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Progress in Neuro-psychopharmacology & Biological Psychiatry

Shitao Rao, Xinyu Han, Mai Shi, Cynthia O Siu, Mary Miu Yee Waye, Guangming Liu, Yun Kwok Wing
BACKGROUND: Associations of the serotonin transporter promoter polymorphism (5-HTTLPR) with bipolar disorder (BPD) and treatment response in bipolar patients were not conclusive. This study not only assessed the association between the 5-HTTLPR and BPD with accumulating relevant studies, but also in the first time evaluated the effect of the 5-HTTLPR on both anti-depressive and anti-manic treatment responses in bipolar patients. METHODS: PubMed, Embase, PsycINFO, Cochrane Library and Cochrane Control Trials databases were systematically searched before February 2017...
September 11, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Julia J Rucklidge, Matthew J F Eggleston, Kathryn Darling, Aaron Stevens, Martin Kennedy, Christopher M Frampton
BACKGROUND: Intent-to-treat analyses from a randomized controlled trial showed significant between-group differences favouring micronutrient treatment on the Clinical Global Impression-Improvement, but no group differences on clinician, parent and teacher ratings of overall ADHD symptoms. There was an advantage of micronutrients over placebo in improving overall function, emotional regulation, aggression, and reducing impairment as well as improving inattention based on clinician but not parent observation...
September 11, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Julius Schuster, Ellen S Mitchell
In general, preparations of coffee, teas, and cocoa containing high levels of polyphenols, L-theanine and other bioactive compounds selectively enhance mood and cognition effects of caffeine. This review summarizes the bioactive components of commonly consumed natural caffeine sources (e.g. guayusa, mate and camellia teas, coffee and cocoa) and analyzes the psychopharmacology of constituent phytochemicals: methylxanthines, polyphenols, and L-theanine. Acute and chronic synergistic effects of these compounds on mood and cognition are compared and discussed...
September 10, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
H Palma-Gudiel, V Peralta, M Deuschle, V Navarro, L Fañanás
BACKGROUND: Depression, anxiety and somatoform disorders are all more prevalent in women than in men. However, specific biological mechanisms contributing to such sex differences remain unknown. Serotonergic pathways are involved in mood and behavior regulation and thus have been suggested to be altered in several psychiatric disorders. The serotonin transporter (SERT), encoded by SLC6A4 gene, has received major attention due to its crucial role in serotonergic transmission. METHODS: 148 monozygotic twin subjects were assessed for (i) lifetime categorical diagnosis of anxious-depressive disorders, following SCID-I-based DSM-IV criteria, and (ii) current psychiatric symptomatology, from a dimensional approach, by means of the Brief Symptom Inventory (BSI)...
September 8, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Kai G Kahl, Britta Stapel, Helge Frieling
Major depression is the most common mental disorder and a leading cause of years lived with disability. In addition to the burden attributed to depressive symptoms and reduced daily life functioning, people with major depression are at increased risk of premature mortality, particularly due to cardiovascular diseases. Several studies point to a bi-directional relation between major depression and cardiovascular diseases, thereby indicating that both diseases may share common pathophysiological pathways. These include lifestyle factors (e...
September 6, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Boyd R Rorabaugh, Albert D Bui, Sarah L Seeley, Eric D Eisenmann, Robert M Rose, Brandon L Johnson, Madelaine R Huntley, Megan E Heikkila, Phillip R Zoladz
No abstract text is available yet for this article.
September 5, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Daifeng Dong, Qingsen Ming, Xue Zhong, Weidan Pu, Xiaocui Zhang, Yali Jiang, Yidian Gao, Xiaoqiang Sun, Xiang Wang, Shuqiao Yao
BACKGROUND: It has been proposed that state-independent, or trait, neurobiological alterations across illness phases may contribute to the high recurrence of major depressive disorder (MDD). Although intrinsic brain network abnormalities have been implicated consistently in MDD neuropathology, MDD state-independent and -dependent resting-state network alterations have not been clearly studied. METHODS: Resting-state functional magnetic resonance imaging (fMRI) data were collected from 57 medication-naive first-episode current MDD patients, 35 remitted MDD patients, and 66 healthy controls (HCs)...
