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International Journal of Gynecological Pathology

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https://www.readbyqxmd.com/read/27801764/tissue-based-immunohistochemical-biomarker-accuracy-in-the-diagnosis-of-malignant-glandular-lesions-of-the-uterine-cervix-a-systematic-review-of-the-literature-and-meta-analysis
#1
Sandra Lee, Marianne S Rose, Vikrant V Sahasrabuddhe, Rachel Zhao, Máire A Duggan
Immunohistochemistry is widely used to support a pathology diagnosis of cervical adenocarcinoma despite the absence of a systematic review and meta-analysis of the published data. This systematic review and meta-analysis was performed to investigate the sensitivity and specificity of immunohistochemistry biomarkers in the tissue-based diagnosis of cervical adenocarcinoma histotypes compared with normal endocervix and benign glandular lesions. The systematic review and meta-analysis used a PICOT framework and QUADAS-2 to evaluate the quality of included studies...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27801763/unclassifiable-malignant-extraovarian-sex-cord-stromal-tumors-report-of-3-cases-and-review-of-extraovarian-sex-cord-stromal-tumors
#2
Rajeev Shah, W Glenn McCluggage
We report 3 cases of primary extraovarian unclassifiable malignant sex cord-stromal tumors. In all cases, the tumors involved the pelvis, peritoneum, and/or omentum and the morphologic features were essentially those of a poorly differentiated malignant neoplasm. A diagnosis of sex cord-stromal tumor was made on the basis of expression of several markers of ovarian sex cord-stromal tumors and exclusion of other neoplasms. In 1 case, an elevated serum testosterone was present at tumor progression. In reporting these cases, we draw attention to the problems in establishing a diagnosis that can be attributed to the extreme rarity of sex cord-stromal tumors in an extraovarian location and the rarity of unclassifiable malignant sex cord-stromal tumors in general, resulting in pathologists not considering this diagnosis...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27801762/value-of-pathology-review-in-a-population-based-series-of-ovarian-tumors
#3
Colin J R Stewart, Louise M Stewart, C D'Arcy J Holman, Susan Jordan, James Semmens, Katrina Spilsbury, Timothy Threlfall
Ovarian neoplasia comprises a heterogenous group of tumors with distinct clinicopathologic and molecular features and therefore assessment of potential risk factors should be tumor subtype specific. As part of ongoing epidemiological investigations of ovarian neoplasia in Western Australia, we performed an initial review of original pathology reports followed, in selected cases, by reassessment of histology material to optimize accurate diagnosis. Additional immunohistochemistry, often using antibodies unavailable at the time of initial assessment, was also performed as required...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27801761/endometrial-thickness-as-measured-by-transvaginal-ultrasound-and-the-corresponding-histopathologic-diagnosis-in-women-with-postmenopausal-bleeding
#4
Vatsal Patel, Edward J Wilkinson, Srikar Chamalan, Xiaomin Lu, Jacqueline Costagno, Demaretta Rush
Endometrial thickness as measured by transvaginal ultrasound (TVUS) is being increasingly used as a first-line method to evaluate patients with vaginal bleeding. Our study aims to examine correlation between the histopathologic diagnosis and the results of TVUS and find a threshold that could reliably exclude carcinoma. We included women, age 55 years and above, who presented with postmenopausal bleeding and had a TVUS within 30 days of their endometrial biopsy. Total of 304 patients met our criteria and were divided into 4 groups...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27801760/the-prevalence-of-lichen-sclerosus-in-patients-with-vulvar-squamous-cell-carcinoma
#5
Jonathan J Davick, Megan Samuelson, James T Krone, Colleen K Stockdale
Women with vulvar lichen sclerosus (LS) have an increased risk of developing differentiated vulvar intraepithelial neoplasia and vulvar squamous cell carcinoma (SCC). Our primary aim was to determine the prevalence of LS among women with vulvar SCC. All patients who underwent excision for invasive SCC of the vulva from January 1, 2009 to December 31, 2013 were identified by searching our institution's electronic laboratory information system (n=111). The vulvar excision specimens from these patients were reviewed for the presence of adjacent LS...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27801759/endometrial-stromal-sarcoma-arising-in-colorectal-endometriosis
#6
Rania Kilzieh, Natalia Rakislova, Aureli Torné, Rafael Salvador, Alfons Nadal, Jaume Ordi, Adela Saco
The malignant transformation of endometriosis is very uncommon. Whereas 75% of tumors arising from endometriosis arise in the ovary, location in extra-genital organs is rare and mesenchymal neoplasms are exceptional. A 47 year-old woman who underwent hysterectomy with bilateral salpingo-ooforectomy due to endometriosis 13 years before presented with abdominal pain. The magnetic resonance imaging (MRI) showed a 9.7×7.5 cm solid-cystic supravesical mass and a recto-vaginal tumor, as well as endometriotic nodules in the sigma, right parametrium and peritoneum that had significantly increased in size over a six months period...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27801758/metastatic-urothelial-carcinoma-to-the-uterine-cervix-a-case-report-of-a-rare-entity-and-review-of-the-diagnostic-differential
#7
Sharon B Sams, Julie A Rosser
Urothelial carcinoma (UC) rarely metastasizes to the gynecologic tract, occurring in descending order of frequency, within the vagina, uterus, ovaries, and cervix. Significant morphologic overlap exists between primary gynecologic squamous lesions (both benign and malignant) and metastatic UC, thus potentially hindering a timely and accurate diagnosis. We present a case of UC metastatic to the uterine cervix in a 69-year-old female initially found to have noninvasive high-grade papillary UC of the bladder. Complaints of vaginal spotting lead to identification and biopsy of a mass in the uterine cervix...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27801757/borderline-mucinous-tumor-with-granulosa-cell-proliferation
#8
Abhijit Chougule, Priya Singh
No abstract text is available yet for this article.
