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Clinical Rheumatology

Wenjia Sun, Lizhen Tian, Lichun Jiang, Songzhao Zhang, Meiju Zhou, Jianing Zhu, Jing Xue
OBJECTIVE: To determine the serum levels of Dickkopf-1 (DKK-1) and sclerostin, as well as their correlations with the structural damage assessed by modified stoke ankylosing spondylitis spine score (mSASSS) and the disease activity evaluated by ankylosing spondylitis disease activity score (ASDAS) in patients with ankylosing spondylitis (AS). METHODS: Eighty-eight AS patients, 26 rheumatoid arthritis (RA) patients, and 26 age- and gender-matched healthy controls (HC) were collected from rheumatic clinic of the Second Affiliated Hospital of Zhejiang University, School of Medicine, between March 2015 and July 2015...
November 15, 2018: Clinical Rheumatology
Konstantinos Tselios, Kristy Su-Ying Yap, Rattapol Pakchotanon, Ari Polachek, Jiandong Su, Murray B Urowitz, Dafna D Gladman
Prof. Ari Polachek on of the author of the published version of this article missed to add his second affiliation which is the Department of Rheumatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. The new affiliation is now added and presented correctly in this article.
November 14, 2018: Clinical Rheumatology
Minfang Zhang, Chaojun Qi, Yan Zha, Jian Chen, Ping Luo, Li Wang, Zhuxing Sun, Jianxin Wan, Changying Xing, Song Wang, Gengru Jiang, Mindan Sun, Qinkai Chen, Jianghua Chen, Detian Li, Tianjun Guan, Zhaohui Ni
OBJECTIVES: A prospective, multi-center, randomized controlled study was conducted to evaluate the efficacy and safety of a 24-week course low-dose leflunomide combined with prednisone in the induction treatment of proliferative lupus nephritis in Chinese patients. METHOD: Patients (n = 100) with biopsy-proved proliferative lupus nephritis were enrolled in this study. They were randomized into two groups and received either leflunomide or cyclophosphamide in conjunction with prednisone for 24 weeks...
November 13, 2018: Clinical Rheumatology
Laura Bazzichi, Francesca Nacci, Luigi Sinigaglia, Laura Bianchino, Roberto Caporali
To assess, in a setting close to real life, the efficacy and safety of weekly subcutaneous tocilizumab (TCZ-SC) 162 mg, alone or with a conventional synthetic DMARD (csDMARD), in moderate-to-severe RA patients with inadequate response to DMARDs or anti-TNFα drugs. This national, multicenter, open-label, phase IIIb trial is part of an umbrella study (TOZURA). Patients were treated for 52 weeks followed by 8 weeks drug-free to evaluate immunogenicity. The primary end point was the Clinical Disease Activity Index (CDAI) change from baseline at weeks 2 and 24...
November 12, 2018: Clinical Rheumatology
Grace H Lo, Jing Song, Timothy E McAlindon, Gillian A Hawker, Jeffrey B Driban, Lori Lyn Price, Charles B Eaton, Marc C Hochberg, Rebecca D Jackson, C Kent Kwoh, Michael C Nevitt, Dorothy D Dunlop
OBJECTIVE: Validation of a symptom measure for early knee OA may help identify new treatments and modifiable risk factors. Symptom measures that consider pain in the context of activity level may provide better discrimination than pain alone. Therefore, we aimed to compare sensitivity to change for radiographic progression between Ambulation Adjusted Score for Knee pain (AASK), which accounts for self-reported ambulation, and Western Ontario McMaster Osteoarthritis (WOMAC) knee pain score...
November 12, 2018: Clinical Rheumatology
Oreste Corrales, Laura Hernández, Dinorah Prada, Jorge Gómez, Yusimy Reyes, Ana Marta López, Luis Javier González, Maria Del Carmen Domínguez Horta
Rheumatoid arthritis (RA) is a chronic T cell-mediated autoimmune disease. Serum autoantibodies against cyclic citrullinated peptides (anti-CCP) are significant markers for diagnosis and prognosis of this disease. Induction of immune tolerance as therapeutic approach for RA constitutes a current research focal point. In this sense, we carried out a phase I clinical trial in RA patients with a new therapeutic candidate (called CIGB-814); which induced mechanisms associated with restoration of peripheral tolerance in preclinical studies...
November 10, 2018: Clinical Rheumatology
Richard Seto, Lauren M Mathias, Andrew Kelly, Richard S Panush
We cared for a woman with sero-positive rheumatoid arthritis (RA), in clinical remission on oral methotrexate (MTX) and hydroxychloroquine, who wished to donate a kidney to a brother with end-stage renal disease (ESRD). We could find scant literature about this unusual clinical circumstance, and therefore review pertinent aspects of renal disease in RA, perioperative medical management, maintenance of disease remission, outcomes for RA patients who have donated kidneys, and relevant ethical issues. Renal complications in RA are not uncommon, with as many as 50% of patients at risk of reduced eGFR...
November 8, 2018: Clinical Rheumatology
Yuichi Yamasaki, Syuji Takei, Hiroyuki Imanaka, Tomohiro Kubota, Yukiko Nonaka, Tomoko Takezaki, Yoshifumi Kawano
OBJECTIVES: Systemic juvenile idiopathic arthritis (sJIA) has recently become regarded as one of the autoinflammatory syndromes (AIS). However, other AIS, such as familial Mediterranean fever (FMF) and Blau syndrome, have been initially misdiagnosed as sJIA because of the clinical similarities. Making the correct diagnosis in the early stage of these AIS is desirable. Therefore, we evaluated serum S100A12 and vascular endothelial growth factor (VEGF) levels to determine if they could be biomarkers for differentiating these AIS...
November 8, 2018: Clinical Rheumatology
Monika Ponikowska, Jerzy Świerkot, Beata Nowak, Lucyna Korman, Piotr Wiland
OBJECTIVES: The aim of the study was to evaluate the frequency of anti-mutated citrullinated vimentin antibodies (a-Sa), anti-citrullinated α-enolase peptide 1 antibodies (a-CEP-1), anti-filaggrin antibodies (AFAs), heterogeneous nuclear ribonucleoprotein compies/anti-RA33-antibodies (a-hnRNP/RA33), anti-carbamylated protein antibodies (a-CarP), and metalloproteinase (MMPs) activity in patients with early inflammatory arthritis (EIA). METHODS: Seventy-four patients with EIA: 51 diagnosed with RA (rheumatoid arthritis) and 23 with UA (undifferentiated arthritis), and 20 healthy volunteers were enrolled to the study...
November 7, 2018: Clinical Rheumatology
Ana Martínez-Feito, Chamaida Plasencia-Rodríguez, Victoria Navarro-Compán, Borja Hernández-Breijo, María Ángeles González, Irene Monjo, Laura Nuño, Pilar Nozal, Dora Pascual-Salcedo, Alejandro Balsa
To investigate the effect of concomitant conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) with adalimumab or infliximab on maintaining serum drug and clinical outcomes after the first year of treatment in patients with rheumatoid arthritis (RA). Second, to assess the influence of methotrexate (MTX) dose on these outcomes. Ninety-two patients with RA starting infliximab (n = 67) or adalimumab (n = 25) tumor necrosis factor inhibitor (TNFi) with available drug levels and clinical improvement assessment (European League Against Rheumatism [EULAR] response) after 12 months were included...
November 6, 2018: Clinical Rheumatology
Silvia Tamanini, Micaela Fredi, Francesca Crisafulli, Maria Grazia Lazzaroni, Angela Tincani, Franco Franceschini
No abstract text is available yet for this article.
November 5, 2018: Clinical Rheumatology
Cho Hee Bang, Cholhee Kim, Jae-Hoon Kim, Sung Jae Choi, Gwan Gyu Song, Jae Hyun Jung
AIMS: Coffee is one of the most consumed beverages globally, and coffee consumption is increasing. Osteoarthritis (OA), the most common musculoskeletal disease in the elderly, is also becoming more prevalent. Coffee is associated with various diseases, but there has not yet been a study of the relationship between coffee and knee OA. Therefore, we investigated this relationship in elderly Koreans. METHODS: Data from 2012 to 2013 were collected from the Korea National Health and Nutrition Examination Survey...
November 5, 2018: Clinical Rheumatology
Tatiana Cobo-Ibáñez, Francisco-Javier López-Longo, Beatriz Joven, Patricia E Carreira, Santiago Muñoz-Fernández, Valentina Maldonado-Romero, Carmen Larena-Grijalba, Irene Llorente Cubas, Eva Tomero Muriel, Carmen Barbadillo Mateos, Paloma García de la Peña Lefebvre, Alejandro Gomez-Gomez, Laura Barrio Nogal, Ana Pérez, Raquel Almodovar, Leticia Lojo, Lucía Ruiz-Gutiérrez, Juan Carlos López-Robledillo, María Jesús García de Yébenes, Laura Nuño-Nuño
OBJECTIVE: To study prognostic factors in different types of idiopathic inflammatory myopathies (IIM) associated with interstitial lung disease (ILD). PATIENTS AND METHODS: Multicenter retrospective study of a Spanish cohort of patients diagnosed with IIM. Patients were classified into four categories: polymyositis (PM), dermatomyositis (DM), antisynthetase syndrome (ASS), and overlap myositis (OM). Sociodemographic data, clinical characteristics, antibodies, and treatments were collected...
