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Progress in Neuro-psychopharmacology & Biological Psychiatry

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https://www.readbyqxmd.com/read/29146474/a-systematic-review-and-meta-analysis-of-deep-brain-stimulation-in-treatment-resistant-depression
#1
Chanjuan Zhou, Hanping Zhang, Yinhua Qin, Tian Tian, Bing Xu, Jianjun Chen, Xinyu Zhou, Li Zeng, Liang Fang, Xunzhong Qi, Bin Lian, Haiyang Wang, Zicheng Hu, Peng Xie
BACKGROUND: Deep brain stimulation (DBS) has been applied in treatment-resistant depression (TRD) as a putative intervention targeting different brain regions. However, the antidepressant effects of DBS for TRD in recent clinical trials remain controversial. METHODS: We searched Scopus, EMBASE, the Cochrane Library, PubMed, and PsycINFO for all published studies investigating the efficacy of DBS in TRD up to Feb 2017. Hamilton depression rating scale (HDRS) scores and Montgomery-Asberg depression rating scale (MARDS) scores were compared between baseline levels and those after DBS using the standardized mean difference (SMD) with 95% confidence intervals (CIs)...
November 13, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29146473/estrogen-levels-emotion-regulation-and-emotional-symptoms-of-women-with-premenstrual-dysphoric-disorder-the-moderating-effect-of-estrogen-receptor-1%C3%AE-polymorphism
#2
Ju-Yu Yen, Peng-Wei Wang, Chen-Hsiang Su, Tai-Ling Liu, Cheng-Yu Long, Chih-Hung Ko
BACKGROUND: This study evaluated the association between estrogen levels, emotion regulation, depression, anxiety, and stress of women with premenstrual dysphoric disorder (PMDD). We also evaluated the moderating effect of estrogen receptor (ESR) α-Xbal polymorphism on the aforementioned association. METHODS: A total of 100 women were diagnosed with PMDD based on psychiatric interviews and a prospective investigation of 3 menstrual cycles. A total of 96 normal individuals were recruited as controls...
November 13, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29129723/neural-correlates-of-impaired-self-regulation-in-male-youths-with-autism-spectrum-disorder-a-voxel-based-morphometry-study
#3
Hsing-Chang Ni, Hsiang-Yuan Lin, Wen-Yih Isaac Tseng, Yen-Nan Chiu, Yu-Yu Wu, Wen-Che Tsai, Susan Shur-Fen Gau
Although recent studies revealed impaired self-regulation (dysregulation) in autism spectrum disorder (ASD), neural correlates of dysregulation and its impacts on autistic neuroanatomy remain unclear. Voxel-based morphometry was applied on structural MRI images in 81 ASD and 61 typically developing (TD) boys aged 7-17years. Dysregulation was defined by the sum of T-scores of Attention, Aggression, and Anxiety/Depression subscales in the Child Behavior Checklist>180. There were 53 and 28 boys in the ASD+Dysregulation and ASD-Dysregulation groups, respectively...
November 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29129722/an-extended-history-of-drug-self-administration-results-in-multiple-sources-of-control-over-drug-seeking-behavior
#4
REVIEW
Kelly J Clemens, Nathan M Holmes
It is widely recognized that across the development of drug addiction, cues associated with drug use come to exert increasing control over drug seeking and taking behaviors. However, there remain gaps in our knowledge regarding how the different types of drug related cues affect drug seeking and taking behaviors, and how the emergence of cue control over these behaviors relates to the onset of drug seeking compulsions. This paper reviews the literature on drug self-administration in animals to address these gaps...
November 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29128447/developmental-perspectives-on-methamphetamine-abuse-exploring-adolescent-vulnerabilities-on-brain-and-behavior
#5
REVIEW
Sophia J Luikinga, Jee Hyun Kim, Christina J Perry
Most people that experience illicit drugs do so for the first time during adolescence, and methamphetamine (meth) is no exception. Therefore, research into the effects of meth should highlight the adolescent period. Despite this, the vast majority of current literature has mainly focused on meth exposure during adulthood. In this review, we first describe existing literature that compares the behavioral effects of meth where exposure occurs in adolescence compared to adulthood. Given that there are actually very few such studies, we also look at what is known about neural effects of meth in the adult brain, and relate these to normal neural development occurring during the adolescent period to establish how meth may target maturing regions and related neurochemistry...
