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International Journal of Gynecological Pathology

Shatrughan Sah, W Glenn McCluggage
Brenner tumors are uncommon ovarian neoplasms which occasionally occur in combination with a mucinous tumor. Rarely, the combination of Brenner tumor and thyroid tissue (struma ovarii) has been reported. We report an ovarian neoplasm with components of Brenner tumor, mucinous cystadenoma and struma ovarii. As far as we are aware, this combination has not been previously reported. We speculate on the possible histogenesis of this combination of elements.
August 21, 2018: International Journal of Gynecological Pathology
Nuran Sungu, Melahat Yildirim, Raziye Desdicioglu, Özge Başaran Aydoğdu, Aydan Kiliçarslan, Hayriye Tatli Doğan, Aylin Kiliç Yazgan, Mesut Akyol, Fazli Erdoğan
Chemotherapeutic agents are not very effective in treating advanced endometrial cancers (ECs). Recent studies have demonstrated the immune evasion mechanism of tumors and possible remedies. Programmed cell death protein 1 (PD-1), programmed death ligand 1 (PD-L1), and programmed death ligand 2 (PD-L2) are immunomodulator molecules that have been the focus of research in lung cancer, melanoma, and renal cell cancer. However, there are few studies concerning EC. This retrospective study aimed to determine PD-1, PD-L1, and PD-L2 expression immunohistochemically in EC, and to study their correlation with clinicopathologic tumor characteristics...
August 21, 2018: International Journal of Gynecological Pathology
Jelena Mirkovic, Fei Dong, Lynette M Sholl, Elizabeth Garcia, Neal Lindeman, Laura MacConaill, Christopher P Crum, Marisa R Nucci, W Glenn McCluggage, Brooke E Howitt
Female adnexal tumor of probable Wolffian origin (FATWO) is a rare gynecologic neoplasm of low-malignant potential presumed to be derived from mesonephric remnants in the upper female genital tract. Similarly, mesonephric remnants in the lower female genital tract are thought to be the origin for mesonephric carcinoma. Although the molecular alterations in mesonephric carcinoma have been recently reported, the pathogenesis of and molecular alterations in FATWO are not well understood. The aims of this study were to examine the molecular alterations in FATWO and to establish whether these neoplasms are molecularly similar to mesonephric carcinoma...
August 21, 2018: International Journal of Gynecological Pathology
Nicholas Wee Chong Koh, Wan Yi Seow, York Tien Lee, Joyce Ching Mei Lam, Derrick Wen Quan Lian
We report the first case of an ovarian pericytoma with t(7;12). An 11-year-old child presented with abdominal pain and distension. A suprapubic mass was detected on examination and radiological investigations revealed a 16.5 cm solid-cystic ovarian mass. Histologically, the tumor was composed of spindle cells with S100-protein, Bcl-2, and CD10 reactivity on immunohistochemistry. Alpha fetoprotein, calretinin, alpha-inhibin, WT1, smooth muscle actin, caldesmon, desmin, cytokeratins, chromogranin, synaptophysin, EMA, Sox10, CD117, CD31, CD34, and CD68 were all negative...
August 6, 2018: International Journal of Gynecological Pathology
W Glenn McCluggage, Koen Van de Vijver
So-called squamous morules are closely associated with endometrioid proliferative lesions, in the endometrium and the ovary. Morules have an unusual immunophenoptype, typically exhibiting nuclear staining with β-catenin, positivity with CDX2, CD10, and p16 and are negative with hormone receptors and p63. We report the previously undescribed occurrence of consistent SATB2 nuclear positivity within morules. Nuclear positivity was present in 38/43 (88%) cases of morules (24 focal; 14 diffuse) while all cases of nonmorular squamous metaplasia in endometrioid proliferative lesions (n=13) were SATB2 negative, except for occasional positive nuclei in 1 case...
August 6, 2018: International Journal of Gynecological Pathology
Yi-Ping Li, Koping Chang, Tom Wei-Wu Chen, Shu-Ping Lee, Chi-An Chen, Wen-Fang Cheng
Ewing sarcoma and peripheral primitive neuroectodermal tumor constitute the Ewing family of tumors (EFT). EFTs primarily arising in the ovary are extremely rare. We report the case of a 22-yr-old nulliparous woman with a primary EFT in the ovary that initially presented as a 3-cm teratoma-like ovarian tumor, with rapid progression to a 15-cm-sized tumor with liver metastasis in 3 mo. The patient underwent suboptimal debulking surgery and salvage chemotherapy with vincristine, doxorubicin, and cyclophosphamide alternating with ifosfamide and etoposide...
August 6, 2018: International Journal of Gynecological Pathology
Maysa Al-Hussaini, Isam Lataifeh, Imad Jaradat, Ghadeer Abdeen, Lian Otay, Osama Badran, Areej Abu Sheikha, Abdulmajeed Dayyat, Mousa El Khaldi, Shaymaa Ashi Al-Loh
Undifferentiated endometrial carcinoma (UEC) is a rare and poorly recognized entity, associated with a poor outcome. The clinical, pathologic, and immunohistochemical features of 17 cases diagnosed at our center are described. The median age was 60 yr. Postmenopausal bleeding was the most common presenting symptom (76.9%). Most patients presented with advanced stage (64.7%). Total hysterectomy with bilateral salpingo-oophorectomy was the commonly offered surgical treatment (80.0%). Nine (52.9%) patients received adjuvant treatment...
