Cong Zhang, Jielian Deng, Kangjie Li, Guichuan Lai, Hui Liu, Yuan Zhang, Haijiao Zeng, Wenlong Li, Xiaoni Zhong, Yao Wang, Biao Xie
BACKGROUND: Recent research reported that frailty was prevalent among adults with chronic kidney disease (CKD) in clinical trials, and monocytes illustrated a similar difference in these two diseases compared to the normal. However, the scientific evidence for a causal relationship between these two diseases was lacking, with further exploration into whether monocytes co-regulate them. METHODS: We aimed to integrate large-scale Mendelian randomization (MR) and single-cell transcriptome analysis to determine whether there was a causal relationship between frailty and CKD (Bidirectional two-sample Mendelian determined the causal direction), whether monocytes impacted them, and whether the two diseases shared genetic variation sites...
April 3, 2024: Archives of Gerontology and Geriatrics