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American Journal of Clinical Oncology

Sarah B Fisher, Yi-Ju Chiang, Barry W Feig, Janice N Cormier, Kelly K Hunt, Keila E Torres, Christina L Roland
OBJECTIVES: Retroperitoneal sarcomas (RPS) are often large at diagnosis calling into question the seventh edition AJCC size classification of <5 cm (T1) or ≥5 cm (T2). The eighth edition expands T stage into 4 categories (T1: ≤5 cm, T2: 5<x≤10 cm, T3: 10<x≤15 cm, T4: >15 cm). We evaluated the prognostic ability of the eighth edition using the National Cancer Database (NCDB). METHODS: Patients with RPS treated between 1998 and 2011 were identified from the NCDB; overall survival (OS) was compared...
November 2, 2018: American Journal of Clinical Oncology
Eric Adjei Boakye, Kenton J Johnston, Thiago A Moulin, Paula M Buchanan, Leslie Hinyard, Betelihem B Tobo, Sean T Massa, Nosayaba Osazuwa-Peters
OBJECTIVES: The aim of the study was to estimate hospitalization cost, and factors associated with hospitalization costs and length of stay (LOS) of patients treated for head and neck cancer in the United States. METHODS: Data on 71,440 weighted hospital admissions from the 2014 National Inpatient Sample with a diagnosis of head and neck cancer were examined. Multivariable linear regression models estimated factors associated with hospitalization costs, and negative binomial regression models were used to identify factors associated with hospital LOS...
October 8, 2018: American Journal of Clinical Oncology
Frédéric Pamoukdjian, Evelyne Liuu, Philippe Caillet, Stéphane Herbaud, Mathilde Gisselbrecht, Johanne Poisson, Pascaline Boudou-Rouquette, Laurent Zelek, Elena Paillaud
Cancer is a disease of older people, but this age group has often been excluded from clinical trials of cancer, which leads to poor transportability of standardized treatments in older cancer patients. One of the main reasons for the exclusion is the heterogeneity of older people in several domains: social environment, comorbidities, dependency, functional status, nutritional status, cognition status, and mood status. Comprehensive geriatric assessment aims to assess this heterogeneity and has identified frequent health problems often unknown before therapeutic decisions, which allows for targeted geriatric interventions with or without follow-up and appropriate cancer treatment selection...
October 8, 2018: American Journal of Clinical Oncology
Siddharth Karanth, Suja S Rajan, Frances L Revere, Gulshan Sharma
OBJECTIVES: Racial disparities exist in end-of-life lung cancer care, which could potentially lead to considerable racial differences in end-of-life care costs. This study for the first time estimates the racial differences in end-of-life care costs among lung cancer patients, and identifies and quantifies factors that contribute the most to these differences using a statistical decomposition method. METHODS: This is a retrospective analysis of patients 66 years and older, diagnosed with stage I-IV lung cancer, who died on or before December 31, 2013, using the Surveillance Epidemiology and End Result-Medicare data from 1991 to 2013...
October 8, 2018: American Journal of Clinical Oncology
Mohamed A Elshaikh, Ankit Modh, Sharif Sakr, Resha Shrestha, Charlotte Burmeister, Rouba Ali-Fehmi, Rabbie K Hanna
OBJECTIVES: Available risk stratification methods for women with endometrial carcinoma are controversially defined. We sought to develop a simplified and an individualized prognostic index for cancer recurrence in women with International Federation of Gynecology and Obstetrics (FIGO) stage I endometrial carcinoma, solely of endometrioid histology. MATERIALS AND METHODS: We identified 976 women who underwent a hysterectomy and did not receive any adjuvant therapy...
September 26, 2018: American Journal of Clinical Oncology
Lillie O'steen, Robert J Amdur, Christopher G Morris, Kathryn E Hitchcock, William M Mendenhall
HYPOTHESIS: While treating patients with postoperative radiotherapy (RT) for squamous cell carcinoma of the oral tongue or floor of mouth, we hypothesized a low risk of tumor recurrence in the contralateral neck in the absence of contralateral neck RT when the primary tumor is >1 cm from the midline regardless of tumor thickness (TT) or depth of invasion (DOI)>4 mm. OBJECTIVE: The policy at our institution for many years has been to limit postoperative RT to the ipsilateral side when the primary tumor does not cross the midline, regardless of TT or DOI...
September 18, 2018: American Journal of Clinical Oncology
Vivek Verma, Waqar Haque, Dandan Zheng, Ferdinand Osayande, Chi Lin
OBJECTIVES: The CROSS trial established neoadjuvant chemoradiation followed by surgery (nCRT-S) as superior to surgery alone (S) for locally advanced esophageal cancer (EC). However, because patients above 75 years of age were excluded, this comparison cannot be extrapolated to older patients. This study of a large, contemporary national database evaluated practice patterns in elderly patients ineligible for CROSS, and analyzed overall survival (OS) between nCRT+S, S, and definitive CRT (dCRT)...
