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American Journal of Clinical Oncology

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https://www.readbyqxmd.com/read/29116951/induction-therapies-plus-surgery-versus-exclusive-radiochemotherapy-in-stage-iiia-n2-non-small-cell-lung-cancer-nsclc
#1
Branislav Jeremić
In spite of the growing body of data from prospective randomized clinical trials (PRCTs) and meta-analyses, the optimal treatment approach in patients with stage IIIA non-small cell lung cancer remains unknown. This review focuses on the available data directly confronting induction chemotherapy or induction radiochemotherapy (RT-CHT) when followed by surgery with exclusive RT-CHT. Seven PRCTs and 4 meta-analyses investigated this issue. In addition, numerous retrospective studies attempted to identify potential predictors and/or prognosticators that may have influenced the decision to offer surgery in a particular patient subgroup...
November 7, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29045266/travel-distance-as-a-barrier-to-receipt-of-adjuvant-radiation-therapy-after-radical-prostatectomy
#2
David D Yang, Vinayak Muralidhar, Brandon A Mahal, Clair J Beard, Kent W Mouw, Neil E Martin, Peter F Orio, Martin T King, Paul L Nguyen
OBJECTIVES: Following radical prostatectomy (RP), adjuvant radiation therapy (RT) decreases biochemical recurrence and potentially improves metastasis-free and overall survival for patients with high-risk pathologic features. Since adjuvant RT typically occurs daily over several weeks, the logistical challenges of extensive traveling may be a significant barrier to its use. We examined the association between distance to treatment facility and use of adjuvant RT. MATERIALS AND METHODS: We identified 97,568 patients in the National Cancer Database diagnosed from 2004 through 2011 with cT1-4N0-xM0-x prostate cancer and found to have high-risk pathologic features (pT3-4 stage and/or positive surgical margins) at RP...
October 17, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29045265/dose-escalation-study-of-concurrent-chemoradiotherapy-with-the-use-of-involved-field-conformal-radiotherapy-and-accelerated-hyperfractionation-in-combination-with-cisplatin-and-vinorelbine-chemotherapy-for-stage-iii-non-small-cell-lung-cancer-the-final-report
#3
Naruo Yoshimura, Takuhito Tada, Yoshiya Matsumoto, Kenji Sawa, Naoki Yoshimoto, Tomohiro Suzumura, Hidenori Tanaka, Shigeki Mitsuoka, Tatsuo Kimura, Tomohiro Tamiya, Tomonori Hirashima, Tomoya Kawaguchi, Shinzoh Kudoh, Masako Hosono, Kazuto Hirata
OBJECTIVES: A phase I study to determine a recommended dose of thoracic radiotherapy using accelerated hyperfractionation for unresectable non-small cell lung cancer was conducted. MATERIALS AND METHODS: We used chemotherapy of a cisplatin doublet and 2 dose levels of radiation with accelerated hyperfractionation. The radiation dose levels were: a total dose of 60 Gy in 40 fractions at level 1, and 66 Gy in 44 fractions at level 2. Eligible patients with unresectable stage III non-small cell lung cancer received cisplatin and vinorelbine...
October 17, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29045264/patterns-of-failure-in-patients-with-adult-medulloblastoma-presenting-without-extraneural-metastasis
#4
Meriem Mokhtech, Christopher G Morris, Daniel J Indelicato, Michael S Rutenberg, Robert J Amdur
OBJECTIVES: The objective of this study is to evaluate long-term outcomes, specifically patterns of tumor recurrence, in patients with adult medulloblastoma treated with radiotherapy. METHODS: We recorded outcomes of 28 (median age, 25 y) patients 18 years old or above with M0 to M3 medulloblastoma treated between 1971 and 2012. Among them, 61% had standard-risk disease. All received craniospinal irradiation with a posterior fossa boost. Median dose to the craniospinal axis was 36 Gy...
October 17, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29045263/diagnosis-of-axillary-web-syndrome-in-patients-after-breast-cancer-surgery-epidemiology-risk-factors-and-clinical-aspects-a-prospective-study
#5
Patricia V G Figueira, Cinira A S Haddad, Samantha K L de Almeida Rizzi, Gil Facina, Afonso C P Nazario
OBJECTIVES: Axillary web syndrome (AWS) is a complication after breast cancer surgery associated with the axillary approach. We defined a diagnosis tool as well as evaluated cord frequency, characteristics, and risk factors. METHODS: A prospective cohort study of 173 women followed-up at Breast Diseases Division of Universidade Federal de São Paulo between July 2014 and September 2015 was established as an evaluation protocol to diagnose AWS. Sociodemographic status, anthropometric values, range of motion, comorbidities, pain, cord frequency, and characteristics (localization, number, palpable, and/or visible) among other data were collected at different time points before and after surgery...