July 27, 2018: International Journal of Gynecological Pathology
Dina Bassiouny, Mahmoud A El-Baz, Tawakol M Gamil, Nazem Shams, Nadia Ismiil, Valerie Dubé, Guangming Han, Matthew Cesari, Fang-I Lu, Elzbieta Slodkowska, Hak Fai Chiu, Magda Naeim, Nim Li, Sharon Nofech-Mozes, Mahmoud A Khalifa
There is a controversy about whether endometriosis-associated ovarian cancer (EAOC) might represent a different entity from the corresponding ovarian cancer occurring de novo, in the absence of endometriosis. This study investigated the clinical-pathologic characteristics and outcome of EAOC compared with other ovarian carcinomas that are not associated with endometriosis (non-EAOC) in a large cohort. Seven hundred two patients meeting the inclusion criteria were further subclassified as group I when patients had ovarian carcinoma associated with or arising within endometriosis (EAOC) and group II when patients had non-EAOC...
July 27, 2018: International Journal of Gynecological Pathology
Tatjana Terzic, Anne M Mills, Sarah Zadeh, Kristen A Atkins, Krisztina Z Hanley
GATA binding protein 3 (GATA3) immunohistochemistry is primarily used as a marker of breast and urothelial differentiation, particularly in metastatic settings. In the gynecologic tract it also serves a robust marker for mesonephric and trophoblastic tumors. However, expression has also been described in more common malignancies of gynecologic tract including ovarian, endometrial, and cervical carcinomas. Data on the distribution of GATA3 expression in gynecologic malignancies is somewhat limited, particularly across different histologic subtypes of ovarian, endometrial, and cervical carcinomas...
July 27, 2018: International Journal of Gynecological Pathology
Aya Tokinaga-Uchiyama, Taichi Mizushima, Kazunori Akimoto, Yoji Nagashima, Kazunori Sasaki, Masa-Aki Nakaya, Kenichi Ohashi, Kazumi Kubota, Yasuyo Maruyama, Hisamori Kato, Fumiki Hirahara, Etsuko Miyagi, Shigeo Ohno, Mikiko Asai-Sato
We previously reported that aberrant expression of atypical protein kinase C λ/ι (aPKCλ/ι) in low-grade squamous intraepithelial uterine cervix lesions was associated with an increased risk of progression to higher grade. This study aimed to investigate aPKCλ/ι expression patterns in cervical squamous cell carcinoma (SCC) and its association with disease progression. We immunohistochemically assessed aPKCλ/ι expression in 168 SCC samples and 13 normal uterine cervix samples. In 69.0% of SCC cases, aPKCλ/ι was expressed more abundantly than in normal epithelium, but there was no significant association between aPKCλ/ι intensity and disease progression (P=0...
July 27, 2018: International Journal of Gynecological Pathology
Jamie Magrill, Anthony N Karnezis, Basile Tessier-Cloutier, Aline Talhouk, Stefan Kommoss, Dawn Cochrane, Christine Chow, Angela Cheng, Robert Soslow, Steffen Hauptmann, Andreas du Bois, Jacobus Pfisterer, C Blake Gilks, David G Huntsman, Friedrich Kommoss
Tubo-ovarian transitional cell carcinoma (TCC) is grouped with high-grade serous carcinoma (HGSC) in the current World Health Organization classification. TCC is associated with BRCA mutations and a better prognosis compared with HGSC. Previous papers examining the immunohistochemical features of TCC have studied limited numbers of samples. No marker reflecting the biological difference between TCC and HGSC is known. We collected a large cohort of TCC to determine whether TCC and HGSC could be distinguished by immunohistochemistry...
July 27, 2018: International Journal of Gynecological Pathology
Gaurav Muktesh, Suvradeep Mitra, Saroj K Sinha, Narendra Dhaka, Uma N Saikia, Phulen Sarma, Ajay Gulati, Jayanta Samanta, Rakesh Kochhar
Choriocarcinoma is an aggressive gestational trophoblastic neoplasia known for its widely metastatic potential. However, isolated pancreatic metastasis is an extremely rare occurrence and has not been documented in the English literature to the best of our knowledge. The metastatic deposits in the index case led to widespread hemorrhage and necrosis of the pancreatic parenchyma, causing severe acute pancreatitis. The patient succumbed to her illness before chemotherapy was administered. Thus, we present an autopsy case of a uterine choriocarcinoma with isolated pancreatic metastasis presenting as severe acute pancreatitis in a 27-yr-old woman following a molar pregnancy...
