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Clinical Neuropathology

Stefan Reers, David Krug, Walter Stummer, Martin Hasselblatt
No abstract text is available yet for this article.
November 30, 2016: Clinical Neuropathology
Benoit Dumont, Fabien Forest, Pierre Dal Col, Georgia Karpathiou, Jean-Louis Stephan, François Vassal, Michel Péoc'h
No abstract text is available yet for this article.
November 14, 2016: Clinical Neuropathology
Fatemeh Derakhshan, Catalin Taraboanta, Stephen Yip
A leiomyoma is a low-grade tumors originating from smooth-muscle cells. Primary intracranial leiomyoma is extremely rare and usually reported in immunocompromised patients. We present a case of primary intracranial leiomyoma in a 44-year-old male with a chief complaint of headache. The pathological analysis and relevant literature has been discussed.
November 14, 2016: Clinical Neuropathology
Valeria Barresi, Debra Barns, Raymond Grundmeyer, Fausto J Rodriguez
AIMS: Endosalpingiosis is a non-neoplastic condition characterized by the presence of ciliated epithelium, resembling tubal epithelium, in heterotopic locations. Its presence has been reported in several anatomical sites in the pelvic, abdominal, and thoracic cavities. Herein we report a rare case of endosalpingiosis presenting as a cystic mass with spinal nerve root attachment. METHODS: Clinical history was obtained through review of medical records. The surgical specimen was formalin fixed and paraffin embedded for histological evaluation with hematoxylin and eosin stain and immunohistochemistry...
November 14, 2016: Clinical Neuropathology
Mousa Mobarki, Fabien Forest, François Vassal, Georgia Karpathiou, Michel Péoc'h
No abstract text is available yet for this article.
October 26, 2016: Clinical Neuropathology
Jinglan Liu, Matthew P Keisling, Ayman Samkari, Gregory Halligan, Judy M Pascasio, Christos D Katsetos
Central nervous system (CNS) tumors exhibiting dual features of malignant glioma (MG) and primitive neuroectodermal tumor (PNET) are rare and diagnostically challenging. Previous studies have shown that MG-PNET carry MYCN or MYC gene amplifications within the PNET component concomitant with glioma-associated alterations, most commonly 10q loss, in both components [9]. Here we confirm and extend the profile of molecular genetic findings in a MG-PNET involving the left frontal lobe of a 12-year-old male. Histologically, the PNET-like component showed morphological features akin to anaplastic medulloblastoma highlighted by widespread immunoreactivity for βIII-tubulin (TUBB3) and nonphosphorylated neurofilament protein, and to a lesser degree, Neu-N, synaptophysin, and CD99, whereas the gliomatous component was demarcated by glial fibrillary acidic protein (GFAP) labeling...
October 26, 2016: Clinical Neuropathology
Neha Goel, Saritha Aryan, Laxminadh Sivaraju, Nandita Ghosal
No abstract text is available yet for this article.
October 14, 2016: Clinical Neuropathology
Hirotaka Sekiguchi, Masatsugu Moriwaki, Shuji Iritani, Chikako Habuchi, Youta Torii, Kentaro Umeda, Hiroshige Fujishiro, Mari Yoshida, Kiyoshi Fujita
We herein report the case of a 75-year-old male who had shown many psychiatric symptoms, but whose autopsy disclosed the presence of dementia with Lewy bodies (DLB). When he was 70 years old, the patient had presented with stereotyped behavior, dietary changes, and a decline in social interpersonal conduct in clinical settings, and it was thought that these symptoms were consistent with a behavioral variant of frontotemporal dementia (bvFTD), and he lacked the core features of DLB. Nevertheless, this case was pathologically defined as the limbic type of DLB after he died at the age of 75 years...
October 14, 2016: Clinical Neuropathology
Aditya Shivane, Mark E F Smith, David Lewis, Titus Berei
No abstract text is available yet for this article.
October 10, 2016: Clinical Neuropathology
Yuqiao Xu, Lijuan Ye, Yingmei Wang, Wanling Ma, Qing Li
No abstract text is available yet for this article.
October 10, 2016: Clinical Neuropathology
Yunqing Chen, Junjun Zheng, Shuyun Chen, Min Zhu, Daojun Hong
AIMS: To investigate the underlying mechanisms of how the defects of desmin cause mitochondrial abnormalities in desminopathy. MATERIAL AND METHODS: Primary myoblasts were isolated from muscle biopsy of a desminopathy patient with mitochondrial abnormalities. Two-dimensional gel electrophoresis analyses of mitochondrial proteins were performed in mitochondria isolated from myoblasts. Immunostaining, immunoblot, and mitochondrial function tests were carried out to confirm the proteomic results...
October 10, 2016: Clinical Neuropathology
Sahejmeet S Guraya, Richard A Prayson
Clear cell sarcoma (CCS) of the gastrointestinal tract presents a diagnostic challenge to the pathologist due to its morphological and immunohistochemical similarity to melanoma. It usually metastasizes to regional lymph nodes, liver, and lungs. Herein, we report the first known metastasis of a gastrointestinal CCS to the central nervous system. Cytogenetic testing showed the t(12,22) translocation corresponding to the presence of the EWS/ATF1 hybrid consistent with CCS. The literature that compares melanoma to CCS is reviewed in the context of this rare presentation to differentiate between the two diseases...
