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Clinical Rheumatology

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https://www.readbyqxmd.com/read/29139030/potential-risk-factors-for-reactive-arthritis-and-persistence-of-symptoms-at-2%C3%A2-years-a-case-control-study-with-longitudinal-follow-up
#1
Helga Raquel Garcia Ferrer, Alexander Azan, Isa Iraheta, Joan Von Feldt, Luis R Espinoza, Julia Manasson, Jose U Scher, Abraham Garcia Kutzbach, Alexis Ogdie
The objective of the study is to determine the risk factors for the development of reactive arthritis (ReA) and examine the factors associated with the persistence of symptoms. Patients with a new diagnosis of ReA and controls with a gastrointestinal (GI), urogenital, or sexually transmitted infection in the 3-6 months prior to study entry were prospectively enrolled in Guatemala City. ReA patients fulfilled the Assessment in Spondyloarthritis International Society criteria for peripheral spondyloarthropathy (SpA)...
November 14, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29134513/current-concepts-and-unmet-needs-in-psoriatic-arthritis
#2
Farrouq Mahmood, Laura C Coates, Philip S Helliwell
Psoriatic arthritis is a chronic inflammatory arthritis that is part of the spondyloarthropathy group of rheumatic diseases and has associated co-morbidities. It can present with various clinical manifestations making diagnosis and treatment challenging, resulting in significant disability and reduced quality of life for patients. Whilst there have been advances in understanding the pathogenic mechanisms of the disease which have resulted in targeted therapies, there is still the need for further studies as some patients fail or are intolerant of current therapies...
November 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29134512/artery-compliance-in-patients-with-rheumatoid-arthritis-results-from-a-case-control-study
#3
Lei Wang, Wenfeng Tan, Fang Wang, Youxuan Shen, Huanping Mei, Yanyan Wang, Yao Ke, Lei Gu, Qiang Wang, Miaojia Zhang
Atherosclerosis is one of the most common complications of rheumatoid arthritis (RA). The objective of this study is to evaluate differences in large artery compliance (C1) and small artery compliance (C2) between RA and controls and evaluating factors associated with reduced compliance in the RA population. The profiling of large and small arterial compliance was analyzed in 185 RA patients and 88 healthy controls using Cardiovascular Profiling Instrument. The correlations of arterial compliance and the relevant clinical data were determined in these subjects...
November 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29134511/correction-to-rarely-occurring-mutation-of-acvr1-gene-in-moroccan-patient-with-fibrodysplasia-ossificans-progressiva
#4
Ilham Ratbi, Renata Bocciardi, Asmaa Regragui, Roberto Ravazzolo, Abdelaziz Sefiani
One of the author's name on this article was incorrectly spelled as "Renata Borcciadi". The correct spelling is "Renata Bocciardi" and is now presented correctly in this article.
November 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29130141/sj%C3%A3-gren-s-syndrome-initially-presented-as-thrombotic-thrombocytopenic-purpura-in-a-male-patient-a-case-report-and-literature-review
#5
REVIEW
Xiaohan Xu, Tienan Zhu, Di Wu, Lu Zhang
Thrombotic thrombocytopenic purpura (TTP) is a potentially lethal multisystem disorder which could be caused by autoimmune diseases. However, the concomitant occurrence of TTP and Sjögren's syndrome (SS) is an extremely uncommon scenario, especially in male patients. A 56-year-old Chinese male was admitted for the appearance of diffuse ecchymosis. Then he gradually developed transient slurred speech, progressive confusion, agitation, extremity weakness, and fever. Laboratory investigations suggested anemia, thrombocytopenia, significantly increased lactic dehydrogenase, schistocytes in peripheral blood smear, and a disintegrin-like metalloproteinase with thrombospondin motif type 1 member 13 (ADAMTS13) activity deficiency with high inhibitor titers...
