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Acta Otorhinolaryngologica Italica

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https://www.readbyqxmd.com/read/27897275/an-ex-vivo-model-contributing-to-the-diagnosis-and-evaluation-of-new-drugs-in-cystic-fibrosis
#1
A M Di Lullo, M Scorza, F Amato, M Comegna, V Raia, L Maiuri, G Ilardi, E Cantone, G Castaldo, M Iengo
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene. About 2000 mutations have been described so far. We setup an ex vivo model of human nasal epithelial cells (HNECs) to study CF patients testing the effect of novel mutations and molecular therapies. We performed the sampling (by brushing), followed by culture and analysis of HNECs using a series of molecular techniques. We performed 50 brushings from CF patients and controls...
November 29, 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27897274/modelling-tumour-volume-variations-in-head-and-neck-cancer-magnetic-resonance-imaging-contribution-for-patients-undergoing-induction-chemotherapy
#2
N Dinapoli, T Tartaglione, F Bussu, R Autorino, F Miccichè, M Sciandra, E Visconti, C Colosimo, G Paludetti, V Valentini
Primary tumour volume evaluation has predictive value for estimating survival outcomes. Using volumetric data acquired by MRI in patients undergoing induction chemotherapy (IC) these outcomes were estimated before the radiotherapy course in head and neck cancer (HNC) patients. MRI performed before and after IC in 36 locally advanced HNC patients were analysed to measure primary tumour volume. The two volumes were correlated using the linear-log ratio (LLR) between the volume in the first MRI and the volume in the second...
November 29, 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27958603/a-connection-between-neurovascular-conflicts-within-the-cerebellopontine-angle-and-vestibular-neuritis-a-case-controlled-cohort-study
#3
B Loader, I Linauer, S Korkesch, I Krammer-Effenberger, V Zielinski, N Schibany, A Kaider, E Vyskocil, D Tscholakoff, P Franz
This retrospective, observer blinded case-control study aims to compare the prevalence of neurovascular conflicts (NVCs) of the vestibulocochlear nerve and the anterior inferior cerebellar artery (AICA) in patients presenting with clinical signs of acute vestibular neuritis with and without subsequent objective vestibular function loss (VFL). 58 acute cases of clinically suspected acute vestibular neuritis were investigated with same day cranial MRI at a tertiary referral centre and compared to 61 asymptomatic controls...
October 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27958602/severe-to-profound-deafness-may-be-associated-with-myh9-related-disease-report-of-4-patients
#4
P Canzi, A Pecci, M Manfrin, E Rebecchi, C Zaninetti, V Bozzi, M Benazzo
MYH9-related disease (MYH9-RD) is a rare genetic syndromic disorder characterised by congenital thrombocytopenia and is associated with the risk of developing progressive sensorineural hearing loss, nephropathy and presenile cataracts during childhood or adult life. All consecutive patients enrolled in the Italian Registry for MYH9-RD with severe to profound deafness were included in a retrospective study. The study population involved 147 Italian patients with MYH9-RD: hearing loss was identified in 52% of cases and only 4 patients (6%) presented severe to profound deafness at a mean age of 33 years...
October 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27958601/open-partial-horizontal-laryngectomies-is-it-time-to-adopt-a-modular-form-of-consent-for-the-intervention
#5
L Giordano, D Di Santo, E Crosetti, A Bertolin, G Rizzotto, G Succo, M Bussi
Nowadays, open partial horizontal laryngectomies (OPHLs) are well-established procedures for treatment of laryngeal cancer. Their uniqueness is the possibility to modulate the intervention intraoperatively, according to eventual tumour extension. An OPHL procedure is not easy to understand: there are several types of procedures and the possibility to modulate the intervention can produce confusion and lack of adherence to the treatment from the patient. Even if the surgery is tailored to a patient's specific lesion, a unified consent form that discloses any possible extensions, including a total laryngectomy, is still needed...
