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Clinical Rheumatology

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https://www.readbyqxmd.com/read/28332010/an-evidence-based-walking-program-among-older-people-with-knee-osteoarthritis-the-pep-participant-exercise-preference-pilot-randomized-controlled-trial
#1
Laurianne Loew, Lucie Brosseau, Glen P Kenny, Natalie Durand-Bush, Stéphane Poitras, Gino De Angelis, George A Wells
Knee osteoarthritis is a common joint problem leading to an increase of pain and a loss of function in older individuals. The main objective of this study was to evaluate if a participant who was randomly assigned to his preferred group improved his adherence to an effective walking program compared to a participant who did not receive his preferred group. This was a 9-month pilot randomized clinical trial, based on a patient treatment preferences design. The 69 eligible participants had a diagnosis of knee osteoarthritis...
March 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28324200/prevalence-and-characterization-of-non-sicca-onset-primary-sj%C3%A3-gren-syndrome-with-interstitial-lung-involvement
#2
Manfredi Andreina, Sebastiani Marco, Cerri Stefania, Cassone Giulia, Bellini Pietrantonio, Della Casa Giovanni, Luppi Fabrizio, Ferri Clodoveo
Primary Sjögren syndrome (pSS)-related interstitial lung disease (ILD) involved about 10-20% of patients. In 20% of cases, ILD can be diagnosed before pSS; anyway, few studies have investigated the frequency of ILD as the first clinically relevant manifestation of pSS, generally referred to retrospective studies. Aim of our prospective study was to describe prevalence, clinical, serological, and instrumental features of non-sicca onset pSS patients with interstitial lung involvement. During a period of 48 months, all consecutive patients diagnosed as pSS were enrolled...
March 21, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28321569/gadolinium-accumulation-after-contrast-enhanced-magnetic-resonance-imaging-what-rheumatologists-should-know
#3
EDITORIAL
Fabio Martino Doniselli, Domenico Albano, Vito Chianca, Marco Amedeo Cimmino, Luca Maria Sconfienza
No abstract text is available yet for this article.
March 20, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28321568/gastrointestinal-and-liver-lesions-in-primary-childhood-sj%C3%A3-gren-syndrome
#4
Yasuyo Kashiwagi, Tatsuro Hatsushika, Norito Tsutsumi, Soken Go, Shigeo Nishimata, Hisashi Kawashima
Sjögren syndrome (SS) is characterized by lymphocytic infiltration of exocrine glands, mainly the lacrimal and salivary glands, leading to keratoconjunctivitis sicca and xerostomia. SS is one of the most common autoimmune rheumatic diseases in adults; however, few cases of primary childhood SS with gastrointestinal and liver lesions have been reported in the literature. We report five cases of primary childhood SS with gastrointestinal and liver lesions. Multiple gastric biopsies in four cases revealed atrophic gastritis in the antrum of the stomach or chronic gastritis...
March 20, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28303359/vitamin-d-deficiency-as-a-risk-factor-for-the-development-of-autoantibodies-in-patients-with-asia-and-silicone-breast-implants-a-cohort-study-and-review-of-the-literature
#5
Maartje J L Colaris, Rene R van der Hulst, Jan Willem Cohen Tervaert
The development of autoimmunity and/or autoimmune diseases is multifactorial. Vitamin D is one of the factors that might play a role. We postulated that both the presence of adjuvants and insufficient levels of vitamin D may result in the development of autoimmunity in patients with autoimmune/inflammatory syndrome induced by adjuvants (ASIA) in relation to silicone implant incompatibility. We measured vitamin D levels in 135 patients with ASIA in relation to silicone implant incompatibility and related findings to the presence of autoantibodies that are commonly used to diagnose systemic autoimmune diseases...