November 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29129009/irak2-is-associated-with-susceptibility-to-rheumatoid-arthritis
#6
Hana Ben Hassine, Rim Sghiri, Elyes Chabchoub, Asma Boumiza, Foued Slama, Khadija Baccouche, Zahid Shakoor, Adel Almogren, Christina Mariaselvam, Ryad Tamouza, Elyes Bouajina, Ramzi Zemni
This study was performed to investigate the association of the single nucleotide polymorphisms of interleukin-1 receptor-associated kinase 2 (IRAK2) rs3844283 and rs708035 with rheumatoid arthritis (RA). IRAK2 rs3844283 and rs708035genotyping was determined by mutagenically separated PCR with specifically designed primers in a cohort of 222 (30 men, 192 women, mean age 49 years) adult RA patients and 224 matched controls. IRAK2 rs3844283 C allele was detected in 66% of RA patients and 74% of controls. The CC genotype was the most frequent genotype in both RA patients (45...
November 11, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29129008/high-levels-of-oxidized-fatty-acids-in-hdl-are-associated-with-impaired-hdl-function-in-patients-with-active-rheumatoid-arthritis
#7
Christina Charles-Schoeman, David Meriwether, Yuen Yin Lee, Ani Shahbazian, Srinivasa T Reddy
The objective of this study was to evaluate oxidation products of arachidonic acid and linoleic acid in lipoproteins and synovial fluid (SF) from patients with active rheumatoid arthritis (RA) compared to non-RA controls. High-density lipoproteins (HDL) and low-density lipoproteins (LDL) were isolated from plasma using fast protein liquid chromatography and HDL was isolated from SF using dextran sulfate precipitation. 5-Hydroxyeicosatetraenoic acid (HETE), 12-HETE, 15-HETE, 9 hydroxyoctadecadienoic (HODE), and 13-HODE levels were measured in HDL, LDL, and SF by liquid chromatography-tandem mass spectrometry...
November 11, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29127544/a-brazilian-family-with-inclusion-body-myopathy-associated-with-paget-s-disease-of-bone-and-frontotemporal-dementia-linked-to-the-vcp-pgly97glu-mutation
#8
REVIEW
Samuel Katsuyuki Shinjo, Sueli Mieko Oba-Shinjo, Antonio Marcondes Lerario, Suely Kazue Nagahashi Marie
The objective of this study is to report a Brazilian patient and his family with inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD). A systematic review of the literature on the valosin-containing protein (VCP) mutation was also performed. The proband (patient) was initially treated as a case of possible refractory polymyositis with Paget's disease and later as an inclusion body myopathy. However, after admission to our service, and considering his personal and familial antecedents, whole exome sequencing was performed revealing valosin-containing protein (VCP) c...
November 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29127543/self-efficacy-pain-and-quadriceps-capacity-at-baseline-predict-changes-in-mobility-performance-over-2%C3%A2-years-in-women-with-knee-osteoarthritis
#9
Nicholas M Brisson, Anthony A Gatti, Paul W Stratford, Monica R Maly
This study examined the extent to which baseline measures of quadriceps strength, quadriceps power, knee pain and self-efficacy for functional tasks, and their interactions, predicted 2-year changes in mobility performance (walking, stair ascent, stair descent) in women with knee osteoarthritis. We hypothesized that lesser strength, power and self-efficacy, and higher pain at baseline would each be independently associated with reduced mobility over 2 years, and each of pain and self-efficacy would interact with strength and power in predicting 2-year change in stair-climbing performance...
November 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29119483/low-level-laser-therapy-for-xerostomia-in-primary-sj%C3%A3-gren-s-syndrome-a-randomized-trial
#10
Tania Fidelix, Adriano Czapkowski, Sergio Azjen, Adagmar Andriolo, Pedro Horvath Neto, Virgínia Trevisani
To evaluate the effectiveness of low-level laser therapy (LLLT) in the treatment of xerostomia in primary Sjögren's syndrome (SS), a randomized clinical trial of patients with dry mouth symptoms associated with primary SS receiving care at a university hospital was conducted. Sixty-six patients were randomly assigned with a 1:1 allocation ratio to receive LLLT (laser group, n = 33) or placebo treatment (placebo group, n = 33). Patients in the laser group received LLLT twice a week for 6 weeks, for a total of 12 treatment sessions...
November 9, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29119482/patterns-of-comorbidity-and-disease-characteristics-among-patients-with-ankylosing-spondylitis-a-cross-sectional-study
#11
Lotta Ljung, Björn Sundström, Johan Smeds, Maria Ketonen, Helena Forsblad-d'Elia
The knowledge of the development of comorbidities in patients with ankylosing spondylitis (AS) is limited. The aim of this study was to analyse associations between AS disease characteristics and comorbidity and to evaluate patterns of comorbidities in patients with AS. Patients with AS, fulfilling the modified New York Criteria, were identified (n = 346, mean age 56 ± 15 years, 75% men, 99% HLA B27 positive). Through a review of the patient records, data on disease activity parameters, laboratory results, disease manifestations, and diagnoses of any clinically significant comorbidity was obtained...
