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Clinical Neuropathology

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https://www.readbyqxmd.com/read/28899479/olfactory-ensheathing-cell-tumor-a-case-presentation
#1
Michael H Schild, William T Harrison, Thomas J Cummings
No abstract text is available yet for this article.
September 7, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28899478/clinically-diagnosed-susac-syndrome-in-a-50-year-old
#2
Francesca M Brett, Seamus Looby, Conor Fearon, Peter Widdess-Walsh
No abstract text is available yet for this article.
September 7, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28853696/amelanotic-melanocytoma-of-the-sella-mimicking-pituitary-adenoma
#3
Boleslaw Lach, Kesava Reddy, Doron D Sommer, Anthony C Whitton, Reena Baweja
We describe a 50-year-old man with a well-demarcated intra- and extrasellar lesion and clinical signs of a non-functioning pituitary adenoma. Neuropathological examination revealed tumor composed of non-pigmented spindle cells arranged in tightly packed nests separated by delicate vascular septae. There was no significant cellular atypia or mitotic activity, and Ki67-positive nuclei were present in less than 1% of cells. The neoplastic cells were positive for S-100 and vimentin, and negative for numerous cellular markers including HMB45, anti-melanoma cocktail antibodies, and Masson melanin stain...
August 30, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28853695/paradoxical-results-obtained-with-ki67-labeling-and-phh3-mitosis-index-in-glial-tumors-a-literature-analysis
#4
İlhan Elmaci, Meric A Altinoz, Fatih Han Bolukbasi, Ozlem Yapicier, Aydin Sav
Precise tiered tumor grading is essential for predicting prognosis, selecting different treatment options and for follow-up of brain tumor patients. Ki67 labeling index (LI) is widely employed in assessing aggressiveness of glial brain tumors. However, Ki67 is subject to interlaboratory variability, and its antigen is expressed on all cell cycle phases except G0, which hinders its usage as a precise criterion for assessing cell proliferation. Indeed, there exist peculiar observations pertinent to increases of Ki67 index in glial tumors following radiotherapy or treatment with tyrosine kinase inhibitors...
August 30, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28766496/mixed-hemangioblastoma-and-ependymoma-collision-tumor-of-the-cerebellum
#5
Michael H Schild, Elizabeth P Doane, Allan H Friedman, Thomas J Cummings
No abstract text is available yet for this article.
August 2, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28737124/distribution-and-expression-of-brain-derived-neurotrophic-factor-nerve-growth-factor-and-neurotrophic-factor-3-in-refractory-epilepsy-associated-focal-cortical-dysplasia
#6
Feng Wang, Yuanxiang Lin, Dezhi Kang, Fuxiang Chen, Kun Lin, Xingfen Su
OBJECTIVE: To investigate the expression and distribution of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophic factor-3 (NT-3) in refractory epilepsy-associated type I focal cortical dysplasia (FCD I) and FCD IIA patients, and to explore their effects on pathogenesis of FCD I and FCD IIA. MATERIALS AND METHODS: 19 subjects who received surgery at the Department of Neurosurgery, First Affiliated Hospital, Fujian Medical University, China between June 2010 and May 2012, were enrolled in this study...
July 24, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28699883/familial-melanoma-astrocytoma-syndrome-synchronous-diffuse-astrocytoma-and-pleomorphic-xanthoastrocytoma-in-a-patient-with-germline-cdkn2a-b-deletion-and-a-significant-family-history
#7
Andrew K Chan, Seunggu J Han, Winward Choy, Daniah Beleford, Manish K Aghi, Mitchel S Berger, Joseph T Shieh, Andrew W Bollen, Arie Perry, Joanna J Phillips, Nicholas Butowski, David A Solomon
Familial melanoma-astrocytoma syndrome is a tumor predisposition syndrome caused by inactivating germline alteration of the CDKN2A tumor suppressor gene on chromosome 9p21. While some families with germline CDKN2A mutations are prone to development of just melanomas, other families develop both melanomas, astrocytomas, and occasionally other nervous-system neoplasms including peripheral nerve sheath tumors and meningiomas. The histologic spectrum of the astrocytomas that arise as part of this syndrome is not well described, nor are the additional genetic alterations that drive these astrocytomas apart from the germline CDKN2A inactivation...
July 12, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28816112/toxoplasmosis-of-the-pituitary-gland
#8
Nicholas F Prayson, Richard A Prayson
No abstract text is available yet for this article.
September 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28655380/clinical-neuropathology-image-4-2017-high-resolution-7-tesla-mri-of-postmortem-brain-specimens-improving-neuroimaging-neuropathology-correlations
#9
Mar Guasp-Verdaguer, Oriol Grau-Rivera, Alberto Prats-Galino, Núria Bargalló, Raquel Sánchez-Valle, Ellen Gelpi, Guadalupe Soria
No abstract text is available yet for this article.
July 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28332470/adult-onset-demyelinating-neuropathy-associated-with-fbln5-gene-mutation
#10
Si Cheng, He Lv, Wei Zhang, Zhaoxia Wang, Xin Shi, Wei Liang, Yun Yuan
Rare forms of autosomal-dominant Charcot-Marie-Tooth disease (AD-CMT) may be associated with mutations in Fibulin-5 (FBLN5) as AD-CMT is genetically heterogeneous. Here, we report the first pathological study of an Asian family. The proband was a 46-year-old man with slowly progressive distal numbness and weakness for 12 years. He had a history of diabetes mellitus for 12 years. His mother was 81 years old and had mild polyneuropathy. His 16-year-old daughter was asymptomatic. The nerve conduction velocities (NCVs) and compound muscular action potential (CMAP) amplitudes were moderately to severely reduced in the proband, and moderately reduced in his daughter and mother...