March 17, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28303358/the-effect-of-balneotherapy-on-pain-relief-stiffness-and-physical-function-in-patients-with-osteoarthritis-of-the-knee-a-meta-analysis
#6
Hiromi Matsumoto, Hiroshi Hagino, Kunihiko Hayashi, Yuki Ideno, Takashi Wada, Toru Ogata, Masami Akai, Atsushi Seichi, Tsutomu Iwaya
This meta-analysis was performed to determine the effect of balneotherapy on relieving pain and stiffness and improving physical function, compared to controls, among patients with knee osteoarthritis. We searched electronic databases for eligible studies published from 2004 to December 31, 2016, with language restrictions of English or Japanese. We screened publications in Medline, Embase, Cochrane library, and the Japan Medical Abstracts Society Database using two approaches, MeSH terms and free words. Studies that examined the effect of balneotherapy for treating knee osteoarthritis of a ≥2-week duration were included...
March 16, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28299460/the-placebo-effect-and-its-determinants-in-fibromyalgia-meta-analysis-of-randomised-controlled-trials
#7
Xi Chen, Kun Zou, Natasya Abdullah, Nicola Whiteside, Aliya Sarmanova, Michael Doherty, Weiya Zhang
The aims of this study were to determine whether placebo treatment in randomised controlled trials (RCTs) is effective for fibromyalgia and to identify possible determinants of the magnitude of any such placebo effect. A systematic literature search was undertaken for RCTs in people with fibromyalgia that included a placebo and/or a no-treatment (observation only or waiting list) control group. Placebo effect size (ES) for pain and other outcomes was measured as the improvement of each outcome from baseline divided by the standard deviation of the change from baseline...
March 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28293753/cd16-positive-circulating-monocytes-and-fibrotic-manifestations-of-systemic-sclerosis
#8
Alain Lescoat, Valérie Lecureur, Mikael Roussel, Béatrice Ly Sunnaram, Alice Ballerie, Guillaume Coiffier, Stéphane Jouneau, Olivier Fardel, Thierry Fest, Patrick Jégo
The objective of this study is to assess the association of clinical manifestations of systemic sclerosis (SSc) with the absolute count of circulating blood monocyte subpopulations according to their membrane expression of CD16. Forty-eight consecutive patients fulfilling the 2013 ACR/EULAR classification criteria for SSc were included in this cross-sectional study. CD16+ monocyte absolute count was defined by flow cytometry and confronted to the clinical characteristics of SSc patients. Twenty-three healthy donors (HD) were randomly selected for comparison...
March 14, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28289923/tocilizumab-reverses-cerebral-vasculopathy-in-a-patient-with-homozygous-samhd1-mutation
#9
REVIEW
Michael Henrickson, Heng Wang
An auto-inflammatory syndrome consequent to SAMHD1 mutations involves cerebral vasculopathy characterized by multifocal stenosis and aneurysms within large arteries, moyamoya, chronic ischemia, and early-onset strokes (SAMS). While this condition involves the innate immune system, additional clinical features mimic systemic lupus erythematosus. Mutations in this gene can also cause a subset of the rare genetic condition Aicardi-Goutières syndrome. To date, no established therapy successfully prevents disease progression...
March 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28283767/seasonal-variations-of-urate-in-a-swedish-adult-population
#10
Axel Åkerblom, Johanna Helmersson-Karlqvist, Tomas Weitoft, Anders Larsson
Seasonality in the incidence and prevalence of gout has previously been reported but the cause of this seasonality in gout is not explained. The aim of this study was to evaluate possible seasonal variations of urate in a large unselected Swedish adult population. We analyzed 170,915 urate test results from patients at a tertiary care hospital between 2000 and 2016. The results were divided according to sex and sampling month of the year. The median urate values were overall higher in males compared to females and both males and females had peak urate concentrations in the summer months (June-August)...
