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Clinical Rheumatology

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https://www.readbyqxmd.com/read/28432524/correlation-of-serum-mmp3-and-other-biomarkers-with-clinical-outcomes-in-patients-with-ankylosing-spondylitis-a-pilot-study
#1
Dongyi He, Qi Zhu, Quan Zhou, Qing Qi, Hongmei Sun, Liza M Zachariah, Grace Wang, John D Reveille, Yongtao Guan, Xiaodong Zhou
The studies aimed to assess a set of biomarkers for their correlations with disease activity/severity of patients with ankylosing spondylitis (AS). A total of 24 AS patients were treated with etanercept and prospectively followed for 12 weeks. Serum levels of TNF-α, IFN-γ, TGF-β, IL6, IL15, IL17, MMP3, and MICA were measured at baseline and after treatment. The change of these biomarkers was analyzed for correlations with MRI indices for joint inflammation, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, AS Disease Activity Score, serum CRP, and ESR...
April 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28432523/hypothesis-free-analyses-from-a-large-psoriatic-arthritis-cohort-support-merger-to-consolidated-peripheral-arthritis-definition-without-subtyping
#2
Daniel Stekhoven, Almut Scherer, Michael J Nissen, Véronique Grobéty, Nikhil Yawalkar, Peter M Villiger, Burkhard Möller
Current ClASsification criteria for Psoriatic ARthritis classification criteria for psoriatic arthritis (PsA) provide a preliminary definition of inflammatory articular disease. This study aimed to further characterize PsA peripheral arthritis using purely data-driven approaches for the affected joint distribution pattern. PsA patients from the Swiss Clinical Quality Management in Rheumatic Diseases (SCQM) database were clustered according to similarities in 66 swollen and in 68 tender joints. Clusters were compared in terms of other disease characteristics and studied for coincidence with traditional PsA subtypes, stability over time and treatment response upon first tumour necrosis factor alpha (TNF-α) therapy...
April 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28432522/diagnostic-uncertainty-and-epistemologic-humility
#3
EDITORIAL
Andrew Kelly, Richard S Panush
No abstract text is available yet for this article.
April 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28424907/the-added-value-of-synovial-fluid-centrifugation-for-monosodium-urate-and-calcium-pyrophosphate-crystal-detection
#4
D Boumans, M E Hettema, H E Vonkeman, R G Maatman, M A van de Laar
The aim of the study was to assess the added value of synovial fluid (SF) centrifugation for microscopic monosodium urate (MSU) and calcium pyrophosphate (CPP) crystal detection in patients with arthritis. This is a prospective observational study using SF samples from joints of patients undergoing joint arthrocentesis. Two blinded observers assessed the SF smears by polarized light microscopy for the presence of crystals before as well as after centrifugation. SF samples were collected from 98 patients with arthritis...
April 19, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28424906/prevalence-and-features-of-metabolic-syndrome-in-childhood-onset-systemic-lupus-erythematosus
#5
Nailú Angélica Sinicato, Mariana Postal, Karina de Oliveira Peliçari, Leticia Rittner, Roberto Marini, Simone Appenzeller
To estimate the prevalence and features of metabolic syndrome (MetS) in childhood-onset systemic lupus erythematosus (cSLE), we performed a cross-sectional study of 76 consecutive cSLE patients and 54 healthy controls, age and sex matched. All individuals were assessed for anthropometric and MetS features according to World Health Organization (WHO), NCEP Adult Treatment Panel III (NCEP-ATP III), and International Diabetes Federation (IDF) criteria. The cSLE patients were further assessed for clinical and laboratory manifestations, disease activity (Systemic Lupus Erythematosus Disease Activity Index), cumulative damage (Systemic Lupus International Collaborating Clinics (SLICC)), and current and cumulative drug exposures...
April 19, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28424905/association-of-stat4-rs7574865-and-ptpn22-rs2476601-polymorphisms-with-rheumatoid-arthritis-and-non-systemically-reacting-antibodies-in-egyptian-patients
#6
Dalia El-Lebedy, Hala Raslan, Alshaymaa Ibrahim, Ingy Ashmawy, Shereen Abd El-Aziz, Asmaa M Mohammed
The aim of this study was to investigate association of protein tyrosine phosphatase non-receptor type 22 (PTPN22) rs2476601 and signal transducer and activator of transcription 4 (STAT4) rs7574865 polymorphisms with rheumatoid arthritis (RA) susceptibility and to assess potential association with the status of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies, serum neopterin, and disease activity. RF, anti-CCP antibodies, and neopterin were assayed in serum of 100 unrelated RA patients and 114 controls...
April 19, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28421363/response-to-dr-hawkes-letter-regarding-hpv-vaccine-serious-adverse-events
#7
LETTER
Manuel Martínez-Lavín
No abstract text is available yet for this article.
