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Progress in Neuro-psychopharmacology & Biological Psychiatry

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https://www.readbyqxmd.com/read/28918267/compulsivity-in-opioid-dependence
#1
Serenella Tolomeo, Keith Matthews, J Douglas Steele, Alex Baldacchino
OBJECTIVE: This study aimed to investigate the relationship between compulsivity versus impulsivity and structural MRI abnormalities in opioid dependence. METHOD: We recruited 146 participants: i) patients with a history of opioid dependence due to chronic heroin use (n=24), ii) heroin users stabilised on methadone maintenance treatment (n=48), iii) abstinent participants with a history of opioid dependence due to heroin use (n=24) and iv) healthy controls (n=50)...
September 13, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28912043/abnormal-segments-of-right-uncinate-fasciculus-and-left-anterior-thalamic-radiation-in-major-and-bipolar-depression
#2
Feng Deng, Ying Wang, Huiyuan Huang, Meiqi Niu, Shuming Zhong, Ling Zhao, Zhangzhang Qi, Xiaoyan Wu, Yao Sun, Chen Niu, Yuan He, Li Huang, Ruiwang Huang
Differential brain structural abnormalities between bipolar disorder (BD) and major depressive disorder (MDD) may reflect different pathological mechanisms underlying these two brain disorders. However, few studies have directly compared the brain structural properties, especially in white matter (WM) tracts, between BD and MDD. Using automated fiber-tract quantification (AFQ), we utilized diffusion tensor images (DTI) from 67 unmedicated depressed patients, including 31 BD and 36 MDD, and 45 healthy controls (HC) to create fractional anisotropy (FA) tract profiles along 20 major WM tracts...
September 11, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28899646/early-life-adversity-potentiates-expression-of-addiction-related-traits
#3
Tristan J Hynes, Catherine S Thomas, Alicia S Zumbusch, Anna Samson, Ioana Petriman, Una Mrdja, Angelique Orr, Emilie Cutts, Bruce G Ruzindana, Alimohamed Hazari, Margaret Zjadewicz, Vedran Lovic
Many individuals sporadically and circumstantially sample addictive drugs, yet few become addicted. The individual vulnerabilities underlying the development of addiction are not well understood. Correlational findings show that early life adversity is associated with a greater propensity to develop drug addiction. However, the mechanisms by which early life adversity increases addiction vulnerability are unknown. Separate lines of research have found that several traits are associated with addiction. Here, we examined the effects of early life adversity on addiction-related traits in adulthood...
September 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28887182/behavioral-and-neural-mechanisms-underlying-habitual-and-compulsive-drug-seeking
#4
REVIEW
Rachel J Smith, Lillian S Laiks
Addiction is characterized by compulsive drug use despite negative consequences. Here we review studies that indicate that compulsive drug use, and in particular punishment resistance in animal models of addiction, is related to impaired cortical control over habitual behavior. In humans and animals, instrumental behavior is supported by goal-directed and habitual systems that rely on distinct corticostriatal networks. Chronic exposure to addictive drugs or stress has been shown to bias instrumental response strategies toward habit learning, and impair prefrontal cortical (PFC) control over responding...
September 5, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28887181/treatment-resistant-schizophrenia-and-neurological-soft-signs-may-converge-on-the-same-pathology-evidence-from-explanatory-analysis-on-clinical-psychopathological-and-cognitive-variables
#5
Andrea de Bartolomeis, Emiliano Prinzivalli, Gemma Callovini, Luigi D'Ambrosio, Benedetta Altavilla, Camilla Avagliano, Felice Iasevoli
Here, we investigated neurological soft signs (NSSs) in treatment resistant schizophrenia (TRS) vs treatment responder schizophrenia (SZ) patients. TRS is a severe condition, affecting approximately one-third of schizophrenia patients and representing a relevant clinical challenge. NSSs are neurological abnormalities reportedly described in schizophrenia patients and linked to dysregulated network connections. We explored the possibility that NSSs may be: i) more severe in TRS patients; ii) differentially associated to clinical/cognitive variables in TRS vs SZ; iii) predictive of having TRS...