March 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28283766/autoantibodies-to-types-i-and-iv-collagen-and-heart-valve-disease-in-systemic-lupus-erythematosus-antiphospholipid-syndrome
#11
José Pardos-Gea, Josefina Cortés-Hernández, Jesus Castro-Marrero, Eva Balada, José Ordi-Ros
Introduction/objectives autoantibodies to types I and IV collagen have been described in rheumatic fever and infective endocarditis. We tried to elucidate if an autoimmune response against collagens I and IV exists, associated with heart valve disease in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). A cohort of 172 patients with SLE (n = 79), primary APS (PAPS, n = 83), and secondary APS (n = 10) were assessed for valvulopathy by transthoracic echocardiograms. Autoantibodies to types I and IV collagen were assessed in patients and 50 controls, setting autoantibody positivity at two standard deviations above the mean antibody level of controls...
March 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28255740/-isn-t-it-ironic-beliefs-about-the-unacceptability-of-emotions-and-emotional-suppression-relate-to-worse-outcomes-in-fibromyalgia
#12
Hannah Bowers, Abigail L Wroe, Tamar Pincus
Beliefs about the unacceptability of experiencing and expressing emotions have been found to be related to worse outcomes in people with persistent physical symptoms. The current study tested mediation models regarding emotional suppression, beliefs about emotions, support-seeking and global impact in fibromyalgia. One hundred eighty-two participants took part in an online questionnaire testing potential mechanisms of this relationship using mediation analysis. The model tested emotional suppression and affective distress as serial mediators of the relationship between beliefs about emotions and global impact...
March 2, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28255739/are-abatacept-and-tocilizumab-intravenous-users-willing-to-switch-for-the-subcutaneous-route-of-administration-a-questionnaire-based-study
#13
Marie Desplats, Tristan Pascart, Germain Jelin, Laurène Norberciak, Peggy Philippe, Eric Houvenagel, Vincent Goeb, René-Marc Flipo
Choosing the subcutaneous (SC) route of administration of abatacept and tocilizumab is more cost-effective than the intravenous (IV) route. The objective of this study was to examine patients' reasons for choosing to keep with their IV infusions or to switch to subcutaneous SC injections. This study was based upon a self-administered questionnaire given to consecutive rheumatoid arthritis patients treated with abatacept or tocilizumab. Patients were asked to express their opinions concerning reasons explaining why they chose to keep the IV route or switch to the SC route...
March 2, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28251392/a-window-of-opportunity-for-abatacept-in-ra-is-disease-duration-an-independent-predictor-of-low-disease-activity-remission-in-clinical-practice
#14
Leslie R Harrold, Heather J Litman, Sean E Connolly, Sheila Kelly, Winnie Hua, Evo Alemao, Lisa Rosenblatt, Sabrina Rebello, Joel M Kremer
The objective of the study was to examine whether disease duration independently predicts treatment response among biologic-naïve patients with rheumatoid arthritis (RA) initiating abatacept in clinical practice. Using the Corrona RA registry (February 2006-January 2015), biologic-naïve patients with RA initiating abatacept with 12-month (±3 months) follow-up and assessment of disease activity (Clinical Disease Activity Index [CDAI]) at initiation and at 12 months were identified. The primary outcome was mean change in CDAI (ΔCDAI) from baseline to 12 months...
March 1, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28247163/the-profile-of-polyunsaturated-fatty-acids-in-juvenile-idiopathic-arthritis-and-association-with-disease-activity
#15
Daiva Gorczyca, Jacek Postępski, Aleksandra Czajkowska, Mariola Paściak, Anna Prescha, Edyta Olesińska, Anna Gruenpeter, Iwona Lachór-Motyka, Bogumiła Szponar
We investigated the association between dietary intake of n-3 and n-6 polyunsaturated fatty acids (PUFAs), serum profiles, and immune and inflammatory markers in juvenile idiopathic arthritis (JIA) in relation to onset, activity, and duration. A total of 66 JIA patients and 42 controls were included. Serum PUFA levels were assessed by gas-liquid chromatography-mass spectrometry, a dietary intake by 7-day dietary record method, and IL-6, IL-10, and IL-17A levels using ELISA. Dietary PUFA intake did not differ between the JIA group and controls...
