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American Journal of Clinical Oncology

Kevin Wood, Elizabeth Byron, Linda Janisch, Ravi Salgia, Manish R Sharma
OBJECTIVES: For patients with unresectable or metastatic thymic epithelial neoplasms, few therapy options are available and outcomes are poor. This case series demonstrates that the combination of capecitabine and celecoxib may be a promising therapeutic option for these patients. MATERIALS AND METHODS: The current report describes the outcomes of 5 patients with thymic neoplasms treated on a drug-drug interaction study of capecitabine and celecoxib in patients with advanced solid malignancies (NCT01705106) conducted at the University of Chicago, plus a sixth patient treated with the same regimen outside of the protocol...
June 26, 2017: American Journal of Clinical Oncology
William A Stokes, Tyler P Robin, Matthew W Jackson, Arya Amini, Tracey E Schefter, Carolyn C Lefkowits, Christine M Fisher
OBJECTIVE: The objective of this study is to characterize patterns of utilization of adjuvant chemotherapy (CT) and radiotherapy (RT) in the posthysterectomy management of uterine carcinosarcoma (UCS) in the United States. MATERIALS AND METHODS: We queried the National Cancer Database for women diagnosed with UCS between 2004 and 2012 and undergoing hysterectomy. Logistic regression was performed to identify sociodemographic, facility-specific, and treatment-related predictors of receiving multiagent chemotherapy, external beam radiotherapy (EBRT), or brachytherapy (BT)...
June 26, 2017: American Journal of Clinical Oncology
Stephanie A Howard, Michael H Rosenthal, Lei Qin, Shanna A Matalon, Brandon D Bernard, Clair J Beard, Christopher J Sweeney
INTRODUCTION: Upgrading computerized tomography (CT) scanners to iterative reconstruction techniques (IRT) decreases radiation dose. This reduction, combined with changes in surveillance protocols in clinical stage I testicular cancer (CS1TC) measurably decrease the lifetime attributable risk (LAR) of dying of radiation-associated cancer. MATERIALS AND METHODS: This IRB-approved study enrolled 24 CS1TC patients who had CT scans on the same Toshiba Aquilion 64 CT before and after IRT software installation...
June 26, 2017: American Journal of Clinical Oncology
Amy R Rao, Daniel A Jones, Charles M Mendenhall, Syed N Rizvi, Jessica Kirwan, Christopher G Morris, Andrew Johns, William J McAfee, William M Mendenhall
OBJECTIVES: The purpose of this study was to retrospectively review outcomes for patients treated with definitive radiotherapy for carcinoma of the supraglottic larynx at a community hospital and to compare our results with the literature. MATERIALS AND METHODS: Treatment records of 46 patients with localized carcinoma of the supraglottic larynx treated from January 1987 through January 2012 were reviewed. Overall, 18 (39%) presented with stage I or II disease, whereas 28 (61%) presented with stage III to IV...
June 26, 2017: American Journal of Clinical Oncology
Bismarck Odei, Jean-Claude Rwigema, Frederick R Eilber, Fritz C Eilber, Michael Selch, Arun Singh, Bartosz Chmielowski, Scott D Nelson, Pin-Chieh Wang, Michael Steinberg, Mitchell Kamrava
OBJECTIVES: Myxofibrosarcoma (MFS) is reported to have a higher risk of local recurrence (LR) following definitive surgical excision relative to other soft tissue sarcomas. We reviewed our clinical experience treating MFS to investigate predictors of LR. MATERIALS AND METHODS: We retrospectively reviewed treatment outcomes for MFS patients treated at our institution between 1999 and 2015. A total of 52 patients were identified. Median age was 65 years (range, 21 to 86 y)...
June 20, 2017: American Journal of Clinical Oncology
Jonas Paludo, Karen Fritchie, Candace L Haddox, Peter S Rose, Carola A S Arndt, Randolph S Marks, Evanthia Galanis, Scott H Okuno, Steven I Robinson
OBJECTIVES: Extraskeletal osteosarcoma (EO) is a malignant neoplasm that produces osteoid, bone, and chondroid material without direct attachment to bone or periosteum. Surgical resection is the mainstay of treatment; the role of chemotherapy is not well defined. Therefore, we evaluated the impact of chemotherapy in the survival of patients with EO. METHODS: All EO patients seen at Mayo Clinic between 1990 and 2014 were assessed. Forty-three patients were included after all archived pathology slides were reviewed to confirm the diagnosis of EO...
June 15, 2017: American Journal of Clinical Oncology
Tony Y Eng, Tiffany W Chen, Abhilasha J Patel, Jill N Vincent, Chul S Ha
BACKGROUND: Urethral cancer is a rare malignancy, representing <1% of all malignancies. Optimal management, due to its rarity, presents as a treatment dilemma for physicians. There is a lack of consensus regarding treatment as large randomized trials cannot be performed; thus, optimal management decisions rely on study of retrospective cases. This is a review of our institutional experience with urethral cancer treated with various treatment modalities. METHODS: A retrospective chart review was performed on 31 patients treated for primary cancer of the urethra from 1958 to 2008...
