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Acta Otorhinolaryngologica Italica

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https://www.readbyqxmd.com/read/27897275/an-ex-vivo-model-contributing-to-the-diagnosis-and-evaluation-of-new-drugs-in-cystic-fibrosis
#1
A M Di Lullo, M Scorza, F Amato, M Comegna, V Raia, L Maiuri, G Ilardi, E Cantone, G Castaldo, M Iengo
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene. About 2000 mutations have been described so far. We setup an ex vivo model of human nasal epithelial cells (HNECs) to study CF patients testing the effect of novel mutations and molecular therapies. We performed the sampling (by brushing), followed by culture and analysis of HNECs using a series of molecular techniques. We performed 50 brushings from CF patients and controls...
November 29, 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27897274/modelling-tumour-volume-variations-in-head-and-neck-cancer-magnetic-resonance-imaging-contribution-for-patients-undergoing-induction-chemotherapy
#2
N Dinapoli, T Tartaglione, F Bussu, R Autorino, F Miccichè, M Sciandra, E Visconti, C Colosimo, G Paludetti, V Valentini
Primary tumour volume evaluation has predictive value for estimating survival outcomes. Using volumetric data acquired by MRI in patients undergoing induction chemotherapy (IC) these outcomes were estimated before the radiotherapy course in head and neck cancer (HNC) patients. MRI performed before and after IC in 36 locally advanced HNC patients were analysed to measure primary tumour volume. The two volumes were correlated using the linear-log ratio (LLR) between the volume in the first MRI and the volume in the second...
November 29, 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27600105/surgical-treatment-of-sporadic-vestibular-schwannoma-in-a-series-of-1006-patients
#3
Z Zhang, Y Nguyen, D De Seta, F Y Russo, A Rey, M Kalamarides, O Sterkers, D Bernardeschi
The management of sporadic vestibular schwannoma (VS) has evolved in the last decades. The aim of this study was to analyse the evolution in surgical outcomes of VSs operated by a neurotological team between 1990 and 2006 by different approaches. A monocentric retrospective review of medical charts of 1006 patients was performed. In order to assess eventual changes and progress, the 17-years period was divided in three periods, each one comprehending 268 VS (1990-1996), 299 VS (1997-2001), and 439 VS (2002-2006)...
September 6, 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27600104/3d-curved-multiplanar-cone-beam-ct-reconstruction-for-intracochlear-position-assessment-of-straight-electrodes-array-a-temporal-bone-and-clinical-study
#4
D De Seta, P Mancini, F Y Russo, R Torres, I Mosnier, J L Bensimon, E De Seta, D Heymann, O Sterkers, D Bernardeschi, Y Nguyen
A retrospective review of post-op cone beam CT (CBCT) of 8 adult patients and 14 fresh temporal bones that underwent cochlear implantation with straight flexible electrodes array was performed to determine if the position of a long and flexible electrodes array within the cochlear scalae could be reliably assessed with CBCT. An oto-radiologist and two otologists examined the images and assessed the electrodes position. The temporal bone specimens underwent histological analysis for confirm the exact position...
September 6, 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734988/arterio-venous-malformation-of-the-mandible-case-report-and-review-of-literature
#5
R Spreafico, L Sordo, R Bellotto, M Schipano, A Rescaldani, F Parmigiani
Arteriovenous malformation (AVM) of the head and neck is a rare and potentially life threatening entity due to massive haemorrhage. There are several indications for treatment, including age of the patient and location, extent and type of vascular malformation. Endovascular therapy can effectively cure most lesions with limited tissue involvement. Surgery can be used in selected cases in combination with embolization. Here we report the case of a young woman affected by a massive AVM on the left side of the mandible and submandibular region, and also review the literature on AVM with special attention to treatment strategies...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734987/the-relevance-of-counseling-in-patients-with-nasal-polyps
#6
M Gelardi, N De Candia, N Quaranta, C Russo, P Pecoraro, M Mancini, P Luperto, G Lombardo, A Macchi, C Bocciolini, A Ciofalo, E De Corso, G Ciprandi
No abstract text is available yet for this article.
