospective randomized controlled study. Forty patients with keratoconus (40 eyes) were randomized to either CXL using conventional 3 mW/cm UVA irradiation for 30 minutes (CXL30 group) or accelerated 9 mW/cm UVA irradiation for 10 minutes (CXL10 group)...
October 24, 2018: Cornea
https://www.readbyqxmd.com/read/30365411/high-dose-steroid-treatment-of-bacterial-keratitis
#9
Matthew Green, Ian Hughes, John Hogden, Sergio Sara, Andrew Apel, Fiona Stapleton
PURPOSE: To describe the usage patterns of steroids in bacterial keratitis and to analyze the effect of steroids on patients' visual outcomes. METHODS: This was a single-center retrospective review of patients with culture-positive bacterial keratitis treated between 1999 and 2015 at Princess Alexandra Hospital (Brisbane, Australia). Patients with culture-positive bacterial keratitis were identified through the Queensland Pathology Database, and clinical information was gathered through a subsequent medical record review...
October 24, 2018: Cornea
https://www.readbyqxmd.com/read/30371569/classification-of-limbal-stem-cell-deficiency-using-clinical-and-confocal-grading
#10
Carolina Aravena, Kansu Bozkurt, Pichaya Chuephanich, Chantaka Supiyaphun, Fei Yu, Sophie X Deng
PURPOSE: To grade the severity of limbal stem cell deficiency (LSCD) based on the extent of clinical presentation and central corneal basal epithelial cell density (BCD). METHODS: This is a retrospective observational comparative study of 48 eyes of 35 patients with LSCD and 9 eyes of 7 normal subjects (controls). Confocal images of the central cornea were acquired. A clinical scoring system was created based on the extent of limbal and corneal surface involvement...
October 23, 2018: Cornea
https://www.readbyqxmd.com/read/30371568/evaluation-of-autologous-blood-in-pterygium-surgery-with-conjunctival-autograft
#11
Weijuan Zeng, Hanjun Dai, Hong Luo
PURPOSE: Autologous blood has been used exploratively with conjunctival autograft in pterygium surgery. However, it is controversial whether autologous blood performed better than other fixation methods, including fibrin glue and sutures. This meta-analysis was conducted to evaluate the effectiveness of using autologous blood in pterygium surgery with conjunctival autograft. METHODS: The study was conducted according to the PRISMA guidelines. The MEDLINE, Cochrane library, and Embase databases were systematically searched from their establishment until April 1, 2018...
October 23, 2018: Cornea
https://www.readbyqxmd.com/read/30371567/ocular-surface-stem-cell-transplantation-for-treatment-of-keratitis-ichthyosis-deafness-syndrome
#12
Albert Y Cheung, Sunny Patel, Khaliq H Kurji, Enrica Sarnicola, Medi Eslani, Amit Govil, Edward J Holland
PURPOSE: To report our surgical experience with ocular surface stem cell transplantation (OSST) for limbal stem cell deficiency (LSCD) in the setting of keratitis-ichthyosis-deafness (KID) syndrome. METHODS: Retrospective interventional case series. RESULTS: We present 5 eyes of 3 patients with KID syndrome that developed LSCD and underwent OSST. Mean follow-up after OSST was 8.3 ± 4.3 years (range 3.4-11.4 years). Two eyes underwent living-related conjunctival limbal allograft (lr-CLAL), and 3 eyes were treated with keratolimbal allograft (KLAL)...
October 23, 2018: Cornea
https://www.readbyqxmd.com/read/30346345/preloaded-descemet-membrane-endothelial-keratoplasty-donor-tissue-surgical-technique-and-early-clinical-results
#13
Pranita Sahay, Deepali Singhal, Prafulla K Maharana, Jeewan S Titiyal
No abstract text is available yet for this article.
October 19, 2018: Cornea
https://www.readbyqxmd.com/read/30346344/retrospective-single-center-registry-study-on-graft-thickness-1-year-after-descemet-stripping-automated-endothelial-keratoplasty
#14
Andreas Gormsen, Anders Ivarsen, Jesper Hjortdal
PURPOSE: To compare the graft thickness of eye bank precut grafts with graft thickness measured 1 year after Descemet stripping automated endothelial keratoplasty (DSAEK) and to correlate the graft thickness of eye bank precut grafts with best spectacle-corrected visual acuity (BSCVA) and endothelial cell density (ECD) 1 year after DSAEK. METHODS: This was a retrospective registry study of 183 eyes of 179 DSAEK patients. Grafts were cut in the eye bank after 1 day in dextran-containing medium, and thickness was measured by optical coherence tomography immediately after precutting...
