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Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie

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https://www.readbyqxmd.com/read/30227331/neuroprotective-effects-of-bergenia-ciliata-on-nmda-induced-injury-in-sh-sy5y-cells-and-attenuation-of-cognitive-deficits-in-scopolamine-induced-amnesia-in-rats
#1
Priyal Barai, Nisith Raval, Sanjeev Acharya, Niyati Acharya
Bergenia ciliata (Haw) Sternb. possess immunomodulatory, anti-inflammatory, antioxidant, anti-urolithiatic, wound healing, anti-malarial, anti-diabetic and anti-cancer properties. Moreover, the methanolic extracts of the rhizomes of the plant were found to demonstrate beneficial neuroprotective effects in the intracerebroventricular streptozotocin-induced model in rats. Thus, the present study was undertaken to further explore the neuroprotective potential of the aqueous (BA) and methanolic extracts (BM) of B...
September 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30227330/sirt3-mediated-cardiac-remodeling-repair-following-myocardial-infarction
#2
REVIEW
Aynaz Mihanfar, Hamid Reza Nejabati, Amir Fattahi, Zeinab Latifi, Yousef Faridvand, Masoud Pezeshkian, Ahmad Reza Jodati, Naser Safaie, Abbas Afrasiabi, Mohammad Nouri
The recent investigations have extensively focused on the importance of sirtuins, as a highly conserved family of gene products, particularly SIRT3 in various biological and pathological processes. SIRT3, the mitochondrial NAD+-dependent deacetylase has been demonstrated to target a broad range of proteins involved in the oxidative stress, ischemia-reperfusion injury, mitochondrial metabolism homeostasis and cellular death. The critical function of SIRT3 in myocardial infarction (MI), which is one of the complex phenotype of coronary artery disease and a result of interaction between various genetic and environmental factors, as well as in cardiac repair and remodeling post-MI have attracted more attention in the recent years...
September 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30227329/fibroblast-growth-factor-21-regulates-glucose-metabolism-in-part-by-reducing-renal-glucose-reabsorption
#3
Shuai Li, Nan Wang, Xiaochen Guo, Junyan Li, Teng Zhang, Guiping Ren, Deshan Li
Although previous studies have shown the potential of FGF21 to regulate blood glucose in animal and humans, the precise mechanisms of the action have not been well explored. The kidney plays a crucial role for glucose homeostasis. The purpose of this study is to explore the effect of FGF21 on renal glucose reabsorption. Administration of type 2 and type 1 diabetic mice with FGF21 reduced the transport maximum of glucose in the kidney and enhanced urinary glucose excretion in a dose-dependent manner. The inhibition of glucose reabsorption results showed little change in diabetic mice treated with Insulin...
September 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30227328/mir-545-3p-mt1m-axis-regulates-cell-proliferation-invasion-and-migration-in-hepatocellular-carcinoma
#4
Liu Changjun, Huang Feizhou, Peng Dezhen, Lei Zhao, Mao Xianhai
Studies have shown that metallothionein 1 M (MT1M) is a tumor suppressor gene which is frequently down-regulated in human hepatocellular carcinoma (HCC). The methylation of MT1M promoter region is one of the important transcriptional regulation mechanisms that contribute to the loss of its expression. In our study, we found that there are still half of the 55 HCC tumor tissues in our cohort do not share the promoter methylation of MT1M. So, we speculated there maybe another mechanism participating in the downregulation of MT1M in HCC...
September 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30227327/lncrna-thor-increases-the-stemness-of-gastric-cancer-cells-via-enhancing-sox9-mrna-stability
#5
Hu Song, Yixin Xu, Linseng Shi, Teng Xu, Ruizhi Fan, Meng Cao, Wei Xu, Jun Song
This work aims to explore the roles and mechanisms of long non coding RNA (lncRNA) THOR in regulating the stemness of gastric cancer cells. RNA-sequencing combined with quantitative real-time PCR (qRT-PCR) indicated that lncRNA THOR level was significantly upregulated in gastric cancer tissues compared with that in normal adjacent tissues. Knockdown of THOR attenuated the stemnness of gastric cancer cells, evident by the decrease of stemness markers expression and capacity of cells spheroid formation. Further RNA-sequencing combined with qRT-PCR and western blot analysis demonstrated that expression of transcriptional factor SOX9 was remarkably decreased in gastric cancer cells with THOR stable knockdown...