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734986/vastus-lateralis-myofascial-free-flap-in-tongue-reconstruction
#7
R Pellini, A De Virgilio, G Mercante, B Pichi, V Manciocco, P Marchesi, F Ferreli, G Spriano
In the last decade, the antero-lateral thigh free flap (ALT) has become the most popular free flap for tongue reconstruction because of less donor site morbidity and better cosmetic outcomes. However, fascio-cutaneous ALT may be insufficient to reconstruct major tongue defects, while its muscular-cutaneous variant (using the vastus lateralis muscle) may be too bulky. The present study describes our preliminary experience of tongue reconstruction with vastus lateralis myofascial flap, which could potentially offer unique advantages in head and neck reconstruction including adequate bulk when needed, optimal functional results and obliteration of dead space thus preventing fistulas and infections with minimal morbidity...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734985/prevention-of-bisphosphonate-related-mandibular-fractures
#8
M Pedrazzoli, L Autelitano, F Biglioli
Mandibular fracture is usually the clinical end of bisphosphonate-related osteonecrosis of the jaw. This is a painful complication and patients cannot feed as usual, with a worsening of their quality of life. The goal of treatment in bisphosphonate related osteonecrosis of jaw (BRONJ) patients is to slow progression of bone necrosis. We present a novel technique for treatment of severe mandibular BRONJ in stage 3 patients that present with a high risk to develop fracture, since they have a residual unaffected mandibular bone height less than 6 mm...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734984/possibility-of-differentiation-of-cochlear-electrodes-in-radiological-measurements-of-the-intracochlear-and-chorda-facial-angle-position
#9
I Diogo, U Walliczeck, J Taube, N Franke, A Teymoortash, J Werner, C Güldner
Due to an increasing number of cochlear implantations, quality control has become more important. In addition to intraoperative biophysical measurements, radiological imaging is another possibility. An upcoming technique regarding this is Cone Beam CT (CBCT). Sixty-five data sets (35 Nucleus Contour Advance-Cochlear; 30 Flex Soft-MedEl) of postoperative imaging by CBCT (Accu-I-tomo F17, Morita, Kyoto, Japan) underwent further evaluation. Insertion angle, height of the cochlea, distance of the electrode to the medial or lateral wall, angle between chorda tympani and facial nerve and the precise position of the electrode cable in the facial-chordal angle were determined...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734983/monolateral-sinonasal-complications-of-dental-disease-or-treatment-when-does-endoscopic-endonasal-surgery-require-an-intraoral-approach
#10
G L Fadda, M Berrone, E Crosetti, G Succo
The widespread use of dental implants and reconstructive procedures for their positioning has led to an increase in sinonasal complications of dental disease and treatment (SCDDT). Diagnosis requires accurate dental and rhinological evaluation, including computed tomography (CT). The aim of this study is to investigate a multidisciplinary approach for the treatment of SCDDT by combining endoscopic endonasal surgery (EES) and an intraoral approach on the basis of a preliminary classification system already proposed by other authors...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734982/evaluation-of-pharyngeal-muscle-activity-through-nasopharyngeal-surface-electromyography-in-a-cohort-of-dysphagic-patients-with-acute-ischaemic-stroke
#11
N M Giannantoni, M Minisci, V Brunetti, E Scarano, E Testani, C Vollono, E De Corso, G Bastanza, L D'Alatri, G Della Marca
Oro-pharyngeal dysphagia is frequently present during the acute phase of stroke. The aim of the present study was to evaluate whether the recording of surface EMG using a nasopharyngeal (NP) electrode could be applied to evaluation of pharyngeal muscle activity in acute stroke patients and if this neurophysiological measure is related with clinical assessment of swallowing. Patients were examined and clinical severity was assessed with the National Institute of Health Stroke Scale (NIHSS) score; dysphagia was evaluated through bedside screening test using the Gugging Swallowing Scale (GUSS)...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734981/malignant-salivary-gland-tumours-of-the-larynx-a-single-institution-review
#12
S Karatayli-Ozgursoy, J A Bishop, A T Hillel, L M Akst, S R Best
Malignant salivary gland tumours of the larynx are very rare, with limited reports of clinical outcomes. We present the decade-long experience of a single institution. A 10-year retrospective chart review of a tertiary head and neck cancer centre was performed. Index patients were identified from a review of a pathology database, and reviewed by a head and neck pathologist. Patient demographics, presenting signs and symptoms, treatment modalities and clinical outcomes were extracted from electronic medical records...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734980/role-of-kabat-rehabilitation-in-facial-nerve-palsy-a-randomised-study-on-severe-cases-of-bell-s-palsy
#13
S Monini, C M Iacolucci, M Di Traglia, A I Lazzarino, M Barbara
The treatment of Bell's palsy (BP), based on steroids and/or antiviral drugs, may still leave a certain percentage of affected subjects with disfiguring sequelae due to incomplete recovery. The different procedures of physical rehabilitation have not been demonstrated to play a favourable role in this disorder. The aim of the present study was to compare functional outcomes in severe cases of Bell's palsy when treated by steroids alone or by steroids accompanied by Kabat physical rehabilitation. This prospective study included 94 subjects who showed sudden facial nerve (FN) palsy with House-Brackmann grade IV or V and who were divided into two groups on the basis of the therapeutic approach: one group (a) was treated by steroids, and the other (b) received steroids in combination with physical rehabilitation...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734979/the-audiological-and-take-results-of-perichondrium-attached-cartilage-island-graft-in-tympanoplasty-pacit
