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Clinical Neuropathology

Nila Volpi, Federica Ginanneschi, Alfonso Cerase, Salvatore Francesco Carbone, Margherita Aglianò, Paola Lorenzoni, Matteo Bellini, Sabina Bartalini, Giovanni Di Pietro, Alessandro Rossi
No abstract text is available yet for this article.
February 16, 2018: Clinical Neuropathology
Julia Lang, Thomas Czech, Irene Slavc, Dominik Reisinger, Sophie Bartsch, Johannes A Hainfellner, Christine Haberler, Ellen Gelpi
No abstract text is available yet for this article.
February 13, 2018: Clinical Neuropathology
Hugh Kearney, Jane Cryan, Alan Beausung, Seamus Looby, Francesca M Brett
The aim of this study is to identify, in our center, all cases of foreign-body reactions to hemostatic agents or other prostheses resulting in a radiological suspicion of tumor recurrence. We interrogated our internal database to identify all such cases and systematically evaluated the MRI brain scans of patients: (i) at the time of initial tumor diagnosis, (ii) postoperatively, (iii) and at the time of suspected tumor recurrence. In addition, we reviewed each patient's operative notes and reviewed the histology of all cases following a second surgical intervention...
February 9, 2018: Clinical Neuropathology
Bette K Kleinschmidt-DeMasters, Jean M Mulcahy Levy
BACKGROUND: H3 K27M mutation was originally described in pediatric diffuse intrinsic pontine gliomas (DIPGs), but has been recently recognized to occur also in adult midline diffuse gliomas, as well as midline tumors with other morphologies, including gangliogliomas (GGs), anaplastic GGs, pilocytic astrocytomas (PAs), and posterior fossa ependymomas. In a few patients with H3 K27M-mutant tumors with these alternate morphologies, longer survival has been reported, making grading difficult for the neuropathologist...
February 2, 2018: Clinical Neuropathology
Hugh Kearney, Jane B Cryan, Seamus Looby, Francesca M Brett, Michael A Farrell, Patrick G Buckley
Intracranial collision tumors are composed of two histologically distinct but merging components, and are rare. Their genetic profile has rarely been described. Comparative genome hybridization of a combined meningioma and oligodendroglioma demonstrated deletion of chromosome 22q and of 19q in both tumors. Somatic deletion of chromosome 22q and 19q is associated with development of an intracranial collision tumor.
January 19, 2018: Clinical Neuropathology
Masayuki Shintaku, Daita Kaneda, Kiyomitsu Oyanagi
The patient was an 81-year-old woman diagnosed with atypical motor neuron disease who died after a long clinical course (7.5 years without mechanical assistance of ventilation) characterized by lower motor neuron signs and symptoms. Upper motor neuron signs and cognitive impairment were not apparent. Autopsy demonstrated severe neuronal loss in the anterior horn of the spinal cord, and some of the remaining neurons showed enlargement of Nissl substance and apparent thickening of the nuclear envelopes. No Bunina bodies, skein-like inclusions, or structures immunoreactive for phosphorylated transactivation response DNA-binding protein 43 were found...
January 19, 2018: Clinical Neuropathology
Yoon Jin Cha, Junjeong Choi, Se Hoon Kim
AIM: To evaluate the overlapping and distinguishing cytologic features of primary central nervous system lymphoma (PCNSL), diffuse large B-cell lymphoma, and glioblastoma (GM) in frozen sections and squash smear slides. MATERIALS AND METHODS: Intraoperative frozen sections and squash smear slides from PCNSL (N = 63) and GM (N = 122) patients diagnosed from 2005 to 2015 were retrieved from pathology records. Overlapping and distinguishing histologic features were examined and statistically analyzed...
January 16, 2018: Clinical Neuropathology
Audrey Benyamine, Clemence Delteil, Nicolas Macagno, Pauline Belenotti, Bertrand Dussol, Nadine Girard, Pierre-Jean Weiller, Brigitte Granel, Laurent Daniel
No abstract text is available yet for this article.
January 10, 2018: Clinical Neuropathology
Rebeca Alvarez, Michael Schild, Thomas J Cummings
No abstract text is available yet for this article.
January 10, 2018: Clinical Neuropathology
Thomas Roetzer, Melitta Kitzwoegerer, Gertraud Heinz, Stefan Oberndorfer, Franz Marhold, Johannes A Hainfellner, Adelheid Woehrer
No abstract text is available yet for this article.
