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Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie

Nahid Aboutaleb, Hosein Jamali, Maryam Abolhasani, Hamidreza Pazoki Toroudi
Renal ischemia/reperfusion (I/R) injury following kidney transplantation has been found to be a great clinical problem owing to initiation of acute inflammatory responses and subsequently rapid loss of kidney function. It is well known that lavender oil exhibits an extensive spectrum of pharmacological and biochemical activities. The purpose of this study was to clarify molecular targets of lavender in treatment of this disease. Male Wistar rats weighing 200-250 g were divided into three major groups: sham, I/R, and I/R + different doses of lavender oil (L1:50 mg/kg, L2: 100 mg/kg, and L3: 200 mg/kg)...
November 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sonia Gioffré, Veronica Ricci, Chiara Vavassori, Clarissa Ruggeri, Mattia Chiesa, Ivana Alfieri, Silvia Zorzan, Marta Buzzetti, Giuseppina Milano, Alessandro Scopece, Laura Castiglioni, Luigi Sironi, Giulio Pompilio, Gualtiero I Colombo, Yuri D'Alessandra
BACKGROUND: Doxorubicin (DOX) is a chemotherapeutic drug limited in its usefulness by an adverse side effect, cardiotoxicity. The mechanisms leading to this detrimental occurrence are not completely clear, and lately many authors focused their attention on the possible role of microRNAs (miRNAs), small regulators of cardiovascular functions, in this phenomenon. Notably, these molecules recently emerged also as potential circulating biomarkers of several cardiac diseases. Thus, the aim of this study was the simultaneous investigation of circulating and cardiac tissue miRNAs expression upon DOX treatment in vivo...
November 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Shengli Wang, Shuguang Zuo, Zhigang Liu, Xinying Ji, Zhenqiang Yao, Xinchun Wang
No abstract text is available yet for this article.
November 6, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara
Rose oil has traditionally been used to treat psychiatric disorders, but the scientific basis of this treatment remains poorly understood. The main odor component of rose oil is 2-phenylethanol (2-PE), but the neuropsychological effects of 2-PE have not been investigated in detail. Thus, we aimed to investigate the effects of 2-PE on mouse behavior. We first investigated whether 2-PE is attractive or repulsive to mice. After 2-PE inhalation, the mice underwent a series of behavioral experiments, such as the elevated plus maze, open field, Y-maze, tail-suspension, and Porsolt forced-swim tests...
November 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Chih-Chao Yang, Yen-Ta Chen, Christopher Glenn Wallace, Kuan-Hung Chen, Ben-Chung Cheng, Pei-Hsun Sung, Yi-Chen Li, Sheung-Fat Ko, Hsueh-Wen Chang, Hon-Kan Yip
This study tested the hypothesis that early administration of empagliflozin (Empa), an inhibitor of glucose recycling in renal tubules, could preserve heart function in cardiorenal syndrome (CRS) in rat. Chronic kidney disease (CKD) was caused by 5/6 subtotal nephrectomy and dilated cardiomyopathy (DCM) by doxorubicin (DOX) treatment. In vitro results showed that protein expressions of cleaved-caspase3 and autophagy activity at 24 h/48 h in NRK-52P cells were significantly upregulated by para-Creso treatment; these were significantly downregulated by Empa treatment...
November 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Camila Camponogara, Rosana Casoti, Indiara Brusco, Mariana Piana, Aline A Boligon, Daniela Almeida Cabrini, Gabriela Trevisan, Juliano Ferreira, Cássia Regina Silva, Sara Marchesan Oliveira
ETHNOPHARMACOLOGICAL RELEVANCE: Tabernaemontana catharinensis, popularly known as snakeskin, is used in traditional medicine to treat skin inflammatory disorders. To confirm the topical anti-inflammatory effect of T. catharinensis leaves, we evaluated the therapeutic effect of crude extract (TcE) and its different fractions on irritant contact dermatitis model in mice and verified its anti-inflammatory action mechanism. MATERIALS AND METHODS: The qualitative phytochemical analysis of TcE and its dichloromethane, n-butanol and ethyl acetate fractions was performed by UHPLC-ESI-HRMS...
November 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Francielle Graus-Nunes, Vanessa Souza-Mello
Local renin-angiotensin system (RAS) in the pancreas is linked to the modulation of glucose-stimulated insulin secretion (GSIS) in beta cells and insulin sensitivity in target tissues, emerging as a promising tool in the prevention and/or treatment of obesity, diabetes, and systemic arterial hypertension. Insulin resistance alters pancreatic islet cell distribution and morphology and hypertrophied islets exhibit upregulated angiotensin II type 1 receptor, which drives oxidative stress, apoptosis, and fibrosis, configuring beta cell dysfunction and diminishing islet lifespan...
