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Clinical Rheumatology

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https://www.readbyqxmd.com/read/28213786/silica-associated-systemic-sclerosis-in-2017-60%C3%A2-years-after-erasmus-where-do-we-stand
#1
LETTER
Alain Lescoat, Catherine Cavalin, Odile Macchi, Patrick Jégo, Paul-André Rosental
No abstract text is available yet for this article.
February 17, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28210825/recovery-of-nail-dystrophy-potential-new-therapeutic-indication-of-tofacitinib
#2
REVIEW
Jose A Jaller, Juan J Jaller, Antonio M Jaller, Juan J Jaller-Char, Sineida Berbert Ferreira, Rachel Ferreira, Morton Scheinberg
Nail dystrophy is a heterogeneous skin condition and in some subtypes, is associated with autoimmune diseases in particular psoriasis and psoriatic arthritis. In this report, we show that tofacitinib, a novel therapy for rheumatoid arthritis, appears to be beneficial in patients with nail disease refractory to other conventional modes of therapy.
February 16, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28204893/gastrointestinal-system-manifestations-in-juvenile-systemic-lupus-erythematosus
#3
Hafize Emine Sönmez, Asuman Nur Karhan, Ezgi Deniz Batu, Yelda Bilginer, Ersin Gümüş, Hülya Demir, Aysel Yüce, Seza Özen
Systemic lupus erythematosus (SLE) is an autoimmune disease which may involve gastrointestinal system (GIS). The aim of this study was to present GIS manifestations of pediatric SLE patients. The medical files of 69 children with SLE followed between January 2011 and January 2016 were reviewed. All fulfilled the Systemic Lupus International Collaborating Clinics criteria. All patients (≤18 years of age) with GIS manifestations were included. GIS manifestations were observed in 19 (27.5%) out of 69 SLE patients and present at the time of SLE diagnosis in 13 (68...
February 16, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28204892/vaccine-related-serious-adverse-events-might-have-been-under-recognized-in-the-pivotal-hpv-vaccine-randomized-trial
#4
LETTER
Manuel Martínez-Lavín
No abstract text is available yet for this article.
February 16, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28204891/low-titer-isolated-anti-ro-ssa-60-kd-antibodies-is-correlated-with-positive-pregnancy-outcomes-in-women-at-risk-of-congenital-heart-block
#5
Marta Tonello, Ariela Hoxha, Elena Mattia, Alessandra Zambon, Silvia Visentin, Alessia Cerutti, Anna Ghirardello, Ornella Milanesi, Amelia Ruffatti
Congenital heart block (CHB) is an autoantibody mediated disorder presumably caused by placental transmission of maternal autoantibodies to Ro/SSA 52 kd, p200, Ro/SSA 60 kd, La/SSB ribonucleoproteins. This study investigated the clinical significance of isolated anti-Ro/SSA 52 kd, anti-p200, anti-Ro/SSA 60 kd, and anti-La/SSB antibodies in positive pregnant patients. One hundred sixty-three pregnant women positive to anti-Ro/SSA 52 kd and/or anti-Ro/SSA 60 kd and/or anti-La/SSB antibodies were prospectively enrolled in the study...
February 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28194525/low-dose-solumatrix-diclofenac-in-patients-with-osteoarthritis-pain-impact-on-quality-of-life-in-a-controlled-trial
#6
Vibeke Strand, Martin Bergman, Jasvinder A Singh, Allan Gibofsky, Alan Kivitz, Clarence Young
Low-dose SoluMatrix diclofenac was developed to provide effective pain relief for osteoarthritis pain. We evaluated the effects of SoluMatrix diclofenac on health-related quality of life (HRQoL) measures in patients with osteoarthritis, hypothesizing that SoluMatrix-treated patients would experience significant improvement compared with placebo. In this 12-week, phase 3 randomized controlled trial, 305 patients with osteoarthritis of the hip or knee received SoluMatrix diclofenac 35 mg three times (TID) or twice (BID) daily or placebo...