October 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27958600/comparison-between-videofluoroscopy-fiberoptic-endoscopy-and-scintigraphy-for-diagnosis-of-oro-pharyngeal-dysphagia
#6
B Fattori, P Giusti, V Mancini, M Grosso, M R Barillari, L Bastiani, S Molinaro, A Nacci
The purpose of this study was to compare videofluoroscopy (VFS), fiberoptic endoscopic evaluation of swallowing (FEES) and oro-pharyngo- oesophageal scintigraphy (OPES) with regards to premature spillage, post-swallowing residue and aspiration to assess the reliability of these tests for detection of oro-pharyngeal dysphagia. Sixty patients affected with dysphagia of various origin were enrolled in the study and submitted to VFS, FEES and OPES using a liquid and semi-solid bolus. As a reference, we used VFS...
October 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27958599/association-between-oral-habits-mouth-breathing-and-malocclusion
#7
C Grippaudo, E G Paolantonio, G Antonini, R Saulle, G La Torre, R Deli
The ratio of bad habits, mouth breathing and malocclusion is an important issue in view of prevention and early treatment of disorders of the craniofacial growth. While bad habits can interfere with the position of the teeth and normal pattern of skeletal growth, on the other hand obstruction of the upper airway, resulting in mouth breathing, changes the pattern of craniofacial growth causing malocclusion. Our crosssectional study, carried out on 3017 children using the ROMA index, was developed to verify if there was a significant correlation between bad habits/mouth breathing and malocclusion...
October 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27958598/advanced-oxidation-protein-product-levels-as-a-marker-of-oxidative-stress-in-paediatric-patients-with-chronic-tonsillitis
#8
I Ozbay, C Kucur, F E Koçak, B Savran, F Oghan
We aimed to determine whether advanced oxidation protein product (AOPP) levels can serve as a marker of oxidative stress in paediatric patients with chronic tonsillitis. Thirty children with chronic tonsillitis and 30 healthy children (control group) were recruited from the Otorhinolaryngology (ORL) and Paediatric Surgery departments, respectively, of Dumlupinar University Hospital. In the patient group, blood samples were collected before tonsillectomy, and tonsil tissue was sampled during the operation. Blood samples were also obtained from the control subjects...
October 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27958597/salvage-total-laryngectomy-after-conservation-laryngeal-surgery-for-recurrent-laryngeal-squamous-cell-carcinoma
#9
A De Virgilio, A Greco, F Bussu, A Gallo, D Rosati, S-H Kim, C-C Wang, M Conte, G Pagliuca, M De Vincentiis
The aim of the present study was to evaluate the oncological efficacy of salvage total laryngectomy in patients who had previously undergone supracricoid partial laryngectomy or transoral laser microsurgery for treatment of laryngeal squamous cell carcinoma. We retrospectively reviewed the medical, surgical and pathological records of 35 patients who underwent salvage total laryngectomy after recurrence of laryngeal cancer (following supracricoid partial laryngectomy or transoral laser microsurgery). Kaplan-Meier survival curves as well as univariate and multivariate analyses of prognostic factors were performed...
October 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27958596/lipofilling-as-refinement-procedure-in-maxillo-mandibular-malformations
#10
D Cervelli, G Gasparini, A Moro, S Pelo, E Foresta, F Grussu, G D'Amato, P De Angelis, G Saponaro
Maxillo-mandibular asymmetry has numerous aetiologies: congenital, traumatic, iatrogenic and post-oncologic. Patients with congenital dentofacial malformations are generally submitted to orthognathic surgery and/or additional procedures (genioplasty, alloplastic implants) with satisfactory results. However, despite achieving skeletal symmetry, noticeable facial asymmetry may persist.This study was performed in 45 patients (29 women and 16 men) operated between December 2012 and June 2014. All patients were affected by maxilla-mandibular asymmetry and underwent orthognatic surgery for hard tissue correction of the deformity...
