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International Journal of Gynecological Pathology

Andres Chiesa-Vottero
No abstract text is available yet for this article.
December 19, 2018: International Journal of Gynecological Pathology
W Glenn McCluggage, Hana Vosmikova, Jan Laco
Mesonephric-like adenocarcinomas are rare neoplasms occurring in the uterine corpus and ovary which bear a close morphologic resemblance to cervical mesonephric adenocarcinomas. They also have a similar immunophenotype and harbor similar molecular abnormalities to mesonephric adenocarcinomas and it is debated whether they are truly of mesonephric origin or represent Mullerian neoplasms closely mimicking mesonephric adenocarcinomas. We report an unusual case with bilateral ovarian serous borderline tumors and extraovarian low-grade serous carcinoma (invasive implants)...
December 19, 2018: International Journal of Gynecological Pathology
Chika R Nwachukwu, Jeremy P Harris, Alex Chin, Rie Von Eyben, Stephanie Giaretta, Jenny L Shaffer, Susan M Hiniker, Daniel S Kapp, Ann K Folkins, Elizabeth A Kidd
To evaluate the correlation between p16 expression and clinical outcomes in patients with primary vaginal cancer treated with definitive radiotherapy. P16 immunohistochemical was performed on 25 patient samples and recorded from pathology reports in 7 patients. P53 immunohistochemical was performed on 3 p16-negative samples. Baseline characteristics were compared using the Fisher exact test. Outcomes were compared using log-rank tests, and cox proportional hazards models. Survival and recurrence analysis was performed with the Kaplan-Meier method and cumulative incidence estimates...
December 3, 2018: International Journal of Gynecological Pathology
Qiongrong Chen, Manxiang Wang, Zhigao Xu, Mingwei Wang, Su Jin, Sufang Tian, Shuyuan Xiao
Muir-Torre syndrome is a rare subtype of Lynch syndrome characterized by coincidence of skin neoplasm and visceral malignancies. Here, we report a case of this rare disease, whose diagnosis of the syndrome was first suspected by the pathologist. This was a 60-yr-old woman who presented with an axillary skin nodule, which was diagnosed as basal cell carcinoma. Further inquiry revealed that she was hospitalized for evaluation of a recurrent vaginal stump endometrial carcinoma. Histologic workup and immunohistochemistry for mismatch repair proteins of both the skin and vaginal tumor suggested the possibility of Muir-Torre syndrome...
December 3, 2018: International Journal of Gynecological Pathology
Noriaki Iizuka, Yoshihiro Ikura, Yasunori Fukuoka, Takashi Shibata, Masashi Okamoto, Akio Kamiya, Tetsuya Oishi, Fumikazu Kotsuji, Yasuhiro Iwai
Primary ovarian lymphomas are rare, but can potentially evoke diagnostic problems. We present a case of ovarian lymphoma, in which an ambiguous intraoperative pathologic report led to overtreatment (unnecessary surgery). A 73-yr-old woman with fatigue and low-grade fever was diagnosed as having a left ovarian tumor by imaging modalities. Exploratory laparotomy was carried out to confirm the diagnosis. The frozen tissue sections of the ovarian tumor showed condensed proliferation of atypical round cells accompanied with a few small lymphocytes...
December 3, 2018: International Journal of Gynecological Pathology
Varsha I Shah, Gareth L Rowlands, Ian W Thompson, Vaiyapuri P Sumathi, W Glenn McCluggage
Angiosarcomas of the female genital tract are rare and primary angiosarcoma of the cervix is extremely rare with only one prior case report. We report a case of a primary cervical angiosarcoma in a 43-yr-old woman who presented with heavy vaginal bleeding. Cervical biopsy and subsequent radical hysterectomy showed a malignant vascular tumor which was composed of spindled and epithelioid cells and formed abortive vascular channels. Immunohistochemically, the tumor cells were diffusely positive for CD31, CD34, ERG, and cyclin D1 and focally positive for D2-40...
December 3, 2018: International Journal of Gynecological Pathology
Gulisa Turashvili, Daniel J Fix, Robert A Soslow, Kay J Park
Primary extrarenal Wilms tumor of the gynecologic tract is extremely rare with scattered case reports occurring in the ovary, uterine corpus and cervix. Only 9 cases of primary ovarian Wilms tumor have been reported to date. Here, we provide an extensive literature review and describe 2 patients with ovarian Wilms tumor: a 36-yr-old female (patient 1) and a 16-yr-old female (patient 2), both presenting with abdominal pain and suspected ovarian torsion. They were each found to have unilateral ovarian masses measuring >15 cm in size which were removed by unilateral salpingo-oophorectomy...