February 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28191607/retrospective-study-of-the-clinical-characteristics-and-risk-factors-of-rheumatoid-arthritis-associated-interstitial-lung-disease
#7
Yongfeng Zhang, Hongbin Li, Nawei Wu, Xin Dong, Yi Zheng
This study aims to explore the clinical characteristics and risk factors of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD). This is a retrospective study of 550 patients with RA. All patients underwent chest high-resolution computed tomography (HRCT) scanning. (1) Two hundred thirty-seven out of five hundred fifty (43.1%) patients with RA were diagnose with ILD. 13.5% ILD occurred before RA onset, 69.6% ILD occurred within 10 years of RA onset, and 16.9% ILD occurred more than 10 years after RA onset...
February 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28191606/translation-and-cross-cultural-adaptation-of-the-shoulder-pain-and-disability-index-spadi-into-chinese
#8
Min Yao, Long Yang, Zuo-Yuan Cao, Shao-Dan Cheng, Shuang-Lin Tian, Yue-Li Sun, Jing Wang, Bao-Ping Xu, Xiao-Chun Hu, Yong-Jun Wang, Ying Zhang, Xue-Jun Cui
The aim of this study is to translate and cross-culturally adapt the Shoulder Pain and Disability Index (SPADI) for the Chinese language, and to evaluate its psychometric properties. The SPADI was translated and cross-culturally adapted for the Chinese language according to established guidelines. Participants completed the SPADI questionnaire, a visual analogue scale (VAS), and the 36-item short form health survey (SF-36), and were assessed using the Constant-Murley shoulder outcome score. Exploratory factor analysis was used to examine the latent dimensions, and Cronbach's α to measure internal consistency...
February 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28190118/receptor-activator-of-nuclear-factor-kappa-b-ligand-rankl-but-not-sclerostin-or-gene-polymorphisms-is-related-to-joint-destruction-in-early-rheumatoid-arthritis
#9
Antonia Boman, Heidi Kokkonen, Lisbeth Ärlestig, Ewa Berglin, Solbritt Rantapää-Dahlqvist
The aim of this study was to analyze relationships between receptor activator of nuclear factor kappa-B (RANKL), sclerostin and their gene polymorphisms with radiological progression in patients with early rheumatoid arthritis (RA). Patients with early RA (n = 407, symptomatic <1 year) (ARA criteria) examined radiologically at inclusion and after 24 months were consecutively included. Disease activity score and C-reactive protein were regularly recorded. Sclerostin, RANKL, and anti-CCP2 antibodies were analyzed in plasma at baseline using ELISAs...
February 11, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28188391/knee-symptoms-among-adults-at-risk-for-accelerated-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#10
Julie Davis, Charles B Eaton, Grace H Lo, Bing Lu, Lori Lyn Price, Timothy E McAlindon, Mary F Barbe, Jeffrey B Driban
The purpose of this study was to examine if adults who develop accelerated knee osteoarthritis (KOA) have greater knee symptoms with certain activities than those with or without incident common KOA. We conducted a case-control study using data from baseline and the first four annual visits of the Osteoarthritis Initiative. Participants had no radiographic KOA at baseline (Kellgren-Lawrence (KL) <2). We classified 3 groups as follows: (1) accelerated KOA: > = 1 knee developed advance-stage KOA (KL = 3 or 4) within 48 months, (2) common KOA: > = 1 knee increased in radiographic severity (excluding those with accelerated KOA), and (3) no KOA: no change in radiographic severity by 48 months...
February 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28188390/acknowledgement-to-referees-2016
#11
(no author information available yet)
No abstract text is available yet for this article.