November 8, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29128446/disrupted-focal-white-matter-integrity-in-autism-spectrum-disorder-a-voxel-based-meta-analysis-of-diffusion-tensor-imaging-studies
#6
Xin Di, Azeezat Azeez, Xiaobo Li, Emad Haque, Bharat B Biswal
BACKGROUND: Autism spectrum disorder (ASD) is a mental disorder that has long been considered to result from brain underconnectivity. However, volumetric analysis of structural MRI data has failed to find consistent white matter alterations in patients with ASD. The present study aims to examine whether there are consistent focal white matter alterations as measured by diffusion tensor imaging (DTI) in individuals with ASD compared with typically developing (TD) individuals. METHOD: Coordinate-based meta-analysis was performed on 14 studies that reported fractional anisotropy (FA) alterations between individuals with ASD and TD individuals...
November 8, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29128445/the-promise-of-induced-pluripotent-stem-cells-for-neurodevelopmental-disorders
#7
REVIEW
Katrin Linda, Carol Fiuza, Nael Nadif Kasri
A major challenge in clinical genetics and medicine is represented by genetically and phenotypically highly diverse neurodevelopmental disorders, like for example intellectual disability and autism. Intellectual disability is characterized by substantial limitations in cognitive function and adaptive behaviour. At the cellular level, this is reflected by deficits in synaptic structure and plasticity and therefore has been coined as a synaptic disorder or "synaptopathy". In this review, we summarize the findings from recent studies in which iPSCs have been used to model specific neurodevelopmental syndromes, including Fragile X syndrome, Rett syndrome, Williams-Beuren syndrome and Phelan-McDermid syndrome...
November 8, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29126982/effects-of-chronic-social-defeat-on-social-behaviors-in-adult-female-mandarin-voles-microtus-mandarinus-involvement-of-the-oxytocin-system-in-the-nucleus-accumbens
#8
Limin Wang, Wenjuan Hou, Zhixiong He, Wei Yuan, Jinfeng Yang, Yang Yang, Rui Jia, Zhenxiang Zhu, Yue Zhou, Fadao Tai
Chronic social defeat affects many aspects of behavior. Most previous studies have focused on effects on males and defeat during adolescence. The extents to which chronic social defeat can impact female social behavior in adulthood and the neural mechanisms of such effects are poorly understood. Using highly social and aggressive female mandarin voles (Microtus mandarinus), the present study found that chronic social defeat reduced social preference in adult females, and that the defeated voles exhibited a high level of freeze, self-grooming and defensive behavior, as well as reduced exploration, intimacy and aggression during social interactions...
November 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29126981/therapeutic-effect-of-adjunctive-n-acetyl-cysteine-nac-on-symptoms-of-chronic-schizophrenia-a-double-blind-randomized-clinical-trial
#9
Zahra Sepehrmanesh, Mahsa Heidary, Negar Akasheh, Hossein Akbari, Mahshid Heidary
BACKGROUND: Schizophrenia is one of the most disabling psychiatric syndromes with the prevalence of 1% in the general population. Despite availability of various antipsychotics, negative symptoms and cognitive impairment are difficult to treat. In addition antipsychotic monotherapy is not effective in most of these patients. Current evidence indicates the roles of glutamatergic system in this disorder. N-acetyl cysteine (NAC) also increases extracellular glutamate. This study was conducted to evaluate the clinical effects of oral NAC as an add-on to maintenance medication for the treatment of chronic schizophrenia...
November 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29126980/brain-derived-neurotrophic-factor-in-adjuvant-induced-arthritis-in-rats-relationship-with-inflammation-and-endothelial-dysfunction
#10
Martin Pedard, Céline Demougeot, Clément Prati, Christine Marie
OBJECTIVES: Both peripheral and central brain-derived neurotrophic factor (BDNF) levels are decreased in depression and normalized by efficient anti-depressive therapies. While depression symptoms are frequent in rheumatoid arthritis, BDNF has been poorly investigated in this pathology. Therefore, the present study explored cerebral and peripheral BDNF in arthritis rats as well as the link between brain BDNF and the two factors recently involved in the pathogenesis of depression and present in rheumatoid arthritis namely inflammation and endothelial dysfunction...
November 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29122639/the-p2rx7-polymorphism-rs2230912-is-associated-with-depression-a-meta-analysis
#11
D Czamara, B Müller-Myhsok, S Lucae
Various studies have investigated whether single nucleotide polymorphisms (SNPs) in the gene purinergic receptor P2X7 (P2RX7), and rs2230912 specifically, were associated with mood disorders. While some studies found positive evidence, a large number of studies reported no significant associations. In a previously published meta-analysis, Feng et al. did not find a significant association and only moderate odds ratios (ORs) in case-control studies. They reported significant findings only for family-based studies...
November 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29122638/neural-indices-of-emotional-reactivity-and-regulation-predict-course-of-ptsd-symptoms-in-combat-exposed-veterans
#12
Jacklynn M Fitzgerald, Stephanie M Gorka, Autumn Kujawa, Julia A DiGangi, Eric Proescher, Justin E Greenstein, Darrin M Aase, Christopher Schroth, Kaveh Afshar, Amy E Kennedy, Greg Hajcak, K Luan Phan
After diagnosis, veterans with posttraumatic stress disorder (PTSD) display significant variability in the natural course of illness (Bonanno et al., 2012)). Cross-sectional work reveals that abnormal neural response during emotion reactivity-measured using the late positive potential (LPP)-correlates with PTSD symptom severity; however, whether the LPP during emotional reactivity and regulation predicts symptoms over time is unknown. The current study examined the LPP during emotion reactivity and regulation as predictors of PTSD symptoms over one year in OEF/OIF/OND combat-exposed veterans...
November 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29122637/side-effect-burden-of-antipsychotic-drugs-in-real-life-impact-of-gender-and-polypharmacy
#13
Trude Seselie Jahr Iversen, Nils Eiel Steen, Ingrid Dieset, Sigrun Hope, Ragni Mørch, Erlend Strand Gardsjord, Kjetil Nordbø Jørgensen, Ingrid Melle, Ole A Andreassen, Espen Molden, Erik G Jönsson
BACKGROUND: Antipsychotic-associated side effects are well known and represent a significant treatment challenge. Still, few large studies have investigated the overall side effect burden of antipsychotics in real-life settings. OBJECTIVE: To describe the occurrence of side effects and perceived burden of antipsychotics in a large naturalistic sample, taking polypharmacy and patient characteristics into account. METHOD: Patients (n=1087) with psychotic disorders were assessed for side effects using the Udvalg for Kliniske Undersøgelser (UKU) side effect rating scale in addition to assessment of clinical and pharmacological data...
November 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29100975/personality-measures-after-gamma-ventral-capsulotomy-in-intractable-ocd
#14
Raquel R Paiva, Marcelo C Batistuzzo, Nicole C McLaughlin, Miguel M Canteras, Maria E de Mathis, Guaraci Requena, Roseli G Shavitt, Benjamin D Greenberg, Georg Norén, Steven A Rasmussen, Hermano Tavares, Eurípedes C Miguel, Antonio C Lopes, Marcelo Q Hoexter
BACKGROUND: Neurosurgeries such as gamma ventral capsulotomy (GVC) are an option for otherwise intractable obsessive-compulsive disorder (OCD) patients. In general, clinical and neuropsychological status both improve after GVC. However, its consequences on personality traits are not well-studied. The objective of this study was to investigate personality changes after one year of GVC in intractable OCD patients. METHODS: The personality assessment was conducted using the Revised NEO Personality Inventory (NEO PI-R) and Cloninger's Temperament and Character Inventory (TCI) in 14 intractable OCD patients before and one year after GVC...
November 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29100973/evaluating-psychiatric-symptoms-in-parkinson-s-disease-by-a-clinimetric-analysis-of-the-hopkins-symptom-checklist-scl-90-r
#15
Danilo Carrozzino, Bo Mohr Morberg, Chiara Siri, Gianni Pezzoli, Per Bech
Although psychiatric comorbidity in Parkinson's Disease (PD) has often been studied, the individual psychiatric symptoms have rarely been evaluated from a clinimetric point of view in an attempt to measure how much the symptoms have been bothering or distressing the PD patients. The current study is therefore aimed at evaluating from a clinimetric viewpoint the severity of psychiatric symptoms affecting PD patients by using the Hopkins Symptom Checklist (SCL-90-R) to show its measurement-driven construct validity (scalability)...