October 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27958595/childhood-neurofibromatosis-type-2-nf2-and-related-disorders-from-bench-to-bedside-and-biologically-targeted-therapies
#11
M Ruggieri, A D Praticò, A Serra, L Maiolino, S Cocuzza, P Di Mauro, L Licciardello, P Milone, G Privitera, G Belfiore, M Di Pietro, F Di Raimondo, A Romano, A Chiarenza, M Muglia, A Polizzi, D G Evans
Neurofibromatosis type 2 [NF2; MIM # 101000] is an autosomal dominant disorder characterised by the occurrence of vestibular schwannomas (VSs), schwannomas of other cranial, spinal and cutaneous nerves, cranial and spinal meningiomas and/or other central nervous system (CNS) tumours (e.g., ependymomas, astrocytomas). Additional features include early onset cataracts, optic nerve sheath meningiomas, retinal hamartomas, dermal schwannomas (i.e., NF2-plaques), and (few) café-au-lait spots. Clinically, NF2 children fall into two main groups: (1) congenital NF2 - with bilateral VSs detected as early as the first days to months of life, which can be stable/asymptomatic for one-two decades and suddenly progress; and (2) severe pre-pubertal (Wishart type) NF2- with multiple (and rapidly progressive) CNS tumours other-than-VS, which usually present first, years before VSs [vs...
October 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27600105/surgical-treatment-of-sporadic-vestibular-schwannoma-in-a-series-of-1006-patients
#12
Z Zhang, Y Nguyen, D De Seta, F Y Russo, A Rey, M Kalamarides, O Sterkers, D Bernardeschi
The management of sporadic vestibular schwannoma (VS) has evolved in the last decades. The aim of this study was to analyse the evolution in surgical outcomes of VSs operated by a neurotological team between 1990 and 2006 by different approaches. A monocentric retrospective review of medical charts of 1006 patients was performed. In order to assess eventual changes and progress, the 17-years period was divided in three periods, each one comprehending 268 VS (1990-1996), 299 VS (1997-2001), and 439 VS (2002-2006)...
October 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27070537/cochlear-implantation-in-delayed-sudden-hearing-loss-after-conservative-vestibular-schwannoma-surgery
#13
F Dagna, A Murri, R Albera, D Cuda
This is a case of successful cochlear implantation in a 50-year-old man who experienced sudden hearing loss and developed ipsilateral severe tinnitus at three years following conservative stage 1 vestibular schwannoma retrosigmoid surgery. After cochlear implantation, tinnitus improved from THI grade 4 to 2. Localisation skills improved. Hearing in noise (S/N + 7 dB) with target signal from the operated side improved from 38 to 100% of correct answers. A significant improvement of spatial and speech items of the "speech, spatial and qualities of sounds" questionnaire was also measured...
October 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27070536/anterior-laryngofissure-approach-in-type-iii-laryngotracheal-cleft-a-case-report
#14
A E Arslankoylu, E Unal, N Kuyucu, O Ismi
Laryngeal and laryngotracheal clefts are rare congenital malformations of the laryngobronchial tree. Their symptoms vary from mild cough to life threatening pulmonary aspiration and cyanosis. Type I and II clefts can be observed without surgical intervention, whereas type III and IV clefts usually require an anterior or lateral cervical approach. We present a case of type III laryngotracheal cleft seen in a 3-monthold male infant who died during revision surgery after an anterior laryngofissure approach. We discuss the difficulties in diagnosis, management and importance of anaesthesia for these rare anomalies in light of the current literature...