November 3, 2018: Clinical Rheumatology
Rita de Cássia Corrêa Miguel, Luciana Andrade Machado, Luciana Costa-Silva, Rosa Weiss Telles, Sandhi Maria Barreto
OBJECTIVE: To compare the performance of different knee osteoarthritis (OA) classification criteria in a subsample of subjects of ELSA-Brasil Musculoskeletal cohort (ELSA-Brasil MSK) in comparison with the clinical-radiographic evaluation of an experienced rheumatologist. METHOD: A cross-sectional study of the diagnostic accuracy of different knee OA classification criteria: radiographic OA, symptomatic OA, clinical and clinical-radiographic criteria of the American College of Rheumatology (ACR), and the definition proposed by the National Institute for Health and Care Excellence (NICE), UK...
October 31, 2018: Clinical Rheumatology
Heikki Relas, Silja Kosola
OBJECTIVES: Across diagnosis groups, transition of adolescents and young adults from children's hospitals to adult care associates with decreased treatment adherence and suboptimal treatment results. Our aim was to compare the health-related quality of life (HRQoL) and disease activity of juvenile idiopathic arthritis (JIA) patients after the transfer of care to the adult clinic and adult patients in the same outpatient clinic. METHODS: All consecutive JIA patients aged 16 to 20 years who visited the transition clinic between September 2016 and August 2017 and all consecutive adult onset arthritis patients between December 2016 and August 2017 in the rheumatology outpatient clinic of Helsinki University Hospital were evaluated...
October 29, 2018: Clinical Rheumatology
Taghreed G Mousa, Hanan H Omar, Rasha Emad, Mona I Salama, Waleed Omar, Mohamed Fawzy, Howayda M Hassoba
BACKGROUND: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder of unknown etiology. Considerable evidence supports a genetic basis for susceptibility to SLE. Genetic and functional data suggested the CD40 receptor (CD40) and CD40 ligand (CD40L) as strong candidate genes for SLE. AIM: To investigate whether CD40 gene rs1883832 C/T single-nucleotide polymorphism (SNP) and/or soluble CD40 (sCD40) are associated with SLE in the Egyptian population. SUBJECTS AND METHODS: The study included a hundred SLE patients, and a fifty age- and gender-matched healthy control subjects...
October 29, 2018: Clinical Rheumatology
Sinan Kardeş
INTRODUCTION/OBJECTIVE: While few studies with various types of outcomes and methodology have investigated the seasonality of gout, no internet data has been used in any study. This novel methodology may complement and extend the previous traditional data sources and has increasingly been used in investigating the seasonality of health conditions. Therefore, the objective of this study was to utilize the Google Trends data to test whether there is a seasonal variation in the internet searches for gout on a population basis...
October 29, 2018: Clinical Rheumatology
Patricia Corzo, Anna Pros, Juana Martinez-Llorens, Luis Molina, Stephanie Fenxi Ling, Eva Balcells
INTRODUCTION: Diffusing capacity for carbon monoxide (DLco) reduction is the first detectable pulmonary functional test (PFT) change in systemic sclerosis (SSc)-related pulmonary complications. reduction in patients without cardiopulmonary alterations has also been observed; a good characterisation of these patients is lacking. The objective of this study is to describe the characteristics of SSc patients with isolated DLco reduction and compare these patients to SSc patients with DLco reduction with a known cause...
October 27, 2018: Clinical Rheumatology
Hania S Zayed, Basma M Medhat, Esraa M Seif
INTRODUCTION/OBJECTIVES: Despite its importance, adherence to treatment has not been sufficiently studied in Behçet's disease (BD). The aim of this study was to evaluate medication adherence in BD using the Compliance Questionnaire of Rheumatology (CQR) and factors potentially affecting it. METHOD: This cross-sectional study included 67 consecutive BD patients including 57 (85%) males with a mean age of 35.1 ± 9.27 years and mean disease duration of 129 ± 91 months...
October 26, 2018: Clinical Rheumatology
Phildrich Teh, Bishoy Zakhary, Vaneet K Sandhu
The role of obesity in systemic lupus erythematosus (SLE) remains controversial. Studies have linked adiposity with a heightened risk of clinical complications including neurocognitive decline, renal impairment, dampened physical activity, and depressed quality of life-but not disease activity. We aimed to reexamine whether obesity in SLE patients independently associates with higher disease activity. Adult patients with SLE were recruited from the longitudinal, multi-ethnic Southern California Lupus Registry (SCOLR)...
October 24, 2018: Clinical Rheumatology
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