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Australasian Physical & Engineering Sciences in Medicine

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https://www.readbyqxmd.com/read/28342027/a-comparative-evaluation-of-ac225-vs-bi213-as-therapeutic-radioisotopes-for-targeted-alpha-therapy-for-cancer
#1
Barry J Allen
The Ac225:Bi213 generator is the mainstay for preclinical and clinical studies of targeted alpha therapy for cancer. Both Ac225 (four alpha decays) and Bi213 (one alpha decay) are being used to label targeting vectors to form the alpha immunoconjugate for cancer therapy. This paper considers the radiobiological and economic aspects of Ac225 vs Bi213 as the preferred radioisotope for preclinical and clinical TAT. The in vitro and in vivo evidence and the role of DNA repair processes is examined. The maximum tolerance dose and therapeutic gain are endpoints for comparison...
March 24, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28342026/high-dose-rate-brachytherapy-source-measurement-intercomparison
#2
Joel Poder, Ryan L Smith, Nikki Shelton, May Whitaker, Duncan Butler, Annette Haworth
This work presents a comparison of air kerma rate (AKR) measurements performed by multiple radiotherapy centres for a single HDR (192)Ir source. Two separate groups (consisting of 15 centres) performed AKR measurements at one of two host centres in Australia. Each group travelled to one of the host centres and measured the AKR of a single (192)Ir source using their own equipment and local protocols. Results were compared to the (192)Ir source calibration certificate provided by the manufacturer by means of a ratio of measured to certified AKR...
March 24, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28321636/the-effect-of-cement-on-hip-stem-fixation-a-biomechanical-study
#3
Talip Çelik, İbrahim Mutlu, Arif Özkan, Yasin Kişioğlu
This study presents the numerical analysis of stem fixation in hip surgery using with/without cement methods since the use of cement is still controversial based on the clinical studies in the literature. Many different factors such as stress shielding, aseptic loosening, material properties of the stem, surgeon experiences etc. play an important role in the failure of the stem fixations. The stem fixation methods, cemented and uncemented, were evaluated in terms of mechanical failure aspects using computerized finite element method...
March 20, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28321635/relative-biological-effectiveness-in-a-proton-spread-out-bragg-peak-formed-by-pencil-beam-scanning-mode
#4
Anna Michaelidesová, Jana Vachelová, Monika Puchalska, Kateřina Pachnerová Brabcová, Vladimír Vondráček, Lembit Sihver, Marie Davídková
In recent years, there is an increased interest in using scanning modes in proton therapy, due to the more conformal dose distributions, thanks to the spot-weighted dose delivery. The dose rate in each spot is however much higher than the dose rate when using passive irradiation modes, which could affect the cell response. The purpose of this work was to investigate how the relative biological effectiveness changes along the spread-out Bragg peak created by protons delivered by the pencil beam scanning mode...
March 20, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28290068/eeg-based-alpha-neurofeedback-training-for-mood-enhancement
#5
Swee Wu Phneah, Humaira Nisar
The aim of this paper is to develop a preliminary neurofeedback system to improve the mood of the subjects using audio signals by enhancing their alpha brainwaves. Assessment of the effect of music on the human subjects is performed using three methods; subjective assessment of mood with the help of a questionnaire, the effect on brain by analysing EEG signals, and the effect on body by physiological assessment. In this study, two experiments have been designed. The first experiment was to determine the short-term effect of music on soothing human subjects, whereas the second experiment was to determine its long-term effect...
March 13, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28290067/expert-system-classifier-for-adaptive-radiation-therapy-in-prostate-cancer
#6
Gabriele Guidi, Nicola Maffei, Claudio Vecchi, Giovanni Gottardi, Alberto Ciarmatori, Grazia Maria Mistretta, Ercole Mazzeo, Patrizia Giacobazzi, Frank Lohr, Tiziana Costi
A classifier-based expert system was developed to compare delivered and planned radiation therapy in prostate cancer patients. Its aim is to automatically identify patients that can benefit from an adaptive treatment strategy. The study predominantly addresses dosimetric uncertainties and critical issues caused by motion of hollow organs. 1200 MVCT images of 38 prostate adenocarcinoma cases were analyzed. An automatic daily re-contouring of structures (i.e. rectum, bladder and femoral heads), rigid/deformable registration and dose warping was carried out to simulate dose and volume variations during therapy...
March 13, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28258484/corpuls-cpr-resuscitation-device-generates-superior-emulated-flows-and-pressures-than-lucas-ii-in-a-mechanical-thorax-model
#7
S Eichhorn, A Mendoza Garcia, M Polski, J Spindler, A Stroh, M Heller, R Lange, M Krane
The provision of sufficient chest compression is among the most important factors influencing patient survival during cardiopulmonary resuscitation (CPR). One approach to optimize the quality of chest compressions is to use mechanical-resuscitation devices. The aim of this study was to compare a new device for chest compression (corpuls cpr) with an established device (LUCAS II). We used a mechanical thorax model consisting of a chest with variable stiffness and an integrated heart chamber which generated blood flow dependent on the compression depth and waveform...
March 3, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28255824/performance-of-epileptic-single-channel-scalp-eeg-classifications-using-single-wavelet-based-features
#8
Suparerk Janjarasjitt
Classification of epileptic scalp EEGs are certainly ones of the most crucial tasks in diagnosis of epilepsy. Rather than using multiple quantitative features, a single quantitative feature of single-channel scalp EEG is applied for classifying its corresponding state of the brain, i.e., during seizure activity or non-seizure period. The quantitative features proposed are wavelet-based features obtained from the logarithm of variance of detail and approximation coefficients of single-channel scalp EEG signals...
March 2, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28243923/risks-and-benefits-of-reducing-target-volume-margins-in-breast-tangent-radiotherapy
#9
Deepak Basaula, Alexandra Quinn, Amy Walker, Vikneswary Batumalai, Shivani Kumar, Geoff P Delaney, Lois Holloway
This study investigates the potential benefits of planning target volume (PTV) margin reduction for whole breast radiotherapy in relation to dose received by organs at risk (OARs), as well as reductions in radiation-induced secondary cancer risk. Such benefits were compared to the increased radiation-induced secondary cancer risk attributed from increased ionizing radiation imaging doses. Ten retrospective patients' computed tomography datasets were considered. Three computerized treatment plans with varied PTV margins (0, 5 and 10 mm) were created for each patient complying with the Radiation Therapy Oncology Group (RTOG) 1005 protocol requirements...
February 27, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28243922/quantification-of-intrafraction-prostate-motion-and-its-dosimetric-effect-on-vmat
#10
Prabhjot Juneja, Emma Colvill, Andrew Kneebone, Thomas Eade, Jin A Ng, David I Thwaites, Paul Keall, Ramandeep Kaur, Per Poulsen, Jeremy T Booth
Intrafraction prostate motion degrades the accuracy of radiation therapy (RT) delivery. Whilst a number of metrics in the literature have been used to quantify intrafraction prostate motion, it has not been established whether these metrics reflect the effect of motion on the RT dose delivered to the patients. In this study, prostate motion during volumetric modulated arc therapy (VMAT) treatment of 18 patients and a total of 294 fractions was quantified through novel metrics as well as those available in the literature...
February 27, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28236175/how-many-physicists-does-it-take-to-test-a-mammography-unit
#11
EDITORIAL
Jennifer Diffey
No abstract text is available yet for this article.
February 24, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28220403/dosimetry-in-mars-spectral-ct-topas-monte-carlo-simulations-and-ion-chamber-measurements
#12
Gray Lu, Steven Marsh, Jerome Damet, Pierre Carbonez, John Laban, Christopher Bateman, Anthony Butler, Phil Butler
Spectral computed tomography (CT) is an up and coming imaging modality which shows great promise in revealing unique diagnostic information. Because this imaging modality is based on X-ray CT, it is of utmost importance to study the radiation dose aspects of its use. This study reports on the implementation and evaluation of a Monte Carlo simulation tool using TOPAS for estimating dose in a pre-clinical spectral CT scanner known as the MARS scanner. Simulated estimates were compared with measurements from an ionization chamber...
February 20, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28220402/the-specific-absorption-rate-of-tissues-in-rats-exposed-to-electromagnetic-plane-waves-in-the-frequency-range-of-0-05-5%C3%A2-ghz-and-sarwb-in-free-moving-rats
#13
Bingxin Chen, Jiamin Wang, Hongxin Qi, Jie Zhang, Shude Chen, Xianghui Wang
As electromagnetic exposure experiments can only be performed on small animals, usually rats, research on the characteristics of specific absorption rate (SAR) distribution in the rat has received increasing interest. A series of calculations, which simulated the SAR in a male rat anatomical model exposed to electromagnetic plane waves ranging from 0.05 to 5 GHz with different incidence and polarization, were conducted. The whole-body-averaged SAR (SARwb) and the tissue-averaged SAR (SARavg) in 20 major tissues were determined...