September 5, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Nicolas Zink, Rui Zhang, Witold X Chmielewski, Christian Beste, Ann-Kathrin Stock
It is well-known that alcohol impairs behavioral control and motor response inhibition, but it has remained rather unclear whether it also impairs cognitive inhibition. As automatized behavior is less vulnerable towards the detrimental effects of alcohol than cognitive control processes, potential cognitive inhibition deficits might however improve with training. We investigated the effect of an acute, binge-like alcohol intoxication in a balanced within-subjects design, asking n=32 healthy young males to perform a backward inhibition paradigm once sober and once while intoxicated (~1...
September 5, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Francis L Pazini, Mauricio P Cunha, Ana Lúcia S Rodrigues
Depression, a highly prevalent neuropsychiatric disorder worldwide, causes a heavy burden for the society and is associated with suicide risk. The treatment of this disorder remains a challenge, since currently available antidepressants provide a slow and, often, incomplete response and cause several side effects that contribute to diminish the adhesion of patients to treatment. In this context, several nutraceuticals have been investigated regarding their possible beneficial effects for the management of this neuropsychiatric disorder...
September 4, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Thomas Schnell, Karsten Heekeren, Jörg Daumann, Euphrosyne Gouzoulis-Mayfrank
Research concerning the spatial orientation in patients with schizophrenia has demonstrated a state independent deficit in inhibition of return (IOR), which has been discussed as a vulnerability marker for schizophrenia. Other recent investigations on brain structure and cognitive processing have revealed less deficits in schizophrenia patients with comorbid cannabis use (SCH + CUD) compared to abstinent schizophrenia patients (SCH). It was hypothesized that these results may reflect a premorbid lower vulnerability in at least a subgroup of comorbid patients...
September 2, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Miracle Ozzoude, Shinichiro Nakajima, Eric Plitman, Jun Ku Chung, Julia Kim, Yusuke Iwata, Fernando Caravaggio, Hiroyoshi Takeuchi, Hiroyuki Uchida, Ariel Graff-Guerrero, Philip Gerretsen
BACKGROUND: The relationship between dopamine D2 receptor (D2 R) occupancy and impaired illness awareness (IIA) remains unclear. While IIA is associated with illness severity and cognitive dysfunction, antipsychotic medication, the principal treatment for schizophrenia, indirectly improves IIA, but may simultaneously contribute to cognitive dysfunction at supratherapeutic doses. AIM AND METHODS: We investigated the influence of estimated D2 R (Est.D2 R) occupancy by antipsychotics on the relationship between IIA and illness severity, and IIA and cognition...
August 30, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Chang-Chih Huang, Shin-Chang Kuo, Ta-Chuan Yeh, Yi-Wei Yeh, Chun-Yen Chen, Chih-Sung Liang, Chang-Chih Tsou, Chun-Long Lin, Pei-Shen Ho, San-Yuan Huang
Exposure to stress not only increases the vulnerability to heroin dependence (HD) but also provokes relapse. The etiology of HD and the role of life stress remain unclear, but prior studies suggested that both genetic and environmental factors are important. Opioid related genes, including OPRM1, OPRD1, OPRK1, and POMC, are obvious candidates for HD. Therefore, this study was conducted to explore whether the genetic polymorphisms of the candidates could affect vulnerability to HD and response to life stress in patients with HD...
August 30, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Daniel F Hermens, Sean N Hatton, Django White, Rico S C Lee, Adam J Guastella, Elizabeth M Scott, Sharon L Naismith, Ian B Hickie, Jim Lagopoulos
Diffusion tensor imaging (DTI) has been utilized to index white matter (WM) integrity in the major psychiatric disorders. However, the findings within and across such disorders have been mixed. Given this, transdiagnostic sampling with data-driven statistical approaches may lead to new and better insights about the clinical and functional factors associated with WM abnormalities. Thus, we undertook a cross-sectional DTI study of 401 young adult (18-30 years old) outpatients with a major psychiatric (depressive, bipolar, psychotic, or anxiety) disorder and 61 healthy controls...
August 29, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Shani Poleg, Pavel Golubchik, Daniel Offen, Abraham Weizman
Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication, restricted and repetitive patterns of behavior, interests, or activities and often intellectual disabilities. ASD has a number of prevalent co-morbidities, such as sleep disorders, attention deficit/hyperactivity disorder and epilepsy. No effective treatment for the core symptoms of ASD is currently available. There is increasing interest in cannabinoids, especially cannabidiol (CBD), as monotherapy or add-on treatment for the core symptoms and co-morbidities of ASD...
