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Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie

Tao-Li Wang, Chen-Sheng Ouyang, Li-Zhu Lin
Lung cancer is the leading cause of cancer death worldwide. Chemotherapy is one of the most effective strategies for lung cancer treatment. However, the side effects of chemotherapy limit the application of chemotherapeutic agents. The β-Asarone, a low-toxicity natural compound from a traditional Chinese medicinal herb, has been demonstrated to display anticancer activities in multiple cancer types. However, the anticancer activities of β-Asarone in lung cancer have not been shown, and the underlying molecular mechanisms are still unclear...
July 7, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Shengli Wang, Shuguang Zuo, Zhigang Liu, Xinying Ji, Zhenqiang Yao, Xinchun Wang
OBJECTIVE: To discuss the curative effect and security of triptolide (TPL) on TNF transgenic (TNF-Tg) mice with rheumatoid arthritis (RA), and to explore the mechanism primarily. METHOD: 40 TNF-Tg RA mice were randomlydivided into five groups averagely: the control group, low-dose group (3.3 μg/kg/d TPL), middle-dose group (10 μg/kg/d TPL), high-dose group (33 μg/kg/d TPL) and MTX group (0.1 mg/kg/d MTX). Mice were administrated five days a week for six weeks...
July 7, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yun-Yi Yan, Lu-Yao Ao, Lin Zhou, Cheng-Yuan Li, Wei-Rong Fang, Wei-Yang Shen, Bing-Wen Liang, Xiong Zhu, Yun-Man Li
(3β,5α,16α,20S)-4,4,14-trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol-dihydrochloride (JLX001), a derivative of cyclovirobuxine D (CVB-D), is a novel compound from synthesis. This study aims to confirm the therapeutic effect of JLX001 on cerebral ischemia and researchits antiplatelet and antithrombosis activities via thromboxane (TXA2 )/phospholipase C-β-3(PLCβ3)/protein kinase C (PKC) pathway suppression. The therapeutic effects of JLX001 was evaluated by infarct sizes, brain edema and neurological scores in Sprague-Dawley (SD) rats with middle cerebral artery occlusion (MCAO)...
July 7, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yong-Qiang Zhang, Zhong-Hang Wen, Ke Wan, Dongbo Yuan, Xiaoping Zeng, Guangyi Liang, Jianguo Zhu, Bixue Xu, Heng Luo
Leukemia is a hematologic malignancy with poor prognosis in humans and chemotherapy is the main strategy for treating leukemia patients. Novel drugs with better selectivity and lower toxicity are required for the treatment of patients. A novel 3',5'-diprenylated chalcone, (E)-1-(2-hydroxy-4-methoxy-3,5-diprenyl) phenyl-3-(3- pyridinyl)-propene-1-one (C10) is a potential new anti-leukemia agent. In this study, we investigated the molecular mechanisms of the anti-leukemia effects of C10 on different leukemia cells in vitro...
July 6, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Aya M Zaki, Dalia M El-Tanbouly, Rania M Abdelsalam, Hala F Zaki
Ischemia-reperfusion (I/R) injury is a pathological process which magnifies with the ensuing inflammatory response and endures with the increase of oxidants especially during reperfusion. The present study was conducted to assess the possible modulatory effects of plumbagin, the active constituent extracted from the roots of traditional medicinal plant Plumbago zeylanica L., on the dire role of high mobility group box 1 (HMGB1) as well as the associated inflammation, oxidative stress and apoptotic cell death following hepatic I/R...
July 6, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Qiang Su, Xiangwei Lv, Yuhan Sun, Ziliang Ye, Binghui Kong, Zhenbai Qin
Coronary microembolization (CME) is a common complication during the treatment of acute coronary syndrome (ACS) and percutaneous coronary intervention (PCI). Nicorandil can be used to prevent myocardial injury after PCI to reduce the incidence of coronary no-reflow and slow flow, and play a role in myocardial protection, suggesting that its mechanism may be related to the inhibition of CME-induced inflammation of cardiomyocytes. However, the specific mechanism remains unclear. This study investigated the myocardial protective effects of nicorandil pretreatment on CME-induced myocardial injury and the specific mechanism of its inhibition of myocardial inflammation...
July 6, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Hatice Gumushan Aktas, Tuba Akgun
In this study, we investigated the potential effects of naringenin on the motility of MAT-LyLu cells, which overexpress voltage-gated sodium channels and whose metastatic behaviours are associated with these channels. We first determined the concentration of naringenin that did not show toxic effects or block cell growth. Then, the effects of naringenin on cell motility in the lateral and vertical directions were tested by wound healing assays and transwell invasion assays, respectively. Finally, to determine the suppressive effects of naringenin on cell movement in both directions, the expression of the SCN9A gene, which encodes Nav1...