November 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29119481/prevalence-of-rheumatoid-cachexia-assessed-by-bioelectrical-impedance-vector-analysis-and-its-relation-with-physical-function
#12
Cira Santillán-Díaz, Noemi Ramírez-Sánchez, Rolando Espinosa-Morales, Arturo Orea-Tejeda, Luis Llorente, Gerardo Rodríguez-Guevara, Lilia Castillo-Martínez
Rheumatoid arthritis (RA) patients frequently have changes in their body composition, with a decrease in muscle mass and an increase in fat mass, a syndrome that is termed rheumatoid cachexia (RC). The prevalence of this nutritional alteration is not well known; there is as yet no consensus, seeing as it depends on the methods, techniques, and cutoff points that are used for its diagnosis. The main aim of this study was to identify RC through assessment by bioelectrical impedance vector analysis (BIVA) and its association with metabolic causes, physical function, and the main disease status, among others...
November 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29119480/rheumatoid-factor-false-positivity-in-patients-with-anca-associated-vasculitis-not-having-medical-conditions-producing-rheumatoid-factor
#13
Jae-Seung Moon, Diane Da-Hyun Lee, Yong-Beom Park, Sang-Won Lee
We investigated the rate of rheumatoid factor (RF) false positivity at diagnosis and its influence on clinical and prognostic features and rheumatoid arthritis (RA) development during the follow-up in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients without RA or other medical conditions triggering RF false positivity. We reviewed the medical records of 128 AAV patients. We divided patients with AAV and each variant into two groups according to RF positivity and compared variables between the two groups...
November 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29119479/utility-of-ct-imaging-in-differentiating-sacroiliitis-associated-with-spondyloarthritis-from-gouty-sacroiliitis-a-retrospective-study
#14
Jyoti Panwar, Pulukool Sandhya, Madhavi Kandagaddala, Aswin Nair, Visalakshi Jeyaseelan, Debashish Danda
Sacroiliitis is one of the criteria for classification as spondyloarthritis (SpA), though not unique to SpA. Other conditions including gout may be erroneously diagnosed as SpA due to sacroiliitis. The objective was to identify specific CT findings in sacroiliitis associated with SpA and gout. In this retrospective study, CT images of patients with sacroiliitis and clinical diagnosis of gout or SpA from 2010 to 2015 were independently reviewed by two radiologists, blinded to diagnosis. Axial and coronal oblique images were analyzed for characteristics of erosions...
November 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29116543/remission-assessment-of-rheumatoid-arthritis-in-daily-practice-in-china-a-cross-sectional-observational-study
#15
Huaqun Zhu, Ru Li, Zhanyun Da, Liqi Bi, Xiangpei Li, Yang Li, Chongyang Liu, Fengxiao Zhang, Zhijun Li, Xiangyuan Liu, Zhiyi Zhang, Lingyun Sun, Youlian Wang, Wei Zhang, Quan Jiang, Jinwei Chen, Qingping Chen, Zhenbin Li, Lijun Wu, Wencheng Qi, Jianhua Xu, Xiangjun Cui, Xiaofei Wang, Long Li, Xiaomei Leng, Guochun Wang, Dongbao Zhao, Lindi Jiang, Dongyi He, Xiaomin Liu, Ling Li, Yongfei Fang, Cibo Huang, Huaxiang Wu, Shaoxian Hu, Qin Li, Hui Song, Weiguo Xiao, Lu Gong, Liaojia Zhang, Xiaofeng Li, Zhanguo Li, Yin Su
The objective of this study is to evaluate the remission rate and describe the current use of medication in a large cohort of rheumatoid arthritis (RA) patients under routine clinical care in China. RA patients were recruited from 40 large teaching hospitals nationwide in China. Data regarding RA disease activity, medication treatment, and adverse events were recorded using a standardized clinical data questionnaire. RA remission was evaluated by the 28 Joint Disease Activity Score DAS28-ESR Clinical Disease Activity Index (CDAI), Simplified Disease Activity Index (SDAI), and American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria...