February 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28185016/association-between-paraoxonase-1-gene-q192r-and-l55m-polymorphisms-in-systemic-lupus-erythematosus-sle-and-anti-phospholipid-syndrome-aps-in-a-population-from-cairo-of-egypt
#12
Alshaymaa Ahmed Ibrahim, Dalia El-Lebedy, Ingy Ashmawy, Maha Abdel Hady
Paraoxonase-1 (PON1) is involved in the oxidative stress process that cause tissue damage observed in systemic lupus erythematosus (SLE) and anti-phospholipid syndrome (APS). The aim of the present study was to investigate the association of PON1 Q192R and L55M polymorphisms with risk of SLE and associated APS among Egyptian sample. The study included 120 SLE patients (45 without APS and 75 with APS) and 120 healthy subjects. PON1 Q192R and L55M polymorphisms were genotyped by real-time PCR. No significant differences in Q192R genotypes or allele frequencies were found between patients and controls (p = 0...
February 9, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28185015/association-between-the-hypertriglyceridemic-waist-phenotype-and-hyperuricemia-a-cross-sectional-study
#13
Shuang Chen, Xiaofan Guo, Siyuan Dong, Shasha Yu, Yintao Chen, Naijin Zhang, Yingxian Sun
The present study aimed to evaluate the relationship between the hypertriglyceridemic waist (HTGW) phenotype and hyperuricemia. We undertook a cross-sectional study with a sample of 11,576 adults from China. The HTGW phenotype was defined as elevated waist circumference (WC) and elevated triglyceride (TG) concentration. Logistic regression analysis was used to evaluate the association between the HTGW phenotype and hyperuricemia. The prevalence of hyperuricemia was significantly higher in individuals with the HTGW phenotype, as compared to those with the normal waist normal triglyceride (NWNT) group (25...
February 9, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28176037/fibromyalgia-in-patients-with-thyroid-autoimmunity-prevalence-and-relationship-with-disease-activity
#14
Sema Haliloglu, Bilge Ekinci, Hulya Uzkeser, Hakan Sevimli, Ayse Carlioglu, Pinar Mazlum Macit
Fibromyalgia (FM) is a syndrome characterised by chronic musculoskeletal pain, tenderness and other somatic symptoms. The prevalence of FM is approximately 2-7% in the general global population and is 30-40% in the population of Hashimoto thyroiditis (HT) with a structural pathology. In 2010, new classification criteria for FM were proposed, as an alternative to the American College of Rheumatology (ACR) 1990 criteria. The objectives of the present study were to identify the prevalence of FM in the HT population and evaluate the associated features by using the new diagnostic criteria...
February 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28176036/association-of-serum-uric-acid-and-risk-of-hypertension-in-adults-a-prospective-study-of-kailuan-corporation-cohort
#15
Liu-Fu Cui, Hui-Jing Shi, Shou-Ling Wu, Rong Shu, Na Liu, Guan-Ying Wang, Bin Zhou, Kai Sun, Ping Yu, Jian Wang, Hai-Cheng Song, Wen-Hao Yang, Jie-Rui Wang, Yi-Xuan Han, Rong Mu
Whether hyperuricemia is an independent risk factor for hypertension in adults is still under debate. To determine the association between serum uric acid and risk of hypertension in the Chinese population, we conducted a prospective study using the "Kailuan Corporation cohort." A total of 39,233 adult subjects with available data on serum uric acid were enrolled from 2006 to 2007. Subjects with established hypertension were excluded and were then grouped based on the gender and baseline quartile serum uric acid into F1-4 for women and M1-4 for men with F1 and M1 being the lowest quartiles...