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27801756/ovarian-epithelial-inclusions-with-mucinous-differentiation-a-clinicopathologic-study-of-42-cases
#9
Jeffrey D Seidman, Jayashree Krishnan
Ovarian epithelial inclusions lined by mucinous epithelium are rare and of uncertain origin. Ovaries containing such inclusions were studied in 42 women. The inclusions were divided into 3 groups: serous epithelial lined with typical ciliated morphology but with distinct basophilic cytoplasmic mucin in some or all of the lining cells, those lined by typical mucinous epithelium, and those lined by a combination of typical mucinous epithelium and serous epithelium. The mean patient age was 61.5 years. Pure mucinous inclusions were found in 27 patients, serous-type inclusions with cytoplasmic mucin in 20, and mixed type in 10...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27801755/the-fallopian-tube-origin-and-primary-site-assignment-in-extrauterine-high-grade-serous-carcinoma-findings-of-a-survey-of-pathologists-and-clinicians
#10
W Glenn McCluggage, Lynn Hirschowitz, C Blake Gilks, Nafisa Wilkinson, Naveena Singh
Accumulating recent evidence suggests that the majority of extrauterine high-grade serous carcinomas (HGSCs) do not arise from the ovary as historically accepted but from the distal, fimbrial end of the fallopian tube from a precursor known as serous tubal intraepithelial carcinoma. There has been variable acceptance of this evidence among pathologists and clinicians dealing with "ovarian" cancer and this has resulted in wide variation in the assignment of primary site between different institutions when HGSC involves >1 anatomic site...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27801754/intratumoral-vasculopathy-in-leiomyoma-treated-with-tranexamic-acid
#11
Satoru Kudose, Hannah R Krigman
Although intravascular thrombi and infarct-type necrosis have been reported in leiomyomas following with tranexamic acid therapy, intratumoral vasculopathy resembling acute atherosis has not been reported to date in patients without exposure to gonadotropin receptor agonist. We describe a case of intratumoral vasculopathy resembling acute atherosis in a leiomyoma in a 49-year-old woman, with hereditary hemorrhagic telangiectasia and menorrhagia, treated with tranexamic acid. The patient had no exposure to gonadotropin receptor agonists...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27750257/granular-cell-tumor-within-an-ovarian-mature-cystic-teratoma-report-of-a-unique-case-and-review-of-the-literature
#12
Samuel G Borak, John R Ross, Walter C Bell
Granular cell tumors involving the female reproductive tract are rare, with only a small number of cases described. Of the reported cases, none are documented within an ovarian mature cystic teratoma (MCT). This report documents a case of a granular cell tumor, incidentally discovered within an ovarian MCT in a 50-yr-old woman undergoing a supracervical hysterectomy and left salpingo-oophorectomy. Although malignant transformation and other secondary ovarian neoplasms in MCT have been well documented, synchronous nonovarian benign neoplasms are reported much less frequently...
October 12, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27684885/primary-ovarian-malignant-pecoma-a-case-report
#13
Joseph D Westaby, Nesreen Magdy, Cyril Fisher, Mona El-Bahrawy
Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal neoplasm characterized by expression of both melanocytic and smooth muscle markers. PEComas are rarely encountered in the female genital tract. We here report a case of malignant primary PEComa of the ovary, and discuss the differential diagnosis. This represents the first case of primary typical malignant PEComa of the ovary.
