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International Journal of Gynecological Pathology

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https://www.readbyqxmd.com/read/28914675/ganglioneuroblastoma-arising-in-an-ovarian-dermoid-cyst-first-report-in-the-literature
#1
Simon Rajendran, Debra Jensen, W Glenn McCluggage
The development of a somatic neoplasm within an ovarian dermoid cyst (mature cystic teratoma) is a rare, but well described, phenomenon which occurs in approximately 1% of all cases. Any of the tissue components of a dermoid cyst has the potential to undergo neoplastic transformation with carcinoid tumors and squamous cell carcinomas being among the most common neoplasms. We report a case of a ganglioneuroblastoma arising within an ovarian dermoid cyst, an association which, as far as we are aware, has not been described previously...
September 13, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28914674/frequent-pd-l1-expression-in-malignant-melanomas-of-the-vulva
#2
Banafsheh Saleh, Jörg Kriegsmann, Stephan Falk, Sebastian Aulmann
Blockade of immune checkpoint pathways such as the programmed cell death protein 1 pathway (PD-1/PD-L1) is an emerging approach in the treatment of solid tumors. In malignant melanoma, the efficiacy of antibodies against PD-L1 has been shown to be associated with PD-L1 protein expression. To evaluate whether this approach may be of use in the rare cases of primary melanoma of the vulva, we have evaluated a series of 13 cases for PD-L1 expression as well as additional molecular alterations of KIT, NRAS, KRAS, and BRAF...
September 13, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28914673/nodular-hyperplasia-of-the-bartholin-gland-a-benign-mimicker-of-aggressive-angiomyxoma-a-case-series-and-literature-review
#3
Yun-An Tseng, W Dwayne Lawrence, Shahrzad E Slater
Nodular hyperplasia (NH) of the Bartholin gland is an exceedingly rare benign solid lesion of the female genital tract that can mimic the Bartholin gland cyst clinically. The histologic criteria for NH were established in 1998 by Koenig and Tavassoli. In this case series, we describe 4 cases of NH from Women and Infants Hospital in Rhode Island. All cases have microscopic features of lobular proliferation of acini and inspissated mucin. One case especially has extensive mucin extravasation mimicking an aggressive angiomyxoma...
September 13, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28914672/endometrial-changes-in-surgical-specimens-of-perimenopausal-patients-treated-with-ulipristal-acetate-for-uterine-leiomyomas
#4
Francisco F Nogales, Vicente Crespo-Lora, Nelly Cruz-Viruel, Clara Chamorro-Santos, Christine Bergeron
Ulipristal acetate (UPA) is used to treat leiomyomas, and its effect on the endometrium has been studied in biopsy material. Reversible histologic modifications were found, named progesterone receptor modulators-associated endometrial changes (PAEC). However, hysterectomies from patients treated with UPA have not been analyzed. For the first time, we examined surgical specimens from 100 leiomyoma-treated patients for UPA-related endometrial changes. We analyzed the distribution of lesions, involution after treatment, and the relationship between type and extent of lesions and dosage...
September 13, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28914671/endometrial-polyps-and-benign-endometrial-hyperplasia-present-increased-prevalence-of-dna-fragmentation-factors-40-and-45-dff40-and-dff45-together-with-the-antiapoptotic-b-cell-lymphoma-bcl-2-protein-compared-with-normal-human-endometria
#5
Tomasz Banas, Kazimierz Pitynski, Marcin Mikos, Joanna Cielecka-Kuszyk
DNA fragmentation factor 40 (DFF40) is a key executor of apoptosis. It localizes to the nucleus together with DNA fragmentation factor 45 (DFF45), which acts as a DFF40 inhibitor and chaperone. B-cell lymphoma (Bcl-2) protein is a proven antiapoptotic factor present in the cytoplasm. In this study, we aimed to investigate DFF40, DFF45, and Bcl-2 immunoexpression in endometrial polyps (EPs) and benign endometrial hyperplasia (BEH) tissue compared with that in normal proliferative endometrium (NPE) and normal secretory endometrium (NSE) as well as normal post menopausal endometrium (NAE)...
September 13, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28914670/endometrial-stromal-neoplasm-in-the-placenta-report-of-a-case-and-review-of-the-literature
#6
Debra S Heller, Fadi Hatem
Placental neoplasms involving the fetal membranes are exceptionally rare. In leiomyomas and endometrial stromal neoplasms, a uterine origin for nodules in the membranes is also a possibility. We present a case of an incidental endometrial stromal nodule found in the decidua of the free membranes and review the literature.
September 13, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28863073/fumarate-hydratase-mutations-and-alterations-in-leiomyoma-with-bizarre-nuclei
#7
Qing Zhang, Kate Poropatich, Julianne Ubago, Jia Xie, Xiuhua Xu, Norma Frizzell, Julie Kim, Beihua Kong, Jian-Jun Wei
Leiomyoma with bizarre nuclei (LM-BN), is a variant of uterine smooth muscle tumor with atypical histologic features. Although some LM-BN share several significant genetic alterations with leiomyosarcoma, including p16 and p53, the underlying tumorigenesis of LM-BN remains largely unknown. As we previously reported, LM-BN can be divided into 2 subtypes, type I and type II, based on different nuclear features. Type I LM-BN have similar histologic features as uterine smooth muscle tumors with fumarate hydratase (FH) alterations...