#14
F Solmaz, D Akduman, M Haksever, E Gündoğdu, M Yanılmaz, A Mescioğlu
Cartilage is one of the most preferable grafts for tympanoplasty (TPL). The anatomical and audiological results and take rates of perichondrium attached cartilage island graft in tympanoplasty (PACIT) are presented herein. One hundred ninety four ears of 191 patients (108 male, 83 female) were evaluated retrospectively in terms of the type of surgery, graft take rate and hearing results. Type I, II, and III TPL were performed in 127 (65.46%), 45 (23.20%), and 22 (11.34%) ears, respectively. The overall mean preoperative pure tone average-air bone gaps (PTA-ABGs) for TPL types were 33...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734978/surgical-complications-in-orbital-decompression-for-graves-orbitopathy
#15
S Sellari-Franceschini, I Dallan, A Bajraktari, G Fiacchini, M Nardi, R Rocchi, C Marcocci, M Marinò, A P Casani
The objective of this study is to analyse the complications of orbital decompression in Graves' orbitopathy. The clinical records of 946 patients who had been operated on with orbital decompression for Graves' orbitopathy were reviewed and the intra- and post-operative complications with minimum follow-up of six months were analysed. An extensive review of the literature was carried out to compare results. In the case-series reported here the most frequent complications were: wasting of the temporal region (100%) in patients operated on using a coronal approach; permanent hypoesthesia of V2 (13%) and V1 (8%) in patients operated on with an upper eyelid incision...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734977/parapharyngeal-space-tumours-video-assisted-minimally-invasive-transcervical-approach
#16
F Pilolli, L Giordano, A Galli, M Bussi
The purpose of the present study was to evaluate the advantages of a video-assisted, minimally invasive transcervical approach to benign and malignant parapharyngeal space (PPS) tumours. Ten patients affected by benign and malignant PPS neoplasms underwent a combined transcervical and video-assisted minimally invasive approach, using Hopkins telescopes. We describe the operative technique and perform a review of the literature. Definitive histology revealed 3 pleomorphic adenomas, 2 schwannomas, 2 metastatic papillary thyroid carcinomas, one carcinoma ex pleomorphic adenoma, one cavernous haemangioma and one basal cell adenoma...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734976/human-papillomavirus-and-head-and-neck-carcinomas-focus-on-evidence-in-the-babel-of-published-data
#17
P Morbini, M Benazzo
Human papillomavirus (HPV)-associated squamous cell carcinoma of the oropharynx is a well-defined entity mostly affecting young to middle-aged male non-smokers. It is generally associated with a favourable outcome, and for this reason a less intensive therapeutic approach has been proposed for this subset of patients. The incidence of HPV-associated oropharyngeal cancers is rapidly increasing in most Western countries, but detailed epidemiological data are not available for the Italian population. Furthermore, among other head and neck regions, a smaller proportion of oral high-grade dysplasia and cancers seems to depend on HPV infection, whereas its role in laryngeal cancer is recognised as less relevant...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27214836/further-characterisation-of-the-recently-described-slc26a4-c-918-2t-c-mutation-and-reporting-of-a-novel-variant-predicted-to-be-damaging
#18
A C Gonçalves, R Santos, A O'Neill, P Escada, G Fialho, H Caria
Pendred syndrome (PS) is the second most common type of autosomal recessive syndromic hearing loss (HL). It is characterised by sensorineural HL and goiter with occasional hypothyroidism. These features are generally accompanied by malformations of the inner ear, as enlarged vestibular aqueduct (EVA). In about 50% of probands, mutations in the SLC26A4 gene are the cause of the disease. Here we report the case of a Portuguese female, aged 47, presenting with severe to profound HL and hypothyroidism. Her mother and sister, both deceased, had suffered from HL and goiter...
June 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27214835/considerations-on-endoscopic-endonasal-approach-to-the-craniocervical-junction-the-importance-of-anterior-c1-arch-preservation-or-its-reconstruction
#19
M Visocchi
No abstract text is available yet for this article.
June 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27214834/long-term-surgical-results-in-microvascular-decompression-for-hemifacial-spasm-efficacy-morbidity-and-quality-of-life
#20
M Montava, V Rossi, C L CurtoFais, J Mancini, J-P Lavieille
Hemifacial spasm is a condition that may severely reduce patients' quality of life. Microvascular decompression is the neurosurgical treatment of choice. The objective of this work was to describe the efficacy and morbidity of microvascular decompression for hemifacial spasm, evaluate the long-term efficacy on the quality of life and investigate prognostic factors for failure of the procedure. A retrospective study of 446 cases of hemifacial spasm treated by 511 retrosigmoid microvascular decompression over 22 years was conducted...
June 2016: Acta Otorhinolaryngologica Italica
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