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Clinical Neuropathology

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https://www.readbyqxmd.com/read/28102813/intramedullary-amputation-neuroma-a-case-report-and-review-of-the-literature
#1
Laura Stone McGuire, Mandana Behbahini, Sumit Das, David Loeffler, Peter Burger, Herbert Engelhard, Tibor Valyi-Nagy, Ankit Mehta
BACKGROUND AND IMPORTANCE: Amputation neuromas consist of non-neoplastic collections of myelinated axons and Schwann cells and typically arise in injured peripheral nerves. Rarely, however, neuromas occur within the spinal cord. Intramedullary amputation neuromas have been described both with and without a history of trauma within the peripheral nervous system. We report a rare case of an isolated intramedullary spinal cord amputation neuroma. CLINICAL PRESENTATION: This 43-year-old man presented with progressive and severe gait deterioration for ~ 7 years...
January 19, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28025960/metastatic-spread-of-systemic-neoplasms-to-central-nervous-system-tumors-review-of-the-literature-and-case-presentation-of-esophageal-carcinoma-metastatic-to-meningioma
#2
Bertram Richter, Lakshmi Harinath, Cunfeng Pu, Kristen Stabingas
Metastatic spread of a systemic neoplasm to a central nervous system malignancy is a rare but well-documented phenomenon. Over 100 case reports of tumor-to-tumor spread involving the central nervous system have been described since the first report in 1930. Overwhelmingly, intracranial meningioma represents the most common recipient tumor, while breast and lung are the first and second most common donor malignancies, respectively. The propensity for meningiomas to harbor metastatic lesions has been attributed to cell-to-cell adhesion molecules, favorable metabolic environment as well as hormonal and mechanical factors...
December 27, 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/27936528/infratentorial-ganglioglioma-mimicking-pilocytic-astrocytoma
#3
Kirti Gupta, Madhivanan Karthigeyan, Pravin Salunke
Majority of tumors arising in posterior fossa in children are pilocytic astrocytoma. However, a small subset of these have a neuronal component that may either be admixed throughout with the glial component or may be segregated to one or two regions within the glial element. Interestingly, the radiological features of this subgroup are also distinctive, showing midline location, frequent cyst formation, hemorrhage, and circumscribed nature. Taken together, both radiological and pathological features can fairly predict the subgroup categorization within infratentorial gangliogliomas (GG), as has been recently elucidated...
December 12, 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/27900936/malignant-progression-of-a-histone-h3-3-k27m-mutated-spinal-pilocytic-astrocytoma-in-an-adult
#4
Stefan Reers, David Krug, Walter Stummer, Martin Hasselblatt
No abstract text is available yet for this article.
November 30, 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/27841146/pd1-and-pd-l1-in-ependymoma-might-not-be-therapeutic-targets
#5
Benoit Dumont, Fabien Forest, Pierre Dal Col, Georgia Karpathiou, Jean-Louis Stephan, François Vassal, Michel Péoc'h
No abstract text is available yet for this article.
November 14, 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/27841144/cystic-endosalpingiosis-of-lumbar-nerve-root-a-unique-presentation
#6
Valeria Barresi, Debra Barns, Raymond Grundmeyer, Fausto J Rodriguez
AIMS: Endosalpingiosis is a non-neoplastic condition characterized by the presence of ciliated epithelium, resembling tubal epithelium, in heterotopic locations. Its presence has been reported in several anatomical sites in the pelvic, abdominal, and thoracic cavities. Herein we report a rare case of endosalpingiosis presenting as a cystic mass with spinal nerve root attachment. METHODS: Clinical history was obtained through review of medical records. The surgical specimen was formalin fixed and paraffin embedded for histological evaluation with hematoxylin and eosin stain and immunohistochemistry...
November 14, 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/27781425/spinal-t-cell-rich-b-cell-lymphoma
#7
Mousa Mobarki, Fabien Forest, François Vassal, Georgia Karpathiou, Michel Péoc'h
No abstract text is available yet for this article.
October 26, 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/27966428/clinical-neuropathology-image-1-2017-incidental-schwannoma-of-the-posterior-root
#8
Ellen Gelpi, Mikel Vicente-Pascual
No abstract text is available yet for this article.
