journal
https://read.qxmd.com/read/38459357/real-world-evaluation-of-persistence-effectiveness-and-usage-patterns-of-tofacitinib-in-treatment-of-psoriatic-arthritis-in-australia
#21
JOURNAL ARTICLE
Geoffrey Littlejohn, Joanna Leadbetter, Belinda E Butcher, Marie Feletar, Catherine O'Sullivan, Tegan Smith, David Witcombe, Ho Yin Ng, Peter Youssef
OBJECTIVES: To describe treatment patterns and persistence of tofacitinib, interleukin 17 inhibitors (IL-17Ai) and tumour necrosis factor inhibitors (TNFi), in patients with psoriatic arthritis (PsA). METHODS: Data from adult patients with PsA and who had received at least one prescription of tofacitinib, IL-17Ai or TNFi between May 2019 and September 2021 were sourced from the Australian OPAL dataset. Persistence, analysed via Kaplan-Meier methods, and propensity score matching between tofacitinib and bDMARD (IL-17Ai and TNFi) groups were conducted...
March 9, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38459356/clinical-characteristics-of-patients-with-connective-tissue-disease-related-interstitial-lung-disease-a-retrospective-analysis
#22
JOURNAL ARTICLE
Seda Colak, Emre Tekgoz, Ezgi Cimen Gunes, Nesrin Ocal, Deniz Dogan, Canturk Tasci, Muhammet Cinar, Sedat Yilmaz
INTRODUCTION: Interstitial lung disease is one of the most critical manifestations of connective tissue diseases that may cause morbidity and mortality. This study aimed to evaluate the clinical and demographic characteristics and treatment of the patients with connective tissue disease-related interstitial lung disease. METHOD: This retrospective observational study included patients from the Gulhane Rheumatology Interstitial Lung Disease cohort between October 2016 and June 2023...
March 9, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38448745/coffee-intake-reduced-gout-risk-by-decreasing-urate-and-urea-while-increasing-shbg-levels-in-plasma-a-mediation-mendelian-randomization-study
#23
JOURNAL ARTICLE
Tingting Qin, Yuxin Chu, Yi Yao, Cai Zhang, Bin Xu, Qibin Song
OBJECTIVE: This study aims to investigate the causal relationships between specific dietary habits and the risk of gout, while identifying the mediators involved in these associations. METHODS: We initially assessed the causal effects of five dietary habits on gout by two-sample Mendelian randomization (MR). Subsequently, we identified mediators from five plasma metabolites by two-step MR, including urate, urea, sex hormone-binding globulin (SHBG), interleukin-18 (IL-18), and C-reactive protein (CRP)...
March 6, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38446355/a-statistical-symptomatic-evaluation-on-sapho-syndrome-from-56-cases-of-confirmed-diagnosis-and-352-cases-of-non-sapho-involvement
#24
JOURNAL ARTICLE
Cheng Qiu, Manyu Li, Qingrong Wu, Jian Zhou, Tianyi Liu, Jinghang Li, Jingwei Liu, Lin Cheng, Yu Hong, Dan Luo, Jun Yan, Wenping Pan, Zhankui Wang, Qing Wang, Xinyu Liu, Lianlei Wang
OBJECTIVE: To report a statistical evaluation of symptomatology based on 56 cases of SAPHO syndrome and 352 non-SAPHO involvement cases, to propose a symptomatic scoring system in consideration of early warning for SAPHO syndrome. METHODS: A cohort comprising 56 subjects diagnosed with SAPHO syndrome was reported, as well as 352 non-SAPHO involvement cases, including their chief complaints, skin manifestations, radiological findings, and laboratory tests. We systematically reviewed previous published five representative huge cohorts from different countries to conclude several specific features of SAPHO by comparing with our case series...
March 6, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38443604/increased-carotid-intima-media-thickness-in-patients-with-radiographic-axial-spondyloarthritis-compared-to-controls-and-associations-with-markers-of-inflammation
#25
JOURNAL ARTICLE
Lucy Law, Per Lindqvist, Per Liv, Urban Hellman, Kristina Lejon, Mats Geijer, Stefan Söderberg, Helena Forsblad-d'Elia
OBJECTIVE: There is an increased risk for cardiovascular disease (CVD) in patients with radiographic axial spondyloarthritis (r-axSpA). In this cross-sectional study, we aimed to, overall and stratified by sex, (i) compare ultrasound derived carotid intima media thickness (cIMT), between patients and controls, and (ii) investigate associations between cIMT, clinical disease activity and inflammation-related laboratory markers in patients with r-axSpA. METHOD: In total, 155 patients diagnosed with r-axSpA using the modified New York criteria and 400 controls were included...