October 17, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29028642/-lost-to-follow-up-among-adult-cancer-survivors
#6
Amitoj Gill, Rohit Gosain, Shruti Bhandari, Rahul Gosain, Gurkirat Gill, Joseph Abraham, Kenneth Miller
BACKGROUND: Follow-up cancer care is important for patients who have received IV chemotherapy but some patients discontinue their care and are lost to follow-up (LFU) at the cancer center where they were treated. The purpose of this study was to determine what proportion of cancer survivors are LFU at 5 years after treatment, the timing of LFU, and the characteristics of those who do not continue survivorship care. METHODS: Adult patients with cancer who were treated with chemotherapy at a large community teaching hospital in 2006 and 2007 were identified and linked with State tumor registry data...
October 12, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28968257/clinical-characteristics-of-patients-experiencing-pathologic-complete-response-following-neoadjuvant-therapy-for-borderline-resectable-locally-advanced-pancreatic-adenocarcinoma
#7
Neda Hashemi-Sadraei, Olumide B Gbolahan, Hai Salfity, Bert O'Neil, Michael G House, Safi Shahda
OBJECTIVES: The purpose of this study is to describe clinical characteristics and outcomes of patients with borderline resectable pancreatic cancer (BRPC) or locally advanced pancreatic cancer (LAPC) who achieved pathologic complete response (pCR) following neoadjuvant therapy. MATERIALS AND METHODS: A single institution clinical database for patients with pancreatic ductal adenocarcinoma was queried. Between 2008 and 2014 patients were identified with BRPC and LAPC, who underwent surgical resection after receiving neoadjuvant treatment...
September 29, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28930776/a-phase1b-dose-escalation-study-of-recombinant-circularly-permuted-trail-in-patients-with-relapsed-or-refractory-multiple-myeloma
#8
Jian Hou, Lugui Qiu, Yaozhong Zhao, Xuejun Zhang, Yan Liu, Zhao Wang, Fang Zhou, Yun Leng, Shifang Yang, Hao Xi, Fuxu Wang, Bing Zhu, Wenming Chen, Peng Wei, Xiangjun Zheng
OBJECTIVES: Circularly permuted tumor necrosis factor-related apoptosis-inducing ligand (CPT), or CPT, is a novel antitumor drug candidate. This phase 1b study evaluated the safety, tolerability, pharmacokinetics (PK), and efficacy of single-agent CPT in patients with relapsed or refractory multiple myeloma (RRMM), and aimed to identify the recommended dose for the phase 2 study. MATERIALS AND METHODS: Patients received single or multiple doses (once daily for 5 consecutive days per 21-d cycle) of CPT intravenous infusion at doses of 5, 6...
September 19, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28930775/phase-i-ii-study-of-s-1-plus-cisplatin-alternating-with-s-1-plus-docetaxel-in-patients-with-advanced-gastric-cancer
#9
Ayumu Hosokawa, Takayuki Ando, Kohei Ogawa, Akira Ueda, Hiroki Yoshita, Hiroshi Mihara, Haruka Fujinami, Shinya Kajiura, Kazuhisa Yabushita, Naoki Horikawa, Yuka Kobayashi, Akira Yoshioka, Hideki Origasa, Toshiro Sugiyama
OBJECTIVES: To investigate the usefulness of S-1 plus cisplatin alternating with S-1 plus docetaxel as first-line treatment in patients with advanced gastric cancer, we conducted a phase I/II study to determine the maximum tolerated dose and recommended dose, and evaluate efficacy and toxicity. MATERIALS AND METHODS: Patients with histologically confirmed unresectable and recurrent gastric cancer were enrolled in this study. Cisplatin was administered on day 1 and the dose escalated by 10 mg/m from a starting dose of 40 mg/m in the phase I part...
September 19, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28906259/radiation-and-immunotherapy-in-high-grade-gliomas-where-do-we-stand
#10
Elizabeth Reznik, Andrew W Smith, Shoshana Taube, Justin Mann, Menachem Z Yondorf, Bhupesh Parashar, A Gabriella Wernicke
High-grade glioma is the most common primary brain tumor, with glioblastoma multiforme (GBM) accounting for 52% of all brain tumors. The current standard of care (SOC) of GBM involves surgery followed by adjuvant fractionated radiotherapy and chemotherapy. However, little progress has been made in extending overall survival, progression-free survival, and quality of life. Attempts to characterize and customize treatment of GBM have led to mitigating the deleterious effects of radiotherapy using hypofractionated radiotherapy, as well as various immunotherapies as a promising strategy for the incurable disease...