July 18, 2018: International Journal of Gynecological Pathology
Imran Hussain, Robin S Howard, Viqar Syed, Michael Allgäuer, Heping Gong, Deyin Xing, John D Andersen
TP53 gene mutations are known to manifest in distinct p53 immunohistochemical staining patterns; overexpression, wild-type, and null. These stratified staining patterns are routinely utilized in subtyping ovarian cancer subtypes. Three ovarian cancer cell lines were used in the construction of an immunohistochemical p53 expression pattern control panel that highlight respective TP53 mutation status. The cell line control panel sections demonstrated consistent clean and easily interpretable p53 immunohistochemical staining...
July 18, 2018: International Journal of Gynecological Pathology
Youn Jin Choi, Jungyoon Ho, Jigeun Yoo, Jingjing Liu, Ahwon Lee, Jong Sup Park, Soo Young Hur
Ovarian spindle cell tumors comprise a heterogeneous group of ovarian neoplasms from benign to malignant. Since this morphologic finding describes a broad category of ovarian neoplasms, it is not easy to determine an accurate diagnosis. Low-grade endometrial stromal sarcoma (LG-ESS) is a rare gynecological malignancy that presents with spindle cell lesions. To identify ovarian LG-ESS, we performed whole-exome sequencing and transcriptome sequencing of a spindle cell tumor. The tumor harbored JAZF1-SUZ12, a well-known gene fusion commonly found in uterine LG-ESS...
July 18, 2018: International Journal of Gynecological Pathology
Mertihan Kurdoglu, Zehra Kucukaydin, Zehra Kurdoglu, Gulay Bulut, Yasar Unlu, Suleyman Ozen
Laminin receptor 1 may have a role in the progression from endometrial hyperplasia with or without atypia to endometrial cancer. Therefore, we aimed to investigate the pattern, percentage, and intensity of laminin receptor 1 expression in normal, hyperplastic, and neoplastic endometrium. Paraffin blocks of 131 specimens with the diagnoses of normal endometrium (n=25), endometrial hyperplasia with atypia (n=21) or without atypia (n=55), and endometrial cancer (n=30) were immunostained with laminin receptor 1 antibody, and its expression percentage, pattern, and intensity in the epithelial cytoplasm, basement membrane, and endometrial stroma of these tissues were assessed...
July 18, 2018: International Journal of Gynecological Pathology
Vikarn Vishwajeet, Nirmalya Banerjee, Pranab Dey
Ovarian lipoleiomyoma is an extremely rare neoplasm and may pose a diagnostic challenge for clinicians, radiologists, and pathologists. It is rarely described as case reports in the literature; almost all patients are late middle aged or elderly. Hereby, we encountered a 57-yr-old postmenopausal woman who presented with abdominal pain. Radiologic investigation revealed a heterogenous nonenhancing mass in the left adnexa, suggestive of dermoid cyst. Microscopic examination showed clusters of adipocytes intersecting the fascicles of smooth muscles, diagnostic of lipoleiomyoma...
July 10, 2018: International Journal of Gynecological Pathology
Chelsey C Spriggs, Luis Z Blanco, Kruti P Maniar, Laimonis A Laimins
Human papillomaviruses (HPVs) are DNA viruses with epithelial tropism. High-risk types of HPV are the causative agents of the majority of cervical cancers and are responsible for a number of other anogenital as well as oropharyngeal cancers. The life cycle of HPV is closely linked to the differentiation state of its host cell and is dependent on the activation of specific pathways of the DNA damage response. Several proteins from the ataxia telangiectasia mutated and the ataxia telangiectasia mutated and Rad3-related DNA repair pathways, which are essential for maintaining genomic stability in cells, are upregulated in HPV-positive cells and are required for viral replication...
July 10, 2018: International Journal of Gynecological Pathology
Sarah V Strickland, Mara H Rendi, Rochelle L Garcia, Barbara S Norquist, Kathryn P Pennington, Mark R Kilgore
Intraoperative assessment (IA) of uteri is often used to help determine whether to perform lymphadenectomy in patients with endometrial carcinoma. We sought to perform a quality assurance review of the practice of IA at our institution. In a 1-yr period, 107 hysterectomies had an IA performed. Grade of neoplasm in preoperative endometrial biopsy, neoplasm size, depth of myometrial invasion at IA, operative management, and final histologic features were recorded. Operative reports were reviewed to assess the surgeon's interpretation of the IA and the effect on surgical management...
September 2018: International Journal of Gynecological Pathology
Robert H Young, Philip B Clement
No abstract text is available yet for this article.
September 2018: International Journal of Gynecological Pathology
Valentina Sangiorgio, Vanna Zanagnolo, Giovanni Aletti, Luca Bocciolone, Simone Bruni, Fabio Landoni, Nicoletta Colombo, Angelo Maggioni, Enzo Ricciardi
Cervical sarcomas are rare neoplasms, accounting for <1% of all cervical malignancies and characterized by an aggressive course despite radical excision. We report the clinical and microscopic features of a spindle cell sarcoma arising as a polypoid endocervical mass in a 45-yr-old woman. The neoplasm was characterized by a monotonous, mildly atypical proliferation of spindle cells, displaying a fibrosarcoma-like parallel pattern of highly dense fascicles, growing under the cervical epithelium. Mitotic activity was conspicuous, with up to 40 mitoses per 10 HPF...
September 2018: International Journal of Gynecological Pathology
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