March 6, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38443603/anti-tumor-necrosis-factor-atnf-weaning-strategy-in-juvenile-idiopathic-arthritis-jia-does-duration-matter
#26
JOURNAL ARTICLE
Kai Liang Teh, Lena Das, Yun Xin Book, Sook Fun Hoh, Xiaocong Gao, Thaschawee Arkachaisri
BACKGROUND: To compare outcomes of a short and long weaning strategy of anti-tumor necrosis factor (aTNF) in our prospective juvenile idiopathic arthritis (JIA) cohort. RESEARCH DESIGN AND METHODS: JIA patients on subcutaneous adalimumab with at least 6 months of follow-up were recruited (May 2010-Jan 2022). Once clinical remission on medication (CRM) was achieved, adalimumab was weaned according to two protocols-short (every 4-weekly for 6 months and stopped) and long (extending dosing interval by 2 weeks for three cycles until 12-weekly intervals and thereafter stopped) protocols...
March 5, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38436771/mendelian-randomization-study-on-causal-association-of-fam210b-with-drug-induced-lupus
#27
JOURNAL ARTICLE
Yaqi Xu, Ran Gao, Min Zhang, Qi Zeng, Shan Zhou, Gaizhi Zhu, Wenting Su, Renxi Wang
OBJECTIVE: Due to the complexity of drug-induced lupus (DIL) pathogenesis, more susceptibility factors need to be discovered. FAM210B is a new mitochondrial protein whose function has not been fully elucidated. This study will explore whether there is a correlation between FAM210B and the risk of DIL. METHODS: At first, we extracted three FAM210B genetic variants from the GTEx database (n = 948), and extracted their corresponding genome-wide association study (GWAS) summary statistics from DIL (101 DIL cases and 218691 controls)...
March 4, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38436770/loss-of-opportunities-in-the-diagnosis-and-treatment-of-primary-obstetric-antiphospholipid-syndrome-poaps-from-theory-to-reality
#28
JOURNAL ARTICLE
Sebastián Udry, José O Latino, Stephanie Morales Perez, Cristina Belizna, Federico Aranda, Enrique Esteve-Valverde, Silvia Perés Wingeyer, Diego S Fernández Romero, Jaume Alijotas-Reig, Gabriela de Larrañaga
OBJECTIVES: (I) To identify and measure the clinical consequences of a delayed diagnosis in patients with primary obstetric antiphospholipid syndrome (POAPS), in terms of time and events associated to antiphospholipid syndrome (APS), and (II) to evaluate the impact of their treatment status on perinatal outcomes, before and after diagnosis. METHODS: This retrospective multicentre study included 99 POAPS women who were separated in two groups of timelines based on their diagnostic status: group 1: women who met the clinical criteria for POAPS; group 2: included the same patients from group 1 since they meet the laboratory criteria for APS...
March 4, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38436769/immune-profiling-analysis-of-double-negative-t-cells-in-patients-with-systemic-sclerosis
#29
JOURNAL ARTICLE
Dongdong Zhang, Mihribangvl Alip, Hongzhen Chen, Dan Wu, Huimin Zhu, Yichen Han, Xinran Yuan, Xuebing Feng, Lingyun Sun, Dandan Wang
OBJECTIVE: To construct a molecular immune map of patients with systemic sclerosis (SSc) by mass flow cytometry, and compare the number and molecular expression of double-negative T (DNT) cell subsets between patients and healthy controls (HC). METHODS: Peripheral blood mononuclear cells (PBMCs) were extracted from the peripheral blood of 17 SSc patients and 9 HC. A 42-channel panel was set up to perform mass cytometry by time of flight (CyTOF) analysis for DNT subgroups...
March 4, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38433147/geriatric-nutrition-risk-index-a-more-powerful-index-identifying-muscle-mass-loss-in-patients-with-rheumatoid-arthritis
#30
JOURNAL ARTICLE
Jie Pan, Tao Wu, Jian-Da Ma, Pei-Wen Jia, Yao-Wei Zou, Zhi-Ming Ouyang, Hu-Wei Zheng, Jian-Zi Lin, Qian Zhang, Ye Lu, Le-Feng Chen, Ze-Hong Yang, Ying-Ying Zhu, Qing-Yang Song, Yun Su, Lin-Wang Su, Wei Dai, Jun Dai, Lie Dai
OBJECTIVE: To explore the association of geriatric nutrition risk index (GNRI), a traditional albumin-body weight calculation, with myopenia in patients with rheumatoid arthritis (RA) and compare its ability to identify myopenia with protein indicators. METHODS: This cross-sectional study was carried out based on a Chinese RA cohort. Clinical data and protein indicators (including albumin, globulin, albumin to globulin ratio, prealbumin, hemoglobin) were collected...
March 4, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38430376/il-6-receptor-inhibition-is-not-associated-with-body-weight-or-composition-mendelian-randomisation-study
#31
LETTER
Sizheng Steven Zhao
No abstract text is available yet for this article.
