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International Journal of Gynecological Pathology

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https://www.readbyqxmd.com/read/30394942/does-ki-67-have-a-role-in-the-diagnosis-of-placental-molar-disease
#1
Rofieda Alwaqfi, Martin C Chang, Terence J Colgan
The use of p57 immunohistochemistry (IHC) can distinguish complete mole (CM) from partial mole (PM) and nonmolar abortus (NMA). Molecular genotyping (MG) is the gold standard method for the definitive diagnosis of PM and NMA. However, MG is expensive and not always available. Some data suggest Ki-67 IHC may be helpful in distinguishing NMAs from PMs and could be a substitute for MG. In this study, we examined the utility of p57 and Ki-67 IHC stains in the diagnosis of placental molar disease. The study cohort consisted of 60 cases of products of conception (20 CMs, 20 PMs, and 20 NMAs)...
November 1, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30383612/potential-diagnostic-pitfalls-in-evaluating-immunohistochemistry-for-cervical-myofibroblastomas
#2
Sharon Song, Amy Ziober, Kumarasen Cooper
Cervicovaginal myofibroblastoma (CVM) is a rare benign mesenchymal tumor of the lower female genital tract that shows chromosomal loss of 13q14 (RB1 gene located in this region). The aim of this study was to investigate the utility of immunohistochemistry (IHC) for desmin, CD34, and Rb in diagnosing CVM. All cervical polyps diagnosed from July 2016 to July 2017 were retrospectively reviewed. Cases showing morphologic myofibroblastic differentiation were evaluated by IHC for desmin, CD34, and Rb. Desmin and CD34 staining was recorded as positive or negative...
October 31, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30383611/peritoneal-carcinomatosis-from-yolk-sac-tumor-in-a-postmenopausal-woman-following-chemotherapy-for-high-grade-ovarian-serous-carcinoma
#3
Giuseppe Angelico, Angela Santoro, Damiano Arciuolo, Michele Valente, Vittoria Carbone, Anna Fagotti, Giovanni Scambia, Gian Franco Zannoni
No abstract text is available yet for this article.
October 31, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30383610/mismatch-repair-protein-expression-in-endometrioid-intraepithelial-neoplasia-atypical-hyperplasia-should-we-screen-for-lynch-syndrome-in-precancerous-lesions
#4
Elena Lucas, Hao Chen, Kyle Molberg, Diego H Castrillon, Glorimar Rivera Colon, Long Li, Stacy Hinson, Joel Thibodeaux, Jayanthi Lea, David S Miller, Wenxin Zheng
Screening for Lynch syndrome (LS) is routinely performed in patients with endometrial carcinoma. Currently, no screening recommendations exist for LS in precancerous lesions. The study goal was to determine the incidence of abnormal protein expression in endometrioid intraepithelial neoplasia/atypical hyperplasia (EIN/AH). We analyzed mismatch repair (MMR) protein expression by immunohistochemistry in EIN/AH concurrent with MMR-deficient endometrial carcinomas, and in endometrial biopsy/curettage specimens with EIN/AH from an unselected group of patients...
October 31, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30383609/tubulovillous-adenoma-of-vagina-with-both-kras-and-apc-mutations-case-report
#5
Somruetai Shuangshoti, Chinachote Teerapakpinyo
Adenomatous polyps of the vulva and vagina are extremely rare. We report a case of a 74-yr-old women with a tubulovillous adenoma occurring in the vagina, and a second one occurring later in the vulva. Tumor cells in both lesions were CK7, CK20, CDX-2, and showed intact mismatch-repair proteins. A G13D (c.38G>A, p.Gly13Asp) mutation in the KRAS gene was identified in both masses. As well, a novel frameshift truncating mutation (c.4320delA, p.Pro1441fsTer32) in the APC gene was detected only in the vaginal mass, ruling out the possibility that the vulvar mass was a local recurrence of the vaginal mass...