December 3, 2018: International Journal of Gynecological Pathology
Catalin Taraboanta, Heidi Britton, Anna Plotkin, Nazila Azordegan, Philip B Clement, C Blake Gilks
Outpatient endometrial biopsy can give false-negative results, with a 0.9% reported posttest probability for endometrial carcinoma (EC) after a negative result. Our objective was to determine if there has been any improvement in the performance characteristics of endometrial biopsy over the last 15 yr. All hysterectomy specimens with a diagnosis of EC or atypical hyperplasia (AH), reported between May 2011 and May 2015, were identified and cross-referenced for any negative endometrial sampling results during the 5 yr before hysterectomy...
December 3, 2018: International Journal of Gynecological Pathology
Randi Woodbeck, Linda E Kelemen, Martin Köbel
Primary mucinous carcinoma of the ovary is uncommon, and while numerous studies have focused on improving our ability to distinguish these tumors from gastrointestinal metastases, recent data suggest that up to one fifth are still misdiagnosed with a previously underrecognized culprit: endometrioid carcinoma. Using an index case of an ovarian endometrioid carcinoma with mucinous differentiation masquerading as a mucinous carcinoma, we sought to identify the most efficient biomarker combination that could distinguish these 2 histotypes...
November 21, 2018: International Journal of Gynecological Pathology
Jeffrey D Seidman, Johanna Savage, Jayashree Krishnan, Russell Vang, Robert J Kurman
Noninvasive ovarian low-grade serous tumors [atypical proliferative serous tumor (APST)/serous borderline tumor] appear to progress to invasive low-grade serous carcinoma (LGSC) at a low but regular rate. The underlying biology of this phenomenon is unknown. We studied 18 patients with 30 ovarian tumors (12 bilateral), including APST, noninvasive LGSC and invasive LGSC, who also had low-grade serous carcinomatosis. Tumors were evaluated for microinvasion (usual eosinophilic cell type), microinvasive carcinoma (<5 mm invasion of micropapillary nests), and overt carcinoma (≥5 mm invasion of micropapillary nests)...
November 21, 2018: International Journal of Gynecological Pathology
Steven Irwin, Afzal Karim, Pamela McHenry, Sonya Hutchinson, Keith Miller, Jackie Jamison, Joseph Houghton, W Glenn McCluggage
Epidermolytic acanthoma is a rare benign lesion that most often presents as a solitary or multiple small papular lesions on the trunk, face, limbs or external male genitalia. Only a small number of cases have been reported occurring on the vulva and clinically and histologically they may mimic and be misdiagnosed as viral warts. We report 2 cases of multiple epidermolytic acanthomas localized to the vulva. Molecular tests (in situ hybridization and polymerase chain reaction) showed no evidence of human papillomavirus infection and p16 staining was negative...
November 21, 2018: International Journal of Gynecological Pathology
Stephanie M McGregor, Larissa V Furtado, Anthony G Montag, Rebecca Brooks, Ricardo R Lastra
Epithelioid trophoblastic tumor is a malignancy derived from the chorionic laeve-type intermediate trophoblast with sufficient rarity that the vast majority of literature on the topic exists in the form of case reports and small series. Classically, it is regarded as a well-circumscribed tumor with an expansile growth pattern that occurs in reproductive-aged women, usually after a normal pregnancy. However, we recently encountered a case of epithelioid trophoblastic tumor with aggressive spread throughout the abdomen and pelvis in a 68-yr-old female presenting 30 yr after her last delivery...
November 21, 2018: International Journal of Gynecological Pathology
Rofieda Alwaqfi, Martin C Chang, Terence J Colgan
The use of p57 immunohistochemistry (IHC) can distinguish complete mole (CM) from partial mole (PM) and nonmolar abortus (NMA). Molecular genotyping (MG) is the gold standard method for the definitive diagnosis of PM and NMA. However, MG is expensive and not always available. Some data suggest Ki-67 IHC may be helpful in distinguishing NMAs from PMs and could be a substitute for MG. In this study, we examined the utility of p57 and Ki-67 IHC stains in the diagnosis of placental molar disease. The study cohort consisted of 60 cases of products of conception (20 CMs, 20 PMs, and 20 NMAs)...
November 1, 2018: International Journal of Gynecological Pathology
Sharon Song, Amy Ziober, Kumarasen Cooper
Cervicovaginal myofibroblastoma (CVM) is a rare benign mesenchymal tumor of the lower female genital tract that shows chromosomal loss of 13q14 (RB1 gene located in this region). The aim of this study was to investigate the utility of immunohistochemistry (IHC) for desmin, CD34, and Rb in diagnosing CVM. All cervical polyps diagnosed from July 2016 to July 2017 were retrospectively reviewed. Cases showing morphologic myofibroblastic differentiation were evaluated by IHC for desmin, CD34, and Rb. Desmin and CD34 staining was recorded as positive or negative...