January 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/27966427/patterns-of-diagnostic-marker-assessment-in-adult-diffuse-glioma-a-survey-of-the-european-confederation-of-neuropathological-societies-euro-cns
#9
Adelheid Woehrer, Bjarne W Kristensen, Anne Vital, Johannes A Hainfellner
The 2016 update of the WHO classification has introduced an integrated diagnostic approach that incorporates both tumor morphology and molecular information. This conceptual change has far-reaching implications, especially for neuropathologists who are in the forefront of translating molecular markers to routine diagnostic use. Adult diffuse glioma is a prototypic example for a group of tumors that underwent substantial regrouping, and it represents a major workload for surgical neuropathologists. Hence, we conducted a survey among members of the European Confederation of Neuropathological Societies (Euro-CNS) in order to assess 1) the extent to which molecular markers have already been incorporated in glioma diagnoses, 2) which molecular techniques are in daily use, and 3) to set a baseline for future surveys in this field...
January 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/27737532/an-autopsy-case-of-dementia-with-lewy-bodies-clinically-diagnosed-to-have-a-behavioral-variant-of-frontotemporal-dementia
#10
Hirotaka Sekiguchi, Masatsugu Moriwaki, Shuji Iritani, Chikako Habuchi, Youta Torii, Kentaro Umeda, Hiroshige Fujishiro, Mari Yoshida, Kiyoshi Fujita
We herein report the case of a 75-year-old male who had shown many psychiatric symptoms, but whose autopsy disclosed the presence of dementia with Lewy bodies (DLB). When he was 70 years old, the patient had presented with stereotyped behavior, dietary changes, and a decline in social interpersonal conduct in clinical settings, and it was thought that these symptoms were consistent with a behavioral variant of frontotemporal dementia (bvFTD), and he lacked the core features of DLB. Nevertheless, this case was pathologically defined as the limbic type of DLB after he died at the age of 75 years...
January 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/27719747/mitochondrial-proteomics-reveal-potential-targets-involved-in-mitochondrial-abnormalities-of-desminopathy
#11
Yunqing Chen, Junjun Zheng, Shuyun Chen, Min Zhu, Daojun Hong
AIMS: To investigate the underlying mechanisms of how the defects of desmin cause mitochondrial abnormalities in desminopathy. MATERIAL AND METHODS: Primary myoblasts were isolated from muscle biopsy of a desminopathy patient with mitochondrial abnormalities. Two-dimensional gel electrophoresis analyses of mitochondrial proteins were performed in mitochondria isolated from myoblasts. Immunostaining, immunoblot, and mitochondrial function tests were carried out to confirm the proteomic results...
January 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/27719746/brain-metastasis-from-gastrointestinal-clear-cell-sarcoma
#12
Sahejmeet S Guraya, Richard A Prayson
Clear cell sarcoma (CCS) of the gastrointestinal tract presents a diagnostic challenge to the pathologist due to its morphological and immunohistochemical similarity to melanoma. It usually metastasizes to regional lymph nodes, liver, and lungs. Herein, we report the first known metastasis of a gastrointestinal CCS to the central nervous system. Cytogenetic testing showed the t(12,22) translocation corresponding to the presence of the EWS/ATF1 hybrid consistent with CCS. The literature that compares melanoma to CCS is reviewed in the context of this rare presentation to differentiate between the two diseases...
January 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/27668845/desmoplastic-infantile-astrocytoma-and-ganglioglioma-case-report-and-review-of-the-literature
#13
Alaa Samkari, Faris Alzahrani, Abeer Almehdar, Hussein Algahtani
Desmoplastic infantile astrocytoma (DIA) is a rare, supratentorial, dural-based, large cystic tumor that usually arises in the first 24 months of life. However, non-infantile cases were also reported in the literature. Desmoplastic infantile astrocytoma and desmoplastic infantile ganglioglioma (DIG) are both classified as grade I astrocytoma by the World Health Organization (WHO). Grossly, DIA/DIG are large tumors composed of solid and cystic portions. Although large in nature, they are slow-growing tumors, with good prognosis after complete surgical removal, and rarely require a chemotherapy or radiotherapy...