November 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Kholoud M El-Shewy, Ahmad Kunbaz, Mohamed M Gad, Muneer J Al-Husseini, Anas M Saad, Yasser M Sammour, Mohamed M Abdel-Daim
Chronic pain is one of the most common clinical presentations in the primary care settings. In the US, Fibromyalgia (FM) affects about 1-3% of adults and commonly occurs in adults between the ages of 40-50 years. FM causes widespread muscular pain and tenderness with hyperalgesia and allodynia and may be associated with other somatic complaints. Hyperbaric oxygen therapy (HBOT) has been utilized and has recently shown promising effects in the management of FM and other chronic pain disorders. In HBOT, the intermittent breathing of 100% oxygen in a pressurized chamber where the pressure is higher than 1 atmosphere absolute (ATA) has been utilized...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Lin Wang, Ling Zhao, Xiaomeng Jia, Lina Jiang, Yeqiong Song, Qinong Ye, Zhaohui Lyu
Aminophenols, which are widely used as components of hair dye and medicine, may function as environmental endocrine disruptors by regulating the proliferation of endocrine-related cancers. Estrogen receptor α (ERα) is a key regulator of breast cancer. Recently, it was found that ERα may also participate in the transformation and progression of thyroid tumors, but its interaction with aminophenols and its function in thyroid tumors is not clear. In this study, the transcription factor activity of ERα in BHP10-3 cells (a thyroid tumor cell line) was examined using luciferase assays...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Marina Barcelos de Miranda, Mariana Ferreira Lanna, Ana Luiza Barros Nascimento, Carmen Aparecida de Paula, Marcelo Eustáquio de Souza, Mariane Felipetto, Lucíola da Silva Barcelos, Sandra Aparecida Lima de Moura
The occurrence of inflammation and protein malnutrition is an aggravating risk factor for morbidity and mortality in the clinical setting. The green propolis, a natural product made by Apis mellifera bees from Baccharis dracunculifolia resin, has therapeutic potential to modulate chronic inflammation. However, its effect on inflammation in an impaired nutritional status is not known. The aim of this study was to characterize the effects of the administration of the hydroalcoholic extract of the green propolis in the chronic inflammatory process of mice submitted to a low-protein diet...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jiahui Zhao, Qingli Cheng, Yang Liu, Guang Yang, Xiaohua Wang
This study aimed to examine the effects of atorvastatin on early hypertensive renal damage and explored the underlying mechanisms. 12-week-old salt-loaded spontaneous hypertensive rats (SHRs) were divided into four groups: atorvastatin (AVT), losartan potassium (LP), atorvastatin combined with peroxisome proliferators-activated receptor γ (PPAR-γ) inhibitor (AVT + GW9662), and saline. During 10 weeks administration blood pressure and urea albumin creatinine ratio were determined. We also examined the renal function, pathological changes of kidney, inflammatory cytokines in the serum and the association of the change of inflammatory factors in the kidney tissue...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jing Jiang, Chuanmei Xie, Yujuan Liu, Qi Shi, Yan Chen
MicroRNAs are small non-coding RNAs which play important roles in tumor progression. MiR-383-5p has been characterized as a cancer suppressor in several cancers. The aim of theses present study was to explore the role of miR-383-5p in the proliferation and chemosensitivity of ovarian cancer cells. MiR-383-5p expression was down-regulated while the expression of TRIM27 was up-regulated in ovarian cancer tissues and cell lines. We came up with the hypothesis that miR-383-5p might be involved in the tumor progression and chemoresistance of ovarian cancer through targeting TRIM27...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sahar Alijanpour, Fatemeh Khakpai, Mohaddeseh Ebrahimi-Ghiri, Mohammad-Reza Zarrindast
It is now well-established that orexins (OXs) and their receptors are involved in the pathophysiology of depression. Considering the evidence indicating the importance of nitric oxide (NO) system in the mood modulation, this study investigated the effect of intraperitoneal (i.p.) administration of orexin 1 (OX1) receptor antagonist -SB334867- alone or in combination with NO agents on depression using the forced swimming test (FST), tail suspension test (TST) and the number of crossings in open-field test (OFT) in mice...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Reyhaneh Naderi, Saeed Esmaeili-Mahani, Mehdi Abbasnejad