August 29, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Fatma Ayhan, Genevieve Konopka
Autism spectrum disorder (ASD) is a highly prevalent and complex genetic disorder. The complex genetic make-up of ASD has been extensively studied and both common and rare genetic variants in up to 1000 genes have been linked to increased ASD risk. While these studies highlight the genetic complexity and begin to provide a window for delineating pathways at risk in ASD, the pathogenicity and specific contribution of many mutations to the disorder are poorly understood. Defining the convergent pathways disrupted by this large number of ASD-associated genetic variants will help to understand disease pathogenesis and direct future therapeutic efforts for the groups of patients with distinct etiologies...
August 28, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Dominik P Kiser, Sandy Popp, Angelika G Schmitt-Böhrer, Tatyana Strekalova, Daniel L van den Hove, Klaus-Peter Lesch, Olga Rivero
OBJECTIVE: Cadherin-13 (CDH13), a member of the calcium-dependent cell adhesion molecule family, has been linked to neurodevelopmental disorders, including autism spectrum (ASD) and attention-deficit/hyperactivity (ADHD) disorders, but also to depression. In the adult brain, CDH13 expression is restricted e.g. to the presynaptic compartment of inhibitory GABAergic synapses in the hippocampus and Cdh13 knockout mice show an increased inhibitory drive onto hippocampal CA1 pyramidal neurons, leading to a shift in excitatory/inhibitory balance...
August 27, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Lei Ma, Yong Xu, Gang Wang, Rena Li
Clinical studies have shown that women are more susceptible to depression than men. Sex differences in depression have been associated with social, cultural, as well as biological factors. In spite of extensive preclinical studies in animal models for depression that have been used for understanding the mechanisms of the disease as well as for new drug development, a substantive lack of attention on sex-specific phenotypes in depression might mask the effect of sex on the outcome. In this review article, we summarize findings on the influence of sex on behavior in the most commonly used animal models for depression...
August 27, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Monika Szymanska, Julie Monnin, Grégory Tio, Chrystelle Vidal, Frédérique Girard, Lucie Galdon, Carmela Chateau Smith, Antonia Bifulco, Sylvie Nezelof, Lauriane Vulliez-Coady
According to attachment theory, attachment representations influence emotion regulation (ER) across the lifespan. However, research into attachment-related ER in adolescence is still scarce. The aim of this study was to assess attachment-related ER using a multimodal approach, relying on behavioral and neurophysiological parameters. Attachment styles in eighty-one adolescents were assessed with the Attachment Style Interview (ASI). A distress-then-comfort paradigm based on visual stimuli (the Besancon Affective Picture Set-Adolescents) was employed to "activate" then "deactivate" the attachment system...
August 27, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
G Fond, A Tinland, M Boucekine, V Girard, S Loubière, P Auquier, L Boyer
BACKGROUND: Guidelines have been edited for the treatment of schizophrenia (SZ) and bipolar disorders (BD). Background regimen is currently recommended for both illnesses (antipsychotic drug for SZ and mood stabilizer for BD). The recommendations are less clear for major depression in these disorders. Long-term anxiolytic and hypnotic prescriptions may have potential side effects and should be withdrawn as soon as possible. OBJECTIVE: The aim of this study was to investigate the prevalence and associated factors of Potentially Inappropriate Psychotropic drugs (PIP) in a large multicenter sample of Homeless Schizophrenia (SZ) and Bipolar Disorder (BD) (HSB) patients...
August 25, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Josep Moreno-Rius
The cerebellum is a hindbrain structure which involvement in functions not related to motor control and planning is being increasingly recognized in the last decades. Studies on Autism Spectrum Disorders (ASD) have reported cerebellar involvement on these conditions characterized by social deficits and repetitive motor behavior patterns. Although such an involvement hints at a possible cerebellar participation in the social domain, the fact that ASD patients present both social and motor deficits impedes drawing any firm conclusion regarding cerebellar involvement in pathological social behaviours, probably influenced by the classical view of the cerebellum as a purely "motor" brain structure...
August 25, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
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