October 10, 2016: Clinical Neuropathology
Satoshi Yokoi, Keizo Yasui, Yasuhiro Hasegawa, Kazuki Niwa, Yoshinori Noguchi, Toyonori Tsuzuki, Maya Mimuro, Jun Sone, Hirohisa Watanabe, Masahisa Katsuno, Mari Yoshida, Gen Sobue
AIMS: Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder with eosinophilic intranuclear inclusion bodies. The variable symptoms of NIID increase the difficulty in an antemortem diagnosis. NIID shows leukoencephalopathy on brain magnetic resonance imaging MRI, but the significance of the radiological findings have not been clarified. METHODS: We examined an autopsied case of NIID with subcortical linear hyperintensities on diffusion weighted imaging (DWI) and leukoencephalopathy on fluid attenuation inversion recovery (FLAIR) imaging...
October 10, 2016: Clinical Neuropathology
Alaa Samkari, Faris Alzahrani, Abeer Almehdar, Hussein Algahtani
Desmoplastic infantile astrocytoma (DIA) is a rare, supratentorial, dural-based, large cystic tumor that usually arises in the first 24 months of life. However, non-infantile cases were also reported in the literature. Desmoplastic infantile astrocytoma and desmoplastic infantile ganglioglioma (DIG) are both classified as grade I astrocytoma by the World Health Organization (WHO). Grossly, DIA/DIG are large tumors composed of solid and cystic portions. Although large in nature, they are slow-growing tumors, with good prognosis after complete surgical removal, and rarely require a chemotherapy or radiotherapy...
September 26, 2016: Clinical Neuropathology
Debajyoti Chatterjee, Kirti Gupta, Navneet Singla, Ankur Kapoor
While giant cell tumor is commonly a tumor of long bones, involvement of sphenoid bone is very rare. Clinically and radiologically, it mimics other neoplasms of this site. Endochondral ossification of this bone during development explains its curious preferential involvement in comparison to the rest of the skull bones. We describe an example of such a tumor arising in the sphenoid bone in a young woman and discuss the differential diagnosis. Recognizing its characteristic features is important for correct interpretation...
September 19, 2016: Clinical Neuropathology
Torsten Pietsch, Christine Haberler
The revised WHO classification of tumors of the CNS 2016 has introduced the concept of the integrated diagnosis. The definition of medulloblastoma entities now requires a combination of the traditional histological information with additional molecular/genetic features. For definition of the histopathological component of the medulloblastoma diagnosis, the tumors should be assigned to one of the four entities classic, desmoplastic/nodular (DNMB), extensive nodular (MBEN), or large cell/anaplastic (LC/A) medulloblastoma...
November 2016: Clinical Neuropathology
Francesca Brett, Alan Beausang, William Tormey, Michael Curtis
No abstract text is available yet for this article.
November 2016: Clinical Neuropathology
Kimberly J Johnson, Johannes A Hainfellner, Ching C Lau, Michael E Scheurer, Adelheid Woehrer, Joseph Wiemels
The Brain Tumor Epidemiology Consortium (BTEC) is an international consortium that aims to advance development of multicenter and interdisciplinary collaborations that focus on research related to the etiology, outcomes, and prevention of brain tumors. The 17th annual BTEC meeting was held in Barcelona, Spain on June 21 - 23, 2016. The meeting focused on immune and viral factors that influence brain tumor development. Fundamentals of innate and adaptive immunity were reviewed, the role of immune checkpoint inhibitors in primary and secondary brain tumors was addressed, vaccination strategies for glioma treatment were presented, and the potential contribution of immune dysfunction and viruses tropic for glial cells in gliomagenesis was discussed...
September 2016: Clinical Neuropathology
Ellen Gelpi, Romana Höftberger, Tanja Würger, Johannes Kerschbaumer, Christian F Freyschlag, Tanja Djurdjevic, Johannes A Hainfellner
*Both authors contributed equally.
September 2016: Clinical Neuropathology
Anna Maria Buccoliero, Chiara Caporalini, Flavio Giordano, Federico Mussa, Mirko Scagnet, Selene Moscardi, Gianna Baroni, Lorenzo Genitori, Gian Luigi Taddei
Subependymal giant-cell astrocytoma (SEGA) is a rare tumor associated with tuberous sclerosis complex (TSC). TSC mainly involves the central nervous system (CNS) where SEGA, subependymal nodules, and cortical tubers may be present. First studies suggested the astrocytic nature of SEGA while successive studies demonstrated the mixed glio-neuronal nature. There are similarities between TSC-associated CNS lesions and type IIb focal cortical dysplasia (FCD). In all these pathologies, mammalian target of rapamycin (mTOR) pathway activation has been demonstrated...
September 2016: Clinical Neuropathology
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