May 23, 2017: American Journal of Clinical Oncology
Narek Shaverdian, Amar U Kishan, Darlene Veruttipong, D Jeffrey Demanes, Patrick Kupelian, Susan McCloskey, Michael L Steinberg, Christopher R King
OBJECTIVE: To assess the impact of the primary source of information used by prostate cancer patients to select a radiation treatment on their overall treatment experience and on treatment regret. METHODS: Patients with low to favorable intermediate-risk prostate cancer treated with stereotactic body radiation therapy, intensity-modulated radiation therapy, or high-dose rate brachytherapy were surveyed. The questionnaire explored the decision-making experience, treatment experience, and treatment regret...
May 23, 2017: American Journal of Clinical Oncology
Arjun Gupta, Avash Das, Kaustav Majumder, Nivedita Arora, Helen G Mayo, Preet P Singh, Muhammad S Beg, Siddharth Singh
OBJECTIVE: Excess body weight is associated with increased risk of developing hepatocellular cancer (HCC), but its effect on HCC-related mortality remains unclear. We performed a systematic review and meta-analysis to assess the association between premorbid obesity and HCC-related mortality. MATERIALS AND METHODS: Through a systematic literature search-up to March 2016, we identified 9 observational studies (1,599,453 individuals, 5705 HCC-related deaths) reporting the association between premorbid body mass index (BMI), and HCC-related mortality...
May 23, 2017: American Journal of Clinical Oncology
Saranrat Wittayanukorn, Jingjing Qian, Salisa C Westrick, Nedret Billor, Brandon Johnson, Richard A Hansen
PURPOSE: Although clinical trials have provided some data on the benefit of angiotensin-converting enzyme inhibitors (ACEIs) or β-blockers (BBs) in patients with chemotherapy-induced cardiotoxicity, evidence of ACEIs/BBs on prevention of trastuzumab and/or anthracycline-induced cardiotoxicity outside trials is limited. MATERIALS AND METHODS: A cohort study of 142,990 women (66 y and above) newly diagnosed with breast cancer from 2001 to 2009 was conducted using the Surveillance, Epidemiology, and End Results-Medicare-linked database...
May 23, 2017: American Journal of Clinical Oncology
Samar Krhili, Jean-Pierre Muratet, Sophie Roche, Yoann Pointreau, Sena Yossi, Anne-Lise Septans, Fabrice Denis
OBJECTIVES: To investigate the use of metabolic parameters as early prognostic factors during concomitant chemoradiotherapy for locally advanced cervix carcinoma (LACC). MATERIALS AND METHODS: Between February 2008 and January 2012, 34 consecutive patients treated for LACC (International Federation of Gynecology and Obstetrics Staging System stage IB2-IVA) were included in a retrospective study. Treatment was standard of care: total dose of 45 Gy in 1.8 Gy per fraction with concurrent cisplatin followed by brachytherapy...
June 2017: American Journal of Clinical Oncology
In J Park, Y Nancy You, John M Skibber, Miguel A Rodriguez-Bigas, Prajnan Das, Cathy Eng, Scott Kopetz, Robert A Wolff, Christopher H Crane, Sunil Krishnan, Bruce Minsky, Chung-Yuan Hu, Sa Nguyen, George J Chang
OBJECTIVE: Obesity is a major health concern and risk factor for colorectal cancer that may also impact cancer treatment and outcomes. Rectal cancer response to chemoradiotherapy (CXRT) is associated with long-term survival and sphincter preservation. The purpose of this study was to evaluate the impact of obesity on treatment outcomes after neoadjuvant CXRT for rectal cancer. METHODS: A retrospective cohort study of patients diagnosed (1993 to 2010) with cT3-4 or cN+ (by endorectal ultrasound, computed tomography, or magnetic resonance imaging) rectal carcinoma and treated with CXRT and total mesorectal excision was performed...
June 2017: American Journal of Clinical Oncology
Susannah Ellsworth, Xiaobu Ye, Stuart A Grossman
PURPOSE: Patients with glioblastoma (GBM) frequently deteriorate clinically and radiographically after chemoradiation and may require repeat surgical intervention. We attempted to correlate pathologic findings with preoperative clinical characteristics and survival in patients undergoing reoperation for GBM. MATERIALS AND METHODS: Patients eligible for this retrospective analysis had pathologically confirmed GBM diagnosed between 2005 and 2010, received standard radiation and temozolomide, and underwent repeat resection within 18 months of diagnosis...