November 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29116542/the-outcomes-and-risk-factors-of-early-readmission-in-patients-with-intestinal-beh%C3%A3-et-s-disease
#16
Yong Eun Park, Jae Hee Cheon, Yehyun Park, Soo Jung Park, Tae Il Kim, Won Ho Kim
Hospital readmission rate is an integral quality of care measurement for hospitalized patients which is unknown for intestinal Behçet's disease cases. The purpose of this study was to investigate the risk factors and outcomes for patients readmitted early with intestinal Behçet's disease. We retrospectively reviewed patients with intestinal Behçet's disease who were readmitted to our hospital between 2005 and 2016. We then analyzed the risk factors and outcomes for early readmission within 3 months. Of the 204 patients who were readmitted, 103 patients (50...
November 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29116541/a-cross-sectional-study-of-vitamin-d-levels-in-a-large-cohort-of-patients-with-rheumatic-diseases
#17
Elena Nikiphorou, Jaakko Uksila, Tuulikki Sokka
The objective of this study is to examine 25-hydroxyvitamin D [25(OH)D] (D-25) levels and associations with patient- and disease-related factors in rheumatic diseases. This is a register-based study of D-25 levels in adult patients seen at the Central Finland Hospital rheumatology clinic (January 2011-April 2015). Demographic, clinical, laboratory, and patient-reported outcomes (PROs) were collected as part of the normal infrastructure of the outpatient clinic and examined for their association with D-25 level...
November 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29110110/changes-and-clinical-significance-of-cd8-cd122-t-cells-in-the-peripheral-blood-of-patients-with-ankylosing-spondylitis
#18
Renfang Han, Xiao Yang, Mengya Chen, Xu Zhang, Yaping Yuan, Xingxing Hu, Mengmeng Wang, Rui Liu, Yubo Ma, Jiajia Yang, Shengqian Xu, Zongwen Shuai, Shanqun Jiang, Faming Pan
The aim of our study was to explore the relationship between circulating T cells and ankylosing spondylitis (AS) and to find the role of the CD8+CD122+ T cells in the pathogenesis and progression of AS. With the method of case-control design, flow cytometry was performed to quantitatively determine the percentage of circulating CD8(+)CD122(+) T cells in peripheral blood mononuclear cells from established AS patients and age- and gender-matched healthy controls. Serum levels of inflammatory cytokines like interleukin-2, interleukin-10, interleukin-15, TGF-β1, and TNF-ɑ were detected by enzyme-linked immunosorbent assay...
November 6, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29110109/can-we-have-an-overall-osteoarthritis-severity-score-for-the-patellofemoral-joint-using-magnetic-resonance-imaging-reliability-and-validity
#19
Sarah Kobayashi, Anthony Peduto, Milena Simic, Marlene Fransen, Kathryn Refshauge, Jean Mah, Evangelos Pappas
This work aimed to assess inter-rater reliability and agreement of a magnetic resonance imaging (MRI)-based Kellgren and Lawrence (K&L) grading for patellofemoral joint osteoarthritis (OA) and to validate it against the MRI Osteoarthritis Knee Score (MOAKS). MRI scans from people aged 45 to 75 years with chronic knee pain participating in a randomised clinical trial evaluating dietary supplements were utilised. Fifty participants were randomly selected and scored using the MRI-based K&L grading using axial and sagittal MRI scans...
November 6, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29103182/clinical-features-outcome-and-associated-factors-for-posterior-reversible-encephalopathy-in-thai-patients-with-systemic-lupus-erythematosus-a-case-control-study
#20
Usanee Damrongpipatkul, Kanokporn Oranratanachai, Nuntana Kasitanon, Salita Wuttiplakorn, Worawit Louthrenoo
Posterior reversible encephalopathy syndrome (PRES) in patients with systemic lupus erythematosus (SLE) has been recognized increasingly. This study aimed to determine the prevalence, clinical features, brain imaging findings, outcomes, and associated factors of PRES in Thai SLE patients. SLE patients with PRES were identified from the lupus cohort of Chiang Mai University. Controls were SLE patients with a hospital number close to and actually had SLE diagnosis within 5 years of the case (case:control ratio = 1:4)...
November 4, 2017: Clinical Rheumatology
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