September 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30227326/silencing-of-cadherin-17-enhances-apoptosis-and-inhibits-autophagy-in-colorectal-cancer-cells
#6
Xia Tian, Zheng Han, Qingxi Zhu, Jie Tan, Weijie Liu, Yanfen Wang, Wei Chen, Yanli Zou, Yishan Cai, Shasha Huang, Aifang Chen, Ting Zhan, Min Huang, Meng Liu, Xiaodong Huang
Cadherin-17 (CDH17), a structurally unique member of the non-classical cadherin family, is associated with poor survival, cell proliferation, and metastasis in colorectal cancer. However, the role of CDH17 in the apoptosis and autophagy of colorectal cancer cells remains unclear. Here, we aimed to investigate the effect of CDH17 knockdown on autophagy and apoptosis in colorectal cancer cells. We inhibited CDH17 expression in KM12SM and KM12C colorectal cancer cells by RNA interference and found that silencing of CDH17 significantly inhibited cell viability and increased apoptosis in KM12SM and KM12C cells...
September 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30227325/15-hete-protects-pulmonary-artery-smooth-muscle-cells-against-apoptosis-via-sirt1-regulation-during-hypoxia
#7
Fujun Li, Yanqiu You, Hui Zhu
15-Hydroxyeicosatetraenoic acid (15-HETE) is produced by the catalytic metabolism of arachidonic acid by the enzyme 15-lipoxygenase. It is produced during hypoxia, and participates in the remodeling of pulmonary artery smooth muscle (PASM). Previous research has revealed that sirtuin 1 (SIRT1) involved in apoptosis in various cells and tissues. Herein, we attempted to determine whether 15-HETE counteracts SIRT1-promoted cell death in murine PASM cells (PASMCs). To verify this theory, we investigated changes in SIRT1 concentration in response to the counteraction of cell death by 15-HETE...
September 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30227324/linc00657-played-oncogenic-roles-in-esophageal-squamous-cell-carcinoma-by-targeting-mir-615-3p-and-junb
#8
Yuchen Sun, Jizhao Wang, Shupei Pan, Tian Yang, Xuanzi Sun, Ya Wang, Xiaobo Shi, Xu Zhao, Jing Guo, Xiaozhi Zhang
BACKGROUND: The prognosis of esophageal squamous cell carcinoma (ESCC) is relatively poor due to the absence of efficient treatment. In this manuscript, we have investigated the specific roles and molecular mechanisms of LINC00657 to order to identify novel therapeutic targets for ESCC. METHOD: The LINC00657 expression in ESCC tissues and cell lines were evaluated by quantitative real-time PCR. The expression of LINC00657 in ESCC cells was regulated by lentivirus transfection...
September 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30227323/therapeutic-effects-of-smilax-glabra-and-bolbostemma-paniculatum-on-rheumatoid-arthritis-using-a-rat-paw-edema-model
#9
Yarigui Bao, Hui Li, Qi-Yan Li, Yong Li, Fei Li, Chun-Feng Zhang, Chong-Zhi Wang, Chun-Su Yuan
Smilax glabra Roxb. (Tufuling) and Bolbostemma paniculatum (Maxim.) Franquet (Tubeimu) are used as couplet medicine in traditional Chinese medicine for the treatment of arthritis. This study is conducted to provide evidence on their therapeutic effects on rheumatoid arthritis (RA) and to explore its possible mechanisms of action. The identification and quantification of representative components (Astilbin and Tubeimoside I) in the n-butyl alcohol fraction of this couplet medicine (BFCM) were carried out by HPLC-UV assays...
September 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30227322/bergapten-inhibits-liver-carcinogenesis-by-modulating-lxr-pi3k-akt-and-idol-ldlr-pathways
#10
Shakti Prasad Pattanayak, Pritha Bose, Priyashree Sunita, Mohd Usman Mohd Siddique, Antonio Lapenna
Oxysterol receptors LXRs (α and β) are recently reported to be one of the novel and potential therapeutic targets in reducing cell proliferation and tumor growth in different system model. Activation of LXRs is correlated with modification of PI3K/Akt pathway. LXRs are also found to play a critical role in maintaining lipid homeostatais by regulating ABCA1, IDOL, SREBP1, LDLR and also certain lipogenic genes such as FASN and SCD1. In the present study a potential furanocoumarin, Bergapten (BeG) has been evaluated for its anticancer property on Hepatocellular Carcinoma (HCC) on LXR axis...
September 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30223100/genome-wide-methylation-analysis-identifies-novel-prognostic-methylation-markers-in-colon-adenocarcinoma
#11
Weinan Xue, Xiangxin Wu, Fan Wang, Peng Han, Binbin Cui
Previous studies have indicated that abnormal methylation is a critical and early event in the pathogenesis of most types of human cancer, which contributes to tumorigenesis. However, there has been little focus on the potential of DNA methylation patterns as predictive markers for the prognosis of colon adenocarcinoma (COAD). In the present study, a genome-wide comparative analysis of DNA methylation profiles was performed between 315 COAD samples and 38 matched tumor-adjacent normal tissue samples. A total of 675 differentially methylated regions (DMRs) associated with 630 genes were identified, including 654 hypermethylated regions (UMRs) and 21 hypomethylated regions, which were capable of distinguishing COAD samples from non-malignant tissue samples...
September 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30223099/possible-therapeutic-potential-of-berberine-in-the-treatment-of-stz-plus-hfd-induced-diabetic-osteoporosis
#12
Huanguang Xie, Qingqing Wang, Xinyue Zhang, Te Wang, Wei Hu, Theasha Manicum, Hua Chen, Liaojun Sun
Diabetic osteoporosis is a complication of diabetes mellitus, and can result in an increased incidence of bone fractures and a delay in fracture healing. Berberine is one of the most widely distributed isoquinoline alkaloid in plants and possesses antioxidant properties. These properties can reduce the high glucose mediated in the dysfunction of human bone marrow stem cells. Therefore, the present study was designed to investigate the apparent beneficial effect of berberine on bone characteristics in streptozotocin plus HFD-induced diabetic rats...
September 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30223098/microrna-300-nampt-regulates-inflammatory-responses-through-activation-of-ampk-mtor-signaling-pathway-in-neonatal-sepsis
#13
Yexuzi Li, Junzhong Ke, Chen Peng, Fugen Wu, Yukang Song
AIM: Rapid and accurate diagnosis of neonatal sepsis (NS) is highly warranted because of high associated morbidity and mortality. The study aims to evaluate the effects of miR-300 on inflammatory responses in a septic neonate mouse model. METHODS: A septic mouse model was established by intraperitoneal (i.p.) cecal slurry (CS) injection in order to validate the effect of miR-300 on the inflammatory response in endothelial cells. Bioinformatics tools and luciferase activity were employed to detect the target of miR-300...
September 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30223097/differential-consequences-of-neurokinin-receptor-1-and-2-antagonists-in-metastatic-breast-carcinoma-cells-effects-independent-of-substance-p
#14
Esra Nizam, Nuray Erin
INTRODUCTION: The biological action of Substance P (SP) is mediated mainly by NK-1 receptors (NK1R) followed by NK2 receptors (NK2R). Aberrant expression of NK1R and NK2R has been identified in various carcinomas. The role of Substance P and its receptors, especially NK2R in cancer progression is not entirely known and there are conflicting results in the literature demonstrating the need for further investigation. In the current study, we examined the effects of SP and antagonists selective for the NK1R and NK2R in breast carcinoma cells metastasize to vital organs...
September 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30223096/therapeutic-effects-of-honokiol-on-motor-impairment-in-hemiparkinsonian-mice-are-associated-with-reversing-neurodegeneration-and-targeting-ppar%C3%AE-regulation
#15
Hwei-Hsien Chen, Pei-Chi Chang, Shiaw-Pyng Wey, Pei-Mei Chen, Chinpiao Chen, Ming-Huan Chan
Parkinson's disease (PD) is a profound neurodegenerative disorder with gradual loss of dopamine nigrostriatal neurons linked to serious behavioral symptoms. While the current treatment strategies present limitations on halting the progression of PD, this study aimed to investigate the therapeutic potential of honokiol, as a partial peroxisome proliferator-activated receptor-gamma (PPARγ) mimic, on the proceeding behavioral and biochemical alterations in hemiparkinsonian mice. Results showed that unilateral striatal 6-hydroxydopamine (6-OHDA)-lesioned mice exhibited motor impairment, reflecting the contralateral rotation induced by apomorphine at 1-3 weeks post-lesion...