September 28, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27684884/synchronous-low-grade-appendiceal-mucinous-neoplasm-and-primary-peritoneal-low-grade-serous-carcinoma-a-first-description-of-these-2-neoplasms-presenting-together-as-suspected-peritoneal-carcinomatosis
#14
Miroslav Sekulic, Simona Pichler Sekulic, Saeid Movahedi-Lankarani
Low-grade appendiceal mucinous neoplasm is a neoplasm typically of appendiceal origin, which is characterized by diffuse peritoneal involvement by pools of mucin with mucinous epithelium lacking high-grade cytologic atypia, and clinically presents as suspected peritoneal carcinomatosis. A similar clinical presentation can sometimes be seen with disseminated low-grade serous carcinomas of the peritoneum, fallopian tubes, or ovaries; however, this neoplasm is histologically characterized by tubal-type epithelium and invasive or confluent growth...
September 28, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27662036/primary-mucinous-carcinoma-of-the-fallopian-tube-case-report-and-review-of-literature
#15
Abigail Wheal, Robert Jenkins, Yoshiki Mikami, Nagindra Das, Lynn Hirschowitz
Primary mucinous carcinoma of the fallopian tube is extremely rare. We report the detailed characterization of a mucinous carcinoma arising in the fimbrial end of the fallopian tube in a 74-yr-old woman. The patient presented with recurrent urinary tract infection and urinary tract obstruction secondary to a large right ovarian mass. She had an appendicectomy as an 11 yr old. Serum CA-125 was raised at 239 U/mL. Computed tomographic scans showed bilateral, cystic ovarian tumors but no other intra-abdominal abnormality...
September 22, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27662035/frequent-nfib-associated-gene-rearrangement-in-adenoid-cystic-carcinoma-of-the-vulva
#16
Deyin Xing, Salwa Bakhsh, Nataliya Melnyk, Christina Isacson, Julie Ho, David G Huntsman, C Blake Gilks, Brigitte M Ronnett, Hugo M Horlings
Adenoid cystic carcinoma is a rare malignant tumor that usually arises in the major and minor salivary glands and other locations containing secretory glands, including the lower female genital tract. Lower female genital tract carcinomas with adenoid cystic differentiation can be subclassified into 2 distinct groups based on the presence or absence of high-risk HPV. Cervical mixed carcinomas with some adenoid cystic differentiation are high-risk HPV-related but pure adenoid cystic carcinomas of vulvar and cervical origin appear to be unrelated to high-risk HPV...
September 22, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27648785/composite-serous-borderline-tumor-and-adult-granulosa-cell-tumor-like-area-is-it-a-true-neoplastic-agct-or-tumor-like-proliferation
#17
Jun Yu, Xiu Nie
We report the 402C-G FOXL2 mutation status in 1 epithelial ovarian lesion in a 38-yr-old woman showing stromal proliferations that were morphologically indistinguishable from adult granulosa cell tumor (AGCT). The lesion was a serous borderline tumor. The AGCT-like components were distributed within the septa and cyst walls. FOXL2 mutation was absent. The combination of an epithelial neoplasm and AGCT-like areas is rare but described. The AGCT-like components are likely to be tumor-like proliferations but not truly neoplastic AGCT...
September 17, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27636888/alk-rearranged-inflammatory-myofibroblastic-tumor-of-the-placenta-with-observations-on-site-of-origin
#18
J Kenneth Schoolmeester, William R Sukov
No abstract text is available yet for this article.
September 15, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27636887/dna-genotyping-of-suspected-partial-hydatidiform-moles-detects-clinically-significant-aneuploidy
#19
Terence J Colgan, Martin C Chang, Shabin Nanji, Elena Kolomietz
The diagnosis of partial hydatidiform mole (PM) is especially difficult early in gestation as the morphology of nonmolar abortus (NMA) may mimic PM. Molecular genotyping analysis can definitively identify diandric triploidy, the genetic basis for PM, whereas NMA cases show a biparental inheritance. This 4-year retrospective study sought to determine what proportion of NMA cases which were initially suspected as being PM was aneuploid, and whether this knowledge of aneuploidy status is clinically useful. Cases with atypical villous morphology on histopathology suggestive of PM were subjected to molecular genotyping...
September 15, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27636886/mature-and-immature-solid-teratomas-involving-uterine-corpus-cervix-and-ovary
#20
Simona Stolnicu, Emoke Szekely, Calin Molnar, Claudiu V Molnar, Iulia Barsan, Valeria D'Alfonso, Cosmin Moldovan, Gang Zheng, Brigitte M Ronnett, Robert A Soslow
Extragonadal teratomas are rare, and localization in the endometrium and cervix is exceptional, with fewer than 10 case reports documented so far in the English literature. We report here the case of a 46-year-old patient who presented with simultaneous immature teratoma in the endometrium and mature teratomas in the ovary in association with gliomatosis peritonei but with no evidence of gestational origin; she subsequently developed multiple solid mature teratomas in the cervix and parauterine tissue. No other similar cases have been previously reported to our knowledge...
September 15, 2016: International Journal of Gynecological Pathology
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