April 18, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28409239/macrophage-activation-syndrome-in-systemic-lupus-erythematosus-a-multicenter-case-control-study-in-china
#8
Ai-Chun Liu, Yue Yang, Meng-Tao Li, Yuan Jia, Sheng Chen, Shuang Ye, Xiang-Zong Zeng, Zhao Wang, Jin-Xia Zhao, Xiang-Yuan Liu, Jian Zhu, Yan Zhao, Xiao-Feng Zeng, Zhan-Guo Li
The objective of this study was to describe the clinical and laboratory characteristics, precipitating factors, treatment, and outcome of macrophage activation syndrome (MAS) complicating systemic lupus erythematosus (SLE). A multicenter case-control study was performed across six tertiary hospitals from 1997 to 2014. A total of 32 patients with SLE-associated MAS were enrolled. Sixty-four age- and sex-matched SLE patients diagnosed in the same period without MAS episodes were selected as controls. The most frequent clinical feature was fever, followed by splenomegaly...
April 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28405844/presidents-day-reflections-why-donald-trump-could-not-be-a-rheumatologist
#9
LETTER
Richard S Panush, Eric L Matteson
No abstract text is available yet for this article.
April 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28405843/quality-of-life-of-patients-treated-for-giant-cell-arteritis-a-case-control-study
#10
Stéphanie Jobard, Julie Magnant, Hélène Blasco, Nicole Ferreira-Maldent, Isabelle Griffoul, Elisabeth Diot, François Maillot
The objective of the study was to assess the quality of life (QOL) of patients with giant cell arteritis (GCA), following high dose of corticosteroids (CS). Thirty patients with GCA who had stopped CS or who were under long-term low dose of CS were included and matched to 60 controls. QOL was measured by the SF-36 score and a specific questionnaire. GCA patients had no impairment of QOL compared to controls according to SF-36. Most of them (57%) estimated that their general condition was improved following treatment...
April 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28401434/long-term-efficacy-and-safety-of-golimumab-in-the-treatment-of-multirefractory-beh%C3%A3-et-s-disease
#11
Antonio Vitale, Giacomo Emmi, Giuseppe Lopalco, Claudia Fabiani, Stefano Gentileschi, Elena Silvestri, Di Scala Gerardo, Florenzo Iannone, Bruno Frediani, Mauro Galeazzi, Giovanni Lapadula, Donato Rigante, Luca Cantarini
Our aim was to retrospectively assess the role of golimumab as a treatment choice in patients with Behçet's disease (BD). Seventeen patients diagnosed with BD according to the international criteria were consecutively enrolled; the BD Current Activity Form (BDCAF) was used to evaluate disease activity. After having collected clinical data from patients, statistical analysis was performed to identify differences between the start of therapy and last visit; significance was defined as p < 0.05. The mean duration of golimumab treatment was 18...
April 11, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28397078/elevated-levels-of-tl1a-are-associated-with-disease-activity-in-patients-with-systemic-sclerosis
#12
Wangdong Xu, Linchong Su, Pingying Qing, Ying Wang, Yan Liang, Yi Zhao, Qiongxiu Zhou, Feng Ma, Yi Liu
TL1A is a member of the TNF superfamily. It performs significantly in the pathogenesis of rheumatic and autoimmune diseases partly through regulating the Th17 pathway. The clinical implication of circulating TL1A in patients with systemic sclerosis (SSc) remains unclear, and correlation between TL1A and Th17-related cytokines in the pathogenesis of SSc needs to be discussed. We measured serum levels of TL1A and Th17-related cytokines by ELISA in 47 patients with SSc, 56 patients with SLE, and 53 healthy subjects, and investigated association of these cytokines with clinical manifestations and laboratory variables...
April 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28391592/metabolic-syndrome-in-patients-with-ankylosing-spondylitis-receiving-anti-tnf%C3%AE-therapy-association-with-predictors-of-cardiovascular-risk
#13
Diego Germano Maia, Kristopherson Lustosa Augusto, Mailze Campos Bezerra, Carlos Ewerton Maia Rodrigues
The purposes of this study were to determine the prevalence of metabolic syndrome (MetS) in patients with ankylosing spondylitis (AS) receiving anti-TNFα therapy and evaluate the association of the two conditions with clinical and laboratory findings and predictors of cardiovascular risk. In this cross-sectional study, 63 patients diagnosed with AS according to the modified New York criteria and treated with TNFα blockers and 33 healthy controls were submitted to clinical examination and anthropometric measurements...
April 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28389989/single-vagus-nerve-stimulation-reduces-early-postprandial-c-peptide-levels-but-not-other-hormones-or-postprandial-metabolism
#14
M W Tang, F S van Nierop, F A Koopman, H M Eggink, D M Gerlag, M W Chan, R Zitnik, F M Vaz, J A Romijn, P P Tak, M R Soeters
A recent study in rheumatoid arthritis (RA) patients using electrical vagus nerve stimulation (VNS) to activate the inflammatory reflex has shown promising effects on disease activity. Innervation by the autonomic nerve system might be involved in the regulation of many endocrine and metabolic processes and could therefore theoretically lead to unwanted side effects. Possible effects of VNS on secretion of hormones are currently unknown. Therefore, we evaluated the effects of a single VNS on plasma levels of pituitary hormones and parameters of postprandial metabolism...
