Andrew Sims, D Leann Long, Hemant K Tiwari, Jinhong Cui, Dustin M Long, Todd M Brown, Melissa J Smith, Emily B Levitan
Mediation analysis is an increasingly popular statistical method for explaining causal pathways to inform intervention. While methods have increased, there is still a dearth of robust mediation methods for count outcomes with excess zeroes. Current mediation methods addressing this issue are computationally intensive, biased, or challenging to interpret. To overcome these limitations, we propose a new mediation methodology for zero-inflated count outcomes using the marginalized zero-inflated Poisson (MZIP) model and the counterfactual approach to mediation...
April 18, 2024: Statistics in Medicine