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Progress in Neuro-psychopharmacology & Biological Psychiatry

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https://www.readbyqxmd.com/read/28192174/does-genetic-bdnf-deficiency-in-rats-interact-with-neurotransmitter-control-of-prepulse-inhibition-implications-for-schizophrenia
#1
Maarten van den Buuse, Davina Biel, Kathrin Radscheit
Several studies have suggested a role of BDNF in the development of schizophrenia. For example, post-mortem studies have shown significantly reduced levels of BDNF protein expression in the brain of schizophrenia patients. We investigated the relationship between reduced levels of BDNF in the brain and the regulation of prepulse inhibition (PPI), a behavioral endophenotype of schizophrenia. We used BDNF heterozygous mutant rats which display a 50% decrease of mature BDNF protein levels. Previously, we observed normal baseline PPI and responses to the dopamine D1/D2 receptor agonist, apomorphine, in these rats...
February 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28189704/role-of-infiltrating-monocytes-macrophages-in-acute-and-chronic-neuroinflammation-effects-on-cognition-learning-and-affective-behaviour
#2
Aedín M Minogue
Peripheral macrophages have limited capacity to gain access to the brain parenchyma under normal physiological conditions. However, accumulating evidence indicates that significant trafficking to the central nervous systems occurs in response to injury or infection and is also apparent under chronic neuroinflammatory conditions. The role of infiltrating macrophages in neuronal function is unclear and confounded by the similarity in morphology and phenotype adopted by both activated macrophages and microglia...
February 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28188811/day-night-changes-in-serum-s100b-protein-concentrations-in-acute-paranoid-schizophrenia
#3
Armando L Morera-Fumero, Estefanía Díaz-Mesa, Pedro Abreu-Gonzalez, Lourdes Fernandez-Lopez, Maria Del Rosario Cejas-Mendez
No abstract text is available yet for this article.
February 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28185964/experimental-occlusal-disharmony-a-promoting-factor-for-anxiety-in-rats-under-chronic-psychological-stress
#4
Xuan Tang, Jian Li, Ting Jiang, Shu-Hui Han, Dong-Yuan Yao
BACKGROUND AND PURPOSE: Clinically, patients under chronic psychological stress (PS) appear to be more susceptible to occlusal disharmony (OD) compared with those without PS. OD was proved to introduce anxiety-like stress. Therefore, the purpose of the study was to investigate whether OD would affect psychological stress-induced anxiety and its underlying mechanisms. METHODS: Chronic PS was induced by a communication box, and OD was produced by bonding a 0.3mm-thick crown on the right maxillary first molar of male Sprague-Dawley rats...
February 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28185965/cav1-2-but-not-cav1-3-l-type-calcium-channel-subtype-mediates-nicotine-induced-conditioned-place-preference-in-miceo
#5
Yudan Liu, Meghan Harding, Jules Dore, Xihua Chen
Nicotine use is one of the most common forms of drug addiction. Although L-type calcium channels (LTCCs) are involved in nicotine addiction, the contribution of the two primary LTCC subtypes (Cav1.2 and 1.3) is unknown. This study aims to determine the contribution of these two LTCC subtypes to nicotine-induced conditioned place preference (CPP) responses by using transgenic mouse models that do not express Cav1.3 (Cav1.3(-/-)) or contain a mutation in the dihydropyridine (DHP) site of the Cav1.2 (Cav1.2DHP(-/-))...
February 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28185963/increased-network-centrality-as-markers-of-relapse-risk-in-nicotine-dependent-individuals-treated-with-varenicline
#6
Zhujing Shen, Peiyu Huang, Chao Wang, Wei Qian, Yihong Yang, Minming Zhang
Identifying smokers at high risk of relapse could improve the effectiveness of cessation therapies. Although altered regional brain function in smokers has been reported, whether the whole-brain functional organization differs smokers with relapse vulnerability from others remains unclear. Thus, the goal of this study is to investigate the baseline functional connectivity differences between relapsers and quitters. Using resting-state fMRI, we acquired images from 57 smokers prior to quitting attempts. After 12-week treatment with varenicline, smokers were divided into relapsers (n=36) and quitters (n=21) (quitter: continuously abstinent for weeks 9-12)...
