Julia Canzian, João V Borba, Jaíne Ames, Rossano M Silva, Cássio M Resmim, Camilla W Pretzel, Maria Cecília F Duarte, Tamiris R Storck, Khadija A Mohammed, Isaac A Adedara, Vania L Loro, Robert Gerlai, Denis B Rosemberg
Functional changes in dopamine transporter (DAT) are related to various psychiatric conditions, including bipolar disorder (BD) symptoms. In experimental research, the inhibition of DAT induces behavioral alterations that recapitulate symptoms found in BD patients, including mania and depressive mood. Thus, developing novel animal models that mimic BD-related conditions by pharmacologically modulating the dopaminergic signaling is relevant. The zebrafish (Danio rerio) has been considered a suitable vertebrate system for modeling BD-like responses, due to the well-characterized behavioral responses and evolutionarily conservation of the dopaminergic system of this species...
February 5, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry