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Journals Progress in Neuro-psychopharma...

Progress in Neuro-psychopharmacology & Biological Psychiatry

https://read.qxmd.com/read/38490433/the-bidirectional-relationship-of-depression-and-disturbances-in-b-cell-homeostasis-double-trouble
#1
REVIEW
Shusheng Wu, Yuye Yin, Longfei Du
Major depressive disorder (MDD) is a recurrent, persistent, and debilitating neuropsychiatric syndrome with an increasing morbidity and mortality, representing the leading cause of disability worldwide. The dysregulation of immune systems (including innate and adaptive immune systems) has been identified as one of the key contributing factors in the progression of MDD. As the main force of the humoral immunity, B cells have an essential role in the defense against infections, antitumor immunity and autoimmune diseases...
March 13, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38484929/antidepressant-effects-of-esketamine-via-the-bdnf-akt-mtor-pathway-in-mice-with-postpartum-depression-and-their-offspring
#2
JOURNAL ARTICLE
Han Qin, Miao Yu, Nianjiao Han, Meilin Zhu, Xia Li, Jing Zhou
Postpartum depression (PPD) is a serious mental health problem that can negatively affect future generations. BDNF/AKT/mTOR signaling in the frontal lobe and hippocampus in mice is associated with depression, but its role in mice with PPD and their offspring is unknown. This study was aimed at investigating the effects of esketamine (ESK), a drug approved for treatment of refractory depression, on the BDNF/AKT/mTOR pathway in mice with PPD and their offspring. A model of chronic unpredictable mild stress with pregnancy was used...
March 13, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38484928/heterogeneity-in-functional-connectivity-dimensional-predictors-of-individual-variability-during-rest-and-task-fmri-in-psychosis
#3
JOURNAL ARTICLE
Maria T Secara, Lindsay D Oliver, Julia Gallucci, Erin W Dickie, George Foussias, James Gold, Anil K Malhotra, Robert W Buchanan, Aristotle N Voineskos, Colin Hawco
BACKGROUND: Individuals with schizophrenia spectrum disorders (SSD) often demonstrate cognitive impairments, associated with poor functional outcomes. While neurobiological heterogeneity has posed challenges when examining social cognition in SSD, it provides a unique opportunity to explore brain-behavior relationships. The aim of this study was to investigate the relationship between individual variability in functional connectivity during resting state and the performance of a social task and social and non-social cognition in a large sample of controls and individuals diagnosed with SSD...
March 12, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38467326/d-pinitol-mitigates-post-traumatic-stress-disorder-like-behaviors-induced-by-single-prolonged-stress-in-mice-through-mineralocorticoid-receptor-antagonism
#4
JOURNAL ARTICLE
Chang Hyeon Kong, Jin Woo Lee, Mijin Jeon, Woo Chang Kang, Min Seo Kim, Keontae Park, Ho Jung Bae, Se Jin Park, Seo Yun Jung, Su-Nam Kim, Benjamin Kleinfelter, Ji-Woon Kim, Jong Hoon Ryu
Post-traumatic stress disorder (PTSD) is a mental illness that can occur in individuals who have experienced trauma. Current treatments for PTSD, typically serotonin reuptake inhibitors, have limited effectiveness for patients and often cause serious adverse effects. Therefore, a novel class of treatment with better pharmacological profile is necessary. D-Pinitol has been reported to be effective for depression and anxiety disorders, but there are no reports associated with PTSD. In the present study, we investigated the effects of D-pinitol in a mouse model of PTSD induced by a single prolonged stress (SPS) protocol...
March 9, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38458345/editorial-progress-in-understanding-cognitive-dysfunction-in-severe-psychiatric-disorders
#5
JOURNAL ARTICLE
Synthia Guimond, Tamsyn E Van Rheenen
No abstract text is available yet for this article.
March 6, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38438071/multi-platform-omics-sequencing-dissects-the-atlas-of-plasma-derived-exosomes-in-rats-with-or-without-depression-like-behavior-after-traumatic-spinal-cord-injury
#6
JOURNAL ARTICLE
Zhi-Hua Wang, Zhi-Ping Xie, Zhi-Xiong Zhang, Wu Zhou, Bo-Yu Guo, Mei-Hua Li
BACKGROUND: Exosomes can penetrate the blood-brain barrier for material exchange between the peripheral and central nervous systems. Differences in exosome contents could explain the susceptibility of different individuals to depression-like behavior after traumatic spinal cord injury (TSCI). METHODS: Hierarchical clustering was used to integrate multiple depression-related behavioral outcomes in sham and TSCI rats and ultimately identify non-depressed and depressed rats...
March 2, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38430954/novel-genetic-loci-of-inhibitory-control-in-adhd-and-healthy-children-and-genetic-correlations-with-adhd
#7
JOURNAL ARTICLE
Tao Pang, Ning Ding, Yilu Zhao, Jingjing Zhao, Li Yang, Suhua Chang
Cumulative evidence has showed the deficits of inhibitory control in patients with attention deficit hyperactivity disorder (ADHD), which is considered as an endophenotype of ADHD. Genetic study of inhibitory control could advance gene discovery and further facilitate the understanding of ADHD genetic basis, but the studies were limited in both the general population and ADHD patients. To reveal genetic risk variants of inhibitory control and its potential genetic relationship with ADHD, we conducted genome-wide association studies (GWAS) on inhibitory control using three datasets, which included 783 and 957 ADHD patients and 1350 healthy children...
February 29, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38430953/genome-wide-association-studies-gwas-and-post-gwas-analyses-of-impulsivity-a-systematic-review
#8
REVIEW
Jiaqi Wang, Ruolei Gu, Xiangzhen Kong, Shenghua Luan, Yu L L Luo
Impulsivity is related to a host of mental and behavioral problems. It is a complex construct with many different manifestations, most of which are heritable. The genetic compositions of these impulsivity manifestations, however, remain unclear. A number of genome-wide association studies (GWAS) and post-GWAS analyses have tried to address this issue. We conducted a systematic review of all GWAS and post-GWAS analyses of impulsivity published up to December 2023. Available data suggest that single nucleotide polymorphisms (SNPs) in more than a dozen of genes (e...
February 29, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38423354/efficacy-and-acceptability-of-s-adenosyl-l-methionine-same-for-depressed-patients-a-systematic-review-and-meta-analysis
#9
REVIEW
Nahathai Limveeraprajak, Sirapop Nakhawatchana, Apidsada Visukamol, Christsanutth Siripakkaphant, Sirijit Suttajit, Manit Srisurapanont
This systematic review and meta-analysis aimed to assess the efficacy and acceptability of S-adenosyl-L-methionine (SAMe) in treating depression. We conducted a comprehensive search of PubMed, Embase, Cochrane Library, and ClinialTrials.gov from inception to July 3, 2023, identifying randomized controlled trials comparing SAMe with placebo or antidepressants (ADs). We synthesized data on reduced depressive symptoms (efficacy) and overall dropout rates (acceptability) using a random-effects model for pairwise frequentist meta-analysis...
February 27, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38417478/evaluation-of-cannabimimetic-effects-of-selected-minor-cannabinoids-and-terpenoids-in-mice
#10
JOURNAL ARTICLE
Jenny L Wiley, Julie A Marusich, Bruce E Blough, Ojas Namjoshi, Marcus Brackeen, Luli R Akinfiresoye, Teneille D Walker, Cassandra Prioleau, Daniel G Barrus, Thomas F Gamage
BACKGROUND: The cannabis plant contains several cannabinoids, and many terpenoids that give cannabis its distinctive flavoring and aroma. Δ9 -Tetrahydrocannabinol (Δ9 -THC) is the plant's primary psychoactive constituent. Given the abuse liability of Δ9 -THC, assessment of the psychoactive effects of minor cannabinoids and other plant constituents is important, especially for compounds that may be used medicinally. This study sought to evaluate select minor cannabinoids and terpenes for Δ9 -THC-like psychoactivity in mouse Δ9 -THC drug discrimination and determine their binding affinities at CB1 and CB2 receptors...