November 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29100974/the-interaction-of-nos1ap-disc1-daoa-and-gsk3b-confers-susceptibility-of-early-onset-schizophrenia-in-chinese-han-population
#16
Guoqin Hu, Chengqing Yang, Lei Zhao, Yong Fan, Qinyu Lv, Jing Zhao, Minghuan Zhu, Xiangqing Guo, Chenxi Bao, Ahong Xu, Yong Jie, Yaqing Jiang, Chen Zhang, Shunying Yu, Zuowei Wang, Zezhi Li, Zhenghui Yi
Although many major breakthrough had identificated potential susceptibility genes for schizophrenia, the aetiology of schizophrenia is still unknown. In the present study, we focused on the N-methyl-Daspartate receptors related genes nitric oxide synthase 1 adaptor gene (NOS1AP), disrupted in schizophrenia 1 gene (DISC1), d-amino acid oxidase activator gene (DAOA), and glycogen synthase kinase 3-beta gene (GSK3B). A family-based genetic association study (459 Han Chinese subjects in 153 nuclear families) using 3 single nucleotide polymorphisms in NOS1AP, 2 in DISC1, 1 in DAOA and 1 in GSK3B was conducted...
October 31, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29097257/a-randomized-13-week-study-assessing-the-efficacy-and-metabolic-effects-of-paliperidone-palmitate-injection-and-olanzapine-in-first-episode-schizophrenia-patients
#17
Manli Huang, Liang Yu, Fen Pan, Shaojia Lu, Shaohua Hu, Jianbo Hu, Jinkai Chen, Pingbo Jin, Hongli Qi, Yi Xu
BACKGROUND: This study was conducted to evaluate the efficacy and metabolic effects of paliperidone palmitate (PP) injections against oral olanzapine in first-episode schizophrenia (FES) patients. METHODS: Eligible patients were randomized to receive PP or olanzapine. Efficacy assessments and weight-related parameters were assessed at baseline, weeks 1, 5, 9, and endpoint or at early withdrawal. Lipid, glucose, insulin and prolactin were evaluated at baseline and endpoint or at early withdrawal...
October 31, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29097256/the-pathophysiological-mechanisms-of-motivational-deficits-in-parkinson-s-disease
#18
REVIEW
A Chagraoui, L Boukhzar, F Thibaut, Y Anouar, D Maltête
Parkinson's disease (PD) is a progressive degenerative disorder that leads to disabling motor symptoms and a wide variety of neuropsychiatric symptoms. Apathy is the most common psychiatric disorder in the early stages of untreated PD and can be defined as a hypodopaminergic syndrome, which also includes anxiety and depression. Apathy is also considered the core feature of the parkinsonian triad (apathy, anxiety and depression) of behavioural non-motor signs, including a motivational deficit. Moreover, apathy is recognised as a distinct chronic neuropsychiatric behavioural disorder based on specific diagnostic criteria...
October 31, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29097255/association-of-pik3cg-gene-polymorphisms-with-attention-deficit-hyperactivity-disorder-a-case-control-study
#19
Xue Gu, Fang-Fen Yuan, Xin Huang, Yuwei Hou, Min Wang, Jun Lin, Jing Wu
Attention-deficit/hyperactivity disorder (ADHD) is a complicated neurodevelopmental disorder with high heritability. This study explores the association of PIK3CG gene single nucleotide polymorphisms (rs1129293, rs12536620, rs12667819, rs17847825, rs2230460) with ADHD in children and the relation of interaction between SNPs and environmental factors, including blood lead levels (BLLs) and feeding style. A case-control study was conducted with children aged 6-18years old, consisting of 389 children newly diagnosed with ADHD via the DSM-IV at the Wuhan Women and Children Medical Care Center, and 393 control participants were healthy children for physical examination during the same period...
October 31, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29111406/panic-like-escape-response-elicited-in-mice-by-exposure-to-co2-but-not-hypoxia
#20
Ailton Spiacci, Heloisa H Vilela-Costa, Ana Beatriz Sant'Ana, Gabriel Gripp Fernandes, Alana Tercino Frias, Glauber S Ferreira da Silva, José Antunes-Rodrigues, Hélio Zangrossi
Exposure to elevated concentrations of CO2 or hypoxia has been widely used in psychiatric research as a panic provoking stimulus. However, the use of these respiratory challenges to model panic-like responses in experimental animals has been less straightforward. Little data is available, from behavioral and endocrine perspectives, to support the conclusion that a marked aversive situation, such as that experienced during panic attacks, was evoked in these animals. We here compared the behavioral responses of male CB57BL/6 mice during exposure to 20% CO2 or 7% O2 and its consequence on plasma levels of corticosterone...
October 28, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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