October 19, 2018: Cornea
https://www.readbyqxmd.com/read/30346343/influence-of-intraoperative-air-tamponade-time-on-graft-adherence-in-descemet-membrane-endothelial-keratoplasty
#15
Diana Santander-García, Jorge Peraza-Nieves, Thomas M Müller, Nadine Gerber-Hollbach, Lamis Baydoun, Vasilios S Liarakos, Isabel Dapena, Silke Oellerich, Korine Van Dijk, Gerrit R J Melles
PURPOSE: To study the influence of different intraoperative air tamponade times on graft adherence after Descemet membrane endothelial keratoplasty (DMEK). METHODS: In this interventional case series, we evaluated 117 eyes with Fuchs endothelial corneal dystrophy (FECD) that underwent DMEK using intraoperative air tamponade times of 60 minutes (group I; n = 39), 45 minutes (group II; n = 39), or 30 minutes (group III; n = 39). At 1 and 6 months postoperatively, graft adherence status, endothelial cell density, central pachymetry, and postoperative complications were recorded...
October 19, 2018: Cornea
https://www.readbyqxmd.com/read/30346342/postoperative-repositioning-of-inverted-descemet-membrane-endothelial-keratoplasty-grafts
#16
Diana C Dragnea, Siamak Nobacht, Adrian Gericke, Jack Parker, Silke Oellerich, Lisanne Ham, Gerrit R J Melles
PURPOSE: To present 4 cases of postoperative repositioning of inverted grafts after Descemet membrane endothelial keratoplasty (DMEK). METHODS: Retrospective case reports of 4 patients presenting with subtotal to total graft detachment after DMEK, most probably owing to upside-down graft positioning. Graft repositioning was performed 1 to 14 days after initial DMEK surgery. In 3 cases (cases 1, 3, and 4), repositioning was performed without removing the graft from the anterior chamber (AC), whereas for case 2, the graft had to be removed from the AC to attain correct graft orientation...
October 19, 2018: Cornea
https://www.readbyqxmd.com/read/30346341/capnocytophaga-keratitis-clinical-presentation-and-use-of-metagenomic-deep-sequencing-for-diagnosis
#17
Gerami D Seitzman, Praneetha Thulasi, Armin Hinterwirth, Cindi Chen, Jessica Shantha, Thuy Doan
PURPOSE: To report our experience with 2 cases of Capnocytophaga keratitis. METHODS: This is a retrospective study of case reports. We present the clinical presentation, diagnosis, and treatment strategies of 2 patients who presented with Capnocytophaga keratitis. RESULTS: Both patients had risk factors including systemic immune compromise and ocular trauma. Both patients had robust inflammatory keratitis with necrosis. Case 1 demonstrates identification of Capnocytophaga with traditional microbiologic techniques...
October 19, 2018: Cornea
https://www.readbyqxmd.com/read/30346340/use-of-a-purpose-built-impression-cytology-device-for-gene-expression-quantification-at-the-ocular-surface-using-quantitative-pcr-and-droplet-digital-pcr
#18
Kalaivarny Ganesalingam, Salim Ismail, Jennifer P Craig, Trevor Sherwin
PURPOSE: To describe an impression cytology (IC) technique using a purpose-built, sterile, EYEPRIM IC device that can be coupled with a TRIzol reagent-based RNA extraction protocol to yield sufficient RNA for gene expression analysis. METHODS: IC samples using the EYEPRIM device were collected from the bulbar conjunctiva, with and without topical anesthesia, and evaluated for RNA yield, the absence of polymerase chain reaction (PCR) inhibitors, and the ability to detect biomarkers by quantitative real-time PCR and droplet digital PCR...
October 19, 2018: Cornea
https://www.readbyqxmd.com/read/30334875/reply
#19
Lara R Newman, David L DeMill, Dorian A Zeidenweber, Zachary M Mayko, Alex J Bauer, Khoa D Tran, Mark A Terry
No abstract text is available yet for this article.
October 16, 2018: Cornea
https://www.readbyqxmd.com/read/30334874/descemet-membrane-endothelial-keratoplasty-dmek-graft-dislocation-into-the-vitreous-cavity
#20
Alfonso Vasquez-Perez, Nicholas Brennan, Tariq Ayoub, Bruce Allan, Daniel F P Larkin, Lyndon da Cruz
PURPOSE: To present our experience of Descemet stripping endothelial keratoplasty (DMEK) graft luxation into the vitreous cavity in 2 cases. METHODS: DMEK was performed in 2 patients with aphakic bullous keratopathy. The indications for keratoplasty were endothelial failure caused by chronic intermediate uveitis and glaucoma in 1 case and decompensated previous penetrating keratoplasty in the other. Both cases had enlarged pupils and had previously undergone pars plana vitrectomy...
October 16, 2018: Cornea
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