February 27, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38412941/exploring-the-clinical-potentials-of-zuranolone-in-managing-postpartum-depression-a-new-therapeutic-horizon
#11
JOURNAL ARTICLE
Abdulqadir J Nashwan, Syeda Tayyaba Rehan, Laiba Imran, Samina Ghulam Abbas, Sara Fahim Khan
Postpartum depression (PPD) poses a major threat to maternal mental health and wellbeing while also adversely affecting the mother's relationship with her baby, leading to significant repercussions that may hinder the growth and cognitive development of the child. For decades, antidepressants have been the mainstay of treating PPD; however, recent evidence suggests that antidepressants are not as effective as they are believed to be and there is a dire need to explore new treatment options. In 2023, a breakthrough in treating PPD emerged with the recent FDA approval of zuranolone, a gamma-aminobutyric acid (GABAA ) receptor selective positive allosteric modulator...
February 25, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38387807/the-neural-substrates-responsible-for-punishment-sensitivity-association-with-procrastination-left-putamen-connectivity-with-left-middle-temporal-gyrus
#12
JOURNAL ARTICLE
Zhenzhen Huo, Rong Zhang, Zhiyi Chen, Junye Xu, Ting Xu, Tingyong Feng
Procrastination has adverse consequences across cultural contexts. Behavioral research found a positive correlation between punishment sensitivity and procrastination. However, little is known about the neural substrates underlying the association between them. We employed voxel-based morphometry (VBM) and resting-state functional connectivity (RSFC) methods to address this issue with two independent samples. In Sample 1, behavioral results found that punishment sensitivity was positively related to procrastination...
February 20, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38373628/electroconvulsive-therapy-disrupts-functional-connectivity-between-hippocampus-and-posterior-default-mode-network
#13
JOURNAL ARTICLE
Krzysztof Gbyl, Vytautas Labanaukas, Christoffer Cramer Lundsgaard, André Mathiassen, Adam Ryszczuk, Hartwig Roman Siebner, Egill Rostrup, Kristoffer Madsen, Poul Videbech
BACKGROUND: The mechanisms underlying memory deficits after electroconvulsive therapy (ECT) remain unclear but altered functional interactions between hippocampus and neocortex may play a role. OBJECTIVES: To test whether ECT reduces functional connectivity between hippocampus and posterior regions of the default mode network (DMN) and to examine whether altered hippocampal-neocortical functional connectivity correlates with memory impairment. A secondary aim was to explore if these connectivity changes are present 6 months after ECT...
February 17, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38369099/sex-specific-modulation-of-safety-learning-in-shank2-deficient-mice
#14
JOURNAL ARTICLE
Judith C Kreutzmann, Evelyn Kahl, Markus Fendt
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by impaired perceptual processing and social communication, intellectual disabilities, and repetitive behaviors. Interestingly, while not a core symptom, anxiety disorders frequently co-occur in individuals with ASD and deficits in safety learning have been described in patients with anxiety-related disorders. Because genetic factors, such as SHANK deficiency (loss-of-function mutations), have been linked to ASD, the aim of the present study was to investigate whether Shank2 deficiency interferes with associative fear and safety signal learning...
February 17, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38369098/aberrant-heartbeat-evoked-potential-in-schizophrenia
#15
JOURNAL ARTICLE
Akihiro Koreki, Kamiyu Ogyu, Takahiro Miyazaki, Kazumasa Takenouchi, Karin Matsushita, Shiori Honda, Teruki Koizumi, Mitsumoto Onaya, Hiroyuki Uchida, Masaru Mimura, Shinichiro Nakajima, Yoshihiro Noda
Self-disturbance is considered a core feature underlying the psychopathology of schizophrenia. Interoception has an important role in the development of a sense of self, leading to increased interest in the potential contribution of abnormal interoception to self-disturbances in schizophrenia. Several neuropsychological studies have demonstrated aberrant interoception in schizophrenia. However, cortical interoceptive processing has not yet been thoroughly investigated. Thus, we sought to examine resting-state heartbeat-evoked potential (HEP) in this population...