February 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28174127/altered-functional-connectivity-in-default-mode-network-in-internet-gaming-disorder-influence-of-childhood-adhd
#7
Deokjong Lee, Junghan Lee, Jung Eun Lee, Young-Chul Jung
OBJECTIVE: Internet gaming disorder (IGD) is a type of behavioral addiction characterized by abnormal executive control, leading to loss of control over excessive gaming. Attention deficit and hyperactivity disorder (ADHD) is one of the most common comorbid disorders in IGD, involving delayed development of the executive control system, which could predispose individuals to gaming addiction. We investigated the influence of childhood ADHD on neural network features of IGD. METHODS: Resting-state functional magnetic resonance imaging analysis was performed on 44 young, male IGD subjects with and without childhood ADHD and 19 age-matched, healthy male controls...
February 5, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28174129/intrinsic-cerebral-activity-at-resting-state-in-adults-with-major-depressive-disorder-a-meta-analysis
#8
Ming Zhou, Xinyu Hu, Lu Lu, Lianqing Zhang, Lizhou Chen, Qiyong Gong, Xiaoqi Huang
Numerous neuroimaging studies have been undertaken to detect cerebral intrinsic activity in major depressive disorder (MDD) with resting state fMRI (rs-fMRI). However, the inconsistent results have hindered our understanding of the exact neuropathology related to MDD. The current meta-analysis used state-of-the-art conjunction analysis techniques to systematically review and summarize all available neuroimaging studies using rs-fMRI with amplitude of low frequency fluctuation (ALFF) and/or fractional ALFF (fALFF) on MDD patients and further explored the effect of antidepressants on the intrinsic activity of the brain...
February 4, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28174128/intervention-timing-is-important-to-the-effects-of-antipsychotics-in-adjusting-abnormalities-of-gating-function-but-not-accumbal-dopamine-efflux-in-isolation-reared-rats
#9
Yia-Ping Liu, Yu-Yin Yang, Fang-Jung Wan, Che-Se Tung
Early pharmacological treatment is a dilemma for psychiatrist in treating young schizophrenic patients. However, based on developmental theory, earlier antipsychotic intervention could be beneficial in terms of protecting the neurons from further deterioration. The present study aims to examine whether the intervention of second-generation antipsychotics (SGAs) launched at a younger age would provide a better index in amending the schizophrenia-relevant behavioral and neurochemical features, namely acoustic prepulse inhibition (PPI) and midbrain dopamine efflux, respectively...
February 4, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28159590/pharmacogenetics-of-antidepressant-response-a-polygenic-approach
#10
Judit García-González, Katherine E Tansey, Joanna Hauser, Neven Henigsberg, Wolfgang Maier, Ole Mors, Anna Placentino, Marcella Rietschel, Daniel Souery, Tina Žagar, Piotr M Czerski, Borut Jerman, Henriette N Buttenschøn, Thomas G Schulze, Astrid Zobel, Anne Farmer, Katherine J Aitchison, Ian Craig, Peter McGuffin, Michel Giupponi, Nader Perroud, Guido Bondolfi, David Evans, Michael O'Donovan, Tim J Peters, Jens R Wendland, Glyn Lewis, Shitij Kapur, Roy Perlis, Volker Arolt, Katharina Domschke, Gerome Breen, Charles Curtis, Lee Sang-Hyuk, Carol Kan, Stephen Newhouse, Hamel Patel, Bernhard T Baune, Rudolf Uher, Cathryn M Lewis, Chiara Fabbri
BACKGROUND: Major depressive disorder (MDD) has a high personal and socio-economic burden and >60% of patients fail to achieve remission with the first antidepressant. The biological mechanisms behind antidepressant response are only partially known but genetic factors play a relevant role. A combined predictor across genetic variants may be useful to investigate this complex trait. METHODS: Polygenic risk scores (PRS) were used to estimate multi-allelic contribution to: 1) antidepressant efficacy; 2) its overlap with MDD and schizophrenia...