September 5, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28887180/gray-matter-volume-showed-dynamic-alterations-in-methamphetamine-users-at-6-and-12months-abstinence-a-longitudinal-voxel-based-morphometry-study
#6
Ruan Xiaolu, Zhong Na, Yang Zhi, Fan Xiaoduo, Zhuang Wenxu, Du Jiang, Jiang Haifeng, Zhao Min
BACKGROUND: Previous studies have demonstrated brain gray matter reduction in methamphetamine (MA) users; however, little is known about longitudinal brain structural alternations during abstinence. METHOD: Brain volumes were compared among 30 MA-dependent patients (average 6.3years of drug use) at 6months' abstinence and 27 drug-naïve controls by voxel-based morphometry. A longitudinal analysis of MA subjects was performed from 6 to 12months' abstinence, and multiple regression analyses were performed between drug use patterns and gray matter volumes (GMV) at 6months' abstinence...
September 5, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28882428/the-effect-of-mianserin-on-the-severity-of-psychosis-and-dyskinesia-in-the-parkinsonian-marmoset
#7
Adjia Hamadjida, Stephen G Nuara, Jim C Gourdon, Philippe Huot
No abstract text is available yet for this article.
September 5, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28870635/cannabidiol-inhibits-priming-induced-reinstatement-of-methamphetamine-in-rem-sleep-deprived-rats
#8
Saeideh Karimi-Haghighi, Abbas Haghparast
Methamphetamine (METH) is a widely abused and a severely addictive psychostimulant. Relapse is the main cause of concern when treating addiction. It could manifest after a long period of abstinence. Previous studies showed that there is a strong connection between sleep impairment and relapse. Also, it has been reported that cannabidiol might be a potential treatment for drug craving and relapse. In this study, we used conditioned place preference (CPP) to investigate whether Cannabidiol (CBD), a phytocannabinoid, can prevent METH-induced reinstatement in Rapid Eye Movement Sleep Deprived (RSD) rats...
September 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28870634/dendritic-spine-actin-cytoskeleton-in-autism-spectrum-disorder
#9
REVIEW
Merja Joensuu, Vanessa Lanoue, Pirta Hotulainen
Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the postsynaptic part of most excitatory synapses. Changes in the shape and size of dendritic spines correlate with the functional changes in excitatory synapses and are heavily dependent on the remodeling of the underlying actin cytoskeleton. Recent evidence implicates synapses at dendritic spines as important substrates of pathogenesis in neuropsychiatric disorders, including autism spectrum disorder (ASD). Although synaptic perturbations are not the only alterations relevant for these diseases, understanding the molecular underpinnings of the spine and synapse pathology may provide insight into their etiologies and could reveal new drug targets...
September 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28867391/are-there-differences-in-lipid-peroxidation-and-immune-biomarkers-between-major-depression-and-bipolar-disorder-effects-of-melancholia-atypical-depression-severity-of-illness-episode-number-suicidal-ideation-and-prior-suicide-attempts
#10
Magdalena Sowa-Kućma, Krzysztof Styczeń, Marcin Siwek, Paulina Misztak, Rafał J Nowak, Dominika Dudek, Janusz K Rybakowski, Gabriel Nowak, Michael Maes
BACKGROUND: There is evidence that major depression (MDD) and bipolar disorder (BD) are accompanied by activated immune & oxidative (I&O) pathways. METHODS: To compare I&O biomarkers between MDD and BD we assessed serum levels of thiobarbituric acid reactive substances (TBARS; a lipid peroxidation marker), soluble interleukin-2 receptor (sIL-2R), sIL-6R, IL-α, sIL-1R antagonist (sIL-1RA), tumor necrosis factor receptor 60kDa/80kDa (sTNFR60/R80) in 114 MDD and 133 BD patients, and 50 healthy controls...
September 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28867392/effects-of-alprazolam-treatment-on-anxiety-like-behavior-induced-by-color-stimulation-in-adult-zebrafish
#11
Mateusz Pieróg, Leszek Guz, Urszula Doboszewska, Ewa Poleszak, Piotr Wlaź
It has been reported that the use of certain stimuli can lead to anxiety-like behavior in zebrafish. Moreover, visual stimulation of zebrafish is becoming a popular tool. Here we evaluated the effects of six colors combinations and alprazolam, a benzodiazepine which is widely used in the treatment of anxiety disorders, on the behavior of adult zebrafish in a two-chambered apparatus, which chambers were illuminated by red/yellow, green/blue, red/green, green/yellow, red/blue and blue/yellow light. The following parameters were measured: time spent in the zone, number of entries to the zone, time of freezing, distance traveled and average speed in the zone...