Abscisic acid (ABA), a critical phytohormone, is also produced in animal tissues. It has been reported that ABA has pro-cognitive and anti-anxiety effects in rats. However, its detailed mechanism has not yet been clarified. Here, the possible roles of extracellular and intracellular calcium store and ERK signaling were evaluated in pro-cognitive and anti-anxiety effects of ABA. Morris water maze (MWM) and plus maze tests were used to evaluate the learning and memory and anxiety-like behavior, respectively, in rats...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
She-Ji Weng, De-Yi Yan, Jia-Hao Tang, Zi-Jian Shen, Zong-Yi Wu, Zhong-Jie Xie, Jia-Yi Yang, Bing-Li Bai, Liang Chen, Viraj Boodhun, Lin Yang, Xiang Da Eric Dong, Lei Yang
Accumulating evidence suggests that improvements in osteogenesis and angiogenesis play an important role in repairing osteoporotic bone defects. Cinnamomum cassia (C. cassia), a traditional Chinese medicinal herb, is reported to show anabolic effects on osteoblasts. However, whether C. cassia could actually repair bone defects in osteoporotic conditions remains unknown. The purpose of this study was to evaluate the effect of combined treatment with Cinnamaldehyde (main oil isolated from the C. cassia) and β-tricalcium phosphate (β-TCP) on bone formation and angiogenesis in critical size calvarial defects in ovariectomized (OVX) rats...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Changjie Lou, Haibo Lu, Zhigang Ma, Chao Liu, Yanqiao Zhang
Gemcitabine resistance will occur by time after the initial response in pancreatic cancer. Ginkgolide B (GB), a major terpene lactone component of Ginkgo biloba leaves, is a highly selective and competitive inhibitor for platelet-activating factor (PAF) receptor. In the present study, we evaluated the effect of GB on gemcitabine sensitivity in pancreatic cancer cell lines in vitro and in vivo. Cell viability assay, flow cytometry, dual luciferase reporter assay and tumor xenograft model were used to evaluate cell proliferation, apoptosis, nuclear factor kappa b (NF-кB) activity in vitro and tumor growth in vivo...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jie Ren, Lixia Li, Yue Wang, Jingchen Zhai, Guangtong Chen, Kun Hu
Gambogic acid (GA), a natural product with a xanthone structure, was previously demonstrated to exert anti-inflammatory effects. The aim of this study was to evaluate the anti-inflammatory activity of GA on LPS-stimulated mouse macrophage RAW264.7 and its anti-inflammatory mechanism. Pretreatment with GA inhibited LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2) through reducing the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). GA also decreased the expressions of pro-inflammatory cytokines, including TNF-α, IL-6 and IL-1β...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Chen Chen, Qi-Di Ai, Shi-Feng Chu, Zhao Zhang, Nai-Hong Chen
As a vital cell type in immune system and infiltrating cells in ischemic brain, NK cells can bridge the crosstalk between immune system and nervous system in stroke setting. The mechanism of action of NK cells is complicated, involving direct and indirect actions. NK cells are closely associated with poststroke inflammation, immunodepression and infections. The excessive inflammatory response in ischemic brain is one of the important causes for aggravating cerebral ischemic injury. Besides the inflammation induced by ischemia itself, thrombolytic drug tissue plasminogen activator (tPA) administration could also induce deteriorative inflammation, which is unfavorable for stroke control and recovery...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Benneth Ben-Azu, Ekene Enekabokom Nwoke, Adegbuyi Oladele Aderibigbe, Itivere Adrian Omogbiya, Abayomi Mayowa Ajayi, Elizabeth Toyin Olonode, Solomon Umukoro, Ezekiel O Iwalewa
Flavonoids are naturally occurring bioactive phytochemical metabolites widely known to prevent and suppress several human diseases, and are important sources of therapeutic compounds from plants. Evidence derived from previous studies suggests that naringin, a neuroactive flavonoid possess functional beneficial neurobehavioral effects including anxiolytic, antidepressant and memory enhancing properties. However, literature search revealed that no studies have been carried out to evaluate the possible biochemical mechanisms involved in the neurobehavioral property of naringin alone following repeated treatment...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jiwei Li, Li Wei
Non-small cell lung cancer (NSCLC), the most prevalent type of lung cancer, is one of the most leading causes of cancer-related morbidity and mortality worldwide. Evidence is accumulating that long non-coding RNAs (lncRNAs) play vital regulatory roles in tumor development and progression. LINC01510, a novel tumor-related lncRNA, has been identified as an oncogene in colorectal cancer; however, its role in NSCLC remains poorly understood. This study aimed to characterize the biological role of LINC01510 in NSCLC and illuminate the molecular mechanisms...
November 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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