February 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28168662/multicentric-castleman-s-disease-associated-with-iga-vasculitis-henoch-sch%C3%A3-nlein-purpura-responding-well-to-tocilizumab-a-case-report
#16
REVIEW
Yoichi Oshima, Junichi Hoshino, Tatsuya Suwabe, Noriko Hayami, Masayuki Yamanouchi, Akinari Sekine, Toshiharu Ueno, Hiroki Mizuno, Junko Yabuuchi, Aya Imafuku, Masahiro Kawada, Rikako Hiramatsu, Eiko Hasegawa, Naoki Sawa, Kenmei Takaichi, Nobukazu Hayashi, Takeshi Fujii, Yoshifumi Ubara
A 41-year-old man was referred to our hospital for the evaluation of hypergammaglobulinemia (IgG 2898 mg/dL and IgA 587 mg/dL), inflammation (CRP 6.7 mg/dL and serum interleukin-6 (IL-6) 15.1 ng/L), and anemia (Hb 10.9 mg/dL). Castleman's disease (CD) was diagnosed by axillary lymph node biopsy. Five months later, painful purpura (multiple palpable 5 mm lesions) developed on his legs, gradually spreading to the upper limbs, thighs, and trunk, accompanied by arthralgia of the wrists, ankles, and knees...
February 6, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28168661/psoriasis-in-systemic-lupus-erythematosus-a-single-center-experience
#17
Konstantinos Tselios, Kristy Su-Ying Yap, Rattapol Pakchotanon, Ari Polachek, Jiandong Su, Murray B Urowitz, Dafna D Gladman
The coexistence of psoriasis with systemic lupus erythematosus (SLE) has been reported in limited case series, raising hypotheses about shared pathogenetic mechanisms. Nevertheless, important differences regarding treatment do exist. The aim of the present study was to determine the prevalence and characteristics of psoriasis in a defined cohort of lupus patients. Patients with psoriasis were retrieved from the University of Toronto Lupus Clinic from its inception in 1970 up to 2015. Charts were hand-searched to collect information concerning demographic, clinical, and therapeutic variables...
February 6, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28168660/functional-limitation-and-associated-factors-in-outpatients-with-ankylosing-spondylitis-in-southwest-china
#18
Yuqing Song, Chen Wang, Hong Chen
Functional limitation is often complained by patients with ankylosing spondylitis (AS). With a rising number of patients suffering from AS, there are a limited number of reports focusing on functional limitation of AS in Chinese patients. This study was conducted to investigate the level of functional limitation and explore its associations with demographic, disease-related factors. A total of 303 AS outpatients were recruited in this cross-sectional study from a tertiary general hospital in Southwest China...
February 6, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28161769/radiographic-involvement-of-metacarpophalangeal-and-radiocarpal-joints-in-hand-osteoarthritis
#19
Olga Addimanda, Carlotta Cavallari, Elettra Pignotti, Lia Pulsatelli, Luana Mancarella, Roberta Ramonda, Antonella Fioravanti, Riccardo Meliconi
To evaluate, by means of a longitudinal study, radiographic involvement of metacarpophalangeal and radio-carpal joints in hand osteoarthritis, its relationship with erosive disease and its progression, 368 patients with hand osteoarthritis were enrolled. All patients underwent hand X-rays. On the basis of the presence of central erosions in interphalangeal joints, patients were divided into three groups: 0-no central erosions, 1-one joint with central erosion, and 2-two or more joints with central erosions...
February 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28161768/erap1-rs30187-single-nucleotide-polymorphism-does-not-confer-disease-susceptibility-in-north-indian-children-with-enthesitis-related-arthritis
#20
Rajni Srivastava, Sanat Phatak, Amita Aggarwal
ERAP1 single nucleotide polymorphisms (SNP) are associated with ankylosing spondylitis. Data on ERAP1SNPs in juvenile idiopathic arthritis (JIA) is scarce. ERAP1 rs30187 SNP was shown to confer risk in the enthesitis-related arthritis (ERA) category of JIA. We examined the prevalence and association of this SNP in Indian children with ERA. SNPs in ERAP1 (rs30187) were genotyped in children with ERA (n = 271), ankylosing spondylitis (AS) (n = 213) and healthy controls (n = 101), using Taqman genotyping...
February 4, 2017: Clinical Rheumatology
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