August 31, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28863072/ywhae-rearrangement-in-a-purely-conventional-low-grade-endometrial-stromal-sarcoma-that-transformed-over-time-to-high-grade-sarcoma-importance-of-molecular-testing
#8
Omonigho Aisagbonhi, Beth Harrison, Liena Zhao, Rebecca Osgood, Ivan Chebib, Esther Oliva
Low and high-grade endometrial stromal sarcomas (ESS) can be distinguished on a morphologic basis. Low-grade ESS is composed of oval cells that resemble normal proliferative-phase endometrial stroma, while the well-known high-grade ESS is composed of round cells growing in nests separated by delicate sinusoidal vasculature. Recurrent JAZF1 rearrangements have been reported to be most frequent in low-grade stromal sarcomas (up to 60%), while YWHAE rearrangements are characteristic of high-grade ESS. Herein, we report a case of a 45-yr-old woman with stage IA typical low-grade ESS who developed multiple abdominopelvic recurrences and lung metastases 15 mo after her primary tumor was resected...
August 31, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28863071/an-ovarian-adenocarcinoma-with-combined-low-grade-serous-and-mesonephric-morphologies-suggests-a-m%C3%A3-llerian-origin-for-some-mesonephric-carcinomas
#9
David B Chapel, Nancy M Joseph, Thomas Krausz, Ricardo R Lastra
Mesonephric carcinomas are rare adenocarcinomas of the female genital tract that occur most commonly in the uterine cervix. They are classically thought to arise from benign mesonephric remnants, and are rarely reported at other sites in the gynecologic tract. Here we present an interesting biphenotypic ovarian adenocarcinoma with intimately associated but distinct components of both low-grade serous carcinoma and mesonephric-like carcinoma. A serous borderline tumor was present adjacent to the invasive carcinoma, and no benign mesonephric precursors were identified...
August 31, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28863070/evaluation-of-microscopic-changes-in-fallopian-tubes-of-brca-mutation-carriers-by-morphometric-analysis-of-histologic-slides-a-preliminary-pilot-study
#10
Amnon Amit, Edmond Sabo, Yaniv Zohar, Einat Trugman, Irena Pranovich, Ari Reiss, Emad Matanes, Geula Klorin
Mutations in BRCA genes increase the risk of ovarian cancer, yet no method for early diagnosis is available. Some serous ovarian tumors are hypothesized to stem from cells of the fallopian tube fimbria. Using a novel method of computerized morphometry of the fimbrial epithelium, this study aimed to detect morphologic differences in noncancerous fimbriae between BRCA mutation carriers and noncarriers, and between healthy and serous ovarian cancer patients. Twenty-four fimbriae from healthy women (13 BRCA+, 11 BRCA-) and 21 fimbriae from women with serous ovarian cancer (10 BRCA+, 11 BRCA-), all reported as "normal" by hematoxylin and eosin examination, were subjected to computerized histomorphometric analysis...
August 31, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28863069/fibroepithelial-stromal-polyp-of-the-vulva-case-report-and-review-of-potential-histologic-mimickers
#11
Majed Pharaon, Joshua Warrick, Michael C Lynch
Vulvar tumors arising from submucosal connective tissue, some of which exhibit hormonal responsiveness, have many clinical and histologic overlapping characteristics. We present a case of a fibroepithelial stromal polyp arising from the vulva of a 22-year-old female. We review the differential diagnosis with an emphasis on distinguishing features of these uncommon neoplasms. Accurate diagnosis is essential as the extent of surgical resection and risk of local recurrence varies for these tumors.
August 31, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28863068/test-characteristics-of-specific-p16-clones-in-the-detection-of-high-grade-squamous-intraepithelial-lesions-hsil
#12
Alana F Shain, David C Wilbur, Mark H Stoler, Bradley J Quade, Christina S Kong
p16 immunohistochemistry is recommended by the CAP-ASCCP Lower Anogenital Squamous Terminology (LAST) Standardization Project for human papillomavirus associated Lesions as an adjunct to morphologic assessment in the diagnosis of high-grade squamous intraepithelial lesion. This study evaluates the performance of different p16 clones as compared with E6H4 (CINtec) in detecting high-grade squamous intraepithelial lesion. The 54 high-quality articles addressing the performance of p16 identified by work group 4 of the LAST Project were evaluated for: specific p16 clone, scoring method, number of cases, anatomic site, and histologic diagnoses...
August 31, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28863067/cervical-carcinoma-with-divergent-neuroendocrine-and-gastrointestinal-differentiation
#13
Kavita R Varma, David J Dabbs
Neuroendocrine carcinomas of the uterine cervix are rare tumors with aggressive behavior. They comprise <4% of cervical carcinomas. They may coexist with both adenocarcinoma and squamous cell carcinoma of cervix. Signet ring carcinoma of cervix is a rarer entity and less than 20 cases have been described in the literature. We present a case of a 34-year-old female who presented with systemic thrombosis, splenic mass and a cervical mass which on biopsy showed divergent differentiation of primitive large cell neuroendocrine carcinoma with signet ring cells...