October 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27600104/3d-curved-multiplanar-cone-beam-ct-reconstruction-for-intracochlear-position-assessment-of-straight-electrodes-array-a-temporal-bone-and-clinical-study
#15
D De Seta, P Mancini, F Y Russo, R Torres, I Mosnier, J L Bensimon, E De Seta, D Heymann, O Sterkers, D Bernardeschi, Y Nguyen
A retrospective review of post-op cone beam CT (CBCT) of 8 adult patients and 14 fresh temporal bones that underwent cochlear implantation with straight flexible electrodes array was performed to determine if the position of a long and flexible electrodes array within the cochlear scalae could be reliably assessed with CBCT. An oto-radiologist and two otologists examined the images and assessed the electrodes position. The temporal bone specimens underwent histological analysis for confirm the exact position...
September 6, 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734988/arterio-venous-malformation-of-the-mandible-case-report-and-review-of-literature
#16
R Spreafico, L Sordo, R Bellotto, M Schipano, A Rescaldani, F Parmigiani
Arteriovenous malformation (AVM) of the head and neck is a rare and potentially life threatening entity due to massive haemorrhage. There are several indications for treatment, including age of the patient and location, extent and type of vascular malformation. Endovascular therapy can effectively cure most lesions with limited tissue involvement. Surgery can be used in selected cases in combination with embolization. Here we report the case of a young woman affected by a massive AVM on the left side of the mandible and submandibular region, and also review the literature on AVM with special attention to treatment strategies...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734987/the-relevance-of-counseling-in-patients-with-nasal-polyps
#17
M Gelardi, N De Candia, N Quaranta, C Russo, P Pecoraro, M Mancini, P Luperto, G Lombardo, A Macchi, C Bocciolini, A Ciofalo, E De Corso, G Ciprandi
No abstract text is available yet for this article.
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734986/vastus-lateralis-myofascial-free-flap-in-tongue-reconstruction
#18
R Pellini, A De Virgilio, G Mercante, B Pichi, V Manciocco, P Marchesi, F Ferreli, G Spriano
In the last decade, the antero-lateral thigh free flap (ALT) has become the most popular free flap for tongue reconstruction because of less donor site morbidity and better cosmetic outcomes. However, fascio-cutaneous ALT may be insufficient to reconstruct major tongue defects, while its muscular-cutaneous variant (using the vastus lateralis muscle) may be too bulky. The present study describes our preliminary experience of tongue reconstruction with vastus lateralis myofascial flap, which could potentially offer unique advantages in head and neck reconstruction including adequate bulk when needed, optimal functional results and obliteration of dead space thus preventing fistulas and infections with minimal morbidity...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734985/prevention-of-bisphosphonate-related-mandibular-fractures
#19
M Pedrazzoli, L Autelitano, F Biglioli
Mandibular fracture is usually the clinical end of bisphosphonate-related osteonecrosis of the jaw. This is a painful complication and patients cannot feed as usual, with a worsening of their quality of life. The goal of treatment in bisphosphonate related osteonecrosis of jaw (BRONJ) patients is to slow progression of bone necrosis. We present a novel technique for treatment of severe mandibular BRONJ in stage 3 patients that present with a high risk to develop fracture, since they have a residual unaffected mandibular bone height less than 6 mm...
August 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/27734984/possibility-of-differentiation-of-cochlear-electrodes-in-radiological-measurements-of-the-intracochlear-and-chorda-facial-angle-position
#20
I Diogo, U Walliczeck, J Taube, N Franke, A Teymoortash, J Werner, C Güldner
Due to an increasing number of cochlear implantations, quality control has become more important. In addition to intraoperative biophysical measurements, radiological imaging is another possibility. An upcoming technique regarding this is Cone Beam CT (CBCT). Sixty-five data sets (35 Nucleus Contour Advance-Cochlear; 30 Flex Soft-MedEl) of postoperative imaging by CBCT (Accu-I-tomo F17, Morita, Kyoto, Japan) underwent further evaluation. Insertion angle, height of the cochlea, distance of the electrode to the medial or lateral wall, angle between chorda tympani and facial nerve and the precise position of the electrode cable in the facial-chordal angle were determined...
August 2016: Acta Otorhinolaryngologica Italica
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