July 6, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Saeid Afshar, Rezvan Najafi, Abdolazim Sedighi Pashaki, Mohammadreza Sharifi, Safoora Nikzad, Mohammad Hadi Gholami, Alireza Khoshghadam, Razieh Amini, Jamshid Karimi, Massoud Saidijam
OBJECTIVE: Radioresistance is a significant obstacle for effective treatment of colorectal cancer (CRC). Recent studies have indicated that miR-185 inhibits proliferation, survival, and invasion of CRC; however, the role of this miRNA in radioresistance of CRC has not been identified yet. The aim of this study is to investigate the role of miR-185 in radiosensitivity of CRC. METHODS: After transfecting the cells with mimic miR-185, expressions of IGF1R and IGF2 were evaluated by real-time PCR and western blot...
July 6, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Hongyan Zhang, Yuan Wang, Jibin Lu, Yanyan Zhao
Recent evidence indicates that long noncoding RNAs (lncRNAs) play a critical role in the regulating cellular processes such as differentiation, proliferation, metastasis and apoptosis. These lncRNAs are found to be dysregulated in a variety of cancers. However, the underlying mechanisms of lncRNAs action in lung adenocarcinoma remain unclear. We investigated expression of the lncRNA LINC00222 in 76 lung adenocarcinoma tissues and paired normal lung tissues and found that LINC00222 is downregulated in lung adenocarcinoma tissues...
July 6, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Miao He, Yu Zhang, Fei Xie, Xuejiao Dou, Ming Han, Hong Zhang
BACKGROUND: Apoptosis is a cellular mechanism contributing to cardiac surgery using cardiopulmonary bypass (CPB)-induced lung injury. The ubiquitous PI3K/Akt pathway regulates proliferation, apoptosis and differentiation by controlling a broad range of target proteins including NF-κB and GSK-3β. The roles of the PI3K/Akt/NF-κB and PI3K/Akt/GSK-3β pathways in CPB-related lung injury are unclear. METHODS: Seventy-two male Sprague-Dawley rats were assigned into sham, CPB, Wortmannin (Wtn) and insulin-like growth factor-I (IGF-I) groups (n = 18, each)...
July 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Hao Hu, Jiawei Wu, Dan Li, Junling Zhou, Hua Yu, Likun Ma
BACKGROUND: Long noncoding RNA (LncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is involved in the development of acute myocardial infarction (AMI). However, the molecular mechanism and biological function of MALAT1 in AMI remained unclear. METHODS: The expression levels of MALAT1, miR-320 and phosphatase and tensin homolog deleted on chromosome 10 (Pten) in a mouse model of AMI and sham-operated mice were determined by quantitative real-time PCR (qRT-PCR) and western blotting, respectively...
July 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yanbo Fan, Zhiwei He, Wei Wang, Jingjing Li, Aimin Hu, Li Li, Ling Yan, Zhijie Li, Qiang Yin
AIM: Previous clinical studies have demonstrated that tangganjian (TGJ), a modern Chinese prescribed medicine, has a clinical effect in the treatment of type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD). Our study aimed to investigate whether the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway is involved in this therapeutic effect. MATERIALS AND METHODS: T2DM and NAFLD rat models were constructed and treated with three different concentrations of TGJ...
July 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Junaid Jibran Jawed, Sayantan Banerjee, Syamdas Bandyopadhyay, Shabina Parveen, Bidisha Paul Chowdhury, Prasanta Saini, Subrata Majumdar
NOD like receptors (NLR) are essential pathogen associated molecular pattern receptors of cytoplasmic origin. During several intracellular parasitic infections NLR played vital role for host protective immune response against the pathogen. Amongst various classes of NLR, NOD1 and NOD2 had been extensively studied and were found to be the most active member of the NLR family. Therefore, we wanted to study the role of NOD1/NOD2 during Leishmania donovani infection and the mechanism behind the utilization of this pathway as a therapeutic approach...