October 31, 2018: International Journal of Gynecological Pathology
Giuseppe Angelico, Angela Santoro, Damiano Arciuolo, Michele Valente, Vittoria Carbone, Anna Fagotti, Giovanni Scambia, Gian Franco Zannoni
No abstract text is available yet for this article.
October 31, 2018: International Journal of Gynecological Pathology
Elena Lucas, Hao Chen, Kyle Molberg, Diego H Castrillon, Glorimar Rivera Colon, Long Li, Stacy Hinson, Joel Thibodeaux, Jayanthi Lea, David S Miller, Wenxin Zheng
Screening for Lynch syndrome (LS) is routinely performed in patients with endometrial carcinoma. Currently, no screening recommendations exist for LS in precancerous lesions. The study goal was to determine the incidence of abnormal protein expression in endometrioid intraepithelial neoplasia/atypical hyperplasia (EIN/AH). We analyzed mismatch repair (MMR) protein expression by immunohistochemistry in EIN/AH concurrent with MMR-deficient endometrial carcinomas, and in endometrial biopsy/curettage specimens with EIN/AH from an unselected group of patients...
October 31, 2018: International Journal of Gynecological Pathology
Somruetai Shuangshoti, Chinachote Teerapakpinyo
Adenomatous polyps of the vulva and vagina are extremely rare. We report a case of a 74-yr-old women with a tubulovillous adenoma occurring in the vagina, and a second one occurring later in the vulva. Tumor cells in both lesions were CK7, CK20, CDX-2, and showed intact mismatch-repair proteins. A G13D (c.38G>A, p.Gly13Asp) mutation in the KRAS gene was identified in both masses. As well, a novel frameshift truncating mutation (c.4320delA, p.Pro1441fsTer32) in the APC gene was detected only in the vaginal mass, ruling out the possibility that the vulvar mass was a local recurrence of the vaginal mass...
October 31, 2018: International Journal of Gynecological Pathology
Patrick Lebok, Rosemary E Zuna, Laura L Holman, Robert H Young
The case of a 36-yr-old woman with a pituitary adenoma who was found to have bilateral ovarian masses is reported. The right ovary was removed, measured 15 cm in maximum dimension, and contained multiple cysts which on microscopic examination had the typical morphology of follicle cysts. The left ovary was grossly similar intraoperatively. Subsequent excision of the pituitary adenoma was followed ∼3 mo later by a return to normal size of the left ovary. The case represents an example of multiple luteinized follicle cysts, analogous to the phenomenon seen occasionally in pregnancy, but with a different clinical background...
October 24, 2018: International Journal of Gynecological Pathology
Naveena Singh, Lynn Hirschowitz, Richard Zaino, Isabel Alvarado-Cabrero, Maire A Duggan, Rouba Ali-Fehmi, Elizabeth Euscher, Jonathan L Hecht, Lars-Christian Horn, Olga Ioffe, Xavier Matias-Guiu, W Glenn McCluggage, Yoshiki Mikami, Jaume Ordi, Vinita Parkash, M Ruhul Quddus, Charles M Quick, Annette Staebler, Charles Zaloudek, Marisa Nucci, Anais Malpica, Esther Oliva
Although endometrial carcinoma (EC) is generally considered to have a good prognosis, over 20% of women with EC die of their disease, with a projected increase in both incidence and mortality over the next few decades. The aim of accurate prognostication is to ensure that patients receive optimal treatment and are neither overtreated nor undertreated, thereby improving patient outcomes overall. Patients with EC can be categorized into prognostic risk groups based on clinicopathologic findings. Other than tumor type and grade, groupings and recommended management algorithms may take into account age, body mass index, stage, and presence of lymphovascular space invasion...
January 2019: International Journal of Gynecological Pathology
Colin J R Stewart, Christopher P Crum, W Glenn McCluggage, Kay J Park, Joanne K Rutgers, Esther Oliva, Anais Malpica, Vinita Parkash, Xavier Matias-Guiu, Brigitte M Ronnett
In most cases of suspected endometrial neoplasia tumor origin can be correctly assigned according to a combination of clinical, radiologic, and pathologic features, even when the latter are based upon the examination of relatively small biopsy samples. However there are well-recognized exceptions to this rule which continue to create diagnostic difficulty, and sometimes difficulties persist even after the detailed examination of resection specimens. Among the most common problems encountered in practice are the distinction of primary endometrial and primary endocervical adenocarcinomas, and the determination of tumor origin when there is synchronous, multifocal involvement of gynecologic tract sites, for example the endometrium and the ovary...
January 2019: International Journal of Gynecological Pathology
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