October 31, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30358638/multiple-luteinized-follicle-cysts-of-the-ovary-in-a-patient-with-a-pituitary-adenoma-report-of-a-case-and-review-of-the-literature
#6
Patrick Lebok, Rosemary E Zuna, Laura L Holman, Robert H Young
The case of a 36-yr-old woman with a pituitary adenoma who was found to have bilateral ovarian masses is reported. The right ovary was removed, measured 15 cm in maximum dimension, and contained multiple cysts which on microscopic examination had the typical morphology of follicle cysts. The left ovary was grossly similar intraoperatively. Subsequent excision of the pituitary adenoma was followed ∼3 mo later by a return to normal size of the left ovary. The case represents an example of multiple luteinized follicle cysts, analogous to the phenomenon seen occasionally in pregnancy, but with a different clinical background...
October 24, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30312218/hpv-6-associated-hsil-squamous-carcinoma-in-the-anogenital-tract
#7
Martina Z Liu, Yin P Hung, Eric C Huang, Brooke E Howitt, Marisa R Nucci, Christopher P Crum
Human papillomavirus (HPV) type 6 is historically classified as low-risk HPV type and associates with low-grade squamous intraepithelial lesions of the anogenital tract. Rare squamous carcinomas have been reported in association with these HPV types but the mechanism(s) behind this carcinogenic sequence have been unclear. We report 4 cases of low risk anogenital HPV infections-3 cervical (immature low-grade squamous intraepithelial lesion with metaplastic phenotype) and one anal (exophytic condyloma) lesion-that manifested with high-grade squamous intraepithelial lesion/squamous cell carcinoma...
October 11, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30256235/pi3k-pathway-effectors-pakt-and-foxo1-as-novel-markers-of-endometrioid-intraepithelial-neoplasia
#8
Amanda L Strickland, Glorimar Rivera, Elena Lucas, George John, Ileana Cuevas, Diego H Castrillon
The diagnosis of endometrioid intraepithelial neoplasia (EIN) is challenging owing to limited sampling, hormonal status, and other confounding histologic variables. Markers such as PTEN or PAX2 can delineate EIN in some cases, but are not wholly reliable. Clearly, new markers of EIN are needed. We explored several potential markers of EIN based rationally on molecular pathways most frequently misregulated in endometrial cancer: the 3-phosphoinositide kinase (PI3K)/AKT, β-catenin, and mismatch repair pathways...
September 25, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30252730/classic-and-dissecting-gonadoblastoma-in-a-phenotypic-girl-with-a-46-xx-peripheral-karyotype-and-no-evidence-of-a-disorder-of-sex-development
#9
Lawrence M Roth, Mary M Davis, Bernard Czernobilsky
Herein, we report a case of a 9-yr-old girl who had a 46, XX peripheral karyotype and apparent developmentally normal ovaries. She presented with abdominal pain and a right adnexal mass. No clinical or pathologic evidence of gonadal dysgenesis or undifferentiated gonadal tissue was detected. She underwent right salpingo-oophorectomy with rupture of the tumor at the time of operation due to recent adnexal torsion. The original pathologic diagnosis was gonadoblastoma and mixed germ cell tumor. Most significantly in our study, we identified a rare and novel pathway for the development of malignant mixed germ cell tumor from gonadoblastoma in the absence of identifiable dysgerminoma...
September 24, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30252729/audit-of-endometrial-cancer-pathology-for-a-regional-gynaecological-oncology-multidisciplinary-meeting
#10
Emma Spoor, Paul Cross
Endometrial cancer is a common disease, and in England all cancer cases are discussed at a central multidisciplinary meeting (MDT) with pathology review. We reviewed cases discussed/reviewed at a regional Gynecology MDT comparing (i) original referral histology with review histology and (ii) final review histology with the final hysterectomy histology. Cases identified as potentially eligible for the study (n=884) were found over a 4-yr period. This was reduced to 630 due to data and other issues for the primary biopsy review, and to 488 for both biopsy and hysterectomy sample...