July 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28502321/cytomegalovirus-in-the-human-dentate-gyrus-and-its-impact-on-neural-progenitor-cells-report-of-two-cases
#11
Ju-Yoon Yoon, Brett Danielson, Derek Mathis, Jason Karamchandani, David G Munoz
Congenital cytomegalovirus (CMV) infection in the 2nd and 3rd trimester results in catastrophic CNS abnormalities. This susceptibility is thought to result from the high proportion of neural stem cells in the developing brain. In immunocompromised adults, CNS infection by CMV preferentially affects ependymal surfaces, from where it expands to involve the parenchyma. Experimental models of murine CMV infection demonstrate viral tropism for the dentate gyrus (DG) and subventricular zone, the areas in which adult neurogenesis occurs...
May 15, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28502320/atypical-teratoid-rhabdoid-tumor-arising-in-a-pleomorphic-xanthoastrocytoma-a-rare-entity
#12
Meral Uner, Arzu Saglam, Bilge Can Meydan, Kerim Aslan, Figen Soylemezoglu
Atypical teratoid rhabdoid tumor (AT/RT) is a rare and aggressive tumor usually occurring at younger ages. Pleomorphic xanthoastrocytomas (PXA) on the other hand are quiescent tumors with benign behavior. AT/RTs arising in the setting of PXA are exceptional. We present the case of a 23-year-old female patient, the fourth in the literature, speculated as having AT/RT arising within a PXA, as demonstrated by the presence of INI1 mutation. The patient presented with a short history of headache, which increased over time, and emerging seizures...
May 15, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28502319/an-unusual-case-of-a-young-patient-with-whipple-s-disease-involving-the-central-nervous-system
#13
Margaret E Flanagan, Nicole Andeen, Joshua Lieberman, Joseph Freeburg, John R Williams, Daniel R Hoogestraat, Andrew Bryan, Daniel E Sabath
No abstract text is available yet for this article.
May 15, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28436370/clinical-neuropathology-image-3-2017-cns-involvement-in-systemic-amyloidosis-restricted-to-the-choroid-plexus
#14
Ellen Gelpi, Martin Susani, Robert Wiebringhaus, Andreas Aschauer, Andreas Kammerlander, Mirjam I Lutz, Johannes A Hainfellner
No abstract text is available yet for this article.
May 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28139968/disseminated-strongyloidiasis-and-concomitant-aspergillus-infection-with-central-nervous-system-involvement
#15
Hannah Wang, Richard A Prayson
No abstract text is available yet for this article.
May 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28128725/unusual-skull-tumors-with-psammomatoid-bodies-a-diagnostic-challenge
#16
Timothy E Richardson, Maria-Magdalena Georgescu, Payal Kapur, Helena Hwang, Samuel L Barnett, Jack M Raisanen, Chunyu Cai, Kimmo J Hatanpaa
AIM: We describe a series of three diagnostically challenging, histologically similar fibro-osseous skull masses. METHODS: The cases were identified in our archives among 50,000 neuropathology specimens. A comprehensive review of the histological, immunohistochemical, ultrastructural, and imaging features as well as the clinical outcome was performed. RESULTS: The routine histology was similar in all 3 cases and showed spindle cell proliferations with frequent calcospheres or psammomatoid bodies...
May 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/27841144/cystic-endosalpingiosis-of-lumbar-nerve-root-a-unique-presentation
#17
Valeria Barresi, Debra Barns, Raymond Grundmeyer Rd, Fausto J Rodriguez
AIMS: Endosalpingiosis is a non-neoplastic condition characterized by the presence of ciliated epithelium, resembling tubal epithelium, in heterotopic locations. Its presence has been reported in several anatomical sites in the pelvic, abdominal, and thoracic cavities. Herein we report a rare case of endosalpingiosis presenting as a cystic mass with spinal nerve root attachment. METHODS: Clinical history was obtained through review of medical records. The surgical specimen was formalin fixed and paraffin embedded for histological evaluation with hematoxylin and eosin stain and immunohistochemistry...
May 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28438258/intraneural-glomus-tumor-of-uncertain-malignant-potential-and-with-braf-mutation-in-the-median-nerve-an-unusual-case
#18
Lars B Dahlin, Peter Scherman, Jack Besjakov, Eva Lindberg, David A Solomon, Andrew E Horvai, Arie Perry
A glomus tumor of uncertain malignant potential is defined as a glomus tumor with some, but not all, criteria for malignancy and without a known metastasis. Here, we present a rare example presenting in the median nerve in a 40-year-old woman with a long history of severely impaired left median nerve function. A large panel of immunohistochemical stains excluded other diagnoses, and the designation of a "uncertain malignant potential" was based on the high proliferative activity, the tumor size and location, and the lack of WHO malignancy criteria such as marked nuclear atypia, necrosis, or atypical mitoses...
April 25, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28427499/coexistent-venous-angioma-and-focal-cortical-dysplasia
#19
Richard A Prayson, Elizabeth E O'Toole
No abstract text is available yet for this article.
April 21, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28406082/intraventricular-ganglioglioma-with-extensive-hemorrhage
#20
William Warnica, John P Provias
Gangliogliomas represent a rare form of neuroepithelial tumor (up to 1.3% of brain tumors [1]), which even more rarely present with hemorrhage or localize intraventricularly. To date, only two cases of ganglioglioma with both of these features have been reported. Our patient is a 23-year-old woman who presented with signs and symptoms of increased intracranial pressure (ICPI), with a post-subtotal resection diagnosis of WHO Grade I ganglioglioma localizing bilaterally to the lateral ventricles. One year following the operation, the tumor showed radiologic evidence of interval hemorrhage, which was verified histopathologically following a second subtotal resection...
April 13, 2017: Clinical Neuropathology
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