August 31, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28863066/inflammatory-pseudotumor-presenting-as-a-mesosalpingeal-mass
#14
Simona Stolnicu, Robert A Soslow
We describe a case in which the clinical and pathologic features of a mesosalpingeal mass led to a diagnosis of inflammatory pseudotumor, an unusual tumor found in a rare location. The differential diagnosis is rather broad and includes lesions ranging from Castleman disease to an immunoglobulin G4-related fibrosclerosing tumor. The patient is alive and well at last follow-up.
August 31, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28863065/ovarian-leydig-cells-olc-about-their-heterotopia-or-eutopia
#15
Jose-Luis Carrasco-Juan, Hugo Álvarez-Argüelles Cabrera, Maria Del Carmen Martín Corriente, Francisco Valladares Parrilla, Ricardo Gutiérrez García, Lucio Díaz-Flores Feo
No abstract text is available yet for this article.
August 31, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28863064/mixed-tumor-eccrine-type-so-what-if-it-s-vulval
#16
Mani Makhija, Mahdieh Gorji, Marianne Kube
No abstract text is available yet for this article.
August 31, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28796747/morphologic-and-immunohistochemical-study-of-clear-cell-carcinoma-of-the-uterine-endometrium-and-cervix-in-comparison-to-ovarian-clear-cell-carcinoma
#17
Baohui Ju, Jianmei Wang, Bo Yang, Lin Sun, Yuhong Guo, Quan Hao, Jianghua Wu
Endometrial clear cell carcinoma (ECCC) and clear cell adenocarcinoma of the cervix (CCAC) are uncommon gynecologic cancers that have morphologic and phenotypic features similar to ovarian clear cell carcinoma (OCCC), but the 3 entities may not be completely identical. This study identified the morphologic and phenotypic characteristics and the differences between ECCC and CCAC in Comparison to OCCC. The morphologic features of 16 ECCCs, 7 CCACs, and 22 OCCCs are described. The immunoprofiles of hepatocyte nuclear factor (HNF) 1β, napsin A, estrogen, progesterone, p53, and Ki-67 were assessed...
August 7, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28787324/epithelioid-inflammatory-myofibroblastic-sarcoma-of-the-ovary-with-ranb2-alk-fusion-report-of-a-case
#18
Hong Fang, Carrie L Langstraat, Daniel W Visscher, Andrew L Folpe, J Kenneth Schoolmeester
Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a recently described, clinically aggressive variant of inflammatory myofibroblastic tumor with a predilection for intraabdominal sites, tendency to arise in male patients and resistance to conventional chemotherapy and radiotherapy. We present a case of a 15-year-old girl with EIMS of the ovary with a RANBP2-ALK fusion. During 2 years of follow up, she experienced multiple recurrences. Following classification of the tumor as EIMS, the patient began treatment with an ALK inhibitor (crizotinib), which led to disease improvement within weeks of administration...
August 4, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28787323/disease-distribution-in-low-stage-tubo-ovarian-high-grade-serous-carcinoma-hgsc-implications-for-assigning-primary-site-and-figo-stage
#19
Naveena Singh, Jack L Benson, Carmen Gan, Michael Anglesio, Rupali Arora, Asma Z Faruqi, Lynn Hirschowitz, Friedrich Kommoss, Kerry Scott, Giorgia Trevisan, Sarah Lam Shang Leen, Nafisa Wilkinson, C Blake Gilks, W Glenn McCluggage
The latest FIGO and TNM (eighth edition) staging systems for ovarian, tubal, and peritoneal neoplasms require primary site assignment as tubal/ovarian/peritoneal, but provide no guidance or criteria. Fewer than 10% of extrauterine high-grade serous carcinoma (HGSC) cases present at low stage (stage I/II). Low-stage cases offer a unique opportunity to understand the pattern of disease early in its evolution prior to wide dissemination and provide valuable evidence for guiding specimen handling and tumor staging...
August 4, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28787322/invasive-micropapillary-carcinoma-of-the-uterine-cervix-case-report-of-a-rare-entity
#20
Satoru Munakata, Ayako Hosoi, Toshiya Yamamoto
Invasive micropapillary carcinoma (IMPC) is a rare subtype of adenocarcinoma found in many organs. Only 1 case of IMPC of the uterine cervix has been reported. We report a rare case of IMPC in the uterine cervix. A 61-yr-old woman presented to our hospital for vaginal bleeding and abdominal pain. A papillary tumor was found in the uterine cervix. Cervical cytology revealed abnormal cells suggesting carcinoma in situ and adenocarcinoma. A follow up biopsy revealed adenocarcinoma. She underwent radical hysterectomy and bilateral adnexectomy...
August 4, 2017: International Journal of Gynecological Pathology
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