April 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28389988/voriconazole-induced-periostitis-vs-hypertrophic-osteoarthropathy
#15
LETTER
Carlos Pineda, Manuel Martínez-Lavín
No abstract text is available yet for this article.
April 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28389987/-hiker-s-feet-a-novel-cutaneous-finding-in-the-inflammatory-myopathies
#16
REVIEW
Jacob T Cox, David M Gullotti, Christopher A Mecoli, Arash H Lahouti, Jemima Albayda, Julie Paik, Cheilonda Johnson, Sonye K Danoff, Andrew L Mammen, Lisa Christopher-Stine
Mechanic's hands is a well-characterized manifestation of select idiopathic inflammatory myopathy (IIM) syndromes. Less well characterized is the hyperkeratosis of the toes and plantar surface of the feet that can also accompany these disorders. We aim to describe common pedal signs in the context of IIM, and suggest that it may be another key feature in the presentation of these syndromes. A cohort of 2145 myositis patient charts gathered since 2003 were retrospectively reviewed using the key search terms "mechanic's feet" and/or "mechanic's foot...
April 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28382403/meaningful-patient-engagement-in-inflammatory-arthritis-development-of-the-patient-motivation-questionnaire
#17
Y El Miedany, Maha El Gaafary, Sally Youssef, Nadia El Aroussy
The objective of this study is to develop a questionnaire for evaluating the patient's "motivation" and assess the psychometric properties of that measure in patients with chronic inflammatory arthritis. Using Rasch analysis and questions item pool, content analysis, and semi-structured group discussion, the questionnaire was developed including 10-item scale (0-10 on VAS scale). Construct validity was assessed by correlating the questionnaire score to parameters of disease activity (DAS-28, ASDAS, and DAPSA scores), functional disability, quality of life, patient self-helplessness measure, as well as the patients' compliance to therapy...
April 5, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28378099/increased-serum-sfas-strail-and-reduced-sfasl-in-juvenile-onset-systemic-lupus-erythematosus
#18
Bernadete L Liphaus, Maria Helena B Kiss, Solange Carrasco, Patrícia Palmeira, Claudia Goldenstein-Schainberg, Magda Carneiro-Sampaio
The aims of this study were to assess serum Fas, FasL, TRAIL, and Bcl-2 levels in patients with juvenile-onset systemic lupus erythematosus (JSLE) and to evaluate their relations with disease activity parameters and nephritis. Forty-eight JSLE patients, 33 juvenile idiopathic arthritis (JIA, inflammatory controls) patients and 40 healthy controls were enrolled. sFas, sFasL, sTRAIL, and sBcl-2 serum levels were measured by ELISA. Disease activity parameters included SLEDAI score, ESR, anti-dsDNA antibodies, C3, and C4 levels...
April 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28378098/association-of-obesity-with-patient-reported-outcomes-in-patients-with-axial-spondyloarthritis-a-cross-sectional-study-in-an-urban-asian-population
#19
Yi Xuan Lee, Yu Heng Kwan, Wan Yu Png, Ka Keat Lim, Chuen Seng Tan, Nai Lee Lui, Eng Hui Chew, Julian Thumboo, Truls Østbye, Warren Fong
To determine if obesity is associated with poorer patient-reported outcomes (PROs) in patients with axial spondyloarthritis (axSpA), we conducted a cross-sectional study using data of the PRESPOND registry from a tertiary referral center in Singapore between 2011 and 2015. Demographics, clinical, and PRO variables were collected. Patients were divided into three categories: normal (BMI < 23 kg/m(2)), overweight (23 kg/m(2) ≤ BMI < 27.5 kg/m(2)) and obese (BMI ≥ 27.5 kg/m(2)), using Asian BMI classification...
April 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28365806/vitamin-d-deficiency-is-associated-with-digital-ulcer-but-not-with-atherosclerosis-or-arterial-stiffness-in-patients-with-systemic-sclerosis-a-pilot-study
#20
Eun-Kyoung Park, Ji-Heh Park, Seong-Min Kweon, Geun-Tae Kim, Seung-Geun Lee
The objective of this study was to investigate the association of vitamin D deficiency with digital ulcers (DUs) that result from microvasculopathy, carotid intima-media thickness (CIMT) as surrogate markers of atherosclerosis, and brachial-ankle pulse wave velocity (baPWV) representing arterial stiffness in patients with systemic sclerosis (SSc). In this cross-sectional study, 40 female SSc patients and 80 healthy controls matched for sex, age, and blood sampling season were recruited. Vitamin D deficiency was defined as serum 25-OHD levels <30 ng/mL...
April 1, 2017: Clinical Rheumatology
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