January 10, 2018: Clinical Neuropathology
Sumit Das, Lee-Cyn Ang, David Ramsay
Cavernous hemangioma in the sellar region is quite rare with only a handful of cases being reported in the English literature. Its clinical manifestations and imaging characteristics can mimic those of a pituitary adenoma. We report two cases of recurrent sellar lesions, both of which were clinically suspected of being pituitary adenomas but histologically confirmed as cavernous hemangiomas. The first case is of a 67-year-old female whose initial resection was diagnosed as "venous angioma". Neuroimaging performed 27 years later demonstrated significant growth of the lesion involving the right cavernous sinus and encasing the right internal carotid artery...
March 2018: Clinical Neuropathology
Brigid E Prayson, Richard A Prayson
No abstract text is available yet for this article.
January 2018: Clinical Neuropathology
Hiroaki Takeuchi, Hiroyuki Neishi, Yoshifumi Higashino, Ryuhei Kitai, Ken-Ichiro Kikuta, Yoshiyuki Imamura
Pilocytic astrocytoma (PA), featuring activation of the mitogen-activated protein kinase (MAPK) pathway, is the most common tumor of the pediatric central nervous system. However, it remains unknown whether MAPK activation is present in the reactive gliosis of non-neoplastic lesions. Therefore, we investigated the expression of MAPK in reactive gliosis associated with cavernous angiomas. Immunohistochemical expression and the extent of BRAF, ERK, p38, and JNK were investigated in 10 patients with gliosis surrounding cavernous angiomas (GS group) and 10 patients with PA (PA group)...
January 2018: Clinical Neuropathology
Sébastien Lepreux, Johannes A Hainfellner, Anne Vital
A muscle biopsy is currently requested to assess the diagnosis of an idiopathic inflammatory myopathy overlapping with a systemic disease. During the past few years, the classification of inflammatory myopathy subtypes has been revisited progressively on the basis of correlations between clinical phenotypes, autoantibodies and histological data. Several syndromic entities are now more clearly defined, and the aim of the present review is to clarify the contribution of muscle biopsy in a setting of idiopathic inflammatory myopathies overlapping with systemic diseases...
January 2018: Clinical Neuropathology
Luis Ruano, Mariana Branco, Raquel Samões, Ricardo Taipa, Manuel Melo Pires
The etiology of intracerebral hemorrhage (ICH) is frequently undetermined. We aimed to assess the impact of the neuropathological study on the etiologic diagnosis of ICH. Patients with ICH admitted to a tertiary hospital in the last 14 years were identified, and histological samples of surgically-drained ICH were retrieved. Blinded from neuropathological results, a clinical etiology was hypothesized. Pathological samples were reviewed, and immunohistochemistry study for β-amyloid was performed in all the cases where structural abnormalities were not identified...
January 2018: Clinical Neuropathology
Sara Mariotto, Marina Bentivoglio, Tiziana Cotrufo, Antonella Berzero, Salvatore Monaco, Paolo Mazzarello, Sergio Ferrari
No abstract text is available yet for this article.
December 18, 2017: Clinical Neuropathology
Johannes A Hainfellner
No abstract text is available yet for this article.
November 2017: Clinical Neuropathology
Kimberly J Johnson, Judith Schwartzbaum, Carol Kruchko, Michael E Scheurer, Ching C Lau, Adelheid Woehrer, Johannes A Hainfellner, Joseph Wiemels
The Brain Tumor Epidemiology Consortium (BTEC) is an international consortium that aims to advance the development of multicenter and interdisciplinary collaborations that focus on research related to the etiology, outcomes, and prevention of brain tumors. The 18<sup>th</sup> annual BTEC meeting was held in Banff, AB, Canada, on June 27 - 29, 2017. The meeting focused on the intersection between epidemiology and precision medicine, that is, the use of molecular indicators of risk, early disease and prognosis or precision epidemiology...
November 2017: Clinical Neuropathology
Drew Pratt, Nina Afsar, Michael Allgauer, Patricia Fetsch, Maryknoll Palisoc, Stefania Pittaluga, Martha Quezado
TTF-1 is widely used as a marker in routine surgical pathology in the work-up of malignancy. Aberrant expression of TTF-1 in extrapulmonary and extrathyroidal malignancies is a frequently reported phenomenon. In addition to the recently characterized pituicyte-derived tumors of the sella, immunoreactivity has been reported in diffuse gliomas with the SPT24 clone. Here, we sought to evaluate TTF-1 expression with three commercially available clones in a large series of gliomas. Expression was compared across the newly defined diagnostic entities in the 2016 WHO Classification of CNS Tumors...
November 2017: Clinical Neuropathology
Michael H Schild, William T Harrison, Thomas J Cummings
No abstract text is available yet for this article.
November 2017: Clinical Neuropathology
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