January 31, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28153806/a-study-of-brain-metabolism-in-fibromyalgia-by-positron-emission-tomography
#11
Chie Usui, Tsutomu Soma, Kotaro Hatta, Satoko Aratani, Hidetoshi Fujita, Kenya Nishioka, Yutaka Machida, Yoshiyuki Kuroiwa, Toshihiro Nakajima, Kusuki Nishioka
PURPOSE: The aim of the present study was to determine the brain regions with altered metabolism in patients with treatment-naïve fibromyalgia (FM). METHODS: We used [(18)F] fluoro-d-glucose positron emission tomography to examine a total of 18 treatment-naïve FM patients and 18 age- and sex-matched healthy controls not suffering from pain. A voxel-by-voxel group analysis was performed using statistical parametric mapping. RESULTS: No significant voxel (peak)-level results were detected in this study; however, some regions were detected as significant-size clusters...
January 30, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28137432/higher-than-recommended-dosages-of-antipsychotics-in-male-patients-with-schizophrenia-are-associated-with-increased-depression-but-no-major-neurocognitive-side-effects-results-of-a-cross-sectional-pilot-naturalistic-study
#12
Konstantinos N Fountoulakis, Xenia Gonda, Melina Siamouli, Katerina Moutou, Zoe Nitsa, Brian E Leonard, Siegfried Kasper
INTRODUCTION: The current small pilot naturalistic cross-sectional study assesses whether higher dosages of antipsychotics are related to a satisfactory outcome concerning symptoms of schizophrenia but also to a worse outcome in terms of adverse events and neurocognitive function. MATERIAL AND METHODS: 41 male stabilized hospitalized schizophrenic patients were assessed by PANSS, Calgary Depression Rating Scale, UKU and Simpson-Angus Scale and a battery of neurocognitive tests...
January 28, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28132777/reduced-muscle-mass-in-middle-aged-depressed-patients-is-associated-with-male-gender-and-chronicity
#13
Kai G Kahl, Ferdi Utanir, Ulrich Schweiger, Tillmann H Krüger, Helge Frieling, Stefan Bleich, Marcel Gutberlet, Dagmar Hartung
OBJECTIVE: Reduced muscle mass is a characteristic finding in sarcopenia, the central element of physical frailty syndrome, and a major cause of physical function decay, morbidity and mortality in the elderly. Studies so far demonstrated reduced muscle mass in depressed patients with an average age over 60years.An open question is whether muscle mass reduction is already observed earlier. Therefore, muscle mass was assessed in middle-aged male and female depressive patients, and the findings were related to indicators of hypothalamus-pituitary adrenal axis activation, lifestyle factors, endocrine and immune measures...
January 26, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28126372/emotion-regulation-related-neural-predictors-of-cognitive-behavioral-therapy-response-in-social-anxiety-disorder
#14
Heide Klumpp, Julia Roberts, Amy E Kennedy, Stewart A Shankman, Scott A Langenecker, James J Gross, Luan K Phan
Social anxiety disorder (SAD) is characterized by aberrant prefrontal activity during reappraisal, an adaptive cognitive approach aimed at downregulating the automatic response evoked by a negative event. Cognitive behavioral therapy (CBT) is first-line psychotherapy for SAD, however, many remain symptomatic after treatment indicating baseline individual differences in neurofunctional activity may factor into CBT outcome. An emotion regulation strategy practiced in CBT is cognitive restructuring, a proxy for reappraisal...
January 24, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28111292/disruption-of-brain-mek-erk-sequential-phosphorylation-and-activation-during-midazolam-induced-hypnosis-in-mice-roles-of-gabaa-receptor-mek1-inactivation-and-phosphatase-mkp-3
#15
María Álvaro-Bartolomé, Glòria Salort, Jesús A García-Sevilla
Midazolam is a positive allosteric modulator at GABAA receptor that induces a short hypnosis and neuroplasticity, in which the sequential phosphorylation of MEK1/2 and ERK1/2 was shown to play a role. This study investigated the parallel activation of p-MEK and p-ERK and regulatory mechanisms induced by midazolam through the stimulation of GABAA receptors in the mouse brain. During the time course of midazolam (60mg/kg)-induced sleep in mice (lasting for about 2h) p-Ser217/221 MEK1/2 was increased (+146% to +258%) whereas, unexpectedly, p-Tyr204/Thr202 ERK1/2 was found decreased (-16% to -38%), revealing uncoupling of MEK to ERK signals in various brain regions...