September 24, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30252728/histologic-features-of-hysterectomy-specimens-from-female-male-transgender-individuals
#11
Mahmoud A Khalifa, Aimi Toyama, Molly E Klein, Victor Santiago
Histologic changes in the female genital tract after prolonged androgen stimulation have been described in the past. However, these changes have not been systematically addressed in hysterectomy specimens from subjects undergoing surgical gender-reassignment, typically after treatment with exogenous androgens. The current study aims to provide practicing pathologists with a list of expected histologic features in hysterectomy specimens from female-male transgender individuals. Twenty-seven hysterectomy with bilateral salpingo-oophorectomy specimens were identified from our Laboratory Information System...
September 24, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30252727/cerebellar-metastasis-from-ovarian-carcinoma-harboring-pik3ca-activating-mutation-a-clear-explanation-for-an-unexpected-vertigo
#12
Alessia Piermattei, Angela Santoro, Giuseppe Angelico, Frediano Inzani, Michele Valente, Angela Pettinato, Simona Vatrano, Giovanni Scambia, Filippo Fraggetta, Gian Franco Zannoni
Brain metastasis is a rare and generally late manifestation of an advanced-stage, high-grade serous ovarian carcinoma. Nowadays, the improved control of intra-abdominal disease by surgery and platinum-based chemotherapy results in a longer survival, allowing distant metastasis to implant and grow in the brain parenchyma also. Herein, we describe a unique case of cerebellar metastasis from a particular type of ovarian tumor, clear cell that initially presented as a FIGO Stage IC cancer. Surprisingly, 6 mo after surgery, the patient shows good general conditions with complete disappearance of symptoms and no evidence of recurrence...
September 24, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30252726/ywhae-nutm2a-b-translocated-high-grade-endometrial-stromal-sarcoma-commonly-expresses-cd56-and-cd99
#13
W Glenn McCluggage, Cheng-Han Lee
YWHAE-NUTM2A/B translocated high-grade endometrial stromal sarcoma is an uncommon and clinically aggressive uterine mesenchymal neoplasm which is sometimes associated with a low-grade fibromyxoid component. Although the diagnosis is confirmed using molecular techniques, it is possible to make the diagnosis based on the characteristic morphology and the immunophenotype; the latter typically includes diffuse positive staining of the high-grade component with cyclin D1 and CD117 and negative staining with CD10 and hormone receptors...
September 24, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30134344/ovarian-combined-brenner-tumor-mucinous-cystadenoma-and-struma-ovarii-first-report-of-a-rare-combination
#14
Shatrughan Sah, W Glenn McCluggage
Brenner tumors are uncommon ovarian neoplasms which occasionally occur in combination with a mucinous tumor. Rarely, the combination of Brenner tumor and thyroid tissue (struma ovarii) has been reported. We report an ovarian neoplasm with components of Brenner tumor, mucinous cystadenoma and struma ovarii. As far as we are aware, this combination has not been previously reported. We speculate on the possible histogenesis of this combination of elements.
August 21, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30134343/expression-of-immunomodulatory-molecules-pd-1-pd-l1-and-pd-l2-and-their-relationship-with-clinicopathologic-characteristics-in-endometrial-cancer
#15
Nuran Sungu, Melahat Yildirim, Raziye Desdicioglu, Özge Başaran Aydoğdu, Aydan Kiliçarslan, Hayriye Tatli Doğan, Aylin Kiliç Yazgan, Mesut Akyol, Fazli Erdoğan
Chemotherapeutic agents are not very effective in treating advanced endometrial cancers (ECs). Recent studies have demonstrated the immune evasion mechanism of tumors and possible remedies. Programmed cell death protein 1 (PD-1), programmed death ligand 1 (PD-L1), and programmed death ligand 2 (PD-L2) are immunomodulator molecules that have been the focus of research in lung cancer, melanoma, and renal cell cancer. However, there are few studies concerning EC. This retrospective study aimed to determine PD-1, PD-L1, and PD-L2 expression immunohistochemically in EC, and to study their correlation with clinicopathologic tumor characteristics...
August 21, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30134342/targeted-genomic-profiling-of-female-adnexal-tumors-of-probable-wolffian-origin-fatwo
#16
Jelena Mirkovic, Fei Dong, Lynette M Sholl, Elizabeth Garcia, Neal Lindeman, Laura MacConaill, Christopher P Crum, Marisa R Nucci, W Glenn McCluggage, Brooke E Howitt
Female adnexal tumor of probable Wolffian origin (FATWO) is a rare gynecologic neoplasm of low-malignant potential presumed to be derived from mesonephric remnants in the upper female genital tract. Similarly, mesonephric remnants in the lower female genital tract are thought to be the origin for mesonephric carcinoma. Although the molecular alterations in mesonephric carcinoma have been recently reported, the pathogenesis of and molecular alterations in FATWO are not well understood. The aims of this study were to examine the molecular alterations in FATWO and to establish whether these neoplasms are molecularly similar to mesonephric carcinoma...
August 21, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30300259/xxxi-julius-schottlaender
#17
Hellmuth Pickel, Elena Brachtel, Robert H Young
No abstract text is available yet for this article.
November 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/30059455/undifferentiated-endometrial-carcinoma-an-immunohistochemical-study-including-pd-l1-testing-of-a-series-of-cases-from-a-single-cancer-center
#18
Maysa Al-Hussaini, Isam Lataifeh, Imad Jaradat, Ghadeer Abdeen, Lian Otay, Osama Badran, Areej Abu Sheikha, Abdulmajeed Dayyat, Mousa El Khaldi, Shaymaa Ashi Al-Loh
Undifferentiated endometrial carcinoma (UEC) is a rare and poorly recognized entity, associated with a poor outcome. The clinical, pathologic, and immunohistochemical features of 17 cases diagnosed at our center are described. The median age was 60 yr. Postmenopausal bleeding was the most common presenting symptom (76.9%). Most patients presented with advanced stage (64.7%). Total hysterectomy with bilateral salpingo-oophorectomy was the commonly offered surgical treatment (80.0%). Nine (52.9%) patients received adjuvant treatment...
November 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29140881/pdgfb-rearrangements-in-dermatofibrosarcoma-protuberans-of-the-vulva-a-study-of-11-cases-including-myxoid-and-fibrosarcomatous-variants
#19
Khadijeh Jahanseir, Deyin Xing, Patricia T Greipp, William R Sukov, Gary L Keeney, Brooke E Howitt, J Kenneth Schoolmeester
Dermatofibrosarcoma protuberans (DFSP) is a low-grade fibroblastic sarcoma that tends to arise in young to middle age adults and involve the trunk and proximal extremities. Rare examples of vulvar DFSP have been reported, including myxoid, myoid, and fibrosarcomatous variants, but detection of the characteristic t(17;22)(q22;q13) that produces COL1A1-PDGFB gene fusion has not been evaluated in a large series of primary vulvar tumors. The clinical, morphologic, immunohistochemical, and molecular cytogenetic features of 11 cases were examined...
November 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29140879/metastatic-endocervical-adenocarcinoma-in-a-mature-cystic-teratoma-a-case-of-a-tumor-to-tumor-metastasis
#20
Filipa Santos, Catarina Oliveira, João P Caldeira, Ana Coelho, Ana Félix
Tumor-to-tumor metastasis is a rare phenomenon defined as a metastasis in a histologically distinct tumor. We report an unusual case of a 51-yr-old woman who presented with a cervical, bleeding lesion diagnosed as a poorly differentiated adenocarcinoma, HPV18+. Imaging studies revealed an unresectable cervical carcinoma with an associated left ovarian multicystic teratoma. A suspicious solid nodule within the teratoma was also reported. Bilateral salpingo-oophorectomy was performed before the cervical tumor was treated...
November 2018: International Journal of Gynecological Pathology
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