June 2017: American Journal of Clinical Oncology
Breanne E Terakedis, Jason P Hunt, Luke O Buchmann, Vilija N Avizonis, Christopher J Anker, Ying J Hitchcock
IMPORTANCE AND BACKGROUND: Facial nerve (FN) palsy and perineural invasion (PNI) are adverse features in carcinomas of the parotid gland. FN sacrifice at the time of surgery is associated with significant morbidity. The role of adjuvant radiotherapy in patients with high-risk features, including FN involvement, remains unclear. OBJECTIVE: Analyze the disease-free survival (DFS) and overall survival (OS) and the impact of tumor characteristics, including FN involvement, for patients treated with surgical resection for carcinoma of the parotid gland...
June 2017: American Journal of Clinical Oncology
Xiang-Gao Zhu, Jin-Luan Li, Xiao-Fan Li, Yong-Heng Li, Qian-Yu Ni, Lin Wang, Shan-Wen Zhang, Jin Gu, Yong Cai, Chi Lin
OBJECTIVES: To evaluate local control and survival in locally advanced rectal adenocarcinoma patients who underwent a preoperative 2-week course of radiotherapy (RT) and to identify prognostic factors influencing the survival rate. METHODS: We analyzed 377 consecutively treated patients with locally advanced (T3/T4 or node positive) rectal adenocarcinoma. All patients underwent a preoperative 2-week course of RT (30 Gy in 10 fractions) followed by curative surgery...
June 2017: American Journal of Clinical Oncology
Giorgio Bogani, Antonella Cromi, Maurizio Serati, Stefano Uccella, Violante Di Donato, Jvan Casarin, Edoardo Di Naro, Fabio Ghezzi
OBJECTIVE: To identify factors predicting for recurrence in vulvar cancer patients undergoing surgical treatment. METHODS: We retrospectively evaluated data of consecutive patients with squamous cell vulvar cancer treated between January 1, 1990 and December 31, 2013. Basic descriptive statistics and multivariable analysis were used to design predicting models influencing outcomes. Five-year disease-free survival (DFS) and overall survival (OS) were analyzed using the Cox model...
June 2017: American Journal of Clinical Oncology
Julianna Caon, Cheryl Alexander, Hosam A Kader
OBJECTIVES: Malignant myoepithelioma of salivary glands is a rare neoplasm; most arise in the parotid gland and minor salivary glands of the palate. Surgery has been the mainstay of treatment. METHODS: This is case report of a patient treated with primary radical radiotherapy and retrospective review of institutional experience. RESULTS: An 87-year-old man with locoregionally advanced malignant myoepithelioma of the parotid gland received radiotherapy alone with complete clinical response and sustained 39 months of posttreatment...
June 2017: American Journal of Clinical Oncology
Jerrold L Boxerman, Benjamin M Ellingson, Suriya Jeyapalan, Heinrich Elinzano, Robert J Harris, Jeffrey M Rogg, Whitney B Pope, Howard Safran
OBJECTIVE: For patients with high-grade glioma on clinical trials it is important to accurately assess time of disease progression. However, differentiation between pseudoprogression (PsP) and progressive disease (PD) is unreliable with standard magnetic resonance imaging (MRI) techniques. Dynamic susceptibility contrast perfusion MRI (DSC-MRI) can measure relative cerebral blood volume (rCBV) and may help distinguish PsP from PD. METHODS: A subset of patients with high-grade glioma on a phase II clinical trial with temozolomide, paclitaxel poliglumex, and concurrent radiation were assessed...
June 2017: American Journal of Clinical Oncology
Kimberly Perez, Howard Safran, William Sikov, Matthew Vrees, Adam Klipfel, Nishit Shah, Steven Schechter, Nicklas Oldenburg, Victor Pricolo, Kayla Rosati, Thomas Dipetrillo
PURPOSE: Following preoperative chemoradiation and surgery, many patients with stage II to III rectal cancer are unable to tolerate full-dose adjuvant chemotherapy. BrUOG R-224 was designed to assess the impact of COmplete Neoadjuvant Treatment for REctal cancer (CONTRE), primary chemotherapy followed by chemoradiation and surgery, on treatment delivery, toxicities, and pathologic response at surgery. METHODS: Patients with clinical stage II to III (T3 to T4 and/or N1 to N2) rectal cancer received 8 cycles of modified FOLFOX6 followed by capecitabine 825 mg/m bid concurrent with 50...
June 2017: American Journal of Clinical Oncology
Vikram Jairam, James B Yu, Sanjay Aneja, Lynn D Wilson, Shane Lloyd
OBJECTIVES: Given the limited resources available to conduct clinical trials, it is important to understand how trial sponsorship differs among different therapeutic modalities and cancer types and to consider the ramifications of these differences. METHODS: We searched for a cross-sectional register of active, phase III, randomized controlled trials (RCTs) studying treatment-related endpoints such as survival and recurrence for the 24 most prevalent malignancies...
June 2017: American Journal of Clinical Oncology
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