August 31, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28847526/modeling-consequences-of-prolonged-strong-unpredictable-stress-in-zebrafish-complex-effects-on-behavior-and-physiology
#12
Cai Song, Bai-Ping Liu, Yong-Ping Zhang, Zhilan Peng, JiaJia Wang, Adam D Collier, David J Echevarria, Katerina V Savelieva, Robert F Lawrence, Christopher S Rex, Darya A Meshalkina, Allan V Kalueff
Chronic stress is the major pathogenetic factor of human anxiety and depression. Zebrafish (Danio rerio) have become a novel popular model species for neuroscience and CNS drug discovery. The utility of zebrafish for mimicking human affective disorders is also rapidly growing. Here, we develop a new zebrafish model of clinically relevant, prolonged unpredictable chronic stress (PUCS). The 5-week PUCS induced overt anxiety-like and motor retardation-like behaviors in adult zebrafish, also elevating whole-body cortisol and proinflammatory cytokines interleukins IL-1β and IL-6...
August 25, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28847525/chronic-pain-and-suicide-risk-a-comprehensive-review
#13
REVIEW
Mélanie Racine
Death by suicide is one of the leading causes of mortality worldwide. Because individuals with chronic pain are at least twice as likely to report suicidal behaviors or to complete suicide, it is of utmost importance to target which risk factors contribute the most to increasing suicidality. This comprehensive review aims to provide an update on research advancements relating to the identification of potential risk factors for suicidality in individuals with chronic pain. Supporting the results of prior reviews, we found robust evidence that chronic pain itself, regardless of type, was an important independent risk factor for suicidality...
August 26, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28844717/intranasal-oxytocin-reduces-heart-rate-variability-during-a-mental-arithmetic-task-a-randomised-double-blind-placebo-controlled-cross-over-study
#14
Lincoln M Tracy, Stephen J Gibson, Izelle Labuschagne, Nellie Georgiou-Karistianis, Melita J Giummarra
Heart rate variability (HRV) refers to variation in the interval between successive heart beats. Low HRV is an indicator of potential autonomic nervous system dysfunction. People with chronic pain often display autonomic dysregulation, especially in the parasympathetic nervous system. The hormone oxytocin has been shown to increase HRV in non-clinical samples, but its potential impact on HRV in persons with chronic pain is unknown. This study investigated the impact of intranasal oxytocin on HRV in persons with chronic neck and shoulder pain...
August 24, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28842257/antidepressant-and-pro-neurogenic-effects-of-agmatine-in-a-mouse-model-of-stress-induced-by-chronic-exposure-to-corticosterone
#15
Gislaine Olescowicz, Vivian B Neis, Daiane B Fraga, Priscila B Rosa, Dayane P Azevedo, Fernando Falkenburger Melleu, Patricia S Brocardo, Joana Gil-Mohapel, Ana Lúcia S Rodrigues
Agmatine is an endogenous neuromodulator that has been shown to have beneficial effects in the central nervous system, including antidepressant-like effects in animals. In this study, we investigated the ability of agmatine (0.1mg/kg, p.o.) and the conventional antidepressant fluoxetine (10mg/kg, p.o.) to reverse the behavioral effects and morphological alterations in the hippocampus of mice exposed to chronic corticosterone (20mg/kg, p.o.) treatment for a period of 21days as a model of stress and depressive-like behaviors...
August 24, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28830794/regulation-of-gene-transcription-in-bipolar-disorders-role-of-dna-methylation-in-the-relationship-between-prodynorphin-and-brain-derived-neurotrophic-factor
#16
Claudio D'Addario, Maria Carlotta Palazzo, Beatrice Benatti, Benedetta Grancini, Mariangela Pucci, Andrea Di Francesco, Giulia Camuri, Daniela Galimberti, Chiara Fenoglio, Elio Scarpini, A Carlo Altamura, Mauro Maccarrone, Bernardo Dell'Osso
Bipolar Disorder (BD) is a prevalent and disabling condition, determined by gene-environment interactions, possibly mediated by epigenetic mechanisms. The present study aimed at investigating the transcriptional regulation of BD selected target genes by DNA methylation in peripheral blood mononuclear cells of patients with a DSM-5 diagnosis of type I (BD-I) and type II (BD-II) Bipolar Disorders (n=99), as well as of healthy controls (CT, n=42). The analysis of gene expression revealed prodynorphin (PDYN) mRNA levels significantly reduced in subjects with BD-II but not in those with BD-I, when compared to CT...