September 13, 2018: American Journal of Clinical Oncology
Amanda J W Gibson, Haocheng Li, Adrijana D'Silva, Roxana A Tudor, Anifat A Elegbede, Shannon Otsuka, Dafydd Gwyn Bebb, Winson Y Cheung
OBJECTIVES: To compare the clinical characteristics and outcomes between relapsed and de novo metastatic non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: We reviewed all NSCLC diagnoses between January 1999 and December 2013 in the institutional Glans-Look Lung Cancer Database, which contains demographic, clinical, pathologic, treatment, and outcome information. Patients with distant metastasis at diagnosis (American Joint Committee on Cancer [AJCC] eighth edition, stage IV), the "de novo" cohort, were compared with the "relapsed" cohort, consisting of patients diagnosed with early stage disease (stage I/II) undergoing curative intent treatment and subsequently experiencing metastatic relapse...
September 11, 2018: American Journal of Clinical Oncology
Maclean Cook, Kelsey Baker, Mary Redman, Kristina Lachance, Macklin H Nguyen, Upendra Parvathaneni, Shailender Bhatia, Paul Nghiem, Yolanda D Tseng
OBJECTIVES: Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer with higher incidence among whites, elderly, and immunosuppressed patients. Although immunosuppressed MCC patients are at higher risk of recurrence and MCC-related death, it is unknown whether immunosuppression type is associated with differential outcomes. MATERIALS AND METHODS: We retrospectively evaluated 89 nonmetastatic MCC patients with a diagnosis of chronic immunosuppression...
September 11, 2018: American Journal of Clinical Oncology
Michele Prisciandaro, Raffaele Ratta, Francesco Massari, Giuseppe Fornarini, Salvatore Caponnetto, Roberto Iacovelli, Ugo De Giorgi, Gaetano Facchini, Sarah Scagliarini, Roberto Sabbatini, Claudia Caserta, Giorgia Peverelli, Alessia Mennitto, Elena Verzoni, Giuseppe Procopio
OBJECTIVE: The activity of cabozantinib in nonclear cell histologies has not been evaluated. MATERIALS AND METHODS: Data were collected across 24 Italian hospitals. Patients were aged 18 years and older with advanced nonclear cell renal cell carcinoma (RCC), with an Eastern Cooperative Oncology Group Performance Status 0 to 2, who had relapsed after previous systemic treatments for metastatic disease. Cabozantinib was administered orally at 60 mg once a day in 28 days cycles...
September 10, 2018: American Journal of Clinical Oncology
Daniel J Wale, Benjamin L Viglianti, Milton D Gross, Alice Ferretti, Domenico Rubello, Ka Kit Wong
Painful osseous metastasis resulting from castration-resistant prostate carcinoma is a common clinical problem. Historically, nuclear medicine offered several palliative beta-emitting radiopharmaceuticals targeting the skeleton with the goal of decreasing pain. However, these have largely been replaced by the alpha-emitting agent radium (Ra). Ra received Food and Drug Administration approval in 2013 for the treatment of metastatic castration-resistant prostate cancer with symptomatic bone metastases without visceral metastases...
September 10, 2018: American Journal of Clinical Oncology
Vaagn Andikyan, Annie Kim, Herbert F Gretz, Konstantin Zakashansky, Monica Prasad-Hayes, Ann-Marie Beddoe, Peter Dottino, John Mandeli, Linus Chuang
OBJECTIVE: The objective of this study was to evaluate the safety and efficacy of laparoscopic assessment to determine the likelihood of achieving optimal cytoreduction (OC) in patients undergoing primary debulking surgery (PDS) for ovarian cancer. METHODS: All patients who underwent diagnostic laparoscopy and PDS at our institution from January 2008 to December 2013 were identified. We determined the likelihood of achieving optimal cytoreduction by laparoscopic assessment based on tumor site, pattern of spread, and disease burden...
October 2018: American Journal of Clinical Oncology
Amitoj Gill, Rohit Gosain, Shruti Bhandari, Rahul Gosain, Gurkirat Gill, Joseph Abraham, Kenneth Miller
BACKGROUND: Follow-up cancer care is important for patients who have received IV chemotherapy but some patients discontinue their care and are lost to follow-up (LFU) at the cancer center where they were treated. The purpose of this study was to determine what proportion of cancer survivors are LFU at 5 years after treatment, the timing of LFU, and the characteristics of those who do not continue survivorship care. METHODS: Adult patients with cancer who were treated with chemotherapy at a large community teaching hospital in 2006 and 2007 were identified and linked with State tumor registry data...