September 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30219682/lipocalin-2-protects-against-renal-ischemia-reperfusion-injury-in-mice-through-autophagy-activation-mediated-by-hif1%C3%AE-and-nf-%C3%AE%C2%BAb-crosstalk
#16
Shujuan Qiu, Xuexun Chen, Yunyan Pang, Zhaoguang Zhang
Renal ischemia/reperfusion injury is a main cause of acute kidney injury (AKI) triggering an inflammatory response associated with infiltrating macrophages. Lipocalin-2 (Lcn2) levels correlate positively and protect against renal ischemia/reperfusion injury. However, the mechanisms remain unclear. The aim of study was to investigate the protective mechanisms of Lcn2 on renal ischemia/reperfusion injury. We found that Lcn2 deficiency significantly aggravated renal injury as evidenced by higher serum creatinine, more severe morphological injury, and increased tubular epithelial cell death in mice...
September 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30219681/effects-of-silymarin-on-angiogenesis-and-oxidative-stress-in-streptozotocin-induced-diabetes-in-mice
#17
Aline Maria Stolf, Cibele Campos Cardoso, Helen de Morais, Carlos Eduardo Alves de Souza, Luís Alexandre Lomba, Anna Paula Brandt, Jonathan Paulo Agnes, Flávia Caroline Collere, Claudia Martins Galindo, Claudia Rita Corso, Katherinne Maria Spercoski, Rosangela Locatelli Dittrich, Aleksander Roberto Zampronio, Silvia Maria Suter Correia Cadena, Alexandra Acco
The present study evaluated the effects of acute treatment with silymarin, an extract that is obtained from Silybum marianum, on angiogenesis, oxidative stress, and inflammation in normoglycemic and diabetic mice. Diabetes was induced by streptozotocin (80 mg/kg, intraperitoneal) in male Swiss mice, 6 weeks of age. A polyether-polyurethane sponge was surgically implanted in the back of the mice as a model of healing in both diabetic and normoglycemic animals that were treated with oral silymarin or water for 10 days...
September 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30219680/sinapic-acid-ameliorates-bleomycin-induced-lung-fibrosis-in-rats
#18
Mohammad Raish, Ajaz Ahmad, Mushtaq Ahmad Ansari, Abdul Ahad, Fahad I Al-Jenoobi, Abdullah M Al-Mohizea, Altaf Khan, Naushad Ali
BACKGROUND: Pulmonary fibrosis is a multifaceted disease with high mortality and morbidity, and it is commonly nonresponsive to conventional therapy. PURPOSE: We explore the possible discourse of sinapic acid (SA) against the prevention of bleomycin (BLM)-instigated lung fibrosis in rats through modulation of Nrf2/HO-1 and NF-κB signaling pathways. DESIGN/METHODS: Lung fibrosis was persuaded in Sprague-Dawley rats by a single intratracheal BLM (6...
September 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30219679/culture-filtrate-ether-extracted-metabolites-from-streptomyces-levis-abriinw111-increased-apoptosis-and-reduced-proliferation-in-acute-lymphoblastic-leukemia
#19
Behnaz Valipour, Seyede Momeneh Mohammadi, Ali Abedelahi, Behnaz Faramarzian Azimi Maragheh, Elahe Naderali, Alireza Dehnad, Hojjatollah Nozad Charoudeh
Despite the advances in the discovery of various types of anticancer drugs for curing acute lymphoblastic leukemia (ALL), their toxicity and unfavorable side effects remained as big limitations for therapeutical applications. In this regard, natural products such as Streptomyces -derived agents have shown potential applications as anticancer drugs. The present study deals with evaluating the anti-carcinogenic activity of the ether extracted metabolites derived from Streptomyces on nalm-6 and molt-4 ALL cell lines...
September 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30219678/metabolism-of-liver-cyp450-and-ultrastructural-changes-after-long-term-administration-of-aspirin-and-ibuprofen
#20
Congcong Wen, Zaishou Zhuang, Huanchun Song, Shuhua Tong, Xianchuan Wang, Yijing Lin, Haichao Zhan, Zhibin Chen, Lufeng Hu
Worldwide, aspirin and ibuprofen are the most commonly used non-steroidal anti-inflammatory drugs (NSAIDs). Some adverse reactions, including gastrointestinal reactions, have been concerned extensively. Nevertheless, the mechanism of liver injury remains unclear. In the present study, we focused on the metabolism of liver cytochrome P450 (CYP450) and ultrastructural morphology of liver cells. A total of thirty rats were divided into three groups of 10. Rats in the aspirin and ibuprofen groups were given enteric-coated aspirin (15 mg/kg) and ibuprofen (15 mg/kg), respectively by gavage for four weeks...
September 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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