September 12, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26165418/definitive-chemoradiation-with-full-dose-gemcitabine-for-unresectable-pancreatic-cancer-efficacy-of-involved-field-radiotherapy
#11
Jessica Zhou, Charles X Fang, Jincheng Shen, Matthew J Schipper, Mark M Zalupski, Rebecca M Minter, Diane M Simeone, Deanna Hart, Taylor Eagle, Grace W Kimmel, Jeffrey Vainshtein, Theodore S Lawrence, Mary Feng
OBJECTIVES: Definitive chemoradiotherapy for unresectable pancreatic cancer has traditionally involved 5-fluorouracil-based chemotherapy. Our institution has a long history of combining gemcitabine and radiotherapy (RT), and performed a retrospective review of all patients treated in this manner. MATERIALS AND METHODS: We reviewed the records of 180 patients treated from 1999 to 2012. Mean RT dose was 40.9 Gy in 2.2-Gy fractions, and targeted only radiographically apparent disease...
October 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26083556/oncologic-outcome-of-ypt1-2n0-rectal-cancer-after-neoadjuvant-chemoradiotherapy-compared-with-pt1-2n0-rectal-cancer
#12
Seung Yeop Oh, Young Bae Kim, Kwang Wook Suh
OBJECTIVE: To investigate the oncologic outcome of ypT1-2N0 mid and lower rectal cancer after chemoradiotherapy (CRT) compared with pT1-2N0 rectal cancer. METHODS: We compared the oncologic outcome of patients with mid and lower rectal cancer who underwent preoperative CRT and who did not, between February 2005 and August 2012. RESULTS: Compared with patients who did not receive preoperative CRT, patients who received preoperative CRT did not have significantly different clinicopathologic features except clinical stage and distal resection margin...
October 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26017484/ipilimumab-and-stereotactic-radiosurgery-versus-stereotactic-radiosurgery-alone-for-newly-diagnosed-melanoma-brain-metastases
#13
Kirtesh R Patel, Sana Shoukat, Daniel E Oliver, Mudit Chowdhary, Monica Rizzo, David H Lawson, Faisal Khosa, Yuan Liu, Mohammad K Khan
BACKGROUND: We compared the safety and efficacy of ipilimumab and stereotactic radiosurgery (SRS) to SRS alone for newly diagnosed melanoma brain metastases (MBM). MATERIALS AND METHODS: We reviewed records of newly diagnosed MBM patients treated with SRS from 2009 to 2013. The primary endpoint of overall survival (OS), and secondary endpoints of local control, distant intracranial failure, and radiation necrosis were compared using Kaplan-Meier method. Univariate and multivariate analysis were performed using the Cox proportional hazards method...
October 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26017483/dose-volume-predictors-of-esophagitis-after-thoracic-stereotactic-body-radiation-therapy
#14
Eileen M Harder, Zhe Jay Chen, Henry S Park, Brandon R Mancini, Roy H Decker
OBJECTIVES: Esophageal toxicity has become a major concern as stereotactic hypofractionated radiation therapy is increasingly utilized for central pulmonary tumors. Our purpose was to define esophageal dosimetric parameters that predict potentially dose-limiting toxicities. MATERIALS AND METHODS: In total, 157 patients with a planning target volume ≤5 cm from the esophagus were selected from an institutional database. Toxicity was scored with the CTCAE v4.0. Esophageal Dmax and Dv (dose D in Gy covering volume v in mL) in 0...
October 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26017482/locoregional-and-overall-recurrence-after-neaodjuvant-endocrine-therapy-versus-chemotherapy-in-postmenopausal-women-with-estrogen-receptor-her2-breast-cancer
#15
Jean L Wright, Kunal Saigal, Isildinha M Reis, Wei Zhao, Cristiane Takita, Tadeu Ambros, Ali M Saeed, Victoria Sujoy, Judith Hurley
PURPOSE: We report clinical outcomes in patients treated with neoadjuvant endocrine therapy (NET) versus neoadjuvant cytotoxic chemotherapy (NCT) in a cohort of postmenopausal women with ER+, HER2- breast cancer. MATERIALS AND METHODS: We retrospectively reviewed 140 patients treated between May 1998 and September 2010 and collected patient, disease, and treatment characteristics, response to neoadjuvant therapy, and clinical outcome. RESULTS: The median age was 59...