February 28, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28243760/switching-profiles-in-a-population-based-cohort-of-rheumatoid-arthritis-receiving-biologic-therapy-results-from-the-kobio-registry
#16
Dong-Jin Park, Sung Jae Choi, Kichul Shin, Hyoun-Ah Kim, Yong-Beom Park, Seong Wook Kang, Seung-Ki Kwok, Seong-Kyu Kim, Eon Jeong Nam, Yoon-Kyoung Sung, Jaejoon Lee, Chang Hoon Lee, Chan Hong Jeon, Shin-Seok Lee
Despite improved quality of care for rheumatoid arthritis (RA) patients, many still experience treatment failure with a biologic agent and eventually switch to another biologic agent. We investigated patterns of biologic treatment and reasons for switching biologics in patients with RA. Patients with RA who had started on a biologic agent or had switched to another biologic agent were identified from the prospective observational Korean nationwide Biologics (KOBIO) registry. The KOBIO registry contained 1184 patients with RA at the time of initiation or switching of biologic agents...
February 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28243759/did-king-herod-suffer-from-a-rheumatic-disease
#17
Cianna Leatherwood, Richard S Panush
Herod the Great was appointed "king of Jews," to govern Judea, by the Roman Emperor and Senate. He lived from 73/74 BCE to 4 CE. He died with an illness and symptoms that have been the source of considerable speculation. Richard Strauss depicted Herod in his classic opera, "Salome." That opera was derived from a play of the same name by Oscar Wilde, which was based on an 1876 painting, "Salome Dancing Before Herod," by Gustave Moreau. The operatic Herod was afflicted with an illness characterized by dementia, hallucinations, paranoia, alcoholism (from drinking the Emperor's wine), violence, twitches, and sterility; different interpretations showed him also with falls, chills, shaking, thirst, forgetfulness, and sleepiness, for which we suggest the novel diagnosis of chronic lead intoxication (which can manifest to rheumatologists as saturnine gout)...
February 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28238088/prevalence-of-resting-ecg-abnormalities-in-systemic-lupus-erythematosus-a-single-center-experience
#18
Gihyun Myung, Lindsy J Forbess, Mariko L Ishimori, Sumeet Chugh, Daniel Wallace, Michael H Weisman
Cardiovascular complications are a major cause of morbidity and even mortality among systemic lupus erythematosus (SLE) patients. Whether cardiac arrhythmias contribute to this burden among SLE patients, however, is not currently known. The goal of this study was to determine the prevalence of cardiac conduction abnormalities among SLE patients from a single center. We retrospectively reviewed the medical records of SLE patients who had 12-lead electrocardiograms (ECGs) available from various settings at a single academic center over the period of 10 years...
February 25, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28238087/bone-regeneration-in-the-stem-cell-era-safe-play-for-the-patient
#19
Estella Musacchio, Nicola Veronese
The past decade has seen outstanding scientific progress in the field of stem cell (SC) research and clinical application. SCs are convenient both technically and biologically: they are easy to find and to culture and they can differentiate in virtually all tissues and even in whole organs. Induced pluripotent stem cells (iPSs) are a type of pluripotent SC generated in vitro directly from mature cells through the introduction of key transcription factors. The use of iPSs, however tantalizing, poses serious safety concerns because of their genomic instability...
February 25, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28238086/misalignment-between-physicians-and-patient-satisfaction-with-psoriatic-arthritis-disease-control
#20
Daniel E Furst, Melody Tran, Emma Sullivan, James Pike, James Piercy, Vivian Herrera, Jacqueline B Palmer
The main objective of the present study is to evaluate the misalignment between psoriatic arthritis (PsA) patient- and physician-reported satisfaction with PsA control. Data came from the Adelphi Rheumatology Disease Specific Programme, a retrospective, cross-sectional survey of US-based rheumatologists and patients. Physicians provided satisfaction and clinical characteristics on tender joint count, swollen joint count, and percent body surface area (BSA) affected by psoriasis. Patients provided data on satisfaction, the Work Productivity Activity Impairment and Health Assessment Questionnaire-Disability Index (HAQ-DI) questionnaires...
February 25, 2017: Clinical Rheumatology
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