February 16, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38367896/polygenic-risk-scores-for-mood-and-related-disorders-and-environmental-factors-interaction-effects-on-wellbeing-in-the-uk-biobank
#16
JOURNAL ARTICLE
Chiara Fabbri, Cathryn M Lewis, Alessandro Serretti
Mood disorders have a genetic and environmental component and interactions (GxE) on the risk of psychiatric diseases have been investigated. The same GxE interactions may affect wellbeing measures, which go beyond categorical diagnoses and reflect the health-disease continuum. We evaluated GxE effects in the UK Biobank, considering as outcomes subjective wellbeing (feeling good and functioning well) and objective measures (education and income). We estimated the polygenic risk scores (PRSs) of major depressive disorder, bipolar disorder, schizophrenia, and attention deficit hyperactivity disorder...
February 15, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38365104/dopaminergic-dominance-in-the-ventral-medial-hypothalamus-a-pivotal-regulator-for-methamphetamine-induced-pathological-aggression
#17
JOURNAL ARTICLE
Ludi Zhang, Yufei Sun, Jian Wang, Minglong Zhang, Qingwu Wang, Bing Xie, Feng Yu, Di Wen, Chunling Ma
Methamphetamine (METH) abuse is associated with a spectrum of behavioral consequences, among which heightened aggression presents a significant challenge. However, the causal role of METH's impact in aggression and its target circuit mechanisms remains largely unknown. We established an acute METH exposure-aggression mouse model to investigate the role of ventral tegmental area (VTA) dopaminergic neurons and ventral medial hypothalamus VMH glutamatergic neuron. Our findings revealed that METH-induced VTA dopamine excitability activates the ventromedial hypothalamus (VMH) glutamatergic neurons, contributing to pathological aggression...
February 14, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38365103/increased-grey-matter-volumes-in-the-temporal-lobe-and-its-relationship-with-cognitive-functioning-in-euthymic-patients-with-bipolar-disorder
#18
JOURNAL ARTICLE
D Porta-Casteràs, M Vicent-Gil, M Serra-Blasco, G Navarra-Ventura, B Solé, L Montejo, C Torrent, A Martinez-Aran, V De la Peña-Arteaga, D Palao, E Vieta, N Cardoner, M Cano
BACKGROUND: Bipolar disorder (BD) is characterized by episodic mood dysregulation, although a significant portion of patients suffer persistent cognitive impairment during euthymia. Previous magnetic resonance imaging (MRI) research suggests BD patients may have accelerated brain aging, observed as lower grey matter volumes. How these neurostructural alterations are related to the cognitive profile of BD is unclear. METHODS: We aim to explore this relationship in euthymic BD patients with multimodal structural neuroimaging...
February 14, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38365102/atypical-dynamic-network-reconfiguration-and-genetic-mechanisms-in-patients-with-major-depressive-disorder
#19
JOURNAL ARTICLE
Hairong Xiao, Dier Tang, Chuchu Zheng, Zeyu Yang, Wei Zhao, Shuixia Guo
BACKGROUND: Brain dynamics underlie complex forms of flexible cognition or the ability to shift between different mental modes. However, the precise dynamic reconfiguration based on multi-layer network analysis and the genetic mechanisms of major depressive disorder (MDD) remains unclear. METHODS: Resting-state functional magnetic resonance imaging (fMRI) data were acquired from the REST-meta-MDD consortium, including 555 patients with MDD and 536 healthy controls (HC)...
February 14, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38354899/decreased-short-latency-afferent-inhibition-in-individuals-with-mild-cognitive-impairment-a-tms-eeg-study
#20
JOURNAL ARTICLE
Yu Mimura, Yui Tobari, Shinichiro Nakajima, Mayuko Takano, Masataka Wada, Shiori Honda, Shogyoku Bun, Hajime Tabuchi, Daisuke Ito, Mie Matsui, Hiroyuki Uchida, Masaru Mimura, Yoshihiro Noda
TMS combined with EEG (TMS-EEG) is a tool to characterize the neurophysiological dynamics of the cortex. Among the TMS paradigms, short-latency afferent inhibition (SAI) allows the investigation of inhibitory effects mediated by the cholinergic system. The aim of this study was to compare cholinergic function in the DLPFC between individuals with mild cognitive impairment (MCI) and healthy controls (HC) using TMS-EEG with the SAI paradigm. In this study, 30 MCI and 30 HC subjects were included. The SAI paradigm consisted of 80 single pulse TMS and 80 SAI stimulations applied to the left DLPFC...
February 12, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
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