October 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26017481/a-model-to-predict-the-feasibility-of-concurrent-chemoradiotherapy-with-temozolomide-in-glioblastoma-multiforme-patients-over-age-65
#16
Florian Putz, Stefan Knippen, Godehard Lahmer, Rainer Fietkau, Sabine Semrau
OBJECTIVES: It is controversial whether concurrent chemoradiotherapy (CRT) with temozolomide is feasible and beneficial in elderly patients with glioblastoma. MATERIALS AND METHODS: Retrospective analysis of 74 elderly glioblastoma patients (65 y and above) treated with concurrent CRT with temozolomide. Factors influencing prognosis and feasibility of CRT were investigated. RESULTS: The median overall survival was 11.3 months. Univariate analysis showed a significant difference in median overall survival for cumulative dose of concurrent temozolomide (optimal cutoff, 2655 mg/m; 13...
October 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/25844825/seven-year-outcomes-following-accelerated-partial-breast-irradiation-stratified-by-astro-consensus-groupings
#17
Maha S Jawad, Chirag Shah, J Ben Wilkinson, Michelle Wallace, Christina K Mitchell, Jessica Wobb, Gregory S Gustafson, Donald S Brabbins, Inga S Grills, Peter Y Chen
OBJECTIVES: Limited long-term data exist regarding outcomes for patients treated with accelerated partial breast irradiation (APBI), particularly, when stratified by American Society for Radiation Oncology (ASTRO) Consensus Statement (CS) risk groups. The purpose of this analysis is to present 5- and 7-year outcomes following APBI based on CS groupings. MATERIALS AND METHODS: A total of 690 patients with early-stage breast cancer underwent APBI from 1993 to 2012, receiving interstitial brachytherapy (n=195), balloon-based brachytherapy (n=290), or 3-dimensional conformal radiotherapy (n=205) at a single institution...
October 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/25844824/factors-associated-with-guideline-recommended-kras-testing-in-colorectal-cancer-patients-a-population-based-study
#18
Mary E Charlton, Jordan J Karlitz, Jennifer A Schlichting, Vivien W Chen, Charles F Lynch
OBJECTIVES: Response to epidermal growth factor receptor inhibitors is poorer among stage IV colorectal cancer (CRC) patients with KRAS mutations; thus KRAS testing is recommended before treatment. KRAS testing was collected by Surveillance, Epidemiology, and End Results (SEER) registries for 2010 CRC cases, and our goal was to provide the first population-based estimates of testing in the United States. METHODS: SEER CRC cases diagnosed in 2010 were evaluated (n=30,351)...
October 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/25844823/eligibility-of-metastatic-pancreatic-cancer-patients-for-first-line-palliative-intent-nab-paclitaxel-plus-gemcitabine-versus-folfirinox
#19
MULTICENTER STUDY
Renata D Peixoto, Maria Ho, Daniel J Renouf, Howard J Lim, Sharlene Gill, Jenny Y Ruan, Winson Y Cheung
OBJECTIVES: The PRODIGE and MPACT trials showed superiority of FOLFIRINOX and nab-paclitaxel plus gemcitabine (NG) over gemcitabine alone, respectively. However, both had strict inclusion criteria. We sought to determine the characteristics of patients with metastatic pancreatic cancer (MPC) which inform the appropriateness of first-line chemotherapy FOLFIRINOX and NG in routine practice. MATERIALS AND METHODS: Patients with MPC who initiated palliative chemotherapy with gemcitabine from 2000 to 2011 at the British Columbia Cancer Agency were identified...
October 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/25844822/stage-iiic-endometrial-cancer-relapse-and-survival-outcomes-in-women-treated-with-pelvic-or-extended-field-para-aortic-nodal-radiation-therapy
#20
Caroline L Holloway, Cheryl Alexander, Caroline Walter, Christina Aquino-Parsons, Pauline T Truong
PURPOSE: The optimal radiation (RT) volume for node-positive endometrial cancer is controversial. This study evaluates clinical outcomes in patients with stage IIIC, N1 endometrial cancer who received RT to the pelvis (PV RT) or pelvis plus para-aortic nodes (PV-PAN RT). METHODS: Overall, there were 89 women with stage IIIC endometrial cancer. Of these, 57 women had N1-only disease, forming the study cohort. Clinicopathologic characteristics, recurrence rates, endometrial cancer-specific survival (ECSS), and overall survival (OS) were examined among patients treated with pelvic RT (n=23) compared with pelvic plus para-aortic RT (n=34)...
October 2017: American Journal of Clinical Oncology
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