March 2, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38416306/anca-associated-vasculitis-presenting-with-isolated-neurological-manifestations-in-a-patient-with-cocaine-abuse-a-case-report-and-literature-review
#32
REVIEW
Fazila Aseem, Victor Lin, Abigail L Gilbert, Alfredo C Rivadeneira, J Charles Jennette, Thomas W Bouldin, Freshta Khoshbakht, Yueh Z Lee, Kelly Chamberlin, Aaron Gelinne, Anahit C Mehrabyan, Bushra Javed, Irena Dujmovic Basuroski, Monica M Diaz
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of rare conditions predominantly affecting small vessels of skin, musculoskeletal, pulmonary, renal, and rarely central and peripheral nervous systems. Isolated neurological manifestations of AAV are uncommon and challenging to diagnose. Cocaine has been reported as a potential trigger for the development of AAV. There are only a few case reports of isolated neurological involvement in cocaine-induced AAV with poorly characterized histopathological features...
February 28, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38409491/evaluation-of-type-2-sle-symptoms-in-patients-with-a-range-of-lupus-nephritis-activity
#33
JOURNAL ARTICLE
Jennifer L Rogers, Megan E B Clowse, David S Pisetsky, Lisa G Criscione-Schreiber, Kai Sun, Rebecca E Sadun, Mithu Maheswaranathan, Dana R Burshell, Jayanth Doss, Amanda M Eudy
BACKGROUND: Type 2 systemic lupus erythematosus (SLE) symptoms, including fatigue, fibromyalgia, and brain fog, contribute to poor health-related quality of life (HRQoL) in patients with lupus. To test the hypothesis that Type 1 (classical inflammatory lupus) activity is associated with Type 2 SLE activity, we characterized the features of Type 2 SLE in patients with a range of lupus nephritis (LN) activity. METHODS: This was a cross-sectional study of SLE patients [American College of Rheumatology (ACR) 1997 or Systemic Lupus International Collaborating Clinics (SLICC) 2012 classification criteria] from June 2018 to March 2020...
February 26, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38407714/recurrent-miscarriage-and-low-titer-antiphospholipid-antibodies
#34
JOURNAL ARTICLE
Jian Chen, Jing Yue, Yu Lu, Ting Li, Xue Li, Jian-Yu Zhang
OBJECTIVE: To evaluate the clinical features and pregnancy outcomes in patients experiencing recurrent miscarriage (RM) with either low-titer or medium-high titer positivity of antiphospholipid antibodies (aPL). METHODS: A retrospective review of medical records was conducted for patients with aPL positivity and recurrent miscarriage between 2018 and 2022. The clinical features, treatment strategies, outcomes were compared between the patients with low (n = 92) and medium (n = 32) titer of aPL...
February 26, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38407713/asymmetric-darkened-knuckles-with-subclinical-myopathy-revealed-anti-mi2b-positive-dermatomyositis
#35
EDITORIAL
Ritasman Baisya
No abstract text is available yet for this article.
February 26, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38393545/real-respiratory-infection-risk-in%C3%A2-primary-sj%C3%A3-gren-s-syndrome-complicated-with%C3%A2-interstitial-lung-disease
#36
LETTER
Youjun Xie, Hongying Zhao
No abstract text is available yet for this article.
February 23, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38393544/commentary-on-the-factors-with-liver-fibrosis-in-rheumatoid-arthritis-patients-treated-with-methotrexate
#37
LETTER
Difeng Chen, Junwu Zhang
No abstract text is available yet for this article.
February 23, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38393543/commentary-on-the-respiratory-infection-risk-in-primary-sj%C3%A3-gren-s-syndrome-complicated-with-interstitial-lung-disease
#38
LETTER
Wenchu Dai, Hongfeng He
No abstract text is available yet for this article.
February 23, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38393542/regarding-the-association-between-innate-immune-function-with-disease-activity-in-systemic-lupus-erythematosus-patients
#39
LETTER
Wenchu Dai, Hongfeng He
No abstract text is available yet for this article.
February 23, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38386127/increased-inferior-vena-cava-wall-thickness-as-a-sign-of-extensive-venous-inflammation-in-beh%C3%A3-et-s-disease
#40
JOURNAL ARTICLE
Seda Kutluğ Ağaçkıran, Murat Sünbül, Zekeriya Doğan, Haner Direskeneli, Fatma Alibaz-Oner
INTRODUCTION/OBJECTIVES: Behçet's disease (BD) affects both arterial and venous vessels. We have previously shown that common femoral vein wall thickness (WT) is increased in BD and can be used as a diagnostic test. However, there is limited data assessing large veins. Therefore, this study seeks to assess inferior vena cava wall thickness (IVC) by transthoracic echocardiography (TTE) in BD compared to healthy controls (HC). METHODS: Age- and gender-matched 70 BD patients and 51 HC were included...
February 22, 2024: Clinical Rheumatology
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