January 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/27781424/update-on-the-integrated-histopathological-and-genetic-classification-of-medulloblastoma-a-practical-diagnostic-guideline
#14
Torsten Pietsch, Christine Haberler
The revised WHO classification of tumors of the CNS 2016 has introduced the concept of the integrated diagnosis. The definition of medulloblastoma entities now requires a combination of the traditional histological information with additional molecular/genetic features. For definition of the histopathological component of the medulloblastoma diagnosis, the tumors should be assigned to one of the four entities classic, desmoplastic/nodular (DNMB), extensive nodular (MBEN), or large cell/anaplastic (LC/A) medulloblastoma...
November 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/27781423/malignant-glioma-with-primitive-neuroectodermal-tumor-like-component-mg-pnet-novel-microarray-findings-in-a-pediatric-patient
#15
Jinglan Liu, Matthew P Keisling, Ayman Samkari, Gregory Halligan, Judy M Pascasio, Christos D Katsetos
Central nervous system (CNS) tumors exhibiting dual features of malignant glioma (MG) and primitive neuroectodermal tumor (PNET) are rare and diagnostically challenging. Previous studies have shown that MG-PNET carry MYCN or MYC gene amplifications within the PNET component concomitant with glioma-associated alterations, most commonly 10q loss, in both components [9]. Here we confirm and extend the profile of molecular genetic findings in a MG-PNET involving the left frontal lobe of a 12-year-old male. Histologically, the PNET-like component showed morphological features akin to anaplastic medulloblastoma highlighted by widespread immunoreactivity for βIII-tubulin (TUBB3) and nonphosphorylated neurofilament protein, and to a lesser degree, Neu-N, synaptophysin, and CD99, whereas the gliomatous component was demarcated by glial fibrillary acidic protein (GFAP) labeling...
November 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/27719749/a-rare-case-of-primary-intracerebral-hodgkin-lymphoma
#16
Aditya Shivane, Mark E F Smith, David Lewis, Titus Berei
No abstract text is available yet for this article.
November 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/27719748/astrocytoma-with-extensive-infiltration-of-virchow-robin-spaces
#17
Yuqiao Xu, Lijuan Ye, Yingmei Wang, Wanling Ma, Qing Li
No abstract text is available yet for this article.
November 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/27719745/pathological-background-of-subcortical-hyperintensities-on-diffusion-weighted-images-in-a-case-of-neuronal-intranuclear-inclusion-disease
#18
Satoshi Yokoi, Keizo Yasui, Yasuhiro Hasegawa, Kazuki Niwa, Yoshinori Noguchi, Toyonori Tsuzuki, Maya Mimuro, Jun Sone, Hirohisa Watanabe, Masahisa Katsuno, Mari Yoshida, Gen Sobue
AIMS: Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder with eosinophilic intranuclear inclusion bodies. The variable symptoms of NIID increase the difficulty in an antemortem diagnosis. NIID shows leukoencephalopathy on brain magnetic resonance imaging MRI, but the significance of the radiological findings have not been clarified. METHODS: We examined an autopsied case of NIID with subcortical linear hyperintensities on diffusion weighted imaging (DWI) and leukoencephalopathy on fluid attenuation inversion recovery (FLAIR) imaging...
November 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/27641434/suspected-factitious-hypoglycemia
#19
Francesca Brett, Alan Beausang, William Tormey, Michael Curtis
No abstract text is available yet for this article.
November 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/27641433/sphenoid-bone-a-rare-site-for-giant-cell-tumor-case-report-with-literature-review
#20
Debajyoti Chatterjee, Kirti Gupta, Navneet Singla, Ankur Kapoor
While giant cell tumor is commonly a tumor of long bones, involvement of sphenoid bone is very rare. Clinically and radiologically, it mimics other neoplasms of this site. Endochondral ossification of this bone during development explains its curious preferential involvement in comparison to the rest of the skull bones. We describe an example of such a tumor arising in the sphenoid bone in a young woman and discuss the differential diagnosis. Recognizing its characteristic features is important for correct interpretation...
November 2016: Clinical Neuropathology
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