October 2018: American Journal of Clinical Oncology
Kevin Wood, Elizabeth Byron, Linda Janisch, Ravi Salgia, Manish R Sharma
OBJECTIVES: For patients with unresectable or metastatic thymic epithelial neoplasms, few therapy options are available and outcomes are poor. This case series demonstrates that the combination of capecitabine and celecoxib may be a promising therapeutic option for these patients. MATERIALS AND METHODS: The current report describes the outcomes of 5 patients with thymic neoplasms treated on a drug-drug interaction study of capecitabine and celecoxib in patients with advanced solid malignancies (NCT01705106) conducted at the University of Chicago, plus a sixth patient treated with the same regimen outside of the protocol...
October 2018: American Journal of Clinical Oncology
Eric P Xanthopoulos, Surbhi Grover, Priya M Puri, Michael N Corradetti, Samuel P Heilbroner, Nandita Mitra, Charles B Simone, Lilie L Lin
BACKGROUND: Adjuvant radiation therapy improves overall survival in patients with vulvar cancer with 2+ positive lymph nodes, but its benefit remains uncertain for 1 positive lymph node. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified node-positive, American Joint Committee on Cancer version 6-staged women with squamous cell vulvar carcinoma treated with and without radiation following surgery. The Kaplan-Meier approach assessed overall and cause-specific survival...
September 2018: American Journal of Clinical Oncology
Hiroko Machida, Aida Moeini, Marcia A Ciccone, Sayedamin Mostofizadeh, Tsuyoshi Takiuchi, Laurie L Brunette, Lynda D Roman, Koji Matsuo
OBJECTIVE: To examine survival outcomes of women with recurrent cervical cancer who received salvage chemotherapy with modified dose-dense paclitaxel (MDDP) monotherapy (paclitaxel 80 mg/m, administered on day 1, 8, and 15 without day 22). MATERIALS AND METHODS: A retrospective study was conducted to evaluate cause-specific survival after the first recurrence (SAR) of women with recurrent cervical cancer diagnosed between 2006 and 2014. Pooled analyses were performed to examine SAR in women who received MDDP monotherapy (n=17) for any treatment line, compared with those who received salvage chemotherapy with paclitaxel-doublet (n=18) and nonpaclitaxel regimens (n=52)...
September 2018: American Journal of Clinical Oncology
Ann F Callahan, Michael White, Philip Ituarte, Singh Gagandeep, Yanghee Woo, Yuman Fong, Laleh Melstrom
INTRODUCTION: Gastric carcinoid is a rare entity with complex management options. This study aims to determine if surgical intervention in patients with local, regional, and metastatic gastric carcinoid is associated with prolonged survival. MATERIALS AND METHODS: The California Cancer Registry merged with the California Office of Statewide Health Planning and Development was queried for patients with a diagnosis of gastric carcinoid (2000 to 2011). Clinicopathologic characteristics, management, and outcomes were evaluated...
September 2018: American Journal of Clinical Oncology
Francine E M Voncken, Rosa T van der Kaaij, Karolina Sikorska, Erik van Werkhoven, Jolanda M van Dieren, Cecile Grootscholten, Petur Snaebjornsson, Johanna W van Sandick, Berthe M P Aleman
OBJECTIVES: The objective of this study is to compare long-term outcomes between younger and older (70 y and above) esophageal cancer patients treated with curative intent. MATERIALS AND METHODS: Overall survival (OS), disease-free survival (DFS), and locoregional recurrence-free interval were compared between older (70 y and above) and younger (below 70 y) esophageal cancer patients treated between 1998 and 2013. Treatment consisted of neoadjuvant chemoradiotherapy with surgery or definitive chemoradiotherapy: 36 to 50...
September 2018: American Journal of Clinical Oncology
Amy R Rao, Daniel A Jones, Charles M Mendenhall, Syed N Rizvi, Jessica Kirwan, Christopher G Morris, Andrew Johns, William J McAfee, William M Mendenhall
OBJECTIVES: The purpose of this study was to retrospectively review outcomes for patients treated with definitive radiotherapy for carcinoma of the supraglottic larynx at a community hospital and to compare our results with the literature. MATERIALS AND METHODS: Treatment records of 46 patients with localized carcinoma of the supraglottic larynx treated from January 1987 through January 2012 were reviewed. Overall, 18 (39%) presented with stage I or II disease, whereas 28 (61%) presented with stage III to IV...
September 2018: American Journal of Clinical Oncology
Bismarck Odei, Jean-Claude Rwigema, Frederick R Eilber, Fritz C Eilber, Michael Selch, Arun Singh, Bartosz Chmielowski, Scott D Nelson, Pin-Chieh Wang, Michael Steinberg, Mitchell Kamrava
OBJECTIVES: Myxofibrosarcoma (MFS) is reported to have a higher risk of local recurrence (LR) following definitive surgical excision relative to other soft tissue sarcomas. We reviewed our clinical experience treating MFS to investigate predictors of LR. MATERIALS AND METHODS: We retrospectively reviewed treatment outcomes for MFS patients treated at our institution between 1999 and 2015. A total of 52 patients were identified. Median age was 65 years (range, 21 to 86 y)...
September 2018: American Journal of Clinical Oncology
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