August 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28826637/sex-differences-in-the-effects-of-pre-and-postnatal-caffeine-exposure-on-behavior-and-synaptic-proteins-in-pubescent-rats
#17
Cássia Sallaberry, Ana Paula Ardais, Andréia Rocha, Maurício Felisberto Borges, Gabriela T Fioreze, Sabrina Mioranzza, Fernanda Nunes, Natália Pagnussat, Paulo Henrique S Botton, Lisiane O Porciúncula
Few studies have addressed the effects of caffeine in the puberty and/or adolescence in a sex dependent manner. Considering that caffeine intake has increased in this population, we investigated the behavioral and synaptic proteins changes in pubescent male and female rats after maternal consumption of caffeine. Adult female Wistar rats started to receive water or caffeine (0.1 and 0.3g/L in drinking water; low and moderate dose, respectively) during the active cycle at weekdays, two weeks before mating. The treatment lasted up to weaning and the offspring received caffeine until the onset of puberty (30-34days old)...
August 18, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28823848/decreased-cerebral-blood-flow-in-the-primary-motor-cortex-in-major-depressive-disorder-with-psychomotor-retardation
#18
Yingying Yin, Meijian Wang, Ze Wang, Chunming Xie, Haisan Zhang, Hongxing Zhang, Zhijun Zhang, Yonggui Yuan
Psychomotor retardation (PMR) is one of the core symptoms of major depressive disorder (MDD) and has a specific pathophysiology, but studies of PMR remains sparse. The purpose of this study was to explore the cerebral blood flow (CBF) of PMR in MDD. One-hundred-seven antidepressant-free MDD patients and 48 normal controls (NCs) were recruited for this study. All subjects underwent arterial spin labeling-magnetic resonance imaging (ASL-MRI) for the CBF calculation. MDD patients were divided into the PMR group (N=35) and NPMR (non-PMR) group (N=72) according to the Salpetriere Retardation Rating Scale (SRRS) score...
August 18, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28823850/abnormal-long-and-short-range-functional-connectivity-in-adolescent-onset-schizophrenia-patients-a-resting-state-fmri-study
#19
Shuai Wang, Yajing Zhan, Yan Zhang, Luxian Lyu, Hailong Lyu, Guodong Wang, Renrong Wu, Jingping Zhao, Wenbin Guo
BACKGROUND: Human brain is a topologically complex network embedded in anatomical space, and anatomical distance may affect functional connectivity (FC) in schizophrenia. However, little is known if and how this effect occurs in adolescent-onset schizophrenia (AOS). METHODS: We explored long- and short-range FC through resting-state functional magnetic resonance imaging in 48 first-episode, drug-naive AOS patients and 31 healthy controls, and we examined if these abnormalities could be utilized to separate patients from controls using receiver operating characteristic curves and support vector machines (SVM)...
August 17, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28823849/sex-differences-in-cardiovascular-neuroendocrine-and-behavioral-changes-evoked-by-chronic-stressors-in-rats
#20
Jonas O Vieira, Josiane O Duarte, Willian Costa-Ferreira, Gessynger Morais-Silva, Marcelo T Marin, Carlos C Crestani
This study investigated the physiological, somatic and behavioral changes evoked by daily exposure to the same type of stressor (homotypic) or different aversive stressor stimuli (heterotypic) in male and female rats. For this, adult Wistar rats were subjected to a 10days regimen of repeated restraint stress (RRS, homotypic stressor) or chronic variable stress (CVS, heterotypic stressor). Effects evoked by CVS included: (i) adrenal hypertrophy and decreased body weight gain in male animals, (ii) a sympathetically-mediated increase in basal heart rate in males, and (iii) a rise in plasma corticosterone concentration and anxiogenic effects in female animals...
August 17, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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