January 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28110862/corrigendum-to-hallucinatory-experience-as-aberrant-event-memory-formation-implications-for-the-pathophysiology-of-schizophrenia-prog-neuro-psychopharmacol-biol-psychiatry-71-2016-203-209
#16
Ralf-Peter Behrendt
No abstract text is available yet for this article.
January 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28093220/increased-oxytocin-levels-among-abstinent-heroin-addicts-association-with-aggressiveness-psychiatric-symptoms-and-perceived-childhood-neglect
#17
Lidia M Gerra, Gilberto Gerra, Laura Mercolini, Matteo Manfredini, Lorenzo Somaini, Chiara M Pieri, Maina Antonioni, Michele Protti, Paolo Ossola, Carlo Marchesi
A disruption of the oxytocin system seems to affect a variety of brain functions including emotions, mood and social behavior possibly underlying severe social deficits and susceptibility for substance use and mental health disorders. Early life adversity, such as insecure attachment in childhood, has been suggested to influence oxytocin tone contributing to a condition of neurobiological vulnerability. Aim of the present study was to investigate oxytocin serum levels in abstinent heroin addicted patients, in comparison with healthy controls, and the possible correlation with co-occurring psychiatric symptoms, aggressiveness and perception of parental neglect...
January 16, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28095309/microglia-under-psychosocial-stressors-along-the-aging-trajectory-consequences-on-neuronal-circuits-behavior-and-brain-diseases
#18
Li Tian, Chin Wai Hui, Kanchan Bisht, Yunlong Tan, Kaushik Sharma, Song Chen, Xiangyang Zhang, Marie-Eve Tremblay
Mounting evidence indicates the importance of microglia for proper brain development and function, as well as in complex stress-related neuropsychiatric disorders and cognitive decline along the aging trajectory. Considering that microglia are resident immune cells of the brain, a homeostatic maintenance of their effector functions that impact neuronal circuitry, such as phagocytosis and secretion of inflammatory factors, is critical to prevent the onset and progression of these pathological conditions. However, the molecular mechanisms by which microglial functions can be properly regulated under healthy and pathological conditions are still largely unknown...
January 15, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28095308/lithium-induced-malaise-does-not-interfere-with-adaptation-of-the-hypothalamic-pituitary-adrenal-axis-to-stress
#19
Maria Sanchís-Ollé, Juan A Ortega-Sánchez, Xavier Belda, Humberto Gagliano, Roser Nadal, Antonio Armario
We have recently demonstrated that adaptation of the hypothalamic-pituitary-adrenal (HPA) axis to repeated exposure to a stressor does not follow the rules of habituation and can be fully expressed after a single experience with severe stressors. In the present work we tested the hypothesis that adaptation could be impaired if animals experience malaise during initial exposure to the stressor. To this end, animals were allowed to drink saccharin for 30min before being exposed for 3h to immobilization on boards (IMO), a severe stressor; then they were given either saline or lithium ip after the first hour of IMO...
January 15, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28089695/the-pharmacology-of-tacrine-at-n-methyl-d-aspartate-receptors
#20
REVIEW
Martin Horak, Kristina Holubova, Eugenie Nepovimova, Jan Krusek, Martina Kaniakova, Jan Korabecny, Ladislav Vyklicky, Kamil Kuca, Ales Stuchlik, Jan Ricny, Karel Vales, Ondrej Soukup
The mechanism of tacrine as a precognitive drug has been considered to be complex and not fully understood. It has been reported to involve a wide spectrum of targets involving cholinergic, gabaergic, nitrinergic and glutamatergic pathways. Here, we review the effect of tacrine and its derivatives on the NMDA receptors (NMDAR) with a focus on the mechanism of action and biological consequences related to the Alzheimer's disease treatment. Our findings indicate that effect of tacrine on glutamatergic neurons is both direct and indirect...
January 13, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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