February 20, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28220401/numerical-model-for-healthy-and-injured-ankle-ligaments
#14
Antonella Forestiero, Emanuele Luigi Carniel, Chiara Giulia Fontanella, Arturo Nicola Natali
The aim of this work is to provide a computational tool for the investigation of ankle mechanics under different loading conditions. The attention is focused on the biomechanical role of ankle ligaments that are fundamental for joints stability. A finite element model of the human foot is developed starting from Computed Tomography and Magnetic Resonance Imaging, using particular attention to the definition of ankle ligaments. A refined fiber-reinforced visco-hyperelastic constitutive model is assumed to characterize the mechanical response of ligaments...
February 20, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28220400/winning-images-from-the-photography-in-medical-physics-pimp-competition-radiation-signage-in-sight-%C3%A2-james-rijken-adelaide-radiotherapy-centre
#15
(no author information available yet)
No abstract text is available yet for this article.
February 20, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28210991/extraction-of-fetal-ecg-signal-by-an-improved-method-using-extended-kalman-smoother-framework-from-single-channel-abdominal-ecg-signal
#16
D Panigrahy, P K Sahu
This paper proposes a five-stage based methodology to extract the fetal electrocardiogram (FECG) from the single channel abdominal ECG using differential evolution (DE) algorithm, extended Kalman smoother (EKS) and adaptive neuro fuzzy inference system (ANFIS) framework. The heart rate of the fetus can easily be detected after estimation of the fetal ECG signal. The abdominal ECG signal contains fetal ECG signal, maternal ECG component, and noise. To estimate the fetal ECG signal from the abdominal ECG signal, removal of the noise and the maternal ECG component presented in it is necessary...
February 16, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28210990/indices-from-lagged-poincare-plots-of-heart-rate-variability-an-efficient-nonlinear-tool-for-emotion-discrimination
#17
Ateke Goshvarpour, Ataollah Abbasi, Atefeh Goshvarpour
Interest in human emotion recognition, regarding physiological signals, has recently risen. In this study, an efficient emotion recognition system, based on geometrical analysis of autonomic nervous system signals, is presented. The electrocardiogram recordings of 47 college students were obtained during rest condition and affective visual stimuli. Pictures with four emotional contents, including happiness, peacefulness, sadness, and fear were selected. Then, ten lags of Poincare plot were constructed for heart rate variability (HRV) segments...
February 16, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28197889/addendum-to-39-1-special-section-medical-imaging-and-insights-into-the-mechanics-of-heart-and-circulatory-physiology-and-dysfunction
#18
Martin Caon
No abstract text is available yet for this article.
February 14, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28194655/practical-time-considerations-for-optically-stimulated-luminescent-dosimetry-osld-in-total-body-irradiation
#19
Martin Butson, Mamoon Haque, Leon Smith, Ethan Butson, David Odgers, Dane Pope, Tina Gorjiana, May Whitaker, Johnny Morales, Angela Hong, Robin Hill
Total body irradiation (TBI) treatments are used to treat the whole body in preparation for hematopoietic stem cell (or bone marrow) transplantation. Our standard clinical regimen is a 12 Gy in 6 fraction, bi-daily technique using 6 MV X-rays at an extended Source-to-Surface distance (SSD) of 300 cm. Utilizing these characteristics, the beam dose rate is reduced below 7 cGy/min as is standard for TBI treatment. Dose received by the patient is monitored using optically stimulated luminescent dosimetry (OSLD)...
February 13, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28168587/improving-the-quality-of-reconstructed-x-ray-ct-images-of-polymer-gel-dosimeters-zero-scan-coupled-with-adaptive-mean-filtering
#20
M B Kakakhel, A Jirasek, H Johnston, T Kairn, J V Trapp
This study evaluated the feasibility of combining the 'zero-scan' (ZS) X-ray computed tomography (CT) based polymer gel dosimeter (PGD) readout with adaptive mean (AM) filtering for improving the signal to noise ratio (SNR), and to compare these results with available average scan (AS) X-ray CT readout techniques. NIPAM PGD were manufactured, irradiated with 6 MV photons, CT imaged and processed in Matlab. AM filter for two iterations, with 3 × 3 and 5 × 5 pixels (kernel size), was used in two scenarios (a) the CT images were subjected to AM filtering (pre-processing) and these were further employed to generate AS and ZS gel images, and (b) the AS and ZS images were first reconstructed from the CT images and then AM filtering was carried out (post-processing)...
February 6, 2017: Australasian Physical & Engineering Sciences in Medicine
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