July 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Awais Ullah Ihsan, Farhan Ullahp Khan, Puregmaa Khongorzul, Khalil Ali Ahmad, Muhammad Naveed, Sufia Yasmeen, Yanfang Cao, Abdoh Taleb, Richinandan Maiti, Fahad Akhter, Xiaoqian Liao, Xue Li, Yijie Cheng, Hidayat Ullah Khan, Khurshid Alam, Xiaohui Zhou
Oxidative stress (OS) is a result of the imbalance between reactive oxygen species (ROS) and antioxidants in the body that can cause tissue damage. Oxidative stress has a significant involvement in the pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and male infertility. CP/CPPS is a major risk factor for male infertility due to generation of excessive ROS that damage sperm DNA, lipids, and proteins, resulting in compromised vitality and decreased sperm motility. Here we present a comprehensive review of oxidative stress relevance in CP/CPPS and male infertility, and embody the protective effects of antioxidants against ROS...
July 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Vamshi Krishna Rapalli, Gautam Singhvi, Sunil Kumar Dubey, Gaurav Gupta, Dinesh Kumar Chellappan, Kamal Dua
Psoriasis is a chronic autoimmune skin disorder affecting 2-3% of the world population. It has characteristic features such as increased keratinocyte proliferation and production of inflammatory mediators. The treatment involves various strategies including topical, systemic, phototherapy and biologics. Topical therapies are preferred for mild to moderate psoriasis conditions over the systemic therapies which are ideal in severe disease conditions. The systemic therapies include immunosuppressants, biological agents and recently approved phosphodiesterase-4 (PDE4) inhibitors...
July 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Evangeline Breeta R, Perinba Danisha Jesubatham, Berlin Grace V M, Viswanathan S, Srividya S
Lung cancer is a malignant tumour with minimal survival rate and the current treatments are not showing complete remission of tumour and have many side effects. Thus a natural herbal medicine with good anti-cancer properties is highly demanded. Thuja orientalis L. is a traditionally used medicine to cure cough, bronchitis, excessive menstruation, asthma, skin infection and premature baldness. In addition, recent studies have revealed that it has anti-proliferative and anti-cancer activity. Angiogenesis is the main reason for the propagation and metastasis of cancers...
July 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Liman Luo, Xiaoyang Hong, Bo Diao, Siyao Chen, Mingyan Hei
OBJECTIVE: This study investigated the impact of SO2 on rats with hypoxic pulmonary vascular structural remodeling and its possible mechanisms. MATERIALS AND METHODS: Pulmonary vascular morphological change was examined by HE staining. RNA-based high-throughput sequencing (RNA-seq) was performed to detect differential expression of mRNAs in Normal and Hypoxia-induced Pulmonary hypertension (HPH) rats. The Real-time quantitative RT-PCR (q RT-PCR) was used for validation of wnt7b, sfrp2, cacna1f, DKK1, CaSR and vimentin mRNA expression levels...
July 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Tamotsu Tsukahara, Shuhei Yamagishi, Yoshikazu Matsuda, Hisao Haniu
We previously showed that an alkyl-ether analog of lysophosphatidic acid, AGP (alkyl-glycerophosphate), accumulates in human atherosclerotic plaques and is a potent agonist of peroxisome proliferator-activated receptor-gamma (PPARγ). On the other hand, cyclic phosphatidic acid (cPA), similar in structure to AGP, can negatively regulate PPARγ. However, in this study, cPA had no effect on the expression and secretion of C-C motif chemokine 2 (CCL-2), a chemokine that is also linked to inflammatory responses and atherosclerosis...
July 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Cheng-Dao Hua, Er-Bao Bian, Er-Feng Chen, Zhi-Hao Yang, Feng Tang, Hong-Liang Wang, Bing Zhao
Malignant glioma is one of the most common primary human tumors in the central nervous system. The molecular mechanisms of the progression and development of glioma have been largely unexplored. In this study, we illustrated that the expression of Dok7 was downregulation in human glioma tissues. Dok7 overexpression significantly inhibits proliferation and colony formation in vitro, and the xenograft tumor formation in vivo. In addition, 5-Aza-2'-deoxycytidine (5-Aza), a DNA methylation inhibitor, preventing the loss of Dok7 expression by decreasing aberrant hypermethylation of Dok7 promoter in glioma cells...
July 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Xiaoyan Wang, Mingqing He, Jianzhong Li, Haiying Wang, Jianan Huang
Krüppel-like factors (KLFs) are transcription factors containing three different C2H2-type zinc finger domains in their carboxy-terminal regions which have been identified to play important roles in a variety of cancers. However, little is known about KLF15 in lung adenocarcinoma (LAUD). Our study demonstrated that the expression levels of KLF15 were observably down-regulated in LAUD tissues compared to paired adjacent normal tissues. LUAD patients with low expression levels of KLF15 have worse prognosis than those with high expression levels of KLF15...
July 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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